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Dissertations / Theses on the topic 'Spheronization'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 June 2025

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1

Fielden, Krystyna Elzbieta. "Extrusion and spheronization of microcrystalline cellulose and lactose mixtures." Thesis, University College London (University of London), 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445344.

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2

CESPI, MARCO. "MECHANICAL AND COMPRESSION CHARACTERIZATION OF PELLETES PREPARED BY EXTRUSION-SPHERONIZATION." Doctoral thesis, Università degli Studi di Camerino, 2008. http://hdl.handle.net/11581/401889.

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Part 1 The first part concern the characterization of mechanical and compression properties of pellets prepared by extrusion-spheronization. Thirteen batches of pellets were prepared all in the same condition, using five materials (corn starch, Î±-lactose monohydrate, anhydrous dicalcium phosphate, peg 6000 and amidated pectin) plus microcrystalline cellulose as main binder, in fixed ratio, 75, 50 and 25% respect the cellulose amount. A further batch was prepared using only microcrystalline cellulose. A characterization program were carried out on the compression and mechanical properties of t

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3

Zhang, Jinzhou. "Preparation and characterization of oxidized cellulose beads by extrusion/spheronization for chemoembolization." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/2028.

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Transarterial chemoembolization (TACE) has been practiced in patients for over 30 years and describes the infusion of chemotherapeutic agents followed by embolic particles. This infusion is normally performed by selecting tumor feeding arteries with a catheter under image guidance. The overall goal of TACE is to deliver a high dose of drug directly to a tumor, prevent drug clearance, and induce ischemic necrosis of the tumor. The limitations for current beads system including non-biodegradable and b

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4

Köster, Martin [Verfasser], Peter [Akademischer Betreuer] Kleinebudde, and Jörg [Akademischer Betreuer] Breitkreutz. "Spheronization Process - Particle Kinematics and Pellet Formation Mechanism / Martin Köster. Gutachter: Peter Kleinebudde ; Jörg Breitkreutz." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2013. http://d-nb.info/1036727556/34.

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5

Pather, Sathasivan Indiran. "An investigation of the production of non-coated sustained release beads by extrusion and Spheronization." University of the Western Cape, 1995. http://hdl.handle.net/11394/8457.

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Doctor Pharmaceuticae - DPharm<br>The popularity and increasing complexity of sustained release dosage forms has resulted in increased costs to the patient. One approach to achieve cheaper, yet effective, sustained release medication is through the simplification of production processes. Matrix tablets have been used to sustain the release of numerous drugs and are cheap to prepare. Since they are single-unit dosage forms, however, they display less predictable transit through the gastrointestinal tract. Hence, they provide less reliable blood levels of the drug in comparison with multi partic

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6

Tomer, Gil. "An investigation of the role of water in the process of extrusion/spheronization of model formulations." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391823.

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7

Chatchawalsaisin, Jittima. "The influence of hydrophobic additives on the formation and drug release from pellets prepared by extrusion/spheronization." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299281.

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8

Chinyemba, Patience. "Use of Aloe vera and Aloe marlothii materials as excipients in beads produced by extrusion-spheronization / Patience Chinyemba." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9641.

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Microcrystalline cellulose (MCC) is the most commonly used excipient in the manufacture of spherical particles or beads by extrusion spheronisation. However, the use of MCC in beads has its limitations such as prolonged release of drugs due to lack of disintegration. The aim of this study was to determine if Aloe vera and Aloe marlothii leaf materials can be used as excipients in the production of beads prepared by extrusion spheronisation. A 23 full factorial design was employed for optimisation and to explore the effects of the concentration of MCC, polyvinylpyrrolidone and aloe materials on

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9

Nguyen, Thi Trinh Lan. "Extrusion- spheronization of pharmaceutical products : system for the delivery of active ingredients which are poorly soluble by oral route." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF047/document.

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L'amélioration de la dissolution des médicaments peu solubles présente de nombreux défis.Dans cette thèse, un procédé d'extrusion-sphéronisation a été étudié en profondeur pour améliorer la dissolubilité du médicament avec une formulation de nano-émulsion. Le but du travail de thèse est de décrire les propriétés et les procédés de fabrication de minigranules permettant d'augmenter la solubilité des principes actifs peu solubles dans l'eau et donc d‘améliorer leur biodisponibilité lors de l'administration par voie orale, pour deux modèles de molécules différentes qui sont l‘acide folique (vitam

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10

Abdalla, Ahmed Mohamed Effat M. [Verfasser], Karsten [Akademischer Betreuer] Mäder, Alfred [Akademischer Betreuer] Blume, and Michaela [Akademischer Betreuer] Schulz-Siegmund. "Development and characterization of self-emulsifying pellets by extrusion, spheronization / Ahmed Mohamed Effat Mohamed Abdalla. Betreuer: Karsten Mäder ; Alfred Blume ; Michaela Schulz-Siegmund." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2008. http://d-nb.info/1024859045/34.

