Relevant bibliographies by topics / Spermidina / Dissertations / Theses
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Dissertations / Theses on the topic 'Spermidina'

Author: Grafiati
Published: 22 February 2023
Last updated: 29 July 2025

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1

Stöckle, Silke. "Thin liquid films with nanoparticles and rod-like ions as models for nanofluidics." Phd thesis, Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2010/4637/.

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With the rise of nanotechnology in the last decade, nanofluidics has been established as a research field and gained increased interest in science and industry. Natural aqueous nanofluidic systems are very complex, there is often a predominance of liquid interfaces or the fluid contains charged or differently shaped colloids. The effects, promoted by these additives, are far from being completely understood and interesting questions arise with regards to the confinement of such complex fluidic systems. A systematic study of nanofluidic processes requires designing suitable experimental model
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2

Almeida, Maria de Lurdes Soares de. "Selective protection of polyamines : Synthesis of spermidine derivatives." Doctoral thesis, Universidade do Porto. Reitoria, 1989. http://hdl.handle.net/10216/10192.

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3

Almeida, Maria de Lurdes Soares de. "Selective protection of polyamines : Synthesis of spermidine derivatives." Tese, Universidade do Porto. Reitoria, 1989. http://hdl.handle.net/10216/10192.

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4

Nadaraia-Hoke, Shorena Flanagan John M. "Structural and thermodynamic characterization of spermidine and spermine synthases." [University Park, Pa.] : Pennsylvania State University, 2009. http://etda.libraries.psu.edu/theses/approved/PSUonlyIndex/ETD-4555/index.html.

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5

Choucair, Bassima. "Synthèse des polyaminostérols, analogues de la squalamine, à propriétés antibiotique et anticancéreuse." Caen, 2003. http://www.theses.fr/2003CAEN3098.

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La squalamine est un polyaminostérol 3 -N-[3N-(4-aminobutyl)aminopropyl] aminocholestan-7 -ol-24R-sulfate qui a été isolé en 1993 de tissus du requin " Squalus acantias ". Cette molécule a montrée des propriétés antibiotique et anticancéreuse par inhibition de l'angiogénèse dans les tumeurs solides. Cependant, la squalamine est présente en quantités infimes dans les tissus du requin et sa synthèse nécessite plusieurs étapes. D'où l'intérêt de synthétiser des analogues désulfatés de la squalamine. Le polyamine a été introduit en position C-7 du cholestérol, en positions C-7 et C-6 du cholestano
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6

Catros, Véronique. "Implication des polyamines dans les processus proliferatifs malins." Rennes 1, 1990. http://www.theses.fr/1990REN1T085.

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Des etudes effectuees in vivo chez l'animal ainsi que chez des patients atteints de differents types histologiques de tumeurs, ont permis de montrer que le taux erythrocytaire de spermidine (spd) se comportait comme un index sanguin de la proliferation cellulaire tumorale. L'etude in vivo du metabolisme des polyamines (pa) apres administration de precurseurs radiomarques a des animaux porteurs de tumeurs greffees a permis d'apporter la preuve de l'origine tumorale de la spermidine erythrocytaire. Les modalites d'uptake des pa par les erythrocytes ont par ailleurs ete caracterisees in vitro: le
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7

Sanvura, Bashwira. "Myricoïdine et dihydromyricoïdine, nouveaux alcaloïdes macrocycliques dérivés de la spermidine." Doctoral thesis, Universite Libre de Bruxelles, 1990. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213135.

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8

Pham, Chinh Nghia. "Le métabolisme de l'inflammation dans les maladies microcristallines." Electronic Thesis or Diss., Université Paris Cité, 2024. http://www.theses.fr/2024UNIP5246.

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La goutte, due aux dépôts de cristaux d'urate monosodique (UMS), et la maladie liée aux dépôts des cristaux de pyrophosphate de calcium (PPC) sont les deux rhumatismes inflammatoires les plus fréquents de l'adulte. Les cristaux sont responsables de crises inflammatoires aiguës et récurrentes qui dépendent de la production de l'interleukine (IL)-1 beta via l'activation de l'inflammasome NLRP3. Ces crises inflammatoires peuvent être modulées par des facteurs environnementaux tels que les régimes alimentaires dont la restriction calorique (RC) ou le jeûne intermittent (JI). Les objectifs de ma th
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9

Suttmann, Rebecca T. "Purification and inhibition of spermidine N⁸-acetyltransferase from rat liver nuclei." Scholarly Commons, 1991. https://scholarlycommons.pacific.edu/uop_etds/2222.

