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1

J, Brull Sorin, ed. Physiology of spinal anesthesia. 4th ed. Baltimore, Md: Williams & Wilkins, 1993.

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2

Spinal and epidural anesthesia. New York: McGraw Hill Medical, 2007.

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3

R, Macintosh R. Sir Robert Macintosh's Lumbar puncture and spinal analgesia: Intradural and extradural. 5th ed. Edinburgh: Churchill Livingstone, 1985.

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4

1939-, Krämer Jürgen, ed. Spinal injection techniques. Stuttgart: Thieme, 2009.

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5

Robert, MacIntosh. Sir Robert Macintosh's Lumbar puncture and spinal analgesia: Intradural and extradural. 5th ed. Edinburgh: Churchill Livingstone, 1985.

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6

Anesthesia for spine surgery. Cambridge: Cambridge University Press, 2012.

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7

Hans, Renck, ed. Handbook of thoraco-abdominal nerve block. Orlando: Grune & Stratton, 1987.

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8

Interventional and neuromodulatory techniques for pain management. Philadelphia: Elsevier/Saunders, 2012.

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9

Cepunov, Boris, Konstanciya Gozhenko, and Evgeniy Zhilyaev. Surgery. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1048569.

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The tutorial consists of two sections. The section "General surgery" covers the issues of prevention of surgical infection, issues of anesthesia, organization of preoperative and postoperative periods and other issues of general surgery (blood transfusion, transfusion, open and closed injuries, types of operative and non-operative surgical techniques, surgical infection, tumors). Attention is paid to general disorders of the vital activity of the body, as well as resuscitation, emergency care in case of accidents. The section "Specific types of surgical pathology" describes injuries and diseases of the head and neck, chest, abdominal cavity, spine and pelvis, limbs, peripheral vessels and nerves. Much attention is paid to the care of surgical patients at all stages of treatment. The principles and methods of providing first medical and pre-medical care in critical conditions of the patient are described in detail. The final chapter is devoted to the technique of surgical manipulations. Meets the requirements of the federal state educational standards of secondary vocational education of the latest generation. It is intended for students of paramedic, obstetric and nursing departments of medical colleges and colleges.
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10

Lee, J. Alfred, Margaret J. Watt, and R. S. Atkinson. Sir Robert MacIntosh's Lumbar Puncture and Spinal Analgesia. Churchill Livingstone, 1986.

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11

Macintosh, R. R. Sir, 1897-, Lee J. Alfred, Atkinson R. S, and Watt Margaret J, eds. Sir Robert Macintosh's Lumbar puncture and spinal analgesia: Intradural and extradural. 5th ed. Edinburgh: Churchill Livingstone, 1985.

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12

Wong, Cynthia. Spinal and Epidural Anesthesia. McGraw-Hill Professional, 2006.

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13

S, Porter Susan, ed. Anesthesia for surgery of the spine. New York: McGraw-Hill, Inc., Health Professions Division, 1995.

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14

Pajewski, Thomas N. Anesthesia for Anterior/Posterior Spine Surgery. Edited by David E. Traul and Irene P. Osborn. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190850036.003.0011.

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Surgical approaches to correct spine pathology are based on anatomical considerations along with a surgeon’s experience and preference. Beyond consideration of the actual anatomic level being addressed, the different areas of the spinal column, cervical, thoracic, lumbar, and sacral coccygeal regions are in proximity of a range of structures that must be appreciated during surgery. These considerations impact the anesthetic management of the surgical patient. Historically, spine pathology was initially approached posteriorly, but, since the mid-twentieth century, the anterior approach has been more frequently used, especially at the cervical level. Advances in surgical techniques, coupled with advances in anesthesia and postoperative care, have allowed an increasing patient population to benefit from surgical interventions that address various forms of spinal pathology, including neurological dysfunction, deformity (either hereditary or acquired), structural instability, pathologic lesions (including tumor and infections), and pain.
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15

Nguyen, Kim-Phuong, and Chris D. Glover. Anesthetic Considerations for Scoliosis Repair. Edited by Erin S. Williams, Olutoyin A. Olutoye, Catherine P. Seipel, and Titilopemi A. O. Aina. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190678333.003.0032.

