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Journal articles on the topic 'Spongy Tissue Disorder'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Oak, Pranjali, Ashish Deshpande, Ashok Giri, and Vidya Gupta. "Metabolomic Dynamics Reveals Oxidative Stress in Spongy Tissue Disorder During Ripening of Mangifera indica L. Fruit." Metabolites 9, no. 11 (2019): 255. http://dx.doi.org/10.3390/metabo9110255.

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Spongy tissue disorder, a mesocarp specific malady, severely affects the flavor and pulp characters of Alphonso mango fruit reducing its consumer acceptability. Here, we investigated comparative metabolomic changes that occur during ripening in healthy and spongy tissue-affected fruits using high resolution mass spectrometric analysis. During the spongy tissue formation, 46 metabolites were identified to be differentially accumulated. These putative metabolites belong to various primary and secondary metabolic pathways potentially involved in maintaining the quality of the fruit. Analysis reve

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2

Balaji K. Dudhate and Dhondiram P. Gadgile. "Study of Spongy Tissue Incidence in Mango (Mangifera Indica L.) Varieties in Parbhani District of Maharashtra, India." International Journal of Latest Technology in Engineering Management & Applied Science 14, no. 5 (2025): 729–31. https://doi.org/10.51583/ijltemas.2025.140500078.

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Abstract: Several mango varieties, including local ones, were collected from the different vendors in the Parbhani fruit market and studied to measure the incidence of spongy tissue disorder. Incidence was measured using a disease incidence formula. Among these, Alphonso, Badam, Kesar, Parbhani Hapus, and Local mango fruits showed spongy incidence. It was observed that the incidence of spongy tissue in different varieties sampled was contrasting. The highest incidence was found in Alphonso fruits, whereas the lowest was found in Kesar fruits.

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Oak, Pranjali S., Ashish B. Deshpande, Keshav H. Pujari, Shrikant S. Prabhudesai, Ashok P. Giri, and Vidya S. Gupta. "Data on metabolic profiling of spongy tissue disorder in Mangifera indica cv. Alphonso." Data in Brief 22 (February 2019): 145–57. http://dx.doi.org/10.1016/j.dib.2018.11.140.

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4

Chen, Weifeng, Dan Tang, Jia Huang, Yu Yang, and Liangbo Zhang. "Microbial Community Structure and Metabolic Potential Shape Soil-Mediated Resistance Against Fruit Flesh Spongy Tissue Disorder of Peach." Agronomy 15, no. 7 (2025): 1697. https://doi.org/10.3390/agronomy15071697.

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Peach fruit flesh spongy tissue disorder causes dry, porous, and brown areas in the flesh, severely compromising fruit quality and market value. While soil properties and calcium nutrition have been linked to the disorder, the role of rhizosphere microbial communities in disorder resistance remains unclear. This study investigated both the physicochemical properties and the root-associated microbiomes of disordered (CK) and healthy (TT) peach orchards to explore microbial mechanisms underlying disorder suppression. TT soils exhibited higher pH, greater organic matter, increased exchangeable ca

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da Silva Alves, Jasciane, Bruna Parente de Carvalho Pires, Luana Ferreira dos Santos, et al. "Non-Destructive Detection of Current Internal Disorders and Prediction of Future Appearance in Mango Fruit Using Portable Vis-NIR Spectroscopy." Horticulturae 11, no. 7 (2025): 759. https://doi.org/10.3390/horticulturae11070759.

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A method based on Vis-NIR spectroscopy and machine learning-based modeling for non-destructive detection of the internal disorders of black flesh, spongy tissue, jelly seed, and soft nose in mango fruit was developed using the vis-NIR spectra of intact mango fruit of three cultivars sourced from three orchards in each of the two seasons, with spectra collected both at harvest and after storage. After spectra were acquired of the stored fruit, the fruit cheeks were cut longitudinally to allow visual assessment of the incidence of the internal disorders. Five models were evaluated: two tree-base

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de Oliveira Lima, L. C., A. B. Chitarra, M. I. F. Chitarra, and E. B. Silva. "ENZYMATIC ACTIVITY CHANGES IN SPONGY TISSUE: A PHYSIOLOGICAL RIPENING DISORDER OF âTOMMY ATKINSâ MANGO." Acta Horticulturae, no. 485 (March 1999): 255–58. http://dx.doi.org/10.17660/actahortic.1999.485.35.

