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Journal articles on the topic 'Spicata has demonstrated promising antioxidant'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Shrutika, Akolkar Vaishnavi Adhalrao Geetanjali Bhale Dr. Bhushan Pimple*. "Mentha Spicata – Scent of Wellness: Investigating the Health Benefits of Spearmint (Mentha Spicata) From Ancient Times to Modern Science." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3182–207. https://doi.org/10.5281/zenodo.15463109.

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Mentha spicata, also referred to as Mentha viridis, is a member of the Lamiaceae family of medicinal plants that is valued for its capacity to produce and release secondary metabolites, mainly essential oils. The aerial components of this plant are used by various populations to create tea, and ethnopharmacological surveys carried out globally have revealed that this tisane has a range of effects. These acts are caused by several compounds found in M. spicata, the biological consequences of which have recently been demonstrated through experiments. M. spicata extracts and essential oils were i

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2

Haghmadad Milani, Maryam, Asghar Mohammadi, Sima Panahirad, et al. "Cerium Oxide Nanoparticles (CeO2 NPs) Enhance Salt Tolerance in Spearmint (Mentha spicata L.) by Boosting the Antioxidant System and Increasing Essential Oil Composition." Plants 13, no. 20 (2024): 2934. http://dx.doi.org/10.3390/plants13202934.

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Salinity represents a considerable environmental risk, exerting deleterious effects on horticultural crops. Nanotechnology has recently emerged as a promising avenue for enhancing plant tolerance to abiotic stress. Among nanoparticles, cerium oxide nanoparticles (CeO2 NPs) have been demonstrated to mitigate certain stress effects, including salinity. In the present study, the impact of CeO2 NPs (0, 25, and 100 mg L−1) on various morphological traits, photosynthetic pigments, biochemical parameters, and the essential oil profile of spearmint plants under moderate (50 mM NaCl) and severe (100 mM

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3

Ali-Shtayeh, Mohammed Saleem, Rana Majed Jamous, Salam Yousef Abu Zaitoun, and Iman Basem Qasem. "In-vitro screening of acetylcholinesterase inhibitory activity of extracts from Palestinian indigenous flora in relation to the treatment of Alzheimer’s disease." Functional Foods in Health and Disease 4, no. 9 (2014): 381. http://dx.doi.org/10.31989/ffhd.v4i9.149.

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Background: Cholinesterase inhibitory therapy serves as a strategy for the treatment of Alzheimer’s disease (AD). Several acetylcholinesterase inhibitors (AChEIs) are used for the symptomatic treatment of AD. These compounds have been reported to have adverse effects, including gastrointestinal disturbances. This study was therefore partly aimed at investigating in vitro possible AChEIs in herbal medicines traditionally used in Palestine to treat cognitive disorders, and to point out the role of these plants as potential sources for development of newly potent and safe natural therapeutic agen

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El Menyiy, Naoual, Hanae Naceiri Mrabti, Nasreddine El Omari, et al. "Medicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Mentha spicata." Evidence-Based Complementary and Alternative Medicine 2022 (April 12, 2022): 1–32. http://dx.doi.org/10.1155/2022/7990508.

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Mentha spicata, also called Mentha viridis, is a medicinal plant of the Lamiaceae family characterized by its potency to synthesize and secret secondary metabolites, essentially essential oils. Different populations use the aerial parts of this plant for tea preparation, and this tisane has shown several effects, according to ethnopharmacological surveys carried out in different areas around the world. These effects are attributed to different compounds of M. spicata, in which their biological effects were recently proved experimentally. Pharmacological properties of M. spicata extracts and es

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Zúñiga, Antonio, Claudio A. Sáez, Andrés Trabal, et al. "Seasonal Photoacclimation and Vulnerability Patterns in the Brown Macroalga Lessonia spicata (Ochrophyta)." Water 13, no. 1 (2020): 6. http://dx.doi.org/10.3390/w13010006.

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Fluctuations in solar radiation are one of the key factors affecting productivity and survival in habitat forming coastal macroalgae, in this regard, photoacclimation has a direct impact on the vulnerability and the capacity of seaweed to withstand, for instance, radiation excess. Here, we study ecophysiological responses through photosynthetic activity measurements under time-dependent (one year) fluctuations in solar radiation in the brown macroalga L. spicata. The responses presented seasonal patterns, with an increase in photosynthetic capacity during summer, expressed in greater maximal e

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Pratiksha, Jagtap Vaibhav Changediya. "Formulation Development And Evaluation Of Mentha Spicata Leaf Powder Orodispersible Tablet." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 566–82. https://doi.org/10.5281/zenodo.13920434.

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This research was focuses on the formulation development and evaluation of Oro-dispersible tablets (ODTs) containing Mentha spicata leaf powder, aiming to explore its potential as a novel herbal formulation for oral administration. Mentha spicata, commonly known as spearmint, possesses various pharmacological properties, including antimicrobial, antioxidant, and anti-inflammatory effects, which make it a promising candidate for pharmaceutical applications. The formulation process involves the wet granulation method for Mentha spicata leaf powder tablet. The Tablet was evaluated for its physica

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7

Zekri, Nadia, Hanane Elazzouzi, Atika Ailli, et al. "Physicochemical Characterization and Antioxidant Properties of Essential Oils of M. pulegium (L.), M. suaveolens (Ehrh.) and M. spicata (L.) from Moroccan Middle-Atlas." Foods 12, no. 4 (2023): 760. http://dx.doi.org/10.3390/foods12040760.

