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Journal articles on the topic 'SPEC kits'

Author: Grafiati

Published: 26 July 2024

Last updated: 31 July 2025

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1

Caiger, Anne. "SPEC Kits: Compiled Information about Library Management Policies, Procedures, and Techniques." American Archivist 53, no. 1 (1990): 158–61. http://dx.doi.org/10.17723/aarc.53.1.c32004r2676174l0.

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2

MYERS, MICHAEL J., HAILE F. YANCY, DOROTHY E. FARRELL, JEWELL D. WASHINGTON, and RUSSELL A. FROBISH. "Evaluation of Two Commercial Lateral-Flow Test Kits for Detection of Animal Proteins in Animal Feed." Journal of Food Protection 68, no. 12 (2005): 2656–64. http://dx.doi.org/10.4315/0362-028x-68.12.2656.

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Performance characteristics were evaluated for two lateral-flow test kits, Reveal for Ruminant in Feed (Neogen Corporation) and FeedChek (Strategic Diagnostics Inc.), designed to detect ruminant or terrestrial animal proteins in feeds. The stringent acceptance criteria used were developed by the Center for Veterinary Medicine Office of Research to identify test kits with comparable selectivity and sensitivity to microscopy and PCR assay, the analytical methods used by the U.S. Food and Drug Administration (FDA). Guidelines were developed for evaluating the selectivity, sensitivity, ruggedness,

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3

D'AOUST, J. Y., A. M. SEWELL, and P. GRECO. "Commercial Latex Agglutination Kits for the Detection of Food borne Salmonella." Journal of Food Protection 54, no. 9 (1991): 725–30. http://dx.doi.org/10.4315/0362-028x-54.9.725.

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The ability of the Bactigen® Salmonella Shigella (BSST), the Microscreen® (MS), and the Spectate® (SPECT) latex agglutination kits to detect Salmonella in pure cultures and in naturally contaminated foods was examined. Of 190 Salmonella strains tested, the MS, BSST, and SPECT systems correctly identified 89.5, 81.6, and 66.3% of the test cultures, respectively. The sensitivity of SPECT increased to 92.7% when only strains belonging to the targeted serogroups (somatic A to E plus G) and strains harboring the Vi antigen were considered. The lack of specificity of the MS (3.4%), SPECT (17.0%), an

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4

Calvert, Philip. "Use of Teams in ARL Libraries20004George J. Soete. Use of Teams in ARL Libraries. Washington, DC.: SPEC Kits No. 232, Association of Research Libraries, Office of Leadership and Management Services 1998. , ISBN: ISSN 01603582 Softback US$40.00 (US$25.00 ARL members)." Library Management 21, no. 5 (2000): 271–78. http://dx.doi.org/10.1108/lm.2000.21.5.271.4.

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5

Mahmood, Khalid. "Marketing and Public Relations Activities in ARL Libraries20004Evelyn O. Smykla. Marketing and Public Relations Activities in ARL Libraries. Washington DC: Association of Research Libraries, Office of Leadership and Management Services 1999. 109pp., ISBN: 0160 3582 US$40.00 SPEC Kits, 240." Library Review 49, no. 6 (2000): 303–10. http://dx.doi.org/10.1108/lr.2000.49.6.303.4.

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6

Moore, Penny. "The ARL Geographic Information Systems Literacy Project20011D. Kevin Davie. The ARL Geographic Information Systems Literacy Project. Washington, DC: SPEC Kits 1999. 37 pp. US$40.00 (US$25.00 ARL members) (softback) , ISBN: ISSN 01603582 Association of Research Libraries, Office of Leadership and Management Services." Library Hi Tech 19, no. 1 (2001): 88–89. http://dx.doi.org/10.1108/lht.2001.19.1.88.1.

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7

Lanier, Don. "The Gifts and Exchange Function in ARL Libraries20001Comp. by Catherine Denning. The Gifts and Exchange Function in ARL Libraries. Washington, DC, Association of Research Libraries, Office of Leadership and Management Services: SPEC Kits, 241 1999. 116 pp., ISBN: 01603582 US$40.00 (US$25.00 ARL members)." Collection Building 19, no. 3 (2000): 126–28. http://dx.doi.org/10.1108/cb.2000.19.3.126.1.

