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Dissertations / Theses on the topic 'Spiral Diseases'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Suaide, André Luis Alarcon do Passo. "Desenvolvimento e validação de uma ferramenta computacional para mensuração das curvaturas da coluna vertebral." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/47/47135/tde-03042009-090940/.

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A coluna vertebral desempenha um papel importante no dia a dia oferecendo suporte necessário à movimentação do tronco além da locomoção do ser humano, sendo o seu funcionamento diretamente relacionado com a qualidade de vida; sua disposição e articulação das vértebras proporcionam estabilidade e flexibilidade à coluna vertebral, atributos necessários para o equilíbrio do ser humano. A hipercifose torácica, hiperlordose lombar e escoliose são as patologias posturais mais comuns e podem ser diagnosticadas pela mensuração do ângulo da curvatura da coluna vertebral. Comumente a radiografia é utili

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2

Vanhook, Patricia M., Lynne M. Dunphy, B. Porter, and C. Luskin. "Spinal Disorders." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7409.

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Book Summary: Serves the needs of advanced practice nurses because it’s written by nurse practitioners for nurse practitioners, in collaboration with a physician. Organizes content around the Circle of Caring framework for nursing-based knowledge and holistic care. Explores complementary and alternative treatments for each disorder. Covers the broadest range of human disease and disorders using a systems-based approach, presenting both common complaints and common problems to help students narrow down the possible differentials to the most likely diagnosis. Considers interactions of pharmace

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3

Hejmanowski, Ashley Quintin. "Allelic and genetic heterogeneity of two common genetic diseases." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1095309751.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xvi, 137 p.; also includes graphics (some col.). Includes bibliographical references (p. 127-137).

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4

Jee, Larry Donald. "The urological management of children with spinal dysraphism." Master's thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/25677.

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This project was undertaken with the following aims: 1) To generate a data base concerning the management of children with congenital spinal anomalies, who are known to form a significant proportion of the patients being treated in the Department of Paediatric Urology at Red Cross Hospital. 2) To assess the results of the management of these children, with special attention to the goals of therapy, namely preservation of renal function, establishment of urinary continence and protection from urinary tract infection. 3) To compare the treatment methods and results obtained to those repo

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5

Chan, Koon-ho, and 陳灌豪. "Clinical features, diagnosis and immunopathogenesis of neuromyelitis optica spectrum disorders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48521681.

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Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorders (CNS IDD) characterized by acute myelitis (AM) and optic neuritis (ON), especially clinically severe longitudinally extensive transverse myelitis (LETM) and simultaneous bilateral ON. Patients with recurrent AM especially LETM without ON, and patients with recurrent ON without AM may have disorders belonging to the spectrum of NMO, neuromyelitis optica spectrum disorders (NMOSD). NMO is likely autoimmune in nature as a significant proportion of patients are seropositive for aquaporin-4 (AQP4) autoantib

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6

Stephens, Benjamin. "Pathology of spinal interneurons in motor neuron disease." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251759.

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7

Mutsaers, Chantal. "Mechanisms of disease pathogenesis in Spinal Muscular Atrophy." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9774.

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Low levels of survival motor neuron (SMN) protein cause the autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA), through mechanisms that are poorly defined. SMN protein is ubiquitously expressed, however the major pathological hallmarks of SMA are focused on the neuromuscular system, including a loss of lower motor neurons in the ventral horn of the spinal cord and atrophy of skeletal muscle. At present there is no cure for SMA. Most research to date has focused on examining how low levels of SMN lead to pathological changes in motor neurons, therefore the contribution

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8

Deguise, Marc-Olivier. "Spinal Muscular Atrophy: Evidence of a Multi-System Disease." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40053.

