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Journal articles on the topic 'Spiked Pharmaceutical Liquid Waste'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Trucillo, Paolo, Roberta Campardelli, and Iolanda De Marco. "Environmental and Sustainability Analysis of a Supercritical Carbon Dioxide-Assisted Process for Pharmaceutical Applications." Processes 9, no. 10 (2021): 1788. http://dx.doi.org/10.3390/pr9101788.

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Drug delivery systems (DDS) are artificial devices employed to enhance drug bioavailability during administration to a human body. Among DDS, liposomes are spherical vesicles made of an aqueous core surrounded by phospholipids. Conventional production methods are characterized by several drawbacks; therefore, Supercritical assisted Liposome formation (SuperLip) has been developed to overcome these problems. Considering that the use of high pressures involves high energy cost, in this paper, sustainability indicators were calculated to quantitatively evaluate the emissions related to the attain

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2

SÜsÜl, İncilay, and Sacide AltinÖz. "A Reversed-Phase High-Performance Liquid Chromatographic Method for the Determination of Zafirlukast in Pharmaceutical Formulations and Human Plasma." Journal of AOAC INTERNATIONAL 89, no. 6 (2006): 1557–64. http://dx.doi.org/10.1093/jaoac/89.6.1557.

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Abstract Zafirlukast (ZAF) is a leukotriene receptor antagonist used in the treatment of chronic asthma. In this study, a simple and sensitive reversed-phase, high-performance liquid chromatographic method was developed for the determination of ZAF in pharmaceutical formulations and human plasma. Piribedil was used as an internal standard. Analysis was carried out on a Nucleosil C18 100 Å(150 × mm 4.6 mm id, 5 ωm) column with acetonitrilepH 3.0 acetate buffer (70 30, v/v) as the mobile phase at a flow rate of 0.8 mL/min. The peak was detected by an ultraviolet detector set at a wavelength of 2

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Ni, Baoxia, Jin Ye, Zhihong Xuan, et al. "Automatic Pretreatment of Dispersive Liquid Liquid Microextraction Based on Immunomagnetic Beads Coupled with UPLC-FLD for the Determination of Zearalenone in Corn Oils." Toxins 15, no. 5 (2023): 337. http://dx.doi.org/10.3390/toxins15050337.

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Sample pretreatment is a vital step in the detection of mycotoxins, and traditional pretreatment methods are time-consuming, labor-intensive and generate much organic waste liquid. In this work, an automatic, high-throughput and environmentally friendly pretreatment method is proposed. Immunomagnetic beads technology and dispersive liquid–liquid microextraction technology are combined, and the zearalenone in corn oils is directly purified and concentrated under the solubilization effects of surfactant. The proposed pretreatment method allows for the batch pretreatment of samples without pre-ex

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Ceccon, Luciano, Debora Saccù, Giuseppe Procida, and Stefano Cardinali. "Liquid Chromatographic Determination of Simple Phenolic Compounds in Waste Waters from Olive Oil Production Plants." Journal of AOAC INTERNATIONAL 84, no. 6 (2001): 1739–44. http://dx.doi.org/10.1093/jaoac/84.6.1739.

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Abstract A method was developed for the determination of simple phenolic compounds (PCs) in waste waters from olive oil production plants by liquid chromatography (LC). The sample under examination was acidified to pH 2 to precipitate proteins, acetone was added to eliminate the colloidal fraction, and hexane was used for extraction to eliminate lipidic substances. The solution obtained was filtered and injected into the LC system; the wavelength selected for the spectrophotometric detection was specific for PCs, so that carbohydrates, organic acids, and short-chain free fatty acids did not in

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Faizee, A., S. S. Sonawane, A. S. Patil, S. J. Kshirsagar, and V. S. Gade. "DEVELOPMENT OF LIQUID-LIQUID EXTRACTION PROCEDURE AND ITS APPLICATION FOR QUANTIFICATION OF ERLOTINIB IN SPIKED HUMAN PLASMA USING RP-HPLC WITH UV DETECTION." INDIAN DRUGS 53, no. 06 (2016): 46–50. http://dx.doi.org/10.53879/id.53.06.10498.

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A simple, rapid and accurate RP-HPLC method was developed and validated for the quantification of Erlotinib in spiked human plasma using liquid-liquid extraction. Sufficient recovery was obtained when drug and internal standard (Nabumetone) were extracted using ethyl acetate and 1N NaOH. Chromatographic separation was performed on C18 Phenomenex Hyperclone column (250 × 4.6 mm, 5 μm) using mobile phase acetonitrile: 20 mM ammonium acetate buffer pH 4.6 (60:40%,V/V). Flow rate was kept constant at 1 mL/min and detection was carried out at 331 nm. Calibration curve was found to be linear in the

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Abed, Sadeem Subhi, and Mayasa Mansour Mohammed. "Spectrophotometric and cloud point extraction methods to detect Quercetin Dihydrate in supplement formulations and urine samples." Ukrainian Journal of Nephrology and Dialysis, no. 4(84) (October 15, 2024): 75–85. https://doi.org/10.31450/ukrjnd.4(84).2024.09.