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The naturally occurring polyamines play an essential role in cell growth and proliferation. The enzyme spermidine N8- acetyltransferase catalyzes the acetylation of spermidine utilizing acetyl-CoA as the acetyl donor. In this study, an in vitro acetyltransferase assay was used to determine the types of compounds which can inhibit this reaction. The enzyme was partially purified from rat liver nuclei and solubilized in 0.4 M KCl. The Km for spermidine was 0.47 mM. Studies on the nature of the active site indicated that: (i) a sulfhydryl group is essential for optimal activity as shown by inhibi
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10

Caron, Édith. "Étude de l'interaction entre l'actine et les polyamines : spermidine et spermine." Thèse, Université du Québec à Trois-Rivières, 1987. http://depot-e.uqtr.ca/5803/1/000560724.pdf.

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11

Garcie, Christophe. "Modulation atypique de la biosynthèse de la colibactine, une génotoxine de Escherichia coli, ou comment un îlot génomique est en symbiose avec le chromosome bactérien." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30283/document.

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L'îlot génomique pks code une machinerie de biosynthèse complexe synthétisant la colibactine, une génotoxine produite par certaines souches de Escherichia coli. Cette génotoxine induit des cassures double-brin de l'ADN sur les cellules eucaryotes in vitro et in vivo. La colibactine n'est pas une protéine, mais un métabolite secondaire de type polycétide/peptide non-ribosomal (PK/NRP). Des résultats préliminaires de l'équipe semblaient indiquer que certains gènes du core genome de E. coli seraient également impliqués dans la production de la colibactine. L'objectif de cette thèse était d'identi
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12

Kammula, Rao Karunakara. "Purification, characterization and inhibitor studies of rat liver nuclear spermidine N-acetyltransferase." Scholarly Commons, 1994. https://scholarlycommons.pacific.edu/uop_etds/2783.

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Polyamines are ubiquitously present in all living cells. The abnormal metabolism of polyamines that is associated with certain types of cancers has been the focus of several investigations. Enzymes that are involved in the transacetylation of polyamines have been studied extensively, so as to develop inhibitors of these enzymes which may be used as drugs in cancer therapy. Based on indirect evidence, the nuclear spermidine acetyltransferase has been thought to be a critical enzyme that is associated with genetic derepression leading to cancerous growth. In the present study a novel, rapid, sen
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13

Li, Jun. "A study of the role of spermidine/spermine N¹-acetyltransferase (SSAT) in polyamine homeostasis in human prostate cancer cells." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=210088.

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Prostate cancer is the second leading cancer in men. A large amount of polyamines are synthesised in the human prostate and are involved in prostate cell growth and its physiological functions. The content of intracellular polyamines is closely related to cell growth. An increase in cell growth is accompanied by a rise of intracellular polyamine content, and a depletion of intracellular polyamine pools can cause growth arrest or cell death. Therefore, maintaining polyamine concentrations is critical to the cell. Spermidine/spermine N1-acetyltransferase (SSAT) is the first and rate-limiting enz
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14

Warren, John C. III. "Evaluation of the Role of gsp, ygiC, and yjfC Genes in Glutathione Metabolism in Escherichia coli by Gene Disruption." Youngstown State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1310473424.

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15

Mackintosh, Caroline Anne. "Studies on the inhibition of plant pathogenic fungi by cyclohexylamine and spermidine analogues." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388547.

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16

Babbar, Naveen. "Regulation and function of spermidine/spermine N¹ acetyl transferase (SSAT) in colon carcinogenesis." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/289966.

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Epidemiological data suggest that non-steroidal anti-inflammatory drugs (NSAIDs) have anti-tumorigenic activities against colorectal cancer. NSAIDs work by inhibiting cyclooxygenases (COX) enzyme. Sulindac, a NSAID prodrug, is metabolized into pharmacologically active sulfide and sulfone derivatives. Microarray analysis was used to detect COX independent effects of sulindac on gene expression in human colorectal cells. Spermidine/spermine N 1-acetyl transferase (SSAT) gene, which encodes a polyamine catabolic enzyme, was one of the genes induced by clinically relevant sulindac sulfone concentr
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17

Chen, Alina. "New polyamine analogues as potential antineoplastic agents." Scholarly Commons, 2000. https://scholarlycommons.pacific.edu/uop_etds/2680.

