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Journal articles on the topic 'Spheroidal drop'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Zabarankin, Michael, Irina Smagin, Olga M. Lavrenteva, and Avinoam Nir. "Viscous drop in compressional Stokes flow." Journal of Fluid Mechanics 720 (February 27, 2013): 169–91. http://dx.doi.org/10.1017/jfm.2013.6.

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AbstractThe dynamics of the deformation of a drop in axisymmetric compressional viscous flow is addressed through analytical and numerical analyses for a variety of capillary numbers, $\mathit{Ca}$, and viscosity ratios, $\lambda $. For low $Ca$, the drop is approximated by an oblate spheroid, and an analytical solution is obtained in terms of spheroidal harmonics; whereas, for the case of equal viscosities ($\lambda = 1$), the velocity field within and outside a drop of a given shape admits an integral representation, and steady shapes are found in the form of Chebyshev series. For arbitrary

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2

Abu Hassan, Nurul Nadiya, Mastura Ab Wahid, Shafaruniza Mahadi, Farah Suraya Md Nasrudin, and Junarti Junarti. "Mass Transfer Model for Prolate Spheroidal Drop in RDC Column." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 129, no. 2 (2025): 1–12. https://doi.org/10.37934/arfmts.129.2.112.

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This study investigates mass transfer involving a prolate spheroidal drop, focusing on molecular diffusion within a stagnant medium. Traditional models often consider spherical drops, but this research introduces a new model based on the prolate spheroidal shape to account for variations influenced by internal circulation currents. Using the finite difference method (FDM), we solve the initial boundary value problem (IBVP) derived from Fick’s second law of diffusion, transformed into prolate spheroidal coordinates. The study demonstrates how the shape and size of prolate spheroidal drops affec

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3

Amokrane, H., and B. Caussade. "Gas Absorption into a Moving Spheroidal Water Drop." Journal of the Atmospheric Sciences 56, no. 12 (1999): 1808–29. http://dx.doi.org/10.1175/1520-0469(1999)056<1808:gaiams>2.0.co;2.

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4

Shiryaeva, S. O., D. O. Kornienko, and M. V. Volkova. "On the electrostatic stability of a charged spheroidal drop." Surface Engineering and Applied Electrochemistry 45, no. 4 (2009): 272–79. http://dx.doi.org/10.3103/s1068375509040048.

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5

Zabarankin, Michael. "Analytical Solution for Spheroidal Drop under Axisymmetric Linearized Boundary Conditions." SIAM Journal on Applied Mathematics 76, no. 4 (2016): 1606–32. http://dx.doi.org/10.1137/15m1048471.

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6

DUBASH, N., and A. J. MESTEL. "Behaviour of a conducting drop in a highly viscous fluid subject to an electric field." Journal of Fluid Mechanics 581 (May 22, 2007): 469–93. http://dx.doi.org/10.1017/s0022112007006040.

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We consider the slow deformation of a relatively inviscid conducting drop surrounded by a viscous insulating fluid subject to a uniform electric field. The general behaviour is to deform and elongate in the direction of the field. Detailed numerical computations, based on a boundary integral formulation, are presented. For fields below a critical value, we obtain the evolution of the drop to an equilibrium shape; above the critical value, we calculate the drop evolution up to breakup. At breakup it appears that smaller droplets are emitted from the ends of the drop with a charge greater than t

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7

POENARU, D. N., R. A. GHERGHESCU, and W. GREINER. "STABLE SPHEROIDAL CAP SHAPES OF DEPOSITED ATOMIC CLUSTERS." International Journal of Modern Physics B 24, no. 17 (2010): 3411–23. http://dx.doi.org/10.1142/s0217979210055743.

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Neutral short and long spheroidal cap clusters have been investigated within the liquid drop model. Analytical results have been obtained for the deformation-dependent surface and curvature energies. A large variety of experimentally determined shapes (both oblate and prolate) are explained by simulating the interaction energy with the substrate with a modified surface tension of the base, and by changing the missing or extended height of the cap, d. The results are illustrated for Na 56 and Na 148 atomic clusters.

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8

Shiryaeva, S. O., A. I. Grigor’ev, and D. O. Kornienko. "Mechanisms behind spheroidal oscillations and electrostatic instability of a charged drop." Technical Physics 55, no. 11 (2010): 1558–68. http://dx.doi.org/10.1134/s1063784210110034.