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Scoliosis is an anatomical deformity caused by a lateral and rotational shift in the thoracolumbar spine. Surgical correction involves wide exposure of the spine for placement of stabilizing rods and can result in significant complications from excessive blood loss and neurologic impairments. These procedures require vigilance to acid-base status, hemodynamic fluctuations, coagulation, temperature maintenance, and neurologic monitoring from anesthesiologists. Other major anesthetic considerations discussed include maintaining the integrity of perfusion to the spinal cord, positioning concerns, optimal technique for neuromonitoring, and pain control in the perioperative period. This chapter presents a case study of a 14-year-old girl with adolescent idiopathic scoliosis who presents for posterior spinal instrumentation and fusion from T4-L4 with autologous bone graft.
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16

Waters, Janet. A Woman in Labor with Hypotension and Dyspnea After Epidural Placement. Edited by Angela O’Neal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190609917.003.0022.

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This chapter discusses neurological complications of the administration of epidural and spinal anesthesia in the obstetric population. It begins with a case report on a patient with a total spinal block, which occurs when large doses of local anesthetic intended for the epidural space are inadvertently injected into the subarachnoid space. The chapter reviews key points in recognizing and treating this potentially fatal complication. It discusses other complications, including epidural hematoma, epidural abscess, spinal cord injury, and meningitis, as well as complications from intravascular injection of local anesthetic. Lastly, it discusses how to recognize and treat the most common complication of neuraxial block, post dural puncture headache.
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17

Narinder, Rawal, and Coombs Dennis W, eds. Spinal narcotics. Boston: Kluwer Academic Publishers, 1990.

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18

Ellis, Wayne Enoch. DETERMINING PROFICIENCIES IN SPINAL ANESTHESIA USING THE DELPHI TECHNIQUE (ANESTHESIA PROGRAMS, NURSE ANESTHESIA PROGRAM). 1990.

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19

Patil, Arati, and Sophie R. Pestieau. Anesthetic Management of Scoliosis Surgery in Children. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0029.

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Scoliosis is defined as an abnormal curvature of the spine, which, if severe enough, can affect pulmonary or cardiac function and ultimately require surgical repair. There are 3 well-defined types of scoliosis: idiopathic, neuromuscular, and congenital scoliosis. Anesthetic management of children undergoing posterior spinal fusion can be challenging due to patient comorbidities, the need for neuromonitoring, the potential for significant blood loss, and various perioperative complications. In addition, postoperative pain after spinal fusion is known to be severe and often exceeds those reported in other major surgical procedures. To properly care for these patients, it is vital to be knowledgeable about the anesthetic and pain management considerations of patients undergoing posterior spinal fusion.
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20

Handbook of Spinal Anaesthesia and Analgesia. W.B. Saunders Company, 1994.

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21

Kaye, Alan, and Richard Urman, eds. Obstetric Anesthesia Practice. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780190099824.001.0001.

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Obstetrical Anesthesia Procedures provides timely updates in the field of obstetrical anesthesia and provides a concise, up-to-date, evidence-based and richly illustrated book for students, trainees, and practicing clinicians. The book comprehensively covers a robust list of topics focused to improve understanding in the field with emphasis on recent developments in clinical practices, technology, and procedures. This book describes all the essential topics that are required for the practitioner to quickly assess the patient and risk stratify them, decide on the type of analgesic and anesthetic plan that is most appropriate for the patient, its feasibility and safety, provide expert consultation to the other members of the obstetric team, manage anesthesia care and complications, and arrange for advanced care if needed. There are special considerations for pregnant patients undergoing non-obstetric surgery, anesthesia for assisted reproductive technologies, and anesthetic management of operations on placental support. It is also important to develop the skills needed to perform antenatal evaluation of high-risk parturients and understand the physiology of pregnancy and peripartum anesthetic implications of co-existing conditions involving hematologic, cardiac, neurological, renal, endocrine and pulmonary systems. There are also special considerations for parturients with pregnancy-induced hypertension, multiple gestations, abnormal fetal presentation, preterm labor, obstetric hemorrhage, and trauma in pregnancy. There are pharmacologic and non-pharmacologic pain management options for labor, caesarean delivery, and postoperative pain. This includes management of intravenous and oral analgesics, understanding of drug pharmacology and its effect on the mother and the baby, neuraxial techniques (spinal, epidural, combined spinal-epidural) and peripheral nerve blocks.
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22

