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1

Yuan, Ling, and Erich Grotewold. "Plant specialized metabolism." Plant Science 298 (September 2020): 110579. http://dx.doi.org/10.1016/j.plantsci.2020.110579.

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2

Huang, Xing-Qi, and Natalia Dudareva. "Plant specialized metabolism." Current Biology 33, no. 11 (2023): R473—R478. http://dx.doi.org/10.1016/j.cub.2023.01.057.

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3

Tholl, Dorothea, and Sungbeom Lee. "Terpene Specialized Metabolism inArabidopsis thaliana." Arabidopsis Book 9 (January 2011): e0143. http://dx.doi.org/10.1199/tab.0143.

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4

Tobias, Nicholas J., and Helge B. Bode. "Heterogeneity in Bacterial Specialized Metabolism." Journal of Molecular Biology 431, no. 23 (2019): 4589–98. http://dx.doi.org/10.1016/j.jmb.2019.04.042.

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5

LI, HaoXun, and GuoDong WANG. "Specialized Metabolism in Plant Glandular Trichomes." SCIENTIA SINICA Vitae 45, no. 6 (2015): 557–68. http://dx.doi.org/10.1360/n052015-00073.

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6

Pichersky, Eran, and Efraim Lewinsohn. "Convergent Evolution in Plant Specialized Metabolism." Annual Review of Plant Biology 62, no. 1 (2011): 549–66. http://dx.doi.org/10.1146/annurev-arplant-042110-103814.

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7

Nützmann, Hans-Wilhelm, and Anne Osbourn. "Gene clustering in plant specialized metabolism." Current Opinion in Biotechnology 26 (April 2014): 91–99. http://dx.doi.org/10.1016/j.copbio.2013.10.009.

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8

Durán-Medina, Yolanda, Beatriz Esperanza Ruiz-Cortés, Herenia Guerrero-Largo, and Nayelli Marsch-Martínez. "Specialized metabolism and development: An unexpected friendship." Current Opinion in Plant Biology 64 (December 2021): 102142. http://dx.doi.org/10.1016/j.pbi.2021.102142.

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9

Chen, Xueying, Dan-Dan Wang, Xin Fang, Xiao-Ya Chen, and Ying-Bo Mao. "Plant Specialized Metabolism Regulated by Jasmonate Signaling." Plant and Cell Physiology 60, no. 12 (2019): 2638–47. http://dx.doi.org/10.1093/pcp/pcz161.

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Abstract As sessile and autotrophic organisms, plants have evolved sophisticated pathways to produce a rich array of specialized metabolites, many of which are biologically active and function as defense substances in protecting plants from herbivores and pathogens. Upon stimuli, these structurally diverse small molecules may be synthesized or constitutively accumulated. Jasmonate acids (JAs) are the major defense phytohormone involved in transducing external signals (such as wounding) to activate defense reactions, including, in particular, the reprogramming of metabolic pathways that initiat
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10

Chae, L., T. Kim, R. Nilo-Poyanco, and S. Y. Rhee. "Genomic Signatures of Specialized Metabolism in Plants." Science 344, no. 6183 (2014): 510–13. http://dx.doi.org/10.1126/science.1252076.

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11

Louveau, Thomas, and Anne Osbourn. "The Sweet Side of Plant-Specialized Metabolism." Cold Spring Harbor Perspectives in Biology 11, no. 12 (2019): a034744. http://dx.doi.org/10.1101/cshperspect.a034744.

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12

Colinas, Maite, and Alain Goossens. "Combinatorial Transcriptional Control of Plant Specialized Metabolism." Trends in Plant Science 23, no. 4 (2018): 324–36. http://dx.doi.org/10.1016/j.tplants.2017.12.006.

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13

Colinas, Maite, and Teresa B. Fitzpatrick. "Coenzymes and the primary and specialized metabolism interface." Current Opinion in Plant Biology 66 (April 2022): 102170. http://dx.doi.org/10.1016/j.pbi.2021.102170.

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14

Kalimullin, Marat, Sai-Suu Sadi, Aleksandr Avstriyevskikh, and Valeriy Poznyakovskiy. "Specialized Food Product for Carbohydrate Metabolism Disorders Correction." Food Industry 4, no. 3 (2019): 58–64. http://dx.doi.org/10.29141/2500-1922-2019-4-3-7.