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9

Poenaru, D. N., R. A. Gherghescu, A. V. Solov'yov, and W. Greiner. "Liquid-drop stability of a superdeformed prolate semi-spheroidal atomic cluster." Europhysics Letters (EPL) 79, no. 6 (2007): 63001. http://dx.doi.org/10.1209/0295-5075/79/63001.

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10

Grigor’ev, A. I., and S. O. Shiryaeva. "Critical conditions for instability of a highly charged oblate spheroidal drop." Technical Physics 44, no. 7 (1999): 745–49. http://dx.doi.org/10.1134/1.1259340.

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11

Shiryaeva, S. O. "Oscillations of a viscous spheroidal drop with allowance for capillary forces." Oceanographic Literature Review 45, no. 1 (1998): 188–89. https://doi.org/10.1016/s0967-0653(98)80941-1.

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12

Simpson, Harry J., and Philip L. Marston. "Lips caustics in light backscattered from an acoustically levitated spheroidal water drop." Journal of the Acoustical Society of America 86, S1 (1989): S5. http://dx.doi.org/10.1121/1.2027571.

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13

Tonini, S., and G. E. Cossali. "Modeling the evaporation of multicomponent drops of general shape on the basis of an analytical solution to the Stefan–Maxwell equations." Physics of Fluids 34, no. 7 (2022): 073313. http://dx.doi.org/10.1063/5.0098937.

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This paper proposes an analytical approach to model the evaporation of multicomponent drops of general shape, which is based on the solution to Stefan–Maxwell equations. The model predicts the quasi-steady molar fractions and temperature distributions in the gas phase as well as the heat rate and the species evaporation rates. The model unifies previous approaches to this problem, namely, for spherical and spheroidal drops, under a unique model and proposes solutions for other shapes and geometries, such as sessile drops and drop pairs. To assess the model, a comparison with a numerical soluti

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14

Jog, M. A., and M. A. Hader. "Transient heat transfer to a spheroidal liquid drop suspended in an electric field." International Journal of Heat and Fluid Flow 18, no. 4 (1997): 411–18. http://dx.doi.org/10.1016/s0142-727x(97)00007-6.

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15

Armandoost, Parisa, Morteza Bayareh, and Afshin Ahmadi Nadooshan. "Study of the motion of a spheroidal drop in a linear shear flow." Journal of Mechanical Science and Technology 32, no. 5 (2018): 2059–67. http://dx.doi.org/10.1007/s12206-018-0415-2.

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16

Ширяев, С.О., А.И. Григорьев та Н.Ю. Колбнева. "Асимптотический анализ электромагнитного излучения незаряженной сфероидальной капли, осциллирующей в электростатическом поле". Elektronnaya Obrabotka Materialov 53, № 3 (2017): 33–40. https://doi.org/10.5281/zenodo.1053519.

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The oscillations of an uncharged spheroidal drop of a conducting liquid in a uniform electrostatic field are considered. It is shown that the oscillations of the centers of inducting charges of different signs connected with the surface oscillation lead to the radiation of electromagnetic waves of the dipole type. A mathematical model of the electromagnetic radiation is constructed and an assessment of its intensity depending on the size of a drop and on the external field strength is carried out. Рассмотрены осцилляции незаряженной сфероидальной капли проводящей жидкости в однородном электрос

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17

Eugene, Musongong. "Rain Drop Contraction in the Gravitational Field of a Stationary Homogeneous Prolate Spheroidal Body." Journal of Applied Sciences 7, no. 21 (2007): 3330–33. http://dx.doi.org/10.3923/jas.2007.3330.3333.

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18

Grigor’ev, A. I., N. Yu Kolbneva, and S. O. Shiryaeva. "Radiation of electromagneticwaves by a spheroidal charged drop oscillating in a uniform electrostatic field." Fluid Dynamics 51, no. 3 (2016): 434–42. http://dx.doi.org/10.1134/s0015462816030157.

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19

Zabarankin, Michael. "A Liquid Spheroidal Drop in a Viscous Incompressible Fluid under a Steady Electric Field." SIAM Journal on Applied Mathematics 73, no. 2 (2013): 677–99. http://dx.doi.org/10.1137/120888430.

