Relevant bibliographies by topics / Specialized metabolite

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Specialized metabolite'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Specialized metabolite.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Specialized metabolite"

1

Panda, Sayantan, Yana Kazachkova, and Asaph Aharoni. "Catch-22 in specialized metabolism: balancing defense and growth." Journal of Experimental Botany 72, no. 17 (July 22, 2021): 6027–41. http://dx.doi.org/10.1093/jxb/erab348.

Full text
Abstract:
Abstract Plants are unsurpassed biochemists that synthesize a plethora of molecules in response to an ever-changing environment. The majority of these molecules, considered as specialized metabolites, effectively protect the plant against pathogens and herbivores. However, this defense most probably comes at a great expense, leading to reduction of growth (known as the ‘growth–defense trade-off’). Plants employ several strategies to reduce the high metabolic costs associated with chemical defense. Production of specialized metabolites is tightly regulated by a network of transcription factors facilitating its fine-tuning in time and space. Multifunctionality of specialized metabolites—their effective recycling system by re-using carbon, nitrogen, and sulfur, thus re-introducing them back to the primary metabolite pool—allows further cost reduction. Spatial separation of biosynthetic enzymes and their substrates, and sequestration of potentially toxic substances and conversion to less toxic metabolite forms are the plant’s solutions to avoid the detrimental effects of metabolites they produce as well as to reduce production costs. Constant fitness pressure from herbivores, pathogens, and abiotic stressors leads to honing of specialized metabolite biosynthesis reactions to be timely, efficient, and metabolically cost-effective. In this review, we assess the costs of production of specialized metabolites for chemical defense and the different plant mechanisms to reduce the cost of such metabolic activity in terms of self-toxicity and growth.
APA, Harvard, Vancouver, ISO, and other styles
2

Rai, Megha, Amit Rai, Tetsuya Mori, Ryo Nakabayashi, Manami Yamamoto, Michimi Nakamura, Hideyuki Suzuki, Kazuki Saito, and Mami Yamazaki. "Gene-Metabolite Network Analysis Revealed Tissue-Specific Accumulation of Therapeutic Metabolites in Mallotus japonicus." International Journal of Molecular Sciences 22, no. 16 (August 17, 2021): 8835. http://dx.doi.org/10.3390/ijms22168835.

Full text
Abstract:
Mallotus japonicus is a valuable traditional medicinal plant in East Asia for applications as a gastrointestinal drug. However, the molecular components involved in the biosynthesis of bioactive metabolites have not yet been explored, primarily due to a lack of omics resources. In this study, we established metabolome and transcriptome resources for M. japonicus to capture the diverse metabolite constituents and active transcripts involved in its biosynthesis and regulation. A combination of untargeted metabolite profiling with data-dependent metabolite fragmentation and metabolite annotation through manual curation and feature-based molecular networking established an overall metabospace of M. japonicus represented by 2129 metabolite features. M. japonicus de novo transcriptome assembly showed 96.9% transcriptome completeness, representing 226,250 active transcripts across seven tissues. We identified specialized metabolites biosynthesis in a tissue-specific manner, with a strong correlation between transcripts expression and metabolite accumulations in M. japonicus. The correlation- and network-based integration of metabolome and transcriptome datasets identified candidate genes involved in the biosynthesis of key specialized metabolites of M. japonicus. We further used phylogenetic analysis to identify 13 C-glycosyltransferases and 11 methyltransferases coding candidate genes involved in the biosynthesis of medicinally important bergenin. This study provides comprehensive, high-quality multi-omics resources to further investigate biological properties of specialized metabolites biosynthesis in M. japonicus.
APA, Harvard, Vancouver, ISO, and other styles
3

Chen, Si, Jun Lin, Huihui Liu, Zhihong Gong, Xiaxia Wang, Meihong Li, Asaph Aharoni, Zhenbiao Yang, and Xiaomin Yu. "Insights into Tissue-specific Specialized Metabolism in Tieguanyin Tea Cultivar by Untargeted Metabolomics." Molecules 23, no. 7 (July 21, 2018): 1817. http://dx.doi.org/10.3390/molecules23071817.

Full text
Abstract:
Tea plants produce extremely diverse and abundant specialized metabolites, the types and levels of which are developmentally and environmentally regulated. However, little is known about how developmental cues affect the synthesis of many of these molecules. In this study, we conducted a comparative profiling of specialized metabolites from six different tissues in a premium oolong tea cultivar, Tieguanyin, which is gaining worldwide popularity due to its uniquely rich flavors and health benefits. UPLC-QTOF MS combined with multivariate analyses tentatively identified 68 metabolites belonging to 11 metabolite classes, which exhibited sharp variations among tissues. Several metabolite classes, such as flavonoids, alkaloids, and hydroxycinnamic acid amides were detected predominantly in certain plant tissues. In particular, tricoumaroyl spermidine and dicoumaroyl putrescine were discovered as unique tea flower metabolites. This study offers novel insights into tissue-specific specialized metabolism in Tieguanyin, which provides a good reference point to explore gene-metabolite relationships in this cultivar.
APA, Harvard, Vancouver, ISO, and other styles
4

Nguyen, Don D., Veronika Saharuka, Vitaly Kovalev, Lachlan Stuart, Massimo Del Prete, Kinga Lubowiecka, René De Mot, Vittorio Venturi, and Theodore Alexandrov. "Facilitating Imaging Mass Spectrometry of Microbial Specialized Metabolites with METASPACE." Metabolites 11, no. 8 (July 23, 2021): 477. http://dx.doi.org/10.3390/metabo11080477.

Full text
Abstract:
Metabolite annotation from imaging mass spectrometry (imaging MS) data is a difficult undertaking that is extremely resource intensive. Here, we adapted METASPACE, cloud software for imaging MS metabolite annotation and data interpretation, to quickly annotate microbial specialized metabolites from high-resolution and high-mass accuracy imaging MS data. Compared with manual ion image and MS1 annotation, METASPACE is faster and, with the appropriate database, more accurate. We applied it to data from microbial colonies grown on agar containing 10 diverse bacterial species and showed that METASPACE was able to annotate 53 ions corresponding to 32 different microbial metabolites. This demonstrates METASPACE to be a useful tool to annotate the chemistry and metabolic exchange factors found in microbial interactions, thereby elucidating the functions of these molecules.
APA, Harvard, Vancouver, ISO, and other styles
5

Clark, Chase M., Maria S. Costa, Laura M. Sanchez, and Brian T. Murphy. "Coupling MALDI-TOF mass spectrometry protein and specialized metabolite analyses to rapidly discriminate bacterial function." Proceedings of the National Academy of Sciences 115, no. 19 (April 23, 2018): 4981–86. http://dx.doi.org/10.1073/pnas.1801247115.