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15

Lu, Shan. "Plant Specialized Metabolism: the Easy and the Hard." Journal of Integrative Plant Biology 52, no. 10 (2010): 854–55. http://dx.doi.org/10.1111/j.1744-7909.2010.00997.x.

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16

Weng, J. K., and J. P. Noel. "The Remarkable Pliability and Promiscuity of Specialized Metabolism." Cold Spring Harbor Symposia on Quantitative Biology 77 (January 1, 2012): 309–20. http://dx.doi.org/10.1101/sqb.2012.77.014787.

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17

Gutierrez, Eugenio, David Wiggins, Barbara Fielding, and Alex P. Gould. "Specialized hepatocyte-like cells regulate Drosophila lipid metabolism." Nature 445, no. 7125 (2006): 275–80. http://dx.doi.org/10.1038/nature05382.

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18

Daloso, Danilo M., David B. Medeiros, Letícia dos Anjos, Takuya Yoshida, Wagner L. Araújo, and Alisdair R. Fernie. "Metabolism within the specialized guard cells of plants." New Phytologist 216, no. 4 (2017): 1018–33. http://dx.doi.org/10.1111/nph.14823.

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19

Schluttenhofer, Craig, and Ling Yuan. "Regulation of Specialized Metabolism by WRKY Transcription Factors." Plant Physiology 167, no. 2 (2014): 295–306. http://dx.doi.org/10.1104/pp.114.251769.

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20

Wilson, Alexander E., Hosea D. Matel, and Li Tian. "Glucose ester enabled acylation in plant specialized metabolism." Phytochemistry Reviews 15, no. 6 (2016): 1057–74. http://dx.doi.org/10.1007/s11101-016-9467-z.

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21

Kreis, Wolfgang, and Jennifer Munkert. "Exploiting enzyme promiscuity to shape plant specialized metabolism." Journal of Experimental Botany 70, no. 5 (2019): 1435–45. http://dx.doi.org/10.1093/jxb/erz025.

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22

Xu, Jing-Jing, Xin Fang, Chen-Yi Li, Lei Yang, and Xiao-Ya Chen. "General and specialized tyrosine metabolism pathways in plants." aBIOTECH 1, no. 2 (2019): 97–105. http://dx.doi.org/10.1007/s42994-019-00006-w.

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23

Chakraborty, Prasanta. "Gene Clusters from Plants to Microbes: Their Role in Specialized Metabolism and Drug Development." International Journal of Pharmacognosy & Chinese Medicine 2, no. 5 (2018): 1–2. http://dx.doi.org/10.23880/ipcm-16000149.

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24

Lacchini, Elia, and Alain Goossens. "Combinatorial Control of Plant Specialized Metabolism: Mechanisms, Functions, and Consequences." Annual Review of Cell and Developmental Biology 36, no. 1 (2020): 291–313. http://dx.doi.org/10.1146/annurev-cellbio-011620-031429.

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Plants constantly perceive internal and external cues, many of which they need to address to safeguard their proper development and survival. They respond to these cues by selective activation of specific metabolic pathways involving a plethora of molecular players that act and interact in complex networks. In this review, we illustrate and discuss the complexity in the combinatorial control of plant specialized metabolism. We hereby go beyond the intuitive concept of combinatorial control as exerted by modular-acting complexes of transcription factors that govern expression of specialized met
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25

Panda, Sayantan, Yana Kazachkova, and Asaph Aharoni. "Catch-22 in specialized metabolism: balancing defense and growth." Journal of Experimental Botany 72, no. 17 (2021): 6027–41. http://dx.doi.org/10.1093/jxb/erab348.

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Abstract Plants are unsurpassed biochemists that synthesize a plethora of molecules in response to an ever-changing environment. The majority of these molecules, considered as specialized metabolites, effectively protect the plant against pathogens and herbivores. However, this defense most probably comes at a great expense, leading to reduction of growth (known as the ‘growth–defense trade-off’). Plants employ several strategies to reduce the high metabolic costs associated with chemical defense. Production of specialized metabolites is tightly regulated by a network of transcription factors
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26

Kamdem, Ramsay Soup Teoua, Omonike Ogbole, Pascal Wafo, et al. "Rational engineering of specialized metabolites in bacteria and fungi." Physical Sciences Reviews 6, no. 5 (2021): 9–26. http://dx.doi.org/10.1515/psr-2018-0170.