Ballard, Heather, Ravi Shah, and Santhanam Suresh. Neuraxial Anesthesia and Analgesia for Pediatric Surgery. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0055.

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Neuraxial anesthesia has a long history of use in pediatric surgery. It can be used as a sole anesthetic or as an adjunct to sedation or general anesthesia. Neonatal spinals and single-shot caudal anesthesia are effective for lower abdominal, urological, and lower extremity orthopedic surgeries. When a thoracic, lumbar, or caudal epidural catheter is utilized, postoperative analgesia can also be provided to surgeries involving the chest and upper abdomen. There is renewed interest in neuraxial anesthesia due to concerns of the effect of volatile anesthetics on the developing brain. Though research studies on the long-term effects of volatile anesthetics are still inconclusive, neuraxial anesthesia has been shown to provide effective surgical anesthesia and postoperative analgesia. When used in combination with general anesthesia, it has the benefit of reducing the amount of sedatives required. The use of ultrasound may increase success and margin of safety.
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23

(Editor), Narinder Rawal, and Dennis W. Coombs (Editor), eds. Spinal Narcotics (Current Management of Pain). Springer, 1989.

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24

D, Alderson J., and Frost Elizabeth A. M, eds. Spinal cord injuries: Anaesthetic and associated care. London: Butterworths, 1990.

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25

Gugino, Laverne D., Rafael Romero, Marcella Rameriz, Marc E. Richardson, and Linda S. Aglio. TMS in the perioperative period. Edited by Charles M. Epstein, Eric M. Wassermann, and Ulf Ziemann. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780198568926.013.0020.

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Two stimulation approaches developed for selectively exciting descending motor pathways are, transcranial electrical (TES) and transcranial magnetic (TMS) stimulation. This article highlights the comparison between electrical and magnetic transcranial stimulation. Magnetic stimulation is relatively painless; therefore it is the more preferred technique. The article reviews the use of TMS for monitoring the functional integrity of the descending motor systems during surgery and discusses the potential role of TMS in the preoperative period for conscious patients planning to undergo neurosurgical procedures involving the cerebral cortex. Selective monitoring of spinal cord motor function involves acquisition of TMS-induced epidural and/or myogenic responses. As patients are generally given anesthesia before spinal cord surgeries, this article discusses the effect of general anesthetic agents on the myogenic responses.
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26

Local-spinal therapy of spasticity. Berlin: Springer-Verlag, 1988.

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27

Jameson, Leslie. Acute Loss of Intraoperative Evoked Potential Signals. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0069.

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Monitoring of somatosensory and motor evoked potentials has become the standard of care for a large proportion of spine surgeons. Understanding how anesthetic management may affect these evoked potentials is critical to optimizing the ability to detect impending spinal cord or peripheral nerve injury. Similarly, once a nerve injury is detected, knowledge of the various anesthetic and surgical maneuvers possible to avoid permanent injury is essential for the best patient outcomes. This chapter discusses the effects of various anesthetic agents on somatosensory and motor evoked potentials and potential critical interventions that can be made when a nerve injury is identified by this monitoring.
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28

Gofeld, Michael. Lumbar Transforaminal and Nerve Root Injections: Ultrasound. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199908004.003.0017.