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The cosmetics and food fields are based on the use of synthetic substances to protect their products against oxidation. However, synthetic antioxidants were reported to have negative effects on human health. The interest to develop natural antioxidants from plants has been growing in recent decades. The aim of this study was to determine the antioxidant properties of three essential oils (EOs) of M. pulegium (L.), M. suaveolens (Ehrh.) and M. spicata (L.) from the Azrou and Ifrane regions. The organoleptic characteristics, yields and physical properties were determined for the selected EOs. Th

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8

Hafeeza and Sumaiya Kouser. "Fodanj (Mentha Piperita): Clinical applications in medicine and beyond." World Journal of Advanced Research and Reviews 25, no. 2 (2025): 2004–10. https://doi.org/10.30574/wjarr.2025.25.2.0487.

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Background: Fodanj (Mentha Piperita), commonly known as peppermint, is a hybrid species of Mentha aquatica and Mentha spicata from the Lamiaceae family. It is widely cultivated for its medicinal, culinary and aromatic properties. Traditionally, it has been used for respiratory, gastrointestinal and dermatological conditions. Objectives: This study aims to explore the botanical characteristics, chemical composition, pharmacological properties and clinical applications of Mentha Piperita, highlighting its therapeutic potential. Methods: A comprehensive literature review was conducted, compiling

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Magnani, C., V. L. B. Isaac, M. A. Correa, and H. R. N. Salgado. "Caffeic acid: a review of its potential use in medications and cosmetics." Anal. Methods 6, no. 10 (2014): 3203–10. http://dx.doi.org/10.1039/c3ay41807c.

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Besides powerful antioxidant activity, increasing collagen production and prevention of premature aging, caffeic acid has demonstrated antimicrobial activity and may be promising in the treatment of dermal diseases.

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10

Zahin, Maryam, Farrukh Aqil, Fohad Mabood Husain, and Iqbal Ahmad. "Antioxidant Capacity and Antimutagenic Potential ofMurraya koenigii." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/263509.

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It is well known that the intake of antioxidants with increased consumption of fruits and vegetables and medicinal herbs contributes towards reduced risk of certain diseases including cancers. This study aims to evaluate the broad-spectrum antioxidant and antimutagenic activities as well as to elucidate phytochemical profile of an Indian medicinal plantMurraya koenigii(curry) leaves. Leaves of the plant were successively fractionated in various organic solvents. Benzene fraction demonstrated the highest phenolic content followed by petroleum ether. The benzene fraction showed maximum antioxida

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11

Chai, Yuan-yuan, Fang Wang, Yan-li Li, Ke Liu, and Hui Xu. "Antioxidant Activities of Stilbenoids fromRheum emodiWall." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/603678.

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Rheum emodiWall has been reported to possess protective effect in many inflammatory diseases and oxidative stress-related injuries. This study aims to investigate antioxidant power of stilbenoids fromR. emodiand then explore the material basis for its antioxidant potential. The most abundant stilbenoid piceatannol-4′-O-β-D-glucopyranoside (PICG) and its aglycon piceatannol (PICE) were isolated fromR. emodirhizome. Using well-accepted antioxidant chemicals as reference, antioxidant activity of these stilbenoids was examined by measuring DPPH and superoxide anion radical scavenging, ferric reduc

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AlZain, Mashail N., Fawziah M. Albarakaty, and Rehab M. A. El-Desoukey. "An Ethnobotanical, Phytochemical Analysis, Antimicrobial and Biological Studies of Pulicaria crispa as a Graze Promising Shrub." Life 13, no. 11 (2023): 2197. http://dx.doi.org/10.3390/life13112197.

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Due to the global issue of antimicrobial resistance, one of the most significant challenges in microbiological research is to develop a replacement antibiotic with minimal adverse effects. The wild shrub Pulicaria crispa (gethgath) has been traditionally used for camel and ruminant grazing. While prior research has demonstrated its antimicrobial properties against human diseases, no investigations have been conducted on its efficacy against animal pathogens. The objective of this study is to explore the ethnobotanical, phytochemical, antioxidant, anticancer, and antimicrobial activity of Pulic

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Azzeh, Firas S., Waad W. Kamfar, Mazen M. Ghaith, et al. "Unlocking the health benefits of melatonin supplementation: A promising preventative and therapeutic strategy." Medicine 103, no. 38 (2024): e39657. http://dx.doi.org/10.1097/md.0000000000039657.

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Melatonin (MLT) is crucial in controlling human sleep-wake patterns. While it has long been recognized for regulating circadian rhythms, its demonstrated efficacy in managing various diseases has recently gained considerable attention. This review discusses MLT’s potential preventative and therapeutic effects on various diseases. Several studies have focused on examining the molecular mechanisms through which MLT brings about its protective or therapeutic effects on various diseases, including cancer, obesity, coronavirus, and cardiovascular diseases. Numerous preventative and therapeutic appl

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14

Gunenc, Aynur, Christina Alswiti, and Farah Hosseinian. "Wheat Bran Dietary Fiber: Promising Source of Prebiotics with Antioxidant Potential." Journal of Food Research 6, no. 2 (2017): 1. http://dx.doi.org/10.5539/jfr.v6n2p1.

