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Relevant bibliographies by topics / Spinal cord development / Dissertations / Theses

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Dissertations / Theses on the topic 'Spinal cord development'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Lim, Siew-Na. "Development of novel therapeutic strategies in spinal cord injury using rodent models of spinal cord compression injury." Thesis, Queen Mary, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538663.

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2

Glasgow, Stacey Marie. "The role of PTF1A in spinal cord development." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=155.

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3

Gibson, Claire. "Interactions between afferent pathways in spinal cord development." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311132.

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4

Wicher, Grzegorz. "Clusterin and Megalin in The Spinal Cord." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7365.

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5

Urch, Catherine. "Post-natal development of nociceptive transmission : the role of the NMDA receptor complex." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270184.

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6

Rottkamp, Catherine Anne-Marie. "The Role of Hox Cofactors in Vertebrate Spinal Cord Development." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1194575822.

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7

Werndle, Melissa Cheng-Hwa. "Development of a novel technique to measure and characterise spinal cord perfusion pressure in patients with acute traumatic spinal cord injury." Thesis, St George's, University of London, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675934.

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Background There is no method in clinical use for measuring intraspinal pressure (ISP) and spinal cord perfusion pressure (SCPP) after traumatic spinal cord injury (TSCI) in humans. I hypothesised monitoring ISP and optimising SCPP may improve spinal cord function after injury. The thesis was performed in three stages. Methods (1) I ascertained the views of consultant neurosurgeons and neuroanaesthetists on the acute management of TSCI , via a survey. (2) A pressure probe was placed subdurally at the injury site in 18 patients with severe TSCI. Recording commenced within 72 hours of injury and

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8

Farah, Carl. "Connectivity of dI3 Interneurons In the Development of Mice Spinal Cord." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35752.

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Maturation of motor control, including movements that can be autonomously generated by spinal circuits, relies on the development of key inputs to spinal circuitry. In particular, the development of supraspinal, sensory and motor fibers come together to form organized spinal circuits capable of producing skilled movements that are volitionally controlled. Primitive reflexes such as the palmar grasp reflex (PGR) are known to disappear during development; presumably giving way to more volitional control of hand grasping. However, the underlying changes to the spinal circuitry responsible for thi

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9

Mather, Nicole K. "The development of the major brainstem decussations." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365330.

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10

Gou, Fàbregas Myriam. "Spinal cord motoneurons,morphological and molecular study during development and pathology." Doctoral thesis, Universitat de Lleida, 2010. http://hdl.handle.net/10803/8105.

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La identificació dels mecanismes moleculars que regulen la supervivència i mort de les motoneurones representa una informació important per a la comprensió funcional i l'establiment de potencials dianes terapèutiques per a les malalties que cursen amb degeneració i mort d'aquestes neurones. Per aquest motiu hem dedicat aquest treball a:<br/>a) L'estudi dels mecanismes intracel·lulars dependents de calci que modulen la supervivència de les motoneurones durant el desenvolupament.<br/>Com a efecte inductor de supervivència hem analitzat la participació de la proteïna quinasa dependent de Ca2+/Cal

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11

Erschbamer, Matthias. "Spinal cord injury : development of protection and repair strategies in rats /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-267-5/.

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12

Canizares, Marco. "Anatomy and development of the mouse spinal cord stem cell niche." Thesis, University of Dundee, 2018. https://discovery.dundee.ac.uk/en/studentTheses/976910c5-9564-48e3-ab9e-fecf325841ee.

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13

Rogers, A. T. "Spinal cord cell culture : a model for neuronal development and disease." Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234048.

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14

Rigato, Chiara. "Role of microglial cells during the mouse embryonic spinal cord development." Paris 6, 2013. http://www.theses.fr/2013PA066326.

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Le but de mon projet de thèse a été d’investiguer le rôle des cellules microgliales in vivo au cours du développement. On s’est particulièrement intéressés au développement de la moelle épinière car ce modèle a été bien caractérisé. Nous avons trouvé que les microglies colonisent la moelle épinière embryonnaire grâce à leur migration et prolifération. A E12. 5 les microglies s’accumulent transitoirement au point d’insertion des ganglions de la racine dorsale et phagocytent les axons apoptotiques des neurones sensoriels. A E13. 5 les microglies interagissent avec les glies radiaires, expriment

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15

Lim, Tit Meng. "Segmentation in the nervous system of the chick embryo." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329053.