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Ultrasound (US) guidance has gained recognition in the field of regional anesthesia mainly because of its definite advantage of visually localizing the desired target and also due to perceived benefits of safety, accuracy, and efficiency when peripheral nerve blocks are performed. On the contrary, ultrasonography of the spinal structures may be challenging because of depth, bony acoustic shadowing, and complex three-dimensional anatomy. Nevertheless, US allows satisfactory imaging of the posterior elements of spine column and paraspinal soft tissues. This makes US applicable and practical in the outpatient clinical setting, and thus ultrasonography has been increasingly penetrating into chronic spinal pain management. Perhaps the major advantage of ultrasound-guided spine interventions is the lack of radiation exposure. Lumbar transforaminal injections are frequently performed for managing acute and chronic radicular pain, and US guidance may reduce overall radioactive contamination.
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29

Katz, Jordan. Handbook of thoraco-abdominal nerve block. Prentice Hall, 1988.

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30

Peralta, Feyce. High or Total Spinal/Epidural. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0044.

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High or total spinal/epidural blockade occurs due to excess spread of local anesthetic within the neuraxial space. While this is an infrequent complication, it can cause respiratory and hemodynamic instability in obstetric patients. If high/total spinal/epidural occurs prior to delivery, such derangements may lead to fetal intolerance and need for emergency delivery. Clinicians should suspect risk for high block when patients lose upper extremity motor function and complain of dysphonia or dyspnea. Intubation and respiratory and hemodynamic support along with adequate sedation should be given until the block recedes. Preventative measures include strict epidural catheter aspiration practice and incremental epidural dosing strategies.
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31

Chen, Grace, and Ashley Valentine. Neuraxial Analgesia and Anesthesia in Chronic Opioid Users and Patients with Pre-existing Pain. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190457006.003.0007.

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Neuraxial anesthesia and analgesia are effective modalities for surgery and perioperative pain management, respectively. These techniques may have nonanalgesic benefits as well, including improved 30-day mortality benefit, decreased risk of perioperative pneumonia, decreased risk of persistent postoperative pain, and attenuation of the stress response to surgery with improved survival in certain cancers. Post-operative pain control with epidural can be especially beneficial for opioid tolerant chronic pain patients compared to enteral or parenteral analgesics alone. In patients with previous back surgery or scoliosis, neuraxial techniques may be technically difficult. However, there is no evidence to suggest neuraxial approaches worsen pre-existing back pain. The exceptions are a pathology that reduces spinal canal cross-sectional area (e.g., severe spinal stenosis) and spinal infection. Neuraxial techniques should be avoided in these patients. Preprocedural labs and imaging are dictated by patient comorbidities, medication, and anatomy (e.g. scoliosis or spinal column pathology).
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32

Meigh, Abigail E., Ingrid A. Fitz-James Antoine, and Veronica Carullo. Pediatric Spine Surgery. Edited by David E. Traul and Irene P. Osborn. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190850036.003.0016.

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In children, the most common indication for spinal fusion is significant scoliotic curvature, either idiopathic or as a result of neuromuscular disease. Spinal fusion is high-risk surgery, which can be further complicated by comorbid disease. It carries substantial risk for significant fluid shifts, high intraoperative blood loss, physiologic strain secondary to duration and positioning, severe postoperative pain, and potential spinal cord injury. To mitigate risk and optimize outcomes, these patients should be carefully evaluated by the anesthetic team preoperatively and a comprehensive perioperative plan established. To protect the spinal cord and predict poor neurologic outcomes, the majority of these cases employ intraoperative neuromonitoring. The specific anesthetic agents to allow maximal neuromonitoring signals while ensuring adequate anesthetic depth and pain control should also be established collaboratively. These patients experience severe postoperative pain, and a multimodal approach to therapy should be employed to allow for expedited recovery and decreased length of stay.
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33

Grant, Stuart A., and David B. Auyong. Trunk and Spine Ultrasound Guided Regional Anesthesia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190231804.003.0004.