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The potential of wheat bran (WB) addition as a prebiotic source were demonstrated using yogurt with probiotics (Lactobacillus acidophilus and Bifidobacterium lactis). Yogurts (with 4% WB) were significantly (P < 0.05) different in total bacterial counts (9.1 log CFU/mL), and total titratable acidity % (TTA, 1.4%) compared to controls during 28 days cold storage (4°C). Additionally, WB-total dietary fiber contents and their bound phenolic profiles were investigated as well as the antioxidant activity of WB-water extractable polysaccharides (WEP) was studied. HPLC analysis of alkaline hydroly

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15

Di Filippo, Ester Sara, Letizia Giampietro, Barbara De Filippis, et al. "Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents." Molecules 25, no. 23 (2020): 5770. http://dx.doi.org/10.3390/molecules25235770.

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The increased risk of illness and disability is related to the age inevitable biological changes. Oxidative stress is a proposed mechanism for many age-related diseases. The crucial importance of polyphenol pharmacophore for aging process is largely described thanks to its effects on concentrations of reactive oxygen species. Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV) plays a critical role in slowing the aging process but has a poor bioavailabity after oral intake. In this present work, a series of RSV derivatives was designed, synthesized, and evaluated as potential antioxidant agent

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16

Dell’Albani, Paola, Claudia Carbone, Giovanni Sposito, et al. "Effect of Ferulic Acid Loaded in Nanoparticle on Tissue Transglutaminase Expression Levels in Human Glioblastoma Cell Line." International Journal of Molecular Sciences 25, no. 15 (2024): 8397. http://dx.doi.org/10.3390/ijms25158397.

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Glioblastoma (GBM) is one of the most aggressive cancers, characterized by a decrease in antioxidant levels. Evidence has demonstrated that ferulic acid (FA), a natural antioxidant particularly abundant in vegetables and fruits, could be a promising candidate for GBM treatment. Since FA shows a high instability that compromises its therapeutic application, it has been encapsulated into Nanostructured Lipid Carriers (NLCs) to improve its bioavailability in the brain. It has been demonstrated that tissue transglutaminase (TG2) is a multi-functional protein implicated in many physiological and pa

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17

Elizondo-Luevano, Joel H., Ramiro Quintanilla-Licea, Imelda N. Monroy-García, et al. "Assessment of Anticancer Properties of Argemone mexicana L. and Berberine: A Comparative Study." Plants 13, no. 10 (2024): 1374. http://dx.doi.org/10.3390/plants13101374.

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Argemone mexicana L. has been used in traditional Mexican medicine. Among its bioactive constituents, berberine (BER) has garnered attention for its cytotoxic properties against different tumor cell lines. This study investigates the in vitro toxicity against HEP-G2 (human hepatocellular carcinoma) and murine lymphoma (L5178Y-R) cells using the MTT assay of the methanol extract (AmexM), sub-partitions of A. mexicana, and BER. Selectivity indices (SIs) were determined by comparing their cytotoxic effects on VERO (monkey kidney epithelial) and PBMC (human peripheral blood mononuclear) non-tumora

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18

Arriagada, Francisco, Germán Günther, and Javier Morales. "Nanoantioxidant–Based Silica Particles as Flavonoid Carrier for Drug Delivery Applications." Pharmaceutics 12, no. 4 (2020): 302. http://dx.doi.org/10.3390/pharmaceutics12040302.

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Nanosystems used in pharmaceutical formulations have shown promising results in enhancing the administration of drugs of difficult formulations. In particular, porous silica nanoparticles have demonstrated excellent properties for application in biological systems; however, there are still several challenges related to the development of more effective and biocompatible materials. An interesting approach to enhance these nanomaterials has been the development of nanoantioxidant carriers. In this work, a hybrid nanoantioxidant carrier based on porous silica nanoplatform with rosmarinic acid ant

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Jiménez-Cabrera, Tania, Mirandeli Bautista, Claudia Velázquez-González, et al. "Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?" International Journal of Molecular Sciences 22, no. 1 (2020): 248. http://dx.doi.org/10.3390/ijms22010248.

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The negative impact that oxidative stress has on health is currently known. The complex mechanism of free radicals initiates a series of chain reactions that contribute to the evolution or development of different degenerative disorders. Likewise, these disorders are usually accompanied by inflammatory processes and, therefore, pain. In this sense, reactive oxygen species (ROS) have been shown to promote the nociceptive process, but effective treatment of pain and inflammation still represents a challenge. Over time, it has been learned that there is no single way to relieve pain, and as long

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20

Cunha, Luciano B., Eloah D. Lepore, Camila Cristina B. Medeiros, Rodrigo Sorrechia, Rosemeire C. L. R. Pietro, and Marcos A. Corrêa. "Can Gentisic Acid Serve as a High-Performance Antioxidant with Lower Toxicity for a Promising New Topical Application?" Life 14, no. 8 (2024): 1022. http://dx.doi.org/10.3390/life14081022.

