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Journal articles on the topic 'Spermatogenesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Moretti, Elena, Giulia Collodel, Giuseppe Belmonte, Daria Noto, and Emanuele Giurisato. "Defective spermatogenesis and testosterone levels in kinase suppressor of Ras1 (KSR1)-deficient mice." Reproduction, Fertility and Development 31, no. 8 (2019): 1369. http://dx.doi.org/10.1071/rd18386.

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The aim of this study was to clarify the role of the protein kinase suppressor of Ras1 (KSR1) in spermatogenesis. Spermatogenesis in ksr1−/− mice was studied in testicular tissue and epididymal spermatozoa by light and transmission electron microscopy and by immunofluorescence using antibodies to ghrelin and 3β-hydroxysteroid dehydrogenase (3β-HSD). Blood testosterone levels were also assessed. ksr1−/− mice showed reduced epididymal sperm concentration and motility as compared with wild-type (wt) mice. Testis tissue from ksr1−/− mice revealed a prevalent spermatogenetic arrest at the spermatoc

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2

de Kretser, D. M., K. L. Loveland, A. Meinhardt, D. Simorangkir, and N. Wreford. "Spermatogenesis." Human Reproduction 13, suppl 1 (1998): 1–8. http://dx.doi.org/10.1093/humrep/13.suppl_1.1.

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3

Nishimura, Hitoshi, and Steven W. L’Hernault. "Spermatogenesis." Current Biology 27, no. 18 (2017): R988—R994. http://dx.doi.org/10.1016/j.cub.2017.07.067.

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4

Rodriguez-Sosa, Jose R., and Ina Dobrinski. "Recent developments in testis tissue xenografting." REPRODUCTION 138, no. 2 (2009): 187–94. http://dx.doi.org/10.1530/rep-09-0012.

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Development of the mammalian testis and spermatogenesis involve complex processes of cell migration, proliferation, differentiation, and cell–cell interactions. Although our knowledge of these processes has increased in the last few decades, many aspects still remain unclear. The lack of suitable systems that allow to recapitulate and manipulate both testis development and spermatogenesisex situhas limited our ability to study these processes. In the last few years, two observations suggested novel strategies that will improve our ability to study and manipulate mammalian spermatogenesis: i) t

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5

Guha, T., A. Q. Siddiqui, and P. F. Prentis. "Ultrastructure of primary spermatocyte in fish (Tilapia: Oreochromis niloticus): The synaptonemal complex." Proceedings, annual meeting, Electron Microscopy Society of America 44 (August 1986): 288–89. http://dx.doi.org/10.1017/s0424820100143067.

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The Primary Spermatocytes represent a stage in spermatogenesis when the first meiotic cell division occurs. They are derived from Spermatogonium or Stem cell through mitotic division. At the zygotene phase of meiotic prophase the Synaptonemal complex appears in these cells in the space between the paired homologous chromosomes. Spermatogenesis and sperm structure in fish have been studied at the electron microscope level in a few species? However, no work has yet been reported on ultrastructure of tilapia, O. niloticus, spermatozoa and spermatogenetic process. In this short communication we ar

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6

Rahadi, Yustisiane Ruth, Tri Wahyu Suprayogi, Rahmi Sugihartuti, Kadek Rachmawati, and Hani Plumeriastuti. "Effect of taurine on histopathological features of spermatogenesis in seminiferous tubules of mice (Mus musculus) induced by paraquat." Ovozoa : Journal of Animal Reproduction 11, no. 2 (2022): 66–71. http://dx.doi.org/10.20473/ovz.v11i2.2022.66-71.

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This study aimed to determine the effect of taurine on the enhancement of the spermatogenetic process in male mice (Mus musculus) induced by paraquat (PQ). Twenty-five male mice (Mus musculus) aged 2-3 months with a bodyweight of around 35 grams were divided randomly into five groups. The K + and the treatment group (P1, P2, and P3) mice were induced using PQ. PQ was given intraperitoneally (IP) twice a week for 21 consecutive days at a dose of 30 mg/kg BW. Two hours after the administration of PQ, P1, P2, and P3 groups were given taurine at a dose of 250, 500, and 1000 mg/kg BW/day for three

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7

Meccariello, Rosaria, Rosanna Chianese, Vincenza Ciaramella, Silvia Fasano, and Riccardo Pierantoni. "Molecular Chaperones, Cochaperones, and Ubiquitination/Deubiquitination System: Involvement in the Production of High Quality Spermatozoa." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/561426.