Full text
Abstract:
For decades, researchers have lacked the ability to rapidly correlate microbial identity with bacterial metabolism. Since specialized metabolites are critical to bacterial function and survival in the environment, we designed a data acquisition and bioinformatics technique (IDBac) that utilizes in situ matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) to analyze protein and specialized metabolite spectra recorded from single bacterial colonies picked from agar plates. We demonstrated the power of our approach by discriminating between twoBacillus subtilisstrains in <30 min solely on the basis of their differential ability to produce cyclic peptide antibiotics surfactin and plipastatin, caused by a single frameshift mutation. Next, we used IDBac to detect subtle intraspecies differences in the production of metal scavenging acyl-desferrioxamines in a group of eight freshwaterMicromonosporaisolates that share >99% sequence similarity in the 16S rRNA gene. Finally, we used IDBac to simultaneously extract protein and specialized metabolite MS profiles from unidentified Lake Michigan sponge-associated bacteria isolated from an agar plate. In just 3 h, we created hierarchical protein MS groupings of 11 environmental isolates (10 MS replicates each, for a total of 110 spectra) that accurately mirrored phylogenetic groupings. We further distinguished isolates within these groupings, which share nearly identical 16S rRNA gene sequence identity, based on interspecies and intraspecies differences in specialized metabolite production. IDBac is an attempt to couple in situ MS analyses of protein content and specialized metabolite production to allow for facile discrimination of closely related bacterial colonies.
APA, Harvard, Vancouver, ISO, and other styles
6

Nicault, Matthieu, Abdoul-Razak Tidjani, Anthony Gauthier, Stéphane Dumarcay, Eric Gelhaye, Cyril Bontemps, and Pierre Leblond. "Mining the Biosynthetic Potential for Specialized Metabolism of a Streptomyces Soil Community." Antibiotics 9, no. 5 (May 23, 2020): 271. http://dx.doi.org/10.3390/antibiotics9050271.

Full text
Abstract:
The diversity and distribution of specialized metabolite gene clusters within a community of bacteria living in the same soil habitat are poorly documented. Here we analyzed the genomes of 8 Streptomyces isolated at micro-scale from a forest soil that belong to the same species or to different species. The results reveal high levels of diversity, with a total of 261 biosynthesis gene clusters (BGCs) encoding metabolites such as terpenes, polyketides (PKs), non-ribosomal peptides (NRPs) and ribosomally synthesized and post-translationally modified peptides (RiPPs) with potential bioactivities. A significant part of these BGCs (n = 53) were unique to only one strain when only 5 were common to all strains. The metabolites belong to very diverse chemical families and revealed that a large diversity of metabolites can potentially be produced in the community. Although that analysis of the global metabolome using GC-MS revealed that most of the metabolites were shared between the strains, they exhibited a specific metabolic pattern. We also observed that the presence of these accessory pathways might result from frequent loss and gain of genes (horizontal transfer), showing that the potential of metabolite production is a dynamic phenomenon in the community. Sampling Streptomyces at the community level constitutes a good frame to discover new biosynthetic pathways and it appears as a promising reservoir for the discovery of new bioactive compounds.
APA, Harvard, Vancouver, ISO, and other styles
7

Nagel, Raimund. "Pyrethrin Biosynthesis: From a Phytohormone to Specialized Metabolite." Plant Physiology 181, no. 3 (November 2019): 836–37. http://dx.doi.org/10.1104/pp.19.01210.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Du, Yi-Ling, Melanie A. Higgins, Guiyun Zhao, and Katherine S. Ryan. "Convergent biosynthetic transformations to a bacterial specialized metabolite." Nature Chemical Biology 15, no. 11 (August 12, 2019): 1043–48. http://dx.doi.org/10.1038/s41589-019-0331-5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Shaikh, Arshad Ali, Louis-Felix Nothias, Santosh K. Srivastava, Pieter C. Dorrestein, and Kapil Tahlan. "Specialized Metabolites from Ribosome Engineered Strains of Streptomyces clavuligerus." Metabolites 11, no. 4 (April 13, 2021): 239. http://dx.doi.org/10.3390/metabo11040239.

Full text
Abstract:
Bacterial specialized metabolites are of immense importance because of their medicinal, industrial, and agricultural applications. Streptomyces clavuligerus is a known producer of such compounds; however, much of its metabolic potential remains unknown, as many associated biosynthetic gene clusters are silent or expressed at low levels. The overexpression of ribosome recycling factor (frr) and ribosome engineering (induced rpsL mutations) in other Streptomyces spp. has been reported to increase the production of known specialized metabolites. Therefore, we used an overexpression strategy in combination with untargeted metabolomics, molecular networking, and in silico analysis to annotate 28 metabolites in the current study, which have not been reported previously in S. clavuligerus. Many of the newly described metabolites are commonly found in plants, further alluding to the ability of S. clavuligerus to produce such compounds under specific conditions. In addition, the manipulation of frr and rpsL led to different metabolite production profiles in most cases. Known and putative gene clusters associated with the production of the observed compounds are also discussed. This work suggests that the combination of traditional strain engineering and recently developed metabolomics technologies together can provide rapid and cost-effective strategies to further speed up the discovery of novel natural products.
APA, Harvard, Vancouver, ISO, and other styles
10

Vicente, Cláudia, Annabelle Thibessard, Jean-Noël Lorenzi, Mabrouka Benhadj, Laurence Hôtel, Djamila Gacemi-Kirane, Olivier Lespinet, Pierre Leblond, and Bertrand Aigle. "Comparative Genomics among Closely Related Streptomyces Strains Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity." Antibiotics 7, no. 4 (October 2, 2018): 86. http://dx.doi.org/10.3390/antibiotics7040086.