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The naturally occurring polyamines play an essential role in cell growth and proliferation. The levels of polyamines have been shown to increase in rapidly proliferating cancer cells. Therefore, compounds that inhibit enzymes in polyamine biosynthetic pathway may have therapeutic potential. Compounds capable of providing both in vitro and in vivo inhibition of almost all enzymes in the polyamine biosynthetic pathway are known. An exception is the lack of an agent that inhibits spermidine/spermine N 1 -acetyltransferase (SSAT), the rate-limiting enzyme in the catabolism of polyamines. The desig
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18

Chakrabarti, Nilanjana. "Functional Analysis and Characterization of Transporter of Putrescine and Spermidine (TOPAS1) in Phytophthora parasitica." Bowling Green State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu149874256456224.

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19

Gingras, Yves. "L'effet inhibiteur des polyamines spermine et spermidine sur le complexe protéique du photosystème II /." Thèse, Trois-Rivières, Université du Québec à Trois-Rivières, 1998. http://www.uqtr.ca/biblio/notice/tablemat/03-2195690TM.html.

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Mémoire (M.Sc.) - Université du Québec à Trois-Rivières, 1998.<br>La table des matières est disponible en format électronique sur le site Web de la bibliothèque. CaQTU Bibliographie : f. [147]-158.
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20

Gingras, Yves. "L'effet inhibiteur des polyamines spermine et spermidine sur le complexe protéique du photosystème II." Thèse, Université du Québec à Trois-Rivières, 1998. http://depot-e.uqtr.ca/3546/1/000654648.pdf.

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21

Finokaliotou, Sophia. "Synthetic and biological studies of antiparasitic natural product derivatives." Thesis, University of Bath, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518105.

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Trypanosomiasis and Leishmaniasis are tropical diseases caused by the parasites Trypanosoma and Leishmania, that cause severe medical and economical problems for millions of people in the developing world. Trypanosomiasis can be divided into African and American trypanosomiasis, which are caused by Trypanosoma brucei and Trypanosoma cruzi respectively. There are more than 20 different species of Leishmania worldwide that cause Leishmaniasis, but the most severe infection, visceral leishmaniasis, is caused by Leishmania donovani. Both diseases are transmitted by blood sucking insects like the t
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22

Huang, Tien Liang. "Design, synthesis, and biological evaluation of inhibitors for N⁸-acetyspermidine deacetglase and spermidine N⁸-acetytransferase." Scholarly Commons, 1989. https://scholarlycommons.pacific.edu/uop_etds/2179.

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Previous studies active-site-directed metal coordinating reagents and substrate analogues of (N8-AcSpd) have indicated that the catalytic mechanism of N8-AcSpd deacetylase involved a transition state metal. Several ω-amino substituted carboxylic acids were tested and results confirmed the probability of the deacetylase having a mechanism similar to the metalloproteases. Based on these results, several analogues of spermidine containing metal coordinating ligands were designed and synthesized. In addition, a potential transition state analogue of the nuclear enzyme, spermidine N8-acetyltransfer
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23

Harkat, Mahboubi. "Etude moléculaire de la dilatation des récepteurs P2X." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ023.

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Les récepteurs P2X sont des canaux cationiques non sélectifs, perméables aux ions Na+, K+ et Ca2+. Leur activation par l’ATP, pour des potentiels de membrane proches du potentiel de repos des cellules, induit un influx de cations entraînant une dépolarisation membranaire. Les récepteurs P2X, issus de l’oligomérisation de trois sous-unités identiques (homotrimères) ou hétérologues (hétérotrimères), possèdent tous une partie hydrophobe transmembranaire et une partie hydrophile et glycosylée extracellulaire. Les récepteurs P2X sont impliqués dans de nombreux rôles physiologiques, et possèdent une
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24

Peters-Weigel, Sandra M. "Regulation of the speC gene encoding ornithine decarboxylase in Escherichia coli by putrescine, spermidine and cAMP." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-08182009-040534/.

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25

Deeb, Faten. "The role of spermidine in the regulation of development and differentiation in spermatids of Marsilea Vesitita." College Park, Md.: University of Maryland, 2009. http://hdl.handle.net/1903/9185.

