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Journal articles on the topic 'Spinal cord, diseases, treatment'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Caplan, L. R. "SPINAL CORD DISEASES—DIAGNOSIS AND TREATMENT." Brain 122, no. 9 (1999): 1793–94. http://dx.doi.org/10.1093/brain/122.9.1793-a.

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2

HALL, G. "Spinal Cord Diseases-Diagnosis and Treatment." Journal of Neurology, Neurosurgery & Psychiatry 67, no. 1 (1999): 132d. http://dx.doi.org/10.1136/jnnp.67.1.132d.

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3

Wang, Wen. "Spinal Cord Diseases: Diagnosis and Treatment." Journal of Chemical Neuroanatomy 25, no. 3 (2003): 229. http://dx.doi.org/10.1016/s0891-0618(03)00008-5.

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Choriyeva, Nilufar O'ktam qizi. "SPINAL CORD COMPRESSION." Multidisciplinary Journal of Science and Technology 5, no. 1 (2025): 38–39. https://doi.org/10.5281/zenodo.14621786.

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Spinal cord compression is a serious neurological condition characterized by pressure on the spinal cord, which can result in a range of symptoms including pain, numbness, motor weakness, and, in severe cases, paralysis. This article explores the etiology, clinical presentation, diagnostic methods, and management strategies for spinal cord compression. Common causes include traumatic injuries, tumors, infections, and degenerative diseases such as herniated discs or osteoarthritis. Timely diagnosis using imaging techniques like MRI and CT scans is crucial for effective treatment, which may incl

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Kuleshov, A. A., A. N. Shkarubo, Il’ya S. Gromov, et al. "Surgical treatment for nontumorous diseases of craniovertebral region." N.N. Priorov Journal of Traumatology and Orthopedics 25, no. 1 (2018): 36–41. http://dx.doi.org/10.17816/vto201825136-41.

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Purpose: to evaluate the efficacy of surgical treatment for the non-tumorous diseases of the craniovertebral region. Patients and Methods. Forty five patients aged 4 - 63 years (mean age 27 years) with non-tumorous diseases of the craniovertebral region were operated on. Either one- or two-step surgical interventions for spinal cord decompression were performed. Early and long term results were evaluated by Frankel, JAO and River scales. In 5 cases the assessment of volumetric craniovertebral interrelationships (VCVI). Results. Good results were obtained in 43 (96%) patients at terms from 1 to

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Zhu, Ping, Jia-xin Li, Masayuki Fujino, Jian Zhuang, and Xiao-Kang Li. "Development and Treatments of Inflammatory Cells and Cytokines in Spinal Cord Ischemia-Reperfusion Injury." Mediators of Inflammation 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/701970.

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During aortic surgery, interruption of spinal cord blood flow might cause spinal cord ischemia-reperfusion injury (IRI). The incidence of spinal cord IRI after aortic surgery is up to 28%, and patients with spinal cord IRI might suffer from postoperative paraplegia or paraparesis. Spinal cord IRI includes two phases. The immediate spinal cord injury is related to acute ischemia. And the delayed spinal cord injury involves both ischemic cellular death and reperfusion injury. Inflammation is a subsequent event of spinal cord ischemia and possibly a major contributor to spinal cord IRI. However,

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Kuleshov, A. A., A. N. Shkarubo, I. S. Gromov, et al. "SURGICAL TREATMENT FOR NON-TUMOROUS DISEASES OF CRANIOVERTEBRAL REGION." Vestnik travmatologii i ortopedii imeni N.N. Priorova, no. 1 (June 23, 2018): 36–41. http://dx.doi.org/10.32414/0869-8678-2018-1-36-41.

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Purpose:to evaluate the efficacy of surgical treatment for the non-tumorous diseases of the craniovertebral region.Patients and Methods. Forty five patients aged 4 – 63 years (mean age 27 years) with non-tumorous diseases of the craniovertebral region were operated on. Either one- or two-step surgical interventions for spinal cord decompression were performed. Early and long term results were evaluated by Frankel, JAO and River scales. In 5 cases the assessment of volumetric craniovertebral interrelationships (VCVI).Results.Good results were obtained in 43 (96%) patients at terms from 1 to 15

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Li, Qi, Longji Xu, Chunyan Hu, et al. "Direct Jet Co-Electrospinning of Spinal Cord-Mimicking Phantom for Diffusion Magnetic Resonance Imaging." Coatings 14, no. 5 (2024): 520. http://dx.doi.org/10.3390/coatings14050520.

