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Relevant bibliographies by topics / Spheronization

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Academic literature on the topic 'Spheronization'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 June 2025

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Journal articles on the topic "Spheronization"

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Zhang, Rui Shi, J. Z. Pan, and L. W. Wang. "Manufacture of Fine AL₂O₃Granules as Catalyst Carrier by an Extrusion/Spheronization Method." Advanced Materials Research 44-46 (June 2008): 361–66. http://dx.doi.org/10.4028/www.scientific.net/amr.44-46.361.

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The effect of formulation (filler’s kind and amount, liquid’s kind and concentration required for granulation) and spheronization time on characterization of alumina based pellets parameters (pellets size distribution, roundness and aspect ratio) were investigated. Two schemes were successfully proofed by extrusion/spheronization. The mean volume particle diameter was found to have a profound effect on the formulation and processing parameters. Alumina powder with large mean volume particle diameter showed different mechanism of action with coupling agent. With the surface modification, the water required for granulation had decreased. The existing formal and kinematic velocity of the water had a direct effect on the processing parameter of the extrusion and spheronization. Spheronization time from 2 to 10 min had a pronounced effect on roundness and aspect ratio. No changes in roundness and aspect ratio were observed from 10 to 20 min of spheronization time.

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Rojas, John, and David Correa. "ASSESSMENT OF THE PRODUCTION VARIABLES ON THE PELLETIZATION PROPERTIES OF MICROCRYSTALLINE CELLULOSE II (MCCII)." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (2017): 73. http://dx.doi.org/10.22159/ijpps.2017v9i10.20580.

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Objective: To study microcrystalline cellulose II (MCCII) as new pelletization aid using the extrusion/spheronization technology.Methods: The effect of the spheronization rate and spheronization time was assessed by a response surface design. The shape descriptors and physical properties of pellets were taken as response variables. Approximately, 30 g of MCCII were hydrated, passed through a # 20 mesh sieve and spheronizated at frequencies of 6, 9 and 12 Hz and residence times of 15, 240 and 480 s in 9 experimental runs. In a separate experimental set, moisture levels of 25, 50, 75, 100 and 125% were employed at the optimal operating conditions of 6 Hz and 480 s. A microscopy analysis was used to evaluate the shape descriptors. Pellets properties such as compressibility, friability, porosity, strength, flow rate and mass were also evaluated.Results: Pellets having a small size and a high value of shape descriptors related to morphology were obtained employing a spheronization rate and spheronization time of 6Hz and 480s and 100% wetting level. The spheronization time increased pellet densification but decreased the total porosity. Pellet mass was also favoured by using high spheronization rates. A high moisture level (>100%) rendered pellets having a large size, mass, low porosity and good yield. Conversely, pellet size decreased as sample load increased, whereas porosity and compressibility increased as sample load augmented.Conclusion: MCCII offers the potential for use as an alternative pelletization agent rendering pellets having a good flowability, high mechanical strength and low friability at the optimal operational conditions.

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Jain, Satishkumar P., Pirthi Pal Singh, and Purnima D. Amin. "Alternative extrusion–spheronization aids." Drug Development and Industrial Pharmacy 36, no. 11 (2010): 1364–76. http://dx.doi.org/10.3109/03639045.2010.482590.

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Iyer, R. M., L. L. Augsburger, D. G. Pope, and R. D. Shah. "Extrusion/Spheronization—Effect of Moisture Content and Spheronization Time on Pellet Characteristics." Pharmaceutical Development and Technology 1, no. 4 (1996): 325–31. http://dx.doi.org/10.3109/10837459609031427.

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Santoso, Rahmat, and Fiqi Aliudin. "KAJIAN PUSTAKA FORMULASI DAN EVALUASI MIKROKAPSUL SALUT ENTERIK MENGGUNAKAN ACRYL-EZE® & SURETERIC DENGAN METODE PENGGABUNGAN MIKROENKAPSULASI DENGAN EKSTRUSI-SFERONISASI." Jurnal Riset Kefarmasian Indonesia 2, no. 3 (2020): 122–36. http://dx.doi.org/10.33759/jrki.v2i3.89.

