Relevant bibliographies by topics / Sortitio

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Academic literature on the topic 'Sortitio'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 March 2023

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Journal articles on the topic "Sortitio"

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Biville, Frédérique. "Sors, sortiri, sortitio. Pratiques et lexique du tirage au sort dans le monde romain." Participations Hors Série, HS (2019): 139. http://dx.doi.org/10.3917/parti.hs01.0139.

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Olesti Vila, Oriol, and Marc Mayer. "La sortitio de Ilici. Del documento epigráfico al paisaje histórico." Dialogues d'histoire ancienne 27, no. 1 (2001): 109–30. http://dx.doi.org/10.3406/dha.2001.2439.

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Ioannidopoulos, Grégory. "M. Aemilius Scaurus et P. Plautius Hypsaeus: Pompée et ses questeurs entre 67 et 61." L'antiquité classique 86, no. 1 (2017): 97–113. http://dx.doi.org/10.3406/antiq.2017.3909.

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M. Aemilius Scaurus (pr. 56) et P. Plautius Hypsaeus (pr. 55) furent des proches de Pompée, auquel ils doivent une bonne partie de leur cursus, notamment une questure orientale qui ouvrit la voie à leurs carrières politiques, dont Pompée n’était jamais absent. En examinant en détail la vie de ces deux hommes et les pratiques de leur époque, plusieurs éléments ont été dégagés qui suggèrent de dater leurs questures non seulement de façon concomitante, mais surtout un peu plus tôt que généralement admis. Car elles pourraient bien être tombées en 67, en vertu de la lex Gabinia. Ainsi, Scaurus et Hypsaeus illustrent la façon dont Pompée concevait ses rapports avec ses questeurs, préférant la sélection extra sortem. En la matière, une rapide comparaison avec les pratiques de Sylla et César suggère une évolution majeure au Ier s. av. J.-C., marquée par le mépris des règles républicaines de la sortitio.
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Bouricius, Terrill. "Why Hybrid Bicameralism Is Not Right for Sortition." Politics & Society 46, no. 3 (August 13, 2018): 435–51. http://dx.doi.org/10.1177/0032329218789893.

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Structural problems are examined with pairing two chambers, one selected by election and the other by sortition, into a traditional bicameral system. It is argued that an all-purpose legislative chamber modeled on existing elected chambers is a mismatch for sortition and that purported benefits of maintaining partisan elections alongside sortition are illusory. Alleged benefits of a hybrid bicameral system are shown to be outweighed by a variety of harmful effects. Furthermore, even if those harms are not substantiated, the continued existence of an elected chamber will likely result in the delimitation of the sortition chamber. Combining many different sorts of minipublics with different characteristics and functions is preferable, and a possible multibody sortition legislative system is presented. Finally, an alternative way forward for sortition is proposed by peeling away individual topic areas from elected bodies and transferring them to sortition bodies.
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Gastil, John, and Erik Olin Wright. "Legislature by Lot: Envisioning Sortition within a Bicameral System." Politics & Society 46, no. 3 (August 13, 2018): 303–30. http://dx.doi.org/10.1177/0032329218789886.

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In this article, we review the intrinsic democratic flaws in electoral representation, lay out a set of principles that should guide the construction of a sortition chamber, and argue for the virtue of a bicameral system that combines sortition and elections. We show how sortition could prove inclusive, give citizens greater control of the political agenda, and make their participation more deliberative and influential. We consider various design challenges, such as the sampling method, legislative training, and deliberative procedures. We explain why pairing sortition with an elected chamber could enhance its virtues while dampening its potential vices. In our conclusion, we identify ideal settings for experimenting with sortition.
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Wright, Erik Olin. "Postscript to Gastil and Wright: The Anticapitalist Argument for Sortition." Politics & Society 46, no. 3 (August 13, 2018): 331–35. http://dx.doi.org/10.1177/0032329218789887.

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Sonnert, Gerhard. "Give Chance a Chance: An Alternative Process for Selecting U.S. Supreme Court Justices." Alternatives: Global, Local, Political 45, no. 1 (February 2020): 33–49. http://dx.doi.org/10.1177/0304375419901220.

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This article develops the proposal that U.S. Supreme Court Justices should be selected by sortition. The greatest threat to the legitimacy of the Supreme Court emanates from ever more politicized selection contests under the current system. Removing politics from Supreme Court recruitment is therefore crucial, and sortition is argued to be a suitable vehicle for accomplishing this. The proposal is motivated through a wider discussion of sortition and democracy.
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Owen, David, and Graham Smith. "Sortition, Rotation, and Mandate: Conditions for Political Equality and Deliberative Reasoning." Politics & Society 46, no. 3 (August 13, 2018): 419–34. http://dx.doi.org/10.1177/0032329218789892.