Full text
Abstract:
Specialized metabolites are of great interest due to their possible industrial and clinical applications. The increasing number of antimicrobial resistant infectious agents is a major health threat and therefore, the discovery of chemical diversity and new antimicrobials is crucial. Extensive genomic data from Streptomyces spp. confirm their production potential and great importance. Genome sequencing of the same species strains indicates that specialized metabolite biosynthetic gene cluster (SMBGC) diversity is not exhausted, and instead, a pool of novel specialized metabolites still exists. Here, we analyze the genome sequence data from six phylogenetically close Streptomyces strains. The results reveal that the closer strains are phylogenetically, the number of shared gene clusters is higher. Eight specialized metabolites comprise the core metabolome, although some strains have only six core gene clusters. The number of conserved gene clusters common between the isolated strains and their closest phylogenetic counterparts varies from nine to 23 SMBGCs. However, the analysis of these phylogenetic relationships is not affected by the acquisition of gene clusters, probably by horizontal gene transfer events, as each strain also harbors strain-specific SMBGCs. Between one and 15 strain-specific gene clusters were identified, of which up to six gene clusters in a single strain are unknown and have no identifiable orthologs in other species, attesting to the existing SMBGC novelty at the strain level.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Specialized metabolite"

1

Fallon, Timothy Robert. "The evolution and specialized metabolism of beetle bioluminescence." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122840.

Full text
Abstract:
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019
Cataloged from PDF version of thesis.
Includes bibliographical references.
Fireflies (Lampyridae) and certain other families of beetles including the American railroad worms (Phengodidae), Asian starworms (Rhagophthalmidae), and American click-beetles (Elateridae), produce light in a process known as bioluminescence. The bioluminescent systems of beetles, natively used for the purposes of mating communication and/or an aposematic warning signal, are now well understood and have been widely applied in biotechnology and biomedical research. There have been considerable advancements in the engineering of the luciferin substrate, and the luciferase enzyme, for beneficial characteristics such as altered emission wavelength, improved thermostability, and improved catalytic parameters, but despite this substantial effort focused on the biotechnological applications of beetle bioluminescence, major questions remain regarding its natural biochemistry and evolutionary origins.
Four major questions that were unanswered at the beginning of this PhD study were: (1) Do fireflies possess a storage form of their luciferin? (2) What is the evolutionary relationship of bioluminescence amongst the bioluminescent beetles families, and has this trait independently evolved multiple times? (3) How is firefly luciferin biosynthesized? And (4) Are there accessory genes from the bioluminescent beetles which act in bioluminescent metabolism, and might these genes be useful for biotechnological applications? Here I describe the discovery and characterization of the presumed storage form of luciferin in fireflies, sulfoluciferin, and the enzyme which produces it, luciferin-sulfotransferase.
Furthermore, I describe the sequencing, assembly, and characterization of the genome of the North American "Big Dipper" firefly Photinus pyralis, along with the Japanese "heike" firefly Aquatica lateralis genome, and the genome of the Puerto Rican bioluminescent click beetle or "cucubano" Ignelater luminosus. Genomic comparisons amongst these three species support the hypothesis that firefly and click beetle luciferase evolved independently, suggesting an independent evolutionary origin of the bioluminescent systems between these fireflies and click beetles. I also describe stable isotope tracing experiments in live fireflies, establishing that adult and larval fireflies likely do not de novo biosynthesize firefly luciferin, and may instead rely on a "recycling" pathway to re-synthesize luciferin from the luminescence product oxyluciferin. Lastly, I discuss the future directions resulting from this thesis, and the yet unanswered questions.
by Timothy Robert Fallon.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Biological Engineering
APA, Harvard, Vancouver, ISO, and other styles
2

Xie, Zhengzhi. "Investigation of Plant Specialized Metabolism (Secondary Metabolism) Using Metabolomic and Proteomic Approaches." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/195218.

Full text
Abstract:
Specialized metabolism (secondary metabolism) in glandular trichomes of sweet basil (Ocimum basilicum L.) and accumulation of specialized metabolites (secondary metabolites) in rhizomes of turmeric (Curcuma longa L.) was investigated using proteomic and metabolomic approaches, respectively. In an effort to further clarify the regulation of metabolism in the glandular trichomes of sweet basil, we utilized a proteomics-based approach that applied MudPIT (multidimensional protein identification technology) and GeLC-MS/MS (gel enhanced LC-MS/MS) to protein samples from isolated trichomes of four different basil lines: MC, SW, SD, and EMX-1. Phosphorylation, ubiquitination and methylation of proteins in these samples were detected using X!tandem. Significant differences in distribution of the 755 non-redundant protein entries demonstrated that the proteomes of the glandular trichomes of the four basil lines were quite distinct. Correspondence between proteomic, EST, and metabolic profiling data demonstrated that both transcriptional regulation and post-transcriptional regulation contribute to the chemical diversity. One very interesting finding was that precursors for different classes of terpenoids, including mono- and sesquiterpenoids, appear to be almost exclusively supplied by the MEP (2-C-methyl-D-erythritol 4- phosphate) pathway, but not the mevolonate pathway, in basil glandular trichomes. Our results suggest that carbon flow can be readily redirected between the phenylpropanoid and terpenoid pathways in this specific cell type. To investigate the impact of genetic, developmental and environmental factors on the accumulation of phytochemicals in rhizomes of turmeric, we performed metabolomic analysis in a 2x2x4 full factorial design experiment using GC-MS, LC-MS, and LC-PDA. Our results showed that growth stage had the largest effect on levels of the three major curcuminoids. Co-regulated metabolite modules were detected, which provided valuable information for identification of phytochemicals and investigation of their biosynthesis. Based on LC-MS/MS data, 4 new diarylheptanoids were tentatively identified in turmeric rhizomes using Tandem-MSASC, a home-made software tool that automatically recognizes spectra of unknown compounds using three approaches. Based on our metabolomic results, we proposed two new strategies, “metabolomics-guided discovery” and “correlation bioassay”, to identify bioactive constituents from plant extracts based on information provided by metabolomic investigation.
APA, Harvard, Vancouver, ISO, and other styles
3

Casas, Maria I. "BIOCHEMICAL AND GENETIC CHARACTERIZATION OF SPECIALIZED FLAVONOID METABOLISM IN MAIZE." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1431071650.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Razmilic, Neira Valeria Isabel. "Metabolism analysis of streptomyces leeuwenhoekii C34 with a genome scale model and identification of Biosynthetic genes of specialized metabolites by genome mining." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/144111.