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Abstract Bacteria and fungi have a high potential to produce compounds that display large structural change and diversity, thus displaying an extensive range of biological activities. Secondary metabolism or specialized metabolism is a term for pathways and small molecule products of metabolism that are not mandatory for the subsistence of the organism but improve and control their phenotype. Their interesting biological activities have occasioned their application in the fields of agriculture, food, and pharmaceuticals. Metabolic engineering is a powerful approach to improve access to these t
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27

Beilsmith, Kathleen, Christopher S. Henry, and Samuel M. ,. D. Seaver. "Genome-scale modeling of the primary-specialized metabolism interface." Current Opinion in Plant Biology 68 (August 2022): 102244. http://dx.doi.org/10.1016/j.pbi.2022.102244.

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28

Letzel, Anne-Catrin, Jing Li, Gregory C. A. Amos, et al. "Genomic insights into specialized metabolism in the marine actinomyceteSalinispora." Environmental Microbiology 19, no. 9 (2017): 3660–73. http://dx.doi.org/10.1111/1462-2920.13867.

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29

Moore, Bethany M., Peipei Wang, Pengxiang Fan, et al. "Robust predictions of specialized metabolism genes through machine learning." Proceedings of the National Academy of Sciences 116, no. 6 (2019): 2344–53. http://dx.doi.org/10.1073/pnas.1817074116.

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Plant specialized metabolism (SM) enzymes produce lineage-specific metabolites with important ecological, evolutionary, and biotechnological implications. UsingArabidopsis thalianaas a model, we identified distinguishing characteristics of SM and GM (general metabolism, traditionally referred to as primary metabolism) genes through a detailed study of features including duplication pattern, sequence conservation, transcription, protein domain content, and gene network properties. Analysis of multiple sets of benchmark genes revealed that SM genes tend to be tandemly duplicated, coexpressed wit
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30

Leong, Bryan J., Steven M. Hurney, Paul D. Fiesel, Gaurav D. Moghe, A. Daniel Jones, and Robert L. Last. "Specialized Metabolism in a Nonmodel Nightshade: Trichome Acylinositol Biosynthesis." Plant Physiology 183, no. 3 (2020): 915–24. http://dx.doi.org/10.1104/pp.20.00276.

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31

HIGASHI, YASUHIRO, and KAZUKI SAITO. "Network analysis for gene discovery in plant-specialized metabolism." Plant, Cell & Environment 36, no. 9 (2013): 1597–606. http://dx.doi.org/10.1111/pce.12069.

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32

Sørensen, Mette, Elizabeth H. J. Neilson, and Birger Lindberg Møller. "Oximes: Unrecognized Chameleons in General and Specialized Plant Metabolism." Molecular Plant 11, no. 1 (2018): 95–117. http://dx.doi.org/10.1016/j.molp.2017.12.014.

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33

Laursen, Tomas, Birger Lindberg Møller, and Jean-Etienne Bassard. "Plasticity of specialized metabolism as mediated by dynamic metabolons." Trends in Plant Science 20, no. 1 (2015): 20–32. http://dx.doi.org/10.1016/j.tplants.2014.11.002.

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34

Rai, Amit, Kazuki Saito, and Mami Yamazaki. "Integrated omics analysis of specialized metabolism in medicinal plants." Plant Journal 90, no. 4 (2017): 764–87. http://dx.doi.org/10.1111/tpj.13485.

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35

Leong, Bryan J., and Robert L. Last. "Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism." Current Opinion in Structural Biology 47 (December 2017): 105–12. http://dx.doi.org/10.1016/j.sbi.2017.07.005.

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36

Banerjee, Aparajita, and Björn Hamberger. "P450s controlling metabolic bifurcations in plant terpene specialized metabolism." Phytochemistry Reviews 17, no. 1 (2017): 81–111. http://dx.doi.org/10.1007/s11101-017-9530-4.