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The proposal to create a chamber selected by sortition would extend this democratic procedure into the legislative branch of government. However, there are good reasons to believe that, as currently conceived by John Gastil and Erik Olin Wright, the proposal will fail to realize sufficiently two fundamental democratic goods, namely, political equality and deliberative reasoning. It is argued through analysis of its historic and contemporary application that sortition must be combined with other institutional devices, in particular, rotation of membership and limited mandate, in order to be democratically effective and to realize political equality and deliberative reasoning. An alternative proposal for a responsive sortition legislature is presented as more realistic and utopian: one that increases substantially the number of members, makes more extensive use of internal sortition and rotation, and recognizes the importance of establishing limited mandates.
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Mulvad, Andreas Møller, and Benjamin Ask Popp-Madsen. "Sortition-infused democracy: Empowering citizens in the age of climate emergency." Thesis Eleven 167, no. 1 (November 15, 2021): 77–98. http://dx.doi.org/10.1177/07255136211056997.

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This article addresses two great global challenges of the 2020s. On one hand, the accelerating climate crisis and, on the other, the deepening crisis of representation within liberal democracies. As temperatures and water levels rise, rates of popular confidence in existing democratic institutions decline. So, what is to be done? This article discusses whether sortition – the ancient Greek practice of selecting individuals for political office through lottery – could serve to mitigate both crises simultaneously. Since the 2000s, sortition has attracted growing interest among activists and academics. Recently it has been identified in countries like the UK and France as a mechanism for producing legitimate political answers to the climate challenge. However, few theoretical reflections on the potentials and perils of sortition-based climate governance have yet emerged. This article contributes to filling the gap. Based on a critique of the first successful case of sortition used to enhance national environmental policy – in Ireland in 2017–18 – we argue that sortition-based deliberation could indeed speed up meaningful climate action whilst improving the health of democratic systems. However, this positive outcome is not preordained. Success depends not only on green social movements getting behind climate sortition but also on developing flexible, context-specific designs that identify adequate solutions to a number of problems, including those of power (providing citizens’ assemblies with clear agenda-setting prerogatives beyond non-binding consultation); expertise (allowing assembly participants to influence which stakeholders and experts to solicit inputs from); and participation (engaging wider parts of the citizenry in the deliberative process).
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Abbas, Nabila, and Yves Sintomer. "Three Contemporary Imaginaries of Sortition." Common Knowledge 28, no. 2 (May 1, 2022): 242–60. http://dx.doi.org/10.1215/0961754x-9809207.

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Abstract A contribution to the Common Knowledge symposium “Antipolitics,” this article examines the diverse types of imaginary that support sortition, which is currently at the heart of important debates on the reform of existing democratic institutions. Different and often diametrically opposed actors now advocate sortition as a tool for addressing crises of political representation. How are we to understand this convergence? Over the past two decades, the field of experience and the horizon of expectation of citizens in the global North have profoundly changed, and this article seeks to assess those changes in the context of three ideal types that advocate the use of randomly selected minipublics. This article analyzes, each in turn, the attraction of sortition for supporters and theorists of deliberative democracy, antipolitical democracy, and radical democracy, outlining the elements that unite and divide these imaginaries to help explain the astonishing convergence of voices in defense of sortition in politics.
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Dissertations / Theses on the topic "Sortitio"

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Dowlen, Oliver. "The political potential of sortition." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443717.

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Bothorel, Julie. "Le tirage au sort des provinces sous la République romaine et au début du Principat (227 av. J.-C. - 14 ap. J.-C.)." Electronic Thesis or Diss., Paris 10, 2019. http://www.theses.fr/2019PA100108.