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Spermatogenesis is a complex process in which mitosis, meiosis, and cell differentiation events coexist. The need to guarantee the production of qualitatively functional spermatozoa has evolved into several control systems that check spermatogenesis progression/sperm maturation and tag aberrant gametes for degradation. In this review, we will focus on the importance of the evolutionarily conserved molecular pathways involving molecular chaperones belonging to the superfamily of heat shock proteins (HSPs), their cochaperones, and ubiquitination/deubiquitination system all over the spermatogenet

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8

Rodrigues, Ramon T. G. A., José R. S. Santos, Lilianne M. S. Azerêdo, et al. "Influence of scrotal bipartition on spermatogenesis yield and sertoli cell efficiency in sheep." Pesquisa Veterinária Brasileira 36, no. 4 (2016): 258–62. http://dx.doi.org/10.1590/s0100-736x2016000400002.

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Abstract With the objective to assess the effect of scrotal bipartition on spermatogenesis in sheep, the testes were used from 12 crossbred rams of sheep farms in the municipality of Patos, Paraíba, Brazil, distributed into two groups: GI with six rams with scrotal bipartition, and GII with six rams without scrotal bipartition. The testicular biometry was measured and the testes were collected, fixed in Bouin and fragments were processed to obtain histological slides. The spermatogenesis yield and the Sertoli cell efficiency was estimated by counting the cells of the spermatogenetic line at st

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9

Akdeniz, Ekrem, Mehmet Emin Onger, Mustafa Suat Bolat, et al. "Effect of atorvastatin on spermatogenesis in rats: A stereological study." Tropical Journal of Pharmaceutical Research 19, no. 12 (2021): 2609–14. http://dx.doi.org/10.4314/tjpr.v19i12.19.

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Purpose: To investigate the effects of oral atorvastatin on spermatogenesis in a rat model.Methods: Rats were equally assigned into control and study groups, the latter receiving atorvastatin (20 mg/kg/day). At the end of 12 weeks, spermatogenetic activity was evaluated using stereological and optical fractionator methods. Serum follicle-stimulating hormone (FSH), total testosterone (TT), and luteinizing hormone (LH) levels were measured using micro–ELISA kits. Total cholesterol, triglyceride (TG), low-density lipoprotein cholesterol (LDL - C), and high-density lipoprotein cholesterol levels w

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10

Gribbins, Kevin. "Reptilian spermatogenesis." Spermatogenesis 1, no. 3 (2011): 250–69. http://dx.doi.org/10.4161/spmg.1.3.18092.

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11

Yushin, Vladimir, and Alexander Ryss. "Sperm development and structure in Bursaphelenchus mucronatus (Nematoda: Aphelenchoidea: Aphelenchoididae)." Nematology 13, no. 4 (2011): 395–407. http://dx.doi.org/10.1163/138855410x526840.

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AbstractSpermatogenesis in Bursaphelenchus mucronatus, described using TEM, is similar to that of the 'rhabditid' nematodes. The development includes formation of complexes of fibrous bodies (FB) and membranous organelles (MO) which appear in spermatocytes; the complexes dissociate in the spermatids; the immature sperm contains separate FB and MO and transformation continues only after activation in the female gonoduct. The spermatheca contains mature spermatozoa as bipolar cells subdivided into one large pseudopod and a main cell body containing a nucleus without a nuclear envelope, numerous

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12

TERADA, HIROSHI, KIMIO FUJITA, ATSUSHI OTSUKA, HITOSHI SHINBO, SOICHI MUGIYA, and SEIICHIRO OZONO. "Oral clonidine advances spermatogenesis in oligozoospermic patients with spermatogenetic maturation arrest." International Journal of Urology 12, no. 9 (2005): 815–20. http://dx.doi.org/10.1111/j.1442-2042.2005.01144.x.

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13

Zhang, J., R. Yan, C. Wu, et al. "Spermatogenesis-associated 48 is essential for spermatogenesis in mice." Andrologia 50, no. 6 (2018): e13027. http://dx.doi.org/10.1111/and.13027.

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14

Wang, Hao-Qi, Tian Wang, Fei Gao, and Wen-Zhi Ren. "Application of CRISPR/Cas Technology in Spermatogenesis Research and Male Infertility Treatment." Genes 13, no. 6 (2022): 1000. http://dx.doi.org/10.3390/genes13061000.

