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Dissertations / Theses on the topic 'Spirocycles'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 January 2025

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1

Powell, Nicola Helen. "Novel oxetane-containing spirocycles and peptidomimetics." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/66720/.

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This thesis describes work focused on the use of oxetane rings as isosteres and incorporation of this functional group into pharmaceutically relevant scaffolds. Chapter 1 describes work directed towards the synthesis of 1,5-dioxaspiro[2.3]hexanes via three different strategies, namely ring-closure to form the oxetane ring, Corey epoxidation of the corresponding 3-oxetanones, and epoxidation of the corresponding 3-methylene oxetane. Nucleophilic ring-opening of substituted 1,5-dioxaspiro[2.3]hexanes to give amino acid type isosteres is also investigated. Chapter 2 details the synthesis of novel
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2

Lombard, Fanny Julie Amandine. "The Synthesis of Spirocycles via C–H Insertion." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367715.

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This thesis describes the design and development of a new methodology for the synthesis of spiroacetals involving a rhodium(II)-catalysed C–H insertion of suitable diazo precur- sors. Three generations of diazo precursors were designed, synthesised and treated with Rh(II) catalysts: The 1st generation precursor consisted of a phenyl substituted tetrahydropyranyl acetal bearing a proximal phenyl diazoketone substituent, which underwent Rh(II)-catalysed C– H insertion to give unexpected spirocyclic orthoesters. DFT calculations showed that these ’anomalous’ products are formed by a mechanism inv
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3

Main, Calver A. "Novel titanium carbenoid reagents : diversity orientated synthesis of indoles and spirocycles." Thesis, University of Glasgow, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502007.

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A new synthetic strategy for the preparation of a 96-member library of 2,5-disubstituted indoles involving traceless cleavage from resin is presented. A boronate-bearing titanium alkylidene was prepared and used to convert 8 resin-bound esters into immobilised enol ethers. Cleavage from resin in mild acid with concomitant cyclisation yielded boronate-bearing indoles. Capitalising on the immobilised boronate functionality in enol ethers, Suzuki cross-coupling reactions were performed with 12 aryl iodides to give a 96-member library after cleavage from resin with mild acid, 79 members of the lib
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4

Schoenn, Guillaume. "Stratégies de synthèse de sesquiterpènes quinones/hydroquinones : synthèse totale de la dactyloquinone A et de la structure proposée de la spiroetherone A." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF089.

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La dysiarenone est un méroterpénoïde pseudo-dimérique, présentant un squelette 2-oxaspiro[bicyclo[3.3.1]nonane-9,1′-cyclopentane] inédit, isolé à partir de l'éponge marine Dysidea arenaria. Les septosones B et C partagent un motif rare de type spiro[4.5]décane. On observe une importante similarité entre les septosones B et C et l'un des pseudo-monomères de la dysiarenone. Le second pseudo-monomère nécessaire à la dimérisation est l'avarone, une quinone/hydroquinone sesquiterpénique bien connue de la littérature. L'objectif principal de cette thèse était de synthétiser le précurseur spirocycliq
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5

Deslandes, Maria. "SYNTHESIS OF ALL-CARBON SPIROCYCLES BY INTRAMOLECULAR IRON-MEDIATED DIENE/OLEFIN CYCLOCOUPLING." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1354141980.

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6

Soklou, Kossi Efouako. "Synthèse d'hétérospirocycles par hydroaminations et hydroalkoxylations d'alcynes catalysées par l'or (I) - Méthodologie et application au développement de fragments spirocycliques pour la chimie médicinale." Thesis, Orléans, 2020. http://www.theses.fr/2020ORLE3066.

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Synthétiser des molécules azotées ou oxygénées spiro [4.5] ou spiro [5.5] possédant une liaison entre le carbone spiranique et l’atome d’azote ou d’oxygène reste un défi même si ces fragments sont représentés dans la nature et dans l’arsenal thérapeutique. Pour lever cette contrainte, nous avons développé une méthode générale de spirocyclisation catalysée par l’or (I) passant par des réactions d’hydroamination ou d’hydroalkoxylation d’alcynes. Dans la première partie de cette thèse, nous avons pu optimiser les conditions de spirocyclisation à base de JohnPhosAu(CH3CN)SbF6 en série azotée et ox
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7

Hilmey, David George. "Synthesis and study of heteroatomic spirocyclic scaffolds." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1141334542.

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8

Nocquet, Pierre-Antoine. "Vers la synthèse d'une nouvelle classe d'iminosucres conformationnellement contraints : ouverture d'azétidines, cyclisation 4-exo-trig et C-H amination catalytique." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAF047/document.