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(1) Background: Spinal cord injuries and diseases necessitate sophisticated tools for accurate diagnosis and treatment planning. However, the lack of reliable phantoms mimicking the complex structure of the spinal cord hinders the development and validation of advanced imaging techniques. This study aims to address this critical unmet need by exploring the application of electrospinning to create polymeric fibers resembling the human spinal cord; (2) Methods: Direct jet coaxial electrospinning (DJ-co-ES) is a specialized electrospinning process characterized by the presence of solely the strai

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Hashimoto, Shogo, Narihito Nagoshi, Masaya Nakamura, and Hideyuki Okano. "Regenerative medicine strategies for chronic complete spinal cord injury." Neural Regeneration Research 19, no. 4 (2023): 818–24. http://dx.doi.org/10.4103/1673-5374.382230.

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Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by trauma or various diseases. While rapid progress has been made in regenerative medicine for spinal cord injury that was previously untreatable, most research in this field has focused on the early phase of incomplete injury. However, the majority of patients have chronic severe injuries; therefore, treatments for these situations are of fundamental importance. The reason why the treatment of complete spinal cord injury has not been studied is that, unlike in the early stage of incomplete spinal cord inju

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Jami, Sayed Abdulla, Shi Jiandang, Zhanwen Zhou, and Liu Chang Hao. "REVIEW OF THE SPINAL TUBERCULOSIS SURGICAL TREATMENT AND OUTCOMES." Romanian Journal of Clinical Research 3, no. 1 (2020): 24–30. http://dx.doi.org/10.33695/rjcr.v3i1.48.

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Spinal tuberculosis (TB), caused by mycobacterium tuberculosis, is one of the oldest diseases in the world. Spinal TB represents 50% of bone and joint TB. If spinal TB is not diagnosed and treated in time, it could cause spinal cord infection, nerve compression and paralysis. Spinal TB often causes abscesses formation, spinal dysfunction, spinal instability, and kyphosis onset disorder. Most spinal TB can be cured by non-surgical treatment. Surgery is the ultimate method of treatment of spinal tuberculosis and it is used for eliminating lesions, relieving spinal cord and nerve compression, cor

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Negrin, Arianna, Scott Schatzberg, and Simon R. Platt. "The Paralyzed Cat." Journal of Feline Medicine and Surgery 11, no. 5 (2009): 361–72. http://dx.doi.org/10.1016/j.jfms.2009.03.004.

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Practical relevance Although gait disturbance is one of the most common neurological presentations in feline medicine, the clinical approach to the paralyzed cat can be challenging. After excluding orthopedic and cardiovascular diseases that may mimic a neurological condition, the clinician has to address a long list of different diseases that may affect the spinal cord and produce paresis. Clinical challenges In many cases a definitive cause of spinal weakness in cats is difficult to prove. Even when treatable diseases are identified, the prognosis is very much dependent on the severity of th

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Demchenko, Anna A., and Nikolay A. Kozlov. "Occurrence of comorbid spinal column diseases in dogs with cervical spondylomyelopathy." Veterinariya, Zootekhniya i Biotekhnologiya 5, no. 114 (2023): 6–12. http://dx.doi.org/10.36871/vet.zoo.bio.202305001.

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Cervical spondylomyelopathy or Wobbler's syndrome is a common disease of the cervical spine in dogs of large and giant breeds. When diagnosing this disease, one cannot exclude the possibility of a patient having two or more comorbid pathologies of the spinal column, since their presence may adversely affect the results of treatment. It is necessary to make a comprehensive diagnosis of patients to identify all diseases and prescribe the subsequent most effective treatment. This article presents the incidence of various diseases of the spinal column and spinal cord simultaneously with cervical s

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Marrodan, Mariano, María I. Gaitán, and Jorge Correale. "Spinal Cord Involvement in MS and Other Demyelinating Diseases." Biomedicines 8, no. 5 (2020): 130. http://dx.doi.org/10.3390/biomedicines8050130.

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Diagnostic accuracy is poor in demyelinating myelopathies, and therefore a challenge for neurologists in daily practice, mainly because of the multiple underlying pathophysiologic mechanisms involved in each subtype. A systematic diagnostic approach combining data from the clinical setting and presentation with magnetic resonance imaging (MRI) lesion patterns, cerebrospinal fluid (CSF) findings, and autoantibody markers can help to better distinguish between subtypes. In this review, we describe spinal cord involvement, and summarize clinical findings, MRI and diagnostic characteristics, as we

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Bulankina, Irina A., Marina I. Gubina, Lyudmila O. Gutsol, et al. "MORPHOLOGICAL ORGANIZATION OF THE SPINAL CORD AND ITS RELATIONSHIP WITH SOME PATHOLOGICAL CONDITIONS (LECTURE 1) (FROM THE CYCLE OF «CENTRAL NERVOUS SYSTEM»)m the cycle of «Central Nervous System»)." Baikal Medical Journal 4, no. 1 (2025): 58–74. https://doi.org/10.57256/2949-0715-2025-4-1-58--74.

