Academic literature on the topic 'Spectrine'

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Journal articles on the topic "Spectrine"

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Goodman, Steven R., Daniel Johnson, Steven L. Youngentob, and David Kakhniashvili. "The Spectrinome: The Interactome of a Scaffold Protein Creating Nuclear and Cytoplasmic Connectivity and Function." Experimental Biology and Medicine 244, no. 15 (2019): 1273–302. http://dx.doi.org/10.1177/1535370219867269.

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We provide a review of Spectrin isoform function in the cytoplasm, the nucleus, the cell surface, and in intracellular signaling. We then discuss the importance of Spectrin’s E2/E3 chimeric ubiquitin conjugating and ligating activity in maintaining cellular homeostasis. Finally we present spectrin isoform subunit specific human diseases. We have created the Spectrinome, from the Human Proteome, Human Reactome and Human Atlas data and demonstrated how it can be a useful tool in visualizing and understanding spectrins myriad of cellular functions. Impact statement Spectrin was for the first 12 y
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Machnicka, Beata, Renata Grochowalska, Dżamila M. Bogusławska, and Aleksander F. Sikorski. "The role of spectrin in cell adhesion and cell–cell contact." Experimental Biology and Medicine 244, no. 15 (2019): 1303–12. http://dx.doi.org/10.1177/1535370219859003.

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Spectrins are proteins that are responsible for many aspects of cell function and adaptation to changing environments. Primarily the spectrin-based membrane skeleton maintains cell membrane integrity and its mechanical properties, together with the cytoskeletal network a support cell shape. The occurrence of a variety of spectrin isoforms in diverse cellular environments indicates that it is a multifunctional protein involved in numerous physiological pathways. Participation of spectrin in cell–cell and cell–extracellular matrix adhesion and formation of dynamic plasma membrane protrusions and
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Delaunay, J., R. Wilmotte, N. Alloisio та J. Maréchal. "L'allèle αLELY, un allèle tranquille, mais dangereux, du gène α-spectrine érythroïde". médecine/sciences 11, № 5 (1995): 752. http://dx.doi.org/10.4267/10608/2272.

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Franck, Paul Hubert Frans, Cobie Postma, Marjan Veuger, Pierre Wijermans та Frans A. Kuypers. "A Family with Hereditary Elliptocytosis: Variable Clinical Severity Caused by Three Mutations in the α-Spectrin Gene",. Blood 118, № 21 (2011): 3167. http://dx.doi.org/10.1182/blood.v118.21.3167.3167.

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Abstract Abstract 3167 Introduction The membrane of erythrocytes is composed of a bilayer of phospholipids and cholesterol. It is strengthened by a membraneskeleton consisting of the proteins spectrin, ankyrin, pallidin, band 3 and band 4.1. Hereditary elliptocytosis (HE) is caused by mutations in the spectrin protein, resulting in a typical elliptocytic shape. These cells have a decreased deformability and a shortened lifespan. Most mutations in HE are located in the head to head self association site of the α- and β dimers of spectrin. HE Patients with heterozygous mutations in α spectrin sh
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Moorthy, Suraj, Lihsia Chen та Vann Bennett. "Caenorhabditis elegans β-G Spectrin Is Dispensable for Establishment of Epithelial Polarity, but Essential for Muscular and Neuronal Function". Journal of Cell Biology 149, № 4 (2000): 915–30. http://dx.doi.org/10.1083/jcb.149.4.915.

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The Caenorhabditis elegans genome encodes one α spectrin subunit, a β spectrin subunit (β-G), and a β-H spectrin subunit. Our experiments show that the phenotype resulting from the loss of the C. elegans α spectrin is reproduced by tandem depletion of both β-G and β-H spectrins. We propose that α spectrin combines with the β-G and β-H subunits to form α/β-G and α/β-H heteromers that perform the entire repertoire of spectrin function in the nematode. The expression patterns of nematode β-G spectrin and vertebrate β spectrins exhibit three striking parallels including: (1) β spectrins are associ
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Howe, C. L., L. M. Sacramone, M. S. Mooseker, and J. S. Morrow. "Mechanisms of cytoskeletal regulation: modulation of membrane affinity in avian brush border and erythrocyte spectrins." Journal of Cell Biology 101, no. 4 (1985): 1379–85. http://dx.doi.org/10.1083/jcb.101.4.1379.