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20

Shiryaeva, S. O. "Influence of charge relaxation on the capillary oscillations of a charged viscous spheroidal drop." Technical Physics 44, no. 8 (1999): 894–902. http://dx.doi.org/10.1134/1.1259401.

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21

Shchukin, S. I., and A. I. Grigor’ev. "Local enhancement of a uniform electrostatic field near the tip of a spheroidal drop." Technical Physics 44, no. 8 (1999): 913–17. http://dx.doi.org/10.1134/1.1259404.

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22

Колбнева, Н.Ю., С.О. Ширяева та Ю.Б. Кузьмичев. "О величине индуцированных зарядов и электростатического диполя вытянутого проводящего сфероида, расположенного коллинеарно однородному электростатическому полю". Elektronnaya Obrabotka Materialov 53, № 1 (2017): 9–15. https://doi.org/10.5281/zenodo.1048818.

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Аналитическим путем в сферической системе координат переходом от сфероидальных координат в линейном приближении по квадрату эксцентриситета найдены величина и положения центров индуцированных зарядов и величина поляризационного диполя. By analytical way, in a spherical system of coordinates, transition from spheroidal coordinates in a linear approach on a square of eccentricity sizes and provisions of the centers of the induced charges and dipole size were found

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23

BASTRUKOV, S. I. "SURFACE VIBRATIONS OF STRATIFIED NEUTRON STAR IN THE NEWTONIAN LIMIT OF GRAVITY." International Journal of Modern Physics D 05, no. 01 (1996): 45–51. http://dx.doi.org/10.1142/s0218271896000059.

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From theoretical analysis of the radial distribution of bulk density in the neutron star interior it follows that a neutron star is a strongly stratified compact stellar object with a rather complicated layering structure: the density of outer layers (crust, neutron-rich nuclei, electrons) is much less than the density of the inner region of the stiff core (dense matter of superfluid neutrons, superconducting protons). Simplifying this picture we study the surface vibrations of a nonrotating neutron star in the model of a rigid-like inert core covered by the dynamical liquid-like layer; the ef

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24

Shchukin, S. I., and A. I. Grigor’ev. "Critical equilibrium spheroidal deformation of a drop of dielectric liquid in a uniform electrostatic field." Technical Physics 44, no. 7 (1999): 758–62. http://dx.doi.org/10.1134/1.1259342.

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25

Koromyslov, V. A., Yu D. Rakhmanova, and S. O. Shiryaeva. "Influence of spheroidal deformation on the stability of a drop charged below the Rayleigh limit." Technical Physics Letters 23, no. 7 (1997): 553–54. http://dx.doi.org/10.1134/1.1261892.

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26

Chashechkin, Yu D. "Packets of Capillary and Acoustic Waves of Drop Impact." Herald of the Bauman Moscow State Technical University. Series Natural Sciences, no. 1 (94) (February 2021): 73–91. http://dx.doi.org/10.18698/1812-3368-2021-1-73-91.

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Flows, capillary waves, and acoustic signals generated by a drop of water falling into a pool of degassed liquid were recorded by a high-speed video camera, hydro-phone, and microphone. A large-scale analysis of the system of equations was performed. The fast conversion of available surface potential energy is traced. The converted energy is stored in a thin layer in the vicinity of the merged free surfaces and creates large perturbations of temperature, pressure and flow velocity. Capillary waves start to radiate simultaneously with the formation of a cavity and the rise of the crown. New gro

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27

Inada, S., and W. J. Yang. "Effects of Heating Surface Materials on a Liquid–Solid Contact State in a Sessile Drop-Boiling System." Journal of Heat Transfer 115, no. 1 (1993): 222–30. http://dx.doi.org/10.1115/1.2910652.

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Three experimental investigations are performed on the liquid–solid contact state at the instant when a liquid comes in contact with a heating surface in the transition-boiling regime between the maximum evaporation rate point and the spheroidal state: (1) measuring the piezoelectric potential by means of a quartz oscillator being placed on the heating surface, (2) monitoring the boiling sound generated at the instant of liquid–solid contact using a condenser microphone, and (3) observation of drop behavior, by means of high-speed photography. The information obtained from these three investig

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28

Kaduchak, Gregory, and Philip L. Marston. "E6 diffraction catastrophe in light scattered near the rainbow region of an acoustically levitated spheroidal water drop." Journal of the Acoustical Society of America 92, no. 4 (1992): 2474. http://dx.doi.org/10.1121/1.404436.