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Background. The spinal cord is an important part of the central nervous system, and its functions are closely related to maintaining the functioning of organs and ensuring interaction between body’s organ systems. The spinal cord plays a major role in the transmission of information between effector organs and the brain, being a conductor of impulses. Knowledge of the morphological organization of the spinal cord is necessary for students of medical universities, neurologists, and neuroscientists, since the functions performed by the spinal cord are closely related to the preservation of its a

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Karan, Vedrana, Djula Djilvesi, Mladen Karan, Vladimir Papic, and Petar Vulekovic. "Use of intraoperative neurophysiological monitoring in surgical treatment of spinal diseases." Srpski arhiv za celokupno lekarstvo 147, no. 7-8 (2019): 502–5. http://dx.doi.org/10.2298/sarh180709076k.

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Intraoperative neurophysiological monitoring (IONM) is a method, which uses different kinds of electrophysiological methods for monitoring and mapping of neural structures during surgical procedures with the aim to preserve them. If we know how important the function of the spine, spinal cord, nerve roots, and all other structures are, it is obvious how important it is to preserve them in surgical procedures where these structures are under risk. Although the frequency of neurological complications is not high, it is considered that these deficits are devastating complications of spinal surger

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Gogu, Anca Elena, Agneta Pusztai, Alina Zorina Stroe, Daniel Docu Axelerad, and Any Docu Axelerad. "Back Pain in Rare Diseases: A Comparison of Neck and Back Pain between Spinal Cord Ischemia and Spinal Dural Arteriovenous Fistula." Brain Sciences 10, no. 9 (2020): 618. http://dx.doi.org/10.3390/brainsci10090618.

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Neck and back pain may be noted like a first symptom in rare diseases: spinal cord ischemia and spinal dural arteriovenous fistula (SDAVF). Spinal cord ischemia is a rarer pathology, compared with cerebral ischemia, yet the morbidity and mortality are comparable in both cases; furthermore, classifying the acute loss of function in the spine, encountered in spinal cord ischemia as an important neurological entity. SDAVF presents the same clinical symptoms as spinal cord ischemia, but even though it has a progressive character, the impact in the quality of patients’ lives being equally as import

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17

Maeda, Hiroyuki. "Utility of thermographic evaluation in spinal cord stimulation therapy DTM workflow for thoracolumbar compression fracture and lumbar spinal canal stenosis." International Physical Medicine & Rehabilitation Journal 8, no. 1 (2023): 103–5. http://dx.doi.org/10.15406/ipmrj.2023.08.00342.

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Among the orthopedic conditions that cause low back pain, many patients with thoracolumbar compression fractures and lumbar spinal canal stenosis caused by osteoporosis visit orthopedic surgeons. However, many patients do not respond to analgesics or nerve block injections, and many are at risk or unwilling to undergo surgery due to age or underlying disease. We believe that spinal cord stimulation therapy is a new treatment option for orthopedic low back and leg pain. We have performed spinal cord stimulation for chronic intractable pain in patients with thoracolumbar spine compression fractu

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Nolan, John, and Tjokorda Gde Bagus Mahadewa. "Infectious diseases as complications following spinal cord injury." Neurologico Spinale Medico Chirurgico 4, no. 1 (2021): 1–6. http://dx.doi.org/10.36444/nsmc.v4i1.122.

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Background: Infectious complications in spinal cord injury (SCI) patients can increase the mortality and morbidity of the patients. The inability to do daily activity is the main cause of the occurrence of infectious complications. Good understanding and high awareness are needed to notice some infectious complications which are difficult to be diagnosed. Method: This paper is a literature review which was done by reviewing and searching journals with “infectious complication”, “spinal cord injury”, “infection” on the search engines. The authors found 52 articles are suitable to be compo

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Towne, Brooke V., Carol B. Girgiss, and Nathaniel M. Schuster. "Use of spinal cord stimulation in treatment of intractable headache diseases." Pain Medicine 24, Supplement_2 (2023): S6—S10. http://dx.doi.org/10.1093/pm/pnad090.

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Abstract Headache diseases remain one of the leading causes of disability in the world. With the development of neuromodulation strategies, high cervical spinal cord stimulation (hcSCS) targeting the trigeminocervical complex has been deployed to treat refractory headache diseases. In this article, we review the proposed mechanism behind hcSCS stimulation, and the various studies that have been described for the successful use of this treatment strategy in patients with chronic migraine, cluster headache, and other trigeminal autonomic cephalalgias.

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Yiwen, Li, and Luo Guiqing. "Overview of Traditional Chinese Medicine Treatment for Four Common Cervical Diseases." Research and Inheritance of Traditional Chinese Medicine 2, no. 2 (2024): 55–58. http://dx.doi.org/10.62022/ricm.issn3005-5482.2024.02.010.