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7

Janave, Machhindra T. "Profile of peroxidase isoforms influenced by spongy tissue disorder in Alphonso mango (Mangifera indica L.) fruits." Acta Physiologiae Plantarum 31, no. 6 (2009): 1175–84. http://dx.doi.org/10.1007/s11738-009-0337-9.

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8

Thomas, P., S. C. Saxena, R. Chandra, R. Rao, and C. R. Bhatia. "X-ray imaging for detecting spongy tissue, an internal disorder in fruits of ‘Alphonso’ mango (Mangifera indicaL.)." Journal of Horticultural Science 68, no. 5 (1993): 803–6. http://dx.doi.org/10.1080/00221589.1993.11516416.

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9

Bailey, Douglas A., and P. Allen Hammer. "Stimulation of “Hydrangea Distortion” Through Environmental Manipulations." Journal of the American Society for Horticultural Science 114, no. 3 (1989): 411–16. http://dx.doi.org/10.21273/jashs.114.3.411.

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Abstract Plants of Hydrangea macrophylla Thunb. were grown in various environments to identify factors responsible for the appearance of malformed hydrangea leaves and to screen cultivars for tolerance to the foliar disorder. Ambient temperature, photosynthetic photon flux (PPF), and root system temperature were studied. Hydrangea leaf malformation is under thermal control and can be stimulated by ambient temperatures of 33/26C (light/dark), but these must be maintained to sustain the development of distorted foliage. Placement of plants with malformed leaves into a 26/22C (light/dark) environ

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10

Trivedi, Mahendra Kumar, Alice Branton, Dahryn Trivedi, Gopal Nayak, Sambhu Charan Mondal, and Snehasis Jana. "Morphological Characterization, Quality, Yield and DNA Fingerprinting of Biofield Energy Treated Alphonso Mango (Mangifera indica L.)." Journal of Food and Nutrition Sciences 3, no. 6 (2015): 245–50. https://doi.org/10.11648/j.jfns.20150306.18.

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Alphonso is the most delicious variety of mango (Mangifera indica L.) known for its excellent texture, taste, and richness with vitamins and minerals. The present study was attempted to evaluate the impact of Mr. Trivedi’s biofield energy treatment on morphological characteristics, quality, yield and molecular assessment of mango. A plot of 16 acres lands used for this study with already grown mango trees. This plot was divided into two parts. One part was considered as control, while another part was subjected to Mr. Trivedi’s biofield energy treatment without physically touching

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Trivedi, Mahendra Kumar, Alice Branton, Dahryn Trivedi, Gopal Nayak, Sambhu Charan Mondal, and Snehasis Jana. "Morphological Characterization, Quality, Yield and DNA Fingerprinting of Biofield Energy Treated Alphonso Mango (Mangifera indica L.)." Journal of Food and Nutrition Sciences 3, no. 6 (2015): 245–50. https://doi.org/10.5281/zenodo.192641.

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Alphonso is the most delicious variety of mango (Mangifera indica L.) known for its excellent texture, taste, and richness with vitamins and minerals. The present study was attempted to evaluate the impact of Mr. Trivedi’s biofield energy treatment on morphological characteristics, quality, yield and molecular assessment of mango. A plot of 16 acres lands used for this study with already grown mango trees. This plot was divided into two parts. One part was considered as control, while another part was subjected to Mr. Trivedi’s biofield energy treatment without physically touc

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12

Oak, Pranjali, Vineet Jha, Ashish Deshpande, et al. "Transcriptional and translational perturbation in abiotic stress induced physiological activities and metabolic pathway networks in spongy tissue disorder of mango fruit." Postharvest Biology and Technology 188 (June 2022): 111880. http://dx.doi.org/10.1016/j.postharvbio.2022.111880.