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De précédentes études dans notre groupe ont montré que l'α-1-C-nonyl-1,5-didésoxy-1,5-imino-D-xylitol était un inhibiteur puissant de la β-glucocérébrosidase, enzyme impliquée dans la maladie de Gaucher. Il a été supposé que la conformation chaise inversée de ce composé pouvait expliquer en partie sa forte affinité avec la glycosidase cible. L'objectif ce travail de thèse était la synthèse d'une nouvelle classe d’iminosucres, basée sur un squelette 1-azaspiro[3.3]heptane, possédant deux cycles à 4 membres, analogue conformationnellement contraint de notre "lead" en série iminoxylitol. La premi
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9

Magne, Fanny. "Synthèse d’hétérocycles spiraniques à visée thérapeutique." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2046/document.

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Depuis quelques années, l’élaboration de molécules spiraniques connait un essor considérable avec, en particulier, comme but essentiel l’accroissement de la diversité moléculaire considérée à ce jour comme insuffisamment développée. L’objectif de cette thèse de doctorat a été la synthèse de nouvelles entités tricycliques arylaliphatiques possédant un carbone spiranique et ce, en complément des travaux antérieurement effectués au laboratoire. Dans un premier temps, nous avons choisi de générer des molécules regroupant des structures de type indane-1,2’-(azétidine, pyrrolidine et pipéridine). La
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10

Hensienne, Raphaël. "Nouvelles classes d’iminosucres bicycliques : approche synthétique des squelettes 5-azaspiro[3.4]octane et 6-azabicyclo[3.2.0]heptane." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF049/document.

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Des études antérieures conduites par notre groupe ont permis d’identifier l’α-1-C-nonyl-1,5-didésoxy-1,5-imino-D-xylitol en tant que puissant inhibiteur de la β-glucocérébrosidase – enzyme impliquée dans la maladie de Gaucher. La conformation inhabituelle (chaise inversée) de ce composé nous a incités à étudier plus avant la relation entre conformation et activité biologique des iminosucres. L’objectif de ces travaux de thèse consistait ainsi en la synthèse d’analogues conformationnellement contraints d’iminosucres. Dans un premier temps, trois spiro-iminosucres basés sur un squelette 5-azaspi
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11

Bouhlel, Ahlem. "Cyclisations radicalaires oxydatives médiées par l'acétate de manganèse (III) et orientées vers la chimie médicinale." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5501/document.

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Ce travail s'inscrit dans la recherche et le développement de nouvelles molécules à visée thérapeutique via la mise au point de cyclisations radicalaires oxydatives médiées par l'acétate de manganèse(III). Deux problématiques ont dirigé nos recherches. Tout d'abord, nous avons développé une stratégie de synthèse de prodrogues analogues de la pafuramidine, molécule antileishmanienne. Ainsi, une 1ère série d'amidoximes a été obtenue à partir de β-cétosulfones par une synthèse multi-étapes faisant appel aux réactions i) de cyclisations radicalaires oxydatives médiées par Mn(OAc)3 et ii) de c
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12

Kern, Nicolas. "Réactivité d'azacycles en catalyse à l'or." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF012/document.

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La catalyse organométallique est l'un des piliers de la synthèse chimique moderne. Elle permet notamment la formation rapide de liaisons carbone-carbone et carbone-hétéroatome, processus les plus importants pour la fabrication des milliers de composés nécessaires à la vie contemporaine. Elle répond également aux critères d'économie d'atomes et d'énergie, et de réduction des déchets, des risques et des coûts de mise en oeuvre d'une réaction chimique.Parmi les thématiques les plus récentes de la synthèse organique, la catalyse homogène à l'or s'est imposée en seulement quelques années comme un o
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13

Ferrari, Frank D. "Flexible synthesis of spirocyclic pyrans and piperidines." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3829/.

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Spirocyclic piperidines and spirocyclic pyrans are prevalent throughout nature, often appearing in natural products which exhibit exciting biological activities. Notable examples of spirocyclic piperidine-containing biologically active natural products are halichlorine, pinnaic acid and tauropinnaic acid. Despite their structural similarity, halichlorine and the pinnaic acids were isolated from separate organisms; halichlorine was isolated from extracts of the marine sponge Halichondria okadai while both pinnaic acid and tauropinnaic acid were isolated from the Okinawan bivalve mollusc Pinna m
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14

Prail, J. "The synthesis and biohydroxylation of spirocyclic amides." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293090.