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The spectrins isolated from chicken erythrocytes and chicken intestinal brush border, TW260/240, share a common alpha subunit and a tissue-specific beta subunit. The ability of these related proteins to bind human erythrocyte inside out vesicles (IOVs) and human erythrocyte ankyrin in vitro have been quantitatively compared with human erythrocyte spectrin. Chicken erythrocyte spectrin binds human IOVs and human ankyrin with affinities nearly identical to that for human erythrocyte spectrin. TW260/240 does not significantly bind to either IOVs or ankyrin. These results demonstrate a remarkable
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Leto, T. L., D. Fortugno-Erikson, D. Barton, et al. "Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species." Molecular and Cellular Biology 8, no. 1 (1988): 1–9. http://dx.doi.org/10.1128/mcb.8.1.1-9.1988.

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The spectrins are a family of widely distributed filamentous proteins. In association with actin, spectrins form a supporting and organizing scaffold for cell membranes. Using antibodies specific for human brain alpha-spectrin (alpha-fodrin), we have cloned a rat brain alpha-spectrin cDNA from an expression library. Several closely related human clones were also isolated by hybridization. Comparison of sequences of these and other overlapping nonerythroid and erythroid alpha-spectrin genes demonstrated that the nonerythroid genes are strictly conserved across species, while the mammalian eryth
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Leto, T. L., D. Fortugno-Erikson, D. Barton, et al. "Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species." Molecular and Cellular Biology 8, no. 1 (1988): 1–9. http://dx.doi.org/10.1128/mcb.8.1.1.

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The spectrins are a family of widely distributed filamentous proteins. In association with actin, spectrins form a supporting and organizing scaffold for cell membranes. Using antibodies specific for human brain alpha-spectrin (alpha-fodrin), we have cloned a rat brain alpha-spectrin cDNA from an expression library. Several closely related human clones were also isolated by hybridization. Comparison of sequences of these and other overlapping nonerythroid and erythroid alpha-spectrin genes demonstrated that the nonerythroid genes are strictly conserved across species, while the mammalian eryth
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Lawler, J., TL Coetzer, VN Mankad, RB Moore, JT Prchal, and J. Palek. "Spectrin-alpha I/61: a new structural variant of alpha-spectrin in a double-heterozygous form of hereditary pyropoikilocytosis." Blood 72, no. 4 (1988): 1412–15. http://dx.doi.org/10.1182/blood.v72.4.1412.1412.

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Abstract Recent biochemical studies have led to the identification of abnormal spectrins in the erythrocytes of patients with hereditary pyropoikilocytosis (HPP) and hereditary elliptocytosis (HE). In this report we describe the biochemical characterization of the erythrocytes from a proband with severe HPP who is doubly heterozygous for two mutant spectrins (Sp): Sp alpha I/74 and a new, previously undetected, mutant of alpha-spectrin designated Sp alpha I/61. The proband's erythrocytes are unstable when exposed to 45 degrees C, and her membrane skeletons exhibit instability to shear stress.
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Lawler, J., TL Coetzer, VN Mankad, RB Moore, JT Prchal, and J. Palek. "Spectrin-alpha I/61: a new structural variant of alpha-spectrin in a double-heterozygous form of hereditary pyropoikilocytosis." Blood 72, no. 4 (1988): 1412–15. http://dx.doi.org/10.1182/blood.v72.4.1412.bloodjournal7241412.

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Recent biochemical studies have led to the identification of abnormal spectrins in the erythrocytes of patients with hereditary pyropoikilocytosis (HPP) and hereditary elliptocytosis (HE). In this report we describe the biochemical characterization of the erythrocytes from a proband with severe HPP who is doubly heterozygous for two mutant spectrins (Sp): Sp alpha I/74 and a new, previously undetected, mutant of alpha-spectrin designated Sp alpha I/61. The proband's erythrocytes are unstable when exposed to 45 degrees C, and her membrane skeletons exhibit instability to shear stress. The conte
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Dissertations / Theses on the topic "Spectrine"

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Legendre, Kirian. "La βV spectrine, quand une spectrine défie les conventions dans les cellules ciliées auditives et visuelles". Paris 6, 2010. http://www.theses.fr/2010PA066580.

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Ponceau, Aurélie. "Spectrine et adhérence cellulaire : implication de la spectrine dans la formation et les fonctions des podosomes." Paris 7, 2012. http://www.theses.fr/2012PA077168.