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Cervical diseases refer to various clinical syndromes caused by damage or degeneration of the bones, joints, intervertebral discs, and soft tissues around the vertebrae of the cervical spine, which, under certain triggering conditions, result in dislocation of spinal joints, protrusion of intervertebral discs, calcification of ligaments, or bone hyperplasia, directly or indirectly stimulating or compressing the spinal nerve roots, vertebral arteries and veins, spinal cord, or sympathetic nerves. Cervical headache, cervical tinnitus, cervical hypertension, and cervical periarthritis are four co

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Kawabata, Soya, Koji Akeda, Junichi Yamada, et al. "Advances in Platelet-Rich Plasma Treatment for Spinal Diseases: A Systematic Review." International Journal of Molecular Sciences 24, no. 8 (2023): 7677. http://dx.doi.org/10.3390/ijms24087677.

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Spinal diseases are commonly associated with pain and neurological symptoms, which negatively impact patients’ quality of life. Platelet-rich plasma (PRP) is an autologous source of multiple growth factors and cytokines, with the potential to promote tissue regeneration. Recently, PRP has been widely used for the treatment of musculoskeletal diseases, including spinal diseases, in clinics. Given the increasing popularity of PRP therapy, this article examines the current literature for basic research and emerging clinical applications of this therapy for treating spinal diseases. First, we revi

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Ma, Xiaoyu, and Juejin Wang. "Research progress on the role of ginsenoside Rd in central nervous system diseases." African Health Sciences 24, no. 4 (2025): 325–31. https://doi.org/10.4314/ahs.v24i4.41.

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Ginsenoside Rd (GSRd) is one of the rare saponin monomers extracted from ginseng. Most importantly, GSRd could effectively cross the intact blood-brain barrier (BBB). Studies have shown that it plays an important role in the treatment of neurological diseases such as ischemic stroke (IS), spinal cord injury (SCI), Alzheimer's disease (AD) and Parkinson's disease (PD). The results of these studies are of great significance for the clinical application of GSRd in the treatment in neurological diseases. This article reviewed the protective effects of GSRd in central nervous system diseases and an

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23

MIHĂILESCU, Gabriela. "Spinal cord tumor hidden by comorbidities." Romanian Journal of Medical Practice 10, no. 4 (2015): 400–403. http://dx.doi.org/10.37897/rjmp.2015.4.16.

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Comorbidities present in complex cases can frequently hide new diseases, may influence treatment decisions and can augment risks. The nonvalvular atrial fibrillation is a risk factor for inducing stroke, but treated with anticoagulant drugs in a right way atrial fibrillation is not responsible for the onset of all new motor deficits in a patient. The anamnesis, the thorough clinical neurological examination, associated with specific paraclinical diagnosis methods can lead to the right diagnosis, showing, in this specific case presented, a meningioma of the spinal cord localised in the high cer

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Liana Yuza, Iftitah, Marto Sihombing, and Siswan Syahputra. "THE CERTAINTY FACTOR METHOD IN DISEASES OF THE SPINAL NERVES." Journal of Mathematics and Technology (MATECH) 2, no. 2 (2023): 193–205. https://doi.org/10.63893/matech.v2i2.162.

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The spinal cord is a canal of the brain that runs from the neck to the coccyx. This nerve plays an important role in the process of sending signals from the brain to the rest of the body and vice versa. If this nerve is damaged, there will be interference with some body functions, such as the loss of the ability to move or feel things. Spinal cord patients should be treated immediately by a specialist doctor who deals with problems in neurological diseases. If treatment is not done immediately, the patient may need a longer recovery period. In addition, the possibility of worsening the conditi

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Ju, Chang Il, Seok-won Kim, Pius Kim, and Seung Myung Lee. "Prevalence of Cervical and Thoracic Spinal Disease: A Systematic Review." Journal of Minimally Invasive Spine Surgery and Technique 8, no. 1 (2023): 9–20. http://dx.doi.org/10.21182/jmisst.2023.00731.

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Objective: This study aimed to comprehensively assess the prevalence and distribution of degenerative cervical and thoracic diseases with compression of the spinal cord, such as disc herniation (TDH) or hypertrophied ligamentum flavum causing stenosis, by reviewing the literature. Methods: We searched PubMed/MEDLINE to identify articles on the prevalence of degenerative diseases with compression of the spinal cord in the cervical and thoracic spine. The levels of evidence were classified according to the NASS 2005 method. We selected articles containing information on the prevalence of degener

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Moncomble, Laurine, Pauline Neveu, Clémence Raimond, and Nicolas Guérout. "Magnetic stimulation techniques for the treatment of central nervous system lesions: a narrative review." Advanced Technology in Neuroscience 2, no. 1 (2025): 34–46. https://doi.org/10.4103/atn.atn-d-24-00021.