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13

Shivashankara, K. S., and C. K. Mathai. "Relationship of leaf and fruit transpiration rates to the incidence of spongy tissue disorder in two mango (Mangifera indica L.) cultivars." Scientia Horticulturae 82, no. 3-4 (1999): 317–23. http://dx.doi.org/10.1016/s0304-4238(99)00018-7.

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14

Abhimannyu Kalne, Nachiket Kotwaliwale, Karan Singh, and Vijay Kumar Singh. "Non-Destructive Inspection of Mango Fruit Using Digital Radiography, Computed Tomography and Magnetic Resonance Imaging." Journal of Agricultural Engineering (India) 49, no. 4 (2024): 33–41. http://dx.doi.org/10.52151/jae2012494.1493.

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Presence of seed weevil, internal physiological disorders and spongy tissues are undesirable internal features that are often found in mangoes. Fruits affected by these defects many times do not show any external symptom, and thus

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Ariani, Dwi, and Pindobilowo. "White Sponge Nevus : Autosomal Dominant Genetic Disorder." Formosa Journal of Applied Sciences 2, no. 2 (2023): 215–22. http://dx.doi.org/10.55927/fjas.v2i2.2991.

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Background: The oral cavity is an anatomically part of the body that has complex tissues and structures and is covered by soft, moist, and flexible non-keratinized mucosa for mobility. In some individuals, normal variations can be found, one of which is the White Sponge Nevus (WSN). These lesions are usually in the form of patches of white plaque that can be found by a dentist. Purpose: To identify and be able to differentiate normal variation lesions from pathological lesions that have similar clinical features. Method: Based on reference sources/references obtained from articles, journals fo

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Filosto, Massimiliano, Giuliano Tomelleri, Paola Tonin, et al. "Neuropathology of mitochondrial diseases." Bioscience Reports 27, no. 1-3 (2007): 23–30. http://dx.doi.org/10.1007/s10540-007-9034-3.

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The term “mitochondrial diseases” (MD) refers to a group of disorders related to respiratory chain dysfunction. Clinical features are usually extremely heterogeneous because MD may involve several tissues with different degrees of severity. Muscle and brain are mostly affected, probably because of their high dependence on oxidative metabolism.Muscle can be the only affected tissue or involved as a part of a multi-system disease; ragged red fibers, accumulation of structurally altered mitochondria and cytochrome-c-oxidase (COX) negative fibers are the main pathological features.In mitochondrial

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17

Wei, Yanping, Tingting Wang, Ningning Zhang, et al. "LncRNA TRHDE-AS1 inhibit the scar fibroblasts proliferation via miR-181a-5p/PTEN axis." Journal of Molecular Histology 52, no. 2 (2021): 419–26. http://dx.doi.org/10.1007/s10735-021-09968-y.

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AbstractHypertrophic scar (HS), a fibroproliferative disorder caused by abnormal wound healing after skin injury, which is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. Recent studies have shown that some non-coding RNA implicated the formation of HS, but the mechanism remains unclear. In this study, we found that lncRNA TRHDE-AS1 was downregulated in HS tissues and HSFs, and the level of lncRNA TRHDE-AS1 negatively correlated with the level of miR-181a-5p in HS tissue and HSFs. Overexpressed lncRNA TRHDE-AS1 significantly suppressed miR-181a

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18

Bikovskiy, V. A., E. A. Ionova, and T. A. Anosova. "Medullary Sponge Kidney: Clinical and Radiological Manifestations." A.I. Burnasyan Federal Medical Biophysical Center Clinical Bulletin, no. 4 (December 2022): 41–51. http://dx.doi.org/10.33266/2782-6430-2022-4-41-51.