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Thesis (Ph.D.) -- University of Maryland, College Park, 2009.<br>Thesis research directed by: Dept. of Cell Biology and Molecular Genetics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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26

Pietrocola, Federico. "Regulation of Autophagy by Acetyl Coenzime A : From the Mechanisms to a Revised Definition of Caloric Restriction Mimetics." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA11T039/document.

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L’autophagie est un processus d’autodigestion dans lequel la cellule dégrade ses propres composants dans le but de maintenir l’homéostasie dans ses conditions basales. En absence de nutriments, l’autophagie est activée et favorise la survie cellulaire en fournissant des substrats énergétiques résistant aux conditions de stress. Autophagie et métabolisme communiquent à différents niveaux; une baisse en métabolites richement énergétiques, tels qu’en ATP et en NADH, est détectée par des senseurs cellulaires (AMPK et SIRT1 respectivement) et mène à l’activation de l’autophagie. Ici, nous définisso
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27

Bakkali, Abdelhak. "Contribution à la synthèse de la myricoidine et de la dihydromyricoidine alcaloïdes macrocycliques dérivés de la spermidine." Doctoral thesis, Universite Libre de Bruxelles, 1997. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212238.

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28

Sindi, Kaïs. "Imidates : synthèse de sidérophores pouvant être modifiés par des antibiotiques : étude de leurs propriétés physico-chimiques." Paris 7, 2008. http://www.theses.fr/2008PA077112.

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Une méthode de synthèse d'imidazolides 3a-c, de benzimidazolides 4a-d, et de dérivés 2-substitués d'imidazo-[4,5b]-pyridine 4e-h par condensation de 1,2-diamines 2 sur des imidates N-acylés 1 est décrite et illustrée par une dizaine d'exemples (Chap. I). Dans le chapitre II, la synthèse de conjugués sidérophore-antibiotique est envisagée selon deux stratégies à partir d'une aminé secondaire 13 dérivée de la spermidine 5 et de l'acide 2,3-dihydroxybenzoïque 7. Deux stratégies de synthèse ont été développées. La première consiste à modifier l'aminé secondaire 13 par un espaceur en C3 ou C5 prése
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29

Seguineau, Menanteau Corinne. "Caracterisation et approche synthetique de macrocycles spermidiniques isoles d'une celastraceae neo-caledonienne : pleurostylia apposita (wallich) alston." Angers, 1995. http://www.theses.fr/1995ANGE0501.

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30

Bergeron, Christophe. "Les polyamines : agents diagnostiques et cibles thérapeutiques en oncologie pédiatrique." Rennes 1, 1993. http://www.theses.fr/1993REN1B006.

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31

Bertin, Aurélie. "Compréhension des mécanismes électrostatiques impliqués dans la plasticité structurale de la chromatine eucaryote." Paris 11, 2006. http://www.theses.fr/2006PA114813.

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Nous avons montré que les queues d'histones H3 et H4 sont nécessaires pour que des interactions attractives s'établissent entre NCPs, en présence d'ions monovalents. Pour cela, nous avons comparé des NCPs recombinantes intactes et gH3gH4 (sans queues H3 et H4) par SAXS. Les données expérimentales ont été comparées à des simulations établies à partir d'un modèle simple de potentiel d'interaction de paires. Les interactions entre NCPs gH3gH4 sont décrites par un potentiel de type répulsif uniquement. Par contre, l'introduction d'une composante attractive dans le potentiel est indispensable pour
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32

Ariyaratne, Menaka M. "A new perspective on polyamine biosynthesis and transport in arabidopsis thaliana." Bowling Green State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1555693507751475.

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33

Vargas, Ashley Joy. "Assessing the Role of Dietary Polyamines on the Continuum of Colorectal Carcinoma." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/293416.

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Putrescine, spermidine and spermine are the polyamines biosynthesized by human cells via ornithine decarboxylase (ODC) and are also sourced from the diet. Polyamines are required for malignant and normal cell growth and development. Pharmacological suppression of polyamine biosynthesis, by difluoromethylornithine, and inflammation, via sulindac, has demonstrated ~70% efficacy in preventing premalignant colorectal adenomas (CRA) in a clinical trial; however, high polyamine intakes mitigated this preventative action. Further, dietary polyamines increase the dysplasia of CRA in initiated animal m
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34

Searles, Lynne E. (Lynne Elizabeth). "Effects of orally administered spermidine on absorptive enzyme and nutrient transporter gene expression in the rat small intestine during postnatal development." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23298.