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Dans la Rome républicaine et impériale, le hasard occupait une place importante tant dans la vie quotidienne que dans le fonctionnement des institutions. Le tirage au sort (sors ou sortitio en latin) était ainsi utilisé dans des contextes familiaux et privés (jeux de hasard ou pratiques magiques), dans les sanctuaires oraculaires, mais également dans la sphère civique afin de sélectionner des citoyens ou attribuer des tâches. Cette enquête étudie le tirage au sort utilisé pour répartir les provinces consulaires et prétoriennes entre les consuls et les préteurs en charge et, après 52 av. J.-C., sortis de charge (sortitio prouinciarum). Ce tirage au sort jouait un rôle stratégique dans la mesure où il permettait chaque année de répartir le commandement des armées et les principales tâches juridiques, judiciaires et administratives à Rome et dans l’Empire entre les magistrats curules tout en limitant les effets délétères de la compétition aristocratique. L’enquête débute à l’époque républicaine, plus précisément au IIIe siècle av. J.-C., siècle marqué par l’expansion territoriale de l’Empire et le développement des magistratures, et s’achève à la fin du règne d’Auguste, fondateur du Principat. Deux parties la structurent. La première restitue la législation qui encadrait alors le tirage au sort des provinces et étudie son évolution entre l’époque républicaine et impériale. La seconde analyse la manière dont était effectué, dans la pratique, le rituel du tirage au sort et les significations que lui donnaient les Romains
In Republican and Imperial Rome, chance played an important role, both in the private and the public sphere. While drawing of lots — called sors or sortitio in Latin — was commonly called upon for everyday purposes (in games of chance or magic rituals, for instance), and played an important role in oracular prophesies, the procedure was also used in an official context to assign public offices. We examine here a specific kind of sortition : the random drawing of provinces among consuls and praetors and, after 52 BCE, among former consuls and praetors. This sortition played a strategic role. It allowed indeed the Senate to assign military commands, juridical and judicial missions as well as administrative tasks in Rome and in the Empire among the high-ranking magistrates, while reducing the harmful effects of aristocratic competition. This research aims to restore the legal framework for the drawing by lot of provinces and to show how it evolved from the end of the 3rd century BCE until the reign of Augustus during the 1st century CE. It will then describe how the sortition worked out in practice and the meanings that Roman people attached to this ritual
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Säreborn, Alexander. "Sharpe vs. Sortino : En kamp om investerarna." Thesis, Karlstads universitet, Handelshögskolan, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-55297.

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Campbell, Charles. "Sortilin is a Negative Regulator of Sonic Hedgehog Processing and Anterograde Trafficking in Neurons." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34560.

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Sonic Hedgehog (SHH) is a secreted morphogen that is an essential regulator of patterning and growth. The SHH protein requires cleavage of its full-length precursor (SHHFL) for secretion of biologically active SHH (SHHNp). Mutations in SHH that affect SHH processing are associated with human disease, which highlights the importance of processing for patterning in vivo. We identified Sortilin (SORT1), a member of the VPS10P receptor family, as a novel SHH interacting protein. SORT1 preferentially associates with SHHFL and SORT1 levels correlate inversely with cleavage of SHHFL. Consistent with an antagonistic relationship between SORT1 and SHH processing, loss of SORT1 results in an increase in SHH levels in axons and a partial rescue of Hedgehog-associated patterning defects in a mouse model of deficient SHH processing. Finally, we demonstrate a functional requirement for SORT1-mediated trafficking on SHH-dependent signaling from axons in the developing visual system in vivo. Our findings identify a novel role for SORT1 in the regulation of SHH processing and trafficking.
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Sutherland, John Keith Bell. "Election by lot and the democratic diarchy." Thesis, University of Exeter, 2017. http://hdl.handle.net/10871/31813.

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This thesis argues that ‘democracy’ can better be understood in terms of a conceptual diarchy of ‘isonomia’ (equal political rights) and ‘isegoria’ (equal speech rights), rather than the conventional diarchy of ‘will’ and ‘opinion’ that originated in the era of absolute monarchy. As the proposed diarchy has its origin in classical Greece, the thesis starts with a brief overview of the institutional changes in sixth-, fifth- and fourth-century Athenian democracy that implemented the distinction in different ways, and examines some of its dysfunctions. The particular aspect of Athenian democracy under focus is sortition – the random selection of citizens for public office – viewed in antiquity as democratic, whereas election was viewed as an aristocratic or oligarchic selection mechanism. The thesis takes issue with Bernard Manin’s claim that the ‘triumph of election’ was on account of the natural right theory of consent, arguing that sortition-based proxy representation is a better way of indicating (hypothetical) consent than preference election. The thesis then seeks to clarify the concept(s) of representation – essential to the implementation of the democratic diarchy in modern large-scale societies – and to study how the diarchy has been reincarnated in modern representative democracies, along with an examination of the pathologies thereof. Consideration is given as to what the deliberative style of assemblies selected by lot should be, alongside evaluation of the epistemic potential of cognitive diversity and the ‘wisdom of crowds’. Given the need for both isonomia and isegoria to assume a representative form in large modern states, Michael Saward’s Representative Claim is adopted as a theoretical model to extend the reach of political representation beyond elections. The thesis concludes with tentative proposals as to how the fourth-century reforms (delegation of the final lawmaking decision to randomly-selected nomothetic courts) might be used as a template for modern institutions to resolve some of the problems of mass democracy.
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Asaro, Antonino [Verfasser]. "The effect of apolipoprotein E isoforms and sortilin in brain lipid homeostasis and Alzheimer’s disease / Antonino Asaro." Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1200409736/34.

