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Dissertations / Theses on the topic 'Spermatogenesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Wahlgren, Aida. "Growth factors in spermatogenesis /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-579-4/.

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2

Allenby, Gary. "Chemical disruption of spermatogenesis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/18841.

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Over the past decade many publications attest to the substantial increase in public and scientific concern regarding the potential of industrial and environmental chemicals to interfere with male reproductive function. Spermatogenesis, (the process of sperm formation) depends on a series of complex biological interactions which can be interrupted at various stages by chemical insult. Recently a number of these chemicals have been used experimentally to directly disrupt testicular function to provide an insight into the processes involved in normal spermatogenesis. Based on these investigations

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3

Turner, Katie Jane. "Prospects for monitoring spermatogenesis." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/21577.

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The aims of the studies in this thesis were, firstly, to investigate the feasibility of detecting proteins derived from the seminiferous epithelium in testicular interstitial fluid, spermatic vein blood, testicular vein blood and also in peripheral blood. Secondly, to identify proteins might be potential markers of adverse effects on spermatogenesis. An antiserum was raised against seminiferous tubule secreted proteins and was used in conjunction with Western blot analysis to detect testicular proteins in biological fluids and also to screen a testis cDNA library to identify novel secretory pr

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4

Vries, Johannes Wilhelmus Albertus de. "The DAZ genes and impaired spermatogenesis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/86215.

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5

Shoji, Masanobu. "RNA interference during spermatogenesis in mice." Kyoto University, 2006. http://hdl.handle.net/2433/143821.

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6

Tam, Yuen-tsung. "Spatiotemporal expression of VAD1.2/AEP2 in spermatogenesis." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39558071.

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7

Jue, Kathleen. "Regulation of DNA methyltransferase expression during spermatogenesis." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22746.

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Patterns of methylation at the 5-position of cytosine are postulated to be involved in several mammalian processes such as the regulation of gene expression, genomic imprinting and X chromosome inactivation. Disruptions in methylation patterns affect embryonic development and are involved in carcinogenesis, indicating the importance of regulating these patterns. The establishment of methylation patterns is believed to be initiated during gametogenesis and continue during early embryonic development. DNA (cytosine-5)-methyltransferase (EC2.1.1.37) (DNA methyltransferase) is the only known mamma

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8

Tam, Yuen-tsung, and 譚婉頌. "Spatiotemporal expression of VAD1.2/AEP2 in spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39558071.

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9

Gao, Jing, and 高晶. "Roles of VAD1.3 in spermatogenesis and fertilization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B4852170X.

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　　Vad1.3 is an evolutionarily-conserved, testis-specific gene identified from a retinol-treated Vitamin A-deficiency (VAD) rat model. VAD1.3 is expressed throughout spermiogenesis at the acrosome of spermatids and epididymal spermatozoa, suggesting a role in acrosome biogenesis or acrosome reaction. The present study aimed to explore the functional role of VAD1.3 in spermatogenesis and sperm functions by the cellular and gene-knockout approaches. 　　Double immunofluorescent microscopy confirmed the co-localization of VAD1.3 and syntaxin 1 in mouse spermatids and spermatozoa. Deletion analysi

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10

Al-Jaru, Ayman I. "Equine spermatogenesis : meiotic chromosome behavior and recombination." Thesis, University of Central Lancashire, 2010. http://clok.uclan.ac.uk/1762/.

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Studying the spermatogenesis of horse is beneficial for the horse industry by identifying the causes of chromosomal abnormalities, which cause embryonic loss, congenital abnormalities and infertility. Little is known about the spermatogenesis in horse. This is the first report that investigates the horse spermatogenesis in detail, particularly metaphase I (MI) and prophase I (PI) stages of the first meiotic division. Meiotic recombination is considered to be the major outcome of meiosis. It is essential for proper chromosome segregation and formation of normal haploid gametes. Analysis of reco

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11

Silva, Sílvia Isabel Ferreira da. "APP is a critical protein in spermatogenesis." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14858.