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Spinal muscular atrophy (SMA) is a devastating recessive neurological disorder thought to be affecting primarily the motor neurons. As such, paralysis, motor weakness and death ensue. While SMA is most commonly seen in infants and children, it can span all ages. Its genetic etiology revolves around the homozygous deletion or mutation of the SMN1 gene, whose product (SMN protein) has critical and ubiquitous roles in mRNA splicing, amongst various other functions in mRNA metabolism. As such, SMN depletion in other non-neuronal cells type is likely to have physiological repercussions, and perhaps

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9

Laird, Angela S. Medical Sciences Faculty of Medicine UNSW. "Autonomic dysreflexia following high level spinal cord injury: time course, mechanisms and possible intervention." Awarded by:University of New South Wales. School of Medical Sciences, 2007. http://handle.unsw.edu.au/1959.4/31523.

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Following cervical or upper thoracic level spinal cord injury (SCI), motor, sensory and autonomic systems are disrupted. One form of this autonomic dysfunction is the condition autonomic dysreflexia (AD), which is characterised by episodes of high blood pressure in response to afferent input from regions below the injury level. An animal model of autonomic dysreflexia, the T4 transected rat, was used in this thesis to gain insight into the cardiovascular and temperature components of the disorder, possible peripheral mechanisms and interventions to prevent its development. Chapter 2 of the the

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10

Wahman, Kerstin. "Cardiovascular disease prevention after spinal cord injury : a new challenge /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-936-2/.

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11

Nelvagal, Hemanth Ramesh. "Spinal cord pathology in CLN1 disease : a novel therapeutic target." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/spinal-cord-pathology-in-cln1-disease(8b1dc3ed-dfd9-442d-a427-43ded0d82a6a).html.

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The neuronal ceroid lipofuscinoses (NCLs) are a group of up to 14 inherited progressive neurodegenerative lysosomal storage disorders affecting children and young adults. Together, they are the most common pediatric neurodegenerative storage disorders. Symptoms include loss of vision, epileptic seizures and the loss of cognitive and motor function. A lack of any effective therapies means that all forms are fatal. CLN1 disease or Infantile NCL is one of the most rapidly progressing forms of the disease and is caused by a deficiency of the lysosomal enzyme palmitoyl protein thioesterase – 1 (PPT

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12

Li, Ting-hung Darrell, and 李廷雄. "Ultrastructural imaging of the cervical spinal cord." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43572285.

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13

Chan, Ka-man, and 陳嘉雯. "Detection of anti-aquaporin (AQP4) autoantibodies in the diagnosis of neuromyelitis optica (NMO)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44659192.

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14

Rogers, A. T. "Spinal cord cell culture : a model for neuronal development and disease." Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234048.

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15

Noponen-Hietala, N. (Noora). "Spinal stenosis and intervertebral disc disease:the role of sequence variations in collagen IX and XI, and inflammatory factors in spinal disorders." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514277031.

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Abstract Genetic factors have been implicated to play a role in both degenerative lumbar spinal stenosis (LSS) and intervertebral disc disease (IDD). Sequence variations in the genes coding for collagen IX and inflammatory mediators have been indicated as risk factors for IDD. Nine genes coding for intervertebral disc (IVD) collagens I, II, IX and XI and aggrecan (AGC1) were analyzed for sequence variations in 29 Finnish individuals with LSS. In addition, two polymorphisms in the vitamin D receptor gene and one in the matrix metalloproteinase-3 gene were studied. Study subjects were analyzed

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16

Ruhno, Corey. "Identification of Modifiers of Spinal Muscular Atrophy." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1553525291539364.

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17

Lo, Yuk-fai, and 盧育輝. "Comparison between tissue-based indirect immunofluorescence andenzyme-linked immunosorbent assays, two detection methods for anti-aquaporin-4 antibodies in neuromyelitis optica spectrum disorders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46579266.

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18

Yaseen, Muhammad Usman. "Identification of cause of impairment in spiral drawings, using non-stationary feature extraction approach." Thesis, Högskolan Dalarna, Datateknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:du-6473.

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Parkinson’s disease is a clinical syndrome manifesting with slowness and instability. As it is a progressive disease with varying symptoms, repeated assessments are necessary to determine the outcome of treatment changes in the patient. In the recent past, a computer-based method was developed to rate impairment in spiral drawings. The downside of this method is that it cannot separate the bradykinetic and dyskinetic spiral drawings. This work intends to construct the computer method which can overcome this weakness by using the Hilbert-Huang Transform (HHT) of tangential velocity. The work is

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19

Aghanavesi, Somayeh. "Smartphone-based Parkinson’s disease symptom assessment." Licentiate thesis, Högskolan Dalarna, Mikrodataanalys, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:du-24925.