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The aim of the investigation was to present the results of dynamic ultrasound examination of the evolution of local changes accompanying kidney injury in comparison with the studied manifestations of pathomorphogenesis of renal injury. Dynamic ultrasound examination of 216 patients aged 2 to 16 years with kidney injury of varying severity was performed. The obtained data were compared with the results of X-ray examinations, intraoperative findings and pathomorphological conclusions. It was showed that polymorphic changes accompanying a renal injury can be differentiated based on the identifica

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19

Yamazaki, Hiroyuki, Satoshi Ohte, Henki Rotinsulu, et al. "Screening for Small Molecule Inhibitors of BMP-Induced Osteoblastic Differentiation from Indonesian Marine Invertebrates." Marine Drugs 18, no. 12 (2020): 606. http://dx.doi.org/10.3390/md18120606.

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Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder with heterotopic ossification (HO) in soft tissues. The abnormal activation of bone morphogenetic protein (BMP) signaling by a mutant activin receptor-like kinase-2 (ALK2) leads to the development of HO in FOP patients, and, thus, BMP signaling inhibitors are promising therapeutic applications for FOP. In the present study, we screened extracts of 188 Indonesian marine invertebrates for small molecular inhibitors of BMP-induced alkaline phosphatase (ALP) activity, a marker of osteoblastic differentiation in a C2C12 cell

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20

Qi, Tingting, Di Zhang, Xuting Shi, Minhui Li, and Hongbin Xu. "Decreased circUBAP2 Expression Is Associated with Preeclampsia by Limiting Trophoblast Cell Proliferation and Migration." Reproductive Sciences 28, no. 8 (2021): 2237–45. http://dx.doi.org/10.1007/s43032-020-00450-w.

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AbstractPreeclampsia (PE) is a common obstetric disease and a major cause of maternal, newborn, and fetal death. This condition is a multisystem disorder characterized by hypertension, proteinuria, and involvement of the kidney, liver, and nervous system. It is generally believed that the placenta is the main cause of PE. circRNAs are a special class of noncoding RNAs that can form covalently closed continuous ring structures with tissue-specific conservation, and they have been reported to play a wide range of regulatory functions in various diseases, including PE. In this study, we reported

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21

Liu, Wei, and Gao Yan. "The Emerging Role of Circular RNAs in Cerebral Vascular Disorders." European Neurology 84, no. 4 (2021): 230–36. http://dx.doi.org/10.1159/000515807.

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<b><i>Background:</i></b> Circular RNAs (circRNAs) are covalently closed circular noncoding RNAs that are expressed in various life forms. CircRNAs have many characteristics, such as structural stability and tissue-specific expression that contribute to their role as a microRNA (sponge in gene regulation. <b><i>Summary:</i></b> Recent evidence suggests that circRNAs play an important role in the pathogenesis of cerebrovascular diseases (CVDs); however, the exact mechanism remains controversial. CircRNAs that are related to CVDs have great clinica

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22

Hong, L., and J. J. Mao. "Tissue-engineered Rabbit Cranial Suture from Autologous Fibroblasts and BMP2." Journal of Dental Research 83, no. 10 (2004): 751–56. http://dx.doi.org/10.1177/154405910408301003.

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Craniosynostosis is a congenital disorder of premature ossification of cranial sutures, occurring in one of approximately every 2500 live human births. This work addressed a hypothesis that a cranial suture can be tissue-engineered from autologous cells. Dermal fibroblasts were isolated subcutaneously from growing rabbits, culture-expanded, and seeded in a gelatin scaffold. We fabricated a composite tissue construct by sandwiching the fibroblast-seeded gelatin scaffold between two collagen sponges loaded with recombinant human BMP2. Surgically created, full-thickness parietal defects were fill

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Neto, Ana, and José Ferreira. "Synthetic and Marine-Derived Porous Scaffolds for Bone Tissue Engineering." Materials 11, no. 9 (2018): 1702. http://dx.doi.org/10.3390/ma11091702.

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Bone is a vascularized and connective tissue. The cortical bone is the main part responsible for the support and protection of the remaining systems and organs of the body. The trabecular spongy bone serves as the storage of ions and bone marrow. As a dynamic tissue, bone is in a constant remodelling process to adapt to the mechanical demands and to repair small lesions that may occur. Nevertheless, due to the increased incidence of bone disorders, the need for bone grafts has been growing over the past decades and the development of an ideal bone graft with optimal properties remains a clinic

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Wu, Yueh-Lin, Hsiao-Fen Li, Hsi-Hsien Chen, and Heng Lin. "Emergent Roles of Circular RNAs in Metabolism and Metabolic Disorders." International Journal of Molecular Sciences 23, no. 3 (2022): 1032. http://dx.doi.org/10.3390/ijms23031032.