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Mestrado em Biomedicina Molecular<br>The Amyloid precursor protein (APP) and Tau protein are related to histopathological hallmarks of Alzheimer’s disease, a progressive and complex neurodegenerative disease. APP is a type 1 integral transmembrane glycoprotein. There are two predominant proteolytic processing pathways of APP, the nonamyloidogenic pathway, and the amyloidogenic pathway. Tau is one of the microtubule-associated proteins, and its binding affinity for microtubules is regulated by phosphorylation of serine and threonine residues. APP and Tau protein expression has also been

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12

Yeung, Seen-yu Aurora, and 楊善如. "Regulation and functional studies of the testis-specific temperature-related sequence 4 (TRS4) in spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208024.

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Temperature-related sequence 4 (Trs4) is a transcript identified from the testis of a cryptorchid rat model. TRS4 is firstly detected in round spermatids on postnatal day 21 mice, and is localized on the acrosome and tails of elongating spermatids and mature spermatozoa, suggesting a role in spermatogenesis. The present study aimed to investigate the regulatory and functional roles of Trs4 in spermatogenesis. To investigate the hormonal regulation of Trs4 in vitro, mouse germ cell were co-cultured with Sertoli (TM4) cell-line for 24 hours with 1μM or 10nM testosterone and the expression of

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13

Venables, Julian. "Interactions of RBM, a candidate human spermatogenesis factor." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29655.

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Development can be seen as the consequence of alternative gene expression in different cell types. The focus of this study is the hierarchy of gene expression that controls the process of spermatogenesis, at the RNA level. RBM is an RNA-binding protein (encoded by the Y chromosome) thought to be important for the production of sperm. Its primary structure is reminiscent of SR protein splicing factors and it colocalises with them in the nucleus of germ line cells in the testes. If RBM were involved in splicing it should interact with components of the splicing machinery, so a yeast two-hybrid s

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14

Tarabay, Yara. "Functional studies of mouse Tex19 paralogs during spermatogenesis." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ091.

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La spermatogenèse est le processus par lequel les cellules germinales se différencient pour former les spermatozoides. Elle se déroule à l’intérieur des tubes séminifères. Pendant la période embryonnaire, les précurseurs des cellules germinales adultes constituent un pool de cellules appelées cellules germinales primordiales (Primordial Germ Cells, PGCs), qui vont migrer pour aller coloniser les gonades (Durcova-Hills and Capel, 2008; Surani et al., 2008). Au cours de leur migration, les PGCs vont subir une reprogrammation épigénétique de l’ensemble de leur génome, qui leur sera nécessaire pou

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15

Chakrabarti, Rumela. "Role for PP1γ2 in spermatogenesis and sperm morphogenesis". Kent State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=kent1176430377.

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16

Serrano, Joana Margarida Bispo. "LAP1 interactome and its functional features throughout spermatogenesis." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/16051.

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Mestrado em Biomedicina Molecular<br>The lamina-associated polypeptide 1 (LAP1) is a type II transmembrane protein of the inner nuclear membrane encoded by the human gene TOR1AIP1. LAP1 is involved in maintaining the nuclear envelope structure and appears be involved in the positioning of lamins and chromatin. In the nuclear envelope, LAP1 is suggested to exist as a complex with A-type and B-type lamins, torsins and emerin. The presence of such complexes suggests that LAP1 may cooperate functionally with these proteins in tissues where they play a critical role. Therefore, the identification o

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17

Tiedau, Daniela. "Tudor domain containing protein 6 and its essential role in murine spermatogenesis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-24900.

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Expression of the Tudor domain containing protein 6 (TDRD6), which is restricted to the male germ line, starts at day 16 of spermatogenesis, i.e. in pachytene spermatocytes. TDRD6 is a 250 kDa protein, which we recently found to be cleaved at the C-terminal end during germ cell development, resulting in a 230 kDa product. Neither is the process of cleavage itself nor are the functions of the two different forms known. The 230 kDa isoform is the most prominent form in round spermatids, where it localizes to the chromatoid body (CB), i.e. a single filamentous, perinuclear granule. One character

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18

Vara, González Covadonga. "Chromatin remodeling during mouse spermatogenesis: functional and evolutionary implications." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670959.