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15

Pancholi, Alpa Kishor. "Synthesis of substituted azetidines and spirocyclic diazetidines." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/102606/.

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Chapter 1 begins with an introduction to azetidines, including a discussion of the methodologies for their synthesis, their applications, relevance in natural products and as building blocks in medicinal chemistry. It then describes the development of a new asymmetric route to 2-substituted azetidin-3-ones using Enders’ SAMP/RAMP auxiliary. A one-pot process was developed involving the metalation of SAMP hydrazones of N-Boc-azetidin-3-one, alkylation and subsequent in situ hydrolysis to give the substituted products. Various bases and reaction conditions were explored to find optimal condition
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16

Branan, Bruce Monroe. "The chemistry of polycyclic and spirocyclic compounds /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487849696968107.

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17

Bird, P. M. "Stereocontrol in the synthesis of substituted spirocyclic ethers." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596658.

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This thesis describes the synthesis of spirocyclic ethers with substituents in both rings. The strategy employed is considered in stepwise manner starting with the two-step synthesis of the substituted cyclic α-phenylsulfanylcarbaldehydes A and B from the corresponding cyclic ketones, paying particular attention to the stereoselectivity in the first step and the stereospecificity of the second. Simple aldol reactions of these aldehydes with ester and ketone enolates are reported, along with the conversion of the aldol products C to (1,3)-diols D by reduction (including the[1,3]-stereoselective
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18

Bouhlel, Ahlem. "Cyclisations radicalaires oxydatives médiées par l'acétate de manganèse (III) et orientées vers la chimie médicinale." Electronic Thesis or Diss., Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5501.

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Ce travail s'inscrit dans la recherche et le développement de nouvelles molécules à visée thérapeutique via la mise au point de cyclisations radicalaires oxydatives médiées par l'acétate de manganèse(III). Deux problématiques ont dirigé nos recherches. Tout d'abord, nous avons développé une stratégie de synthèse de prodrogues analogues de la pafuramidine, molécule antileishmanienne. Ainsi, une 1ère série d'amidoximes a été obtenue à partir de β-cétosulfones par une synthèse multi-étapes faisant appel aux réactions i) de cyclisations radicalaires oxydatives médiées par Mn(OAc)3 et ii) de c
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19

Mackay, C. "Spirocyclic intermediates in the electrophilic ring closures of heterocycles." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233067.

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20

Saruengkhanphasit, Rungroj. "Synthesis of spirocyclic amines by dipolar cycoaddition of nitrones." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/17073/.

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21

Harnor, Suzannah Jane. "Studies towards the synthesis of LL-Z1640-2 and spirocyclic systems." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2016/.

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Resorcyclic acid lactones (RALs) are natural products, with some having been shown to be potent inhibitors of several protein kinases and mammalian cell proliferation and tumour growth in animals. LL-Z1640-2 (also known as 5Z-7-oxo-zeanol or C292) is a cis-enone RAL, isolated in 1978 from fungal broth and classified as an anti-protozoal agent. Later, in 1999, its cytokine releasing inhibiting activity was discovered, with subsequent data showing it could selectively and irreversibly inhibit transforming growth factor activating kinase-1 (TAK1) activity at low concentrations. It is also reporte
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22

Maurya, S. K. "Divergent synthesis of spirocyclic small molecules and synthetic studies on crassifosides." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2007. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2597.

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23

Dong, Shuzhi. "I. Restriction of DNA conformation by spirocyclic annulation at C-4'. II. Studies toward the enantioselective synthesis of pestalotiopsin A." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1174627553.

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24

Ferdenzi, Antoine. "Approche des synthèses de la saraïne A et de la misénine, alcaloïdes marins extraits de l'éponge reniera saraï, à partir d'une hypothèse biogénétique commune." Paris 11, 2006. http://www.theses.fr/2006PA112242.

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25

Hussain, Fazal. "The cyclisation of benzylaminoacetonitriles : evidence of exclusive participation of a spirocyclic intermediate." Thesis, University of Bath, 1985. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354728.

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A survey has been made of isoquinoline preparation via Pomeranz-Fritsch and benzylaminoacetonitrile syntheses. Over the past fifteen years considerable effort has been made to establish the mechanism by which cyclisations of 3,4-dialkoxybenzylaminonitriles proceeds. Initially a dual mechanism was postulated, one mode involving an electrophilic attack para to the C3-substituent and the second involving attack para to the C4-substituent. Recent evidence from the cyclisations of the isomeric ethoxymethoxybenzylaminoacetonitriles suggested that only the second mechanism may be operating, giving a
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26

Peneau, Augustin. "Vers la synthèse totale du 13-desméthyle spirolide C. Synthèse d’hétérocycles par activation C–H catalysée au Rh(III)." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS410/document.