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Microcapsules were prepared by means of microencapsulation modified by the extrusion-spheronization method. The extrusion-spheronization method is used to cover the shortcomings of the microencapsulation method. The results showed that Acryl-eze and Sureterik can be used in coatings in producing microcapsules. The results of research evaluating the formulation of enteric acetosal coated microcapsules have not resulted in delayed release system that is in accordance with monographic requirements and dissolution profile testing has not shown the elimination stage. The results of the evaluation of the delayed release release system enteric coated microcapsule formulation met the requirements of monograph and dissolution profile test results, except for F3 in buffering conditions. The purpose of this literature review is to examine the enteric-coated microcapsule formulation using Acryl-eze® & Sureteric by combining microencapsulation and spheronization extrusion methods.

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Bueva, Viktorija Vladimirovna, Evgenija Viktorovna Blynskaja, Sergej Valer’evich Tishkov, Viktor Konstantinovich Alekseev, and Konstantin Viktorovich Alekseev. "General aspects of extrusion-spheronisation as a pellet production technique." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 3 (June 15, 2022): 8–21. http://dx.doi.org/10.33920/med-13-2206-01.

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Various aspects of the extrusion-spheronisation technique as one of the most popular pellets production methods was considered in this review. The advantages of extrusion-spheronization in comparison with other methods are the ability to include high-dose pharmaceutical substances, combine two or more substances, as well as change the physical characteristics of initial material. In addition, the method allows to obtain particles with excellent flowability, low hygroscopicity, high sphericity, narrow particle size distribution and smooth surface The main advantages and disadvantages of the equipment used are shown, and the process initial parameters influence on the obtained material final properties is noted. Particular attention is paid to such stages of extrusion-spheronization as obtaining a wet mass and it’s following extrusion-spheronization, varying parameters of which is possible to change the pellets morphological and technological properties.

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Uličná, Miriam, Roman Fekete, Martin Juriga, Juraj Kabát, Peter Peciar, and Marian Peciar. "Influence of Die Length on Extrusion Pressure and Extrudate Surface Quality." Strojnícky časopis - Journal of Mechanical Engineering 73, no. 1 (2023): 187–96. http://dx.doi.org/10.2478/scjme-2023-0015.

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Abstract The extrusion process is very popular in industry. Nowadays, extrusion is also closely associated with the 3D printing process, but this article is focused on extrusion, as a process that is mainly associated with spheronization. The extrusion product is shaped in such a way that it is suitable for the ongoing spheronization process. With this two-step extrusion-spheronization (E–S) process, it is possible to create pellets with controlled high sphericity, which are desired in tablet and capsule production due to their easily characterized (and controlled) dosage profile and good flow properties. During extrusion, it is important to monitor several parameters. This post is dedicated to one of them and that is the length of the die and its effect on the extrusion pressure as well as the effect on the extrudate surface quality.

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Reitz, Claudia, and Peter Kleinebudde. "Spheronization of solid lipid extrudates." Powder Technology 189, no. 2 (2009): 238–44. http://dx.doi.org/10.1016/j.powtec.2008.04.009.

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Kuvshynov, Oleksii, and Nataliia Kuvshynova. "SPHERONIZER WITH THE STUDY OF DYNAMIC CHARACTERISTICS OF GRANULES." Scientific Journal of Polonia University 54, no. 5 (2022): 159–69. http://dx.doi.org/10.23856/5421.