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Les spectrines (Sp), protéines liant l’actine, présentes dans toutes les cellules constituent les filaments flexibles sous forme de tétramères (alpha bêta)2 d'un squelette sous-membranaire de diverses membranes cellulaires. Dans les globules rouges de mammifères, la Sp (alphalbetal) participe à la résistance et la stabilité nie mbr an aire. Dans les cellules nucléées, leurs fonctions sont moins bien définies : elles participeraient à l'organisation de domaines membranaires spécialisés. Ce travail porte sur le rôle de l’alphaII-spectrine dans les podosomes, structures d'adhérence très dynamique
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Papal, Samantha. "La spectrine βv, une spectrine géante dans les cellules sensorielles visuelles et auditives, ses fonctions et son évolution". Paris 6, 2013. http://www.theses.fr/2013PA066139.

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Le syndrome de Usher (USH) est la cause la plus fréquente de surdité-cécité héréditaire chez l’Homme. USH1B est causé par une mutation dans le gène codant la myosine VIIa. Pour comprendre le rôle de cette myosine dans la dystrophie rétinienne, nous avons identifié et caractérisé son interaction avec une spectrine dite non-conventionnelle, la spectrine βV, dans les cellules photoréceptrices de la rétine. Nos avons montré que la spectrine βV s’associe également à d’autres protéines USH1, l’opsine et d’autres protéines de la phototransduction, et à des moteurs moléculaires associés aux microtubul
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Metral, Sylvain. "Etude des fonctions de la spectrine α non érythroïde". Phd thesis, Université Paris-Diderot - Paris VII, 2009. http://tel.archives-ouvertes.fr/tel-00377569.

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Le squelette dépendant de la spectrine, localisé sous la bicouche lipidique, est un échafaudage essentiel de toutes les cellules animales. La Spectrine (Sp), structure géante, robuste mais flexible d'hétéro tétramères (αβ)2, constitue les filaments de ce réseau, dont chaque nœud interagit avec des filaments d'actine. Les fonctions du squelette de Sp, qui sont bien définies dans le globule rouge (rôle dans sa forme, dans sa résistance aux forces de cisaillement et dans sa déformabilité) sont moins bien connues dans les cellules non-érythroïdes. La Sp non-érythroïde pourrait participer à l'étab
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Metral, Sylvain. "Etude des fonctions de la spectrine α non érythroide". Paris 7, 2009. http://www.theses.fr/2009PA077027.

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Le squelette dépendant de la spectrine, localisé sous la bicouche lipidique, est un échafaudage essentiel de toutes les cellules animales. La Spectrine (Sp), structure géante, robuste mais flexible d'hétéro tétramères (αβ)2, constitue les filaments de ce réseau, dont chaque nœud interagit avec des filaments d'actine. Les fonctions du squelette de Sp, qui sont bien définies dans le globule rouge (rôle dans sa forme, dans sa résistance aux forces de cisaillement et dans sa déformabilité) sont moins bien connues dans les cellules non-érythroïdes. La Sp non-érythroïde pourrait participer à l'établ
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FRAPPIER, THIERRY. "Etude des interactions fonctionnelles de la spectrine, des neurofilaments et des microfilaments : caracterisation biochimique des domaines d'interaction de la spectrine et des neurofilaments." Paris 6, 1990. http://www.theses.fr/1990PA066510.

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La spectrine a d'abord ete decrite et caracterisee dans les erythrocytes humains ou elle a, entre autres fonctions, de former un reseau sous-membranaires avec l'actine f, et d'ancrer ce reseau a la membrane par l'intermediaire de l'ankyrine. Mais la spectrine n'est pas uniquement trouvee dans les erythrocytes, puisqu'elle est repartie dans tout le regne animal, d'acanthamoeba jusqu'aux mammiferes. Si ces spectrines ont des fonctions communes (liaison a l'actine f); elles peuvent aussi presenter des fonctions propres. Nous avons montre que la spectrine de cerveau etait apte a se lier aux neurof
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Wilmotte, Rick. "Étude d'un allèle α-spectrine : allèle αLELY (low expression Lyon)". Lyon 1, 1996. http://www.theses.fr/1996LYO1T201.

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Rotter, Björn. "Etude fonctionnelle de la région centrale de l'alpha-II spectrine." Paris 7, 2004. http://www.theses.fr/2004PA077156.

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Reboulot, Brigitte. "L'elliptocytose hereditaire : revue de la litterature a propos d'une observation." Nice, 1988. http://www.theses.fr/1988NICE6548.

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Montout, Lory. "Exploration in silico d'une mini spectrine, l'α-actinine : dynamique et interactions". Paris 7, 2011. http://www.theses.fr/2011PA077232.