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11

Silva, Filho Omar Paulino. "Obtenção de pellets a partir dos extratos líquidos padronizados de Brosimum gaudichaudii Trécul (Moraceae) ou Lafoensia pacari A. St.-Hil. (Lythraceae)." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/7463.

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Submitted by JÚLIO HEBER SILVA (julioheber@yahoo.com.br) on 2017-06-13T20:14:26Z No. of bitstreams: 2 Dissertação - Omar Paulino da Silva Filho - 2014.pdf: 773195 bytes, checksum: 68a3f309ec2cd70a400359919399ad6b (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-06-14T15:25:01Z (GMT) No. of bitstreams: 2 Dissertação - Omar Paulino da Silva Filho - 2014.pdf: 773195 bytes, checksum: 68a3f309ec2cd70a400359919399ad6b (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (

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12

Kratz, Cristiane de Pellegrini. "Obtenção de comprimidos contendo grânulos deformantes e grânulos revestidos gastro-resistentes." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2002. http://hdl.handle.net/10183/147657.

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Sistemas monolíticos particulados contendo os constituintes ativos veiculados na forma de grânulos revestidos - pellets - têm recebido crescente atenção nos últimos anos, em função da otimização na biodisponibilidade e segurança na liberação do fármaco. A utilização destas unidades, como componentes de comprimidos traz, como principal vantagem, a divisibilidade da forma sem a perda do perfil biofarmacêutico desejado para o fármaco. Para sua produção, é indispensável a manutenção da integridade do revestimento daquelas unidades. Uma estratégia para o alcance deste objetivo envolve a utilização

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13

Naves, Letícia Nasser. "Desenvolvimento de pellets e comprimidos matriciais de etilcelulose para liberação cólon-específica de fármacos." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/5571.

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Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2016-05-19T12:46:17Z No. of bitstreams: 2 Dissertação - Letícia Nasser Naves - 2014.pdf: 1491625 bytes, checksum: e7abb20b33c04d9858d94938efaab361 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-05-19T13:02:54Z (GMT) No. of bitstreams: 2 Dissertação - Letícia Nasser Naves - 2014.pdf: 1491625 bytes, checksum: e7abb20b33c04d9858d94938efaab361 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>M

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14

Yatsu, Francini Kiyono Jorge. "Desenvolvimento tecnológico de grânulos esferoidais a partir de extrato seco de folhas e ramos de ilex paraguariensis St. Hil. aquifoliaceae (erva-mate)." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/142758.

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O presente trabalho teve como objetivos produzir um extrato seco de Ilex paraguariensis por spray-drying, em escala semi-industrial, e desenvolver grânulos esferoidais a partir do extrato seco, pelo método de extrusão/esferonização, bem como caracterizar as propriedades físicas, químicas e tecnológicas e investigar a estabilidade dos principais constituintes polifenólicos de ambos produtos frente à radiação UVC e ao calor. O extrato seco apresentou partículas esféricas (tamanho médio de 19,6 μm), com superfície lisa, boas propriedades de fluxo e rendimento satisfatório (67 %). No teste de foto

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15

Serpa, Raphael Caixeta. "Desenvolvimento de pellets revestidos para liberação cólon-específica dos polifenóis de Bidens pilosa L." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5381.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-03-24T14:47:46Z No. of bitstreams: 2 Dissertação - Raphael Caixeta Serpa - 2015.pdf: 1683705 bytes, checksum: 7ee9a89fe7a14cfa8fcc536da1ebc46c (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-03-24T14:49:28Z (GMT) No. of bitstreams: 2 Dissertação - Raphael Caixeta Serpa - 2015.pdf: 1683705 bytes, checksum: 7ee9a89fe7a14cfa8fcc536da1ebc46c (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>

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16

Alencar, Rodrigo Gomes de. "Desenvolvimento de comprimidos contendo pellets revestidos para liberação cólon específica de cetoprofeno." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/4020.