Full text
Abstract:
Doctor en Ciencias de la Ingeniería, Mención Ingeniería Química y Biotecnología
Streptomyces leeuwenhoekii C34 es una nueva cepa que fue aislada desde la laguna Chaxa ubicada en el Desierto de Atacama, Chile. Esta cepa produce metabolitos especializados con actividad contra Staph. aureus resistente a meticilina (MRSA): chaxamicinas y chaxalactinas. La secuencia genómica de S. leeuwenhoekii C34 se obtuvo mediante las tecnologías de Illumina Miseq y PACbio RS II SMRT. El genoma se utilizó para identificar clústers de genes biosintéticos (BGCs) que codifican para metabolitos especializados a través de minería de genomas, y para desarrollar un modelo a escala genómica (GSM) para estudiar las rutas de biosíntesis de producción de metabolitos especializados. Se encontraron 34 BGCs en el genoma de S. leeuwenhoekii C34, más un BGC ubicado en el plásmido pSLE2. Se encontró tres BGCs para lazo-péptidos. Específicamente, se identificó el producto del BGC del lazo-péptido 3 en el sobrenadante de S. leeuwenhoekii C34 cultivado en medio TSB/YEME y se expresó exitosamente en el huésped heterólogo S. coelicolor M1152. Se confirmó que este lazo-péptido era el mismo que la chaxapeptina, recientemente descrita para S. leeuwenhoekii C58. Por otra parte, se identificó un BGC de 64 kb (locus 1083651 a 1147687) que codifica para un híbrido trans-AT PKS/NRPS. Es probable que el producto de este BGC sea un compuesto halogenado debido a la presencia de un gen, sle09470, que codifica para una enzima cloradora. Para estudiar este clúster de genes, se desarrollaron diferentes cepas derivadas de S. leeuwenhoekii. También, el BGC se clonó en huéspedes heterólogos: S. coelicolor M1152, M1154 and S. albus. A través de análisis de HPLC MS/MS y comparación de perfiles de metabolitos, se identificó un grupo de compuestos con patrón clorado, sin embargo se descartaron como posibles productos del BGC ya que además de encontrarse en las cepas de S. leeuwenhoekii también se encontraron en muestras de S. coelicolor M1152. Por otra parte, se detecto un metabolito con una señal de m/z 611.53 [M + H]+ solamente en las muestras de S. leeuwenhoekii M1614 ( chaxamycin BGC) y M1619 ( chaxamycin BGC; sle09560). Se requieren msá estudios para confirmar si los metabolitos expresados diferencialmente corresponden a un producto del híbrido transAT-PKS/NRPS BGC. Para construir el GSM de S. leeuwenhoekii C34 se desarrolló una interfaz basada en python, que permite: buscar genes de Streptomyces asociados a reacciones en la base de datos KEGG, realizar BLAST local contra S. leeuwenhoekii C34, comparar los dominios de proteínas, descargar información de los metabolitos, construir el GSM y realizar simulaciones usando COBRApy. Las rutas biosintéticas de chaxamicinas, chaxalactinas, desferrioxaminas, ectoina y el producto del híbrido transAT-PKS/NRPS BGC (híbrido PK-NP) se incluyeron en el modelo. El modelo, iVR1007, consiste de 1722 reacciones, 1463 metabolitos y 1007 genes, y se validó usando información experimental de crecimiento en diferentes fuentes de carbono, nitrógeno y fósforo, mostrando un 83.7 % de precisión. El modelo se usó para encontrar deleción y sobre-expresión de genes no intuitivas que predicen un aumento en la producción de precursores de chaxamicinas, chaxalactinas e híbrido PK-NP. Las modificaciones predichas podrán ser usadas para realizar ingeniería metabólica de S. leeuwenhoekii C34 para incrementar la producción de metabolitos especializados.
APA, Harvard, Vancouver, ISO, and other styles
5

Barthélémy, Morgane. "Etude de la diversité chimique et biologique d’endophytes de palmiers." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS563.

Full text
Abstract:
Dans cette étude, le palmier Astrocaryum sciophilum a été choisi comme modèle pour l'étude de ses endophytes foliaires. Du fait de sa longévité, nous avons cherché à mettre en évidence une communauté compétitive d’endophytes en fonction de l’âge de ses feuilles. Afin d’évaluer si les métabolites produits par ces endophytes pourraient être utilisés en santé humaine, les extraits de chaque endophyte ont été testés contre Staphylococcus aureus résistant à la méticilline (SARM) ainsi que pour leur activité quorum quenching (QQ). En parallèle, afin d’identifier un rôle écologique de protection de la plante par ces endophytes, des co-cultures ont été réalisées avec le phytopathogène Fusarium oxysporum. Plusieurs extraits de souches ont été sélectionnés afin d’isoler et d’identifier le ou les métabolites responsables des activités biologiques observées. Différents outils analytiques ont permis de guider le processus d’isolement (LC-MS/MS, réseaux moléculaires et imagerie par spectrométrie de masse). L’étude de la communauté d’endophytes isolée des feuilles âgées n’a pas mis en évidence un arsenal chimique plus compétitif. Toutefois, deux souches bactériennes du genre Luteibacter sp. ont montré un extrait actif sur SARM et de nombreux extraits de bactéries présentent une activité QQ. Par la suite, le métabolome secondaire du genre Colletotrichum a été étudié à l’aide des réseaux moléculaires et un champignon de la famille des Xylariaceae a été étudié pour son activité contre F. oxysporum. Dans le cadre de cette thèse, sept souches endophytes ont été étudiées chimiquement permettant l’isolement et l’identification de 42 molécules dont dix sont nouvelles
The palm Astrocaryum sciophilum is the host plant model chosen in this work. Indeed, due to the longevity of its leaves, we expected to highlight a competitive community of endophytes within the oldest leaves. Thus, 197 endophytes have been isolated and identified from different leaves of six palm specimens. In order to evaluate whether the compounds produced by these microorganisms could be used for the treatment of human disease, the ethyl acetate extracts of each endophyte were tested against methicillin-resistant Staphylococcus aureus (MRSA) as well as for a quorum quenching (QQ) activity. Simultaneously, co-culture were carried with the fungi Fusarium oxysporum in order to highlight endophytes providing plant protection against phytopathogens. We selected extracts in order to isolate and identify the bioactive metabolites. Various analytical tools have been used to improve the isolation process (LC-MS/MS, molecular networking or MS imaging).The study of the endophytic community isolated from older leaves did not show a more competitive chemical arsenal. However, two Luteibacter strains exhibited an ethyl acetate extract active against MRSA and several bacteria provide quorum quenching extracts. The metabolome of Colletotrichum genus was studied using molecular networking and a fungus from the Xylariaceae family was studied for its capacity to inhibit F. oxysporum’s growth. In our study, seven endophyte strains were chemically investigated leading to the isolation and identification of 42 molecules whose ten are new
APA, Harvard, Vancouver, ISO, and other styles
6

Mütze, Ulrike, Alena Gerlinde Thiele, Christoph Baerwald, Uta Ceglarek, Wieland Kiess, and Skadi Beblo. "Ten years of specialized adult care for phenylketonuria." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205208.