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8

Osorio, Nestor L. "Library Storage Facilities, Management and Services20011Jan Merrill‐Oldham, Jutta Reed‐Scott. Library Storage Facilities, Management and Services. Association of Research Libraries, Office of Leadership and Management Services, Washington, DC : SPEC Kits, 242 1999. 193 pp., ISBN: ISSN 01603582 $40.00 softcover Edited by Gary Gorman." Collection Building 20, no. 3 (2001): 146–48. http://dx.doi.org/10.1108/cb.2001.20.3.146.1.

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9

Venzin, Megan. "Apply the KISS Method." Special Events Galore 23, no. 7 (2023): 1. http://dx.doi.org/10.1002/speg.32000.

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10

Dias, Tarcisio. "Local wh-subjects under Quem nunca? ellipsis." Isogloss. Open Journal of Romance Linguistics 9, no. 4 (2023): 1–20. http://dx.doi.org/10.5565/rev/isogloss.295.

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In this paper I show that there is an elliptical construction in Brazilian Portuguese involving nunca ('never') restricted to locally moved wh-subjects and provide an account of this peculiar restriction. The construction in question corresponds to the sequence Quem nunca? ('Who never?'), which is used as a follow-up comment to a declarative sentence such as Pedro beijou João ('Pedro kissed João'), meaning 'Who did never kiss João?'. Curiously, the wh-element in such cases must correspond to the locally moved subject. I argue that the construction in question provides evidence for Bošković's (

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11

Nenn, Kerry. "Keep Kids Entertained at Grown-Up Events." Special Events Galore 16, no. 4 (2016): 1. http://dx.doi.org/10.1002/speg.30298.

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12

Nenn, Kerry. "Participants Go ‘Over the Edge’ for Kids." Special Events Galore 22, no. 12 (2022): 7. http://dx.doi.org/10.1002/speg.31888.

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13

Bigi, Nedeleg, Morgann Behrel, Kostia Roncin, et al. "Dynamic modeling of ships towed by kite." La Houille Blanche, no. 1 (February 2018): 8–10. http://dx.doi.org/10.1051/lhb/2018002.

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A dynamic kite flight can affect ship motions. Ship equations of motion associated with the analytical zero-mass kite model are developed. Aiming a realistic amplitude modeling of the kite excitation, a linear modification of the aerodynamic kite specs with the turning rate of the kite velocity heading is proposed. A good agreement with experimental data is obtained. Equations of motion are solved on a reaching path alternatively with a weak and a strong coupling between the ship and the kite. Differences between the two coupling methods become significant when a harmonic of the kite excitatio

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Nenn, Kerry. "Breakfast Allows Kids to Dress As Their Favorite Characters." Special Events Galore 23, no. 2 (2023): 3. http://dx.doi.org/10.1002/speg.31914.

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Nenn, Kerry. "‘Kids Diggin’ for a Cause' Gives Youngsters an Immersive Experience." Special Events Galore 24, no. 2 (2024): 5. http://dx.doi.org/10.1002/speg.32115.

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16

Sokołowski, Łukasz. "Serial jako element praktyk społecznych." Kultura i Społeczeństwo 55, no. 2-3 (2011): 187–208. http://dx.doi.org/10.35757/kis.2011.55.2-3.10.

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The purpose of the article is to show how the TV-series — one of the most importantforms of television production — is incorporated into the daily routines of the spec-tators. Michel de Certeau perspective of applied sociology of everyday life and criticalreflection on everyday life is used as a theoretical framework. In the case of TV-series,the routines can take a form of: (1) “logging in” and “reading”” TV-series, (2) movementand sociability routines, and (3) discursive development of received meanings. “Soapopera experience” consists mainly of linguistic practices cultivated while watching

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17

Ghoreishi, Seyedeh Masoumeh, Atena Najdian, Sina Yadegari, et al. "The Use of Carbon Quantum Dot as Alternative of Stannous Chloride Application in Radiopharmaceutical Kits." Contrast Media & Molecular Imaging 2020 (November 6, 2020): 1–11. http://dx.doi.org/10.1155/2020/4742158.

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Even today, technetium-99m is a radionuclide choice for diagnostic in nuclear medicine. The unique chemical and physical properties of technetium-99m make it suitable as an available radionuclide in many centers. In this study, we examined the potential of CQD as a reducing agent in the MDP kit. Citric acid-derived CQD was synthesized and confirmed by FT-IR, TEM, UV-Vis, XPS, and surface analysis. No cytotoxicity was observed by the MTT assay. They were reducing properties of the CQD confirmed by fluorescence microscopy. The MDP kit is prepared by evaluating different parameters that affect th

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18

De Martin, Benedito Wlademir, Teresinha Moraes Barreto Rockman, José Muradian, et al. "Avaliação experimental de "spect" cerebral mediante utilização do d,1 - HMPAO 99mTc em cães. Considerações anátomo-fisiológicas." Brazilian Journal of Veterinary Research and Animal Science 32, no. 1 (1995): 1. http://dx.doi.org/10.11606/issn.1678-4456.bjvras.1994.52081.