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The article contains a description of the technological process in which the spheronizer is located on the basis of the extruder-spheronizer, its purpose and place in the technological scheme are considered. The study presents technical characteristics, considered the design and principle of action of the unit for spheronization, performed certain calculations that confirm the efficiency and reliability of the machine. The purpose of this article is to consider the spheronizer with the study of the dynamic characteristics of the granules. The spheronizer extruder, or spheronizer, is widely used in the granulation of spherical parts and granules. The working material for the spheronizer is non-spheroidal solid particles that turn into spheroids during the spheronization process. To optimize the production of spherical particles in a spheronizer, it is necessary to know all the intricacies of this process, therefore, in this work, the stress-strained state of extrudates, which undergo certain changes during the spheronization process, is investigated using the "finite element" method. The research is based on actual data obtained by different scientists, and on the results of the authors' own observations.

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M. P., Gowrav, Umme Hani, Hosakote G. Shivakumar, Riyaz Ali M. Osmani, and Atul Srivastava. "Polyacrylamide grafted guar gum based glimepiride loaded pH sensitive pellets for colon specific drug delivery: fabrication and characterization." RSC Advances 5, no. 97 (2015): 80005–13. http://dx.doi.org/10.1039/c5ra17257h.

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Dissertations / Theses on the topic "Spheronization"

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Fielden, Krystyna Elzbieta. "Extrusion and spheronization of microcrystalline cellulose and lactose mixtures." Thesis, University College London (University of London), 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445344.

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CESPI, MARCO. "MECHANICAL AND COMPRESSION CHARACTERIZATION OF PELLETES PREPARED BY EXTRUSION-SPHERONIZATION." Doctoral thesis, Università degli Studi di Camerino, 2008. http://hdl.handle.net/11581/401889.

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Part 1 The first part concern the characterization of mechanical and compression properties of pellets prepared by extrusion-spheronization. Thirteen batches of pellets were prepared all in the same condition, using five materials (corn starch, Î±-lactose monohydrate, anhydrous dicalcium phosphate, peg 6000 and amidated pectin) plus microcrystalline cellulose as main binder, in fixed ratio, 75, 50 and 25% respect the cellulose amount. A further batch was prepared using only microcrystalline cellulose. A characterization program were carried out on the compression and mechanical properties of the starting materials, powder mixtures and pellets, the latter analysed either as single unit that during compression. Results showed as pellets compaction behaviour is strongly related to the properties of powder mixtures used for their preparation and it could be also derived from single components characteristics according with the ratio used. Diametrical compression tests and pellets images before and after such test enabled to link mixtures and pellets compaction behaviour, moreover these tests allowed to classify pellets as fragmenting and deforming. Despite the similar compaction mechanism mixtures and pellets behaved completely different in term of tablettability. A marked increase on surface area resulted crucial in order to obtain pellets tablets, as confirmed by the fragmenting batches results. All pellets classified as deforming seem suitable as core materials for the film coating application,in the preparation of multiparticulate controlled release tablets. They resist to the compaction process retaining their shape, so they represent good system in order the maintain the film integrity. All pellets classified as fragmenting pellets do not result useful as ''cushioning agents'' in multiparticulate controlled release tablets. Moreover the spheronization carried out on dense extrudate (as in this case) do not represent the best methodology for this purpose. Part 2 The second part, carried out at the school of pharmacy and chemistry, John Moore University (UK) under the supervision of Dr. M. Roberts, concerning the influence of hydro-ethanolic media on the aspirin release profiles from hypromellose matrices. Percent aspirin released increased with increasing levels of ethanol in the dissolution media, correlating with the drug's solubility, however,dose dumping of aspirin did not occur. An initial rapid release was observed in media comprising 40% ethanol. Release in these conditions was considered to be both erosion and diffusion-mediated, in contrast to the release in 0, 10, 20 and 30% ethanol media, where erosion-controlled release dominated. Image analysis of matrix swelling indicated a slower initial interaction between ethanol and hypromellose accounting for the initial rapid release. Cloud point studies suggested that ethanol retarded hydration of the polymer.

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Zhang, Jinzhou. "Preparation and characterization of oxidized cellulose beads by extrusion/spheronization for chemoembolization." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/2028.