Full text
Abstract:
Background: Specialized adult care of phenylketonuria (PKU) patients is of increasing importance. Adult outpatient clinics for inherited errors of metabolism can help to achieve this task, but experience is limited. Ten years after establishment of a coordinated transition process and specialised adult care for inherited metabolic diseases, adult PKU care was evaluated with respect to metabolic control, therapy satisfaction, life satisfaction, sociodemographic data, economical welfare as well as pregnancy outcome. Methods: All PKU patients transferred from paediatric to adult care between 2005 and 2015 were identified. A retrospective data analysis and a cross-sectional survey in a sub-cohort of 30 patients including a questionnaire for assessing quality of life (FLZm) were performed as a single-centre investigation at the metabolic department of the University Hospital Leipzig, Germany. For statistical analysis, Mann-Whitney-U-test, t-test for independent samples, ANOVA and chi square test were used as appropriate. Results: 96 PKU patients (56 females/40 males; median age 32 years, range 18–62) were included. In the last 3-year period, 81 % of the transferred patients still kept contact to the adult care centre. Metabolic control was stable over the evaluation period and dried blood phenylalanine concentrations mostly remained within the therapeutic range (median 673.0 μmol/l, range 213.0–1381.1). Sociodemographic data, economical welfare and life satisfaction data were comparable to data from the general population. However, differences could be revealed when splitting the cohort according to time of diagnosis and to management during childhood. 83 % of the PKU adults were satisfied with the transition process and current adult care. 25 completed pregnancies were supervised; three newborns, born after unplanned pregnancy, showed characteristic symptoms of maternal PKU syndrome. Conclusions: Continuous care for adult PKU patients in a specialized outpatient clinic is successful, leading to good to satisfactory metabolic control and social outcomes. Uninterrupted good metabolic treatment throughout childhood and adolescence positively influences educational, professional and economic success in later life. Further effort in specialized paediatric and adult metabolic care is needed to prevent loss of follow-up and to support the recommended life-long treatment and/or care.
APA, Harvard, Vancouver, ISO, and other styles
7

Aubry, Céline. "Towards combinatorial biosynthesis of pyrrolamide antibiotics in Streptomyces." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS245.

Full text
Abstract:
Depuis plus de 80 ans, le métabolisme spécialisé nous fournit de nombreuses molécules utilisées en médecine, en particulier comme anti-infectieux. Aujourd’hui, avec l’augmentation mondiale de la résistance aux antimicrobiens, de nouveaux antibiotiques sont indispensables. Une des réponses à cette pénurie grave pourrait provenir de la biologie synthétique. Dans le domaine du métabolisme spécialisé, la biologie synthétique est utilisée en particulier pour la biosynthèse de métabolites non naturels. Parmi les métabolites spécialisés, les peptides non ribosomiques constituent une cible attrayante, car ils nous ont déjà fourni des molécules à haute valeur clinique (ex. les antibiotiques vancomycine et daptomycine). De plus, la plupart sont synthétisés par des enzymes multimodulaires appelées synthétases de peptides non ribosomiques (NRPS), et sont diversifiés davantage par des enzymes de décoration. Ainsi, ces voies de biosynthèse se prêtent particulièrement à la biosynthèse combinatoire, consistant à combiner des gènes de biosynthèse provenant de divers groupes de gènes ou, dans le cas des NRPS, à combiner des modules ou domaines pour créer de nouvelles enzymes. Cependant, si plusieurs études ont établi la faisabilité de telles approches, de nombreux obstacles subsistent avant que les approches combinatoires de biosynthèse soient totalement efficaces pour la synthèse de nouveaux métabolites. Les travaux présentés ici s’inscrivent dans le cadre d’un projet visant à comprendre les facteurs limitant les approches de biosynthèse combinatoire basées sur les NRPS, en utilisant une approche de biologie synthétique. Nous avons choisi de travailler avec les NRPS responsables de la biosynthèse des pyrrolamides. En effet, ces NRPS sont constitués uniquement de modules et de domaines autonomes, et donc particulièrement adaptés aux manipulations génétiques et biochimiques. La caractérisation du groupe de gènes de biosynthèse du pyrrolamide anthelvencine constitue la première partie de cette thèse et nous a fourni de nouveaux gènes pour notre étude. La deuxième partie a consisté à construire de vecteurs intégratifs modulaires, outils essentiels pour la construction et l’assemblage de cassettes génétiques. La dernière partie présente la reconstruction du groupe de gènes du pyrrolamide congocidine, basée sur la construction et l’assemblage de cassettes de gènes synthétiques. Dans l’ensemble, ces travaux ouvrent la voie à de futures expériences de biosynthèse combinatoire, expériences qui devraient contribuer à une meilleure compréhension du fonctionnement précis des NRPS
For more than 80 years, specialized metabolism has provided us with many molecules used in medicine, especially as anti-infectives. Yet today, with the rise of antimicrobial resistance worldwide, new antibiotics are crucially needed. One of the answers to this serious shortage could arise from synthetic biology. In the field of specialized metabolism, synthetic biology is used in particular to biosynthesize unnatural metabolites. Among specialized metabolites, non-ribosomal peptides constitute an attractive target as they have already provided us with clinically valuable molecules (e.g. the vancomycin and daptomycin antibiotics). In addition, most are synthesized by multimodular enzymes called non-ribosomal peptide synthetases (NRPS) and further diversified by tailoring enzymes. Thus, such biosynthetic pathways are particularly amenable to combinatorial biosynthesis, which consists in combining biosynthetic genes coming from various gene clusters or, in the case of NRPSs, combining modules or domains to create a new enzyme. Yet, if several studies have established the feasibility of such approaches, many obstacles remain before combinatorial biosynthesis approaches are fully effective for the synthesis of new metabolites. The work presented here is part of a project aiming at understanding the limiting factors impeding NRPS-based combinatorial biosynthesis approaches, using a synthetic biology approach. We chose to work with the NRPSs involved in the biosynthesis of pyrrolamides. Indeed, these NRPS are solely constituted of stand-alone modules and domains, and thus, particularly amenable to genetic and biochemical manipulations. The characterization of the biosynthetic gene cluster of the pyrrolamide anthelvencin constitutes the first part of this thesis, and provided us with new genes for our study. The second part involved the construction of modular integrative vectors, essential tools for the construction and assembly of gene cassettes. The final part presents the successful refactoring of the congocidine pyrrolamide gene cluster, based on the construction and assembly of synthetic gene cassettes. Altogether, this work paves the way for future combinatorial biosynthesis experiments that should help deciphering the detailed functioning of NRPSs
APA, Harvard, Vancouver, ISO, and other styles
8

Erland, Lauren Alexandra Elizabeth. "Enhancement of specialized metabolism, regeneration efficiency and biological activity in lavandin (Lavandula x intermedia cv 'Grosso')." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52707.