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This thesis consists of four research papers presenting a microdata analysis approach to assess and evaluate the Parkinson’s disease (PD) motor symptoms using smartphone-based systems. PD is a progressive neurological disorder that is characterized by motor symptoms. It is a complex disease that requires continuous monitoring and multidimensional symptom analysis. Both patients’ perception regarding common symptom and their motor function need to be related to the repeated and time-stamped assessment; with this, the full extent of patient’s condition could be revealed. The smartphone enables a

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20

Rademacher, Sebastian [Verfasser]. "Cytoskeletal dysregulation in the motoneuron disease Spinal Muscular Atrophy (SMA) / Sebastian Rademacher." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2017. http://d-nb.info/1136298002/34.

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21

Flank, Peter. "Spinal cord injuries in Sweden : studies on clinical follow-ups." Doctoral thesis, Umeå universitet, Rehabiliteringsmedicin, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125202.

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A spinal cord injury is a serious medical condition, often caused by a physical trauma. An injury to the spinal cord affects the neurotransmission between the brain and spinal cord segments below the level of injury. The SCI causes a loss of motor function, sensory function and autonomic regulation of the body, temporary or permanent. Significantly improved acute care, primary comprehensive rehabilitation and life-long structured follow-up has led to persons with spinal cord injury (SCI) living longer than ever before. However, increased long-time survival has allowed secondary conditions to e

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22

Amir, Nili S. "Frequency of Complications Following Spinal Fusion in Children with Cerebral Palsy." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1070.

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Background: Neuromuscular Scoliosis is a frequent complication of Cerebral Palsy that requires surgical management including spinal fusion. The objective of this observational study was to describe differences in the frequency of postoperative complications in children with Cerebral Palsy following spinal fusion surgery compared to children with Idiopathic Scoliosis. Methods: The 2016 Kids’ Inpatient Database was queried to identify pediatric patients (old) with concurrent diagnoses of Cerebral Palsy and Neuromuscular Scoliosis undergoing spinal fusion surgery. Cases were compared to children

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23

Nock, Bonnie J. (Bonnie Jean). "Echocardiographic Assessment of the Left Ventricle in the Spinal Cord Injured Patient." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc500420/.

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Ten caucasian male quadriplegics were compared with eight sedentary caucasian male controls in regards to left ventricular dimensions and mass obtained from echocardiograrns. The interventricular septum (IVS), left ventricular posterior wall (LVPW) and left ventricular internal diameter (LVII) were within normal limits for both groups. However, the INS in the SCI were significantly thicker than controls (p <0.05). Myocardial thickness was larger in SCI subjects (p <0.05). Absolute left ventricular mass (LVM) and total left ventricular volume was not different ( p > 0.05), but SCI subjects had

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24

Thomas, Patrick Shane. "The normal function of the androgen receptor plays a role in the pathology of SBMA /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5021.

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25

Davies, Diane Susan. "Effects of lifestyle risks on three major disease outcomes in spinal cord injured adults." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq22296.pdf.

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26

Consciência, José Alberto de Castro Guimarães. "Estabilização dinâmica em patologia degenerativa da coluna lombar: estado da arte e contributo pessoal." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2007. http://hdl.handle.net/10362/5204.

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Resumo Este trabalho encontra-se dividido em três capítulos distintos. No primeiro, é caracterizada a doença degenerativa lombar, demorando-se o autor na descrição pormenorizada das alterações anatómicas, biomecânicas, e bioquímicas inerentes à sua ocorrência. Segue-se a descrição da evolução das diferentes formas de terapêutica, enumerando as que de forma clássica mais frequentemente são utilizadas (cirúrgicas e não cirúrgicas). No segundo capítulo, são referidos os mais recentes avanços tecnológicos nesta área, mencionando, nas suas vertentes biomecânicas, clínicas e terapêuticas, as par

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27

Ichikawa, Shoji. "The molecular genetic analysis of three human neurological disorders." free online free to MU campus, others may purchase, 2002. http://wwwlib.umi.com/cr/mo/preview?3074409.

