Academic literature on the topic 'Source code summarizing'

Decommissioning of the Ignalina Nuclear Power Plant involves multiple problems. One of them is personnel radiation safety during the performance of dismantling activities. In this paper, modeling results of radiation doses during the dismantling of the pressurized tank from the emergency core cooling system (ECCS PT) of RBMK-1500 reactor are presented. The radiological surveys indicate that the inner surface of the ECCS PT is contaminated with radioactive products of corrosion and sediments due to the radioactive water. The effective doses to the workers have been modeled for different strategies of ECCS PT dismantling. In order to select the optimal personnel radiation safety, the modeling has been performed by the means of computer code “VISIPLAN 3D ALARA Planning tool” developed by SCK CEN (Belgium). The impacts of dismantling tools, shielding types, and extract ventilation flow rate on effective doses during the dismantling of ECCS PT have been analyzed. The total effective personnel doses have been obtained by summarizing the effective personnel doses from various sources of exposure, that is, direct radiation from radioactive equipment, internal radiation due to inhalation of radioactive aerosols, and direct radiation from radioactive aerosols arising during hot cutting in premises. The uncertainty of the collective doses is also presented in this paper.

Introduction. In the current context of the spread of the coronavirus pandemic, the role of pharmacotherapy in the maintenance of immunopathological syndromes among patients with systemic diseases and patients with dual health disorders is growing. The need to adjust the pharmacotherapy regimens of systemic autoimmune diseases arises when addressing issues of quality, economic and physical availability of drugs in accordance with wholesale and retail prices. In continuation of the research, the aim of the work was to study and implement innovative approaches in the pharmacotherapy of systemic autoimmune diseases by content analysis on the example of antiviral drugs for international nonproprietary name (INN) Acyclovir. Materials and methods. The information base of the study consisted of scientific works of foreign and domestic scientists on the topic of the article. The review of scientific sources of literature was carried out taking into account the recommendations of the Cochrane Society for PICO. The names of drugs were systematized by INN, trade names, the number of drugs, dosage forms. For the content analysis, the method of drug selection developed by the Department of Medical and Pharmaceutical Law, General and Clinical Pharmacy of the Kharkiv Medical Academy of Postgraduate Education was used, which included seven criteria. Discussion. At the first stage of the study, a marketing analysis of the range of drugs for INN Acyclovir was performed. Medicines were selected, which according to the State Register of Medicines of Ukraine as of November 2020 were registered and allowed for circulation in health care facilities. After summarizing the processed data, a marketing list of drugs was compiled under the ATC code J05AB01 in accordance with the INN Acyclovir, which has 36 names of drugs. During the study, a discrete variation series of drug distribution was compiled, which indicates that the studied quantitative indicator of drug manufacturers fluctuates within the first group with the highest frequency (fi = 8). A graphic discrete variation in the form of a distribution polygon was created. Conclusions. Innovative approaches to the pharmacotherapy of systemic autoimmune diseases are the use of content analysis as an additional method in the study of pharmacotherapy of drugs. The study is based on the formalized method of qualitative and quantitative analysis of documents, which allows you to get a detailed picture of the selected clinical and pharmacological group of drugs – drugs by INN Aciclovir PBX code J05AB01. The analysis allows obtaining a complete description of the range and manufacturers of drugs approved for use.