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Transarterial chemoembolization (TACE) has been practiced in patients for over 30 years and describes the infusion of chemotherapeutic agents followed by embolic particles. This infusion is normally performed by selecting tumor feeding arteries with a catheter under image guidance. The overall goal of TACE is to deliver a high dose of drug directly to a tumor, prevent drug clearance, and induce ischemic necrosis of the tumor. The limitations for current beads system including non-biodegradable and biodegradable beads used for TACE are low drug loading and only water soluble drug can be loaded in beads. The drug loading methods used in current beads system were ion-exchange method and expanding-loading-shrinking method, but these methods didn't allow loading high drug content (up to 10% drug loading) and water insoluble drug. The other limitation for current biodegradable beads used for TACE only had narrow size range beads. In those instances where treatment is not complete or the tumor recurs, physicians would like to be able to access a tumor on multiple occasions in order to administer additional TACE treatments as needed. It may not be possible to re-enter the feeding artery once this artery had been occluded by non-biodegradable beads. For overcoming above limitations, the goal in this study is developing a new biodegradable bead which should have wide size range, achieve high drug loading and high drug loading efficiency, and load water soluble and water insoluble drug. Extrusion/spheronization technology was chosen for drug loading method. It must be noted that not every polymer can be successfully extruded and spheronized. Oxidized cellulose (OC) was chosen in this study, which is biodegradable polymer. OC was evaluated as new excipient for extrusion/spheronization in this study. Differential scanning calorimetry (DSC) and dynamic vapor sorption analysis were used to compare the interaction and distribution of water within MCC and OC. The amounts of nonfreezing and freezing water in hydrated samples were determined from melting endotherms obtained by DSC. The moisture sorption profiles were analyzed according to the GAB equations. The adsorbed monolayer was not statistically different for MCC and OC after accounting for the amorphous content of the polymers. These results suggest that OC can act as a “molecular sponge,'' and thus aid in the production of beads by extrusion and spheronization. A composite central design was used to evaluate the influence of spheronizer speed, spheronizer time and water level (granulation liquid,) on pellet yield and sphericity. All factors as well as the interactions between water level and spheronizer speed were significant (P<0.05) for sphericity. And water level was significant (P<0.05) for pellet yield. The water insoluble drug, methotrexate (MTX), was used in this study. The drug content of OC and OC/carbopol beads was up to 40% and drug loading efficiency was 100%. The swelling ratio of the MTX loaded OC/carbopol beads were up to 200%, and the swelling ratio was decreased when drug content was increased. Comparing to commercial embolization produce Contour SE, OC and OC/carbopol beads were significantly more compressible. Recoverability of OC/carbopol beads is close to Contour SE. The beads stability increased with an increase in the MTX content. 100-900 μm beads could be delivered through from 18G to 23G needles. The release method involved the use of a T-Apparatus where the drug experiences an element of diffusion through a static environment. This method was developed to resemble the in -vivo situation in embolization procedures more closely. Release results showed from 57% to 78% MTX was released from OC/carbopol beads in 6 days depending on the drug content. OC as new pelletization aid can be used to produce beads by using extrusion/spheronization. The new biodegradable OC base beads have wide size range, achieve high drug loading (up to 40%) and high drug loading efficiency, and are able to load water soluble and water insoluble drug. Physical and mechanical properties of MTX loaded OC base beads match the requirement for catheter deliverability. The result of release study showed slow release. The biodegradable OC base beads are suitable for TACE.

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Köster, Martin [Verfasser], Peter [Akademischer Betreuer] Kleinebudde, and Jörg [Akademischer Betreuer] Breitkreutz. "Spheronization Process - Particle Kinematics and Pellet Formation Mechanism / Martin Köster. Gutachter: Peter Kleinebudde ; Jörg Breitkreutz." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2013. http://d-nb.info/1036727556/34.

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Pather, Sathasivan Indiran. "An investigation of the production of non-coated sustained release beads by extrusion and Spheronization." University of the Western Cape, 1995. http://hdl.handle.net/11394/8457.