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O d,1 - Hexametilpropileno oxima marcado com o tecnécio-99m(99mTc-HMPAO) é um importante radiofármaco usado tanto para imagens tomográficas cerebrais quanto na marcação “in vitro" de leucócitos. A crescente utilização deste radiofármaco no estudo de doenças neurológicas no homem levou-nos à obtenção de "kits" de HMPAO para ser marcado pelo tecnécio-99m. Neste trabalho apresentamos o estudo experimental efetuado com "kits" liofilizados de d,1 – HMPAO99mTc desenvolvidos em nossos laboratórios, comparando inclusive com aqueles encontrados no comércio. As imagens cerebrais inicialmente foram feita

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19

Jeong, Seongkwon, and Jaejin Lee. "Iterative LDPC-SPC Product Code with LLR Controller for Bit-Patterned Media Recording." Journal of Korean Institute of Communications and Information Sciences 45, no. 2 (2020): 239–44. http://dx.doi.org/10.7840/kics.2020.45.2.239.

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20

Abouzayed, Ayman, Jesper Borin, Fanny Lundmark, et al. "The GRPR Antagonist [99mTc]Tc-maSSS-PEG2-RM26 towards Phase I Clinical Trial: Kit Preparation, Characterization and Toxicity." Diagnostics 13, no. 9 (2023): 1611. http://dx.doi.org/10.3390/diagnostics13091611.

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Gastrin-releasing peptide receptors (GRPRs) are overexpressed in the majority of primary prostate tumors and in prostatic lymph node and bone metastases. Several GRPR antagonists were developed for SPECT and PET imaging of prostate cancer. We previously reported a preclinical evaluation of the GRPR antagonist [99mTc]Tc-maSSS-PEG2-RM26 (based on [D-Phe6, Sta13, Leu14-NH2]BBN(6-14)) which bound to GRPR with high affinity and had a favorable biodistribution profile in tumor-bearing animal models. In this study, we aimed to prepare and test kits for prospective use in an early-phase clinical study

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21

Sheehan, Michelle. "Extraposition and antisymmetry." Linguistic Variation Yearbook 2010 10 (December 31, 2010): 201–51. http://dx.doi.org/10.1075/livy.10.06she.

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‘Extraposition’ is a cover term for two distinct phenomena (cf. also Fox & Nissenbaum 1999; Kiss 2005). The first, which I assume to be derived by parallel construal (following Koster 2000), targets only RCs, blocks reconstruction of the extraposed constituent to the base position of the source, and as such has the effect of bleeding condition C. The second, which I claim is derived via scattered deletion, targets post-head complements/modifiers, triggers obligatory reconstruction of the source+complement/modifier to base-position and leaves extraposed complements open to subextraction, al

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22

YAVUZ, Hatice Sümeyye, Müge ÖNER TAMAM, Halim OZCEVİK, Ahmet YAVUZ, and Mehmet MÜLAZIMOĞLU. "Evaluation of Tc-99m Labeled Erythrocyte Scintigraphy with SPECT/CT in the Diagnosis of Hepatic Hemangioma." İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, no. 19 (April 29, 2023): 98–109. http://dx.doi.org/10.38079/igusabder.1035135.

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Amaç: Günümüzde görüntüleme yöntemlerindeki gelişmeyle birlikte karaciğer hemanjiomlarının saptanması da artmıştır. Genellikle asemptomatik olan karaciğer hemanjiomlarının, karaciğerin diğer primer ve metastatik malign tümörlerinden ayırıcı tanısının konulması gerekmektedir. Özellikle boyutu küçük olan ve ana vasküler yapılara yakın olan lezyonların tanısını koymak önemlidir. Bu tip lezyonlar Tc-99m işaretli eritrosit sintigrafisi ile doğru olarak tanımlanabilir. Bu çalışmanın amacı karaciğer hemanjiomlarının Tc-99m işaretli eritrosit sintigrafisinin SPECT/BT ile değerlendirilmesi ve tanıya ol

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23

Vallejo-Armenta, Paola, Clara Santos-Cuevas, Juan Soto-Andonaegui, et al. "99mTc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans." Contrast Media & Molecular Imaging 2020 (April 27, 2020): 1–10. http://dx.doi.org/10.1155/2020/2525037.