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The developmental profiles of mRNA and protein expression for ornithine decarboxylase (ODC), the Na$ sp+$-dependent glucose co-transporter (SGLT1), sucrase isomaltase (SI), and the Na$ rm sp+K sp+$ ATPase $ alpha sb1$ and $ beta sb1$ subunit isoforms in the postnatal rat small intestine, as well as the effects of exogenous spermidine on their precocious development, were examined. Postnatal age had a significant effect with all enzymes and the nutrient transporter maturing around weaning. Consecutive exposure to exogenous spermidine during suckling precociously induced ODC mRNA, SI protein, an
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Bauer, Julia [Verfasser], and Florian [Akademischer Betreuer] Lang. "Der suizidale Zelltod humaner Erythrozyten - Stimulation durch Sphingosin und Auswirkungen der biogenen Polyamine Spermin und Spermidin / Julia Bauer ; Betreuer: Florian Lang." Tübingen : Universitätsbibliothek Tübingen, 2013. http://d-nb.info/1160754489/34.

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36

Zhang, Hanlin. "Translational control of autophagy rejuvenates immune responses." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:9950cef9-7592-41b4-973c-c906edad23c8.

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As our body's guardian, the immune system maintains systemic health through removal of pathogens, damage and cancer. Ageing of the immune system is associated with compromised immune responses as well as decreased tumour surveillance and is therefore a key risk factor for major diseases in the elderly. Adaptive immune responses are mediated by T and B lymphocytes, and failure in adaptive immunity is a particular hallmark of the ageing organism. Here we show that autophagy is impaired in aged murine B lymphocytes, and loss of autophagy causes severely reduced B cell responses. Our data demonstr
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Fredericks, Eugene B. (Eugene Bernard). ""Studies involving alterations of polyamine metabolism in Arabidopsis thaliana"." Monash University, Dept. of Biological Sciences, 2001. http://arrow.monash.edu.au/hdl/1959.1/8432.

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Vaishali, Mulangi Gopala Reddy. "Characterization of Polyamine Transporters from Rice and Arabidopsis." Bowling Green State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1303231265.

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Chrisam, Martina. "Novel insights into the role of skeletal muscle autophagy in health and disease." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424327.

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Structurally or functionally altered and unnecessary cellular components are physiologically removed from the cell through a self-degradative process named autophagy. An impairment of the autophagic machinery was shown to have a central role in the pathogenesis of several neurodegenerative, cardiac and age-related diseases. In the laboratory of Prof. Paolo Bonaldo, it was previously shown that an impairment of the autophagy pathway plays a key role in the pathogenesis of Bethlem Myopathy (BM) and Ullrich Congenital Muscular Dystrophy (UD), inherited human pathologies associated to collagen VI
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40

Rioux, Benjamin. "Synthèse et vectorisation de biomolécules type Chalcone en vue d'une application anticancéreuse." Thesis, Limoges, 2016. http://www.theses.fr/2016LIMO0104/document.

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La synthèse et la vectorisation d’agents anticancéreux constituent des axes de recherche majeurs du LCSN. De nombreux composés naturels possèdent des propriétés anticancéreuses, mais ils sont abandonnés en raison de leur manque de sélectivité vis-à-vis des cellules cancéreuses ou de leur faible biodisponibilité. Ainsi, un grand intérêt est actuellement porté sur le développement de médicaments spécifiquement vectorisés vers les cellules cancéreuses. Les vecteurs utilisés dans ce travail sont des dérivés de polyamines et des nano objets de type β-cyclodextrines / nanocristaux de cellulose (β-CD
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AUBEL, CORINNE. "Effet d'une carence en acide amine sur deux mecanismes majeurs de l'homeostasie des polyamines : le transport membranaire et le catabolisme par la spermidine/spermine n1-acetyltransferase (doctorat)." Clermont-Ferrand 1, 2001. http://www.theses.fr/2001CLF1MM13.

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42

Schopis, Jia L. "Drug Discovery Studies of the T box Riboswitch: Potential Ligand Inhibition andCofactor Modulation of the tRNA-Antiterminator Complex Recognition." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1461674214.

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43

Chiteri, Kevin Oyale. "Functional & Phylogenetic Analysis of Arabidopsis thaliana Organic Cation Transporters (OCT5 & OCT1) Genes in Polyamine Transport in Plants." Bowling Green State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1563038129138996.