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Doctor Pharmaceuticae - DPharm<br>The popularity and increasing complexity of sustained release dosage forms has resulted in increased costs to the patient. One approach to achieve cheaper, yet effective, sustained release medication is through the simplification of production processes. Matrix tablets have been used to sustain the release of numerous drugs and are cheap to prepare. Since they are single-unit dosage forms, however, they display less predictable transit through the gastrointestinal tract. Hence, they provide less reliable blood levels of the drug in comparison with multi particulate dosage forms. Of the various types of multiparticulates available, pellets are popular for oral administration. A fairly recent innovation, in pelletization technology, is extrusion and spheronization. With this technique it is possible to produce pellets with a high degree of drug loading directly and rapidly. The drug loaded beads are usually coated for a sustained release effect. If one could omit the coating step, it would avoid many problems (thus reducing the number of quality control procedures required) and save chemicals, labour and capital for the purchase of additional equipment. The primary aim of this project was to investigate the preparation of non-coated, spheronized sustained release pellets, while a secondary aim was to prepare beads that can be compressed into sustained release tablets. A tablet can accommodate a larger mass and the compaction forces involved may enhance the sustained release effect. Several techniques were used in an attempt to sustain the release of drugs of different solubilities. In one series of formulations, a novel method was used to incorporate a binder consisting of ethylcellulose in ethanol. Using this technique, the release of Theophylline was sustained for approximately 8 hours. In other formulations, several materials were added to beads with the aim of forming sustained release matrixes. Only magnesium stearate was able to prolong the release of Acetaminophen and Theophylline for a reasonable time. In an attempt to explain why materials that were successfully used in sustained release matrix tablets were of very limited value in beads, an equation was developed to calculate the approximate distance between the retardant particles. Calculations using this equation revealed that the retardant particles were too far apart, within each bead, to expect consolidation to occur. The discrete retardant particles do not retard drug release effectively. Eudragit?-containing beads, which sustained the release of the drug to a small extent, were successfully compressed into tablets, both on their own and in combination with non pareil seeds. In each case, the sustained release effect was improved by compaction. In the case of the products manufactured with non pareil seeds, the tablets disintegrated rapidly to release the beads, thus ensuring that the advantages of multiparticulates were maintained. Because it was realised that a large amount of the matrix material could not be incorporated within the beads if a high dose drug was formulated with Avicel? PH 101, the idea of forming the matrix outside the beads was developed. Several materials were tried in an attempt to form a sustained release external matrix. Eudragit? RSPO prolonged the dissolution of Theophylline for more than four hours. Magnesium stearate was able to sustain the release of Acetaminophen and Theophylline appreciably. In the latter case, the dissolution, in water, of a standard adult dose of the drug was prolonged for more than 12 hours. However, the dissolution in an acidic medium was much faster. The described technique represents an advance in extrusion and spheronization technology. While beads containing Cutina? HR did not show promise as sustained release units, they compacted to form sustained release tablets of good appearance and acceptable strength. These tablets were considered to have been efficiently prepared because the constituent beads were easily manufactured and showed good flowability, and because a glidant and a lubricant were not required. The production of sustained release Indomethacin beads with a more steady release profile than the innovator's product has also been described in other experiments. The research described in this thesis represents progress towards the widespread commercial production of effective non-coated sustained release beads and may encourage further work towards this goal.

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Tomer, Gil. "An investigation of the role of water in the process of extrusion/spheronization of model formulations." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391823.

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Chatchawalsaisin, Jittima. "The influence of hydrophobic additives on the formation and drug release from pellets prepared by extrusion/spheronization." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299281.

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Chinyemba, Patience. "Use of Aloe vera and Aloe marlothii materials as excipients in beads produced by extrusion-spheronization / Patience Chinyemba." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9641.