Full text
Abstract:
This study aimed to improve essential oil composition by modifying terpene production in Lavandula x intermedia cv Grosso via mutagenesis to more closely resemble the oil of the commercially valuable essential oil from L. angustifolia or the medicinally active essential oil from L. latifolia. Additionally this study aimed to identify genes that control essential oil production in lavenders, and to determine the effect of essential oil composition on biological activity, specifically insecticidal and insect repellent properties. This study resulted in an improved method for the efficient regeneration of Grosso lavender, and applied this method to generate ten unique mutants. The transcriptomes of some mutants were sequenced, and thirty seven differentially expressed transcripts were identified as being involved in the biosynthesis and production of essential oil terpenes. The transcript expression results were confirmed by real-time quantitative polymerase chain reaction analysis. The lavender essential oil showing greatest biological activity against an invasive pest, spotted wing drosophila, was identified as Lavandula latifolia cv Medikus and the active constituents were identified through fumigation and spray toxicity assays as the monoterpenes 1,8-cineole and linalool. These oils showed strong fumigation and contact toxicity. In all, this thesis presents the generation, screening and analysis of unique L. x intermedia essential oil mutants, which represent both potential new commercial cultivars and model organisms for the investigation of the regulation and biosynthesis of essential oil terpenes.
Irving K. Barber School of Arts and Sciences (Okanagan)
Biology, Department of (Okanagan)
Graduate
APA, Harvard, Vancouver, ISO, and other styles
9

Muchlinski, Andrew Joseph. "Identification, Characterization, and Functional Analysis of Terpenoid Specialized Metabolism in Switchgrass (Panicum virgatum) and Carrot (Daucus carota)." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/102778.

Full text
Abstract:
Plants produce a large number of specialized or secondary compounds that aid in their reproduction and protection against biotic and abiotic stress. In this work I investigated the metabolism and function of terpenes, the largest class of specialized metabolites, in switchgrass and carrot. Switchgrass (Panicum virgatum L.), a perennial C4 grass of the Tallgrass Prairie, represents an important species in natural and anthropogenic grasslands of North America. Its natural resilience to abiotic and biotic stress has made switchgrass a preferred bioenergy crop. I have investigated the metabolism of terpenes in switchgrass leaves and roots in response to herbivory or defense hormone treatments and the application of drought. With a focus on volatile terpene metabolites, I functionally characterized over thirty genes (terpene synthases, TPSs), of which one third could be correlated with the production and release of volatile monoterpenes and sesquiterpenes that likely function in direct chemical defense or in the attraction of insect predators or parasitoids. Drought stress application caused switchgrass roots to accumulate a larger amount of oxygenated terpenes and presumably non-volatile terpenes, the function of which in direct or indirect drought stress protection requires further investigation. I also examined the metabolic dynamics and role of the monoterpene borneol, which accumulates at high concentrations in the roots of switchgrass and to a lower extent in the roots of the close relative Setaria viridis, in root microbe interactions. Although we demonstrated a successful RNAi based knock down of the borneol terpene synthase TPS04, we found no immediate evidence that borneol significantly modifies bacterial communities in the root. Further studies on Setaria and equivalent RNAi lines in switchgrass will provide more detailed and needed insight to decipher the role of monoterpene accumulation in grasses interactions with mutualists, pathogens, and pests. In an applied project, I investigated terpene specialized metabolism in carrot (Daucus carota L.) to identify genetic determinants of carrot aroma and flavor. To determine central enzymes which contribute to the terpene component of carrot volatile blends, we first analyzed tissue specific expression patterns of carrot terpene synthase genes (TPS) in the genomic model carrot (cv. DH1) and in roots of four aromatically unique colored carrot genotypes (orange-4943B, red-R6637, yellow-Y9244A and purple-P7262). We selected nineteen key biosynthetic enzymes involved in terpene formation and compared in vitro products from recombinant proteins with native volatile profiles obtained from DH1 and colored carrot genotypes. We biochemically characterized several highly expressed TPSs with direct correlations to major compounds of carrot flavor and aroma including germacrene-D (DcTPS11), (DcTPS30) and -terpinolene (DcTPS03). Random forest analysis of colored carrot volatiles revealed that nine terpene compounds are sufficient for distinguishing the flavor and aroma of raw colored carrots. Interestingly, accumulation of specific terpene compounds rather than chemical diversity is responsible for differences in sensory quality traits in colored genotypes. As accumulations of specific terpene compounds can contribute to the undesired flavor in carrot, our report provides a detailed roadmap for future breeding efforts to enhance carrot flavor and aroma.
Doctor of Philosophy
APA, Harvard, Vancouver, ISO, and other styles
10

Jorge, Letícia Galhardo. "Desempenho fotossintético, perfil e atividade do óleo essencial de Xylopia aromatica (Lam.) Mart. nas fases vegetativa e reprodutiva no cerrado paulista." Botucatu, 2020. http://hdl.handle.net/11449/192182.

