Academic literature on the topic 'Spermidina'

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Journal articles on the topic "Spermidina"

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Lee, Jung Yeop, Brian K. Janes, Karla D. Passalacqua, et al. "Biosynthetic Analysis of the Petrobactin Siderophore Pathway from Bacillusanthracis." Journal of Bacteriology 189, no. 5 (2006): 1698–710. http://dx.doi.org/10.1128/jb.01526-06.

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ABSTRACT The asbABCDEF gene cluster from Bacillus anthracis is responsible for biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence in a murine model of anthrax. We initiated studies to determine the biosynthetic details of petrobactin assembly based on mutational analysis of the asb operon, identification of accumulated intermediates, and addition of exogenous siderophores to asb mutant strains. As a starting point, in-frame deletions of each of the genes in the asb locus (asbABCDEF) were constructed. The individual mutations resulted in
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Ponasik, J. A., C. Strickland, C. Faerman, S. Savvides, P. A. Karplus, and B. Ganem. "Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase." Biochemical Journal 311, no. 2 (1995): 371–75. http://dx.doi.org/10.1042/bj3110371.

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The enzyme trypanothione reductase (TR), together with its substrate, the glutathione-spermidine conjugate trypanothione, plays an essential role in protecting parasitic trypanosomatids against oxidative stress and is a target for drug design. Here we show that a naturally occurring spermine derivative, the antihypertensive agent kukoamine A [N1N12-bis(dihydrocaffeoyl)-spermine] inhibits TR as a mixed inhibitor (Ki = 1.8 microM, Kii = 13 microM). Kukoamine shows no significant inhibition of human glutathione reductase (Ki > 10 mM) and thus provides a novel selective drug lead. The correspon
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Alves da Costa Ribeiro Quintans, Isadora Louise, Juliana Alves da Costa Ribeiro Souza, and Michael K. Deyholos. "Orbitides and free polyamines have similarly limited fungicidal activity against three common pathogens of flax in vitro." FACETS 7 (January 1, 2022): 843–52. http://dx.doi.org/10.1139/facets-2021-0201.

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Fusarium oxysporum f. sp. lini and Septoria linicola are causes of fusarium wilt and pasmo in flax ( Linum usitatissimum). Members of a third fungal genus, Alternaria spp., have also been found in fiber and linseed varieties of flax, and are a source of post-harvest spoilage and mycotoxins in a wide range of crops. We performed a microdilution assay and calculated the median effective concentration (EC50) to compare the potency of cyclolinopeptides (CLPs), two polyamines (spermidine and spermine), and the fungicide carbendazimin in the control of three fungi that have potential pathogenic acti
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Mercier, A. J., S. Farragher, B. Schmor, M. Kamau, and J. Atkinson. "Effect of a plant-derived spider toxin analogue on crayfish neuromuscular junctions." Canadian Journal of Zoology 76, no. 11 (1998): 2103–7. http://dx.doi.org/10.1139/z98-142.

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N8-Coumaroyl spermidine (N8-CS) is an example of hydroxycinnamic acid - polyamine conjugates found in certain plants. Because of its structural similarity to some spider toxins, N8-CS was tested for its ability to block arthropod neuromuscular synapses. It inhibited chemical synaptic transmission at crayfish (Procambarus clarkii) neuromuscular junctions, the IC50 being approximately 200 µM. Its effect was at least partially reversed by washing with physiological saline. Joro spider toxin, a structurally similar compound, also blocked crayfish neuromuscular synapses but its effect was irreversi
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Perrin, Jennifer, Natalja Kulagina, Marianne Unlubayir, et al. "Exploiting Spermidine N-Hydroxycinnamoyltransferase Diversity and Substrate Promiscuity to Produce Various Trihydroxycinnamoyl Spermidines and Analogues in Engineered Yeast." ACS Synthetic Biology 10, no. 2 (2021): 286–96. http://dx.doi.org/10.1021/acssynbio.0c00391.