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Neuromodulation has experienced significant growth in recent years. This technique modulates the activity of the central or peripheral nervous system via electrical or magnetic fields. It can be applied to peripheral nerves, the spinal cord, or the brain. Historically, spinal cord stimulation has been used for chronic pain management, with electrodes surgically placed around the spinal cord via a method known as epidural spinal cord stimulation. Recently, this technique has been improved for the treatment of spinal cord injuries. In the brain, deep brain stimulation targets the basal ganglia a

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27

Zhang, Peng, Christian Hölscher, and Xun Ma. "Therapeutic potential of flavonoids in spinal cord injury." Reviews in the Neurosciences 28, no. 1 (2017): 87–101. http://dx.doi.org/10.1515/revneuro-2016-0053.

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AbstractSpinal cord injury (SCI) is a catastrophic event that can profoundly affect a patient’s life, with far-reaching social and economic effects. A consequential sequence of SCI is the significant neurological or psychological deficit, which obviously contributes to the overall burden of this condition. To date, there is no effective treatment for SCI. Therefore, developing novel therapeutic strategies for SCI is highly prioritized. Flavonoids, one of the most numerous and ubiquitous groups of plant metabolites, are the active ingredients of traditional Chinese medicine such as Scutellaria

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Gazizov, Ilnaz M., Andrey A. Izmailov, Elmira A. Elagina, and Zufar Z. Safiullov. "Umbilical cord blood stem cells: transplantation prospects in neurological practice." Neurology Bulletin LVI, no. 2 (2024): 181–96. http://dx.doi.org/10.17816/nb626625.

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Umbilical cord blood has evolved from being considered a mere cellular/tissue waste product after childbirth to a valuable biological material with a wide regenerative potential. Today, hematopoietic cord blood stem cells are used in the same way as bone marrow and mobilised peripheral blood as part of the standard medical treatment for haemoblastoses and hereditary blood diseases. There is an increasing amount of experimental data showing possibility of umbilical cord blood cell fractions using for treatment of non-hematological diseases and, in particular, diseases of the central nervous sys

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Evzikov, G. Yu, R. I. Abdrafiev, and V. N. Argylova. "Surgical treatment of spinal neurenteric cysts." Russian journal of neurosurgery 26, no. 3 (2024): 126–34. http://dx.doi.org/10.17650/1683-3295-2024-26-3-126-134.

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Background. Spinal neurenteric cysts are very rare benign space-occupying lesions in the vertebral canal emerging due to anomalies of neural tube development during prenatal development of the fetus. Clinically, neurenteric cysts can manifest both in childhood and adulthood.Aim. To evaluate the results of surgical treatment of adult patients with spinal neurenteric cysts who were operated on at the Neurosurgery Division of the Clinic of Nervous System Diseases of the I.M. Sechenov First Moscow State Medical University.Materials and methods. The study group included 3 patients (2 women and 1 ma

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Wang, James. "Neurospinal Surgery Innovations." Translational Neuroscience and Clinics 3, no. 3 (2017): 121–22. http://dx.doi.org/10.18679/cn11-6030_r.2017.020.

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Over the past few decades, majority of neurosurgeons only specialize in spinal cord diseases. However, with the advances in spine surgery, more and more neurosurgeons focus on spine diseases. Precision minimally invasive technique in surgery of spine and spinal cord is an important branch of neurosurgery. As traditional surgery has been gradually replaced by precision surgery, open surgery has been gradually replaced by minimally invasive surgery (MIS), the diagnosis and treatment of spine diseases has been benefiting from minimally invasive techniques. With minimal surgical trauma, precise lo

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Sobirova, Nozila. "RISK AND TREATMENT OF SYMPTOMS OF TUMOR DISEASES IN CHILDREN." MODERN SCIENCE AND RESEARCH 3, no. 1 (2024): 1142–47. https://doi.org/10.5281/zenodo.10604284.

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<em>Brain tumors make up to 20% of malignant tumor diseases in children. These tumors differ from each other in their structure and characteristics. In children, medullablastomas (tumors that develop independently), as well as astrocytomas (malignant tumors of the central nervous system), glioblastomas that arise in the spinal cord, and ependymoma tumors that develop in the internal spaces of the brain are found in children.</em>

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Yang, Xiaokai, Shuai Liu, and Zhengqiang Wang. "Ononin Alleviates Sublesional Bone Loss and Inflammation Following Spinal Cord Injury in Rats by Regulating Adenosine 5′-Monophosphate-Activated Protein Kinase Signaling Pathway." Current Topics in Nutraceutical Research 20, no. 4 (2022): 648–53. http://dx.doi.org/10.37290/ctnr2641-452x.20:648-653.