Full text
Abstract:
Orientador: Carmen Silvia Fernandes Boaro
Resumo: Espécies vegetais são capazes de produzir diversidade de substâncias, que desempenham funções importantes para sua sobrevivência e adaptação ao ecossistema. O metabolismo primário, é essencial para o crescimento, desenvolvimento, maturação e reprodução de qualquer espécie. O metabolismo especializado, dependente do primário, é responsável por originar o óleo essencial, que são misturas de metabólitos especializados voláteis, representados principalmente por monoterpenos e sesquiterpenos. Cada espécie vegetal produz um óleo essencial de composição característica específica, podendo ser influenciado por fatores bióticos e abióticos. A fenologia pode influenciar processos bioquímicos e rotas metabólicas capazes de modificar a formação de substâncias biologicamente ativas, alterando diretamente o conteúdo e a qualidade dos óleos essenciais. Sendo assim, o objetivo deste trabalho foi avaliar se as fases fenológicas, vegetativa e reprodutiva modificam o desempenho fotossintético e o perfil do óleo essencial de Xylopia aromatica (Lam.) Mart., influenciando sua atividade biológica na defesa antioxidante e ação antifúngica. As variáveis, fluorescência da clorofila a, trocas gasosas, carboidratos, atividade enzimática e peroxidação lipídica, potencial água, conteúdo relativo de água das folhas, extração, rendimento, caracterização química e atividade antifúngica do óleo essencial de Xylopia aromatica foram avaliadas em 24 plantas, 12 no estádio vegetativo e 12 no reprodutivo, coletadas... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Research aimed at the knowledge of plant species allows the elaboration of projects that aim at the understanding of development, conservation of biodiversity and sustainable exploitation of natural resources. The primary metabolism, represented by photosynthesis and the specialized one, that synthesizes the essential oil, can be influenced by the environmental and phenological conditions, which can influence the chemical profile of the essential oil and the biological activity in the vegetal defense, including against fungi, bacteria and virus. Compounds from the specialized metabolism present biological activity and potential for the production of bactericides and fungicides. Therefore, it is necessary to know the stage of development of plant species in which the substances of interest, with economic potential, are more concentrated, thus orienting, if appropriate, the collection period, aiming at the conservation and sustainable use. There are scientific studies that reveal biological activity of essential oils, as observed for the genus Xylopia, but none of them relates the primary and specialized metabolism to the stage of development in which the species is found. In this way, the objective of this research was to evaluate if the phenological, vegetative and reproductive phases of Xylopia aromatica (Lam.) Mart. modify the photosynthetic performance and the profile of the essential oil, which may influence its biological activity in the antioxidant defense and antifunga... (Complete abstract click electronic access below)
Mestre
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Specialized metabolite"

1

Arimura, Gen-ichiro, and Massimo Maffei, eds. Plant Specialized Metabolism. Boca Raton : Taylor & Francis, 2017.: CRC Press, 2016. http://dx.doi.org/10.1201/9781315370453.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Moore, Bradley S. Marine Enzymes and Specialized Metabolism - Part A. Elsevier Science & Technology, 2018.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Marine Enzymes and Specialized Metabolism - Part A. Elsevier, 2018. http://dx.doi.org/10.1016/s0076-6879(18)x0006-8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Marine Enzymes and Specialized Metabolism - Part B. Elsevier, 2018. http://dx.doi.org/10.1016/s0076-6879(18)x0007-x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Moore, Bradley S. Marine Enzymes and Specialized Metabolism - Part B. Elsevier Science & Technology, 2018.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Plant Specialized Metabolism: Genomics, Biochemistry, and Biological Functions. Taylor & Francis Group, 2016.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Suzuki, Hideyuki, and Tomonobu Kusano. Polyamines: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer, 2015.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Hollak, Carla E. M., and Robin Lachmann, eds. Inherited Metabolic Disease in Adults. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.001.0001.

Full text
Abstract:
As clinical management of inherited metabolic diseases (IMDs) has improved, more patients affected by these conditions are surviving into adulthood. This trend, coupled with the widespread recognition that IMDs can present differently and for the first time during adulthood, makes the need for a working knowledge of these diseases more important than ever.Inherited Metabolic Disease in Adults offers an authoritative clinical guide to the adult manifestations of these challenging and myriad conditions. These include both the classic pediatric-onset conditions and a number of new diseases that can manifest at any age. It is the first book to give a clear and concise overview of how this group of conditions affects adult patients, a topic that will become a growing imperative for physicians across primary and specialized care.
APA, Harvard, Vancouver, ISO, and other styles
9

Shaffu, Shireen, and James Taylor. Normal function of the musculoskeletal system. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0263.

Full text
Abstract:
The musculoskeletal system consists of specialized connective tissue whose primary function is to allow locomotion. The tissues of the musculoskeletal system are bones, muscles, tendons, and ligaments. In particular, the bony skeleton also has the task of protecting vital internal organs, contains the bone marrow, and is an intrinsic part of the metabolic pathways involved in calcium homeostasis. Motion is allowed by specialized articulating structures, the joints.
APA, Harvard, Vancouver, ISO, and other styles
10

Ellison, Aaron M., and Lubomír Adamec. Introduction: what is a carnivorous plant? Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198779841.003.0001.

Full text
Abstract:
The approximately 800 species of carnivorous plant together provide a classic example of convergent evolution. The known carnivorous species and genera represent nine independent angiosperm lineages. They are united by a suite of five essential traits that together make up the ‘carnivorous syndrome:’ (1) capturing or trapping prey in specialized. usually attractive, traps; (2) killing the captured prey; (3) digesting the prey; (4) absorption of metabolites (nutrients) from the killed and digested prey; and (5) use of these metabolites for plant growth and development. Although many other ‘paracarnivorous’ plants have one or two of these traits, only plants that have all five of them that function in a coordinated way can be considered true carnivorous plants.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Specialized metabolite"

1

Kautsar, Satria A., Hernando G. Suarez Duran, and Marnix H. Medema. "Genomic Identification and Analysis of Specialized Metabolite Biosynthetic Gene Clusters in Plants Using PlantiSMASH." In Methods in Molecular Biology, 173–88. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7874-8_15.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Gonzalez, Orland, and Alberto Sanguino. "Specialized Metabolic Component Databases." In Encyclopedia of Systems Biology, 1963–66. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_1050.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Cluzet, S., Jean-Michel Mérillon, and Kishan Gopal Ramawat. "Specialized Metabolites and Plant Defence." In Progress in Biological Control, 45–80. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51034-3_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Tissier, Alain, Jörg Ziegler, and Thomas Vogt. "Specialized Plant Metabolites: Diversity and Biosynthesis." In Ecological Biochemistry, 14–37. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527686063.ch2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Falara, Vasiliki, and Eran Pichersky. "Plant Volatiles and Other Specialized Metabolites: Synthesis, Storage, Emission, and Function." In Signaling and Communication in Plants, 109–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-23047-9_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Moody, Matthew J., Stephanie E. Jones, David A. Crisante, and Marie A. Elliot. "Streptomyces Bacteria: Specialized Metabolism, Inter-species Interations and Non-coding RNAs." In Non-coding RNAs and Inter-kingdom Communication, 83–101. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-39496-1_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Shadkami, Farzad, and A. Daniel Jones. "Nontargeted Profiling of Specialized Metabolites ofDigitalis purpureawith a Focus on Cardiac Glycosides." In ACS Symposium Series, 185–205. Washington, DC: American Chemical Society, 2012. http://dx.doi.org/10.1021/bk-2012-1093.ch011.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