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Overexpression of the chemokine-4 receptor (CXCR4) in brain tumors is associated with high cancer cell invasiveness. Recently, we reported the preclinical evaluation of 99mTc-CXCR4-L (cyclo-D-Tyr-D-[NMe]Orn[EDDA-99mTc-6-hydrazinylnicotinyl]-Arg-NaI-Gly) as a SPECT radioligand capable of specifically detecting the CXCR4 protein. This research aimed to estimate the biokinetic behavior and radiation dosimetry of 99mTc-CXCR4-L in healthy subjects, as well as to correlate the radiotracer uptake by brain tumors in patients, with the histological grade of differentiation and CXCR4 expression evaluate

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24

Negi, Meena, Vandana Kumar Dhingra, Manishi L. Narayan, et al. "Assessment of Indigenously Developed 99mTc-DTPA Bis-Methionine (99mTc-MDM) Qualitatively and Quantitatively During Initial Clinical Assessment in Breast Cancer Patients." European Journal of Medical and Health Research 3, no. 3 (2025): 65–69. https://doi.org/10.59324/ejmhr.2025.3(3).09.

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Introduction: Radionuclide-based tracers for SPECT and PET imaging have proven useful in the early detection of breast cancer. While C-11 methionine is an established PET tracer, its high cost and limited availability restrict its widespread clinical use. In contrast, 99mTc-MDM demonstrates promise as an alternative, with uptake facilitated by the overexpression of amino acid transporters, particularly via the LAT1 transporter in tumour cells. It is cost-effective and readily available, making it a potential candidate for identifying malignant breast lesions. Prior to administration, ensuring

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Abarquez, Dexter E. "The Plight of SPED Teachers: A Phenomenological Study." International Multidisciplinary Journal of Research for Innovation, Sustainability and Excellence (IMJRISE) 2, no. 5 (2025): 437–45. https://doi.org/10.5281/zenodo.15453839.

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<strong>Abstract:</strong>   Special Education (SPED) teachers play an important role in providing quality education to kids with a wide range of learning challenges. They do, however, encounter challenges that have an impact on their teaching efficacy, well-being, and professional development. These include insufficient resources, heavy workloads, emotional and mental stress, and inadequate support from officials and the community. Despite these experiences and challenges, SPED teachers remain committed to delivering inclusive and engaging learning experiences for their students. This st

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Dhingra, Vandana Kumar, Meena Negi, Puja Panwar Hazari, et al. "Quality Control Assessment and Biodistribution of Indigenously Developed [99mTc]DTPA-bis(ChoEA) During Initial Clinical Assessment as a Potential Imaging Agent for Prostate Cancer." European Journal of Theoretical and Applied Sciences 2, no. 6 (2024): 914–23. https://doi.org/10.59324/ejtas.2024.2(6).80.

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Introduction: SPECT and PET radiopharmaceuticals have been used in early diagnosis of prostate cancer. C-11 methionine is a PET tracer but it is expensive and not widely available in many centres. SPECT-based tracer [99mTc] DTPA-bis (ChoEA) has shown promising results with brain tumor imaging. The uptake of [99mTc] DTPA-bis (ChoEA) is facilitated by the up-regulation of amino acid transporters which has been observed in many tumor cells to facilitate these accelerated rates of amino acid uptake. It is readily available at low cost and could possibly have potential for detection of prostate can

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Vandana, Kumar Dhingra, Negi Meena, Panwar Hazari Puja, et al. "Quality Control Assessment and Biodistribution of Indigenously Developed [99mTc]DTPA-bis(ChoEA) During Initial Clinical Assessment as a Potential Imaging Agent for Prostate Cancer." European Journal of Theoretical and Applied Sciences 2, no. 6 (2024): 914–23. https://doi.org/10.59324/ejtas.2024.2(6).80.