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Circular RNAs (circRNAs) are an emerging group of long non-coding RNAs (lncRNAs) and have attracted attention again according to the progress in high-throughput sequencing in recent years. circRNAs are genome transcripts produced from pre-messenger (m)RNA regions in a specific process called “back-splicing,” which forms covalently closed continuous loops. Due to their lack of a 5’ cap and 3’ poly-adenylated tails, circRNAs are remarkably more stable than linear RNAs. Functionally, circRNAs can endogenously sponge to microRNAs, interact with RNA-binding proteins (RBPs), or translate themselves.

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Samchenko, Y. M., A. P. Maletsky, L. O. Kernosenko, et al. "Sponge-like hybrid hydrogels for endoprosthetics in oculo-orbital area." Himia, Fizika ta Tehnologia Poverhni 15, no. 4 (2024): 574–82. http://dx.doi.org/10.15407/hftp15.04.574.

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In recent years, significant progress has been made in both the synthesis of metal nanoparticles and the creation of hydrogel platforms. It is assumed that their synergistic combination will allow to create the advanced hydrogel nanocomposites for the repair of anatomical and functional disorders of the human body, as well as for the needs of reconstructive surgery. The aim of the study is to develop a porous polymeric material based on polyvinylformal with incorporated functional hydrogels and gold nanoparticles, the study of its physicochemical properties and biocompatibility in vitro and in

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Kordiyak, О. Y., K. A. Moroz, Z. M. Honta, O. M. Nemesh, and I. V. Shylivskyi. "MINERAL COMPOSITION OF MANDIBULAR BONE TISSUE IN SIMULATED PERIODONTITIS DURING METABOLIC ACIDOSIS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 24, no. 1 (2024): 94–99. http://dx.doi.org/10.31718/2077-1096.24.1.94.

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Destructive changes in the mandibular cancellous bone tissue determine the severity of periodontal diseases and affect their treatment outcomes. The imbalance between macro- and microelements leads to structural and functional changes in the spongy bone tissue of the lower jaw, and when being combined with the inflammatory process in the soft tissues of the periodontium leads to the tooth loss. Mineral elements deposited in the bones are included in the body buffer systems and are able to influence the metabolic processes of the macroorganism by mobilizing them into the bloodstream. The

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Bakhti, Seyedeh Zahra, Sana Dadashi, Anahita Dah Pahlevan, and Fatemeh Kafshresan. "Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review." International Clinical Neuroscience Journal 8, no. 4 (2021): 157–67. http://dx.doi.org/10.34172/icnj.2021.33.

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Circular RNAs (circRNAs) are a complicated class of non-coding RNAs that have a covalently closed loop structure and are very stable and cautious. Multiple biological processes of malignancy, including tumorigenesis, development, invasion, metastasis, apoptosis, and vascularization, are disrupted by an increased number of circRNAs. Recent research has showed that circRNAs, functioning as microRNA (miRNA) sponges or protein scaffolds, interacting with RNA-binding proteins (RBPs), and autophagy regulators, affect the transcription and splicing regulation. Many circRNAs have tissue-specific expre

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Marczyński, Wojciech, Witold Tłustochowicz, Wiesław Tomaszewski, and Jerzy Białecki. "Literature Analysis Regarding the Combination of Substances: Glucosamine + Chondroitin in the Treatment of Osteoarthritis." Ortopedia Traumatologia Rehabilitacja 24, no. 6 (2022): 407–16. http://dx.doi.org/10.5604/01.3001.0016.2326.