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As the basis of animal reproductive activity, normal spermatogenesis directly determines the efficiency of livestock production. An in-depth understanding of spermatogenesis will greatly facilitate animal breeding efforts and male infertility treatment. With the continuous development and application of gene editing technologies, they have become valuable tools to study the mechanism of spermatogenesis. Gene editing technologies have provided us with a better understanding of the functions and potential mechanisms of action of factors that regulate spermatogenesis. This review summarizes the a

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15

RUSSELL, LONNIE D., and RALPH L. BRINSTER. "Ultrastructural Observations of Spermatogenesis Following Transplantation of Rat Testis Cells Into Mouse Seminiferous Tubules." Journal of Andrology 17, no. 6 (1996): 615–27. http://dx.doi.org/10.1002/j.1939-4640.1996.tb01845.x.

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ABSTRACT: The testes of busulfan‐treated immunodeficient mice receiving seminiferous tubuie injections of testis cells from rats were examined by light and electron microscopy. The presence of active rat spermatogenesis was verified by criteria that are known to characterize spermatogenic cells of this species. In addition, spermatogenesis from the mouse was identified as taking place in some seminiferous tubules as the result of reinitiation of spermatogenesis after busulfan treatment. Rat spermatogenesis in mouse seminiferous tubules showed the generally recognized associations of cells know

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16

Divya, V. "Dynamics of Spermatogenesis." Annual Research & Review in Biology 4, no. 1 (2014): 38–50. http://dx.doi.org/10.9734/arrb/2014/4289.

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17

Sharpe, R. M. "Testosterone and spermatogenesis." Journal of Endocrinology 113, no. 1 (1987): 1–2. http://dx.doi.org/10.1677/joe.0.1130001.

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18

Song, Hye-Won, and Miles F. Wilkinson. "In vitro spermatogenesis." Spermatogenesis 2, no. 4 (2012): 238–44. http://dx.doi.org/10.4161/spmg.22069.

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19

O'Donnell, L. "Estrogen and Spermatogenesis." Endocrine Reviews 22, no. 3 (2001): 289–318. http://dx.doi.org/10.1210/er.22.3.289.

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20

O’Donnell, Liza, Kirsten M. Robertson, Margaret E. Jones, and Evan R. Simpson. "Estrogen and Spermatogenesis*." Endocrine Reviews 22, no. 3 (2001): 289–318. http://dx.doi.org/10.1210/edrv.22.3.0431.

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Abstract Although it has been known for many years that estrogen administration has deleterious effects on male fertility, data from transgenic mice deficient in estrogen receptors or aromatase point to an essential physiological role for estrogen in male fertility. This review summarizes the current knowledge on the localization of estrogen receptors and aromatase in the testis in an effort to understand the likely sites of estrogen action. The review also discusses the many studies that have used models employing the administration of estrogenic substances to show that male fertility is resp

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21

Trasler, Jacquetta M. "Epigenetics in spermatogenesis." Molecular and Cellular Endocrinology 306, no. 1-2 (2009): 33–36. http://dx.doi.org/10.1016/j.mce.2008.12.018.

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22

Carreau, Serge, and Rex A. Hess. "Oestrogens and spermatogenesis." Philosophical Transactions of the Royal Society B: Biological Sciences 365, no. 1546 (2010): 1517–35. http://dx.doi.org/10.1098/rstb.2009.0235.

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The role of oestrogens in male reproductive tract physiology has for a long time been a subject of debate. The testis produces significant amounts of oestrogenic hormones, via aromatase, and oestrogen receptors (ERs)α (ESR1) and ERβ (ESR2) are selectively expressed in cells of the testis as well as the epididymal epithelium, depending upon species. This review summarizes the current knowledge concerning the presence and activity of aromatase and ERs in testis and sperm and the potential roles that oestrogens may have in mammalian spermatogenesis. Data show that physiology of the male gonad is

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23

White-Cooper, Helen, and Nina Bausek. "Evolution and spermatogenesis." Philosophical Transactions of the Royal Society B: Biological Sciences 365, no. 1546 (2010): 1465–80. http://dx.doi.org/10.1098/rstb.2009.0323.

