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Journal articles on the topic 'Spheroidal degeneration'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Elhusseiny, AM. "Advanced spheroidal degeneration." Digital Journal of Ophthalmology 25, no. 4 (2019): 68. http://dx.doi.org/10.5693/djo.02.2019.11.001.

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Magovern, Malcolm, John D. Wright,, and Andrew Mohammed. "Spheroidal Degeneration of the Cornea." Cornea 23, no. 1 (2004): 84–88. http://dx.doi.org/10.1097/00003226-200401000-00015.

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Dinç, Erdem, Ufuk Adıgüzel, Bahri Aydın, İdil Göksel, and Özlem Yıldırım. "Spheroidal Degeneration of the Cornea." Türk Oftalmoloji Dergisi 41, no. 4 (2011): 264–66. http://dx.doi.org/10.4274/tjo.41.44154.

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Lacaze, J. "On the role of interfacial segregation on graphite shape in cast irons." IOP Conference Series: Materials Science and Engineering 1274, no. 1 (2023): 012039. http://dx.doi.org/10.1088/1757-899x/1274/1/012039.

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Abstract Understanding spheroidal graphite growth in cast irons is a long standing problem for which several mechanisms have been proposed. During the last decade, observations using transmission electron microscopy added new information about the stacking of graphite layers, leading eventually to propose other mechanisms than previously thought of such as repeated 2D-nucleation of new growth blocks and their lateral extension at the surface of the spheroids. Furthermore, it has been recently realized that elements known to strongly affect graphite shape are also those that are surface active.

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Madhumita, M., and H. Mohan Kumar. "Association of spheroidal degeneration in pseudoexfoliation cases." Indian Journal of Clinical and Experimental Ophthalmology 5, no. 2 (2019): 186–89. http://dx.doi.org/10.18231/j.idjsr.2019.044.

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6

Madhumita, M., and H. Mohan Kumar. "Association of spheroidal degeneration in pseudoexfoliation cases." Indian Journal of Clinical and Experimental Ophthalmology 5, no. 2 (2019): 186–89. http://dx.doi.org/10.18231/j.ijceo.2019.044.

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7

Lai, Kevin, Jason Reidy, Benjamin Bert, and Tatyana Milman. "Spheroidal Degeneration in H626R TGFBI Variant Lattice Dystrophy." Cornea 33, no. 7 (2014): 726–32. http://dx.doi.org/10.1097/ico.0000000000000140.

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8

Yabanoğlu, Demet, Mehmet Cem Mocan, Murat İrkeç, Mehmet Orhan, Figen Söylemezoğlu, and Özlem Tanas Işıkcı. "Spheroidal Degeneration in Two Siblings: Clinical and Histopathological Features." Turkish Journal of Ophthalmology 51, no. 4 (2021): 246–49. http://dx.doi.org/10.4274/tjo.galenos.2021.59558.

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Ota, Shoichiro, Takayuki Tanaka, and Susumu Ishida. "A case of conjunctival intraepithelial neoplasia with spheroidal degeneration: a clinicopathological study." International Journal of Ophthalmology 15, no. 8 (2022): 1401–3. http://dx.doi.org/10.18240/ijo.2022.08.25.

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Baer, Wolfram. "Chunky Graphite in Ferritic Spheroidal Graphite Cast Iron: Formation, Prevention, Characterization, Impact on Properties: An Overview." International Journal of Metalcasting 14, no. 2 (2019): 454–88. http://dx.doi.org/10.1007/s40962-019-00363-8.

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Abstract Ferritic spheroidal graphite cast iron (SGI) materials have a remarkable technical potential and economic impact in modern industry. These features are closely related to the question of how the cast materials can be produced without structural defects and graphite degenerations such as, for example, chunky graphite. Although the chunky graphite degeneration superficially seems to be well known, its metallurgical background is still controversially discussed, appropriate field-tested nondestructive tools for its quantification in castings are lacking, and the knowledge on its impact o

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Hida, T., K. Kigasawa, E. Tanaka, S. Akiya, Y. Tashiro, and Y. Hosoda. "Primary band-shaped spheroidal degeneration of the cornea: three cases from two consanguineous families." British Journal of Ophthalmology 70, no. 5 (1986): 347–53. http://dx.doi.org/10.1136/bjo.70.5.347.