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Certaines phycotoxines marines de la famille des spiroimines, comme la gymnodimine et les spirolides sont produites par des dinoflagellés et se concentrent dans les mollusques filtreurs. Puis, par transport vectoriel, elles peuvent atteindre les animaux marins et les êtres humains. Des études biologiques ont montré que ces toxines sont de puissants antagonistes des récepteurs nicotiniques de l’acétylcholine (nAChRs) et qu’elles présentent une spécificité modérée pour des sous-types de récepteurs. Au laboratoire, nous nous intéressons à la synthèse totale du 13-desméthyle spirolide C, dans le b
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27

Kahane, Alexandra L. "Restriction of DNA conformation by spirocyclic annulation at C4': synthesis of the nucleoside building blocks." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1072903762.

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28

Kahane, Alexandra Lyn. "Restriction of DNA conformation by spirocyclic annulation at C4' synthesis of the nucleoside building blocks /." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1085083063.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xxii, 204 p.; also includes graphics Includes bibliographical references (p. 114-127). Available online via OhioLINK's ETD Center
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29

Dushing, M. P. "“Target cum flexibility": towards the synthesis of spirocyclic nucleosides, carbapenems and tri-/tetracyclic tetrahydroisoquinoline alkaloids." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2013. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2205.

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30

Kujawa, Szymon. "Rapid generation of molecular complexity under Pd(II) and Rh(III) catalysis." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/11697.

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1. Enantioselective Pd(II)-Catalysed Nucleophilic Additions of 2- Alkylazaarenes The first project deals with enantio- and diastereoselective palladium(II)-catalysed nucleophilic additions of 2-alkylazaarenes to N-Boc imines and nitroalkenes. Under the optimised reaction conditions high levels of diastereo- and enantioselection of the addition products were achieved. Introduction of the electron-withdrawing group at the aryl ring of the substrate allows running the reaction under mild, experimentally convenient reaction conditions. The new described method allows the enantioselective synthesis
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31

Prusov, Evgeny. "Synthesis of spirocyclic scaffolds by aminoallylation/RCM sequence and approach toward the total synthesis of the Macrolide Dictyostatin." [S.l. : s.n.], 2008.

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32

Nazeruddin, G. M. "Photochemical studies of α-substituted propiophenones and construction of bicyclo [m.3.0] bridged alkenes: thermal rearrangement of spirocyclic vinylcyclopropanes". Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1995. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2806.

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33

Dong, Shuzhi Dong Shuzhi. "I. Restriction of DNA conformation by spirocyclic annulation at C-4' II. Studies toward the enantioselective synthesis of pestalotiopsin A /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1174627553.

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34

Odelius, Karin. "Design of polyester and porous scaffolds." Licentiate thesis, Stockholm, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-493.

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35

Afewerki, Samson. "Development of catalytic enantioselective C-C bond-forming and cascade transformations by merging homogeneous or heterogeneous transition metal catalysis with asymmetric aminocatalysis." Doctoral thesis, Mittuniversitetet, Avdelningen för naturvetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-23605.

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Chiral molecules play a central role in our daily life and in nature, for instance the different enantiomers or diastereomers of a chiral molecule may show completely different biological activity. For this reason, it is a vital goal for synthetic chemists to design selective and efficient methodologies that allow the synthesis of the desired enantiomer. In this context, it is highly important that the concept of green chemistry is considered while designing new approaches that eventually will provide more environmental and sustainable chemical synthesis.The aim of this thesis is to develop th
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36

Hartung, Ryan Eugene. "I. Synthesis of saturated, DNA, and RNA spirocyclic-4,4-nonane nucleosides. II. Studies toward epoxy carbonate formation and the synthesis of suitable precursors III. Methodological investigations involving the reactions of diazomethane with di-, tri-, an." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1130940224.

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37

Ondet, Pierrick. "Synthèse d'éthers polycycliques par cycloisomérisations catalysées par des acides de Lewis : applications dans le domaine des arômes et parfums." Thesis, Université Côte d'Azur (ComUE), 2016. http://www.theses.fr/2016AZUR4075/document.