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16

Van, Ryswyk Liesl, and Ryswyk Liesl Van. "A Question of Identity: Genes that Distinguish Motoneurons from Interneurons." Thesis, University of Oregon, 2012. http://hdl.handle.net/1794/12539.

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The question of how a single cell can grow, divide, and ultimately acquire a distinct function within an adult animal is central to the field of developmental biology. An elegant way to address this question is by studying the specification of a specific cell type, for example, vertebrate motoneurons. For an animal to be able to move and behave appropriately, individual motoneurons (MNs) must correctly innervate specific muscles. For this to happen, MNs must first be specified and then must differentiate into distinct subtypes, each of which is classified in part by the muscle it innervates. M

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17

Fallah, Zahra. "Development and plasticity of markers for inhibitory neurotransmission in the spinal cord." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244467.

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18

Gormley, Ann Marie. "Transgenic approaches to studying the development of sensory and spinal cord neurons." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244742.

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19

Rinaldi, Lucrezia. "Novel functions for Hox proteins in the development of the spinal cord." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0261/document.

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Les gènes Hox codent des facteurs de transcription à homéodomaines conservés qui coordonnent la spécification de l'identité régionale du corps pendant le développement des animaux bilatériens. Au nombre de 39 chez les vertébrés supérieurs, ils sont organisés en 4 complexes (A à D) sur les chromosomes. Treize groupes de gènes paralogues occupent des positions, des modes d'expression et des fonctions similaires. En plus de leurs fonctions spécifiques, des études récentes ont mis en évidence des fonctions "génériques", communes en dehors des groupes de paralogie. L'objectif de cette thèse était d

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20

Goode, Stephen Thomas. "Development of a spinal cord injury model using the material point method." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/17561/.

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Spinal cord injury (SCI) is characterised by permanent loss of motor and sensory function. The primary damage from the initial mechanical insult is exacerbated by the secondary patho-physiological cascade. Research into neuroprotective interventions to preserve tissue and reduce the damage caused by the secondary injury is hampered, in part, due to a lack of understanding of the link between the biomechanics of the primary traumatic injury and the subsequent evolution of the secondary injury. Hence, there is a need to better understand the biomechanics of SCI, the distinct injury patterns prod

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21

McGrath, Michael Anthony. "Development of novel therapeutics and in vitro models for spinal cord injury." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7651/.

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Spinal cord injury (SCI) is a devastating condition, which results from trauma to the cord, resulting in a primary injury response which leads to a secondary injury cascade, causing damage to both glial and neuronal cells. Following trauma, the central nervous system (CNS) fails to regenerate due to a plethora of both intrinsic and extrinsic factors. Unfortunately, these events lead to loss of both motor and sensory function and lifelong disability and care for sufferers of SCI. There have been tremendous advancements made in our understanding of the mechanisms behind axonal regeneration and r

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22

Rottkamp, Catherine Anne-Marie. "The role of Hox cofactors in vertebrate spinal coed development." Cleveland, Ohio : Case Western Reserve University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1194575822.

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23

Schaeffer, Julia. "The molecular regulation of spinal nerve outgrowth." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/271632.

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During amniote embryogenesis, the segmented pattern characteristic of the vertebral column appears early during development through the sequential formation of multipotent structures called somites. Somites differentiate subsequently into dermomyotome (giving rise later to skin and skeletal muscles) and sclerotome (giving rise to vertebral bone structures and cartilage). In addition, sclerotomes subdivide following their rostro-caudal intrasegmental boundary into an axon growth-permissive region (anterior half) and an axon growth-repulsive region (posterior half). This binary system instructs

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24

Ross, Lewis. "The development of an in vitro model of spinal cord injury using microfabrication." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4365/.