istorical experience creates a particular system of codes and meanings in the culture of nations and societies. The memory of the past, with triumphs and defeats intertwined, is the basis of any form of collective identity. In some cases, the present and the past share a common historical guilt, in others, a great victory. It becomes a foundation for new moral imperatives, patriotic symbols, images of victims and heroes. For seventy years, the national historiography has been dominated by an apologetic concept of the Great October Revolution that had laid the foundation for the Soviet national identity. The historiographic canon, created in the thirties, underwent virtually no change. The gigantic historiography of the Great October has been developing within the traditional framework of the CPSU history espoused by several generations of historians. The unsuccessful February Revolution served as a simple background for the victorious October that brought down the tsarist regime and the dictatorship of the bourgeoisie. In the era of glasnost and archive revolution, there began a heated revision of the Soviet concept where emotions often won over scientific analysis. The changes of the last two decades made it possible to interpret the Revolution of 1917 as a multidimensional process of a drastic transformation of the entire Russian system, which, in its turn, changed the world order. Over the past few years, there has been a steep increase in the number of nonfictional historical publications containing archival materials, memoirs, and visual sources (posters, caricatures, etc.). The buildup of narrative material is so fastpaced that historians lag behind in interpreting and summarizing it. Factbased, fragmentary descriptions significantly prevail over the attempts to give it a conceptual interpretation, even though recent studies actively explore the mechanisms that trigger revolution, the nature of social protest and violence, the forms of legitimation of the new power, the cultural references of political radicalism, A particular attention is paid to the ethnocultural discourse of the revolutionary process. Despite a certain fragmentation of topics, The stages of political struggle gave way to one another as different forces attained power but found themselves unable to hold together this gigantic country that was falling apart. In this aspect, the dynamics of the revolutionary crisis in Russia was similar to the one of the French Revolution. It should be noted that the overall narrative of the revolutionary process and the vision of its development stages are defined not only by the center, but also by regions. The revolutionrelated research carried out by local historians is particularly impressive. Regional archives allow a recreation of a colorful, dramatic history of takeover/ interception/ transfer of power at the local level, full of clashes and conflicts. It is obvious though that the regional research requires further development and classification. At the same time, the level of scientific research does not allow to address the issue of the way in and out of the revolution. Many questions still remain unanswered after numerous conferences and publications in 2017. Which criteria are necessary to date the beginning and the end of the revolutionary process in Russia Can civil war be included in the overall revolutionary context, similar to the French Revolution The anatomy of any grandscale protest comprises of a sum of internal radical projects and strategies of external players with their own geopolitical interests. The Interests and Identities of all people, social and political groups, national and international elite that got involved in the process, voluntarily or involuntary, manifest themselves best of all in the cauldron of revolutionary ebullition. And for a researcher, the key motivation consists in distinguishing visible and seemingly invisible interactions of all these entities, comparing the external, eventrelated processes with the internal dynamics of power struggles. The topic of power and society analyzed against the background of the Revolution of 1917 includes the issues essential for understanding the quality of development of the Russian Empire in the early XXth century. In the papers by B. Mironov, V. Nikonov, N. Smirnov, the genesis of revolution is seen as a conflict of tradition and modernity. In 1905, Russia began its slow and painful progress from tsarist autocracy to parliamentary monarchy. this connection, modern historiography puts a particular emphasis on the analysis of civic engagement and the forms of selforganization of society. The Soviet vision of the tsarist regime as a suppressor of civil liberties, so actively used in modern Western papers, was revised. The Russian historiography is currently undergoing intense debates and methodological realignment, searching for new paradigms in the analysis of the revolutionary process. But most importantly, the historical continuity between the imperial, Soviet and postSoviet eras is being gradually restored in the papers covering the Revolution of 1917, and the idea of existence of a single revolutionary process from February to October 1917 is slowly taking shapeисторический опыт создает особую систему кодов и смыслов в культуре народов и обществ. Память о прошлом, где переплетаются триумфы и поражения, является основой любой формы коллективной идентичности. В одних случаях настоящее и прошлое объединяет общая историческая вина, в другихВеликая Победа. Она становится основой для новых нравственных императивов, патриотических символов, образов жертв и героев. На протяжении семидесяти лет в отечественной историографии доминировала апологетическая концепция Великой Октябрьской