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28

El, Mendili Mohamed-Mounir. "Analysis of the structural integrity of the spinal cord in motor neuron diseases using a multi-parametric MRI approach." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066575/document.

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Les pathologies du motoneurone sont caractérisées par une atteinte progressive des motoneurones au niveau de la corne antérieur de la moelle épinière. Au delà de cette susceptibilité anatomique commune, qui est responsable d’une atteinte motrice progressive et diffuse dans ces pathologies, d’autres systèmes neurologiques sont touchés. La dégénérescence du faisceau corticospinal est une caractéristique classique dans la sclérose latérale amyotrophique, qui est la maladie du motoneurone la plus commune chez l’adulte. Cependant, il est de plus en plus reconnu que la SLA est une maladie multisysté

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Crowdus, Meyer Carolyn A. "Dietary Selenium Supplementation: Effects on Neurodegeneration Following Traumatic Brain and Spinal Cord Injury." UKnowledge, 2015. http://uknowledge.uky.edu/neurobio_etds/11.

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Traumatic brain and spinal cord injury continue to be substantial clinical problems with few available treatment strategies. Individuals who are at a greater risk for sustaining a central nervous system (CNS) injury, such as professional athletes and military personnel, may benefit from a prophylactic supplement that would intervene in the neurodegenerative pathways immediately following injury. The high demand for selenium within the central nervous system, as well as the synthesis of selenoproteins by neurons and astrocytes suggests a critical role of selenium within the brain and spinal cor

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Cortez-Bazán, Nathaly, Jennifer R. Delgado, Omar Galdos, and Luis Huicho. "Pott’s disease in upper thoracic vertebrae in atwo-year-old boy: Case report." Instituto Nacional de Salud, 2018. http://hdl.handle.net/10757/624633.

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Pott’s disease is a health problem in developing countries and its diagnosis in children is a challenge. Here we present the case of a two-year-old boy with Pott’s disease involving T1 to T3 thoracic vertebrae. The clinical presentation was characterized by difficulty walking, fever, cough, and dyspnea. At physical examination, kyphosis and bony prominence were observed in the cervicodorsal area. A positive tuberculin test was obtained, and Mycobacterium tuberculosis was isolated via culture of the gastric aspiration sample. The spine MRI showed a chronic abscess, destruction of two vertebrae,

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31

Cooper, Cindy L. "Neuropeptides, amines and amine receptors in the human spinal cord : the effects of Parkinson's disease." Thesis, University of Nottingham, 1989. http://eprints.nottingham.ac.uk/13218/.

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The aims of this study were to investigate (i) the levels of catecholamines, indoleamines, substance P and thyrotrophin-releasing hormone (TRH) in the post-mortem spinal cord of subjects who had died with Parkinson's disease and to compare them with those of control subjects (ii) adrenergic and serotonergic receptors in the post-mortem Parkinsonian and control spinal cord and (iii) the effects of subject age and sex and the interval between death and post-mortem (PMI) on the levels of neurotransmitters and neuropeptides and on receptor binding in post-mortem tissue. To perform these investigat

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Rivera, Victor. "HOW TRADITIONAL DEFINITIONS OF AUTONOMY IMPAIR DECISION-MAKING IN SPINAL MUSCULAR ATROPHY AND ALZHEIMER DISEASE." Master's thesis, Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/553526.

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Urban Bioethics<br>M.A.<br>Clinical decision making is influenced by available literature, technology, and guidelines, but also by cultural expectations, physician experience, and personal biases. The treatment of various forms of disability is especially vulnerable to these prejudices. Alzheimer Dementia (AD) and Spinal Muscular Atrophy (SMA) represent forms of cognitive and physical disability, respectively. In severe forms of both diseases, patients are often unable to communicate and do not meet traditional definitions of autonomy. However, physicians and consensus guidelines adhere to the

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Sleigh, James Nicholas. "Model systems for exploring new therapeutic interventions and disease mechanisms in spinal muscular atrophies (SMAs)." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:378416c5-a586-4a2a-980c-81dfff6803df.