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29

AFKHAMI, S., A. J. TYLER, Y. RENARDY, et al. "Deformation of a hydrophobic ferrofluid droplet suspended in a viscous medium under uniform magnetic fields." Journal of Fluid Mechanics 663 (September 8, 2010): 358–84. http://dx.doi.org/10.1017/s0022112010003551.

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The effect of applied magnetic fields on the deformation of a biocompatible hydrophobic ferrofluid drop suspended in a viscous medium is investigated numerically and compared with experimental data. A numerical formulation for the time-dependent simulation of magnetohydrodynamics of two immiscible non-conducting fluids is used with a volume-of-fluid scheme for fully deformable interfaces. Analytical formulae for ellipsoidal drops and near-spheroidal drops are reviewed and developed for code validation. At low magnetic fields, both the experimental and numerical results follow the asymptotic sm

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30

Chashechkin, Yu D. "Acoustics and Hydrodynamics of the Drop Impact: Two Modes of Sound Packets Emission." Herald of the Bauman Moscow State Technical University. Series Natural Sciences, no. 1 (106) (February 2023): 23–44. http://dx.doi.org/10.18698/1812-3368-2023-1-23-44.

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The paper studies acoustic signals in two modes of merging with water in a freely falling water droplet by the matched optical and acoustic methods. Only the primary sound packet was observed in the intrusive mode at the low drop speed, when the cavity was formed with a delay in the colored wake of the inflowing liquid. Experiments demonstrated the drop speed influence on the primary signal parameters. At the high droplet speed, the cavity started to form from the moment of the initial contact. The flow pattern became more complicated, the droplet substance was distributed over the emerged cav

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31

Sanders, Jason L., and N. Wyn Evans. "Near-Gaussian distributions for modelling discrete stellar velocity data with heteroskedastic uncertainties." Monthly Notices of the Royal Astronomical Society 499, no. 4 (2020): 5806–25. http://dx.doi.org/10.1093/mnras/staa2860.

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ABSTRACT The velocity distributions of stellar tracers in general exhibit weak non-Gaussianity encoding information on the orbital composition of a galaxy and the underlying potential. The standard solution for measuring non-Gaussianity involves constructing a series expansion (e.g. the Gauss–Hermite series) that can produce regions of negative probability density. This is a significant issue for the modelling of discrete data with heteroskedastic uncertainties. Here, we introduce a method to construct positive-definite probability distributions by the convolution of a given kernel with a Gaus

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32

Erwin, Peter, Anil Seth, Victor P. Debattista, et al. "Composite bulges – II. Classical bulges and nuclear discs in barred galaxies: the contrasting cases of NGC 4608 and NGC 4643." Monthly Notices of the Royal Astronomical Society 502, no. 2 (2021): 2446–73. http://dx.doi.org/10.1093/mnras/stab126.

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ABSTRACT We present detailed morphological, photometric, and stellar-kinematic analyses of the central regions of two massive, early-type barred galaxies with nearly identical large-scale morphologies. Both have large, strong bars with prominent inner photometric excesses that we associate with boxy/peanut-shaped (B/P) bulges; the latter constitute ∼30 per cent of the galaxy light. Inside its B/P bulge, NGC 4608 has a compact, almost circular structure (half-light radius Re ≈ 310 pc, Sérsic n = 2.2) we identify as a classical bulge, amounting to 12.1 per cent of the total light, along with a n

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Roh, Hyewon, Hwisoo Kim, and Je-Kyun Park. "Construction of a Fibroblast-Associated Tumor Spheroid Model Based on a Collagen Drop Array Chip." Biosensors 11, no. 12 (2021): 506. http://dx.doi.org/10.3390/bios11120506.

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Spheroid, a 3D aggregate of tumor cells in a spherical shape, has overcome the limitations of conventional 3D cell models to accurately mimic the in-vivo environment of a human body. The spheroids are cultured with other primary cells and embedded in collagen drops using hang drop plates and low-attachment well plates to construct a spheroid–hydrogel model that better mimics the cell–cell and cell–extracellular matrix (ECM) interactions. However, the conventional methods of culturing and embedding spheroids into ECM have several shortcomings. The procedure of transferring a single spheroid at

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Akiya, Shinobu, Hiroshi Takahashi, Hiroshi Furukawa, et al. "A Case of One Eye with Gelatinous Drop-Like Corneal Dystrophy and the Other Eye with Band-Shaped Spheroidal Corneal Degeneration." Ophthalmologica 209, no. 2 (1995): 96–100. http://dx.doi.org/10.1159/000310589.