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Inhibition of bone loss is one of the ways to alleviate motor dysfunction caused by spinal cord injury, a lifelong and lifechanging injury. Isoflavone from legumes that include ononin, Calycosin-7-O-β-Glucoside, and others have been shown to have potential for the treatment of orthopedic diseases. While there are potentials for ononin to improve the motor function of spinal cord injury, studies on the subject are lacking. To this end, we examined the ameliorative role of ononin in an animal model of spinal cord injury. Our results show the ononin reduced inflammatory response, decreased femora

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Kaminiów, Konrad, Izabella Ryguła, and Justyna Paprocka. "Ataxia in Neurometabolic Disorders." Metabolites 13, no. 1 (2022): 47. http://dx.doi.org/10.3390/metabo13010047.

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Ataxia is a movement disorder that manifests during the execution of purposeful movements. It results from damage to the structures of the cerebellum and its connections or the posterior cords of the spinal cord. It should be noted that, in addition to occurring as part of many diseases, pediatric ataxia is a common symptom in neurometabolic diseases. To date, there are more than 150 inherited metabolic disorders that can manifest as ataxia in children. Neuroimaging studies (magnetic resonance imaging of the head and spinal cord) are essential in the diagnosis of ataxia, and genetic studies ar

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Lattanzi, Simona, Francesco Logullo, Paolo Di Bella, Mauro Silvestrini, and Leandro Provinciali. "Multiple sclerosis, solitary sclerosis or something else?" Multiple Sclerosis Journal 20, no. 14 (2014): 1819–24. http://dx.doi.org/10.1177/1352458514535129.

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Background: Inflammatory demyelinating diseases of the central nervous system represent a wide spectrum of entities and their classification cannot currently be regarded complete. Objective: Our aim is to describe a series of patients presenting with progressive myelopathy associated to a single demyelinating lesion of the spinal cord. Methods: We identified the patients affected by chronic progressive spinal cord dysfunction related to a single spinal cord lesion not satisfying the diagnostic criteria for any of the currently defined diseases. Results: Seven females and one male were included

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Tondiy, O. L., O. Yu Sukhonosova, S. M. Korenev, and O. V. Kunta. "Hereditary diseases with predominantly affecting pyramidal pathways — spastic paraplegia (clinical lecture)." Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini 2025, no. 1 (2025): 107–17. https://doi.org/10.15407/internalmed2025.01.107.

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The article summarizes the issues of modern classification, clinical course, manifestations, diagnostics and symptomatic treatment of hereditary diseases with predominant damage to the pyramidal tracts at the level of the spinal cord — spastic paraplegias

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Nemeth, Colin, Naren L. Banik, and Azizul Haque. "Disruption of Neuromuscular Junction Following Spinal Cord Injury and Motor Neuron Diseases." International Journal of Molecular Sciences 25, no. 6 (2024): 3520. http://dx.doi.org/10.3390/ijms25063520.

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The neuromuscular junction (NMJ) is a crucial structure that connects the cholinergic motor neurons to the muscle fibers and allows for muscle contraction and movement. Despite the interruption of the supraspinal pathways that occurs in spinal cord injury (SCI), the NMJ, innervated by motor neurons below the injury site, has been found to remain intact. This highlights the importance of studying the NMJ in rodent models of various nervous system disorders, such as amyotrophic lateral sclerosis (ALS), Charcot–Marie–Tooth disease (CMT), spinal muscular atrophy (SMA), and spinal and bulbar muscul

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Sanivarapu, Raghavendra, Vijayalakshmi Vallabhaneni, and Vivek Verma. "The Potential of Curcumin in Treatment of Spinal Cord Injury." Neurology Research International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/9468193.

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Current treatment for spinal cord injury (SCI) is supportive at best; despite great efforts, the lack of better treatment solutions looms large on neurological science and medicine. Curcumin, the active ingredient in turmeric, a spice known for its medicinal and anti-inflammatory properties, has been validated to harbor immense effects for a multitude of inflammatory-based diseases. However, to date there has not been a review on curcumin’s effects on SCI. Herein, we systematically review all known data on this topic and juxtapose results of curcumin with standard therapies such as corticoster

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Cai, Jiacheng, and Zhide Zheng. "Different Modalities and Parameters in Spinal Cord Stimulation Treatment." Transactions on Computer Science and Intelligent Systems Research 5 (August 12, 2024): 40–45. http://dx.doi.org/10.62051/9rxn6218.

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Electrical stimulation to treat diseases can be tranced back to the pharaonic era. Since then, people have found using the electrical pulse generated by electric cat-fish can mange the patient’s pain effectively. Foreign studies started early, and the technology was relatively mature. Spinal cord stimulation was produced in the 1960s by inserting stimulating electrodes into the spinal canal's epidural area. At the same time, the pulse generator was implanted subcutaneously to achieve the purpose of pain treatment with electrical pulses. This article will introduce three main types of stimulati

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Deng, Junhao, Fanqi Meng, Kexue Zhang, et al. "Emerging Roles of Microglia Depletion in the Treatment of Spinal Cord Injury." Cells 11, no. 12 (2022): 1871. http://dx.doi.org/10.3390/cells11121871.