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Introduction: SPECT and PET radiopharmaceuticals have been used in early diagnosis of prostate cancer. C-11 methionine is a PET tracer but it is expensive and not widely available in many centres. SPECT-based tracer [99mTc] DTPA-bis (ChoEA) has shown promising results with brain tumor imaging. The uptake of [99mTc] DTPA-bis (ChoEA) is facilitated by the up-regulation of amino acid transporters which has been observed in many tumor cells to facilitate these accelerated rates of amino acid uptake. It is readily available at low cost and could possibly have potential for detection of prostate can

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28

G, Gopi, and Edwin Prabakaran T. "A Study on Refractive Error in Patients of Chennai City in India during Covid 19 Pandemic Period." Indian Journal of Science and Technology 16, no. 17 (2023): 1250–59. https://doi.org/10.17485/IJST/v16i17.1308.

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Abstract <strong>Objectives:</strong> To compare the results of techniques Decision Tree, Discriminant, KNN, SVM applied to pre Covid-19 data collected in 2018 and data collected during Covid-19 pandemic period (2020) patients in Chennai city.<strong> Methods:</strong> The variables in the data are Refractive Error in both left and right eye, Age, Gender, Educational Status, Employment Status, Nature of Job, Working Hours, Working with Computer, Watching TV, Sleeping Hours, Type of Food, Extra Activity, Light in Residence, Light in Work Place, Family Members Wearing Specs, Paren

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Thakur, Riptee, Chandana Nagaraj, Raman Kumar Joshi, Jitender Saini, Ravi Yadav, and Pardeep Kumar. "Standardization and Clinical Use of a Single-vial Formulation of Technetium-99m-Trodat Using Autoclave Method." Indian Journal of Nuclear Medicine 39, no. 1 (2024): 18–23. http://dx.doi.org/10.4103/ijnm.ijnm_104_23.

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Background: Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra. SPECT imaging using technetium-99m [99mTc] labeled trodat is the choice of imaging to differentiate PD from its other forms like drug-induced PD. Aims and Objectives: The main objective of our study was to prepare in-house sterile formulation of [99mTc]Tc-trodat and use in clinics. Materials and Methods: The labeling of trodat was standardized using glucoheptonate sodium salt (GHA), stannous chloride dihydrate (in 0.05 N HCl), and ethylenediaminetetraacetic acid (Na-EDTA).

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Vallejo-Armenta, Paola, Guillermina Ferro-Flores, Clara Santos-Cuevas, et al. "[99mTc]Tc-iFAP/SPECT Tumor Stroma Imaging: Acquisition and Analysis of Clinical Images in Six Different Cancer Entities." Pharmaceuticals 15, no. 6 (2022): 729. http://dx.doi.org/10.3390/ph15060729.

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Fibroblast activation protein (FAP) is highly expressed on the cancer-associated fibroblasts (CAF) of the tumor stroma. Recently, we reported the preclinical evaluation and clinical biokinetics of a novel 99mTc-labeled FAP inhibitor radioligand ([99mTc]Tc-iFAP). This research aimed to evaluate [99mTc]Tc-iFAP for the tumor stroma imaging of six different cancerous entities and analyze them from the perspective of stromal heterogeneity. [99mTc]Tc-iFAP was prepared from freeze-dried kits with a radiochemical purity of 98 ± 1%. The study included thirty-two patients diagnosed with glioma (n = 5);

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Thakkar, Prashant V., Katsuhiro Kita, Urko del Castillo, et al. "Abstract 2623: Variants of CLIP-170 associated with taxane resistance in tumors." Cancer Research 82, no. 12_Supplement (2022): 2623. http://dx.doi.org/10.1158/1538-7445.am2022-2623.

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Abstract Despite its widespread use, the majority of patients with gastric cancer (GC) will not respond to taxane chemotherapy due to resistance mechanisms. Recently, we reported the discovery of a novel truncated variant of the microtubule plus-end binding protein CLIP-170, hereafter CLIP-170S, whose expression is enriched in taxane resistant cell lines and patients with GC. Mass-spec proteomics and 5’-RACE further showed that CLIP-170S lacked the first 155 amino acids, including the Cap-Gly motif required for microtubule plus-end localization. CLIP-170S knockdown reversed taxane resistance i

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Tamura, Naohisa, Erika Watanabe, Rumi Shirakawa, et al. "Comparisons of plasma aldosterone and renin data between an automated chemiluminescent immunoanalyzer and conventional radioimmunoassays in the screening and diagnosis of primary aldosteronism." PLOS ONE 16, no. 7 (2021): e0253807. http://dx.doi.org/10.1371/journal.pone.0253807.