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Hamana, Koei, and Shigeru Matsuzaki. "Polyamine distribution patterns serve as a phenotypic marker in the chemotaxonomy of the Proteobacteria." Canadian Journal of Microbiology 39, no. 3 (1993): 304–10. http://dx.doi.org/10.1139/m93-043.

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Polyamines of various genera of the class Proteobacteria were analyzed by high-performance liquid chromatography to determine if they can serve as taxonomic markers. The major polyamine of Zymomonas was homospermidine, whereas the Acetobacter–Gluconobacter complex contained spermidine, suggesting the presence of two different polyamine distribution patterns in the alpha subclass. Both the homospermidine-dominant type and the spermidine-dominant type were found in heterogeneous Sphingomonas species. Typical species belonging to the gamma subclass have their own unique polyamine pattern in Xanth
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Wei, Wan. "A comprehensive literature review of spermidine." Theoretical and Natural Science 46, no. 1 (2024): 9–13. http://dx.doi.org/10.54254/2753-8818/46/20240934.

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This review explores the role of spermidine, a naturally occurring polyamine, in promoting healthy aging and increasing lifespan. Spermidine was initially discovered in human sperm, and it is important in several cellular processes across eukaryotic organisms. We deeply study the historical background of spermidine discovery and its research developments. The paper examines the mechanisms through which spermidine influences lifespan, including its interaction with RNA, stimulation of autophagy, anti-inflammatory effects, and impact on the cell cycle. Each mechanism is discussed with its contri
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Higashi, Kyohei, Hiroyuki Ishigure, Risa Demizu, et al. "Identification of a Spermidine Excretion Protein Complex (MdtJI) in Escherichia coli." Journal of Bacteriology 190, no. 3 (2007): 872–78. http://dx.doi.org/10.1128/jb.01505-07.

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ABSTRACT A spermidine excretion protein in Escherichia coli was looked for among 33 putative drug exporters thus far identified. Cell toxicity and inhibition of growth due to overaccumulation of spermidine were examined in an E. coli strain deficient in spermidine acetyltransferase, an enzyme that metabolizes spermidine. Toxicity and inhibition of cell growth by spermidine were recovered in cells transformed with pUCmdtJI or pMWmdtJI, encoding MdtJ and MdtI, which belong to the small multidrug resistance family of drug exporters. Both mdtJ and mdtI are necessary for recovery from the toxicity
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Erwin, B. G., and A. E. Pegg. "Regulation of spermidine/spermine N1-acetyltransferase in L6 cells by polyamines and related compounds." Biochemical Journal 238, no. 2 (1986): 581–87. http://dx.doi.org/10.1042/bj2380581.

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Exposure of rat L6 cells in culture to exogenous polyamines led to a very large increase in the activity of spermidine/spermine N1-acetyltransferase. Spermine was more potent than spermidine in bringing about this increase, but in both cases the elevated acetyltransferase activity increased the cellular conversion of spermidine into putrescine. The N1-acetyltransferase turned over very rapidly in the L6 cells, with a half-life of 9 min after spermidine and 18 min after spermine. A wide variety of synthetic polyamine analogues also brought about a substantial induction of spermidine/spermine N1
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Liao, Chen-Yu, Oona M. P. Kummert, Amanda M. Bair, et al. "The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition." Journals of Gerontology: Series A 76, no. 10 (2021): 1714–25. http://dx.doi.org/10.1093/gerona/glab145.

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Abstract Autophagy, a process catabolizing intracellular components to maintain energy homeostasis, impacts aging and metabolism. Spermidine, a natural polyamine and autophagy activator, extends life span across a variety of species, including mice. In addition to protecting cardiac and liver tissue, spermidine also affects adipose tissue through unexplored mechanisms. Here, we examined spermidine in the links between autophagy and systemic metabolism. Consistently, daily injection of spermidine delivered even at late life is sufficient to cause a trend in life-span extension in wild-type mice
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Dissertations / Theses on the topic "Spermidina"

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Stöckle, Silke. "Thin liquid films with nanoparticles and rod-like ions as models for nanofluidics." Phd thesis, Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2010/4637/.