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Microglia, as the resident immune cells and first responder to neurological insults, play an extremely important role in the pathophysiological process of spinal cord injury. On the one hand, microglia respond rapidly and gather around the lesion in the early stage of injury to exert a protective role, but with the continuous stimulation of the injury, the excessive activated microglia secrete a large number of harmful substances, aggravate the injury of spinal cord tissue, and affect functional recovery. The effects of microglia depletion on the repair of spinal cord injury remain unclear, an

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Lee, Anthony W., and Julie G. Pilitsis. "Spinal cord stimulation: indications and outcomes." Neurosurgical Focus 21, no. 6 (2006): 1–6. http://dx.doi.org/10.3171/foc.2006.21.6.6.

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✓Spinal cord stimulation (SCS) is the most commonly used implantable neurostimulation modality for management of pain syndromes. In this paper the authors describe the current indications for SCS and its efficacy in the treatment of those diseases. Specifically, the literature on patient selection and outcomes after SCS for failed–back surgery syndrome (FBSS), refractory angina pectoris, peripheral vascular disease, and complex regional pain syndrome (CRPS) Type I was reviewed. Effective pain relief was obtained in 60 to 80% of patients with FBSS and CRPS Type I. Furthermore, these patients ha

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Kajikawa, Keita, Narihito Nagoshi, Osahiko Tsuji, et al. "Clinical and Imaging Characteristics of Non-Neoplastic Spinal Lesions: A Comparative Study with Intramedullary Tumors." Diagnostics 12, no. 12 (2022): 2969. http://dx.doi.org/10.3390/diagnostics12122969.

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The features of non-neoplastic lesions are often similar to those of intramedullary tumors, and a differential diagnosis is challenging to obtain in some cases. A surgical biopsy, which is performed on highly invasive tumors, should be avoided in cases of non-neoplastic lesions. Therefore, an accurate diagnosis is important prior to treatment. We evaluated 43 patients suspected of having spinal cord tumors and, finally, were diagnosed with non-neoplastic intramedullary lesions via magnetic resonance imaging. The patients commonly presented with myelitis. The patients with non-neoplastic neurol

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Smith, Paige, Min Choi, Danielle Charron, Ranjith Ramesh, and Meaghan O'Reilly. "Ultrasound-enhanced drug delivery to spinal cord tumors." Journal of the Acoustical Society of America 151, no. 4 (2022): A152. http://dx.doi.org/10.1121/10.0010942.

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The blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) are major obstacles to the treatment of CNS diseases and disorders as they prevent the passage of most therapeutic agents from the blood pool to the CNS tissue. Transient, reversible opening of the BBB using ultrasound and microbubbles (MBs) has been extensively studied and has reached clinical investigations. Ultrasound and MBs can similarly modify the BSCB, although applications in the spinal cord have received less attention. We have previously demonstrated ultrasound and MB-mediated opening of the BSCB in rodents, as well a

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Snishuk, Viktor P., Maria D. Vladovskaya, Sergey V. Vissarionov, Nikolay A. Krutelev, Alexander V. Kaminskiy, and Irina S. Petrova. "Selected aspects of the epidemiology of tumors and tumor-like diseases of the spine and spinal cord in children: A 19-year regional cohort study in the Leningrad region." Pediatric Traumatology, Orthopaedics and Reconstructive Surgery 6, no. 2 (2018): 44–53. http://dx.doi.org/10.17816/ptors6244-53.

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Background. Statistical analysis of spinal tumors in children is difficult because of its rarity and different morphology. Benign tumor and tumor-like processes are not included in modern oncology literature even though intracanal tumors have the most severe prognosis and influence on a patient’s quality of life. Aim. To evaluate the incidence, epidemiological structure (anatomical, sex, morphological structure), clinical characteristics, and survival of pediatric patients with tumors and tumor-like diseases of the spine and spinal cord in a single region of Russia. Materials and m

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Sivanesan, Eellan, Dermot P. Maher, Srinivasa N. Raja, Bengt Linderoth, and Yun Guan. "Supraspinal Mechanisms of Spinal Cord Stimulation for Modulation of Pain." Anesthesiology 130, no. 4 (2019): 651–65. http://dx.doi.org/10.1097/aln.0000000000002353.

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Abstract The field of spinal cord stimulation is expanding rapidly, with new waveform paradigms asserting supraspinal sites of action. The scope of treatment applications is also broadening from chronic pain to include cerebral ischemia, dystonia, tremor, multiple sclerosis, Parkinson disease, neuropsychiatric disorders, memory, addiction, cognitive function, and other neurologic diseases. The role of neurostimulation as an alternative strategy to opioids for chronic pain treatment is under robust discussion in both scientific and public forums. An understanding of the supraspinal mechanisms u

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Konoplyannikov, M. A., V. P. Baklaushev, V. A. Kalsin, M. A. Tikhonovsky, and A. V. Averyanov. "CELL THERAPY OF STROKE AND SPINAL CORD INJURY COMPLICATIONS." Journal of Clinical Practice 6, no. 3 (2015): 48–58. http://dx.doi.org/10.17816/clinpract6348-58.