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Les molécules polycycliques, et notamment les éthers spirocycliques, sont des structures présentant un fort intérêt dans le domaine de la chimie des parfums. Cette thèse est dédiée au développement de nouvelles cycloisomérisations de dérivés d’éthers d’énol catalysées par le triflate de bismuth(III). Une étude bibliographique a ainsi été consacrée aux réactions de cyclisation catalysées par Bi(OTf)3. Une réaction de cycloisomérisation d’éthers d’énol alléniques permettant la formation rapide de produits cyclopenténiques et dihydrofuraniques a été développée. Des dérivés oxaspirocycliques ont é
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Kitschke, Philipp. "Experimental and theoretical studies on germanium-containing precursors for twin polymerization." Doctoral thesis, Universitätsbibliothek Chemnitz, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-205443.

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Im Fokus dieser Arbeit standen zwei Ziele. Zum einem war es Forschungsgegenstand, dass Konzept der Zwillingspolymerisation auf germaniumhaltige, molekulare Vorstufen wie zum Beispiel Germylene, spirozyklische Germaniumverbindungen und molekulare Germanate zu erweitern und somit organisch-anorganische Komposite beziehungsweise Hybridmaterialien darzustellen. Dazu wurden neuartige Germaniumalkoxide auf der Basis von Benzylalkoholaten, Salicylalkoholaten sowie Benzylthiolaten synthetisiert, charakterisiert und auf ihre Fähigkeit Komposite beziehungsweise Hybridmaterialien über den Prozess der Zwi
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Finne, Anna. "Novel Possibilities for Advanced Molecular Structure Design for Polymers and Networks." Doctoral thesis, KTH, Polymerteknologi, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3623.

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Synthetic and degradable polymers are an attractive choicein many areas, since it is possible to control the way in whichthey are manufactured; more specifically, pathways tomanipulate the architecture, the mechanical properties and thedegradation times have been identified. In this work,L-lactide, 1,5-dioxepan-2-one and ε-caprolactone were usedas monomers to synthesize polymers with different architecturesby ring-opening polymerization. By using novel initiators,triblock copolymers, functionalized linear macromonomers andstar-shaped aliphatic polyesters with well-defined structureshave been s
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Hartung, Ryan E. "I. Synthesis of saturated, DNA, and RNA spirocyclic-4,4-Nonane nucleosides. II. Studies toward epoxy carbonate formation and the synthesis of suitable precursors III. Methodological investigations involving the reactions of diazomethane with di-, tri-, and tetraketones. IV. Towards the total synthesis of salicifoline." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1130940224.

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Gilles, Laure. "Découverte et synthèse chimique d'odorants par des technologies innovantes." Electronic Thesis or Diss., Université Côte d'Azur, 2022. http://www.theses.fr/2022COAZ4100.

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Les contraintes réglementaires des autorités nationales et internationales et les exigences des consommateurs de plus en plus importantes, ainsi que la quête de nouvelles compositions originales, incitent l'industrie de la parfumerie à être constamment à la recherche de nouvelles molécules organoleptiques sûres, durables et innovantes. À cet égard, grâce à la grande diversité du règne végétal, les substances naturelles complexes (SNC), sont une source riche d'ingrédients. Elles sont également une source d'inspiration pour les chimistes, qui peuvent utiliser la synthèse pour avoir un accès cont
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Amireddy, Mamatha, and 馬瑪塔. "Organocascade Synthesis of Functionalized Spirocycles and Bicycles." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/89143368048146984050.

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博士<br>國立臺灣師範大學<br>化學系<br>105<br>The content of this thesis is divided into three chapters. The chapter-I, illustrate overview on asymmetric synthesis and organocatalysis. It includes, terminology, introduction to asymmetric synthesis, some historical aspects of organocatalysts, classification and utilization of covalent catalysis including iminium and enamine, non-covalent catalysis including phase-transfer catalysts, hydrogen bonding catalysts and importance of alkaloids in asymmetric synthesis as organocatalysts. And successful applications on important C-C bond forming asymmetric Michael do
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Fleury, Melissa. "Ring expansion reactions to form spirocycles and its application to the synthesis of cylindricine B." Thesis, 2003. http://hdl.handle.net/2429/14361.