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37

Nishimura, Taki, and Christopher J. Stefan. "Specialized ER membrane domains for lipid metabolism and transport." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865, no. 1 (2020): 158492. http://dx.doi.org/10.1016/j.bbalip.2019.07.001.

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38

Desmet, Sandrien, Kris Morreel, and Rebecca Dauwe. "Origin and Function of Structural Diversity in the Plant Specialized Metabolome." Plants 10, no. 11 (2021): 2393. http://dx.doi.org/10.3390/plants10112393.

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The plant specialized metabolome consists of a multitude of structurally and functionally diverse metabolites, variable from species to species. The specialized metabolites play roles in the response to environmental changes and abiotic or biotic stresses, as well as in plant growth and development. At its basis, the specialized metabolism is built of four major pathways, each starting from a few distinct primary metabolism precursors, and leading to distinct basic carbon skeleton core structures: polyketides and fatty acid derivatives, terpenoids, alkaloids, and phenolics. Structural diversit
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39

Moing, Annick, Pierre Pétriacq, and Sonia Osorio. "Special Issue on “Fruit Metabolism and Metabolomics”." Metabolites 10, no. 6 (2020): 230. http://dx.doi.org/10.3390/metabo10060230.

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Over the past 10 years, knowledge about several aspects of fruit metabolism has been greatly improved. Notably, high-throughput metabolomic technologies have allowed quantifying metabolite levels across various biological processes, and identifying the genes that underly fruit development and ripening. This Special Issue is designed to exemplify the current use of metabolomics studies of temperate and tropical fruit for basic research as well as practical applications. It includes articles about different aspects of fruit biochemical phenotyping, fruit metabolism before and after harvest, incl
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40

Weng, Jing-Ke, Joseph H. Lynch, Jason O. Matos, and Natalia Dudareva. "Adaptive mechanisms of plant specialized metabolism connecting chemistry to function." Nature Chemical Biology 17, no. 10 (2021): 1037–45. http://dx.doi.org/10.1038/s41589-021-00822-6.

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41

Murphy, Katherine M., and Philipp Zerbe. "Specialized diterpenoid metabolism in monocot crops: Biosynthesis and chemical diversity." Phytochemistry 172 (April 2020): 112289. http://dx.doi.org/10.1016/j.phytochem.2020.112289.

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42

Ube, Naoki, Miho Nishizaka, Tsuyoshi Ichiyanagi, Kotomi Ueno, Shin Taketa, and Atsushi Ishihara. "Evolutionary changes in defensive specialized metabolism in the genus Hordeum." Phytochemistry 141 (September 2017): 1–10. http://dx.doi.org/10.1016/j.phytochem.2017.05.004.

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43

Wager, Amanda, and Xu Li. "Exploiting natural variation for accelerating discoveries in plant specialized metabolism." Phytochemistry Reviews 17, no. 1 (2017): 17–36. http://dx.doi.org/10.1007/s11101-017-9524-2.

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44

Patin, Nastassia V., Dimitrios J. Floros, Chambers C. Hughes, Pieter C. Dorrestein, and Paul R. Jensen. "The role of inter-species interactions in Salinispora specialized metabolism." Microbiology 164, no. 7 (2018): 946–55. http://dx.doi.org/10.1099/mic.0.000679.

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45

Wehr, John D., Lewis M. Brown, and Kathryn O'Grady. "Highly Specialized Nitrogen Metabolism in a Freshwater Phytoplankter, Chrysochromulina breviturrita." Canadian Journal of Fisheries and Aquatic Sciences 44, no. 4 (1987): 736–42. http://dx.doi.org/10.1139/f87-089.

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A field and laboratory culture study was carried out on the nitrogen metabolism of isolates of the freshwater phytoplankter Chrysochromulina breviturrita Nich. (Prymnesiophyceae). These were isolated from two different softwater lakes, one believed to be influenced by acidic precipitation (Cinder Lake) and another which was experimentally acidified with H2SO4 (Lake 302-South). The alga was able to utilize only NH4+ as an inorganic N source. A range of irradiances and molybdenum concentrations failed to induce NO3− utilization. Among 17 organic N compounds including amino acids, purines, and ot
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46

Calderin, Ernesto Pena, Lindsey McNally, Bradford G. Hill, and Jason Hellmann. "Specialized pro-resolving lipid mediators stimulate mitochondrial metabolism in macrophages." Journal of Immunology 206, no. 1_Supplement (2021): 97.09. http://dx.doi.org/10.4049/jimmunol.206.supp.97.09.