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44

Ménard, Florian. "Benzoporphyrines polyaminées et glycolisées : synthèses et tests biologiques." Limoges, 2008. https://aurore.unilim.fr/theses/nxfile/default/8fa60a2e-636b-4c5d-b022-4d474de42c60/blobholder:0/2008LIMO4065.pdf.

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Ce travail porte sur la synthèse multi-étapes, la caractérisation et l'évaluation biologique de nouveaux photosensibilisateurs vectorisés conçus pour une utilisation potentielle en photothérapie dynamique des cancers. Nous avons élaboré plusieurs tétrabenzoporphyrines symétriques substituées par quatre polyamines ou quatre molécules de glucose, dans le but d’augmenter leur sélectivité pour les cellules cancéreuses. Ces dérivés de benzoporphyrines ont été obtenus suivant deux approches distinctes. Ainsi, la fixation des vecteurs (spermidine, spermine, α-D-glucose ou β-D-glucose) a été effectuée
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45

Martignoni, Felipe Villa. "TRAXOPRODIL ATENUA AS CONVULSÕES INDUZIDAS POR PENTILENOTETRAZOL." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/8951.

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There is evidence that while polyamines facilitate seizures by positively modulating N-methyl-D-aspartate receptors (NMDAr), selective antagonists of the NR2B-subunit decrease seizures. However, it remains undetermined whether traxoprodil (CP-101,606), an ifenprodil analog that acts as a selective antagonist of the NR2B subunit of the NMDAr, decreases seizure activity. In the current study we investigated whether traxoprodil alters PTZ-induced seizures in adult male Wistar rats by behavioral and electroencephalographical methods. Spermidine (SPD) (2 nmol/site; i.c.v.) facilitated behavioral an
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Ceretta, Ana Paula Chiapinotto. "Administração sistêmica de espermidina e arcaína altera a memória da tarefa de esquiva inibitória em ratos: envolvimento da dependência de estado." Universidade Federal de Santa Maria, 2006. http://repositorio.ufsm.br/handle/1/11145.

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The polyamines, putrescine, spermidine and spermine, are present in high concentrations in the central nervous system and, because of their policationic nature, they can interact with diverse cellular anionic targets (nucleic acids and proteins) and modulate the learning and memory by interacting with the polyamine binding site at N-methyl-D-aspartate receptor. In this study we investigated the effects of the systemic administration of spermidine and arcaine on the memory of the inhibitory avoidance task in rats. It was also determined whether the effects of the spermidine and arcaine involve
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47

Tomazi, Lediane. "ARCAÍNA REVERTE A PREFERÊNCIA CONDICIONADA POR LUGAR INDUZIDA POR MORFINA EM CAMUNDONGOS." Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/9019.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The morphine addiction is a chronic disease that involves biological, cognitive and behavioral changes developed after repeated and compulsive drug use. Even after long periods of abstinence relapses occur to users, especially when faced with situations that resemble the use thereof. The protocol of conditioned place preference (CPP) has been one of the most widely used experimental models to measure the positive reinforcing effects (conditioned place preference) and negative (conditioned place aversion) of several drugs, includi
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Gomes, Guilherme Monteiro. "Agentes poliaminérgicos modulam a extinção do medo condicionado contextual em ratos." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/11118.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Polyamines, such as spermidine and spermine, have been reported to improve memory retention through the activation of N-methyl-D-aspartate receptors (NMDAr). However whether polyamine agonists and antagonists alter extinction remains unclear. In the current study, we investigated whether spermidine and polyamine antagonists that selectively block the NR2B subunit at the NMDAr alter the extinction of contextual conditioned fear in male Wistar rats. While the bilateral intrahippocampal administration of exogenous spermidine (2 nmol
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Zeng, Chunxi. "Riboswitch-targeted Drug Discovery: Investigation of Factors that Affect the T Box Transcription Antitermination Mechanism." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1451943674.

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Ribeiro, Daniela Aymone. "AGENTES POLIAMINÉRGICOS MODULAM A RECONSOLIDAÇÃO DA MEMÓRIA DE MEDO EM RATOS." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/11216.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The memory may be studied according with memory's phases, which is acquisition, consolidation and recall. Memories once consolidated, are no more susceptible to interventions, but when reactivated, some of these memories again become labile and vulnerable, and to persist need to have a new stabilization process called reconsolidation. Previous studies described that endogenous polyamines, spermine and spermidine, which bind and modulate the activity of NMDA receptors are involved in memory acquisition and consolidation. However the
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