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With the rise of nanotechnology in the last decade, nanofluidics has been established as a research field and gained increased interest in science and industry. Natural aqueous nanofluidic systems are very complex, there is often a predominance of liquid interfaces or the fluid contains charged or differently shaped colloids. The effects, promoted by these additives, are far from being completely understood and interesting questions arise with regards to the confinement of such complex fluidic systems. A systematic study of nanofluidic processes requires designing suitable experimental model
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Almeida, Maria de Lurdes Soares de. "Selective protection of polyamines : Synthesis of spermidine derivatives." Doctoral thesis, Universidade do Porto. Reitoria, 1989. http://hdl.handle.net/10216/10192.

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Almeida, Maria de Lurdes Soares de. "Selective protection of polyamines : Synthesis of spermidine derivatives." Tese, Universidade do Porto. Reitoria, 1989. http://hdl.handle.net/10216/10192.

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Nadaraia-Hoke, Shorena Flanagan John M. "Structural and thermodynamic characterization of spermidine and spermine synthases." [University Park, Pa.] : Pennsylvania State University, 2009. http://etda.libraries.psu.edu/theses/approved/PSUonlyIndex/ETD-4555/index.html.

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Choucair, Bassima. "Synthèse des polyaminostérols, analogues de la squalamine, à propriétés antibiotique et anticancéreuse." Caen, 2003. http://www.theses.fr/2003CAEN3098.

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La squalamine est un polyaminostérol 3 -N-[3N-(4-aminobutyl)aminopropyl] aminocholestan-7 -ol-24R-sulfate qui a été isolé en 1993 de tissus du requin " Squalus acantias ". Cette molécule a montrée des propriétés antibiotique et anticancéreuse par inhibition de l'angiogénèse dans les tumeurs solides. Cependant, la squalamine est présente en quantités infimes dans les tissus du requin et sa synthèse nécessite plusieurs étapes. D'où l'intérêt de synthétiser des analogues désulfatés de la squalamine. Le polyamine a été introduit en position C-7 du cholestérol, en positions C-7 et C-6 du cholestano
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Catros, Véronique. "Implication des polyamines dans les processus proliferatifs malins." Rennes 1, 1990. http://www.theses.fr/1990REN1T085.

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Des etudes effectuees in vivo chez l'animal ainsi que chez des patients atteints de differents types histologiques de tumeurs, ont permis de montrer que le taux erythrocytaire de spermidine (spd) se comportait comme un index sanguin de la proliferation cellulaire tumorale. L'etude in vivo du metabolisme des polyamines (pa) apres administration de precurseurs radiomarques a des animaux porteurs de tumeurs greffees a permis d'apporter la preuve de l'origine tumorale de la spermidine erythrocytaire. Les modalites d'uptake des pa par les erythrocytes ont par ailleurs ete caracterisees in vitro: le
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Sanvura, Bashwira. "Myricoïdine et dihydromyricoïdine, nouveaux alcaloïdes macrocycliques dérivés de la spermidine." Doctoral thesis, Universite Libre de Bruxelles, 1990. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213135.

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Pham, Chinh Nghia. "Le métabolisme de l'inflammation dans les maladies microcristallines." Electronic Thesis or Diss., Université Paris Cité, 2024. http://www.theses.fr/2024UNIP5246.

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La goutte, due aux dépôts de cristaux d'urate monosodique (UMS), et la maladie liée aux dépôts des cristaux de pyrophosphate de calcium (PPC) sont les deux rhumatismes inflammatoires les plus fréquents de l'adulte. Les cristaux sont responsables de crises inflammatoires aiguës et récurrentes qui dépendent de la production de l'interleukine (IL)-1 beta via l'activation de l'inflammasome NLRP3. Ces crises inflammatoires peuvent être modulées par des facteurs environnementaux tels que les régimes alimentaires dont la restriction calorique (RC) ou le jeûne intermittent (JI). Les objectifs de ma th
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Suttmann, Rebecca T. "Purification and inhibition of spermidine N⁸-acetyltransferase from rat liver nuclei." Scholarly Commons, 1991. https://scholarlycommons.pacific.edu/uop_etds/2222.