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This chapter describes the clinical anatomy and outlines the tools and techniques needed to perform thoracic, abdominal and neuraxial ultrasound-guided procedures. The nerve blocks described here include the transversus abdominis plane (TAP), quadratus lumborum, ilioinguinal-iliohypogastric, rectus sheath, intercostal, PECS, serratus plane, paravertebral, and neuraxial spinal and epidural blocks. For each nerve block, the indications, risks, and benefits of the varying approaches are described in detail. The chapter includes step-by-step instructions with illustrations to allow the operator to perform clinically effective and safe ultrasound-guided thoracic, truncal, and neuraxial procedures. At the conclusion of each block description, a “Pearls” segment highlights important tips gleaned from our clinical experience. This chapter provides the practitioner with thorough instruction and knowledge allowing the optimal delivery of regional anesthesia for any thoracic or abdominal surgery.
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34

Grant, Stuart A., and David B. Auyong, eds. Ultrasound Guided Regional Anesthesia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190231804.001.0001.

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This clinically based, comprehensive textbook provides a detailed description of the most useful nerve blocks in ultrasound guided regional anesthesia. Four sections cover Basic Principles (including an appendix, “What Block for What Surgery?), Upper Limb Blocks, Lower Limb Blocks, and Trunk and Spine Blocks. The initial chapter provides a review of ultrasound physics that allows the practitioner to understand how to optimize the ultrasound machine to produce the best ultrasound images possible. This foundation, along with the clinical tips and step-by-step techniques for in-plane and out-of-plane needle guidance, make this instructive text useful for practitioners at all levels. The first chapter also includes seven Keys to Ultrasound Success and concludes with a clinical summary of which blocks to perform for specific surgeries or trauma situations. The specific blocks covered in the remaining chapters range from the classic femoral, interscalene, popliteal sciatic, and axillary blocks to more novel blocks such as the adductor canal, selective suprascapular, quadratus lumborum, and PECS blocks. Each block description includes a review of clinical anatomy, indications, positioning, and a step-by-step approach to ultrasound imaging and needle insertion. Ultrasound images are provided in both an unedited, clean version and a companion version that is clearly labeled, allowing the reader to compare the images side by side. Throughout the book, comprehensive photographs of ultrasound images, cadaver dissections, and patient positioning are provided, with vibrant, colorful annotations that significantly add to the clarity of instruction provided.
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35

Maurtua, Marco, Mathew Lyons, and Nicholas DaPrano. Chiari Malformations. Edited by David E. Traul and Irene P. Osborn. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190850036.003.0014.

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Chiari malformations are structural defects in the base of the skull and cerebellum. These conditions are characterized by the abnormal displacement of part of the cerebellum and brainstem through the foramen magnum into the upper spinal canal causing autonomic dysfunction, neurologic deficits, and hydrocephalus. Chiari malformations are classified into several types based on their severity and the parts of the brain affected by the herniation. In neonates, Chiari malformations are commonly associated with spina bifida and myelomeningocele. Anesthesia for surgical correction of Chiari malformations presents a unique set of challenges and demands that requires knowledge of both the neurophysiology of the condition and the surgical process.
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36

Otis, James A. D. Non-Opioid Pharmacotherapies for Chronic Pain (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190265366.003.0015.

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The objective of chapter 15 is to describe analgesic approaches to chronic pain, excluding opioids. As such, it emphasizes, first, the available pharmacotherapies; and then procedures. The pharmacotherapies divide into analgesics, such as non-steroidal anti-inflammatory drugs (NSAIDs); adjuvant analgesics, such as tricyclic antidepressants and anticonvulsants; oral anesthetic agents (cardiotropics); adrenergic agonists; topical agents such as capsaicin and local anesthetic solutions and ointments; and muscle relaxants such as cyclobenzaprine, tizanidine, and baclofen. Interventions include many best administered by anesthesiologists such as infusions of anesthetic agents; trigger point injections; local and regional blockade, spinal injections including corticosteroids; and electrical spinal cord stimulation. A text box is provided with additional resources.
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37

Chin, Ki Jinn. Central Neuraxial Blockade: Ultrasound. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199908004.003.0022.