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Microcrystalline cellulose (MCC) is the most commonly used excipient in the manufacture of spherical particles or beads by extrusion spheronisation. However, the use of MCC in beads has its limitations such as prolonged release of drugs due to lack of disintegration. The aim of this study was to determine if Aloe vera and Aloe marlothii leaf materials can be used as excipients in the production of beads prepared by extrusion spheronisation. A 23 full factorial design was employed for optimisation and to explore the effects of the concentration of MCC, polyvinylpyrrolidone and aloe materials on the sphericity and release rate of ketoprofen. Scanning electron microscopy revealed more porous beads when aloe materials were included in the bead formulations compared to the formulation with MMC alone. The bead formulations containing aloe materials exhibited faster drug release compared to that of the formulation containing MCC alone. Dissolution data of the optimised formulations were analysed in terms of mean dissolution time (MDT) as well as fit factors (f1 and f2). The optimised bead formulations had dissolution profiles comparable to that of the formulation containing MCC alone at pH 1.2 and 4.5 (f2 values > 70), but less comparable to the reference at pH 6.8 (50 < f2< 65) due to faster drug release. Aloe vera and Aloe marlothii leaf materials can be used successfully together with MCC in the production of beads by extrusion spheronisation.<br>Thesis (MSc (Pharmaceutics))--North-West University, Potchefstroom Campus, 2013.

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Nguyen, Thi Trinh Lan. "Extrusion- spheronization of pharmaceutical products : system for the delivery of active ingredients which are poorly soluble by oral route." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF047/document.

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L'amélioration de la dissolution des médicaments peu solubles présente de nombreux défis.Dans cette thèse, un procédé d'extrusion-sphéronisation a été étudié en profondeur pour améliorer la dissolubilité du médicament avec une formulation de nano-émulsion. Le but du travail de thèse est de décrire les propriétés et les procédés de fabrication de minigranules permettant d'augmenter la solubilité des principes actifs peu solubles dans l'eau et donc d‘améliorer leur biodisponibilité lors de l'administration par voie orale, pour deux modèles de molécules différentes qui sont l‘acide folique (vitamine peu soluble dans l'eau) et le kétoprofène (anti-inflammatoire non stéroïdien qui présente une solubilité limitée dans les fluides gastriques à cause de son pKa (classe II dans le système de classification biopharmaceutique – BCS, ayant une action anti-inflammatoire, antalgique et antipyrétique). Cette étude décrit la préparation par extrusion-sphéronisation, caractérisation et étude de dissolution in vitro d'acide folique et de pastilles de kétoprofène revêtues de Acryl-EZE®, Advantia® Performance dans un minicoatère à lit fluidisé. Les résultats des essais ont montré la faisabilité de la préparation de pastilles enrobées entériques contenant un AINS et que, en revêtant le système multiparticulaire avec Acryl-EZE® 93A92545 et Advantia® Performance190024HA49 à un gain pondéral de 17,5%, 12,0%, respectivement, du médicament à partir des pastilles peuvent être obtenus. Les résultats des essais de dissolution ont indiqué que dans un milieu acide, le revêtement de film a entraîné un retard dans la libération du médicament, alors qu'aucun retard n'a été observé dans un milieu tampon à pH 6,8<br>Improvement in dissolution of poorly soluble drugs has many challenges.In this thesis, an extrusion-spheronization process was thoroughly studied forimproving dissolubility of drug with nano-emulsion formulation.The aim of the thesis work is to describe the properties and manufacturing processes ofpellets to increase the solubility of poorly soluble active ingredients in water and thus improvetheir bioavailability when administered orally: folic acid (water-insoluble vitamin) andketoprofen (Non-steroidal anti-inflammatory, having anti-inflammatory, analgesic andantipyretic action, class II in the Biopharmaceutical Classification System).This study describes the preparation by extrusion-spheronization, characterisation andin vitro dissolution study of folic acid and ketoprofen pellets. Ketoprofen pellets coated withAcryl-EZE®, Advantia® Performance in a fluid-bed minicoater. The results of the tests showedthe feasibility of the preparation of enteric-coated pellets containing a NSAID and that bycoating the multiparticulate system with either 17.5% Acryl-EZE® 93A92545 or with 12%Advantia® Performance 190024HA49 weight gain, an enteric release of the drug from thepellets can be obtained. The results of dissolution testing indicated that in acidic media, entericfilm coating resulted in a delay in the release of the drug, while no delay was observed in pH6.8 buffer media