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Yuan, Libin. "A stretch of 17 amino acids in the prosaposin C-terminus is critical for its binding to sortilin and targeting to lysosomes." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92262.

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Newly synthesized soluble lysosomal proteins are transported from the Golgi apparatus to the lysosomes by two mannose 6-phosphate receptors. However, the sphingolipid activator protein prosaposin is targeted by the alternative trafficking receptor, sortilin. Prosaposin is the precursor of four lysosomal saposins required for the hydrolysis of sphingolipids. A previous study demonstrated that the removal of its C-terminus abolished the trafficking of prosaposin to the lysosomes.
To identify the sequences and amino acids involved in the interaction of prosaposin to sortilin and its transport to the lysosomes, we generated six prosaposin deletion constructs and examined the effect of truncation by co-immunoprecipitation and confocal microscopy. The experiments revealed that a 17 amino acid stretch in the first half of the C-terminus (aa524-540) was necessary for the binding of prosaposin to sortilin and essential for its transport to the lysosomes.
Since the pH is able to induce conformational changes in the four saposin domains, we performed a pH-dependent binding assay to test whether or not the binding of prosaposin to sortilin was affected by different pHs. The experiments demonstrated that binding of prosaposin to sortilin occurred at 6.0 or higher. A substantial decrease in binding was detected at pH 5.5, and at pH 5.0 both proteins did not form complexes. This result indicated that the binding of prosaposin to sortilin is pH-dependent.
Since hydrophilic residues usually modulate pH-dependent protein interactions we introduced six site-directed point mutations in hydrophilic residues within the first half of the C-terminus. The results showed that the mutation of single hydrophilic amino acids did not affect the binding of prosaposin to sortilin.
Considering that tryptophan, cysteine and proline residues are important in protein structure and function, we also introduced eight site-directed point mutations to these residues within the 17 amino acid stretch in the C-terminus. The experiments revealed that two tryptophans (W530 and W535), and two cysteines (C528 and C536) were essential for the transport of prosaposin to the lysosomes. In addition, one proline residue (P532) was critical for the proper folding of prosaposin during its synthesis, which was demonstrated by the MG132 Proteasome Inhibition Assay.
In conclusion, we have narrowed down the sortilin recognition site on the prosaposin molecule to a specific 17-residue stretch in the first half of the C-terminus and discovered the essential residues in this region for the lysosomal trafficking of prosaposin.
Les protéines lysosomiales solubles récemment identifiées et synthétisées sont transférées de l'appareil de Golgi des cellules vers les lysosomes par deux récepteurs, des mannoses 6-phosphates. Cependant l'activateur sphingolipidique de la prosaposine est ciblé sur la lysosomes par un récepteur alternatif, la sortiline. La prosaposine est le précurseur de quatre saposines lysosomiales requises pour l'hydrolyse des sphingolipides. Une étude récente a déjà démontré que l'élimination de la terminaison-C de la sphingolipide empêche le transport de la prosaposine vers les lysosomes.
Pour identifier les séquences d'acides aminés impliqués dans l'interaction de la prosaposine avec la sortiline et ainsi clarifier le mode de transport de ces séquences vers les lysosomes, nous avons procédé, par co-immunoprécipitation et immunomicroscopie confocale et à l'élimination de six séquences distinctes de la saposine. Ces expériences ont montré que la première moitié de la terminaison-C (aa524-540) la séquence des 17 résidus peptidiques est nécessaire pour permettre la liaison de la sortiline à la prosaposine et le transport de la prosaposine vers les lysosomes. fr
Le pH du milieu agit sur l'interaction d'un ligand à son récepteur. Nous avons donc analysé la liaison de la prosaposine à la sortiline à différents pH. Les résultats on montré que la liaison de la prosaposine à la sortiline se fait à un pH de 6.0 ou plus. Par contre la prosaposine ne forme pas de complexes avec la sortiline à des pH de 5.0 et 5.5. fr
Puisque les résidus hydrophiles modulent normalement l'interaction des protéines nous avons introduit des mutations focales (point mutations) sur six sites de tels résidus hydrophiles de la terminaison-C de la prosaposine. Les résultats ont montré que de telles mutations n'ont aucun effet sur la liaison de la sortiline à la prosaposine. fr
Considérant que le tryptophane, la cystéine et la proline forment des séquences importantes de la structure et de la fonction des protéines, nous avons inséré huit mutations focales additionnelles sur la séquence de 17 résidus de la terminaison-C de la prosaposine. Les résultats ont révélé que deux molécules de tryptophane (W530 etW535) et deux molécules de cystéine (C528 et C536) sont essentielles au transport de la prosaposine vers les lysosomes. Par ailleurs, une molécule de proline (P532) provoque la dégradation de la prosaposine par des protéosomes. fr
En conclusion nous avons circonscrit certains aspects moléculaires de la relation de la sortiline à la prosaposine. Nous avons montré en particulier que la liaison de la sortiline à la prosaposine se situe au niveau d'un site précis du segment de la terminaison-C de la prosaposine dont certains éléments jouent un rôle essentiel dans le transport de la prosaposine vers les lysosomes. fr
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Al-Akhrass, Hussein. "Un rôle inédit de la sortiline dans le contrôle du transport rétrograde de l'EGFR pour limiter la croissance tumorale." Thesis, Limoges, 2017. http://www.theses.fr/2017LIMO0035/document.