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Successful central neuraxial blockade requires entry into the epidural or intrathecal space, and is contingent on the ability to guide a needle into the desired interlaminar space between adjacent vertebrae. Ultrasonography of the spine has been shown to be an effective tool for guiding epidural and spinal anesthesia. The use of ultrasound to central neuraxial blockade can broadly be divided into either preprocedural ultrasound imaging to delineate the underlying anatomy, or real-time ultrasound imaging of the needle as it is advanced toward the target. This chapter focuses only on preprocedural ultrasound imaging of the thoracic and lumbar spine, as real-time ultrasound-guided central neuraxial blockade is a challenging technique that requires much more investigation before it can be recommended for routine use. There is ample evidence to support the utility of ultrasound imaging of the spine in facilitating central neuraxial blockade. It is particularly useful in patients with challenging surface landmarks.
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38

Frawley, Geoff. Mucopolysaccharidoses. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0064.

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The mucopolysaccharidoses (MPS) are a group of seven chronic progressive diseases caused by deficiencies of 11 different lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs). Hurler syndrome (MPS IH) is an autosomal recessive storage disorder caused by a deficiency of α‎-L-iduronidase. Hunter syndrome (MPS II) is an X-linked recessive disorder of metabolism involving the enzyme iduronate-2-sulfatase. Many of the MPS clinical manifestations have potential anesthetic implications. Significant airway issues are particularly common due to thickening of the soft tissues, enlarged tongue, short immobile neck, and limited mobility of the cervical spine and temporomandibular joints. Spinal deformities, hepatosplenomegaly, airway granulomatous tissue, and recurrent lung infections may inhibit pulmonary function. Odontoid dysplasia and radiographic subluxation of C1 on C2 is common and may cause anterior dislocation of the atlas and spinal cord compression.
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39

Spaliaras, Joanne. Myelomeningocele. Edited by David E. Traul and Irene P. Osborn. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190850036.003.0017.

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Spina bifida is a defect in which the vertebral arch of the spinal column is either incompletely formed or absent. Failure of closure of the neural tube during the third week of gestation leads to the constellation of defects observed in patients with meningomyelocele or open spina bifida. Myelomeningocele is the most common neural tube defect and the most severe birth defect compatible with long-term survival. It is associated with several characteristic central nervous system anomalies. Leak of cerebrospinal fluid (CSF) is commonly observed. The major indication for early operative repair (within 48 hours of delivery) is prevention of infection. Protection of the exposed neural tissue from trauma and drying is essential. An understanding of the pathophysiology and associated conditions of myelomeningocele helps guide anesthetic management of these patients.
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40

Koht, Antoun, and Tod B. Sloan. Neurophysiologic Monitoring. Edited by David E. Traul and Irene P. Osborn. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190850036.003.0028.

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Intraoperative neurophysiologic monitoring is used for monitoring and mapping of neurological structures during surgery and procedures where the neurological structures are at risk. Among the most commonly used techniques are electrophysiologic techniques, which include spontaneous and evoked electromyography, somatosensory evoked potentials, motor evoked potentials, electroencephalography, and auditory brainstem responses. These methods differ in their responses to anesthesia and in their clinical contribution to monitoring because of differing anatomy. Their use in spinal corrective surgery highlights the role of the anesthesiologist during cases when these techniques are utilized. Optimization of anesthesia, position, and physiology provide better monitoring conditions, enhance signal evaluation, and may lead to better neurological outcome.
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41

Mavi, Jagroop, Anne C. Boat, and Senthilkumar Sadhasivam. Myelomeningocele Repair. Edited by Erin S. Williams, Olutoyin A. Olutoye, Catherine P. Seipel, and Titilopemi A. O. Aina. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190678333.003.0051.

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Myelomeningocele (MMC) is a spinal birth defect associated with significant morbidity directly related to the exposure of meninges and neural structures. Further neurological dysfunction may occur secondary to Chiari II malformation and hydrocephalus. MMC repair is typically performed postnatally within the first 24 to 48 hours of life due to the concern for infection. Prenatal MMC correction is performed in select cases after studies showed improved neurological outcomes. Anesthesia for MMC repairs can be challenging, and appropriate screening should be performed preoperatively. During postnatal repair, care must be taken when positioning the infant to avoid any pressure on the MMC sac. Anesthesia can be maintained with a combination of inhalational agents and intravenous opioids. Prenatal MMC repairs must consider both fetal and maternal safety outcomes. They can be performed through both open and fetoscopic routes, with anesthesia focused on maintaining maternal blood pressure, optimizing uterine relaxation, and adequate pain control.
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42

Moore, Michael R., and Ehab Farag. Unstable Cervical Spine and Airway Management. Edited by David E. Traul and Irene P. Osborn. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190850036.003.0012.