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Sexual reproduction depends on the production of haploid gametes, and their fusion to form diploid zygotes. Here, we discuss sperm production and function in a molecular and functional evolutionary context, drawing predominantly from studies in model organisms (mice, Drosophila , Caenorhabditis elegans ). We consider the mechanisms involved in establishing and maintaining a germline stem cell population in testes, as well as the factors that regulate their contribution to the pool of differentiating cells. These processes involve considerable interaction between the germline and the soma, and

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24

McDonough, Paul G., Hans J. Duvekot, and Ruud C. P. M. van Muyden. "Inhibition of Spermatogenesis." Fertility and Sterility 46, no. 2 (1986): 341–43. http://dx.doi.org/10.1016/s0015-0282(16)49542-7.

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25

O’Donnell, Liza, and Moira K. O’Bryan. "Microtubules and spermatogenesis." Seminars in Cell & Developmental Biology 30 (June 2014): 45–54. http://dx.doi.org/10.1016/j.semcdb.2014.01.003.

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26

Yan Cheng, C. "Biology of spermatogenesis." Seminars in Cell & Developmental Biology 29 (May 2014): 1. http://dx.doi.org/10.1016/j.semcdb.2014.04.031.

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27

Schulz, Rüdiger W., Luiz Renato de França, Jean-Jacques Lareyre, et al. "Spermatogenesis in fish." General and Comparative Endocrinology 165, no. 3 (2010): 390–411. http://dx.doi.org/10.1016/j.ygcen.2009.02.013.

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28

Tüttelmann, Frank, Christian Ruckert, and Albrecht Röpke. "Disorders of spermatogenesis." medizinische genetik 30, no. 1 (2018): 12–20. http://dx.doi.org/10.1007/s11825-018-0181-7.

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29

Xu, Chen, Ding Li, Jian Qiang Bao, Shao Feng Cao, and Yi Fei Wang. "MicroRNAs and Spermatogenesis." Biology of Reproduction 78, Suppl_1 (2008): 54. http://dx.doi.org/10.1093/biolreprod/78.s1.54.

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30

Weidner, W., T. Diemer, and M. Bergmann. "Aging and spermatogenesis." Aging Health 2, no. 1 (2006): 53–58. http://dx.doi.org/10.2217/1745509x.2.1.53.

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31

Ma, Dan-Dan, Da-Hui Wang, and Wan-Xi Yang. "Kinesins in spermatogenesis†." Biology of Reproduction 96, no. 2 (2017): 267–76. http://dx.doi.org/10.1095/biolreprod.116.144113.

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32

SANYAL, S., P. B. PATRA, S. NAG, and N. M. BISWAS. "Indomethacin & Spermatogenesis." Andrologia 12, no. 2 (2009): 179–85. http://dx.doi.org/10.1111/j.1439-0272.1980.tb00609.x.

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33

Silver, Lee M. "Spermatogenesis: Genetic aspects." Cell 52, no. 4 (1988): 485–86. http://dx.doi.org/10.1016/0092-8674(88)90461-8.

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34

Jankovic Velickovic, Ljubinka, and Vladisav Stefanovic. "Hypoxia and spermatogenesis." International Urology and Nephrology 46, no. 5 (2013): 887–94. http://dx.doi.org/10.1007/s11255-013-0601-1.

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35

Stewart Irvine, D. "Assessment of spermatogenesis." Current Obstetrics & Gynaecology 2, no. 1 (1992): 20–26. http://dx.doi.org/10.1016/0957-5847(92)90006-w.

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36

Chirumbolo, Salvatore. "Resveratrol in spermatogenesis." Cell Biology International 39, no. 7 (2015): 775–76. http://dx.doi.org/10.1002/cbin.10451.

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37

Johnson, Larry. "Efficiency of spermatogenesis." Microscopy Research and Technique 32, no. 5 (1995): 385–422. http://dx.doi.org/10.1002/jemt.1070320504.

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38

Roveri, Antonella, Fulvio Ursini, Leopold Flohé, and Matilde Maiorino. "PHGPx and spermatogenesis." BioFactors 14, no. 1-4 (2001): 213–22. http://dx.doi.org/10.1002/biof.5520140127.

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39

Kotaja, Noora. "MicroRNAs and spermatogenesis." Fertility and Sterility 101, no. 6 (2014): 1552–62. http://dx.doi.org/10.1016/j.fertnstert.2014.04.025.

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40

Hennig, W. "Spermatogenesis in Drosophila." International Journal of Developmental Biology 40, no. 1 (1996): 167–76. https://doi.org/10.1387/ijdb.8735926.