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The naturally occurring polyamines play an essential role in cell growth and proliferation. The enzyme spermidine N8- acetyltransferase catalyzes the acetylation of spermidine utilizing acetyl-CoA as the acetyl donor. In this study, an in vitro acetyltransferase assay was used to determine the types of compounds which can inhibit this reaction. The enzyme was partially purified from rat liver nuclei and solubilized in 0.4 M KCl. The Km for spermidine was 0.47 mM. Studies on the nature of the active site indicated that: (i) a sulfhydryl group is essential for optimal activity as shown by inhibi
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Caron, Édith. "Étude de l'interaction entre l'actine et les polyamines : spermidine et spermine." Thèse, Université du Québec à Trois-Rivières, 1987. http://depot-e.uqtr.ca/5803/1/000560724.pdf.

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Books on the topic "Spermidina"

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Kauppinen, Leila. Human spermidine synthase: Purification, molecular cloning and expression. University of Kuopio, 1995.

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Sobolev, Victor S. The peanut plant and light: Spermidines from peanut flowers and studies of their photoisomerization. Nova Science Publishers, 2010.

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Sobolev, Victor S. The peanut plant and light: Spermidines from peanut flowers. Nova Science Publishers, 2010.

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Klose, Markus. Effects of a hydroxy-cinnamoyl conjugate of spermidine in the neuromuscular junction of crayfish. Brock University, Dept. of Biological Sciences, 2000.

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Hyvönen, Tapani. Isolation, characterization and inhibition of spermidine syntase and the consequences of sperimidine depletion in mammalian cells. University of Kuopio, Dept. of Biochemistry and Biotechnology, 1990.

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Tower, Paula Allene. Homospermidine, spermidine, and putrescine: The biosynthesis and metabolism of polyamines in Rhizobium meliloti. 1987.

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Manai, Faouzi. Isolierung und Sequenzierung des Glutathionyl-Spermidin-Synthetase-Gens aus dem Parasit Crithidia fasciculata. 1997.

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Onken, Tammo. Bedeutung der Aufnahme von exogenem Spermidin für die Regulation des intrazellulären Polyaminstoffwechsels beim stimulierten Pankreaswachstum der Ratte. 2005.

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Book chapters on the topic "Spermidina"

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Schomburg, D., M. Salzmann, and D. Stephan. "Spermidine dehydrogenase." In Enzyme Handbook 7. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78521-4_40.

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Schomburg, Dietmar, and Dörte Stephan. "Spermidine synthase." In Enzyme Handbook 13. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-59176-1_13.

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Rips, R., and C. Guette. "Determination of Polyamines (Spermine, Spermidine, Putrescine) in Biological Samples." In Contemporary Electroanalytical Chemistry. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3704-9_33.

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Zahedi, Kamyar, and Manoocher Soleimani. "Spermidine/Spermine-N1-Acetyltransferase in Kidney Ischemia Reperfusion Injury." In Methods in Molecular Biology. Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-034-8_24.

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Nampoothiri, Madhavan, Kiran Kumar Kolathur, Runali Sankhe, and Sairaj Satarker. "Spermidine, an Autophagy Inducer, as a Therapeutic Antiaging Strategy." In Emerging Anti-Aging Strategies. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-7443-4_8.

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Feirer, R. P., S. R. Wann, and D. W. Einspahr. "The effects of spermidine synthesis inhibitors on in-vitro plant development." In Polyamines in Plants. Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-5171-6_10.

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Perin, Antonio, Angela Sessa, and M. Alfonsina Desiderio. "Estrogenic Control of Spermidine/Spermine N1-Acetyltransferase Activity in Rat Uterus." In Progress in Polyamine Research. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5637-0_30.

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Sunkara, Prasad S., John H. Zwolshen, Nellikunja J. Prakash, and Terry L. Bowlin. "Mechanism of Antitumor Activity of Norspermidine, a Structural Homologue of Spermidine." In Progress in Polyamine Research. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5637-0_62.