революции, заложившая основы советской национальной идентичности. Историографический канон, созданный в тридцатые годы, практически не претерпел изменений. Гигантская историография Великого Октября развивалась в традиционных рамках истории КПСС, поддерживаемой несколькими поколениями историков. Неудачная Февральская революция послужила простым фоном для победоносного октября, обрушившего царский режим и диктатуру буржуазии. В эпоху гласности и архивной революции начался бурный пересмотр советской концепции, где эмоции часто одерживали верх над научным анализом. Изменения последних двух десятилетий позволили интерпретировать революцию 1917 года как многомерный процесс кардинальной трансформации всей российской системы, которая, в свою очередь, изменила мировой порядок. За последние несколько лет резко возросло количество нехудожественных исторических изданий, содержащих архивные материалы, мемуары, визуальные источники (плакаты, карикатуры и др.). Накопление повествовательного материала происходит настолько быстро, что историки отстают в его интерпретации и обобщении. Фактологические, фрагментарные описания значительно превалируют над попытками дать ему концептуальную трактовку, хотя в последних исследованиях активно исследуются механизмы, запускающие революцию, характер социального протеста и насилия, формы легитимации новой власти, культурные отсылки политического радикализма, идеологические и социальные проблемы.В. Symbolic символическое перекодирование публичного пространства. Особое внимание уделено этнокультурному дискурсу революционного процесса. Несмотря на определенную фрагментарность тематики, российские историки разделяют идею непрерывности революционного процесса с февраля по октябрь 1917 года. Этапы политической борьбы сменялись друг другом по мере того, как различные силы приходили к власти, но оказывались неспособными удержать вместе эту гигантскую страну, которая разваливалась на части. В этом аспекте динамика революционного кризиса в России была схожа с динамикой Французской революции. Следует отметить, что общая нарративность революционного процесса и видение этапов его развития определяются не только центром, но и регионами. Особенно впечатляют исследования, связанные с революцией, проведенные местными историками. Региональные архивы позволяют воссоздать красочную, драматичную историю захвата / перехвата / передачи власти на местном уровне, полную столкновений и конфликтов. Однако очевидно, что региональные исследования требуют дальнейшего развития и классификации. В то же время уровень научных исследований не позволяет решить вопрос о входе и выходе революции. Многие вопросы до сих пор остаются без ответа после многочисленных конференций и публикаций в 2017 году. По каким критериям необходимо датировать начало и конец революционного процесса в России Может ли гражданская война быть включена в общий революционный контекст, подобный Французской революции Анатомия любого масштабного протеста складывается из суммы внутренних радикальных проектов и стратегий внешних игроков со своими геополитическими интересами. Интересы и идентичности всех людей, социальных и политических групп, национальной и международной элиты, которые вольно или невольно оказались вовлеченными в этот процесс, лучше всего проявляются в котле революционного кипения. А для исследователя ключевая мотивация состоит в различении видимых и, казалось бы, невидимых взаимодействий всех этих сущностей, сопоставлении внешних, событийных процессов с внутренней динамикой борьбы за власть. Тема власти и общества, анализируемая на фоне революции 1917 года, включает в себя вопросы, существенные для понимания качества развития Российской империи в начале ХХ века. В работах Б. Миронова, В. Никонова, Н.Смирнова Генезис революции рассматривается как конфликт традиции и современности. В 1905 году Россия начала свой медленный и болезненный путь от царского самодержавия к парламентской монархии. в этой связи современная историография уделяет особое внимание анализу гражданской активности и форм самоорганизации общества. Советское видение царского режима как подавителя гражданских свобод, столь активно используемое в современных западных газетах, было пересмотрено. Российская историография в настоящее время переживает интенсивные дискуссии и методологическую перестройку, поиск новых парадигм в анализе революционного процесса. Но самое главное, что историческая преемственность между имперской, советской и постсоветской эпохами постепенно восстанавливается в работах, освещающих революцию 1917 года, и постепенно оформляется идея существования единого революционного процесса с февраля по октябрь 1917 года

Abstract Summary Although the ability to programmatically summarize and visually inspect sequencing data is an integral part of genome analysis, currently available methods are not capable of handling large numbers of samples. In particular, making a visual comparison of transcriptional landscapes between two sets of thousands of RNA-seq samples is limited by available computational resources, which can be overwhelmed due to the sheer size of the data. In this work, we present TieBrush, a software package designed to process very large sequencing datasets (RNA, whole-genome, exome, etc.) into a form that enables quick visual and computational inspection. TieBrush can also be used as a method for aggregating data for downstream computational analysis, and is compatible with most software tools that take aligned reads as input. Availability and implementation TieBrush is provided as a C++ package under the MIT License. Precompiled binaries, source code and example data are available on GitHub (https://github.com/alevar/tiebrush). Supplementary information Supplementary data are available at Bioinformatics online.