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Gentisic acid (2,5-dihydroxybenzoic acid) is primarily found naturally in plants and has demonstrated a significant range of biological activities; however, its efficacy and safety as a topical application ingredient are not yet well established. Thus, the compound’s potential antioxidant and antimicrobial properties were evaluated for efficacy, while the cytotoxicity was evaluated for safety. The antioxidant activity, measured by the DPPH kinetic method, showed an Efficiency Concentration (EC50) of 0.09 with an antioxidant reducing power (ARP) of 11.1. The minimum inhibitory concentration (MI

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Silvestro, Serena, and Emanuela Mazzon. "Nrf2 Activation: Involvement in Central Nervous System Traumatic Injuries. A Promising Therapeutic Target of Natural Compounds." International Journal of Molecular Sciences 24, no. 1 (2022): 199. http://dx.doi.org/10.3390/ijms24010199.

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Central nervous system (CNS) trauma, such as traumatic brain injury (TBI) and spinal cord injury (SCI), represents an increasingly important health burden in view of the preventability of most injuries and the complex and expensive medical care that they necessitate. These injuries are characterized by different signs of neurodegeneration, such as oxidative stress, mitochondrial dysfunction, and neuronal apoptosis. Cumulative evidence suggests that the transcriptional factor nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial defensive role in regulating the antioxidant response

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22

Zhou, Kequan, and Julian J. Raffoul. "Potential Anticancer Properties of Grape Antioxidants." Journal of Oncology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/803294.

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Dietary intake of foods rich in antioxidant properties is suggested to be cancer protective. Foods rich in antioxidant properties include grape (Vitis vinifera), one of the world’s largest fruit crops and most commonly consumed fruits in the world. The composition and cancer-protective effects of major phenolic antioxidants in grape skin and seed extracts are discussed in this review. Grape skin and seed extracts exert strong free radical scavenging and chelating activities and inhibit lipid oxidation in various food and cell modelsin vitro. The use of grape antioxidants are promising against

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23

Markowska, Julia, Kamila Kasprzak-Drozd, Przemysław Niziński, et al. "Quercetin: A Promising Candidate for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)." Molecules 29, no. 22 (2024): 5245. http://dx.doi.org/10.3390/molecules29225245.

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Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a chronic liver disease. The development of MASLD is influenced by a multitude of diseases associated with modern lifestyles, including but not limited to diabetes mellitus, hypertension, hyperlipidaemia and obesity. These conditions are often consequences of the adoption of unhealthy habits, namely a sedentary lifestyle, a lack of physical activity, poor dietary choices and excessive alcohol consumption. The treatment of MASLD is primarily based on modifying the patient’s lifestyle and pharmacological intervention. De

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Chintong, Sutasinee, Wipaporn Phatvej, Ubon Rerk-Am, Yaowapha Waiprib, and Wanwimol Klaypradit. "In Vitro Antioxidant, Antityrosinase, and Cytotoxic Activities of Astaxanthin from Shrimp Waste." Antioxidants 8, no. 5 (2019): 128. http://dx.doi.org/10.3390/antiox8050128.

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Astaxanthin is a potent antioxidant compared with vitamins and other antioxidants. However, astaxanthin extract from shrimp processing waste has not yet been used in cosmetic products. This study aimed to explore the natural astaxanthin from shrimp shells for antioxidant and antityrosinase activities as well as potential toxicity. The antioxidant activities were performed with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, β-carotene bleaching, and singlet oxygen quenching assays. The results revealed that astaxanthin ext

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OSPINA Giraldo, Luis Fernando, Diana M. ARAGÓN, Nadezdha E. VERGEL, Gustavo ISAZA, and Jorge E. PEREZ. "ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF <I>PHENAX rugosus</I> (POIR.) WEDD AND <I>TABEBUIA chrysanta</I> G. NICHOLSON." Vitae 18, no. 1 (2011): 49–55. http://dx.doi.org/10.17533/udea.vitae.6603.

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The inflammation is a multifactorial and highly regulated process associated to several chronic and degenerative diseases. Due to a lot of inflammatory process are sometimes characterized by oxidative stress, it has been demonstrated that antioxidants are useful as anti-inflammatory agents. The species Phenax rugosus (Poir.) Wedd and Tabebuia chrysanta G. Nicholson are used in the “Eje Cafetero” of Colombia by their antiinfeccious and immunomodulatory properties. In this work we evaluate in vivo anti-inflammatory and in vitro antioxidant properties of these plant species. We use two acute infl

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SINGH, NIHARIKA. "Analysis of Antioxidant and Antibacterial properties of Bauhinia variegata and Sarcostemma acidum through scavenging process." Annals of Plant and Soil Research 26, no. 2 (2024): 333–40. http://dx.doi.org/10.47815/apsr.2024.10368.

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The traditional use of chemical-based antimicrobial substances has adverse effects on human health. Consequently, there is a growing demand for alternative antimicrobial agents sourced from natural origins that are potentially effective and safe for human consumption. Primary aim of this research is to explore the antioxidant and antibacterial properties of leaf extracts from Bauhinia variegata and stem extract from Sarcostemma acidum, along with determining their phenolic content. The sample extracts of both the plants were evaluated for antioxidant properties using DPPH radical scavenging ac

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Miya, Gugulethu M., Ayodeji O. Oriola, Pallab Kar, and Adebola O. Oyedeji. "Isolation and characterization of fatty acid esters from Cyperus marginatus Thunb. leaf, their in vitro biological and in silico molecular docking studies." Journal of Pharmacy & Pharmacognosy Research 13, s1 (2025): S27—S46. https://doi.org/10.56499/jppres24.2109_13.s1.27.