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12

Stefanescu, Doru M., Gorka Alonso, and Ramon Suarez. "Recent Developments in Understanding Nucleation and Crystallization of Spheroidal Graphite in Iron-Carbon-Silicon Alloys." Metals 10, no. 2 (2020): 221. http://dx.doi.org/10.3390/met10020221.

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The last decade has witnessed significant research efforts directed to the understanding of nucleation and crystallization of graphite and associated solidification phenomena, driven in part by the ever-growing interest in the use of spheroidal graphite cast iron in the manufacture of large castings, such as wind turbine parts. These applications raised new challenges to the production of sound castings, mostly because of the exceedingly long solidification times imposed by the size of the castings. These solidification conditions resulted in many instances in graphite degeneration with subseq

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Mohan, Amit, Zeeshan Jamil, VishalC Bhatanagar, and Manju Gajraj. "Prevalence of spheroidal degeneration of cornea and its association with other eye diseases in tribes of Western Rajasthan." Indian Journal of Ophthalmology 65, no. 10 (2017): 1010. http://dx.doi.org/10.4103/ijo.ijo_84_17.

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14

Benedetti, Matteo, Vigilio Fontanari, and Danilo Lusuardi. "Fatigue and fracture resistance of ferritic ductile cast iron: the effect of Sb and solidification time." MATEC Web of Conferences 165 (2018): 13011. http://dx.doi.org/10.1051/matecconf/201816513011.

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In this paper, we explore the effect of inoculants and solidification time on the mechanical properties of an EN-GJS-400-type ferritic ductile cast iron (DCI). For this purpose, static tensile, rotating bending fatigue, fatigue crack growth and fracture toughness tests are carried out on three different material conditions. They are produced under fast cooling (solidification time 2h45min), representative of thin walled castings, and very slow cooling (solidification time 10—13h), representative of thick walled castings, this latter with and without the addition of Sb. It has been found that t

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Akiya, Shinobu, Hiroshi Takahashi, Hiroshi Furukawa, et al. "A Case of One Eye with Gelatinous Drop-Like Corneal Dystrophy and the Other Eye with Band-Shaped Spheroidal Corneal Degeneration." Ophthalmologica 209, no. 2 (1995): 96–100. http://dx.doi.org/10.1159/000310589.

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16

Tesfay, Kiros, and Menen Ayalew Shibeshi. "Pattern of Spheroidal Degeneration of Cornea and Its Association with Other Eye Diseases at Anterior Segment Clinic in Menelik II Tertiary Referral Hospital." Clinical Ophthalmology Volume 18 (November 2024): 3417–23. http://dx.doi.org/10.2147/opth.s492306.

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17

Kasamkattil, Jesil, Anna Gryadunova, Ivan Martin, et al. "Spheroid-Based Tissue Engineering Strategies for Regeneration of the Intervertebral Disc." International Journal of Molecular Sciences 23, no. 5 (2022): 2530. http://dx.doi.org/10.3390/ijms23052530.

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Degenerative disc disease, a painful pathology of the intervertebral disc (IVD), often causes disability and reduces quality of life. Although regenerative cell-based strategies have shown promise in clinical trials, none have been widely adopted clinically. Recent developments demonstrated that spheroid-based approaches might help overcome challenges associated with cell-based IVD therapies. Spheroids are three-dimensional multicellular aggregates with architecture that enables the cells to differentiate and synthesize endogenous ECM, promotes cell-ECM interactions, enhances adhesion, and pro

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Xie, Lili, Mao Mao, Liang Zhou, Lusi Zhang, and Bing Jiang. "Signal Factors Secreted by 2D and Spheroid Mesenchymal Stem Cells and by Cocultures of Mesenchymal Stem Cells Derived Microvesicles and Retinal Photoreceptor Neurons." Stem Cells International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/2730472.