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Determining values of plasma renin activity (PRA) or plasma active renin concentration (ARC), plasma aldosterone concentration (PAC), and aldosterone-to-renin ratio (ARR) is essential to diagnose primary aldosteronism (PA), but it takes several days with conventional radioimmunoassays (RIAs). Chemiluminescent enzyme immunoassays for PAC and ARC using the Accuraseed® immunoanalyzer facilitated the determination, but relations between Accuraseed® immunoanalyzer-based and RIA-based values in samples of PA confirmatory tests and adrenal venous sampling remained to be elucidated. We addressed this

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Nolasco, Marita Nimiah P. "SPED Teachers’ Extent of Implementing Picture Exchange Communication System: It’s Effect on the Functional Communication Skills of Learners with Down Syndrome." International Journal of Multidisciplinary: Applied Business and Education Research 3, no. 9 (2022): 1812–20. http://dx.doi.org/10.11594/ijmaber.03.09.21.

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People with limited or no communication skills can use the Picture Exchange Communication System, or PECS, to communicate visually. Based on an evaluation of the functional communication skills of students with Down syndrome, this study investigated the profile of the respondents, the respondents' level of implementation of the Picture Exchange Communication System for students with Down Syndrome, the level of effectiveness of using the Picture Exchange Communication System, and the connection between these variables. The descriptive correlational research method was used for the study. The st

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Liu, Zhen-huan, Yan-chao Qi, Pei-guang Pan, et al. "Clinical observation on effect of clearing the governor vessel and refreshing the mind needling on head SPECT and CT scanning of kids with cerebral palsy." Journal of Acupuncture and Tuina Science 5, no. 4 (2007): 209–12. http://dx.doi.org/10.1007/s11726-007-0210-6.

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Elbadawi Hussien, Mohamed Elmekki Ali. "Bird Electrocution and Collisions with Power Infrastructure in Elgazeira, Kassala and Gadarif States, Sudan." Open Access Journal of Veterinary Science & Research 3, no. 4 (2018): 1–8. http://dx.doi.org/10.23880/oajvsr-16000166.

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This study was conduct ed at Elgazeira, kassala and Gadarif states, covered two seasons in exception of Gadarif state studied in the last season only. The first season from 28/6/2015 to 6/7/2015, and another season from 24 December 2015 - 6 January 2016, to assess the bird's mort ality caused by the power lines . Objectives of this study are: Describe types of killer power lines, and determine numbers of bird species, that are killed by collisions or electrocutions. There were 43 lines traversed in the study area, as follow: 20 line s in the Gaziera state, 9 lines in Gadarif and 14 in kassala.

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Ezeana, Chika F., Tiancheng He, Tejal A. Patel, et al. "Abstract 5698: A multicenter study validated an integrated deep learning model for precision malignancy risk assessment and reducing unnecessary biopsies in BI-RADS 4 cases." Cancer Research 83, no. 7_Supplement (2023): 5698. http://dx.doi.org/10.1158/1538-7445.am2023-5698.

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Abstract Introduction: BI-RADS category 4 is associated with a wide variability in probability of malignancy, ranging from 2 to 95% while biopsy-derived positive predictive value (PPV3) for this category’s lesions remains low at 21.1% in the US. A major fallout of these facts is that we have way very high false positive rate leading to too many unnecessary biopsies and their associated costs and emotional burden. We improved our in-house intelligent-augmented Breast cancer RISK calculator (iBRISK), an integrated deep learning (DL) based decision support app and assessed its performance in a mu

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Nandakumar, Bharat, David L. Murray, Angela Dispenzieri, et al. "Sequential Comparison of Conventional Serum Immunofixation (IFE) to Mass Spectrometry-Based Assessment (MASS FIX) in Patients with Multiple Myeloma (MM)." Blood 136, Supplement 1 (2020): 12–13. http://dx.doi.org/10.1182/blood-2020-141342.

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Background: The absence of residual monoclonal protein in the serum and urine by IFE using specific antibodies to individual heavy and light chains has been an important part of response assessment and is required for categorizing patients as in complete response. MASS FIX has been shown to be more sensitive in picking up small amounts of monoclonal protein and represents an advancement in the field. Ongoing studies are examining the clinical significance of this increased sensitivity. We designed the following study using clinically obtained test results to examine this question. Patients and

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Mellors, Patrick, Surendra Dasari, Mindy Kohlhagen, et al. "MASS-FIX for the Diagnosis of Plasma Cell Disorders: A Single Institution Experience of 4118 Patients." Blood 136, Supplement 1 (2020): 48–49. http://dx.doi.org/10.1182/blood-2020-138829.