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Context: Fatty acid esters (FAEs) are a unique class of secondary metabolites with promising antioxidant and anti-inflammatory properties, making them useful ingredients for cosmetic formulations. So far, many plants in the Cyperus genus (family Cyperaceae) are known to contain FAEs, among other classes of phytochemicals. However, Cyperus marginatus (CM) is one of the under-investigated species in this genus. Aims: To evaluate CM for its antioxidant (AOX) and anti-inflammatory FAEs. Methods: Two FAEs were isolated from CM leaf dichloromethane extract by silica gel column chromatography, while

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Lopes Hornai, Ermelinda Maria Lopes, Murat Aycan, and Toshiaki Mitsui. "The Promising B−Type Response Regulator hst1 Gene Provides Multiple High Temperature and Drought Stress Tolerance in Rice." International Journal of Molecular Sciences 25, no. 4 (2024): 2385. http://dx.doi.org/10.3390/ijms25042385.

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High temperatures, drought, and salt stresses severely inhibit plant growth and production due to the effects of climate change. The Arabidopsis ARR1, ARR10, and ARR12 genes were identified as negative salt and drought stress regulators. However, in rice, the tolerance capacity of the hst1 gene, which is orthologous to the ARR1, ARR10, and ARR12 genes, to drought and multiple high temperature and drought stresses remains unknown. At the seedling and reproductive stages, we investigated the drought (DS) high temperature (HT) and multiple high temperature and drought stress (HT+DS) tolerance cap

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Gopinatth, Varun, Rufa L. Mendez, Elaine Ballinger, and Jung Yeon Kwon. "Therapeutic Potential of Tuna Backbone Peptide and Its Analogs: An In Vitro and In Silico Study." Molecules 26, no. 7 (2021): 2064. http://dx.doi.org/10.3390/molecules26072064.

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Tuna backbone peptide (TBP) has been reported to exert potent inhibitory activity against lipid peroxidation in vitro. Since this bears relevant physiological implications, this study was undertaken to assess the impact of peptide modifications on its bioactivity and other therapeutic potential using in vitro and in silico approach. Some TBP analogs, despite lower purity than the parent peptide, exerted promising antioxidant activities in vitro demonstrated by ABTS radical scavenging assay and cellular antioxidant activity assay. In silico digestion of the peptides resulted in the generation o

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Luo, Donghui, Dingding Shi, and Lingrong Wen. "From Epimedium to Neuroprotection: Exploring the Potential of Wushanicaritin." Foods 13, no. 10 (2024): 1493. http://dx.doi.org/10.3390/foods13101493.

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Epimedium has been used for functional foods with many beneficial functions to human health. Wushanicaritin is one of the most important chemicals int Epimedium. This study investigated the neuroprotective effects of wushanicaritin and potential underlying mechanisms. The results demonstrated that wushanicaritin possessed superior intercellular antioxidant activity compared to icaritin. Wushanicaritin, with an EC50 value of 3.87 μM, showed better neuroprotective effect than quercetin, a promising neuroprotection agent. Wushanicaritin significantly reversed lactate dehydrogenase release, reacti

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Dong, Hui, Mingfei Liu, Li Wang, et al. "Bromophenol Bis (2,3,6-Tribromo-4,5-dihydroxybenzyl) Ether Protects HaCaT Skin Cells from Oxidative Damage via Nrf2-Mediated Pathways." Antioxidants 10, no. 9 (2021): 1436. http://dx.doi.org/10.3390/antiox10091436.

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Excessive reactive oxygen species (ROS) promotes the oxidative stress of keratinocytes, eventually causing cell damage. The natural bromophenol bis (2,3,6-tribromo-4,5-dihydroxybenzyl) ether (BTDE) from marine red algae has been reported to have a varied bioactivity; however, its antioxidant effect has yet to be investigated systemically. Our present work aimed to explore the antioxidant effect of BTDE both on the molecular and cellular models and also to illustrate the antioxidant mechanisms. Our results showed that BTDE could effectively scavenge ABTS free radicals and protect HaCaT cells fr

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Narayanaswamy, Radhakrishnan, and Norhaizan Mohd Esa. "PHYTIC ACID (MYO-INOSITOL HEXAPHOSPHATE)- A PROMISING PHARMACEUTICAL AGENT: A REVIEW." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (2018): 42. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.27843.

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Phytic acid (myo-inositol hexaphosphate) has gained much attention among researchers for its therapeutic value. This review focuses on pharmacological activities of phytic acid, which have been demonstrated by pre-clinical studies. Anti-carcinogenic, antioxidant, antidiabetic, hypolipidemic, anti-angiogenic, and immunomodulation are the most extensively studied pharmacological activities of phytic acid. In addition to these, phytic acid and its derivatives also possess enzyme inhibitory activities against few key enzymes such as 5-alpha reductase, aldose reductase, cyclooxygenase, lipase, matr

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Linh Tran, Chi, Van Mai Do, Van Truong Huynh, Van Ky Nguyen, and Kim Thien Duc Chong. "Antioxidant and anti-diabetic effects in vitro of extract from the above-ground parts of Acanthus ilicifolius." Bionatura Journal 1, no. 3 (2024): 1–16. http://dx.doi.org/10.70099/bj/2024.01.03.4.