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Le cancer du poumon est le troisième cancer le plus fréquent chez les femmes et le deuxième chez les hommes, il est la cause principale de décès par cancer dans le monde, avec une mortalité annuelle supérieure à 1 million. Malgré des progrès remarquables dans la thérapie ciblée, la majorité des patients atteints de cancer du poumon sont diagnostiqués dans un stade avancé où ils ne connaissent pas d'amélioration significative de leur survie globale. Les récepteurs à domaine tyrosine kinase, tels que le récepteur du facteur de croissance épidermique (EGFR), traduisent les informations du microenvironnement dans la cellule en activant des voies de signalisation homéostatiques. L'internalisation et la dégradation de l'EGFR suite à la liaison du ligand limitent l'intensité de la signalisation proliférative, ce qui contribue à maintenir l'intégrité cellulaire. Dans les cellules cancéreuses, la dérégulation du trafic de l’EGFR aboutit à des effets divers sur la progression tumorale. Dans cette étude, nous avons identifié la sortiline comme un régulateur clé de l'internalisation de l'EGFR à partir de la membrane plasmique. La perte de l’expression de la sortiline dans les cellules tumorales augmente la prolifération cellulaire en soutenant la signalisation de l’EGFR à la surface de la cellule, ce qui accélère la croissance tumorale. Chez les patients atteints de cancer du poumon, l'expression de la sortiline diminue avec l’augmentation du grade pathologique et l’expression de son gène, SORT1, est fortement corrélée à une meilleure survie globale, en particulier chez les patients présentant une forte expression de l'EGFR. Ainsi, la sortiline représente un nouveau régulateur du trafic intracellulaire de l’EGFR, elle agit en contrôlant l'internalisation de ce récepteur et en limitant la croissance tumorale
Lung cancer is the third most common cancer in women and the second in men, it is the leading cause of cancer-related death worldwide, with an annual mortality of more than 1 million. Despite remarkable advances in targeted therapy, the majority of patients with lung cancer are diagnosed at an advanced stage where they do not experience a significant improvement in overall survival. Tyrosine kinase receptors such as the epidermal growth factor receptor (EGFR) transduce information from the microenvironment into the cell and activate homeostatic signalling pathways. Internalisation and degradation of EGFR after ligand binding limits the intensity of its proliferative signalling, thereby helping to maintain cell integrity. In cancer cells, deregulation of EGFR trafficking has a variety of effects on tumour progression. Here, we report that sortilin is a key regulator of EGFR internalisation. Loss of sortilin in tumour cells promotes cell proliferation by sustaining EGFR signalling at the cell surface, ultimately accelerating tumour growth. In lung cancer patients, sortilin expression decreases with increased pathologic grade, and the expression of SORT1 (the gene encoding sortilin) is strongly correlated with a better survival, notably in patients with high EGFR expression. Thus, sortilin is a novel regulator of EGFR intracellular trafficking acting by controlling receptor internalisation and limiting tumour growth
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McCartney, Daniel Lawrence. "Investigating genome-wide transcriptional and methylomic consequences of a balanced t(1;11) translocation linked to major mental illness." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28873.