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35

Zieger, Viktoria, Ellen Woehr, Stefan Zimmermann, et al. "Automated Nanodroplet Dispensing for Large-Scale Spheroid Generation via Hanging Drop and Parallelized Lossless Spheroid Harvesting." Micromachines 15, no. 2 (2024): 231. http://dx.doi.org/10.3390/mi15020231.

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Creating model systems that replicate in vivo tissues is crucial for understanding complex biological pathways like drug response and disease progression. Three-dimensional (3D) in vitro models, especially multicellular spheroids (MCSs), offer valuable insights into physiological processes. However, generating MCSs at scale with consistent properties and efficiently recovering them pose challenges. We introduce a workflow that automates large-scale spheroid production and enables parallel harvesting into individual wells of a microtiter plate. Our method, based on the hanging-drop technique, u

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36

Lewis, Natasha S., Emily EL Lewis, Margaret Mullin, Helen Wheadon, Matthew J. Dalby, and Catherine C. Berry. "Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence." Journal of Tissue Engineering 8 (January 1, 2017): 204173141770442. http://dx.doi.org/10.1177/2041731417704428.

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Multicellular spheroids are an established system for three-dimensional cell culture. Spheroids are typically generated using hanging drop or non-adherent culture; however, an emerging technique is to use magnetic levitation. Herein, mesenchymal stem cell spheroids were generated using magnetic nanoparticles and subsequently cultured within a type I collagen gel, with a view towards developing a bone marrow niche environment. Cells were loaded with magnetic nanoparticles, and suspended beneath an external magnet, inducing self-assembly of multicellular spheroids. Cells in spheroids were viable

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37

Grigor’ev, A. I., A. R. Paranin, and S. O. Shiryaeva. "On the structure of the velocity field under the free spheroidal surface of a viscous liquid drop oscillating in an electrostatic field." Technical Physics 56, no. 9 (2011): 1250–58. http://dx.doi.org/10.1134/s106378421109009x.

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38

Butelmann, Tobias, Yawei Gu, Aijun Li, et al. "3D Printed Solutions for Spheroid Engineering and Cancer Research." International Journal of Molecular Sciences 23, no. 15 (2022): 8188. http://dx.doi.org/10.3390/ijms23158188.

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In multicellular organisms, cells are organized in a 3-dimensional framework and this is essential for organogenesis and tissue morphogenesis. Systems to recapitulate 3D cell growth are therefore vital for understanding development and cancer biology. Cells organized in 3D environments can evolve certain phenotypic traits valuable to physiologically relevant models that cannot be accessed in 2D culture. Cellular spheroids constitute an important aspect of in vitro tumor biology and they are usually prepared using the hanging drop method. Here a 3D printed approach is demonstrated to fabricate

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Su, Chengxun, Yon Jin Chuah, Hong Boon Ong, Hui Min Tay, Rinkoo Dalan, and Han Wei Hou. "A Facile and Scalable Hydrogel Patterning Method for Microfluidic 3D Cell Culture and Spheroid-in-Gel Culture Array." Biosensors 11, no. 12 (2021): 509. http://dx.doi.org/10.3390/bios11120509.

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Incorporation of extracellular matrix (ECM) and hydrogel in microfluidic 3D cell culture platforms is important to create a physiological microenvironment for cell morphogenesis and to establish 3D co-culture models by hydrogel compartmentalization. Here, we describe a simple and scalable ECM patterning method for microfluidic cell cultures by achieving hydrogel confinement due to the geometrical expansion of channel heights (stepped height features) and capillary burst valve (CBV) effects. We first demonstrate a sequential “pillar-free” hydrogel patterning to form adjacent hydrogel lanes in e

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40

Adekola, Aderemi Sikiru. "Computation of the Scattering Parameters Using Indian Lognormal Drop Size Distribution at 16, 19.3 and 34.8 GHz for Spherical and Oblate Spheroidal Rain Models." Asian Journal of Scientific Research 1, no. 3 (2008): 213–21. http://dx.doi.org/10.3923/ajsr.2008.213.221.