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An essential component of joint quality is cartilage. Therefore, the protection of this is a prerequisite for maintaining the condition of each joint. The assessment of the presence of articular cartilage is shown by X-ray of both joints in the standing position. Cartilage protection is possible for 1, 2 and 3 degree of cartilage damage according to the Kellgren and Lawrence scale.The challenge for the physician is to identify the cause of OA in accordance with the principles of Evidence Based Orthopedics/Traumatology, and not merely treat symptomatically, which is usually ineffective.In order

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KUMAR, AJEET. "Adaptation strategies for horticultural crops under changing climate conditions: A review." Annals of Plant and Soil Research 26, no. 3 (2024): 359–71. https://doi.org/10.47815/apsr.2024.10373.

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Climate change variability and its impacts are a major global problem in the 21st century. The physiological reactions of horticulture crops to climate changes, such as decreased growing period, are negatively affected by terminal heat stress and limited soil water availability. This leads to a significant decrease in the output of fruits and vegetables, ultimately impacting the growth and development of these crops. The variability of climate change has adverse consequences on horticulture crops, including lower irrigation water availability, increased warmth, flooding, salt, and a negative i

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della Vella, Fedora, Dorina Lauritano, Carlo Lajolo, et al. "The Pseudolesions of the Oral Mucosa: Differential Diagnosis and Related Systemic Conditions." Applied Sciences 9, no. 12 (2019): 2412. http://dx.doi.org/10.3390/app9122412.

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Pseudolesions are defined as physiological or paraphysiological changes of the oral normal anatomy that can easily be misdiagnosed for pathological conditions such as potentially malignant lesions, infective and immune diseases, or neoplasms. Pseudolesions do not require treatment and a surgical or pharmacological approach can constitute an overtreatment indeed. This review aims to describe the most common pseudolesions of oral soft tissues, their possible differential diagnosis and eventual related systemic diseases or syndromes. The pseudolesions frequently observed in clinical practice and

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Omelchenko, Artem, and Andrey Kopchak. "Donor-site morbidity after using bone autoplastic in reconstructive maxillofacial surgery. Meta-analysis." Ukrainian Scientific Medical Youth Journal 154, no. 2 (2025): 132–43. https://doi.org/10.32345/usmyj.2(154).2025.132-143.

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the problem of donor-site diseases is an integral and important aspect of reconstructive surgical treatment using autografts. In maxillofacial surgery, autografts from the fibula and iliac crest are widely used to replace large defects of the lower and upper jaws. This approach to restoring lost bone structures is currently the “gold standard” due to the fact that bone autografts have the lowest risk of rejection compared to other options for bone grafting and provide the best anatomical and functional results in the long-term postoperative period. Donor site diseases are divided into early an

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Maurya, Aklesh K., Anand K. Yadav, Pankaj Kumar, Ram K. Pandey, and Ashish K. Singh. "Outcome of substitutional urethroplasty by using dorsal onlay buccal mucosal graft: our experience of 10 years." International Journal of Research in Medical Sciences 12, no. 5 (2024): 1549–54. http://dx.doi.org/10.18203/2320-6012.ijrms20241240.

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Background: The term urethral stricture is anterior urethral disease, or a scarring process involving the spongy erectile tissue of the corpus spongiosum. Methods: Total 127 patients were included in the study. Patient selection criteria for urethroplasty by using buccal mucosal graft was length of stricture more than 2 cm, deep spongiofibrosis, failed optical urethrotomy for 3 times, adequate oral hygiene and proper buccal mucosa. Results: Length of stricture varied from 3.2 to 14 cm. In first postoperative week, 20.47% (n=26) patients developed minor wound infection culture negative seroma f

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Shan, Dan, Gabriel Rezonzew, Sean Mullen, et al. "Heterozygous Pkhd1C642* mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidney." American Journal of Physiology-Renal Physiology 316, no. 3 (2019): F463—F472. http://dx.doi.org/10.1152/ajprenal.00181.2018.