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Schizophrenia, bipolar disorder and major depressive disorder are devastating psychiatric conditions with a complex, overlapping genetic and environmental architecture. Previously, a family has been reported where a balanced chromosomal translocation between chromosomes 1 and 11 [t(1;11)] shows significant linkage to these disorders. This translocation transects three genes: Disrupted in schizophrenia- 1 (DISC1) on chromosome 1, a non-coding RNA, Disrupted in schizophrenia-2 (DISC2) antisense to DISC1, and a non-coding transcript, DISC1 fusion partner-1 (DISC1FP1) on chromosome 11, all of which could result in pathogenic properties in the context of the translocation. This thesis focuses on the genome-wide effects of the t(1;11) translocation, primarily examining differences in gene expression and DNA methylation, using various biological samples from the t(1;11) family. To assess the genome-wide effects of the t(1;11) translocation on methylation, DNA methylation was profiled in whole-blood from 41 family members using the Infinium HumanMethylation450 BeadChip. Significant differential methylation was observed within the translocation breakpoint regions on chromosomes 1 and 11. Downstream analysis identified additional regions of differential methylation outwith these chromosomes, while pathway analysis showed terms related to psychiatric disorders and neurodevelopment were enriched amongst differentially methylated genes, in addition to more general terms pertaining to cellular function. Using induced pluripotent stem cell (iPSC) technology, neuronal samples were developed from fibroblasts in a subset of individuals profiled for genome-wide methylation in whole blood (N = 6) with an aim to replicate the significant findings around the breakpoint regions. Here, methylation was profiled using the Infinium HumanMethylation450 BeadChip’s successor: the Infinium MethylationEPIC BeadChip. The results from the blood-based study failed to replicate in the neuronal samples, which could be attributed to low statistical power or tissue-specific factors such as methylation quantitative trait loci. The differences in methylation in the most significantly differentially methylated loci were found to be driven by a single individual, rendering further interpretation of the findings from this analysis difficult without additional samples. Cross-tissue analyses of DNA methylation were performed on blood and neuronal DNA from these six individuals, revealing little correlation between cell types. DISC1 is central to a network of interacting protein partners, including the transcription factor ATF4, and PDE4; both of which are associated with the cAMP signalling pathway. Haploinsufficiency of DISC1 due to the translocation may therefore be disruptive to cAMP-mediated gene expression. In order to identify transcriptomic effects which may be related to the t(1;11) translocation, genome-wide expression profiling was performed in lymphoblastoid cell line RNA from 13 family members. No transcripts were found to be differentially expressed at the genome-wide significant level. A post-hoc power analysis suggested that more samples would be required in order to detect genome-wide significant differential expression. However, imposing a fold-change cut-off to the data identified a number of candidate genes for follow-up analysis, including SORL1: a member of the brain-expressed Sortilin gene family. Sortilin genes have been linked to multiple psychiatric disorders including schizophrenia, bipolar disorder and Alzheimer’s disease. Follow-up analyses of Sortilin family members were performed in a Disc1 mouse model of schizophrenia, containing an amino acid substitution (L100P). Here, developmental gene expression profiling was performed with an additional aim to optimise and validate work performed by others using this mouse model. However, results from these experiments were variable between two independent batches mice tested. Additional investigation of Sortilin family genes was performed using GWAS data from human samples, using machine learning techniques to identify epistatic interactions linked to depression and brain function, revealing no statistically significant interactions. The results presented in this thesis suggest a potential mechanism for differential DNA methylation in the context of chromosomal translocations, and suggests mechanisms whereby increased risk of illness is conferred upon translocation carriers through dysregulation of transcription and DNA methylation.
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Moreno, Sébastien. "Le récepteur 3 de la neurotensine/Sortiline dans la régulation de l’état dépressif." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4136/document.

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Le trouble dépressif majeur est une pathologie qui atteint 20% de la population et qui représente le premier facteur de morbidité et d’incapacité au niveau mondial. Récemment, le canal potassique TREK-1 est une cible potentielle avérée dans le traitement de la dépression. La délétion de ce canal ou son blocage par un peptide dérivé résultant de la maturation de la sortiline, le propeptide (PE) ou son analogue synthétique la Spadine, résulte en un phénotype de résistance à la dépression. La sortiline est une protéine capable de s’associer à TREK-1 mais également au facteur neurotrophique BDNF important pour la viabilité neuronale et la régulation de l’état dépressif. La sortiline est donc impliquée dans la régulation de l’adressage intracellulaire de TREK-1 et du BDNF. Mes travaux se sont d’abords focalisés sur les conséquences de la délétion du gène codant pour la sortiline (Sort1-/-) sur l’adressage de TREK-1 et du BDNF, et également sur le système neurotensinergique. Les résultats révèlent au niveau cérébral une diminution de l’expression membranaire de TREK-1 et une augmentation de BDNF. L’ensemble de ces modifications conduisent les souris Sort1-/- à développer un phénotype de résistance à la dépression. De plus, ces souris présentent une augmentation de la concentration en neurotensine cérébrale ainsi que de son récepteur 2, ce qui entraine une résistance à la douleur. Par la suite, nous avons montré une diminution de la concentration sérique du PE chez les personnes dépressives, un niveau restauré après traitement avec des antidépresseurs. En conclusion, la sortiline joue un rôle prépondérant dans la régulation du trouble dépressif et aussi dans la nociception
Major depressive disorder is a condition that affects 20% of the population and is the leading cause of morbidity and disability worldwide. Recently, the TREK-1 potassium channel has been shown to be a potential target in the treatment of depression. The deletion of this channel or its blocking by a derived peptide resulting from the maturation of Sortilin, propeptide (PE), or its synthetic analogue Spadin, results in a phenotype of resistance to depression in mice. Sortilin is a protein able to bind with TREK-1 but also with the neurotrophic factor BDNF, an important factor for neuronal viability and depressive state regulation. Sortilin is therefore involved in regulating the intracellular addressing of TREK-1 and BDNF. Initially, my work focused on the consequences of the deletion of the Sortilin gene (sort1-/-) on the TREK-1 and BDNF addressing, and the neurotensinergic system. The results showed a decrease in TREK-1 membrane expression at the cerebral level and an increase in BDNF. All of these changes lead the Sort1-/- mice to develop a phenotype of resistance to depression. In addition, these mice show an increase in brain neurotensin concentration and its receptor 2, leading to increased resistance to pain perception. In a second phase, I was interested in whether PE, a potential antidepressant, showed serum variations in depressed patients and could be an indicator of depressive syndrome. We showed that the serum PE level is significantly reduced in depressed people, a level restored after treatment with antidepressants. In conclusion, Sortilin plays a major key in the regulation of depressive disorder and also in nociception
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Books on the topic "Sortitio"