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La línia germinal conté el passat i el futur d’una espècie, en la qual la informació genètica parental es recombina mitjançant la meiosi i és transmesa a la descendència. Així, entendre com el genoma s’organitza i es regula en l’espai nuclear durant la formació de cèl·lules germinals és essencial per comprendre les bases de la fertilitat i el seu impacte en la diversitat genètica. En cèl·lules somàtiques, el genoma s’organitza en territoris cromosòmics que estan formats per compartiments de cromatina plegats en dominis d’associació topològica (TADs) i bucles d’ADN. No obstant això, es coneix p

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19

Kamaruddin, Musaddin Bin. "Heat shock protein 70 in bovine spermatogenesis and fertilization." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ33307.pdf.

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20

Washington, Nicole Leanne. "Regulation of Membrane Fusion Events During Caenorhabditis elegans Spermatogenesis." Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1405%5F1%5Fm.pdf&type=application/pdf.

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21

Walden, Charlotte. "The effects of N-butyldeoxynojirimycin on spermatogenesis in mice." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436999.

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22

Bowgen, C. "Characterisation of gene expression during spermatogenesis in mammalian species." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596826.

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In studies carried out previously, transcripts that are expressed in the testis were isolated from a human adult testis cDNA library. The characterisation of these cDNA clones was carried out by a number of methods. In order to determine the sizes of the transcripts and the tissues in which they are expressed, the clones were analysed by Northern blotting using human multiple tissue blots. It was seen that out of the 38 clones analysed, four were exclusively expressed in the testis and a further 17 were preferentially expressed in the testis, suggesting that they may have a role in testis func

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23

Mok, Ka-wai, and 莫嘉維. "Blood testis barrier: its biology and significance in spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49799502.

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Spermatogenesis takes place in the seminiferous epithelium and it is a tightly regulated process that produces spermatozoa from spermatogonia. During spermatogenesis, germ cells have to traverse the seminiferous epithelium, from basal to adluminal compartment and finally reach the luminal edge of the seminiferous tubules at spermiation. During the transit of germ cells, they have to get across the blood-testis barrier (BTB), which is formed by adjacent Sertoli cells. Thus, although BTB is considered as one of the tightest blood-tissue barrier, the BTB undergoes cyclic restructuring to “open”

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24

West, M. "Effects of dietary phytoestrogens on spermatogenesis and sperm function." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426916.

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25

Potash, Jesse. "The role of Cdyl and CDY in mammalian spermatogenesis." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/34579.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2006.<br>Includes bibliographical references (leaves 106-114).<br>Mouse Cdyl was originally identified based on homology to the human gene CDY (Lahn and Page, 1999), which is found in four copies on the human Y chromosome (Kuroda-Kawaguchi et al., 2001). Because CDY is expressed specifically in the testis (Lahn and Page, 1999) and is found in Y chromosomal regions that are deleted in some infertile men (Kuroda-Kawaguchi et al., 2001), CDY is thought to have an important role in male fertility and spermatogenesis. However

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26

Dudiki, Tejasvi. "SERINE/THREONINE PHOSPHATASES: ROLE IN SPERMATOGENESIS AND SPERM FUNCTION." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1416354965.

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27

Nogueras, de Minniti Alicia Susana. "Molecular and genetic analysis of spermatogenesis in Caenorhabditis elegans." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186978.

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For cells to function in a complex organism, they must differentiate and acquire their specific morphology. To study how cells achieve this I have chosen the spermatozoon of the nematode Caenorhabditis elegans. Genes involved in virtually every step of sperm development have been identified by mutations in C. elegans and these mutations dissect the process of differentiation. During spermiogenesis spherical non-motile spermatids differentiate into bipolar amoeboid spermatozoa. Chapters II and III describe the characterization of two genes that affect this differentiation. For both genes, spe-2

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28

Washington, Nicole Leanne. "Regulation of Membrane Fusion Events During Caenorhabditis elegans Spermatogenesis." Diss., The University of Arizona, 2005. http://hdl.handle.net/10150/195114.

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FER-1 is required for fusion of specialized vesicles, called membranous organelles, with the sperm plasma membrane during Caenorhabditis elegans spermiogeneis. To investigate the role of FER-1 in membranous organelle fusion, I first examined ten fer-1 mutations and found that they all cause the same defect in membrane fusion. FER-1 and the ferlin protein family are membrane proteins with four to seven C2 domains which commonly mediate Ca2+-dependent lipid-processing events. Most of the fer-1 mutations fall within these C2 domains, showing that they have distinct, non-redundant functions. I fou

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29

Ruggiu, Matteo. "The function of DAZL and RBM, two candidate fertility genes." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300014.