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The accurate detection and quantification of quercetin dihydrate (QRC) are vital for quality control, pharmacokinetic studies, and bioavailability assessments in pharmaceutical and biological samples. This study aimed to develop and validate a cloud point extraction (CPE) method combined with spectrophotometry for the sensitive and environmentally friendly detection and quantification of QRC in pharmaceutical formulations and spiked urine samples. Methods. The CPE method employed Triton X-114 as a non-ionic surfactant to extract QRC from samples. The extraction process was optimized by evaluat

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Soesanto, Loekas Loekas Soesanto, Alvin Adhyatputera Ramadhana, Endang Mugiastuti, and Abdul Manan. "Effect of Four Liquid Organic Wastes on The Growth of Four Trichoderma harzianum Isolates and Their Effect on Cucumber Growth and Yield." SINTA Journal (Science, Technology, and Agricultural) 2, no. 2 (2022): 19–30. http://dx.doi.org/10.37638/sinta.2.2.19-30.

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The aim of this research was to determine the effect of fourliquid organic substrates on the growth of four Trichoderma harzianum isolates and their effect on cucumber growth and yield. Randomized block design was used with 20 treatments and 3 replicates. The treatments consisted of control, tofu liquid waste, rice washing water, coconut water, and tapioca waste substrates each combined with four T. harzianum isolates. Variables observed were conidia density during decomposition, conidia late density, crop height, root length, root fresh and dry weight, crop fresh and dry weight, the first flo

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Tarek, Mohamed, Hebatallah A. Wagdy, Eman S. Elzanfaly, and Sawsan M. Amer. "A Validated Ultra-Performance Liquid Chromatographic Method for the Simultaneous Determination of Nadifloxacin, Mometasone Furoate and Miconazole Nitrate in Their Combined Dosage Form and Spiked Human Plasma Samples." Journal of Chromatographic Science 57, no. 10 (2019): 867–73. http://dx.doi.org/10.1093/chromsci/bmz082.

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Abstract Nadifloxacin, mometasone furoate and miconazole nitrate are formulated together as a topical antifungal dosage form. In this work, a reversed-phase ultra-performance liquid chromatographic method coupled with a diode array detector (RP-UPLC-DAD) was developed and validated to determine nadifloxacin, mometasone furoate and miconazole nitrate simultaneously in their bulk powder, in pharmaceutical preparation and in spiked human plasma samples. Separation was achieved on an ACQUITY UPLC C18 column of 2.2 μm particle size (2.1 × 100 mm) via isocratic elution using a mobile phase consistin

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Pradnya, Lahupanchang* Shubham Tikait Dr. Swati Deshmukh. "Awareness Of Pharmaceutical Waste Management by Drug Reclamation Program." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2633–44. https://doi.org/10.5281/zenodo.15431403.

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Wastes are the unwanted or unusable materials that people will no longer use for, which are either intended to get rid of or have already been discarded. Moreover, wastes can be hazardous to human or the environment as such, which has to be discarded immediately, else may cause serious health related problems in human. Biomedical waste means any solid or liquid waste which is generated during the diagnosis, treatment or immunization of human beings or animals. Thus pharmaceutical waste are manage by the various treatment processes and also aware to manage the pharmaceutical waste by the drugs

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Vishwanatth, Prof Dr Kannan. "AUTOMATED FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF THE PROTON PUMP INHIBITOR OMEPRAZOLE IN PHARMACEUTICAL FORMULATIONS." International Journal of Engineering Applied Sciences and Technology 7, no. 3 (2022): 63–68. http://dx.doi.org/10.33564/ijeast.2022.v07i03.009.

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A simple and fast flow-injection method for the determination of omeprazole in pharmaceutical preparations is proposed. Detection of the drug is based on the measurement of the absorption signals for the product resulting from the oxidation of omeprazole with N-bromosuccinimide in acidic medium. A flow rate of 0.5 ml/min was pumped and active material was detected at 370 nm. Limit of detection (LOD) and limit of quantitation (LOQ) were calculated to be 2.0 and 6.5 μg/ml, respectively. No interference was observed from common pharmaceutical additives. The method was successfully applied to the

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Onal, Cem, and S. Evrim Kepekçi Tekkeli. "Ultra-fast liquid chromatographic method for the determination of ticagrelor in pharmaceutical formulations and spiked plasma samples." Journal of Chemical Metrology 13, no. 2 (2019): 39–46. http://dx.doi.org/10.25135/jcm.30.19.11.1465.

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Rizk, Mohamed, Safaa S. Toubar, Maha M. A. El-Alamin, and Marwa M. M. Azab. "Micellar liquid chromatographic determination of sertaconazole and terconazole in bulk, pharmaceutical dosage forms and spiked human plasma." Bulletin of Faculty of Pharmacy, Cairo University 52, no. 1 (2014): 155–64. http://dx.doi.org/10.1016/j.bfopcu.2014.03.002.

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13

Boonraeng, S., and N. Punyoyai. "The utilization of agro-industrial waste for soil amendment and liquid biofertilizer mixed bacterial antagonist in eggplant production." IOP Conference Series: Earth and Environmental Science 883, no. 1 (2021): 012087. http://dx.doi.org/10.1088/1755-1315/883/1/012087.