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This project aimed to develop an in vitro model of spinal cord injury. A device was developed that could, in conjunction with an existing myelinating culture system, aligned axons into parallel rows and contain the soma to a predefined area; thus creating a structure similar to the spinal cord. It was intended for the device to be simple to produce and use, provide easy accesses to the axons for wounding and allow simple measurement of axonal regrowth. An additional aim of the project was to develop a method of cell wounding that was reproducible, precise and allowed observation of the woundin

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25

Schertenleib, Denis. "The role of retinoid receptors in the development of the mouse spinal cord." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314089.

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26

Ogura, Takenori. "Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells." Kyoto University, 2019. http://hdl.handle.net/2433/236613.

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27

Mysiak, Karolina Sandra. "The role of monoamines in the development and regeneration of the zebrafish spinal cord." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25855.

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The hallmark of an adult mammalian central nervous system is the inability to regenerate after an injury. Zebrafish, on the other hand, have an astounding regenerative capacity. After a spinal cord lesion, zebrafish can re-establish the damaged neuronal network and regain their swimming ability within weeks. This is partly due to the presence of the ependymal radial glia (ERGs), which line the wall of the central canal and act as the stem/progenitor cells of the spinal cord. Under homeostatic conditions the ERGs are largely quiescent, however, the lesion triggers them to proliferate and replac

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28

Hall, Anita Caroline. "Platelet-derived growth factor and its alpha receptor subunit in oligodendrocyte development." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313676.

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29

Withers, Michelle Dawn. "Regulation of glycine receptors by embryonic rat spinal cord neurons during development in vitro." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187369.

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This work addresses developmental regulation of neurotransmitter receptors in the vertebrate central nervous system (CNS). Glycine receptors (GlyR) play a major role in inhibitory neurotransmission in the spinal cord. Changes in the types of GlyRs being expressed by embryonic rat spinal cord neurons are examined during development in vitro. Spinal cord neurons are cultured at the fourteenth day of gestation, prior to receiving afferent input. Previous work demonstrated a delayed expression of the adult-type GlyR α subunits. Reverse transcriptase-polymerase chain reaction demonstrates the prese

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30

Rodger, Damien Craig Burdick Joel Wakeman Tai Yu-Chong. "Development of flexible parylene-based microtechnologies for retinal and spinal cord stimulation and recording /." Diss., Pasadena, Calif. : California Institute of Technology, 2008. http://resolver.caltech.edu/CaltechETD:etd-11132007-223407.

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31

Swinnen, Nina. "Microglia in the embryonic brain and spinal cord during the development of neuronal networks." Paris 6, 2013. http://www.theses.fr/2013PA066321.

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Les cellules microgliales sont les cellules immunitaires résidentes du système nerveux central (SNC). Elles peuvent déjà être détectées au début du développement embryonnaire du SNC. Dans ce projet de recherche nous avons étudié l'invasion et les caractéristiques phénotypiques des cellules microgliales du cerveau embryonnaire. Nos résultats demontrent que les microglies dans le cortex embryonnaire ont un phénotype de « repos »; elles expriment peu de marqueurs d'activation et n'ont presque aucun canaux K+ à rectification entrante. Pourtant, elles sont très dynamiques comme dans le cerveau adul

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32

Eldahan, Khalid C. "TARGETING MALADAPTIVE PLASTICITY AFTER SPINAL CORD INJURY TO PREVENT THE DEVELOPMENT OF AUTONOMIC DYSREFLEXIA." UKnowledge, 2019. https://uknowledge.uky.edu/physiology_etds/41.

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Vital autonomic and cardiovascular functions are susceptible to dysfunction after spinal cord injury (SCI), with cardiovascular dysregulation contributing to morbidity and mortality in the SCI population. Autonomic dysreflexia (AD) is a condition that develops after injury to the sixth thoracic spinal segment or higher and is characterized by potentially dangerous and volatile surges in arterial pressure often accompanied with irregular heart rate, headache, sweating, flushing of the skin, and nasal congestion. These symptoms occur in response to abnormal outflow of sympathetic activity from t

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33

Spitzbarth, Ingo [Verfasser]. "A morphological and molecular investigation on the spatio-temporal development of spinal cord lesions following spinal injury in dogs / Ingo Spitzbarth." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1030453330/34.