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The in vitro antioxidant and anti-diabetic activity of the extract from the above-ground parts of Acanthus ilicifolius was evaluated to assess the potential of this plant as a probable natural medicinal source for diseasetreatment. The aqueous extract from the above-ground parts of this plant demonstrated the existence of alkaloids, polyphenols, flavonoids, steroids, triterenes, tannins, saponins, and glycosides, providing promising results in all the tests performed. The antioxidant activity of A. ilicifolius's above-ground parts extract was graded by five methods, including total antioxidant

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Dogara, Abdulrahaman Mahmoud, Sawsan Sadiq Al-Rawi, Ateeq Ahmed Al-Zahrani, et al. "Biological Activities, Chemical Composition and Molecular Docking of Urelytrum giganteum Pilg." Acta Chimica Slovenica 72, no. 1 (2025): 107–18. https://doi.org/10.17344/acsi.2024.9077.

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The growing interest in health-promoting food options has highlighted the need to explore new sources with unique nutritional compositions. Plants are rich sources of bioactive compounds with biological effects. Urelytrum giganteum Pilg is a perennial wild tufted grass that grows in dry tropical African countries. Traditionally, it has been used to treat several diseases, however, up to date, no study has been done on this plant. This study analyzed the solvent extraction of Urelytrum giganteum Pilg, a perennial wild tufted grass in dry tropical African countries, to determine its proximate an

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Spasov, Alexander A., Aida F. Kucheryavenko, Ksenia A. Gaidukova, Vadim A. Kosolapov, and Olga N. Zhukovskaya. "Antiplatelet activity of new derivatives of benzimidazole containing sterically hindered phenolic group in their structure." Research Results in Pharmacology 6, no. 1 (2020): 1–9. http://dx.doi.org/10.3897/rrpharmacology.6.50373.

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Introduction: Cardiovascular diseases are currently the leading cause of global disability and mortality. According to the centers for disease control and prevention, the average life expectancy of a person would be 10 years longer but for a high prevalence of cardiovascular diseases, and if antiplatelet drugs and special therapy were used. Materials and methods: Antiplatelet activity of the novel benzimidazole derivatives containing a sterically hindered phenolic group in their structure has been investigated in vitro, using a model of ADP-induced platelet aggregation of rabbit’s plasma. The

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Spasov, Alexander A., Aida F. Kucheryavenko, Ksenia A. Gaidukova, Vadim A. Kosolapov, and Olga N. Zhukovskaya. "Antiplatelet activity of new derivatives of benzimidazole containing sterically hindered phenolic group in their structure." Research Results in Pharmacology 6, no. (1) (2020): 1–9. https://doi.org/10.3897/rrpharmacology.6.50373.

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Introduction: Cardiovascular diseases are currently the leading cause of global disability and mortality. According to the centers for disease control and prevention, the average life expectancy of a person would be 10 years longer but for a high prevalence of cardiovascular diseases, and if antiplatelet drugs and special therapy were used. Materials and methods: Antiplatelet activity of the novel benzimidazole derivatives containing a sterically hindered phenolic group in their structure has been investigated in vitro, using a model of ADP-induced platelet aggregation of rabbit's plasma. The

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Mota, Inês F., Filipa Antunes, Joana F. Fangueiro, et al. "Sugarcane Light-Colored Lignin: A Renewable Resource for Sustainable Beauty." International Journal of Molecular Sciences 24, no. 21 (2023): 15941. http://dx.doi.org/10.3390/ijms242115941.

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Lignin has emerged as a promising eco-friendly multifunctional ingredient for cosmetic applications, due to its ability to protect against ultraviolet radiation and its antioxidant and antimicrobial properties. However, its typical dark color and low water solubility limit its application in cosmetics. This study presents a simple process for obtaining light-colored lignin (LCLig) from sugarcane bagasse (SCB) alkaline black liquor, involving an oxidation treatment with hydrogen peroxide, followed by precipitation with sulfuric acid. The physico-chemical characterization, antioxidant and emulsi

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Banshoya, Kengo, Aoi Machida, Saki Kawamura, et al. "Development of a Water-Soluble Nanomicellar Formulation Loaded with Trans-Resveratrol Using Polyethylene Glycol Monostearate for the Treatment of Intracerebral Hemorrhage." Pharmaceutics 16, no. 11 (2024): 1462. http://dx.doi.org/10.3390/pharmaceutics16111462.