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Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2015-01-30T10:47:22Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Dissertação - Rodrigo Gomes de Alencar - 2014.pdf: 13066901 bytes, checksum: 15e26e7a3dde863c6267ef54f83385be (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-01-30T12:58:45Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Dissertação - Rodrigo Gomes de Alencar - 2014.pdf: 13066901 bytes, checksum: 15e26e7a3dde863c6267ef54f83385be

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17

Andreazza, Itamar Francisco. "Desenvolvimento e avaliação de péletes de ácido ascórbico obtidos pela tecnologia de extrusão-esferonização." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-25032014-095739/.

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O objetivo do presente trabalho foi desenvolver e avaliar péletes para compor sistema multiparticulado contendo ácido ascórbico, bem como validar metodologia analítica por cromatografia líquida de alta eficiência (CLAE) para aplicação em ensaio de dissolução destas formas farmacêuticas. A técnica de extrusão-esferonização foi utilizada por ser de fácil aplicação a nível laboratorial e industrial obtendo-se péletes matriciais, compostos de Methocel® K4M, Methocel® K100M e Eudragit® L 100, e péletes de liberação convencionais, para revestimento em leito fluidizado com Kollicoat® SR 30 D como age

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18

Young, Christopher Ryan. "Properties of spherical pellets produced by a hot-melt extrusion and spheronization process." Thesis, 2004. http://hdl.handle.net/2152/1461.

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19

Marques, Carolina Valdez Thomaz Caldeira. "Effects of binder and granulation fluid in pellets produced by extrusion/spheronization technology." Master's thesis, 2014. http://hdl.handle.net/10451/38755.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>The extrusion/spheronization technology has already proved to have great potential for the production of multiparticulate dosage forms. The present work is dedicated to the study of the effects of different binders and different granulation fluids on pellets preparation, as well as in their properties and drug release. In this research, the production of pellets containing mixtures of different amounts (5%, 25% and 45%), of paracetamol or carbamazepine (which were used as mode

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20

Young, Christopher Ryan McGinity James W. "Properties of spherical pellets produced by a hot-melt extrusion and spheronization process." 2004. http://repositories.lib.utexas.edu/bitstream/handle/2152/1461/youngc79127.pdf.

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21

Jadhav, N., M. Gade, N. Salunkhe, and Anant R. Paradkar. "Extrusion-Spheronization of Talc using Microcrystalline Cellulose as a Pellet Aid: Part I." 2014. http://hdl.handle.net/10454/10463.

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No<br>The aims of the present work were to pelletize talc by extrusion-spheronization technique using microcrystalline cellulose (MCC) as a pelletization aid and to study its performance as a neutral substrate for coating. A 32 factorial design was used to study the effect of independent variables (X1, amount of talc, and X2, MCC) on pellet properties.

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22

Knöll, Marcus Hans [Verfasser]. "Enteric coated mucoadhesive micropellets in rotary agglomeration process for wet spheronization / Marcus Hans Knöll." 2007. http://d-nb.info/982846665/34.

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23

Chan, Ya-wen, and 詹雅雯. "Formulation Studies of Delayed Release Pellets Using Extrusion╱Spheronization on Didanosine and Doxycycline Hyclate." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/56495852064346698187.

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碩士<br>嘉南藥理科技大學<br>生物科技研究所<br>95<br>The purpose of this study is to prepare and evaluate enteric coated pellets after extrusion/spheronization. The various formulation variables studied, including pellet size, amount of enteric polymer (coating thickness) and soluble polymer/enteric polymer ratio were found to affect drug release kinetics in various dissolution media. Both Didanosine and Doxycycline Hyclate were used as model drugs. Didanosine (DDI) is known to be effective in the treatment of patients with HIV virus by inhibiting HIV replication. DDI is an acid labile drug, therefore it ha

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24

"The application of coarse particle ethylcellulose and high molecular weight polyethylene oxide in the production of beads by extrusion-spheronization." UNIVERSITY OF THE SCIENCES IN PHILADELPHIA, 2009. http://pqdtopen.proquest.com/#viewpdf?dispub=3349136.

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25

Chukwumezie, Beatrice Nkem. "Statistically designed spheronization and scale-up of ibuprofen microparticulates using the rotor disk fluid-bed technology coating for prolonged release and hard gelatin encapuslation of microparticulates /." 2003. http://etd1.library.duq.edu/theses/available/etd-10102003-103409/.

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