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34

Joshi, Mital. "Development and characterization of a graded, in vivo, compressive, murine model of spinal cord injury." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/MQ54138.pdf.

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35

Schulte, Claus Josef. "The function of transcription factor Evx1 in spinal cord and fin development in Danio rerio." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609130.

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36

Uzel, Sébastien G. M. "Microfluidic and optogenetic technologies to model spinal cord development and neuromuscular junction formation and function." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/103850.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2015.<br>"June 2015." Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 106-118).<br>Motor neurons located in the spinal cord and innervating muscle cells throughout the body are responsible for virtually all motor functions, from locomotion to respiration or speech. They arise from differentiation of progenitor cells within the neural tube under spatiotemporally well-defined morphogen concentration profiles, and extend axons into the peripheral nervous system followin

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37

Chalfouh, Chaima. "Effet de la stimulation magnétique répétitive trans-spinale comme thérapie non invasive dans le cadre des lésions médullaires. The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury Resident neural stem cells guarantee the regeneration promoted by bulbar olfactory ensheathing cell transplantation after spinal cord injury." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMR099.

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Les lésions de la moelle spinale constituent un problème de santé public d’une ampleur grandissante. Bien que l’espérance de vie ait été améliorée, les patients médullo-lésés souffrent de certains handicaps entraînant une perte partielle ou complète des fonctions sensorielles et/ou motrices. La moelle spinale lésée entreprend aussitôt une réponse à cette lésion. Chronologiquement, la lésion se divise en deux grandes phases : la phase primaire qui se caractérise par la destruction tissulaire induite par le traumatisme mécanique, suivie d’une destruction cellulaire. Alors que la phase secondaire

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38

Hanson, Martin Gartz. "The embryonic neural circuit mechanism and influence of spontaneous rhythmic activity in early spinal cord development /." Connect to online version, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1085515804.

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39

Cope, Clinton D. "Development of a Concept Wheelchair for the Elderly." Thesis, Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14629.

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This thesis describes the research, design, and development of a mid-drive wheelchair for use by the elders living independently, in assisted living facilities, and in nursing homes created by a design team at Georgia Tech's Center for Assistive Technology and Environmental Access (CATEA). This wheelchair stands to significantly improve the mobility of elders through better drive wheel placement and design features that could stand to improve their quality of life.

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40

Hamilton, L. "Development of a computer-assisted system for the analysis of canine locomotion following spinal cord injury." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603616.

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This project aimed to develop an objective, quantitative system for assessing canine locomotion that would enable sensitive detection of changes following thoracolumbar spinal cord injury (SCI), with the eventual aim of using this to analyse the effects of an autologous olfactory ensheathing cell (OEC) transplant. Using a motion capture camera system, data analysis methods were developed which enabled objective assessment of the dog’s pelvic limb motion. Measures were developed which were independent of potential variables as size, breed and concurrent orthopaedic conditions. Locomotion was as

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41

Razzak, Rima Abdul. "Postnatal development of electrical activity in the hamster spinal cord studied in an in vitro preparation." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316424.

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42

Hanson, Martin Gartz Jr. "THE EMBRYONIC NEURAL CIRCUIT: MECHANISM AND INFLUENCE OF SPONTANEOUS RHYTHMIC ACTIVITY IN EARLY SPINAL CORD DEVELOPMENT." Case Western Reserve University School of Graduate Studies / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=case1085515804.

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43

Olby, Natasha J. "An experimental model of rat spinal cord injury : its development and studies on manipulation of its glial environment." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243014.

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44

Schafer, Carol Linda. "Development of a functional neuromuscular stimulation (FNS) muscle training program to prepare paraplegics for standing." Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/25845.

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Wheelchair-bound paraplegics are in an unnatural, almost all-day sitting position. This is physiologically disadvantageous as it may cause increased abdominal pressure, renal dysfunction, pressure sores, muscle atrophy and osteoporosis. Thus it would be beneficial, physiologically and psychologically, for a paraplegic to be able to stand for temporary periods of time. As a result of the muscle atrophy and functional degeneration that follows a spinal cord injury, it is essential for paraplegics to undergo a muscle restrengthening program, using Functional Neuromuscular Stimulation (FNS), befor

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45

Jamieson, Lindsay Patricia. "Development and assessment of novel methods of exercise testing during treadmill gait in incomplete spinal cord injury." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/3195/.