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Background/Objectives: Trans-resveratrol (Res) has been reported to possess many biological activities, including neuroprotective effects, owing to its anti-inflammatory and antioxidant properties. However, Res has very low water solubility, which limits its therapeutic application. In this work, we formulated water-soluble micellar formulations incorporating Res using polyethylene glycol monostearate (stPEG). Methods: These formulations (stPEG/Res) were developed using five types of stPEG containing 10, 25, 40, 55 and 140 PEG repeat units. The formulations were characterized for Res content,

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Albarakaty, Fawziah M., Mashail N. AlZain, and Rehab M. A. El-Desoukey. "An Examination of the Ethnobotanical, Phytochemical, Antimicrobial, and Biological Properties of Zygophyllum coccineum, Emphasizing Its Potential as a Valuable Forage Shrub." Life 15, no. 4 (2025): 661. https://doi.org/10.3390/life15040661.

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The growing issue of antimicrobial resistance poses a significant challenge for microbiological research, driving the need for alternative antibiotics with minimal side effects. Zygophyllum coccineum, commonly referred to as “Tebtab” in Arabic and “Red Spinepod” in English, has traditionally been utilized as forage for camels and ruminants. While its antimicrobial activity against human pathogens has been documented, its efficacy against animal pathogens remains underexplored. This study aims to evaluate the phytochemical composition, biological activities, and antimicrobial potential of water

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Xi, Qilemuge, Hao Wang, Liuxi Yi, et al. "ANPrAod: Identify Antioxidant Proteins by Fusing Amino Acid Clustering Strategy and N -Peptide Combination." Computational and Mathematical Methods in Medicine 2021 (April 8, 2021): 1–10. http://dx.doi.org/10.1155/2021/5518209.

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Antioxidant proteins perform significant functions in disease control and delaying aging which can prevent free radicals from damaging organisms. Accurate identification of antioxidant proteins has important implications for the development of new drugs and the treatment of related diseases, as they play a critical role in the control or prevention of cancer and aging-related conditions. Since experimental identification techniques are time-consuming and expensive, many computational methods have been proposed to identify antioxidant proteins. Although the accuracy of these methods is acceptab

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Pyrgioti, Elisavet, Konstantia Graikou, Antigoni Cheilari, and Ioanna Chinou. "Assessment of Antioxidant and Antimicrobial Properties of Selected Greek Propolis Samples (North East Aegean Region Islands)." Molecules 27, no. 23 (2022): 8198. http://dx.doi.org/10.3390/molecules27238198.

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Propolis is a bee-produced substance rich in bioactive compounds, which has been utilized widely in folk medicine, in food supplement and cosmetology areas because of its biological properties, (antibacterial, antiviral, antioxidant, anti-inflammatory, etc.). The subject of this study is associated with the chemical analysis and the biological evaluation of 16 propolis samples from the northeast Aegean region Greek islands, a well-recognized geographic area and the homeland of rich flora as a crossroads between Europe and Asia. Our study resulted in the detection of a significant percentage of

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Gao, Ping, Xue Xiao, Xiao Cui, Hong Zhang, and Xuelan Gu. "Lysine Carboxymethyl Cysteinate, as a Topical Glutathione Precursor, Protects Against Oxidative Stress and UVB Radiation-Induced Skin Damage." Antioxidants 14, no. 5 (2025): 606. https://doi.org/10.3390/antiox14050606.

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Lysine carboxymethyl cysteinate (LCC) is a synthetic substance obtained via lysine salification of S-carboxymethyl-cysteine. LCC has emerged as a promising glutathione (GSH) precursor. In this study, we sought to determine whether LCC could boost GSH levels and protect skin against oxidative stress. Experiments utilizing primary human keratinocytes and skin tissue samples revealed that LCC significantly increased endogenous GSH levels. LCC was able to pass through the stratum corneum and reach deep into the epidermis, where it enhanced the production of key metabolites involved in GSH biosynth

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Huguet-Casquero, Amaia, Maria Moreno-Sastre, Tania Belén López-Méndez, Eusebio Gainza, and Jose Luis Pedraz. "Encapsulation of Oleuropein in Nanostructured Lipid Carriers: Biocompatibility and Antioxidant Efficacy in Lung Epithelial Cells." Pharmaceutics 12, no. 5 (2020): 429. http://dx.doi.org/10.3390/pharmaceutics12050429.

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Oxidative damage has been linked to a number of diseases. Oleuropein (OLE), a natural occurring polyphenol from olive leaves (Olea europaea L.), is known to be a potent antioxidant compound with inherent instability and compromised bioavailability. Therefore, in this work, nanostructured lipid carriers (NLCs) were proposed for OLE encapsulation to protect and improve its antioxidant efficacy. The lipid matrix, composed of olive oil and Precirol, was optimized prior to OLE encapsulation. The characterization of the optimized oleuropein-loaded NLCs (NLC-OLE) showed a mean size of 150 nm, a zeta

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Isaev, Nickolay K., Elizaveta E. Genrikhs, and Elena V. Stelmashook. "Antioxidant Thymoquinone and Its Potential in the Treatment of Neurological Diseases." Antioxidants 12, no. 2 (2023): 433. http://dx.doi.org/10.3390/antiox12020433.