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In patients with cervical myelopathy, the spinal cord is already compromised to a point at which there is little reserve for surgical maneuvers and the slightest adverse action can result in dramatic consequences. Awake fiberoptic intubation and neurological assessment before induction of anesthesia could be the safest way to avoid waking up the patient before proceeding with surgery in the case of absent motor evoke potentials (MEPs) in spite of increasing the stimulating voltage together with increasing the rate of stimulating pulses. Hypotension is an additional factor, which may lead to irreversible neurologic deficit in a partially compressed but functionally intact spinal cord. Intraoperative neurophysiologic monitoring for cervical myelopathy should include somatosensory evoked potentials, transcranial electric MEPs, and electromyography to provide complementary information and monitor different spinal cord tracts and individual nerve roots.
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43

Boat, Anne C., and Senthilkumar Sadhasivam. Myelomeningocele Repair. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0056.

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Myelomeningocele (MMC) is a spinal birth defect that occurs due to failure in the closure of the embryologic neural tube. The meninges and/or neural structures are exposed, resulting in nerve damage. MMCs are associated with significant direct morbidity as well as with Chiari II malformations and hydrocephalus. The degree of sensory and motor deficits depends on the level of the defect, with bowel and bladder function often affected. Due to the risk of infection with an exposed spinal cord, surgical repair is usually performed in the first 24 to 48 hours of life. Anesthesia for MMC repair presents a unique challenge since positioning of these patients must prevent direct pressure on the exposed neural tissue.
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44

Rubin, Philip. Post–Dural Puncture Headache. Edited by Matthew D. McEvoy and Cory M. Furse. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190226459.003.0056.

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Post–dural puncture headache (PDPH) is a benign but debilitating condition that may occur as a consequence of any dural puncture, whether intentional (as with spinal anesthesia or lumbar puncture) or inadvertent (as with epidural anesthesia). The headache is characteristically unique, as it is postural in nature—worsened when sitting or standing, and markedly improved in the recumbent position. After the puncture, passage of cerebrospinal fluid (CSF) across the dura mater from a pressurized environment (subarachnoid space) to the epidural space, is the initial culprit behind the headache. Noninvasive conservative measures including hydration, analgesics, and caffeine intake are typically offered as initial treatments, but if those measures fail, the “gold standard” epidural blood patch is commonly offered. This procedure entails injection of autologous blood into the epidural space to both halt continued CSF “loss,” and to increase CSF pressure, both of which aid in headache resolution.
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45

Patino, Mario, and Anna M. Varughese. Osteogenesis Imperfecta. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0066.

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Osteogenesis imperfecta (OI) is a heterogeneous inherited disorder of type I collagen. Although it is most commonly known for the “brittle bones” that lead to multiple and recurrent fractures, OI has manifestations in other tissues where type I collagen is present. Moreover, the brain stem, cervical spine, and lungs can be affected indirectly due to the resultant bone abnormalities. A pre-anesthetic evaluation must review all systems and specific anesthetic considerations are necessary to reduce complications and improve outcomes of patients with OI.
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46

Thomas, Donna-Ann. Local Anesthetics. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190626761.003.0005.

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Local anesthetics, if utilized properly, can be a powerful tool in perioperative pain control. They are good adjuvants to traditional modes of anesthesia and analgesia while offering unique qualities of their own. Understanding the pharmacodynamics and pharmacokinetics of local anesthetics allows for utilization in the perioperative period that significantly improves patient pain control as well as the patient’s surgical experience. This chapter explores the mechanisms of action, the pharmacology and pharmacodynamics, the pharmacokinetics, and the clinical uses and toxicities for common local anesthetics, especially as these pertain to spinal surgery. In addition, detailed descriptions are given of common local anesthetics, along with dosing guidelines, contraindications, and side-effect profiles.
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47

Manuel, Solmaz P., Christine L. Mai, and Robert Brustowicz. Orthopedic Surgery. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199398348.003.0018.