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Abstract This research aimed to improve soil fertility with soil amendment, prepared from agro-industrial waste, and application of antagonistic bacteria for controlling bacterial wilt disease. The experiments were tested on sandy-to-sandy loam soil with low organic matter and nutrients for planting eggplants. Besides the soil improvement with spent mushroom waste and mango peel mixed kernel, the results showed that soil pH, soil organic matter, nitrogen, phosphorus, and potassium increased as available levels. Also, two species of bacterial antagonist named Bacillus subtilis and B. amyloliqui

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14

Baumgarten, S., H. Fr Schröder, C. Charwath, M. Lange, S. Beier, and J. Pinnekamp. "Evaluation of advanced treatment technologies for the elimination of pharmaceutical compounds." Water Science and Technology 56, no. 5 (2007): 1–8. http://dx.doi.org/10.2166/wst.2007.550.

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Pharmaceuticals and their metabolites have developed as ecotoxicologically relevant micropollutants in the aquatic environment. During conventional biological wastewater treatment they are eliminated insufficiently and therefore reach surface waters via discharges. They are either partially or completely non-biodegradable and/or hardly eliminable by activated sludge adsorption because they often have polar structures. Membrane bioreactor treatment (MBR) was applied to pre-treat wastewater containing pharmaceutical compounds, e.g., antibiotics like floxacins and their synthetic precursor compou

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15

Badulla, Wafa F. S., Zeki Atkoşar, Göksel Arli, and Erol Şener. "Application of LC–ESI-MS/MS Method for Analysis of Escitalopram Oxalate in Human Urine and Pharmaceutical Dosage Forms." Journal of Chromatographic Science 58, no. 2 (2019): 91–97. http://dx.doi.org/10.1093/chromsci/bmz073.

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Abstract An effective and sensitive liquid chromatographic–electrospray ionization tandem mass-spectrometric (LC–ESI-MS/MS) method was developed and validated for quantification of escitalopram oxalate (ESC-OX), antidepressant drug in spiked human urine and pharmaceutical formulations. In this work, simple liquid–liquid extraction was optimized and used for extraction of cited drug from urine samples. The chromatographic separation was attained within 6 min including re-equilibration time by using gradient elution with 0.1% formic acid in acetonitrile and 0.1% formic acid in water as mobile ph

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Li, Zhong Jian, Zhe Wei, Wei Xiao, Jun Wang, and Fu An Wu. "Recovery of Tea Polyphenols from Green Tea Waste by Liquid-Liquid Extraction." Advanced Materials Research 396-398 (November 2011): 1592–95. http://dx.doi.org/10.4028/www.scientific.net/amr.396-398.1592.

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Tea (Camellia sinensis L.) has became one of the most consumed beverages in the world in the past five thousand years, and tea polyphenols (TPs) are important organic acids widely used in chemical, pharmaceutical, food and other industries, which have been shown to exhibit various biological and pharmacological properties. In order to look for new technology of downstream process for TPs separation from green tea waste, selective extraction of TPs with 12 varieties of solvents were carried out, the distribution coefficient and equilibrium experiments at various temperatures were described by e

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17

Ferichani, Minar, Darsono Darsono, Sri Marwanti, Wiwit Rahayu, Umi Barokah, and Ernoiz Antriyandarti. "Recycling household waste as a solution to the scarcity of subsidized fertilizer in Jetis Hamlet." Community Empowerment 8, no. 12 (2023): 2011–18. http://dx.doi.org/10.31603/ce.10141.

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Jetis Hamlet, Karanganyar Regency, is currently facing two urgent problems simultaneously: river pollution and fertilizer scarcity. The aim of the RG-EPP community service is to provide education on processing household waste into liquid organic fertilizer (LOF). Methods employed to achieve this goal include socialization, counseling, technical direction, creating video tutorials, training, practicing LOF-making skills, and conducting LOF laboratory tests. The results of this community service activity, besides addressing the issues of river pollution and fertilizer scarcity, indicate that the

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Dembek, Mikołaj, and Szymon Bocian. "Stationary Phases for Green Liquid Chromatography." Materials 15, no. 2 (2022): 419. http://dx.doi.org/10.3390/ma15020419.

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Industrial research, including pharmaceutical research, is increasingly using liquid chromatography techniques. This involves the production of large quantities of hazardous and toxic organic waste. Therefore, it is essential at this point to focus interest on solutions proposed by so-called “green chemistry”. One such solution is the search for new methods or the use of new materials that will reduce waste. One of the most promising ideas is to perform chromatographic separation using pure water, without organic solvents, as a mobile phase. Such an approach requires novel stationary phases or

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19

Zelcbuch, Lior, Elad Yitzhaki, Olga Nissan, et al. "Luminescent Phage-Based Detection of Klebsiella pneumoniae: From Engineering to Diagnostics." Pharmaceuticals 14, no. 4 (2021): 347. http://dx.doi.org/10.3390/ph14040347.