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Oxidative stress is one of the main pathogenic factors of neuron damage in neurodegenerative processes; this makes it an important therapeutic target to which the action of neuroprotectors should be directed. One of these drugs is thymoquinone. According to modern data, this substance has a wide range of pharmacological activity, including neuroprotective, which was demonstrated in experimental modeling of various neurodegenerative diseases and pathological conditions of the brain. The neuroprotective effect of thymoquinone is largely due to its antioxidant ability. Currently available data sh

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Ghosh, Priyanka, Tiyasa Dey, Romit Majumder, Madhuri Datta, Aindrila Chattopadhyay, and Debasish Bandyopadhyay. "Melatonin attenuates cardiac injury caused by chromium-mediated oxidative stress in male Wistar rats: involvement of antioxidative mechanisms." Melatonin Research 6, no. 1 (2023): 79–101. http://dx.doi.org/10.32794/mr112500143.

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Cardiovascular disease (CVD) is a global health concern due to its high mortality. Heavy metals are the potential risk factor for CVD. Among other heavy metals, chromium (Cr) is considered a serious threat to human health due to its high oxidative capacity. In the current study, male Wistar rats were treated with Cr to induce cardiac tissue injuries, meanwhile, melatonin was given to test whether this treatment can protect against Cr-induced cardiac damage. The results showed that Cr markedly altered the heart weight, biomarkers of oxidative stress, activities of antioxidant and pro-oxidant en

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Negasa, Jiregna Gari. "Dietary plant flavonoid supplementation for poultry as a potent scavenger of hydroxyl radicals and antioxidants: a review." PeerJ Organic Chemistry 6 (March 26, 2024): e9. http://dx.doi.org/10.7717/peerj-ochem.9.

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The poultry industry is paying more attention to plant-based feed additives. Flavonoids are plant secondary metabolites derived from fruits, grains, vegetables, herbs, and medicinal plants. One of the most significant environmental stressors affecting the poultry industry worldwide is heat stress, which lowers the quality and safety of production. An imbalance between the production of free radicals and the body’s natural antioxidant defenses leads to oxidative stress in cells. These reactive species can damage proteins, lipids, DNA, and cellular structures. Improving the antioxidant status of

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Liu, Jian, Sibusiso Luthuli, Qifang Wu, Mingjiang Wu, Jong-il Choi, and Haibin Tong. "Pharmaceutical and Nutraceutical Potential Applications of Sargassum fulvellum." BioMed Research International 2020 (October 14, 2020): 1–12. http://dx.doi.org/10.1155/2020/2417410.

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Sargassum fulvellum is a brown seaweed of the Sargassaceae family which has been demonstrated to exhibit antipyretic, analgesic, antiedema, antimicrobial, antioxidant, antitumor, neuroprotective, anticoagulative, anti-inflammatory, and hepatoprotective activities. It has been widely used as a food additive and as a medicine in oriental medicine to treat lumps, dropsy, swelling, testicular pains, and urinary problems. S. fulvellum has been identified as a potential producer of a wide spectrum of natural compounds such as carotenoids, fucoidans, and phlorotannins, showing different biological ac

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Luca, Maria, Antonina Luca, and Carmela Calandra. "The Role of Oxidative Damage in the Pathogenesis and Progression of Alzheimer’s Disease and Vascular Dementia." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/504678.

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Oxidative stress (OS) has been demonstrated to be involved in the pathogenesis of the two major types of dementia: Alzheimer’s disease (AD) and vascular dementia (VaD). Evidence of OS and OS-related damage in AD is largely reported in the literature. Moreover, OS is not only linked to VaD, but also to all its risk factors. Several researches have been conducted in order to investigate whether antioxidant therapy exerts a role in the prevention and treatment of AD and VaD. Another research field is that pertaining to the heat shock proteins (Hsps), that has provided promising findings. However,

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Wen, Peng, Teng-Gen Hu, Yan Wen, et al. "Development of Nervilia fordii Extract-Loaded Electrospun PVA/PVP Nanocomposite for Antioxidant Packaging." Foods 10, no. 8 (2021): 1728. http://dx.doi.org/10.3390/foods10081728.

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An ethyl acetate extract from of Nervilia fordii (NFE) with considerable suppression activity on lipid peroxidation (LPO) was first obtained with total phenolic and flavonoid contents and anti-LPO activity (IC50) of 86.67 ± 2.5 mg GAE/g sample, 334.56 ± 4.7 mg RE/g extract and 0.307 mg/mL, respectively. In order to improve its stability and expand its application in antioxidant packaging, the nano-encapsulation of NFE within poly(vinyl alcohol) (PVA) and polyvinyl(pyrrolidone) (PVP) bio-composite film was then successfully developed using electrospinning. SEM analysis revealed that the NFE-loa

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Astrain-Redin, Nora, Irene Talavera, Esther Moreno, et al. "Seleno-Analogs of Scaffolds Resembling Natural Products a Novel Warhead toward Dual Compounds." Antioxidants 12, no. 1 (2023): 139. http://dx.doi.org/10.3390/antiox12010139.

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Nowadays, oxidative cell damage is one of the common features of cancer and Alzheimer’s disease (AD), and Se-containing molecules, such as ebselen, which has demonstrated strong antioxidant activity, have demonstrated well-established preventive effects against both diseases. In this study, a total of 39 Se-derivatives were synthesized, purified, and spectroscopically characterized by NMR. Antioxidant ability was tested using the DPPH assay, while antiproliferative activity was screened in breast, lung, prostate, and colorectal cancer cell lines. In addition, as a first approach to evaluate th

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