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La superfamille des spectrines est un groupe important de protéines du cytosquelette. Bien qu'ayant des fonctions très différentes, les membres de cette famille partagent un niveau surprenant d'homologie structurale, et sont composés de domaines conservés tels que les répétitions spectrines, les domaines CH de liaison à l'actine et les mains EF. Jusqu'à présent, des études ont porté sur les propriétés mécaniques de 2 à 3 unités répétitives de la spectrine ou sur le "rod domain" de l'alpha-actinine, sans tenir compte du rôle potentiel des domaines globulaires. Dans ces travaux de thèse, la méca
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Books on the topic "Spectrine"

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Shatner, William. Spectre. BCA, 1998.

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Spectre. New English Library, 1994.

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Weldon, Phaedra. Spectre. Penguin USA, Inc., 2008.

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Shatner, William. Spectre. Pocket Books, 1998.

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Spectre. Black Radish Books, 2010.

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Tismaneanu, Vladimir. Spectrele Europei Centrale. Polirom, 2001.

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Shirodaira, Kyō. In/spectre. Kodansha America, Incorporated, 2018.

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Allen, Chester. Spectre range. Linford, 1986.

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Brien, Sylvie. Le spectre. Éditions Porte-bonheur, 2007.

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Shirodaira, Ky. In/spectre. Kodansha America, Incorporated, 2017.

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Book chapters on the topic "Spectrine"

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Czogalla, Aleksander. "Spectrin." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101871.

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Czogalla, Aleksander. "Spectrin." In Encyclopedia of Signaling Molecules. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101871-1.

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Ralston, Greg B. "Spectrin-Actin Interactions." In Blood Cell Biochemistry. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4757-9528-8_8.

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Gruss, Daniel. "Spectre." In Encyclopedia of Cryptography, Security and Privacy. Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-642-27739-9_1687-1.

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Moeglin, Colette, and Jean-Loup Waldspurger. "Stabilisation spectrale." In Stabilisation de la formule des traces tordue. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30058-0_5.

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Lecomte, Marie-Christine. "Spectrins in Human Diseases." In Cytoskeleton and Human Disease. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-788-0_17.

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Bretto, Alain, Alain Faisant, and François Hennecart. "Automorphismes — Théorie spectrale." In Éléments de théorie des graphes. Springer Paris, 2012. http://dx.doi.org/10.1007/978-2-8178-0281-7_9.

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Griffith, Chris, and Leif Wells. "Testing with Spectron." In Electron: From Beginner to Pro. Apress, 2017. http://dx.doi.org/10.1007/978-1-4842-2826-5_14.

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Verdonck-de Leeuw, I. M. "Spectrale analyse van stemkwaliteit." In Handboek Stem– Spraak– Taalpathologie. Bohn Stafleu van Loghum, 1999. http://dx.doi.org/10.1007/978-90-313-8642-0_83.

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Peters, H. F. M., R. Bastiaanse, J. Van Borsel, et al. "Spectrale analyse van stemkwaliteit." In Stemstoornissen. Bohn Stafleu van Loghum, 2014. http://dx.doi.org/10.1007/978-90-368-0808-8_27.

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Conference papers on the topic "Spectrine"

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Sato, Munehiko, Shigeo Yoshida, Alex Olwal, et al. "SpecTrans." In CHI '15: CHI Conference on Human Factors in Computing Systems. ACM, 2015. http://dx.doi.org/10.1145/2702123.2702169.

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Martin, Jean-Philippe, Christopher J. Rossbach, and Michael Isard. "SPECTRE." In the Second Asia-Pacific Workshop. ACM Press, 2011. http://dx.doi.org/10.1145/2103799.2103821.

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Mayer, Ruben, Ahmad Slo, Muhammad Adnan Tariq, Kurt Rothermel, Manuel Gräber, and Umakishore Ramachandran. "SPECTRE." In Middleware '17: 18th International Middleware Conference. ACM, 2017. http://dx.doi.org/10.1145/3135974.3135983.

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Day, Jeremy, Yizhou Huang, Edward Knapp, and Ian Goldberg. "SPEcTRe." In the 10th annual ACM workshop. ACM Press, 2011. http://dx.doi.org/10.1145/2046556.2046565.

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Lykotrafitis, George, and He Li. "Two-Component Coarse-Grain Model for Erythrocyte Membrane." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-62133.