1

Tudor, Octavian. Sortiți iubirii: Roman. București: Editura Eminescu, 1988.

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Airinei, Irina. Sortiți să vadă. București: Ideea Europeană, 2007.

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Bonifazi, Neuro. Allarmi e sortite. Locarno: A. Dadò, 1997.

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Sortino: Suoni, voci e memorie della tradizione. Palermo: Centro regionale per l'inventario, la catalogazione e la documentazione dei beni culturali e ambientali, 2008.

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Rossitto, Giuseppe. Sortino nei soprannomi: Storia, tradizioni, costumi, spigolature. Catania: C.U.E.C.M., 1989.

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Severino, Emanuele. Sortite: Piccoli scritti sui rimedi (e la gioia). Milano: Rizzoli, 1994.

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Borne, Alain. La marquise sortit à 5 heures: Nouvelles. Montélimar: Voix d'encre, 2000.

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Cabani, Maria Cristina. Gli amici amanti: Coppie eroiche e sortite notturne nell'epica italiana. Napoli: Liguori, 1995.

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Le jour où Mme Carmel sortit son revolver: Et autres nouvelles. Alger: Editions Dalimen, 2015.

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Ch'uch'ŏm minjujuŭi iron kwa silche: Chikchŏp, taeŭi minjujuŭi rŭl pohap hanŭn saeroun simin chŏngch'i p'aerŏdaim ŭi mosaek = Sortition democracy theory and practice. Kyŏnggi-do P'aju-si: Idam Books, 2012.

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Book chapters on the topic "Sortitio"

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Delgado, Jorge Costa, and José Luis Moreno Pestaña. "Democracy and sortition." In Routledge Handbook of Contemporary European Social Movements, 100–111. Abingdon, Oxon ; New York, NY : Routledge, 2020. | Series: Routledge international handbooks: Routledge, 2019. http://dx.doi.org/10.4324/9781351025188-8.

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Collmer, Constantine. "Civic Market and Sortition Democracy." In Essays in Contemporary Economics, 191–97. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-10043-2_13.

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McGlew, James. "Equality and sortition in Plato’s Laws." In Thinking the Greeks, 159–69. Abingdon, Oxon : Routledge, 2018. | Series: Routledge monographs in classical studies: Routledge, 2018. http://dx.doi.org/10.4324/9781315616711-12.

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Drew, Joseph. "Sortition: A Partial Defence of Human Dignity." In Natural Law & Government, 53–69. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2433-0_4.

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Chen, James Ming. "Sortino, Omega, Kappa: The Algebra of Financial Asymmetry." In Postmodern Portfolio Theory, 79–105. New York: Palgrave Macmillan US, 2016. http://dx.doi.org/10.1057/978-1-137-54464-3_6.

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Zhou, Xiaolai, Peter M. Sullivan, Daniel H. Paushter, and Fenghua Hu. "The Interaction Between Progranulin with Sortilin and the Lysosome." In Methods in Molecular Biology, 269–88. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8559-3_18.

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Bruzzone, Victor. "The Social Empowerment of Equal Chances: Sortition as a Democratic Bridge Between Liberalism and Socialism." In Liberalism and Socialism, 153–77. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-79537-5_6.