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The main study of this thesis monitors changes in cardiopulmonary fitness, peak voluntary force and CAR of the quadriceps and hamstring muscles, and lower limb BMD in two incomplete SCI subjects who participated in a 20-week BWS treadmill training (BWSTT) programme. The main outcomes of the BWSTT study were: a substantial improvement in performance parameters (training work rate, peak work rate (WRpeak) and the distance walked in 15 minutes), an overall increase in VO2peak and peak heart rate (HRpeak), a substantial decrease in ?VO2/?WR and a decrease in the VO2 and HR associated with a step i

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46

Tudor, Sarah Marie. "The Development of an Adaptive Driving Simulator." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5597.

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The ability to drive a car is an important skill for individuals with a spinal cord injury to maintain a high quality of life, particularly their freedom and independence. However, driving with a physical disability often requires the installation of an adaptive driving system to control steering, gas, and braking. The two main types of adaptive driving controls are mechanical and electrical, also known as drive by wire (DBW). DBW controls work by converting electric signals to mechanical actuators. Driving simulators are useful tools for adaptive driving systems because they allow users to te

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47

Roussel, Yann. "Development of Spinal Circuits for Swimming in Zebrafish (DANIO RERIO) LARVAE. Emphasizing on the Rhythm Generation Mechanism." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38069.

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It has long been established that the spinal cord is able to produce locomotor activity on its own. Despite extensive research identifying and describing the involvement of multiple spinal neuron populations that are part of the spinal locomotor circuit, the manner in which these different components act together to precisely control the rhythm and the pattern of activation of muscles during locomotion remains largely undetermined. We sought to shed light on how the components of spinal locomotor circuits interact to produce robust locomotion using a developmental approach in zebrafish larvae.

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48

Tawse, Holly. "An investigation into Canadian wheelchair rugby coaches: their role in the development of athletes with a spinal cord injury." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97242.

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The purpose of this study was to explore wheelchair rugby coaches lived experiences in the development of their athletes who had acquired a spinal cord injury (SCI). Four elite wheelchair rugby coaches in Canada were interviewed using a semi-structured open-ended interview format. Smith and Osborn's (2008) Interpretative Phenomenological Approach (IPA) was used to inductively analyze and interpret the data. Results revealed three higher-order categories: (a) Coach Attributes and Development, highlighted the evolution of the coaches and their methods of knowledge acquisition in the sport of whe

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49

McRae, J. "Dysphagia following acute cervical spinal cord injury (DAISY) : identification of current practice and development of a swallow screening tool." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10046891/.

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Cervical spinal cord injury (CSCI) patients have complex needs, often requiring tracheostomy, ventilation and surgery. These multiple factors have been linked to the development of oropharyngeal dysphagia with reported incidences of 8-80%. Resulting complications include respiratory impairment, increased morbidity and prolonged length of stay in an intensive care unit (ICU). This delays transfer to specialised units for on-going rehabilitation. Currently there is no clinical guidance for the effective identification and management of oropharyngeal dysphagia following CSCI. The aim of the DAISY

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50

Rauscent, Aude. "Remaniements fonctionnels des réseaux locomoteurs spinaux au cours du développement de l’amphibien Xenopus laevis en métamorphose." Thesis, Bordeaux 1, 2008. http://www.theses.fr/2008BOR13750/document.

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La plasticité du système nerveux central face aux contraintes environnementales ou morphologiques est un processus fondamental mis en place afin de permettre à l’animal de maintenir des comportements adaptés. Parce que le comportement locomoteur est essentiel à la survie de l'animal, les mécanismes neuronaux permettant sa genèse doivent s’adapter aux modifications morphologiques de l’organisme pendant son développement. Pour aborder cette question, nous avons développé un nouveau modèle expérimental pour lequel les modifications morphologiques au cours du développement sont extrêmes et impliqu

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