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Spinal muscular atrophy (SMA) and Charcot-Marie-Tooth disease type 2D (CMT2D)/distal SMA type V (dSMAV) are two incurable neuromuscular disorders that predominantly manifest during childhood and adolescence. Both conditions are caused by mutations in widely and constitutively expressed genes that encode proteins with essential housekeeping functions, yet display specific lower motor neuron pathology. SMA results from recessive inactivating mutations in the survival motor neuron 1 (SMN1) gene, while CMT2D/dSMAV manifests due to dominant point mutations in the glycyl-tRNA synthetase (GlyRS) gene

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Paulson, Thomas A. W. "Supporting the prescription of exercise in spinal cord injured populations." Thesis, Loughborough University, 2013. https://dspace.lboro.ac.uk/2134/13454.

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Following a spinal cord injury (SCI), participation in regular exercise can enhance physical capacity and performance in activities of daily living. With this in mind, the use of subjective ratings of perceived exertion (RPE) may provide an easy-to-administer alternative to traditional methods of regulating exercise intensity (e.g. heart rate and power output (PO)). A physically active lifestyle is also associated with a reduced risk of cardiovascular disease, in part because exercise exerts anti-inflammatory effects. Examining the plasma response of inflammation-mediating chemical messengers,

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Jensen, Victoria N. "V2a neurons pattern respiratory muscle activity in health and disease." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1583155179498357.

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Bäumer, Dirk. "Functional genetic analysis of motor neuron disease." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:859016f8-5eff-4a8e-bfda-48afb8695646.

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Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the commonest motor neuron diseases of adult- and childhood onset. Alterations of the RNA binding protein TDP-43 are associated with most cases of ALS, while SMA is caused by deletion of the Survival Motor Neuron (SMN1) gene. SMN has been well characterised in its role in the assembly of the cellular machinery that carries out splicing of pre-mRNA, but is thought to have other functions in RNA metabolism unrelated to pre-mRNA splicing. It is conceivable that specific aspects of RNA handling are disrupted in both SMA and

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Pahuta, Markian. "Decision Analysis of Surgical Treatment Indications for Metastatic Epidural Spinal Cord Compression." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39390.

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Metastatic epidural spinal cord compression (MESCC) occurs when tumour invades the epidural space and compresses the spinal cord. Despite Level 1 evidence that surgery is the most effective treatment for MESCC, there is controversy regarding the role of surgery because of fear that patients who have a short survival will spend a large fraction of their remaining life recovering from surgery and potential complications. This controversy could be resolved by decision-analysis of MESCC treatments using quality-adjusted-life-years (QALYs). There have been two barriers to conducting decision-a

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Zbogar, Dominik. "Cardiovascular disease risk and central and peripheral responses to exercise in individuals with spinal cord injury." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/15888.

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Introduction: Persons with spinal cord injury (SCI) are often physically inactive and as such are at increased risk of cardiovascular morbidity. Fortunately, exercise training in SCI can provide improve health-related physical fitness and alleviate medical complications associated with deconditioning. To optimize health-related fitness gains of exercise in SCI and maximize the potential for chronic disease prevention it is necessary to understand the acute responses (central and peripheral) to exercise. Purposes: The primary purposes of this research were to: 1) determine the contribution of c

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39

Mulugeta, Ezra. "Muscarinic M₁ and M₄ receptor subtypes in normal and pathological conditions in the central nervous system : studies on human and animal tissues using subtype selective ligands /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-643-X/.

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40

Wasserman, Halley M. M. D. "Low bone mineral density and fractures are highly prevalent in pediatric patients with Spinal Muscular Atrophy regardless of disease severity." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1458299334.

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41

Bergen, Jamie M. "Understanding and overcoming the intracellular barriers associated with nonviral nucleic acid delivery to neurons /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/8040.