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Introduction: Since 2018, immunoenrichment-based matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), termed MASS-FIX, has replaced immunofixation for the detection and isotyping of serum monoclonal proteins at Mayo Clinic. MASS-FIX has advantages including increased sensitivity, specificity, and the ability to distinguish therapeutic monoclonal antibodies. Herein, we report the laboratory characteristics and distribution of diagnoses of patients tested clinically at Mayo Clinic. Methods: MASS-FIX was performed on patient samples as previously described

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Lacy, Martha Q., Kah-Whye Peng, Stephen J. Russell, et al. "Phase I Trial of Systemic Administration of Vesicular Stomatitis Virus Genetically Engineered to Express NIS and Human Interferon, in Patients with Relapsed or Refractory Multiple Myeloma (MM), Acute Myeloid Leukemia (AML), and T-Cell Neoplasms (TCL)." Blood 132, Supplement 1 (2018): 3268. http://dx.doi.org/10.1182/blood-2018-99-119444.

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Abstract Background: We previously reported successful treatment of myeloma with an oncolytic virus, MMV-NIS. Preexisting immunity against measles made use of that virus unsatisfactory. The Indiana strain of Vesicular Stomatitis Viruses (VSV) are being developed as anticancer drugs for the treatment of a variety of malignancies. To ensure tumor selective replication and spread, we designed the VSV to encode interferon beta. Expression of IFNβ also serves as a STING agonist to activate host immunity against the cancer. The sodium iodide symporter (NIS) is inserted as a reporter gene into the vi

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Mellors, Patrick, Surendra Dasari, Mindy Kohlhagen, et al. "A Cross Sectional Evaluation of Light Chain N-Glycosylation By MASS-FIX in Plasma Cell Disorders." Blood 136, Supplement 1 (2020): 44–45. http://dx.doi.org/10.1182/blood-2020-142601.

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Introduction: Since 2018, immunoenrichment-based matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), termed MASS-FIX, has replaced standard gel-based immunofixation for the detection and isotyping of serum monoclonal proteins at Mayo Clinic. MASS-FIX can readily identify N-glycosylation of involved light chains (LC N-glycosylation) by its unique, polytypic spectral pattern. LC N-glycosylation is identified more commonly in light chain amyloidosis (AL) than other plasma cell disorders (PCDs), and is associated with an increased risk of progression from M

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Ezeana, Chika, Xiaohui Yu, Zhihao Wan, et al. "Abstract PO2-28-06: An on-line deep learning decision support tool, iBRISK, aimed at improving breast cancer risk estimation and reducing unnecessary biopsies for BI-RADS 4 patients." Cancer Research 84, no. 9_Supplement (2024): PO2–28–06—PO2–28–06. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-28-06.

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Abstract Probability of malignancy (POM) for Breast Imaging Reporting and Data System (BI-RADS) category 4 designated breast lesions ranges from 2% – 95% and contributes to a high unnecessary biopsy rate. This is as most clinicians often stick to the biopsy option to rule in or out breast cancer early; withholding biopsy could be risky, and biopsies of BI-RADS 4 lesions serve as a quality metric and performance standard. At 21.1%, biopsy-proven positive predictive value (PPV3) rates for BI-RADS 4 have not improved for decades, translating to high false-positive rates of mammography. Unnecessar

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Vachon, Celine M., Josiah Murray, Cristine Allmer, et al. "Comparison of MGUS Prevalence By Race and Family History Risk Groups Using a High Sensitivity Screening Method (MASS-FIX)." Blood 136, Supplement 1 (2020): 40–41. http://dx.doi.org/10.1182/blood-2020-142583.

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Introduction Monoclonal gammopathy of undetermined significant (MGUS) is a premalignant plasma cell disorder that is common in individuals over age 50. MGUS prevalence estimates to date have generally been based on results of serum electrophoresis and immunofixation (for heavy chain [HC] MGUS) and additionally, free light chain (for light chain [LC] MGUS). Mass-spectrometry assays, however, can detect lower levels of monoclonal (M) proteins, identify the isotype and provide accurate quantification of the M-protein. Given the evidence that MGUS is likely present at least 10 years prior to its d

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Cook, Joselle, Kah-Whye Peng, Brenda F. Ginos, et al. "Phase I Trial of Systemic Administration of Vesicular Stomatitis Virus Genetically Engineered to Express NIS and Human Interferon Beta, in Patients with Relapsed or Refractory Multiple Myeloma (MM), Acute Myeloid Leukemia (AML), and T-Cell Neoplasms (TCL)." Blood 136, Supplement 1 (2020): 7–8. http://dx.doi.org/10.1182/blood-2020-140853.