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Tortolini, Cristina, Gabriele Favero, and Franco Mazzei. "Development of Amine-Oxidase-Based Biosensors for Spermine and Spermidine Analysis." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7398-9_7.

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Tabor, Herbert, and Celia White Tabor. "Biosynthesis and Metabolism of 1,4-diaminobutane, Spermidine, Spermine, and Related Amines." In Advances in Enzymology - and Related Areas of Molecular Biology. John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/9780470122815.ch7.

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Conference papers on the topic "Spermidina"

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KOPEL, Pavel, Natalia CERNEI, Pavel HORKY, et al. "MAGHEMITE PARTICLES FOR SPERMIDINE SEPARATION." In NANOCON 2019. TANGER Ltd., 2020. http://dx.doi.org/10.37904/nanocon.2019.8496.

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Senekowitsch, S., E. Wietkamp, M. Grimm, et al. "Hochdosierte Spermidin-Supplementation ohne Effekt auf Spermidin-Konzentration im Blut: Eine randomisierte, Placebo-kontrollierte pharmakokinetische Studie." In Nutrition 2023 | Dreiländertagung der Österreichischen Arbeitsgemeinschaft Klinische Ernährung (AKE), der Deutschen Gesellschaft für Ernährungsmedizin (DGEM) und der Gesellschaft für Klinische Ernährung der Schweiz˵ (GESKES). Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0043-1768125.

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KATSUMATA, SHUNJI, HARUNORI KIGASAWA, and KUNIHARU UTSUNO. "AFM STUDY ON CONDENSATION OF DNA BY SPERMIDINE." In Proceedings of the 8th Asia-Pacific Physics Conference. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812811523_0146.

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Shkodra, Bajramshahe, Mattia Petrelli, Martina Costa Angeli, et al. "Flexible carbon nanotube-based electrolyte-gated field-effect transistor for spermidine detection." In 2021 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS). IEEE, 2021. http://dx.doi.org/10.1109/fleps51544.2021.9469788.

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Murayama, Yoshihiro. "Reentrant Collapsing Transition of Single DNA Molecules: Elastic Response Depending on Spermidine Concentration." In SLOW DYNAMICS IN COMPLEX SYSTEMS: 3rd International Symposium on Slow Dynamics in Complex Systems. AIP, 2004. http://dx.doi.org/10.1063/1.1764157.

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Brett-Morris, Adina, Scott M. Welford, Eli Bar, et al. "Abstract 3954: SAT1 (Spermidine/spermine-N1-acetyltrasferase 1) promotes radiation resistance in glioblastoma multiforme." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3954.

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Shaker, Husham A., and Jwan A. Zainulabdeen. "Estimation the levels of spermidine and spermine in sera of inflammatory bowel disease patients." In PROCEEDING OF THE 1ST INTERNATIONAL CONFERENCE ON ADVANCED RESEARCH IN PURE AND APPLIED SCIENCE (ICARPAS2021): Third Annual Conference of Al-Muthanna University/College of Science. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0093817.

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Keller, Nicholas, and Douglas E. Smith. "Single-molecule studies of the effect of spermidine on DNA mechanics and viral DNA packaging." In SPIE NanoScience + Engineering, edited by Kishan Dholakia and Gabriel C. Spalding. SPIE, 2012. http://dx.doi.org/10.1117/12.930381.

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Ea, H. K., N. Pham, F. Finet, et al. "POS0187 INTERMITTENT FASTING AND SPERMIDINE REDUCE INFLAMMATION INDUCED BY MONOSODIUM URATE (MSU) AND CALCIUM PYROPHOSPHATE DIHYDRATE (CPPD) CRYSTALS." In EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria. BMJ Publishing Group Ltd and European League Against Rheumatism, 2024. http://dx.doi.org/10.1136/annrheumdis-2024-eular.3714.

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Park, S. W., M. Kim, A. R. Baek, J. H. Lee, A. S. Jang, and D. Kim. "Spermidine Attenuated Bleomycin Induced Lung Injury/Fibrosis by Inhibition of Endoplasmic Reticulum Stress (ers) Induced Apoptosis and Cellular Senescence." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5228.

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