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Biological membranes are vital components of living cells as they function to maintain the structural integrity of the cells. Red blood cell (RBC) membrane comprises the lipid bilayer and the cytoskeleton network. The lipid bilayer consists of phospholipids, integral membrane proteins, peripheral proteins and cholesterol. It behaves as a 2D fluid. The cytoskeleton is a network of spectrin tetramers linked at the actin junctions. It is connected to the lipid bilayer primarily via Band-3 and ankyrin proteins. In this paper, we introduce a coarse-grained model with high computational efficiency f
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Klisnick, A., O. Guilbaud, J. P. Goddet, et al. "Caractérisation spectrale des lasers XUV." In UVX 2010 - 10e Colloque sur les Sources Cohérentes et Incohérentes UV, VUV et X ; Applications et Développements Récents. EDP Sciences, 2011. http://dx.doi.org/10.1051/uvx/2011013.

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Dhavlle, Abhijitt, Setareh Rafatirad, Houman Homayoun, and Sai Manoj Pudukotai Dinakarrao. "CR-Spectre: Defense-Aware ROP Injected Code-Reuse Based Dynamic Spectre." In 2022 Design, Automation & Test in Europe Conference & Exhibition (DATE). IEEE, 2022. http://dx.doi.org/10.23919/date54114.2022.9774750.

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Amos, Ben, Niv Gilboa, and Arbel Levy. "Spectre without shared memory." In SAC '19: The 34th ACM/SIGAPP Symposium on Applied Computing. ACM, 2019. http://dx.doi.org/10.1145/3297280.3297470.

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Mishra, Kamini, Abhijit Chakrabarty, and Puspendu K. Das. "Spectrin-hemoglobin interaction studied by second harmonic light scattering." In International Conference on Fibre Optics and Photonics. OSA, 2016. http://dx.doi.org/10.1364/photonics.2016.tu4a.73.

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Kocher, Paul, Jann Horn, Anders Fogh, et al. "Spectre Attacks: Exploiting Speculative Execution." In 2019 IEEE Symposium on Security and Privacy (SP). IEEE, 2019. http://dx.doi.org/10.1109/sp.2019.00002.

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Reports on the topic "Spectrine"

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Shen, B. W., F. J. Stevens, U. Luthi, and S. B. Goldin. Structural basis of spectrin elasticity. Office of Scientific and Technical Information (OSTI), 1991. http://dx.doi.org/10.2172/10148966.

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De Camilli, Pietro. Beta IV Spectrin in Normal and Cancer Breast Cells. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada418127.

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Olive, Daniel, Edward Lum, Erin Sosebee, and Steven Simmonds. SPECTRE Thermal Bench Test Preliminary Results. Office of Scientific and Technical Information (OSTI), 2020. http://dx.doi.org/10.2172/1716732.

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Broesius, Michael T. The spectre of uncertainty in communicating technological risk. Office of Scientific and Technical Information (OSTI), 1993. http://dx.doi.org/10.2172/10143021.

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Kotula, Leszek, Jiliu Xu, Jill A. Macoska, Piotr Kozlowski, and Magdalena Martinka. The Role of Human Spectrin SH3 Domain Binding Protein 1 (HSSH3BPl) in Prostatic Adenocarcinoma. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada430579.

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Kotula, Leszek, Jiliu XU, Jill A. Macoska, Piotr Kozlowski, and Magdalena Martinka. The Role of Human Spectrin SH3 Domain Binding Protein 1 (HSSH3BP1) in Prostatic Adenocarcinoma. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada411959.

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Kotula, Leszek, Jiliu Xu, Jill A. Macoska, Piotr Kozlowski, Magdalena Martinka, and Edward C. Jones. The Role of Human Spectrin SH3 Domain Binding Protein 1 (HSSH3BP1) in Prostatic Adenocarcinoma. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada419543.

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Blok, Pieter, Jochen Hemming, Henk-Jan Holterman, Jean-Marie Michielsen, and Jos Ruizendaal. Precisietechnologie Tuinbouw: PPS Autonoom onkruid verwijderen : D2.4 Literatuurstudie spectrale reflectie-eigenschappen van planten en onkruiden; D2.5 Lab en veldexperimenten spectrale reflectie-eigenschappen van planten en onkruiden. Wageningen Plant Research, Business unit Glastuinbouw, 2018. http://dx.doi.org/10.18174/442084.

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Lee, Sheryn. KMT stumbling may mean the spectre of Beijing is losing its potency in Taipei. East Asia Forum, 2015. http://dx.doi.org/10.59425/eabc.1420153003.

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Hoving, I. E., J. van Riel, G. Holshof, et al. Schatten van grasopbrengst op basis van spectrale reflectie, grashoogte en modellering : Onderzoeksresultaten van een maaiproef op zand- klei en veengrond 2016-2017. Wageningen Livestock Research, 2019. http://dx.doi.org/10.18174/508117.

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