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A short summary on the present knowledge on spermatogenesis in Drosophila is given which also points out particular questions of interest in the context of this morphogenetic process. Such points of interest are the formation of lampbrush loops in primary spermatocytes, the chromosomal events during meiosis, the occurrence of chromatin rearrangements and the regulation of gene activities at the posttranscriptional level. The activities and some major conclusions from my laboratory are subsequently described. They include studies of the expression of histone variants, the structure and function

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41

Miura, Takeshi, Chiemi Miura, Yasuko Konda, and Kohei Yamauchi. "Spermatogenesis-preventing substance in Japanese eel." Development 129, no. 11 (2002): 2689–97. http://dx.doi.org/10.1242/dev.129.11.2689.

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Under fresh-water cultivation conditions, spermatogenesis in the Japanese eel is arrested at an immature stage before initiation of spermatogonial proliferation. A single injection of human chorionic gonadotropin can, however, induce complete spermatogenesis, which suggests that spermatogenesis-preventing substances may be present in eel testis. To determine whether such substances exist, we have applied a subtractive hybridisation method to identify genes whose expression is suppressed after human chorionic gonadotropin treatment in vivo. We found one previously unidentified cDNA clone that w

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42

Zhang, Yu, Qiu-Meng Xiang, Chang-Kao Mu, Chun-Lin Wang, and Cong-Cong Hou. "Functional Study of PTSMAD4 in the Spermatogenesis of the Swimming Crab Portunus trituberculatus." International Journal of Molecular Sciences 25, no. 23 (2024): 13126. https://doi.org/10.3390/ijms252313126.

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Portunus trituberculatus holds significant economic value. The spermatogenesis is regulated by numerous signaling pathways. Among them, the TGF-β signaling pathway plays an important role in the development of testes and spermatogenesis. Smad4 is a Co-Smad protein that forms a complex with R-Smad to regulate the expression of target genes. The sperm structure in crustaceans differs greatly from that in mammals, with mature sperm lacking tails. Our previous studies have reported the function of R-Smad in the spermatogenesis of P. trituberculatus. In this study, we cloned the full-length cDNA se

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43

Zhou, Yu, and Yunyan Wang. "Action and Interaction between Retinoic Acid Signaling and Blood–Testis Barrier Function in the Spermatogenesis Cycle." Cells 11, no. 3 (2022): 352. http://dx.doi.org/10.3390/cells11030352.

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Spermatogenesis is a complex process occurring in mammalian testes, and constant sperm production depends on the exact regulation of the microenvironment in the testes. Many studies have indicated the crucial role of blood–testis barrier (BTB) junctions and retinoic acid (RA) signaling in the spermatogenesis process. The BTB consists of junctions between adjacent Sertoli cells, comprised mainly of tight junctions and gap junctions. In vitamin A-deficient mice, halted spermatogenesis could be rebooted by RA or vitamin A administration, indicating that RA is absolutely required for spermatogenes

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44

Cheng, C. Yan, and Dolores D. Mruk. "The biology of spermatogenesis: the past, present and future." Philosophical Transactions of the Royal Society B: Biological Sciences 365, no. 1546 (2010): 1459–63. http://dx.doi.org/10.1098/rstb.2010.0024.

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The physiological function of spermatogenesis in Caenorhabditis elegans , Drosophila melanogaster and mammals is to produce spermatozoa (1n, haploid) that contain only half of the genetic material of spermatogonia (2n, diploid). This half number of chromosomes from a spermatozoon will then be reconstituted to become a diploid cell upon fertilization with an egg, which is also haploid. Thus, genetic information from two parental individuals can be passed onto their offspring. Spermatogenesis takes place in the seminiferous epithelium of the seminiferous tubule, the functional unit of the mammal

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45

Xiong, Yi, Chao Yu, and Qianting Zhang. "Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis." Cells 11, no. 6 (2022): 1058. http://dx.doi.org/10.3390/cells11061058.

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Spermatogenesis is a prolonged and highly ordered physiological process that produces haploid male germ cells through more than 40 steps and experiences dramatic morphological and cellular transformations. The ubiquitin proteasome system (UPS) plays central roles in the precise control of protein homeostasis to ensure the effectiveness of certain protein groups at a given stage and the inactivation of them after this stage. Many UPS components have been demonstrated to regulate the progression of spermatogenesis at different levels. Especially in recent years, novel testis-specific proteasome

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46

Chen, Yan, Xiaoliang Li, Huijuan Liao, et al. "CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A†." Biology of Reproduction 101, no. 1 (2019): 50–62. http://dx.doi.org/10.1093/biolre/ioz062.