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Abstract Chronic inflammation and sustained recruitment of classically activated macrophages (CAMs) with unchecked pro-inflammatory cytokine production is associated with disease development (e.g., atherosclerosis). Pro-inflammatory actions of CAMs are fueled by enhanced glycolysis and disruptions in the TCA cycle. Conversely, alternatively activated macrophages (AAMs) display an intact TCA cycle and mitochondrial oxidative phosphorylation (OXPHOS). Specialized pro-resolving lipid mediators (SPMs) stimulate resolution, in part, through actions on specific G-protein coupled receptors (GPCRs) in
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47

Jacobowitz, Joseph R., and Jing-Ke Weng. "Exploring Uncharted Territories of Plant Specialized Metabolism in the Postgenomic Era." Annual Review of Plant Biology 71, no. 1 (2020): 631–58. http://dx.doi.org/10.1146/annurev-arplant-081519-035634.

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For millennia, humans have used plants for food, raw materials, and medicines, but only within the past two centuries have we begun to connect particular plant metabolites with specific properties and utilities. Since the utility of classical molecular genetics beyond model species is limited, the vast specialized metabolic systems present in the Earth's flora remain largely unstudied. With an explosion in genomics resources and a rapidly expanding toolbox over the past decade, exploration of plant specialized metabolism in nonmodel species is becoming more feasible than ever before. We review
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48

Lin, Gonghua, Zuhao Huang, Bo He, Kai Jiang, Tianjuan Su, and Fang Zhao. "Evolutionary Adaptation of Genes Involved in Galactose Derivatives Metabolism in Oil-Tea Specialized Andrena Species." Genes 14, no. 5 (2023): 1117. http://dx.doi.org/10.3390/genes14051117.

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Oil-tea (Camellia oleifera) is a woody oil crop whose nectar includes galactose derivatives that are toxic to honey bees. Interestingly, some mining bees of the genus Andrena can entirely live on the nectar (and pollen) of oil-tea and are able to metabolize these galactose derivatives. We present the first next-generation genomes for five and one Andrena species that are, respectively, specialized and non-specialized oil-tea pollinators and, combining these with the published genomes of six other Andrena species which did not visit oil-tea, we performed molecular evolution analyses on the gene
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49

Vorobyeva, Valentina, Irina Vorobyeva, Alla Kochetkova, Vladimir Mazo, Sergey Zorin, and Khaider Sharafetdinov. "Specialized hypocholesterolemic foods: Ingredients, technology, effects." Foods and Raw Materials 8, no. 1 (2020): 20–29. http://dx.doi.org/10.21603/2308-4057-2020-1-20-29.

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Introduction. Overweight and obesity are leading risk factors for metabolic syndrome (MS). From 20 to 35% of Russian people have this condition, depending on their age. MS is a precursor of cardiovascular disease, diabetes mellitus, diabetic nephropathy, and nonalcoholic steatohepatitis. Specialized foods (SFs) with hypocholesteremic effects are an important component of the diet therapy for MS patients. Creating local SFs to optimize the nutritional status of MS patients and prevent related diseases is a highly promising area of research. The aim of our study was to develop the formulation an
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50

Weng, Jing-Ke, Ryan N. Philippe, and Joseph P. Noel. "The Rise of Chemodiversity in Plants." Science 336, no. 6089 (2012): 1667–70. http://dx.doi.org/10.1126/science.1217411.

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Plants possess multifunctional and rapidly evolving specialized metabolic enzymes. Many metabolites do not appear to be immediately required for survival; nonetheless, many may contribute to maintaining population fitness in fluctuating and geographically dispersed environments. Others may serve no contemporary function but are produced inevitably as minor products by single enzymes with varying levels of catalytic promiscuity. The dominance of the terrestrial realm by plants likely mirrored expansion of specialized metabolism originating from primary metabolic pathways. Compared with their ev
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