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Booth, G. Geoffrey, and John Paul Broussard. "The Sortino Ratio and Extreme Value Theory: An Application to Asset Allocation." In Extreme Events in Finance, 443–64. Hoboken, New Jersey: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781118650318.ch17.

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"Sortition and Politics." In Brill's Companion to the Reception of Athenian Democracy, 490–521. BRILL, 2020. http://dx.doi.org/10.1163/9789004443006_017.

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Stone, Peter. "The Idea of Sortition." In The Luck of the Draw, 119–44. Oxford University Press, 2011. http://dx.doi.org/10.1093/acprof:oso/9780199756100.003.0006.

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Conference papers on the topic "Sortitio"

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Alouf-Heffetz, Shiri, Ben Armstrong, Kate Larson, and Nimrod Talmon. "How Should We Vote? A Comparison of Voting Systems within Social Networks." In Thirty-First International Joint Conference on Artificial Intelligence {IJCAI-22}. California: International Joint Conferences on Artificial Intelligence Organization, 2022. http://dx.doi.org/10.24963/ijcai.2022/5.

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Voting is a crucial methodology for eliciting and combining agents' preferences and information across many applications. Just as there are numerous voting rules exhibiting different properties, we also see many different voting systems. In this paper we investigate how different voting systems perform as a function of the characteristics of the underlying voting population and social network. In particular, we compare direct democracy, liquid democracy, and sortition in a ground truth voting context. Through simulations -- using both real and artificially generated social networks -- we illustrate how voter competency distributions and levels of direct participation affect group accuracy differently in each voting mechanism. Our results can be used to guide the selection of a suitable voting system based on the characteristics of a particular voting setting.
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Akhrass, Hussein Al, Thomas Naves, Marie-Odile Jauberteau, François Vincent, and Fabrice Lalloué. "Abstract 3327: Sortilin controls the EGFR nuclear translocation." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3327.

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Marsolais, Christian, Cyndia Charfi, Michel Demeule, Jean-Christophe Currie, Alain Larocque, Alain Zgheib, Natacha Duquette, Richard Béliveau, and Borhane Annabi. "Abstract 2910: A novel Sortilin-targeted docetaxel peptide conjugate (TH1902), for the treatment of Sortilin-positive (SORT1+) triple-negative breast cancer." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-2910.

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Berger, K., S. Rhost, E. Hughes, H. Harrison, S. Rafnsdottir, H. Jacobsson, P. Gregersson, et al. "Abstract P2-06-11: Sortilin targeted therapy in breast cancer with elevated progranulin expression." In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p2-06-11.

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Akhrass, Hussein Al, James Conway, Mark Barok, Olav Andersen, and Johanna Ivaska. "Abstract P3-05-08: Sortilin-related receptor regulates receptor tyrosine kinase traffic and signaling." In Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-p3-05-08.

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Mohan, Vivek, Jai Govind Singh, and Weerakorn Ongsakul. "Sortino ratio based portfolio optimization considering EVs and renewable energy in microgrid power market." In 2017 IEEE Power & Energy Society General Meeting (PESGM). IEEE, 2017. http://dx.doi.org/10.1109/pesgm.2017.8274115.

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Annabi, Borhane, Michel Demeule, Jean-Christophe Currie, Alain Larocque, Alain Zgheib, Christian Marsolais, and Richard Béliveau. "Abstract 6362: TH1901, a novel curcumin-peptide conjugate for the treatment of Sortilin-positive (SORT1+) cancer." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-6362.

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Tanimoto, Ryuta, Chiara Palladino, Simone Buraschi, Shi-Qiong Xu, Leonard G. Gomella, Renato V. Iozzo, Antonino Belfiore, and Andrea Morrione. "Abstract 1344: Progranulin promotes ubiquitination, sorting and lysosomal degradation of sortilin in castration-resistant prostate cancer cells." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-1344.

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Marsolais, Christian, Jean-Christophe Currie, Michel Demeule, Cyndia Charfi, Alain Larocque, Alain Zgheib, Richard Béliveau, and Borhane Annabi. "Abstract 1313: TH1902, a docetaxel peptide-drug conjugate, shows pre-clinical efficacy in several Sortilin-positive (SORT1+) cancers." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1313.

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de Castro, Marcelo Augusto Farias, and Pedro Otoch. "Análise do Impacto da Crise Econômica no Mercado Imobiliário de Fortaleza Utilizando os Índices de Sharpe e Sortino." In 18ª Conferência Internacional da LARES. Latin American Real Estate Society, 2018. http://dx.doi.org/10.15396/lares_2018_paper_32-otoch-castro.

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