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We aim to identify levels of signal factors secreted by MSCs cultured in 2D monolayers (2D-MSCs), spheroids (spheroids MSCs), and cocultures of microvesicles (MVs) derived from 2D-MSCs or spheroid MSCs and retinal photoreceptor neurons. We seeded 2D-MSCs, spheroid MSCs, and cells derived from spheroids MSCs at equal numbers. MVs isolated from all 3 culture conditions were incubated with 661W cells. Levels of 51 signal factors in conditioned medium from those cultured conditions were quantified with bead-based assay. We found that IL-8, IL-6, and GROαwere the top three most abundant signal fact

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Venkataramana, Pradeep Addagadde, Rajshekar Rajshekar, and Shruthi Amalagondhi Manjunatha. "Ocular Manifestations of Leprosy Patients on Multidrug Therapy in a Teaching Hospital of South Karnataka." Journal of Evidence Based Medicine and Healthcare 8, no. 21 (2021): 1706–10. http://dx.doi.org/10.18410/jebmh/2021/322.

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BACKGROUND Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae. Several ocular manifestations occur before and during multi drug therapy (MDT) and they can continue to occur even after the completion in bacteriologically cured patients. Blindness is a catastrophic event that can occur by several mechanisms at any stage. We need to learn and recognise the early signs and symptoms of ocular complications, so that we can treat the patient early. We need to evaluate the pattern of ocular manifestation in leprosy patients on MDT (Multi Drug Therapy). METHODS A cross

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20

NORN, MOGENS S. "CONJUNCTIVAL SPHEROID DEGENERATION." Acta Ophthalmologica 60, no. 3 (2009): 434–38. http://dx.doi.org/10.1111/j.1755-3768.1982.tb03035.x.

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21

Ghosh, Amiya K., Toby Hurd, and Friedhelm Hildebrandt. "3D spheroid defects in NPHP knockdown cells are rescued by the somatostatin receptor agonist octreotide." American Journal of Physiology-Renal Physiology 303, no. 8 (2012): F1225—F1229. http://dx.doi.org/10.1152/ajprenal.00135.2012.

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Ciliopathies are a heterogeneous group of diseases that exhibit broad clinical phenotypes, including renal cysts, retinal degeneration, and cerebellar vermis aplasia. Nephronophthisis (NPHP) is a renal ciliopathy that causes chronic kidney disease and is characterized by kidney cysts at the cortico-medullary border. Among the 10 different disease-causing genes ( NPHP1-NPHP10), mutations in NPHP3, NPHP6, or NPHP8 cause the most severe ciliopathy variants of NPHP, Joubert syndrome, and Meckel Syndrome. In this study, we tested the hypothesis that loss of function of these three most severe disea

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22

Schwarz, Gögele, Ondruschka, Hammer, Kohl, and Schulze-Tanzil. "Migrating Myofibroblastic Iliotibial Band-Derived Fibroblasts Represent a Promising Cell Source for Ligament Reconstruction." International Journal of Molecular Sciences 20, no. 8 (2019): 1972. http://dx.doi.org/10.3390/ijms20081972.

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The iliotibial band (ITB) is a suitable scaffold for anterior cruciate ligament (ACL) reconstruction, providing a sufficient mechanical resistance to loading. Hence, ITB-derived fibroblasts attract interest for ligament tissue engineering but have so far not been characterized. This present study aimed at characterizing ITB fibroblasts before, during, and after emigration from cadaveric ITB explants to decipher the emigration behavior and to utilize their migratory capacity for seeding biomaterials. ITB and, for comparison, ACL tissues were assessed for the content of alpha smooth muscle actin

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23

Fuku, Atsushi, Yasuhiko Taki, Yuka Nakamura, et al. "Evaluation of the Usefulness of Human Adipose-Derived Stem Cell Spheroids Formed Using SphereRing® and the Lethal Damage Sensitivity to Synovial Fluid In Vitro." Cells 11, no. 3 (2022): 337. http://dx.doi.org/10.3390/cells11030337.

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Osteoarthritis (OA) is an irreversible degenerative condition causing bone deformation in the joints and articular cartilage degeneration with chronic pain and impaired movement. Adipose-derived stem cell (ADSC) or crushed adipose tissue injection into the joint cavity reportedly improve knee function and symptoms, including pain. Stem cell spheroids may be promising treatment options due to their anti-inflammatory and enhanced tissue regeneration/repair effects. Herein, to form human ADSC spheroids, we used first SphereRing® (Fukoku Co., Ltd., Ageo, Japan), a newly developed rotating donut-sh

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24

JENSEN, O. A., and M. S. NORN. "SPHEROID DEGENERATION OF THE CONJUNCTIVA." Acta Ophthalmologica 60, no. 1 (2009): 79–92. http://dx.doi.org/10.1111/j.1755-3768.1982.tb05784.x.