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30

Heninger, Noah Leland III. "The role of testicular germ cell apoptosis during equine spermatogenesis." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4691.

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Apoptosis in testicular germ cells has been demonstrated in many species. Features of apoptosis reported in other species were used to confirm use of the TUNEL assay in stallion testes. Eight stallions with normal testicular size and semen quality were evaluated to determine the germ cell types and stages where apoptosis most commonly occurs. Mean numbers of TUNEL-positive germ cells per 100 Sertoli cell nuclei were highest in stages IV and V of the seminiferous epithelial cycle corresponding to meiotic divisions of primary spermatocytes and mitotic proliferation of B1 and B2 spermatogonia. Ro

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31

Li, Wing-man Michelle, and 李穎雯. "Gap junction regulates the blood-testis barrier dynamics during spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45450225.

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32

Shivdasani, Anish Anil. "Hedgehog signalling, TGF-Î² signalling and spermatogenesis in Drosophila melanogaster." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408836.

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33

Laurentino, Sandra Filipa Tomás Sequeira. "Sexual steroid regulation of spermatogenesis: new actors enter the stage." Doctoral thesis, Universidade da Beira Interior, 2011. http://hdl.handle.net/10400.6/942.

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Spermatogenesis, the process of male gamete (i.e. spermatozoa) production, requires tight hormonal regulation in order to proceed successfully. The importance of androgens (like testosterone and 5α-dihydrotestosterone) to the regulation of spermatogenesis is well recognized. However, more recently, the importance of estrogens (like 17β-estradiol), has also been demonstrated. These sexual steroids act through ligand-activated transcription factors, estrogen receptors α and β (ERα and ERβ) and androgen receptor (AR), respectively. Most actions of these hormones are achieved through the regulatio

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34

Ramdas, Shandilya. "Role of PP1γ2 Binding Partners in Spermatogenesis and Sperm Function". Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1352418328.

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35

Chakrabarti, Rumela. "Role for PP1 [gamma] 2 in spermatogenesis and sperm morphogenesis." [Kent, Ohio] : Kent State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1176430377.

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Thesis (Ph.D.)--Kent State University, 2007.<br>Title from PDF t.p. (viewed Mar. 12, 2009). Advisor: Srinivasan Vijayaraghavan. Keywords: sperm, testes, spermatogenesis, protein phosphatase, knock out, spermatid. Includes bibliographical references (p. 115-129).

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36

Zuo, Yan, and 左妍. "Gene targeting to study a novel acrosome specific gene VAD1.3/AEP1 in spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41634251.

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37

Zhang, Xu, and 张栩. "Regulation of testicular cell junction dynamics." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206351.

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38

Floros, Vasileios. "An investigation of the role of Notch signalling in germ cell development using mouse embryonic stem cells." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2282.

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39

Zuo, Yan. "Gene targeting to study a novel acrosome specific gene VAD1.3/AEP1 in spermatogenesis." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41634251.

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40

Thompson, Kristjan Louise Sperry Ann O. "The role of Axl and Axl-like proteins in murine spermatogenesis." [Greenville, N.C.] : East Carolina University, 2009. http://hdl.handle.net/10342/2219.

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Thesis (Ph.D.)--East Carolina University, 2009.<br>Presented to the faculty of the Department of Anatomy and Cell Biology. Advisor: Ann O. Sperry. Title from PDF t.p. (viewed June 12, 2010). Includes bibliographical references.

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41

Smendziuk, Christopher Michael. "Bi-directional gap junction-mediated soma-germline communication during Drosophila spermatogenesis." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57897.

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Soma-germline interactions play conserved essential roles in regulating cell proliferation, differentiation, patterning, and homeostasis in the gonad. In the Drosophila testis, the JAK-STAT, Hedgehog, BMP and EGF pathways are used to mediate soma-germline communication via paracrine signalling. In this thesis, I aim to shed light on the role of juxtacrine signalling, mediated by gap junction proteins, during early spermatogenesis in the fly testis. My analysis demonstrates that gap junctions also mediate direct, bi-directional signalling between the soma and germline. When gap junctions betwee

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42

Pang, Zhiyu. "Functions of the ubiquitin system in mammalian spermatogenesis and skeletal muscle." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96699.