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42

Armstrong, Deborah K. "Transitioning Through Middle Age with an Incomplete Spinal Cord Injury: A Qualitative Description of Changes in Physical Function: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsn_diss/28.

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Over 260,000 Americans are living with a traumatic spinal cord injury (SCI). Medical advances have increased the longevity of individuals living with SCI into middle age and beyond. The majority of these individuals are living with an incomplete SCI (NSCISC, 2012), and the proportion of incomplete injuries is rising (DeVivo, 2012). There is little research that specifically examines the changes in physical function experienced by individuals aging with a traumatic incomplete SCI. The purpose of this qualitative descriptive study was to describe the changes in physical function experienced by p

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DiPeri, Timothy P. "Neuromodulation Therapy Mitigates Heart Failure Induced Hippocampal Damage." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/honors/208.

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Cardiovascular disease (CVD) is the leading cause of death in the United States. Nearly half of the people diagnosed with heart failure (HF) die within 5 years of diagnosis. Brain abnormalities secondary to CVD have been observed in many discrete regions, including the hippocampus. Nearly 25% of patients with CVD also have major depressive disorder (MDD), and hippocampal dysfunction is a characteristic of both diseases. In this study, the hippocampus and an area of the hippocampal formation, the dentate gyrus (DG), were studied in a canine model of HF. Using this canine HF model previously, we

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Jewett, Benjamin E. "Inverse Changes in Ghrelin and A2A Receptor Gene Expression Levels in the Hippocampus of Heart Failure Canines Following Spinal Cord Stimulation." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/honors/262.

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Myocardial infarction (MI), often referred to as a heart attack, is a serious health issue in the United States. There is a well-documented link between MI and major depressive disorder (MDD), with a high incidence of MDD occurring after an MI. Overlapping pathologies have been observed within the hippocampus of the brain in animal models of MI and depression. These observations suggest that pathobiological cross-talk between the heart and brain could have a role in the etiology of MDD that occurs after an MI. Spinal cord stimulation (SCS) has previously been shown to have both cardioprotectiv

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45

Erschbamer, Matthias. "Spinal cord injury : development of protection and repair strategies in rats /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-267-5/.

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46

Chiesa, Giulio. "Biophysical study of the aggregation of the androgen receptor protein in spinal bulbar muscular atrophy." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/400156.

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Spinal bulbar muscular atrophy (SBMA) is a member of the polyglutamine (polyQ) expansion diseases family; the most famous of which is Huntington disease (HD). SBMA is caused by the expansion of the coding region for the polyQ tract in the exon 1 of androgen receptor (AR), which represents the N-terminal intrinsically disordered transactivation domain (NTD). AR is the nuclear receptor sensible to testosterone and aggregates of this polyQ-expanded protein are observed in the motor neurons of SBMA patients. The aggregation mechanism of polyQ proteins depends both on the length of the tract

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Bose, Prodip Kumar. "Wobbler mouse : early detection of motoneuron disease, therapeutic evaluation of nutrition, neuropeptides & their antagonists, and the effects on neuronal sprouting in cervical spinal cord /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19118168.

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Hejmanowski, Ashley Q. "Allelic and genetic heterogeneity of two common genetic diseases." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1095309751.

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Naidoo, Marc Anton. "The risk for cardiovascular disease following traumatic spinal cord injuries in the Cape Metropolitan in South Africa." University of the Western Cape, 2018. http://hdl.handle.net/11394/6885.

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Abstract:

Philosophiae Doctor - PhD<br>Given the devastating and debilitating impact of spinal cord injuries (SCI) globally and the effects on any population, its impact extends far beyond just the victim to people and institutions surrounding them and supporting them post-injury. Of growing concern is the increased risk that individuals with SCI have been seen to have a three-fold greater risk of developing cardio-vascular disease (CVD) than their able-bodied counterparts. Prevention strategies to curtail the onset of CVD in the SCI population is limited, and often developed for individuals from develo

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Jones, Page. "Enzymatic and proteomic analysis of spinal cord in a G93A ALS mouse model." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008r/jonesp.pdf.

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