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The photochemically initiated semipinacol rearrangement of a substrate bearing an intramolecular alcohol 1.10 was attempted in order to provide spirocyclic ring systems. The syntheses of carbocyclic ring expansion precursors were achieved. Unfortunately, the use of U V light and a photosensitizer to initiate ring expansion reaction was unsuccessful. It was found that a majority of siloxy-epoxide ring expansions of cyclobutane rings to form l-azaspiro[5.4]decanes are unselective. The ring expansion of cyclobutane rings was executed on siloxy-epoxide carbocycles 2.6 and 2.15 and heterocycl
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Lejkowski, Michal [Verfasser]. "Asymmetric synthesis of medium-sized carbocycles, spirocycles and oxabicycles via ring closing metathesis of sulfoximine substituted trienes and dihydropyran derivatives / vorgelegt von Michal Lejkowski." 2008. http://d-nb.info/992062527/34.

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Savage, Nikolas Alexander. "Accessing fused and spirocyclic ring formations via carbon - carbon bond activation." Thesis, 2013. http://hdl.handle.net/2152/23647.

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Carbon-carbon bonds are ubiquitous in synthetic chemistry and constitute the skeletal backbone of a significant number of compounds. Utilizing transition metal mediated catalysis, a wide array of fused and spirocyclic ring systems containing diverse functionalization were accessed. These investigations provide unique ways to prepare carbon frameworks that are otherwise nontrivial to construct using classical approaches. The derivatives were rapidly accessed through optimized methods.<br>text
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46

McKenzie, Jean Mary-Anne. "Application of the Noyori annulation reaction to the cephalotaxine spirocycle." Thesis, 2001. http://hdl.handle.net/10413/3008.

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Cephalotaxine is a naturally occurring alkaloid which is the structural motif of a number of compounds which have shown promising anti-cancer properties. This fact together with its relatively complex pentacyclic structure, which incorporates an azaspirocycle annular to a benzazepine moiety, has resulted in its popularity as a synthetic target. The aim of this project was to synthesise the azaspirocycle of cephalotaxine using a Noyori annulation method involving the reaction of an enamine and an a,a' -dibromo ketone in the presence of Fe2{CO)9. In the first attempt the reaction of l-benzyl-2-m
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Nigríni, Martin. "Enantioselektivní syntéza bispirosloučenin." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-436011.

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This diploma thesis is focused on synthesis of enantiomeric and diastereomeric pure bispirocyclic compounds via sequential Mannich/hydroamination reaction. The first part is focused on the optimization of reaction conditions of enantioselective asymmetric organocatalytic Mannich reaction of pyrazolone derivatives with isatin-derived ketimines. The enantiomerically enriched Mannich adducts were used in hydroamination cyclization. The second part of the work is focused on finding the suitable reaction conditions for performing the Mannich reaction and hydroamination as a sequential reaction lead
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Chaudhari, Prakash Dilip. "Development of One-Pot Organocatalytic Enantioselective Reactions for the Synthesis of Polysubstituted Spirocyclic Oxindole Derivatives and Spirocyclopentane Oxindoles." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/6z2y5u.

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博士<br>國立中正大學<br>化學暨生物化學研究所<br>107<br>This dissertation demonstrates our innovation in the area of asymmetric amino as well as hydrogen-bonding catalysis for the synthesis of enantioenriched polycyclic spirooxindole compounds. In the second chapter, we have discussed the novel organocatalytic quadruple organocascade Michael-Michael-Michael-aldol condensation reaction between (E)-1- methyl-3-(3-nitroallyl)indolin-2-one 34 and two molecules of α,β−unsaturated aldehydes 35 via consecutive iminium-enamine-iminium-enamine catalysis for the formation of highly functionalized polysubstituted spirooxin
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UN, PUI-WAI, and 阮沛慧. "Construction of spirocyclic 1,4-diones via the N-heterocyclic carbene/urea cocatalyzed intramolecular Stetter reaction of cyclic enone-aldehydes." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/9afgzq.

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碩士<br>國立中正大學<br>化學暨生物化學研究所<br>107<br>In this thesis we have studied N-heterocyclic carbene (NHC) and urea cocatalyzed intramolecular Stetter reaction of the cyclic enone- aldehydes to construct spiro compounds. Treatment of the cyclic enones tether with 4-oxobutyl side chain with NHC and urea in toluene at room tempurature obtained the desired spiro[4.m]decane-1,7-diones in 27-81% yields. In the cases of the methylcyclohexenones tether with 4-oxobutyl afforded spiro[4.m]decane-1,7-diones along with benzoin products. However, gem-dimethylcyclohexenones tether with 4-oxobutyl only produced the b
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Vidulova, Daniela Boneva. "Studies toward the synthesis of EFGH ring system diazonamide A Pummerer chemistry applied toward the synthesis of 3,3-spirocyclic oxindoles." 2005. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-746/index.html.

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