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Bacteriophages (“phages”) infect and multiply within specific bacterial strains, causing lysis of their target. Due to the specific nature of these interactions, phages allow a high-precision approach for therapy which can also be exploited for the detection of phage-sensitive pathogens associated with chronic diseases due to gut microbiome imbalance. As rapid phage-mediated detection assays becoming standard-of-care diagnostic tools, they will advance the more widespread application of phage therapy in a precision approach. Using a conventional method and a new cloning approach to develop lum

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20

Vijaya Sri, K., M. Shiva Kumar, M. A. Madhuri, and Suresha K. "RAPID HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF RALTEGRAVIR IN HUMAN SALIVA." INDIAN DRUGS 56, no. 09 (2019): 68–73. http://dx.doi.org/10.53879/id.56.09.11506.

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In this study, a high-performance liquid chromatographic method (HPLC) was developed, validated and applied for the determination of raltegravir in biological sample like saliva. Liquid- liquid extraction was performed for isolation of the drug and elimination of saliva interferences. Samples of saliva was extracted with 50µL of ortho phosphoric acid and 3ml of methanol was added and spiked with raltegravir. The chromatographic separation was performed on Agilent Eclipse C18 (100 mm × 4.6 mm, 3.5µm) column, by using 80:20 v/v acetonitrile: water as a mobile phase under isocratic conditions at

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Badulla, Wafa F. S., Arın G. Dal Poçan, Zeki Atkoşar, and Göksel Arlı. "Capillary Electrophoresis Method for Determination of Escitalopram Oxalate in Urine Samples and Different Dosage Forms." Journal of Chromatographic Science 58, no. 8 (2020): 759–69. http://dx.doi.org/10.1093/chromsci/bmaa036.

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Abstract Application of capillary electrophoresis (CE) has become a rapidly growing analytical technique for the estimation of drugs in pharmaceutical dosage forms and biological fluids. In this study, an effective and sensitive method was developed for the determination of escitalopram oxalate (ESC-OX) by CE with diode-array detection at 200 nm. The separation was achieved by a fused silica capillary with 40 cm effective length (48.5 cm total, 75 μm i.d.). The background electrolyte was composed of 15 mM phosphate buffer (pH 2.5). The applied potential was 22.5 kV, and the samples were inject

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Yasmin Nabilah, Tanti Nabella Putri, I. Nyoman Widiasa, Adryan Tito, and M. Nur Adyaksa. "Evaluasi Kinerja Instalasi Pengolahan Air Limbah (IPAL) di PT. Rohul Sawit Industri." Jurnal Teknik Kimia USU 11, no. 2 (2022): 95–101. http://dx.doi.org/10.32734/jtk.v11i2.8969.

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This paper reports the performance evaluation results of the wastewater treatment plant and the quality of the effluent from the palm oil mill of PT. Rohul Sawit Industri in 2021, which uses Ponding System methods. PT. Rohul Sawit Industri are allowed to reuse the results of their waste treatment into the Land Application System. The faculative waste is monitored once a month where the data is in accordance with the UKL–UPL matrix. In the liquid waste test, samples of liquid waste are taken from the last outlet which will be flowed to the study area, referring to the applicable water sampling

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Sakhi, Mirina, Abad Khan, Ismail Khan, et al. "A new sensitive HPLC/UV method for simultaneous determination of paclitaxel, sorafenib and omeprazole in standard solutions and spiked plasma: Application to in-vitro and in-vivo evaluation of paclitaxel polymeric nanoformulations." Tropical Journal of Pharmaceutical Research 20, no. 9 (2021): 1949–59. http://dx.doi.org/10.4314/tjpr.v20i9.23.

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Purpose: To develop a simple, novel, sensitive and rapid reverse phase high performance liquid chromatographic method for simultaneous determination of paclitaxel, sorafenib and omeprazole in standard solutions and spiked human plasma and its application to the in-vitro and in-vivo evaluation of paclitaxel polymeric nanoparticle formulations.Methods: The method was tested for the assessment of paclitaxel, omeprazole and sorafenib using tamoxifen citrate as internal standard. The analysis was performed at a wavelength of 235 nm using Thermo HS C18 column, 40 °C column oven temperature, acetonit

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Patel, C. B., C. S. Kothari, N. R. Patel та O. Sherikar. "BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF MEMANTINE HYDROCHLORIDE BY SPECTROFLUORIMETRIC METHOD USING OPA Β-MERCAPTOETHANOL AS DERIVATIZING AGENT". INDIAN DRUGS 51, № 09 (2014): 12–16. http://dx.doi.org/10.53879/id.51.09.10120.

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A new, simple, accurate, sensitive and specific bioanalytical spectrofluorimetric method was developed and validated for estimation of memantine hydrochloride (MEM) in human plasma. Estimation of MEM in human plasma was done by spiked human plasma studies. Extraction of MEM from human plasma was carried out using 5% trichloroacetic acid for protein precipitation followed by liquid-liquid extraction with 5% IPA in n-hexane. For spectrofluorimetric estimation delta value 65 applied in synchronous mode (medium sensitivity mode) and fluorescence intensity was measured at 420 nm. Developed method w

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Nadeem Ul Hassan Khan, Asad Hamad, Quratulain, et al. "Quantitative Determination of Lidocaine Hydrochloride in Pharmaceutical Preparations Using HPLC-UV Detection." Indus Journal of Bioscience Research 3, no. 1 (2025): 287–94. https://doi.org/10.70749/ijbr.v3i1.494.

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Objective: To develop and validate a robust and sensitive High-Performance Liquid Chromatography (HPLC) method with ultraviolet (UV) detection for the quantification of Lidocaine-HCl in pharmaceutical formulations. Methods: An Ion Pac Ercus C18 reversed-phase column (250 mm × 4.5 mm, 5 µm) was used at 25°C with a mobile phase of water and acetonitrile (80:20, v/v) containing 5% acetic acid (pH 3.4). The flow rate was maintained at 1.0 mL/min, and detection was performed at 254 nm. Calibration standards (0.1–0.5 µg/mL) were prepared, and validation parameters including linearity, sensitivity, p

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Santonocito, Debora, Giuseppe Granata, Corrada Geraci, et al. "Carob Seeds: Food Waste or Source of Bioactive Compounds?" Pharmaceutics 12, no. 11 (2020): 1090. http://dx.doi.org/10.3390/pharmaceutics12111090.

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(1) Background: For centuries, carob fruit has been used in the food field, while carob seeds have been mainly considered as food waste. Nowadays, there has been considerable attention toward the recovery of the waste plant matrices as possible sources of functional compounds with health properties. Therefore, our goal was to evaluate the health properties of carob seed extracts, and to study the effects of the ripening process on the chemical composition of the extracts. (2) Methods: After the mechanical separation of seeds from carob fruit, an ultrasound-assisted extraction (UAE) was perform

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El-Deen, Asmaa Kamal, Heba Elmansi, and Kuniyoshi Shimizu. "Utilization of hydrophilic and hydrophobic deep eutectic solvents for dispersive liquid-liquid microextraction of bicalutamide from water and spiked human plasma." Sustainable Chemistry and Pharmacy 29 (October 2022): 100825. http://dx.doi.org/10.1016/j.scp.2022.100825.

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Gamal, Mohammed, and Lobna Mohammed Abd Elhalim. "Novel Eco-friendly HPLC Methods Using Refractive Index Detector for Analysis of Three Veterinary Antibiotics in Pharmaceutical Formulations and Rat Plasma." Journal of Chromatographic Science 58, no. 10 (2020): 940–50. http://dx.doi.org/10.1093/chromsci/bmaa065.

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Abstract Antibiotic resistance increases the human mortality rate nowadays. The main purpose of the present study was to develop green reversed-phase high-performance liquid chromatography (RP-HPLC) methods with a refractive index detector for the assay of the three veterinary antibiotics (VAs), i.e., maduramicin ammonium (MA), apramycin sulfate (AS) and clarithromycin (CLA) in pharmaceutical dosage forms and spiked rat plasma. The method utilized isocratic elution using an ODP-40 C18 column, the flow rate was set at 1.0 mL/min and negative polar signals. The linearity ranges were 3.0–18.0 μg/

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Sagiroglu, Ali Asram, Cem Onal, and S. Evrim Kepekçi Tekkeli. "Liquid chromatographic analysis for the determination of deferasirox in pharmaceutical formulations and spiked plasma samples using dansyl chloride reagent." Journal of Chemical Metrology 14, no. 1 (2020): 35–41. http://dx.doi.org/10.25135/jcm.35.20.01.1518.

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Fahmy, Ossama T., Mohamed A. Korany, and Hadir M. Maher. "High performance liquid chromatographic determination of some co-administered anticancer drugs in pharmaceutical preparations and in spiked human plasma." Journal of Pharmaceutical and Biomedical Analysis 34, no. 5 (2004): 1099–107. http://dx.doi.org/10.1016/s0731-7085(03)00655-1.

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Khatri, Sweety. "BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF LEVOCETIRIZINE IN BLOOD PLASMA BY USING RP-HPLC." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 288–92. http://dx.doi.org/10.22270/jddt.v8i5-s.1977.

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A rapid, selective, precise and sensitive reverse phase high-performance liquid chromatography method was developed for the quantitative estimation of Levocetirizine Dihydrochloride (LD) in human plasma and pharmaceutical dosage form. Extraction of drug from plasma was done by employing optimized liquid-liquid extraction procedure. The sample was analyzed using acetonitrile: methanol: 20mM ammonium acetate buffer pH-5 (25:55:20 % v/v/v) as mobile phase. Chromatographic separation was achieved on Thermo C-18 column (4.6 x 250mm, 5μ particle size) as stationary phase using isocratic elution (at

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A.K, Singh, Kharb R, and Kandpal J.B. "Organic Extraction, Purification and Evaluation of Long Chain Fatty Alcohol from Saccharum officinarum of Sugar Refinery Waste for Human Wellness." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 860–63. http://dx.doi.org/10.25258/ijddt.13.3.14.

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The current study has explored an extraction and purification method for 1-octacosanol from sugarcane waste, commonly known as press mud, through the application of SCFE by the unique concept of solid-solid and liquid-liquid extraction which increases content and decreases impurity which is an extra advantage at purification stage by help of green solvent instead any carcinogenic solvent, which reduce process time, increase content and environment friendly. The isolated compounds were characterized by gas chromatography-flame ionization detection, which shows 50% content of octacosanol in the

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B., K. Kempegowda. "ANALYSIS OF DRUG IN PHARMACEUTICAL WASTE WATER BY MULTIPLE EFFECT EVAPORATORS." Shanlax International Journal of Arts, Science and Humanities 6, S2 (2019): 141–49. https://doi.org/10.5281/zenodo.2580755.

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<em>Disposal of effluent from pharmaceutical industry is an increasing problem in India and worldwide. The bulk drug manufacturing process involves usage of more organic and inorganic salts, which is becoming major part of high chemical oxygen demand and total dissolved solids. Evaporation and cooling are the common techniques used to extract available salts and reusable water. The pharmaceutical industry of the study uses multiple effect falling and forced circulation evaporator to achieve zero liquid discharge process for pharmaceutical effluent. Multiple Effect Evaporator is a thermal evapo

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B.K., Kempegowda. "ANALYSIS OF DRUG IN PHARMACEUTICAL WASTE WATER BY MULTIPLE EFFECT EVAPORATOR." Shanlax International Journal of Arts, Science and Humanities 6, S2 (2019): 228–36. https://doi.org/10.5281/zenodo.2635077.

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<em>Disposal of effluent from pharmaceutical industry is an increasing problem in India and worldwide. The bulk drug manufacturing process involves usage of more organic and inorganic salts, which is becoming major part of high chemical oxygen demand and total dissolved solids. Evaporation and cooling are the common techniques used to extract available salts and reusable water. The pharmaceutical industry of the study uses multiple effect falling and forced circulation evaporator to achieve zero liquid discharge process for pharmaceutical effluent.  Multiple Effect Evaporator is a thermal

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Wang, Yixiao, Jinhua Li, Ling Ji, and Lingxin Chen. "Simultaneous Determination of Sulfonamides Antibiotics in Environmental Water and Seafood Samples Using Ultrasonic-Assisted Dispersive Liquid-Liquid Microextraction Coupled with High Performance Liquid Chromatography." Molecules 27, no. 7 (2022): 2160. http://dx.doi.org/10.3390/molecules27072160.

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The residues and abuse of antibiotics have seriously endangered ecological balance and human health; meanwhile, antibiotics determination is very difficult because of their low levels and multiple categories in complicated matrices. Appropriate sample pretreatment is usually imperative to enrich (ultra)trace antibiotics and eliminate matrix interference prior to chromatographic analysis. Dispersive liquid-liquid microextraction (DLLME) has become an ideal pretreatment technique owing to its simplicity, effectiveness, low-consumption, etc. In this work, an ultrasonic-assisted DLLME (UA-DLLME) w

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Abdel-Gawad, Sherif A., and Mubarak A. Alamri. "Selective simultaneous ultra-performance liquid chromatographic quantification of some benzodiazepines drug residues in pharmaceutical industrial wastewater." Tropical Journal of Pharmaceutical Research 21, no. 9 (2022): 1951–57. http://dx.doi.org/10.4314/tjpr.v21i9.19.

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Purpose: To investigate the sensitivity and selectivity of ultra-performance liquid chromatographic (UPLC) quantification of bromazepam (BRZ) and diazepam (DZP) in pharmaceutical industrial wastewater. Methods: Wastewater samples were collected from the effluents of a pharmaceutical industrial plant producing BRZ and DZP in tablet dosage forms. The quantification of BRZ and DZP was done after their solid-phase extraction. The resolution process was performed on WatersTM column as the stationary phase. The mobile phase was acetonitrile: methanol: 0.05 M phosphate buffer (pH 6.5), at a vol

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Abou El-Alamin, Maha M., Maha A. Sultan, Mostafa A. Atia, and Hassan Y. Aboul-Enein. "Novel Application of Pentabromobenzyl Column for Simultaneous Determination of Eight Antifungal Drugs Using High-performance Liquid Chromatography." Combinatorial Chemistry & High Throughput Screening 23, no. 10 (2020): 991–1001. http://dx.doi.org/10.2174/1386207323666200220114818.

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Aim: A new, accurate and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) as an analytical method for the quantitative determination of eight antifungal drugs in spiked human plasma has been described optimized and validated. Methods and Materials: The analyzed compounds were voriconazole (VOR), luliconazole (LUL), clotrimazole (CLO), tioconazole (TIO), posaconazole (POS), ketoconazole (KET), sertaconazole (SER) and terconazole (TER). Results: The separation of the analyzed compounds was conducted using a novel pentabromobenzyl column known as COSMOSIL PBB-R (150 mm ×

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Timmons, Jo Anne, John C. Meyer, Daniel J. Steible, and Sebastian P. Assenza. "Reverse Phase Liquid Chromatographic Assay for Calcium Pantothenate in Multivitamin Preparations and Raw Materials." Journal of AOAC INTERNATIONAL 70, no. 3 (1987): 510–13. http://dx.doi.org/10.1093/jaoac/70.3.510.

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Abstract A reverse phase liquid chromatographic (LC) method has been developed for the assay of calcium pantothenate in commercial multivitamin tablet formulations and raw materials. The assay was validated according to the Pharmaceutical Manufacturers Association Quality Control HPLC Committee guidelines. The chromatographic system includes a C-18 column and a mobile phase consisting of 0.25M sodium phosphate buffer, pH 2.5, and acetonitrile (97 + 3 v/v). The column effluent is monitored by UV detection at 205 nm. The sample preparation involves only extraction in water followed by filtration

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Güzel, Remziye, Zehra Ceren Ertekin, and Erdal Dinç. "A New Application of PARAFAC Model to UPLC Dataset for the Quantitative Resolution of a Tri-Component Drug Mixture." Journal of Chromatographic Science 59, no. 4 (2021): 361–70. http://dx.doi.org/10.1093/chromsci/bmaa119.

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Abstract In the presented work, a three-way analysis of ultra-performance liquid chromatography-photodiode array (UPLC-PDA) dataset was performed by parallel factor analysis (PARAFAC) for quantitatively resolving a ternary mixture containing paracetamol and methocarbamol with indapamide selected as an internal standard in their co-eluted chromatographic conditions. Paracetamol and methocarbamol were quantified in the working range between 3–24 and 5–50 μg/mL by applying PARAFAC decomposition to UPLC-PDA data array obtained under unresolved chromatographic peak conditions. To compare the experi

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Diab, Hanin, Alexandra Calle, and Jonathan Thompson. "Rapid and Online Microvolume Flow-Through Dialysis Probe for Sample Preparation in Veterinary Drug Residue Analysis." Sensors 24, no. 12 (2024): 3971. http://dx.doi.org/10.3390/s24123971.

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A rapid and online microvolume flow-through dialysis probe designed for sample preparation in the analysis of veterinary drug residues is introduced. This study addresses the need for efficient and green sample preparation methods that reduce chemical waste and reagent use. The dialysis probe integrates with liquid chromatography and mass spectrometry (LC-MS) systems, facilitating automated, high-throughput analysis. The dialysis method utilizes minimal reagent volumes per sample, significantly reducing the generation of solvent waste compared to traditional sample preparation techniques. Seve

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Rajendraprasad, Nagaraju, KanakapuraB Vinay, HosakereD Revanasiddappa, PavagadaJ Ramesh, and Kanakapura Basavaiah. "Reversed phase high performance liquid chromatographic method for determination of quetiapine fumarate in pharmaceutical formulation and in spiked human urine." Journal of Reports in Pharmaceutical Sciences 2, no. 2 (2013): 131. http://dx.doi.org/10.4103/2322-1232.222530.

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Noh, Keumhan, Hyun-Moon Back, Beom Soo Shin, and Wonku Kang. "Pharmacokinetics of Shikimic Acid Following Intragastric and Intravenous Administrations in Rats." Pharmaceutics 12, no. 9 (2020): 824. http://dx.doi.org/10.3390/pharmaceutics12090824.

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Shikimic acid, a critical starting material for the semi-total synthesis of oseltamivir to treat and prevent influenza, exerts many pharmacological effects. However, the optimal bioanalytical method has not been adequately defined. We used liquid chromatography-tandem mass spectrometry to quantitate shikimic acid in rat plasma and studied its pharmacokinetics after intragastric and intravenous administration. Plasma was spiked with an internal standard, and the proteins were precipitated with acetonitrile, followed by solvent evaporation and reconstitution of the mobile phase. Shikimic acid wa

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Köhler, Niklas, Hande Karaköse, Hans-Peter Grobbel, et al. "A Single-Run HPLC–MS Multiplex Assay for Therapeutic Drug Monitoring of Relevant First- and Second-Line Antibiotics in the Treatment of Drug-Resistant Tuberculosis." Pharmaceutics 15, no. 11 (2023): 2543. http://dx.doi.org/10.3390/pharmaceutics15112543.

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The treatment of drug-resistant Mycobacterium tuberculosis relies on complex antibiotic therapy. Inadequate antibiotic exposure can lead to treatment failure, acquired drug resistance, and an increased risk of adverse events. Therapeutic drug monitoring (TDM) can be used to optimize the antibiotic exposure. Therefore, we aimed to develop a single-run multiplex assay using high-performance liquid chromatography–mass spectrometry (HPLC–MS) for TDM of patients with multidrug-resistant, pre-extensively drug-resistant and extensively drug-resistant tuberculosis. A target profile for sufficient perf

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Muhamad Yusri, Nurin Farawani Binti, Noorashikin Binti Md Saleh, Tanusha Devi Elan Solan, and Muhammad Zulhaziman Mat Salleh. "A Vortex-Assisted Deep Eutectic Solvent for Parabens Extraction in Cosmetic Samples Coupled with High Performance Liquid Chromatography." Sains Malaysiana 53, no. 4 (2024): 851–68. http://dx.doi.org/10.17576/jsm-2024-5304-10.

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Parabens, commonly used preservatives in food, cosmetics, and pharmaceutical items, inhibit harmful germ growth. Deep Eutectic Solvents (DES) are intriguing for analyte extraction due to superior properties formed through hydrogen bond acceptors and donor interactions. However, the studies on the optimal DES-based extraction conditions for paraben-containing cosmetics and the accuracy of 'paraben-free' labels are limited. The most effective DES (DL-Menthol and decanoic acid, 1:2 molar ratio) was applied to cosmetic samples after heating at 80 °C following optimization parameters. FTIR study co

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Avila, Viorica Lopez, Sarah Schoen, June Milanes, and Werner F. Beckert. "Single-Laboratory Evaluation of EPA Method 8080 for Determination of Chlorinated Pesticides and Polychlorinated Biphenyls in Hazardous Wastes." Journal of AOAC INTERNATIONAL 71, no. 2 (1988): 375–87. http://dx.doi.org/10.1093/jaoac/71.2.375.

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Abstract Method 8080, as published in the Second Edition of "Test Methods for Evaluating Solid Waste," EPA Manual SW-846, has been evaluated in a single-laboratory study. The Florisil procedure recommended in Method 8080 for sample cleanup does not separate organochlorine pesticides (OCPs) from the polychlorinated biphenyls (PCBs). Consequently, gas chromatographic analysis of OCPs on the packed column recommended in the method may result in false identifications or in no identifications at all when PCBs are present. Therefore, silica gel was substituted for Florisil, a capillary column was su

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Phiri, Masauso Moses, Elmarie Davoren, and Barend Christiaan Vorster. "Miniaturization and Automation Protocol of a Urinary Organic Acid Liquid-Liquid Extraction Method on GC-MS." Molecules 28, no. 15 (2023): 5927. http://dx.doi.org/10.3390/molecules28155927.

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The aim of this study was to improve the extraction method for urinary organic acids by miniaturizing and automating the process. Currently, manual extraction methods are commonly used, which can be time-consuming and lead to variations in test results. To address these issues, we reassessed and miniaturized the in-house extraction method, reducing the number of steps and the sample-to-solvent volumes required. The evaluated miniaturized method was translated into an automated extraction procedure on a MicroLab (ML) Star (Hamilton Technologies) liquid handler. This was then validated using sam

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Khan, Amna, Nazish Jaffar, Sadaf Razzak, Faizan Zeesahn, Asma Shabbir, and Syed Muhammad Ishaque. "Knowledge, Attitude and Practices of Pharmaceutical Waste Disposal in Community Pharmacies of Karachi." ANNALS of JINNAH SINDH MEDICAL UNIVERSITY 6, no. 2 (2020): 54–59. http://dx.doi.org/10.46663/ajsmu.v6i2.54-59.

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Objectives: The aim of the study was to assess the knowledge of community pharmacies about recommended methods of drug disposal and hazardous effects of improper disposal of pharmaceutical waste and to determine the attitude as well as practice of community pharmacies about the proper disposal of pharmaceutical waste. Methods: A cross-sectional study was performed with 139 community pharmacies in Karachi, Pakistan by using non-probability convenient sampling technique. Predesigned structured questionnaire was distributed to different community pharmacies in Karachi and filled questionnaires we

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Dewi, I'anatul Ulya, R. Azizah, Zida Husnina, et al. "Effectiveness of Wastewater Treatment Installation and Liquid Waste Quality in Dr. Soetomo General Hospital, Surabaya." JURNAL KESEHATAN LINGKUNGAN 14, no. 1 (2022): 45. http://dx.doi.org/10.20473/jkl.v14i1.2022.45-54.

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Introduction: Hospitals are institutions that produce liquid waste that may pollute the environment and have a dangerous impact on health. Hospital waste has the potential to contain hazardous chemicals, pharmaceutical waste, radioactivity and microbiological pathogens in liquid waste that can pollute the environment and disrupt the balance of the ecosystem. This study aims to determine the effectiveness of the Wastewater Treatment Plant (WWTP) and the quality of the liquid waste at the Dr. Soetomo General Hospital. Methods: This research was a quantitative descriptive study using secondary da

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Elhassan Elkhalifa, Issam Osman, and M. I. Shukri. "TREATMENT AND MANAGEMENT OF BIOHAZARDOUS LIQUID WASTE IN CLINICAL LABORATORIES IN SUDAN – KHARTOUM STATE." International Journal of Engineering Applied Sciences and Technology 09, no. 12 (2025): 01–14. https://doi.org/10.33564/ijeast.2025.v09i12.001.

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This study emphasizes the importance of effective biohazardous liquid waste management in clinical laboratories to protect public health and the environment, particularly in low-income settings like Sudan. Improper disposal practices in Sudan lead to significant risks, including groundwater contamination and disease outbreaks. The research explores the potential of Programmable Logic Controllers (PLC) and Supervisory Control and Data Acquisition (SCADA) systems to automate waste treatment processes, enhancing precision and minimizing human exposure to hazardous materials. Biohazardous liquid w

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Aktor, Henrik. "Continuous high-rate removal of chromate in a fluidised bed without sludge generation." Water Science and Technology 30, no. 7 (1994): 31–40. http://dx.doi.org/10.2166/wst.1994.0298.

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The objective of the work presented here was to investigate the catalysing effect of iron oxyhydroxide on the redox reaction between ferrous iron and chromate. This was done in a bench-scale upflow reactor containing an expanded sand medium (fluid-bed reactor), where continous chemical addition, reaction and solid-liquid separation take place. Removal efficiencies of chromate in excess of 99% were attainable on spiked tapwater corresponding to an outlet concentration of 0.01 mg/l. Chromate polluted groundwater from a fly-ash disposal site was treated in the first full-scale plant (3 m3/h) with

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