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Background: Oncolytic virotherapy is a novel immunomodulatory therapeutic approach for relapsed refractory hematologic malignancies. The Indiana strain of Vesicular Stomatitis Virus (VSV) has been engineered to encode interferon beta (IFNβ) and sodium iodine symporter (NIS) to produce VSV-IFNβ-NIS. The virally encoded IFNβ serves as an index of viral proliferation and enhances host anti-tumor immunity. The NIS is inserted as a reporter gene into the viral genome to enable noninvasive monitoring of viral spread using PET/CT imaging. Here we present results of Arm A (patients with low tumor burd

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Daivik, Jigar, Mayur Jethva, and Pooja Rohit. "RAPID ANTIGEN DETECTION KIT AS A DIAGNOSTIC TOOL FOR SARS COV-2." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, October 1, 2024, 79–80. http://dx.doi.org/10.36106/ijsr/2816260.

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Background: The rst case of SARS CoV2 was detected in December 2019 from Wuhan city of China and in January 2020 from India. Since then, COVID-19 disease was rapidly spread out to all over the world and presented as severe pandemic. Real time RT-PCR is the gold standard frontline test for diagnosis of COVID-19 disease, caused by SARS-CoV-2 virus but it is time consuming and requires specialized laboratory facilities interms of equipment, biosafety & biosecurity. Material & Methods: This retrospective study was undertaken from duration of June 2020 to October 2021 at B.J Medical colleg

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Pavlenko, E. P., A. O. Malysheva, and A. A. Larenkov. "Pharmaceutical development and practical approach to synthesis of tropantiol radiopharmaceutical ([99mTc]Tc-TRODAT-1) for diagnostic of neurodegenerative diseases (review)." Drug development & registration, December 13, 2024. https://doi.org/10.33380/2305-2066-2025-14-1-1882.

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Introduction. The symptoms of Parkinson's disease are mainly associated with the formation of intraneuronal protein inclusions with Lewy bodies, and the progressive loss of dopaminergic neurons of the Substantia nigra and their axons. Existing diagnostic criteria for the diagnosis of Parkinson's disease often take into account symptoms occurring in the later stages of the disease. Thus, for a more accurate diagnosis in the early stages, it is necessary to confirm pathologic changes in brain tissue by molecular imaging methods such as positron emission tomography (PET) and single-photon emissio

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M R, Shincy, Vandana Govindan, Sudhakar H H, Padmapriya K, Venkatesha V T, and K. L. Ravikumar. "COMPARISON OF PERFORMANCE CHARACTERISTICS BETWEEN LATERAL FLOW, ELISAAND ELECTROCHEMILUMINESCENCE IMMUNOASSAYS FOR THE DETECTION OF SARS-COV-2 ANTIBODIES AMONG HEALTHCARE WORKERS." INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, July 1, 2021, 45–48. http://dx.doi.org/10.36106/ijsr/0101617.

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Background: The detection of SARS-CoV-2 IgG is important to determine the course of COVID-19. Medical professionals and researchers have been urging the need for wide and rapid testing of citizens in order to plan measures that can contain the spread of the virus. Antibody tests play an important role throughout the patient care pathway and are vital for the management and surveillance of the virus. Although RTPCR is considered to be the gold standard, serological tests based on antibodies could be very helpful for on-time detection. We performed one to one assessment of electrochemiluminescen

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"Children's Museum Hosts ‘Golf Fore Kids’." Special Events Galore 17, no. 2 (2017): 5. http://dx.doi.org/10.1002/speg.30507.

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"Men in Kilts: A Fun Crowdfunding Campaign." Special Events Galore 19, no. 9 (2019): 7. http://dx.doi.org/10.1002/speg.31187.

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"Follow the KISS Model: “Keep It Simply Sustainable”." Special Events Galore 22, no. 10 (2022): 4. http://dx.doi.org/10.1002/speg.31850.

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"Downright Beautiful Fashion Show Features Down Syndrome Kids." Special Events Galore 18, no. 1 (2017): 7. http://dx.doi.org/10.1002/speg.30744.

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