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The conjugation of ubiquitin to proteins is catalyzed sequentially by a cascade of members of three classes of enzymes – ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2), and ubiquitin protein ligase (E3). Polyubiquitinated protein substrates are selectively targeted for degradation by the proteasome. Removal of ubiquitin from ubiquitinated substrates is catalyzed by deubiquitinating enzymes (DUB). In this thesis, I have explored functions of three specific enzymes of the ubiquitin system, the E2 UBC4-testis, the HECT E3 EDD/Rat100 and the deubiquitinating enzyme USP19, in m

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43

Tang, Lingfeng. "THE JAK/STAT PATHWAY IS REUTILIZED IN DROSOPHILA SPERMATOGENESIS." UKnowledge, 2014. http://uknowledge.uky.edu/biology_etds/27.

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In the Drosophila testis, sperm are derived from germline stem cells (GSCs) which undergo a stereotyped pattern of divisions and differentiation. The somatic cells at the tip of the testis form the hub, which is the niche for both the somatic cyst stem cells (CySCs) and GSCs. The hub expresses Upd, a ligand for the JAK/STAT pathway that has roles in the maintenance of CySCs and GSCs. Male mutants of upd3, another ligand of the JAK/STAT pathway, become sterile much earlier than the wild-type, leading to the hypothesis that similar to upd, upd3 also promotes the self-renewal of stem cells in tes

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44

Gao, Jing, and 高晶. "Effect of acupuncture on the spermatogenesis of heat-treated rodent testis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41291001.

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45

Romer, Katherine A. "Deciphering the mitotic and meiotic phases of spermatogenesis in the mouse." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/107076.

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Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Mammalian spermatogenesis includes two types of cell divisions. First, germ cells undergo transit-amplifying mitotic divisions, which enable prodigious output of mature spermatozoa. Second, they undergo reductive meiotic divisions to produce haploid gametes. In this thesis, I examine gene expression and regulation during the mitotic and meiotic phases of spermatogenesis. Chapter 2 describes how RA-STRA8 signa

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46

McLaren, Tanya Thomson. "Identification of potential marker proteins of toxicant-induced damage to spermatogenesis." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/20011.

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Spermatogenesis involves a complex series of cell-cell interactions which are probably mediated by secreted proteins. The primary objective of the studies described in this thesis was therefore to identify specific proteins which change in relative abundance in the early stages of toxicant-induced damage to spermatogenesis and which might have potential use as markers of such damage. Identification of such proteins might pin-point the possible biochemical causes of the toxic effects on the testis, and also give insight into normal control mechanisms in spermatogenesis. The chemicals used in th

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47

Gao, Jing. "Effect of acupuncture on the spermatogenesis of heat-treated rodent testis." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41291001.

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48

Davies, Holly Gibs. "MSY4, a sequence-specific RNA binding protein expressed during mouse spermatogenesis /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/10307.

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49

Lawera, Aleksandra Anna. "The role of tubulin polyglutamylation and its potential effectors in spermatogenesis." Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20161.

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Les microtubules sont des éléments du cytosquelette, composées d'hétérodimères de tubuline de type α et β. Ils jouent un rôle important dans plusieurs processus cellulaires, dont le transport cytoplasmique, la mobilité et la division cellulaire. Cependant, les mécanismes par lesquels les microtubules sont adaptés à ces rôles très différents restent largement méconnus.Les modifications post-traductionnelles de la tubuline pourraient contribuer à la diversité de fonction des microtubules. Parmi celles-ci, la polyglutamylation pourrait jouer un rôle important en changeant d'une manière importante

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50

Bryan, Emily Rose. "Chronic Chlamyida infections in males: Impacts on testicular function and spermatogenesis." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/119158/1/Emily_Bryan_Thesis.pdf.

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Approximately 131 million Chlamydia trachomatis infections occur annually. The rates of infection are similar between males and females, but female infections have been more widely characterised. C. trachomatis causes infertility in men and women but little is known about the male disease. This study investigated the ability of chronic infections to cause male infertility. In mice, Chlamydia colonises specialised testicular cells, resulting in partial destruction of the testicular structure and production of anti-sperm-antibodies. This correlates with decline in sperm health and the egg-bindin

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