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Anesthesia for pediatric orthopedic and spinal surgery presents multiple challenges for the anesthesiologist. Children often present with comorbidities and concomitant diseases that affect the respiratory and cardiovascular functions. Significant blood loss and prolonged operating times can pose significant risks. Airway management in a child with a syndrome can be both difficult and challenging. Orthopedic tumor surgery may be complicated by chemotherapy treatment, anesthetics can be affected by drug interactions, and postoperative pain management can be complex. In this chapter, we review common coexisting diseases in pediatric patients undergoing orthopedic surgeries. These diseases include syndromes such as Down syndrome, Marfan syndrome, and Klippel-Feil syndrome; muscular dystrophies such as Duchenne muscular dystrophy; and bony cancers such as osteosarcoma.
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48

Oliver, Jodi-Ann, Lori-Ann Oliver, Michael Casimir, and Caroline Walker. Pain Management for General Pediatric Surgery. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190457006.003.0013.

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As the misconception that children and infants do not experience pain in the same way as adults has been vastly discredited, the management of perioperative pain in the pediatric population has become a rapidly developing field. Inadequate treatment of perioperative pain in this population can lead to serious long-term or permanent sequela for not only the patients but also their families. Postoperative pain management in children is best accomplished using a multimodal approach in which different classes of drugs such as opioids (short or long acting), non-opioid adjuncts (nonsteroidal anti-inflammatory drugs, acetaminophen), and antineuroleptics (gabapentin) are used alone or in combination with regional anesthesia techniques (peripheral nerve blocks, caudals, epidurals, or spinals). When placed prior to surgical incision, the use of peripheral and central blocks is beneficial not only in decreasing the total opioid consumption in the perioperative period but also in preventing activation of pain pathways that are ultimately responsible for the development of chronic pain.
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van Eerd, Maarten, Arno Lataster, and Maarten van Kleef. Cervical Facet Nerve Block and Radio Frequency Ablation: Fluoroscopy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199908004.003.0007.

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In the cervical spinal column local anesthetic can be injected intra-articularly or adjacent to the ramus medialis (medial branch) of the ramus dorsalis of the segmental nerve. Nerve blocks of the ramus medialis are preferred to an intra-articular block, because it is sometimes technically difficult to position a needle into the facet joint. These procedures are typically performed under fluoroscopy, but there are increasing numbers of studies that describe these procedures with the help of ultrasound. Reports regarding the effects of intra-articular (steroid) injections are limited. There are no comparative studies between intra-articular steroid injections and radiofrequency (RF) therapy. Based on literature about the efficacy of RF treatment and a long track record of safety of RF treatment, many pain practitioners abandon intra-articular injections in favor of RF treatment.
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50

Candido, Kenneth D., Teresa M. Kusper, Bora Dinc, and Nebojsa Nick Knezevic. Epidural Blood Patch. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190271787.003.0036.

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Post-dural-puncture headache (PDPH) is a consequence of neuraxial anesthesia, diagnostic lumbar puncture, intrathecal drug delivery systems, or any other technique involving dural trespass. The spinal headache results from a dural puncture that leads to cerebrospinal fluid (CSF) leakage from the subarachnoid space to the epidural space, culminating in intracranial hypotension and development of a low-pressure headache. A key element of PDPH is an increase in pain severity upon a change in position from supine to upright, which corresponds to a gravity-induced influence on CSF pressure dynamics. Age, sex, and design of the needle used correlate with the risk of headache. Sometimes, the headache resolves spontaneously. At other times, conservative treatment or aggressive measures are required to terminate the pain. An autologous epidural blood patch is an established way preventing or treating PDPH. A careful history must be obtained to identify other causes of headache before the blood patch is attempted.
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