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The review analyzes the current advances of cell therapy for neurological complications of ischemic stroke and spinal cord injury (SCI). We demonstrate the most recent data on the use of different types of stem cells for the treatment of these severe damages, obtained both in experimental studies using animal models and in clinical studies. We particularly discuss the use of mesenchymal stem cells (MSC) and neural stem/progenitor cells (NSC/NPC) for the treatment of stroke and SCI. We also discuss the prospects for a further development of cell therapy of these diseases.

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Cui, Yinjie, Jingyi Liu, Xiao Lei, et al. "Dual-directional regulation of spinal cord injury and the gut microbiota." Neural Regeneration Research 19, no. 3 (2023): 548–56. http://dx.doi.org/10.4103/1673-5374.380881.

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Abstract There is increasing evidence that the gut microbiota affects the incidence and progression of central nervous system diseases via the brain-gut axis. The spinal cord is a vital important part of the central nervous system; however, the underlying association between spinal cord injury and gut interactions remains unknown. Recent studies suggest that patients with spinal cord injury frequently experience intestinal dysfunction and gut dysbiosis. Alterations in the gut microbiota can cause disruption in the intestinal barrier and trigger neurogenic inflammatory responses which may imped

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Halder, Sebok K., and Richard Milner. "Spinal Cord Blood Vessels in Aged Mice Show Greater Levels of Hypoxia-Induced Vascular Disruption and Microglial Activation." International Journal of Molecular Sciences 24, no. 14 (2023): 11235. http://dx.doi.org/10.3390/ijms241411235.

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In response to chronic mild hypoxia (CMH, 8% O2), spinal cord blood vessels launch a robust angiogenic response that is associated with transient disruption of the blood–spinal cord barrier (BSCB) which, in turn, triggers a microglial vasculo-protective response. Because hypoxia occurs in many age-related conditions, the goal of this study was to define how aging influences these responses by comparing events in young (8–10 weeks) and aged (20 months) mice. This revealed that aged mice had much greater (3–4-fold) levels of hypoxic-induced BSCB disruption than young mice and that, while the ear

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Thietje, Roland, Birgitt Kowald, Ralf Böthig, et al. "Long-Term Survival and Causes of Death in Patients below the Age of 60 with Traumatic Spinal Cord Injury in Germany." Journal of Clinical Medicine 11, no. 1 (2021): 26. http://dx.doi.org/10.3390/jcm11010026.

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To study the mortality, cause and risk indicators of death in German patients with traumatic spinal cord injury, patients with traumatic spinal cord injury admitted to Berufsgenossenschaftliches Trauma Hospital Hamburg between 1 January 1997 and 31 December 2018, aged between 16 and 60 with a minimal survival of one year after injury, were included. Further criteria were the absence of life-limiting comorbidities at the time of injury. 223 deceased patients with traumatic spinal cord injury were identified, investigated on and partly compared to the surviving subjects. We aimed to discover spe

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AYGÜN BİLECİK, Nilüfer. "Neuropathic Pain in Spinal Cord Injuries." Cukurova Anestezi ve Cerrahi Bilimler Dergisi 6, no. 1 (2023): 140–46. http://dx.doi.org/10.36516/jocass.1243810.

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Aim: Spinal cord injury (SCI) is a destructive condition causing additional physical, psychological, and social function disorders. Neuropathic pain (NP) following SCI is a common and challenging problem to treat. The addition of the NP following SCI increases the impairment of the sleep patterns, moods, and daily life activities of the patients. Treatment of NP following SCI is often difficult and often requires a long time to respond to treatment. The study aimed to investigate the neuropathic pain condition in patients with SCI. Methods: The study included 52 patients with spinal cord

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Filchugova, K. O., and D. V. Kibkalo. "Efficacy of transcutaneous microcurrent electrical stimulation in the treatment of neurogenic bladder atony in dogs with spinal cord injuries." Veterinary Medicine: inter-departmental subject scientific collection, no. 110 (October 23, 2024): 249–57. https://doi.org/10.36016/vm-2024-110-40.

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The aim of the study was to evaluate the effectiveness and impact of paravertebral myoelectric stimulation on the possibility of increasing bladder tone in neurogenic bladder atony in dogs with spinal cord injuries. Dysfunction of the bladder and lower urinary tract is one of the most common complications in traumatic and therapeutic spinal diseases in dogs. As a result of the compressive effect of the traumatic factor on the spinal cord, chain processes in the body are initiated, resulting in pathological dysfunction of the bladder and urinary tract. This pathology is called neurogenic bladde

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