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Prabhakaran, Vinothini, Anya Sobrattee, Ferry P. W. Melchels, and Jennifer Z. Paxton. "ADVANCING THE FABRICATION OF 3D MINI-TISSUE ENTHESIS CONSTRUCTS: CHARACTERIZATION OF BONE, TENDON, AND BMSC SPHEROIDS." Orthopaedic Proceedings 105-B, SUPP_16 (2023): 42. http://dx.doi.org/10.1302/1358-992x.2023.16.042.

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AbstractObjectivesThe enthesis is a specialised structure at the interface between bone and tendon with gradual integration to maintain functionality and integrity. In the process of fabricating an in-vitro model of this complex structure, this study aims to investigate growth and maturation of bone, tendon and BMSC spheroids followed by 3D mini-tissue production.MethodsCell spheroids Spheroids of differentiated rat osteoblasts (dRObs), rat tendon fibroblasts (RTFs) and bone marrow stem cells (BMSC) were generated by culturing in 96 well U bottom cell repellent plates. With dROb spheroids prev

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42

Zahn, Ingrid, Tobias Braun, Clemens Gögele, and Gundula Schulze-Tanzil. "Minispheroids as a Tool for Ligament Tissue Engineering: Do the Self-Assembly Techniques and Spheroid Dimensions Influence the Cruciate Ligamentocyte Phenotype?" International Journal of Molecular Sciences 22, no. 20 (2021): 11011. http://dx.doi.org/10.3390/ijms222011011.

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Spheroid culture might stabilize the ligamentocyte phenotype. Therefore, the phenotype of lapine cruciate ligamentocyte (L-CLs) minispheroids prepared either by hanging drop (HD) method or by using a novel spheroid plate (SP) and the option of methyl cellulose (MC) for tuning spheroid formation was tested. A total of 250 and 1000 L-CLs per spheroid were seeded as HDs or on an SP before performing cell viability assay, morphometry, gene expression (qRT-PCR) and protein immunolocalization after 7 (HD/SP) and 14 (SP) days. Stable and viable spheroids of both sizes could be produced with both meth

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43

Pengsart, Worakamol, and Kasem Kulkeaw. "An Optical and Chemiluminescence Assay for Assessing the Cytotoxicity of Balamuthia mandrillaris against Human Neurospheroids." Bioengineering 9, no. 7 (2022): 330. http://dx.doi.org/10.3390/bioengineering9070330.

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A spheroid is a cell aggregate in a three-dimensional context; thereby, it recapitulates the cellular architecture in human tissue. However, the utility of spheroids as an assay for host–parasite interactions remains unexplored. This study demonstrates the potential use of neurospheroids for assessing the cytotoxicity of the life-threatening pathogenic amoeba Balamuthia mandrillaris. The neuroblastoma SH-SY5Y cells formed a spheroid in a hanging drop of culture medium. Cellular damage caused by B. mandrillaris trophozoites on human neuronal spheroids was observed using microscopic imaging and

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44

Schmal, Olga, Jan Seifert, Tilman E. Schäffer, Christina B. Walter, Wilhelm K. Aicher, and Gerd Klein. "Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture." Stem Cells International 2016 (2016): 1–13. http://dx.doi.org/10.1155/2016/4148093.

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Efficientex vivoexpansion of hematopoietic stem cells with a concomitant preservation of stemness and self-renewal potential is still an unresolved ambition. Increased numbers of methods approaching this issue using three-dimensional (3D) cultures were reported. Here, we describe a simplified 3D hanging drop model for the coculture of cord blood-derived CD34+hematopoietic stem and progenitor cells (HSPCs) with bone marrow-derived mesenchymal stromal cells (MSCs). When seeded as a mixed cell suspension, MSCs segregated into tight spheroids. Despite the high expression of niche-specific extracel

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Wassmer, Charles-Henri, Kevin Bellofatto, Lisa Perez, et al. "Engineering of Primary Pancreatic Islet Cell Spheroids for Three-dimensional Culture or Transplantation: A Methodological Comparative Study." Cell Transplantation 29 (January 1, 2020): 096368972093729. http://dx.doi.org/10.1177/0963689720937292.