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Abdalla, Ahmed Mohamed Effat M. [Verfasser], Karsten [Akademischer Betreuer] Mäder, Alfred [Akademischer Betreuer] Blume, and Michaela [Akademischer Betreuer] Schulz-Siegmund. "Development and characterization of self-emulsifying pellets by extrusion, spheronization / Ahmed Mohamed Effat Mohamed Abdalla. Betreuer: Karsten Mäder ; Alfred Blume ; Michaela Schulz-Siegmund." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2008. http://d-nb.info/1024859045/34.

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Book chapters on the topic "Spheronization"

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O’Connor, Robert E., and Joseph B. Schwartz. "Extrusion and Spheronization Technology." In Pharmaceutical Pelletization Technology. CRC Press, 2022. http://dx.doi.org/10.1201/9781003066231-9.

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Nguyen, Thi Trinh Lan, Nicolas Anton, and Thierry F. Vandamme. "Nutraceutical compounds encapsulated by extrusion-spheronization." In New Polymers for Encapsulation of Nutraceutical Compounds. John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119227625.ch9.

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Erkoboni, David F. "Extrusion/Spheronization as a Granulation Technique." In Handbook of Pharmaceutical Granulation Technology, 4th ed. CRC Press, 2021. http://dx.doi.org/10.1201/9780429320057-12-14.

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Thommes, Markus, and Peter Kleinebudde. "The Science and Practice of Extrusion-Spheronization." In Advances in Delivery Science and Technology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7012-4_3.

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Natarajan, Jawahar, and Veera Venkata Satyanarayana Reddy Karri. "Formulation and Comparison of Lipophilic Drugs Through Self-Emulsifying Pellets Using Extrusion–Spheronization Technique." In Nanoparticles in Polymer Systems for Biomedical Applications. Apple Academic Press, 2018. http://dx.doi.org/10.1201/9781351047883-7.

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Villar-López, M. E., F. Otero-Espinar, and J. Blanco-Méndez. "Preparation by Extrusion/Spheronization of Triamcinolone / ß-Cyclodextrin Pellets as a Fast Release Dosage Form." In Proceedings of the Ninth International Symposium on Cyclodextrins. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4681-4_115.

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"Extrusion/Spheronization." In Pharmaceutical Extrusion Technology. CRC Press, 2003. http://dx.doi.org/10.1201/9780203911532-18.

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Erkoboni, David. "Extrusion/Spheronization." In Drugs and the Pharmaceutical Sciences. Informa Healthcare, 2003. http://dx.doi.org/10.1201/9780203911532.ch15.

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Jacob, Michael. "Spheronization, Granulation, Pelletization, and Agglomeration Processes." In Microencapsulation in the Food Industry. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-404568-2.00009-1.

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"Extrusion-Spheronization as a Granulation Technique." In Handbook of Pharmaceutical Granulation Technology. CRC Press, 2016. http://dx.doi.org/10.3109/9781616310035-15.

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Conference papers on the topic "Spheronization"

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Ibrahim, Yousif, Katalin Kristó, Géza Regdon, and Tamás Sovány. "Effect of Processing Conditions and Material Attributes on the Design Space of Lysozyme Pellets Prepared by Extrusion/Spheronization." In II. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2020. http://dx.doi.org/10.14232/syrptbrs.2020.op34.

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Reports on the topic "Spheronization"

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Dimitrov, Milen, and Teodora Popova. Technological and Biopharmaceutical Characterization of Ethylcellulose-based Pellets with Montelukast Sodium Prepared via Wet Extrusion and Spheronization. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, 2018. http://dx.doi.org/10.7546/crabs.2018.05.06.

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