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25

NORN, M. S. "SPHEROID DEGENERATION OF CORNEA AND CONJUNCTIVA." Acta Ophthalmologica 56, no. 4 (2009): 551–62. http://dx.doi.org/10.1111/j.1755-3768.1978.tb01368.x.

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26

NORN, MOGENS. "SPHEROID DEGENERATION OF CONJUNCTIVA AND CORNEA." Acta Ophthalmologica 58, no. 5 (2009): 805–11. http://dx.doi.org/10.1111/j.1755-3768.1980.tb06694.x.

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27

Bradley, Gregory A., H. Carter Metcalf, Carlos Reggiardo, et al. "Neuroaxonal Degeneration in Sheep Grazing Sorghum Pastures." Journal of Veterinary Diagnostic Investigation 7, no. 2 (1995): 229–36. http://dx.doi.org/10.1177/104063879500700211.

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During the fall of 1992, 250 (10%) of 2,500 Rambouilet cross feeder lambs grazing Sorghum bicolor developed neurologic signs including weakness, ataxia, head shaking, knuckling of the fetlocks, inability to rise, and opisthotonos. One hundred fifteen (46%) of the affected lambs died. Twenty of the surviving lambs exhibited residual neurologic signs of ataxia when stressed. At the same time, 275 (25%) of 1,100 ewes grazing a nearby sudex pasture ( S. sudanese × S. bicolor) gave birth to lambs that were weak and unable to rise. Newborn lambs exhibited extensor rigidity and opisthotonos when assi

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Kikuchi, Tateki. "Circular breakdown of neural networks due to loss of deubiquitinating enzyme (UCH-L1) in gracile axonal dystrophy (<i>gad</i>) mouse." AIMS Molecular Science 8, no. 4 (2021): 311–24. http://dx.doi.org/10.3934/molsci.2021024.

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<abstract> <p>Gracile axonal dystrophy (gad) mouse shows tremor, ataxia and muscular atrophy of hind limbs from about 80-days of age. These clinical features become progressively severe to death. Pathological examination reveals that main and early axonal degeneration exists in a long ascending nervous tract in dorsal column of the spinal cord: gracile nucleus and fascicules. Similar lesions are seen in axonal terminals of peripheral sensory (muscle spindles) and motor endplates. Most striking features of axonal dystrophy are “dying-back” axonal degeneration with partial swellings

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Zhou, L., B. L. Miller, C. H. McDaniel, L. Kelly, O. J. Kim, and C. A. Miller. "Frontotemporal dementia: Neuropil spheroids and presynaptic terminal degeneration." Annals of Neurology 44, no. 1 (1998): 99–109. http://dx.doi.org/10.1002/ana.410440116.

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30

Jeannerat, Annick, Cédric Peneveyre, Sandra Jaccoud, et al. "Banked Primary Progenitor Cells for Allogeneic Intervertebral Disc (IVD) Therapy: Preclinical Qualification and Functional Optimization within a Cell Spheroid Formulation Process." Pharmaceutics 16, no. 10 (2024): 1274. http://dx.doi.org/10.3390/pharmaceutics16101274.

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Background/Objectives: Biological products are emerging as therapeutic management options for intervertebral disc (IVD) degenerative affections and lower back pain. Autologous and allogeneic cell therapy protocols have been clinically implemented for IVD repair. Therein, several manufacturing process design considerations were shown to significantly influence clinical outcomes. The primary objective of this study was to preclinically qualify (chondrogenic potential, safety, resistance to hypoxic and inflammatory stimuli) cryopreserved primary progenitor cells (clinical grade FE002-Disc cells)

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31

Manoussakis, Gerassimos, and Panayiotis Vafeas. "Spherical Harmonics and Gravity Intensity Modeling Related to a Special Class of Triaxial Ellipsoids." Mathematics 13, no. 13 (2025): 2115. https://doi.org/10.3390/math13132115.

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The G-modified Helmholtz equation is a partial differential equation that allows gravity intensity g to be expressed as a series of spherical harmonics, with the radial distance r raised to irrational powers. In this study, we consider a non-rotating triaxial ellipsoid parameterized by the geodetic latitude φ and geodetic longitude λ, and eccentricities ee, ex, ey. On its surface, the value of gravity potential has a constant value, defining a level triaxial ellipsoid. In addition, the gravity intensity is known on the surface, which allows us to formulate a Dirichlet boundary value problem fo

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32

Vong, Chun Kiet, Alan Wang, Mike Dragunow, Thomas I. H. Park, and Vickie Shim. "Robust Quantification of Regional Patterns of Migration in Three-Dimensional Cell Culture Models." Journal of Medical and Biological Engineering 42, no. 1 (2022): 38–48. http://dx.doi.org/10.1007/s40846-022-00680-0.

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Abstract Purpose Wound healing assays is a common two-dimensional migration model, with the spheroid assay three-dimensional migration model recently emerging as being more representative of in vivo migration behaviours. These models provide insight into the overall migration of cells in response to various factors such as biological, chemotactic and molecular agents. However, currently available analysis techniques for these assays fall short on providing quantifiable means to measure regional migration patterns, which is essential to allow a more robust assessment of drug treatments on cell

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33

NORN, MOGENS. "SPHEROID DEGENERATION, KERATOPATHY, PINGUECULA, AND PTERYGIUM IN JAPAN (KYOTO)." Acta Ophthalmologica 62, no. 1 (2009): 54–60. http://dx.doi.org/10.1111/j.1755-3768.1984.tb06756.x.

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Zubillaga, Veronica, Ana Alonso-Varona, Susana C. M. Fernandes, Asier M. Salaberria, and Teodoro Palomares. "Adipose-Derived Mesenchymal Stem Cell Chondrospheroids Cultured in Hypoxia and a 3D Porous Chitosan/Chitin Nanocrystal Scaffold as a Platform for Cartilage Tissue Engineering." International Journal of Molecular Sciences 21, no. 3 (2020): 1004. http://dx.doi.org/10.3390/ijms21031004.

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Articular cartilage degeneration is one of the most common causes of pain and disability in middle-aged and older people. Tissue engineering (TE) has shown great therapeutic promise for this condition. The design of cartilage regeneration constructs must take into account the specific characteristics of the cartilaginous matrix, as well as the avascular nature of cartilage and its cells’ peculiar arrangement in isogenic groups. Keeping these factors in mind, we have designed a 3D porous scaffold based on genipin-crosslinked chitosan/chitin nanocrystals for spheroid chondral differentiation of

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35

Yazawa, Ikuru, Imaharu Nakano, Hiroki Yamada, and Masaya Oda. "Long tract degeneration in familial sudanophilic leukodystrophy with prominent spheroids." Journal of the Neurological Sciences 147, no. 2 (1997): 185–91. http://dx.doi.org/10.1016/s0022-510x(96)05346-4.

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36

Ofosu-Asante, Kweku, Jassy Mary Lazarte, Amarender Burra, and Nazarius S. Lamango. "Abstract 566: The anticancer effects of polyisoprenylated cysteinyl amide inhibitors involves interaction with the KRAS chaperone calmodulin." Cancer Research 84, no. 6_Supplement (2024): 566. http://dx.doi.org/10.1158/1538-7445.am2024-566.

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Abstract Pancreatic cancer is the third leading cause of cancer-related deaths with a 5-year survival rate of less than 10%. Approximately 90% of reported cases are driven by KRAS mutations. The mutant KRAS acquires its functional localization through interactions with chaperone proteins via its polybasic polyisoprenylated tail. Polyisoprenylated cysteinyl amide inhibitors (PCAIs) mimic this region possibly disrupting the polyisoprenylation-dependent interactions with chaperone proteins. Here, we determine the effect of newly developed PCAIs that were designed to be more water-soluble on cell

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37

Beirowski, Bogdan, Antal Nógrádi, Elisabetta Babetto, Guillermo Garcia-Alias, and Michael P. Coleman. "Mechanisms of Axonal Spheroid Formation in Central Nervous System Wallerian Degeneration." Journal of Neuropathology & Experimental Neurology 69, no. 5 (2010): 455–72. http://dx.doi.org/10.1097/nen.0b013e3181da84db.

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38

Castellanos-Montiel, María José, Mathilde Chaineau, Anna Kristyna Franco-Flores, et al. "An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids." Cells 12, no. 4 (2023): 545. http://dx.doi.org/10.3390/cells12040545.

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A multitude of in vitro models based on induced pluripotent stem cell (iPSC)-derived motor neurons (MNs) have been developed to investigate the underlying causes of selective MN degeneration in motor neuron diseases (MNDs). For instance, spheroids are simple 3D models that have the potential to be generated in large numbers that can be used across different assays. In this study, we generated MN spheroids and developed a workflow to analyze them. To start, the morphological profiling of the spheroids was achieved by developing a pipeline to obtain measurements of their size and shape. Next, we

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39

Kwon, Hee Jung, Duk L. Na, Hee Jin Kim, and Yeon-Lim Suh. "Adult-Onset Leukoencephalopathy with Axonal Spheroid and Pigmented Glia: Different Histological Spectrums Presented in Autopsy Cases of Siblings and a Surgical Case of Stereotactic Biopsy." Diagnostics 13, no. 6 (2023): 1018. http://dx.doi.org/10.3390/diagnostics13061018.

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Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia encompasses hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented orthochromatic leukodystrophy. We describe the clinicopathological and genetic findings of three patients with this disorder. All patients presented with dysarthria, with or without cognitive decline. The first and second patients were siblings who died of the disease at ages 42 and 54, respectively, while the third patient has been bedridden. Brain magnetic resonance imaging revealed T2 hyperintensities in the subcortical and periventr

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Brüll, Markus, Nils Geese, Ivana Celardo, Michael Laumann, and Marcel Leist. "Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies." Cells 13, no. 3 (2024): 242. http://dx.doi.org/10.3390/cells13030242.

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Few models allow the study of neurite damage in the human central nervous system. We used here dopaminergic LUHMES neurons to establish a culture system that allows for (i) the observation of highly enriched neurites, (ii) the preparation of the neurite fraction for biochemical studies, and (iii) the measurement of neurite markers and metabolites after axotomy. LUHMES-based spheroids, plated in culture dishes, extended neurites of several thousand µm length, while all somata remained aggregated. These cultures allowed an easy microscopic observation of live or fixed neurites. Neurite-only cult

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Yong, Yu, Kanchana Gamage, Irene Cheng, et al. "p75NTR and DR6 Regulate Distinct Phases of Axon Degeneration Demarcated by Spheroid Rupture." Journal of Neuroscience 39, no. 48 (2019): 9503–20. http://dx.doi.org/10.1523/jneurosci.1867-19.2019.

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42

NORN, MOGENS S. "SPHEROID DEGENERATION, PINGUECULA, AND PTERYGIUM AMONG ARABS IN THE RED SEA TERRITORY, JORDAN." Acta Ophthalmologica 60, no. 6 (2009): 949–54. http://dx.doi.org/10.1111/j.1755-3768.1982.tb00626.x.

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Novikova, V. D., L. E. Agafonova, G. E. Leonov, et al. "Electrochemical sensor for assessing the accumulation of extracellular matrix in cultured chondrospheres." Uchenye Zapiski Kazanskogo Universiteta Seriya Estestvennye Nauki 167, no. 2 (2025): 185–200. https://doi.org/10.26907/2542-064x.2025.2.185-200.

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The degeneration of cartilage in articular joints is a significant medical concern due to its high incidence rate. Damaged articular cartilage has a limited ability to regenerate naturally and thus often requires regenerative therapy. Intra-articular matrix-associated autologous chondrocyte transplantation, which involves the introduction of chondrocytes into the damaged area either as part of tissue-engineered constructs with a carrier matrix (scaffold) or in the form of tissue spheroids (chondrospheres), is generally considered the gold standard for treating such defects. This approach is pr

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44

De Paula, A. Maues, B. Michel, D. W. Dickson, Z. K. Wszolek, and J. F. Pellissier. "Sporadic diffuse leucoencephalopathy with axonal spheroids: report of a profuse and rapid cortical–spinal degeneration." Neurological Sciences 33, no. 4 (2011): 905–9. http://dx.doi.org/10.1007/s10072-011-0817-8.

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45

Hwang, Sean, Jangwan Ha, Min Young Choi, et al. "Hereditary Diffuse Leukoencephalopathy with Axonal Spheroids Mistaken for Stroke: A Case Report." Journal of the Korean Neurological Association 40, no. 4 (2022): 322–26. http://dx.doi.org/10.17340/jkna.2022.4.7.

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Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) is a rare autosomal dominant disorder that is caused by colony stimulating factor 1 receptor gene mutation degenerating the cerebral white matter. It is characterized by various symptoms such as progressive cognitive decline, personality changes, and motor disorders. Since these clinical features are not consistent, HDLS is often underdiagnosed or misdiagnosed. This case report presents a patient priorly diagnosed with cerebral infarction by clinical features, but eventually with HDLS by a genetic test.

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Robertson, Janice, Mohammad M. Doroudchi, Minh Dang Nguyen, et al. "A neurotoxic peripherin splice variant in a mouse model of ALS." Journal of Cell Biology 160, no. 6 (2003): 939–49. http://dx.doi.org/10.1083/jcb.200205027.

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Peripherin, a neuronal intermediate filament (nIF) protein found associated with pathological aggregates in motor neurons of patients with amyotrophic lateral sclerosis (ALS) and of transgenic mice overexpressing mutant superoxide dismutase-1 (SOD1G37R), induces the selective degeneration of motor neurons when overexpressed in transgenic mice. Mouse peripherin is unique compared with other nIF proteins in that three peripherin isoforms are generated by alternative splicing. Here, the properties of the peripherin splice variants Per 58, Per 56, and Per 61 have been investigated in transfected c

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Mi, W. "The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice." Brain 128, no. 2 (2004): 405–16. http://dx.doi.org/10.1093/brain/awh368.

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Robertson, Janice, Jean-Martin Beaulieu, Mohammad M. Doroudchi, Heather D. Durham, Jean-Pierre Julien та Walter E. Mushynski. "Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-α". Journal of Cell Biology 155, № 2 (2001): 217–26. http://dx.doi.org/10.1083/jcb.200107058.

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Abstract:

Peripherin, a neuronal intermediate filament protein associated with axonal spheroids in amyotrophic lateral sclerosis (ALS), induces the selective degeneration of motor neurons when overexpressed in transgenic mice. To further clarify the selectivity and mechanism of peripherin-induced neuronal death, we analyzed the effects of peripherin overexpression in primary neuronal cultures. Peripherin overexpression led to the formation of cytoplasmic protein aggregates and caused the death not only of motor neurons, but also of dorsal root ganglion (DRG) neurons that were cultured from dissociated s

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Marin, Raul E., Juan F. Micheloud, Nilda D. Vignale, et al. "Intoxication by Astragalus garbancillo var. garbancillo in llamas." Journal of Veterinary Diagnostic Investigation 32, no. 3 (2020): 467–70. http://dx.doi.org/10.1177/1040638720914338.

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Abstract:

Lysosomal storage diseases are inherited and acquired disorders characterized by dysfunctional lysosomes. Intracytoplasmic accumulation of undegraded substrates leads to impaired cellular function and death. Several plant species are toxic to livestock because of the presence of indolizidine alkaloids, including swainsonine, which cause a storage disease. Swainsonine-induced nervous disease (i.e., locoism) of sheep and cattle is well recognized in several parts of the world, particularly in the western United States and in parts of Australia. Spontaneous intoxication by Astragalus garbancillo

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NORN, M. S. "PREVALENCE OF PINGUECULA IN GREENLAND AND IN COPENHAGEN, AND ITS RELATION TO PTERYGIUM AND SPHEROID DEGENERATION." Acta Ophthalmologica 57, no. 1 (2009): 96–105. http://dx.doi.org/10.1111/j.1755-3768.1979.tb06664.x.

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