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Three-dimensional (3D) cell culture by engineering spheroids has gained increasing attention in recent years because of the potential advantages of such systems over conventional two-dimensional (2D) tissue culture. Benefits include the ability of 3D to provide a more physiologically relevant environment, for the generation of uniform, size-controlled spheroids with organ-like microarchitecture and morphology. In recent years, different techniques have been described for the generation of cellular spheroids. Here, we have compared the efficiency of four different methods of islet cell aggregat

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Shahi Thakuri, Pradip, and Hossein Tavana. "Single and Combination Drug Screening with Aqueous Biphasic Tumor Spheroids." SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, no. 5 (2017): 507–15. http://dx.doi.org/10.1177/2472555217698817.

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Spheroids of cancer cells represent a physiologic model of solid tumors for cancer drug screening. Despite this known benefit, difficulties with generating large quantities of uniformly sized spheroids in standard plates, individually addressing spheroids with drug compounds, and quantitatively analyzing responses of cancer cells have hindered the use of spheroids in high-throughput screening applications. Recently, we addressed this challenge by using an aqueous two-phase system technology to generate a spheroid within an aqueous drop immersed in a second, immiscible aqueous phase. Integratin

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Eroğlu, Erdal. "In vitro 3D Spheroid Culture Developed on the Parafilm Surface Using HEK-293 Cells." Academic Perspective Procedia 3, no. 1 (2020): 220–27. http://dx.doi.org/10.33793/acperpro.03.01.48.

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Preclinical research to predict the effects of drugs and chemicals on humans is commonly carried out either by cell culture studies in vitro condition or on animals in vivo condition. While drug studies tested on cells cultured as a monolayer in plastic flasks are incompatible with realistic results, falsifying findings can also be achieved from in vivo studies performed on different species. In recent years, research on drug tests using spheroid cultures formed by growing cells in three-dimensional (3D) in vitro has attracted great interest. 3D spheroid structures are formed by growing the ce

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Walenta, Stefan, Joerg Doetsch, Wolfgang Mueller-Klieser, and Leoni A. Kunz-Schughart. "Metabolic Imaging in Multicellular Spheroids of Oncogene-transfected Fibroblasts." Journal of Histochemistry & Cytochemistry 48, no. 4 (2000): 509–22. http://dx.doi.org/10.1177/002215540004800409.

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Four rat embryo fibroblast (REF) cell lines with defined oncogenic transformation were used to study the relationship between tumorigenic conversion, metabolism, and development of cell death in a 3D spheroid system. Rat1 (spontaneously immortalized) and M1 ( myc-transfected) fibroblasts represent early nontumorigenic transformation stages, whereas Rat1-T1 (T24Ha- ras-transfected Rat1) and MR1 ( myc/T24Ha- ras-co-transfected REF) cells express a highly tumorigenic phenotype. Localized ATP, glucose, and lactate concentrations in spheroid median sections were determined by imaging bioluminescenc

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Zadorozhnaya, Ludmila A., Andrey P. Tarasov, and Vladimir M. Kanevsky. "The Growth Mechanism, Luminescence, and Lasing of Polyhedral ZnO Microcrystals with Whispering-Gallery Modes." Photonics 10, no. 12 (2023): 1328. http://dx.doi.org/10.3390/photonics10121328.

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This work studies the features of the formation of isometric polyhedral ZnO microcrystals that provide stimulated emission and whispering-gallery-mode (WGM) lasing in the near-UV range. For this purpose, the growth stages of such crystals in the process of gas-transport synthesis and the luminescent properties of the structures obtained at each stage were investigated. It was shown that the growth of laser microcrystals begins with the formation of microspheroids with thin ZnO shells. Such spheroids exhibit mainly white luminescence with a small contribution of near-UV emission. Increasing the

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Robinson, Stephen, Eric Parigoris, Jonathan Chang, Louise Hecker, and Shuichi Takayama. "Contracting scars from fibrin drops." Integrative Biology 14, no. 1 (2022): 1–12. http://dx.doi.org/10.1093/intbio/zyac001.

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Abstract This paper describes a microscale fibroplasia and contraction model that is based on fibrin-embedded lung fibroblasts and provides a convenient visual readout of fibrosis. Cell-laden fibrin microgel drops are formed by aqueous two-phase microprinting. The cells deposit extracellular matrix (ECM) molecules such as collagen while fibrin is gradually degraded. Ultimately, the cells contract the collagen-rich matrix to form a compact cell-ECM spheroid. The size of the spheroid provides the visual readout of the extent of fibroplasia. Stimulation of this wound-healing model with the profib

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