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Abstract MicroRNAs (miRNAs) have recently been shown to be important for spermatogenesis; both DROSHA and Dicer1 KO mice exhibit infertility due to abnormal miRNA expression. However, the roles of individual miRNAs in spermatogenesis remain elusive. Here we demonstrated that miR-15b, a member of the miR-15/16 family, is primarily expressed in testis. A miR-15b transgenic mouse model was constructed to investigate the role of miR-15b in spermatogenesis. Impaired spermatogenesis was observed in miR-15b transgenic mice, suggesting that appropriate expression of miR-15b is vital for spermatogenesi

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47

Li, Yanan, Xiang Liu, Xianghui Zhang, et al. "Single-Cell RNA Sequencing of the Testis of Ciona intestinalis Reveals the Dynamic Transcriptional Profile of Spermatogenesis in Protochordates." Cells 11, no. 24 (2022): 3978. http://dx.doi.org/10.3390/cells11243978.

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Spermatogenesis is a complex and continuous process of germ-cell differentiation. This complex process is regulated by many factors, of which gene regulation in spermatogenic cells plays a decisive role. Spermatogenesis has been widely studied in vertebrates, but little is known about spermatogenesis in protochordates. Here, for the first time, we performed single-cell RNA sequencing (scRNA-seq) on 6832 germ cells from the testis of adult Ciona intestinalis. We identified six germ cell populations and revealed dynamic gene expression as well as transcriptional regulation during spermatogenesis

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48

HUANG, H. F. S., T. A. LINSENMEYER, R. ANESETTI, W. GIGLIO, J. E. OTTENWELLER, and L. POGACH. "Suppression and Recovery of Spermatogenesis Following Spinal Cord Injury in the Rat." Journal of Andrology 19, no. 1 (1998): 72–80. http://dx.doi.org/10.1002/j.1939-4640.1998.tb02472.x.

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ABSTRACT: Recently, we reported that changes in spermatogenesis in adult rats during acute phase (within 2 weeks) of spinal cord injury (SCI) were associated with a suppression of pituitary‐testis hormone axis, and these effects mimic those that occur after hormone deprivation. In this study, we examined the long‐term (>4 weeks) effects of SCI on spermatogenesis and its recovery. Results of this study reveal that while serum follicle stimulating hormone, luteinizing hormone, and testosterone levels in SCI rats recovered within 1 month after the injury, their spermatogenesis continued to reg

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49

Wang, Li, Jingqian Wang, Xinming Gao, et al. "Characterization of Mitochondrial Prohibitin in Opsariichthys bidens and Its Potential Functions in Spermatogenesis." International Journal of Molecular Sciences 23, no. 13 (2022): 7295. http://dx.doi.org/10.3390/ijms23137295.

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Spermatogenesis is the intricate and coordinated process by which spermatogonia develop into haploid differentiated spermatozoa. Mitochondria are essential for spermatogenesis, and prohibitin (PHB) is closely associated with mitochondrial structure and function during spermatogenesis. Although PHB has been implicated in spermatogenesis in some taxa, its roles in Opsariichthys bidens have not been determined. In this study, the expression patterns and potential functions of PHB in spermatogenesis in O. bidens were characterized using histological microscopic observations, PCR cloning, real-time

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50

Hasbi, Hasbi, and Sri Gustina. "Androgen Regulation in Spermatogenesis to Increase Male Fertility." Indonesian Bulletin of Animal and Veterinary Sciences 28, no. 1 (2018): 13. http://dx.doi.org/10.14334/wartazoa.v28i1.1643.

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<p class="00-6Abstrak2Wtz">Male fertility is affected by quantity and quality of sperm which controlled by androgens (testosterone and 5α-dihydrotestosterone) mediated by androgen receptors (AR). Androgen receptors belong to receptor group of steroid hormone and a group of ligand-activated nuclear receptor superfamily. This paper explains androgen hormone and its regulation in spermatogenesis to increase male fertility. Regulation of androgen hormone in spermatogenesis include initiation of spermatogenesis, proliferation and maturation of Sertoli cells, germ cell development, spermatogon

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