D’Amelia, Vincenzo, Alessandra Ruggiero, Valentina Tranchida-Lombardo, Antonietta Leone, Marina Tucci, and Teresa Docimo. "Biosynthesis of Salvia Specialized Metabolites and Biotechnological Approaches to Increase Their Production." In Salvia Biotechnology, 241–70. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-73900-7_7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Vázquez-Flota, Felipe A., and María de Lourdes Miranda-Ham. "Induction of Specialized Metabolism in In Vitro Cultures of Capsicum chinense Jacq." In Plant Cell Culture Protocols, 429–35. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8594-4_30.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Hartmann, Thomas, and Dietrich Ober. "Biosynthesis and Metabolism of Pyrrolizidine Alkaloids in Plants and Specialized Insect Herbivores." In Biosynthesis, 207–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/3-540-48146-x_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Specialized metabolite"

1

van der Hooft, Justin, Madeleine Ernst, Ricardo da Silva, Mingxun Wang, Kyo Bin Kang, Joe Wandy, Simon Rogers, Marnix Medema, and Pieter Dorrestein. "Integrated metabolome mining and annotation pipeline accelerates elucidation and prioritisation of specialised metabolites." In 3rd International Electronic Conference on Metabolomics. Basel, Switzerland: MDPI, 2018. http://dx.doi.org/10.3390/iecm-3-05843.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Tokhiriyon, Boisjoni, Valery Poznyakovsky, and Svetlana Andrievskikh. "Industrialization issues in the production of specialized products for complex body metabolism support." In Proceedings of the 2nd International Scientific conference on New Industrialization: Global, national, regional dimension (SICNI 2018). Paris, France: Atlantis Press, 2019. http://dx.doi.org/10.2991/sicni-18.2019.23.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Elrayess, Mohamed, Fatima Al-Khelaifi, Noha Yousri, and Omar Al-Bagha. "Genome-Wide Association study Identifies a Novel Association Between a Cardiovascular Gene Polymorphism and Superior Athletic Performance." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0111.

Full text
Abstract:
Research into the genetic predisposition to superior athletic performance has been a hindered by the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate the association of common single-nucleotide polymorphisms (SNPs) with endurance athlete status in a large cohort of elite European athletes using GWAS approach, followed by replication studies in Russian and Japanese elite athletes and functional validation using metabolomics analysis. Results: The association of 476,728 SNPs of Illumina DrugCore Gene chip and endurance athlete status was investigated in 796 European international-level athletes (645 males, 151 females) by comparing allelic frequencies between athletes specialized in sports with high (n=662) and low/moderate (n=134) aerobic component. Validation of results was performed by comparing the frequencies of the most significant SNPs between 242 and 168 elite Russian high and low/moderate aerobic athletes, respectively, and between 60 elite Japanese endurance athletes and 406 controls. A meta-analysis has identified rs1052373 (GG homozygotes) in Myosin Binding Protein (MYBPC3; implicated in cardiac hypertrophic myopathy) gene to be associated with endurance athlete status (P=1.43E-08, odd ratio 2.2). Homozygotes carriers of rs1052373 G allele in Russian athletes had significantly greater VO2max than carriers of the AA+AG (P = 0.005). Subsequent metabolomics analysis revealed several amino acids and lipids associated with rs1052373 G allele (1.82x10-05) including the testosterone precursor androstenediol (3beta, 17beta) disulfate. Conclusion: This is the first report of genome-wide significant SNP and related metabolites associated with elite athlete status. Further investigations of the functional relevance of the identified SNPs and metabolites in relation to enhanced athletic performance are warranted.
APA, Harvard, Vancouver, ISO, and other styles
4

Calvo-Aranda, Enrique, Fernando Manuel Sanchez-Aranda, Laura Cebrian, Maria Angeles Matias de la Mano, Elena Garcia-Lorenzo, and Maria Teresa Navio Marco. "AB0866 METABOLIC SYNDROME IN PATIENTS WITH GOUT ATTENDED IN A SPECIALIZED OUTPATIENT UNIT IN SPAIN. COMPARISON WITH GENERAL POPULATION AND CARDIOVASCULAR IMPLICATIONS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.5034.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Lai, Heather, Chin An Tan, and Yong Xu. "Dielectric Elastomer Energy Harvesting and its Application to Human Walking." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-65973.

Full text
Abstract:
Human walking requires sophisticated coordination of muscles, tendons, and ligaments working together to provide a constantly changing combination of force, stiffness and damping. In particular, the human knee joint acts as a variable damper, dissipating greater amounts of energy when the knee undergoes large rotational displacements during walking, running or hopping. Typically, this damping results from the dissipation, or loss, of metabolic energy. It has been proven to be possible however; to collect this otherwise wasted energy through the use of electromechanical transducers of several different types which convert mechanical energy to electrical energy. When properly controlled, this type of device not only provides desirable structural damping effects, but the energy generated can be stored for use in a wide range of applications. A novel approach to an energy harvesting knee joint damper is presented using a dielectric elastomer (DE) smart material based electromechanical transducer. Dielectric elastomers are extremely elastic materials with high electrical permittivity which operate based on electrostatic effects. By placing compliant electrodes on either side of a dielectric elastomer film, a specialized capacitor is created, which couples mechanical and electrical energy using induced electrostatic stresses. Dielectric elastomer energy harvesting devices not only have a high energy density, but the material properties are similar to that of human tissue, making it highly suitable for wearable applications. A theoretical framework for dielectric elastomer energy harvesting is presented along with a mapping of the active phases of the energy harvesting to the appropriate phases of the walking stride. Experimental results demonstrating the energy harvesting capability of a DE generator undergoing strains similar to those experienced during walking are provided for the purpose of verifying the theoretical results. The work presented here can be applied to devices for use in rehabilitation of patients with muscular dysfunction and transfemoral prosthesis as well as energy generation for able-bodied wearers.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Specialized metabolite' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography