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Dissertations / Theses on the topic 'Spinal cord computational model'

Author: Grafiati

Published: 10 March 2023

Last updated: 31 July 2025

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1

Parziale, Antonio. "A neurocomputational model of reaching movements." Doctoral thesis, Universita degli studi di Salerno, 2016. http://hdl.handle.net/10556/2341.

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2013 - 2014<br>How the brain controls movement is a question that has fascinated researchers from different areas as neuroscience, robotics and psychology. To understand how we move is not only an intellectual challenge, but it is important for finding new strategies for nursing people with movement diseases, for rehabilitation and to develop new robotic technology. While there is an agreement about the role of the primary motor cortex (M1) in the execution of voluntary movements, it is still debated what (and how) is encoded by the neural activity of the motor cortex. To unveil the "c

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2

Altas, Melanie. "Spinal cord transplants in a rat model of spinal cord injury." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0021/MQ49305.pdf.

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3

Bhatnagar, Timothy. "Quantification of morphological changes of the cervical spinal cord during traumatic spinal cord injury in a rodent model." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52175.

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Traumatic spinal cord injury initiates a complex pathophysiological process that eventually manifests as persistent tissue damage and possible permanent loss of neurologic function. Current experimental models are limited to measuring the gross mechanical response of the spinal cord during injury; thus, little is known about how the internal tissues of the spinal cord deform during injury. The general aims of this research were to develop a method to observe the internal deformations of the in vivo rat spinal cord during clinically-relevant injury models and to determine if the patterns of def

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4

Fukuda, Seijun. "New canine spinal cord injury model free from laminectomy." Kyoto University, 2006. http://hdl.handle.net/2433/135626.

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5

Lucas, Erin. "Measuring in vivo internal spinal cord deformations during experimental spinal cord injury using a rat model, radiography, and fiducial markers." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/27808.

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Spinal cord injuries (SCIs) are commonly studied experimentally by causing injury to rodent spinal cords in vivo and analyzing behavioral and histological results post injury. Few researchers have directly investigated the deformation of the in vivo spinal cord during impact, which is thought to be a predictor of injury. This knowledge would help to establish correlations among impact parameters, internal structure deformation, and histological and functional outcomes. The objective of this thesis was to develop a radiographic method of tracking the real-time internal deformations of an anesth

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6

Prince, Karen. "The computational modelling of the spinal cord neurons involved in the pain process." Thesis, University of Northampton, 2006. http://nectar.northampton.ac.uk/2696/.

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Pain is a personal subjective experience with physiological and psychological components and involves many complex processes. In 1965 Melzack and Wall proposed the influential gate control theory (GCT) of pain and, in general, this has been supported by subsequent research. This theory postulates that cells in the substantia gelatinosa, located within the spinal cord, act like a gate mechanism that modulates the flow of information through the spinal cord to the brain and thus impacts on the pain experience. The abundance of literature and experimental data that is available from pain research

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7

Sowd, Matthew Michael. "Analyzing Non-Unique Parameters in a Cat Spinal Cord Motoneuron Model." Thesis, Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/11545.

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When modeling a neuron, modelers often focus on the values of parameters that produce a desired output. However, if these parameters are not unique, there could be a number of parameter sets that produce the same output. Thus, even though the values of the various maximum conductances, half activation voltages and so on differ, as a set they can produce the same spike height, firing rates, and so forth. To examine whether or not parameter sets are unique, a 3-compartment motoneuron model was created that has 15 target outputs and 59 parameters. Using parameter searches, over one hundred

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8

Rogers, A. T. "Spinal cord cell culture : a model for neuronal development and disease." Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234048.

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9

Chen, Hsiao-Yu. "Developing a model of spinal cord injury rehabilitation nursing using grounded theory." Thesis, University of Ulster, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413285.

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10

Corkill, Dominic John. "Endothelin-1 induced focal ischaemia : a novel model of spinal cord injury." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397757.

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11

Goode, Stephen Thomas. "Development of a spinal cord injury model using the material point method." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/17561/.

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Spinal cord injury (SCI) is characterised by permanent loss of motor and sensory function. The primary damage from the initial mechanical insult is exacerbated by the secondary patho-physiological cascade. Research into neuroprotective interventions to preserve tissue and reduce the damage caused by the secondary injury is hampered, in part, due to a lack of understanding of the link between the biomechanics of the primary traumatic injury and the subsequent evolution of the secondary injury. Hence, there is a need to better understand the biomechanics of SCI, the distinct injury patterns prod

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12

Mattucci, Stephen Frank Ernesto. "A biomechanical investigation of a dislocation spinal cord injury in a rat model." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/64175.

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Traumatic spinal cord injuries clinically occur in a heterogeneous fashion, including at different spinal levels, injury velocities, and injury mechanisms. Clinical treatment options, such as early surgical decompression produce inconsistent recovery outcomes in the patient population, despite demonstrating effectiveness in preclinical animal models. The most common biomechanical factors, such as cervical level, high-energy impact and dislocation injury mechanism, are not adequately represented in preclinical models, which may explain the lack of agreement between clinical studies. The overall

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13

Ross, Lewis. "The development of an in vitro model of spinal cord injury using microfabrication." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4365/.

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This project aimed to develop an in vitro model of spinal cord injury. A device was developed that could, in conjunction with an existing myelinating culture system, aligned axons into parallel rows and contain the soma to a predefined area; thus creating a structure similar to the spinal cord. It was intended for the device to be simple to produce and use, provide easy accesses to the axons for wounding and allow simple measurement of axonal regrowth. An additional aim of the project was to develop a method of cell wounding that was reproducible, precise and allowed observation of the woundin

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14

Jones, Page. "Enzymatic and proteomic analysis of spinal cord in a G93A ALS mouse model." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008r/jonesp.pdf.

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15

Otoshi, Chad Kuniyuki. "Receptor plasticity in the lumbar spinal cord a move to a simpler model /." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1679374141&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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16

Merta, Nika Janet. "A spinal cord model for studying diffusion and enhanced mixing of a dye." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0025071.

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17

Ebrahimi, Nasrabady Sara. "A study of excitotoxicity as pathological process responsible for spinal cord injury: insight from an in vitro rat spinal cord model with a focus on neuroprotection." Doctoral thesis, SISSA, 2012. http://hdl.handle.net/20.500.11767/4692.

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Excitotoxicity is considered to be a major contributor to pathophysiological mechanisms responsible for spinal cord damage after acute injury. Hyperactivation of poly(ADP-ribose) polymerase (PARP) is the chief effector of neuronal death which leads to cell energy depletion and DNA damage with the manifestation of non-apoptotic cell death termed parthanatos. Glutamate mediated excitotoxicity is also one important component of post-traumatic degeneration following spinal cord injury (SCI). Kainate (1 h), a potent non-degradable analog of glutamate, was used to induce excitotoxic injury in our in

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18

Gensel, John Carib. "Modeling and treatment of rat cervical spinal cord injury." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1167753874.

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19

Marchionne, Francesca. "INTRATHECAL DELIVERY OF BDNF TO THE LUMBAR SPINAL CORD VIA IMPLANTED MINI-PUMP RESTORES STEPPING AND MODULATES THE ACTIVITY OF THE LUMBAR SPINAL INTERNEURONS IN A LARGE ANIMAL MODEL OF SPINAL CORD INJURY." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/480625.

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Bioengineering<br>Ph.D.<br>Delivery of neurotrophins to the injury site via cellular transplants or viral vectors administration has previously been shown to promote recovery of locomotor behavior in the absence of locomotor training in adult spinalized animals. Viral vectors still pose clinical concerns associated to recombinant genetics and the lack of understanding of how they react with the human immune system. Delivery via graft of autologous fibroblast engineered to produce brain derived neurotrophic factor (BDNF) and Neurotrophin-3 (NT-3) has been shown as a valuable method; however, th

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20

Almarestani, Lina. "Changes in the spinal cord and peripheral innervation in an animal model of arthritis." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32288.

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Neurons in the marginal layer (lamina I) of the dorsal horn of the spinal cord play a major role in the transmission and integration of pain-related sensory information that is relayed to the brain. Alteration in excitability of these cells greatly influences pain perception. Among these, alterations of the substance P (SP) system play a major role because of its known involvement in spinal cord nociceptive mechanisms. In this thesis, our main focus was on the characterization of the cell populations in l

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21

Szebeni, Katalin, Attila Szebeni, T. DiPeri, N. Davis, Gregory A. Ordway, and J. L. Ardell. "Thoracic Spinal Cord Stimulation Protects the Hippocampus in a Canine Model of Heart Failure." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/8635.

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22

Shabbir, Ayisha. "Study of the neuroprotection mechanisms in a model of spinal cord injury in vitro." Doctoral thesis, SISSA, 2015. http://hdl.handle.net/20.500.11767/3891.

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Excitotoxicity is the major contributor to the pathophysiological damage after acute spinal cord injury which is often incomplete, yet it produces paralysis with uncertain outcome for gait recovery despite early intensive care support. Neuroprotecting the spinal cord during the early phase of injury is an important goal to determine a favourable outcome to suppress delayed pathological events that extend the primary damage and amplify the loss of motor function often with irreversible consequences. While intensive care and neurosurgical intervention remain mainstay treatments, effective neurop

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23

Scali, Manuela. "Fluoxetine treatment promotes functional recovery in a rat model of cervical spinal cord injury." Doctoral thesis, Scuola Normale Superiore, 2014. http://hdl.handle.net/11384/85978.

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24

Cocchi, M. A. "THE MELATONIN PROTECTIVE ROLE IN AN ORGANOTYPIC MODEL OF SPINAL CORD INJURY SECONDARY DAMAGE." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/351674.

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Spinal cord injury (SCI) is characterized to be a two-step process composed by the primary lesion consisting of the initial trauma and the secondary damage, characterized by multiple processes including inflammation, oxidative stress and cell death that lead to a significant expansion of the original damage and to an increase of the functional deficit. Among the aforementioned processes, the oxidative stress plays a significant role in pathophysiology of SCI. In this study, we evaluated the role of melatonin, potent antioxidant and immunomodulator indoleamin, on the oxidative stress, the tissu

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25

Chen, Henry Szu-Meng. "Validation and optimization of myelin water imaging in a preclinical model of spinal cord injury." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59685.

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Myelin content is an important marker for neuropathology; however, direct imaging of myelin is difficult. Consequently, quantitative T2 based myelin water imaging measures myelin content indirectly by probing the property of the surrounding water. Typically, a lengthy multi-echo spin-echo sequence is used to obtain decay curves that are fitted to produce T2 distributions. In white matter, two peaks are observed, one with short and one with long T2 associated with water trapped between the myelin lipid bilayers and intra/extracellular water. The ratio of myelin water peak to the entire distribu

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26

Joshi, Mital. "Development and characterization of a graded, in vivo, compressive, murine model of spinal cord injury." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/MQ54138.pdf.

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27

Uzel, Sébastien G. M. "Microfluidic and optogenetic technologies to model spinal cord development and neuromuscular junction formation and function." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/103850.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2015.<br>"June 2015." Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 106-118).<br>Motor neurons located in the spinal cord and innervating muscle cells throughout the body are responsible for virtually all motor functions, from locomotion to respiration or speech. They arise from differentiation of progenitor cells within the neural tube under spatiotemporally well-defined morphogen concentration profiles, and extend axons into the peripheral nervous system followin

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28

Smith, Jenny Thompson. "A 3D culture model to investigate cellular responses to mechanical loading in spinal cord injury." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16199/.

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Spinal cord injury (SCI) can cause paralysis, loss of sensation, and respiratory dependency, which has a significant impact on the quality of life of patients, their life expectancy and is also a significant economic burden due to the high costs associated with primary care and loss of income. One of the difficulties in establishing a treatment method is the heterogeneity of SCI; there are many different types and severities of traumatic primary injury, across different age groups of patients and different locations within the spinal cord, whilst at a cellular level, there are multiple, intera

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29

Lefeuvre, Jennifer. "Characterization of spinal cord lesions in the marmoset EAE model using MRI and histopathology techniques." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS208.

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Jusqu’à 90% des patients atteints de sclérose en plaque (SEP) présentent des lésions dans la moëlle épinière. L’imagerie par résonance magnétique (IRM) des lésions médullaires demeure un challenge difficile et par conséquent, leur développement et le lien avec la progression clinique du patient restent à ce jour fortement méconnus. Encéphalomyélite auto-immune expérimentale (EAE) chez le marmoset présente des caractéristiques lésionnelles cérébrales ainsi que des déficits sensori-moteurs se rapprochant fortement de la SEP. L’objectif de cette thèse a été de développer de nouveaux protocoles IR

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30

Hutchinson, Jessika Marie. "Elimination of microglia from the spinal cord: A model to examine plasticity following peripheral axon injury." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1533205031089256.

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31

Bianchetti, Elena. "Cell death neuroprotection and repair mechanisms in a model of rat spinal cord injury in vitro." Doctoral thesis, SISSA, 2013. http://hdl.handle.net/20.500.11767/4099.

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Nowadays, new spinal cord injury (SCI) cases are frequently due to non traumatic causes, especially vascular disorders. A prerequisite to developing mechanism-based neuroprotective strategies for acute SCI is a full understanding of the early pathophysiological changes to prevent later disability and paralysis. The immediate damage spreads from the initial site through excitotoxicity and metabolic dysfunction (ischemia, free radicals and neuroinflammation) to surrounding tissue (secondary damage). Using an in vitro neonatal rat spinal cord model, an experimental protocol (pathological medium,

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32

Lui, R. "IN VIVO IMAGING OF STEM CELL MEDIATED TREATMENT IN A MOUSE MODEL OF SPINAL CORD INJURY." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150208.

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Introduction: The use of adult stem cells in cell-mediated therapies is an area of considerable interest within tissue regeneration research. However, important variables such as the distribution of the injected cells, cell survival, target organ localisation cell proliferation and differentiation cannot be evaluated in vivo by using classical imaging approaches. This study propose multiple labelling protocols for in vivo visualisation by MRI, nuclear imaging and BLI of adult murine neural stem cell-mediated therapy, in spinal cord injury animal models. Methods: Murine neural stem cells (mNSCs

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33

Richard, Levine, Richard Vaillancourt, and Ralph Fregosi. "Evaluation of the Brainstem Spinal Cord Preparation in the Neonatal Rat as a Model for Prenatal Nicotine Exposure." The University of Arizona, 2012. http://hdl.handle.net/10150/614504.

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Class of 2012 Abstract<br>Specific Aims: The goal of this project was to evaluate the use of a preparation of the brainstem and spinal cord of neonatal rats that has been widely used for observing and quantifying central nervous activity, as well as the response to pharmacological manipulation. To achieve this, we specifically aimed to remove the intact brainstem and spinal cord of newborn rats, and develop a preparation that would maintain physiological function and allow for recording of electrical activity. Methods: Multiple dissections were performed on neonatal rats. Conditions during

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34

Ankeny, Daniel P. "The effects of brain-derived neurotrophic factor and intraspinal marrow stromal cell transplantation in a rat model of experimental spinal cord injury." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1040224622.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xxiii, 186 p.; also contains graphic material (some col.). Includes abstract and vita. Advisor: Bradford T. Stokes, Dept. of Physiology and Cell Biology. Includes bibliographical references (p. 157-186).

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35

LeMoine, Dana. "Efficacy and Impacts of Perioperative Bupivacaine and Buprenorphine in a Rat Model of Thoracic Spinal Cord Injury." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu152421729752612.

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36

Heiden, Erin Ose. "Injuries among individuals with pre-existing spinal cord injury: understanding injury patterns, burdens, and prevention." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1624.

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As a growing body of research has focused on the individual, social, and environmental factors that facilitate life after spinal cord injury (SCI), particular emphasis has been placed on health conditions that are modifiable and preventable. Subsequent injuries are a serious health problem for individuals with SCI. They are a direct threat to further morbidity and mortality, and are both a cause and consequence other secondary health conditions. As a first step toward understanding this public health problem, the purpose of this dissertation research was to describe the patterns, burdens, and

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37

Aubé, Benoit. "Dynamics of myeloid cell infiltration and blood-spinal cord barrier disruption in a murine model of multiple sclerosis." Thesis, Université Laval, 2013. http://www.theses.ulaval.ca/2013/30428/30428.pdf.

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La rupture de la barrière hémoencéphalique (BHE) ainsi que l’infiltration cellulaire sont des évènements pathophysiologiques caractéristiques de la sclérose en plaques et de son modèle animal, l’encéphalomyélite autoimmune expérimentale (EAE). Cependant, leur relation avec l’évolution de l’EAE est obscure, notamment car les préparations histologiques standards recquièrent le sacrifice des animaux et nous privent d’informations cruciales quant à l’initiation, au développement et à la progression de la maladie. Nous utilisons le modèle EAE chez la lignée de souris lys-GFP ki, chez laquelle les c

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38

Olby, Natasha J. "An experimental model of rat spinal cord injury : its development and studies on manipulation of its glial environment." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243014.

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39

Fox, Jonathan Howard. "Spinal cord gene expression changes in the chicken (Gallus gallus) model of phenyl saligenin phosphate induced delayed neurotoxicity." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/27192.

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Some organophosphorus (OP) esters induce a central-peripheral distal axonopathy called organophosphorus ester-induced delayed neurotoxicity (OPIDN). In the chicken model neurological deficits and microscopic lesions develop 7-21 days after exposure. Neurotoxic esterase (NTE) is thought to be the initial target in OPIDN. Evidence indicates that neuropathic OP esters have to bind NTE and chemically ?age? for OPIDN induction. It was hypothesized that phenyl saligenin phosphate (PSP), a neuropathic OP ester that essentially irreversibly inhibits NTE as it undergoes the chemical aging process,

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40

Lopes, Maria José Cardoso. "Characterization of the glial scar tissue in a murine model of spinal cord compression, with focus on hyaluronan." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15683.

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Mestrado em Biologia Molecular e Celular<br>Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of people each year. Although in recent decades significant progress has been made in relation to understanding the molecular and cellular events underlying the nervous damage, spinal cord injury is still a highly disabling condition for which there is no curative therapy. People affected by spinal cord injuries manifested dysfunction or loss, temporary or permanent, of motor, sensory and / or autonomic functions depending on the spinal lesion damaged. Currently, t

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Levine, Richard. "Evaluation of the Brainstem Spinal Cord Preparation in the Neonatal Rat as a Model for Prenatal Nicotine Exposure." The University of Arizona, 2012. http://hdl.handle.net/10150/623649.

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Class of 2012 Abstract<br>Specific Aims: The goal of this project was to evaluate the use of a preparation of the brainstem and spinal cord of neonatal rats that has been widely used for observing and quantifying central nervous activity, as well as the response to pharmacological manipulation. To achieve this, we specifically aimed to remove the intact brainstem and spinal cord of newborn rats, and develop a preparation that would maintain physiological function and allow for recording of electrical activity. Methods: Multiple dissections were performed on neonatal rats. Conditions during th

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42

Furmanski, Orion. "Manipulating Embryonic Neural Precursor Cells for Therapeutic Transplantation into a Rat Model of Neuropathic Pain." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/340.

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Persons with spinal cord injury (SCI) suffer life-long consequences including paralysis, loss of involuntary bodily functions, and chronic pain. A subset of SCI patients develop neuropathic pain (NP), a chronic condition resulting from damage to the spinal cord. Hyperexcitability of spinal cord sensory neurons near damaged tissue is believed to underlie SCI-related NP. Although many therapies have been employed clinically to combat SCI-NP, few give satisfactory long-term relief. Transplantation of cells that release GABA, a molecule that inhibits neuronal activity, is being explored as an alte

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Narayan, Sreenath. "REANIMATION OF A DENERVATED MUSCLE USING UPPER MOTONEURON INJURED LOWER MOTONEURONS IN SPINAL CORD INJURY PATIENTS: A RAT MODEL." online version, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1133754830.

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44

Sheehy, Susan Budassi. "A nurse-coached exercise intervention to increase muscle strength, improve quality of life, and increase self-efficacy in people with tetraplegic spinal cord injuries: A single subject design study." Thesis, Boston College, 2010. http://hdl.handle.net/2345/1411.

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Thesis advisor: Mary E. Duffy<br>Ten people with tetraplegic spinal cord injuries participated in a nurse-coached exercise intervention/single subject design study over a period of six months. Four pieces of exercise equipment were used: the RT300S Functional Electrical Stimulation Bike, the VIta Glide, the NuStep TRS 4000, and the Easy Stand Evolv Glider. Measurement of variables of the Manual Muscle Test (MMT), Catz-Itzkovich Spinal Cord Independence Measures (CI-SCIM), and Moorong Self-Efficacy Scale (MSES) were collected at baseline, at three months into the exercise intervention, and at s

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45

Starkey, Michelle Louise. "Strategies to promote repair and restore function after spinal cord injury : the mouse as an in vivo model system." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433905.

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46

Macaya, Daniel J. (Daniel Joseph). "Biomaterials-tissue interaction of an injectable collagen-genipin gel in a rodent hemi-resection model of spinal cord injury." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/84410.

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Thesis (Ph. D. in Medical Engineering and Medical Physics)--Harvard-MIT Program in Health Sciences and Technology, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Spinal cord injury (SCI) is a significant health issue resulting in life-long disability and associated secondary complications, affecting approximately 300,000 individuals in the United States. Primary barriers to functional recovery after SCI include the formation of a growth inhibitory astrocyte scar at the lesion border and a lack of a supportive stroma within the defect allowing for axon

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McHenry, Colleen Louise. "A biomechanical model of femoral forces during functional electrical stimulation after spinal cord injury in supine and seated positions." Thesis, University of Iowa, 2010. https://ir.uiowa.edu/etd/710.

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Following a spinal cord injury (SCI), the paralyzed extremities undergo muscle atrophy and decrease in bone mineral density (BMD) due in part to the loss of physiological loading. It is crucial to prevent musculoskeletal deterioration so the population is less susceptible to fractures, and could take advantage of stem cell treatment if it becomes available. Functional electrical stimulation (FES) has been shown to advantageously train the paralyzed extremities. However, there is a risk of fracture during FES due to low BMD of individuals with SCI. Therefore, the forces generated during FES nee

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Scesa, G. "MOLECULAR ASPECTS OF THERAPEUTIC ACTION OF 3° TRIMESTER AMNIOTIC FLUID CELLS IN A MOUSE MODEL OF SPINAL CORD INJURY." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/245779.

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Spinal cord injury (SCI) is a disabling degenerative disease that heavily impacts on patient's life. To date, treatments available are mostly vain, thought to target the inflammatory processes sustaining the secondary damage: in this scenario, the use of stem cells represents a promising new therapeutic strategy as it might permit a complete recovery of the patient through a regeneration of damaged nerve fibers. Among the different type of stem cells available, we focused on 3° trimester amniotic fluid-derived cells (Afs), verifying their potential therapeutic activity on a mouse model of SCI.

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Russell, Colin Macdonald. "A nonlinear finite element model of the rat cervical spine : validation and correlation with histological measures of spinal cord injury." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43119.

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Abstract:

Researchers and clinicians do not currently use the heterogeneity of the primary mechanism of spinal cord injury (SCI) to tailor treatment strategies because the effects of these distinct patterns of acute mechanical damage on long-term neuropathology have not been fully investigated. Computational modelling of SCI enables the analysis of mechanical forces and deformations within the spinal cord tissue that are not visible experimentally. I created a dynamic, hyperviscoelastic three-dimensional finite element (FE) model of the rat cervical spine and simulated contusion and dislocation SCI mech

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Tüngler, Victoria [Verfasser]. "Progesterone's activity in the central nervous system : a murine model study on Gliotoxin injured Myelin of the spinal cord / Victoria Tüngler." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2011. http://d-nb.info/1029846049/34.

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