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Heterozygosity for human polycystic kidney and hepatic disease 1 ( PKHD1) mutations was recently associated with cystic liver disease and radiographic findings resembling medullary sponge kidney (MSK). However, the relevance of these associations has been tempered by a lack of cystic liver or renal disease in heterozygous mice carrying Pkhd1 gene trap or exon deletions. To determine whether heterozygosity for a smaller Pkhd1 defect can trigger cystic renal disease in mice, we generated and characterized mice with the predicted truncating Pkhd1C642* mutation in a region corresponding to the mid

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Druzhinin, Valentin N., Vadim G. Suvorov, Aleksandr N. Cherniy, and Sergey N. Troinyakov. "Precision X-ray diagnosis of osteoporosis in representatives of risk groups for the appearance and development of varicose disease of the lower limbs." Russian Journal of Occupational Health and Industrial Ecology 60, no. 12 (2020): 911–17. http://dx.doi.org/10.31089/1026-9428-2020-60-12-911-917.

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Introduction. Varicose disease of the lower limbs (VDLL) is an independent disease and is an important medical and social problem due to its widespread and tendency to progress among people of working age and mainly in the female half of the population. Features of professional activity are risks in the form of static loads of a constant nature or weightlifting and other risk factors (for example, genetic predisposition, hormonal imbalance during pregnancy and menopause, obesity, diabetes mellitus, hypercoagulation, treatment with hormonal drugs, irrational nutrition, alcohol abuse, the presen

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D’Anca, Marianna, Francesca R. Buccellato, Chiara Fenoglio, and Daniela Galimberti. "Circular RNAs: Emblematic Players of Neurogenesis and Neurodegeneration." International Journal of Molecular Sciences 23, no. 8 (2022): 4134. http://dx.doi.org/10.3390/ijms23084134.

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In the fascinating landscape of non-coding RNAs (ncRNAs), circular RNAs (circRNAs) are peeping out as a new promising and appreciated class of molecules with great potential as diagnostic and prognostic biomarkers. They come from circularization of single-stranded RNA molecules covalently closed and generated through alternative mRNA splicing. Dismissed for many years, similar to aberrant splicing by-products, nowadays, their role has been regained. They are able to regulate the expression of linear mRNA transcripts at different levels acting as miRNA sponges, interacting with ribonucleoprotei

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Yu, Cheng-Chia, Yi-Wen Liao, Pei-Ling Hsieh, and Yu-Chao Chang. "Targeting lncRNA H19/miR-29b/COL1A1 Axis Impedes Myofibroblast Activities of Precancerous Oral Submucous Fibrosis." International Journal of Molecular Sciences 22, no. 4 (2021): 2216. http://dx.doi.org/10.3390/ijms22042216.

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Oral submucous fibrosis (OSF) is known as a potentially malignant disorder, which may result from chemical irritation due to areca nuts (such as arecoline). Emerging evidence suggests that fibrogenesis and carcinogenesis are regulated by the interaction of long noncoding RNAs (lncRNAs) and microRNAs. Among these regulators, profibrotic lncRNA H19 has been found to be overexpressed in several fibrosis diseases. Here, we examined the expression of H19 in OSF specimens and its functional role in fibrotic buccal mucosal fibroblasts (fBMFs). Our results indicate that the aberrantly overexpressed H1

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Su, Jia, Yiqi Zhao, Wei-Dong Chen, and Yan-Dong Wang. "Activation of the G Protein-Coupled Bile Acid Receptor TGR5 Modulates the HCP5/miR-139-5p/DDIT4 Axis to Antagonize Cervical Cancer Progression." International Journal of Molecular Sciences 25, no. 16 (2024): 8932. http://dx.doi.org/10.3390/ijms25168932.

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A growing body of evidence indicates that the G protein-coupled bile acid receptor, TGR5, plays a critical role in multiple physiological processes ranging from metabolic disorders to cancers. However, the biological functions of TGR5 in cervical cancer (CC) have not been elucidated. Here, using TGR5 knockout mice, we found that a deficiency of TGR5 leads to greater sensitivity to the progression of cervical inflammation. Activation of TGR5 by its specific ligands significantly attenuated the malignant behavior of CC cells. In addition, we found that TGR5 can negatively modulate the expression

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Diachkova, G. V., A. S. Sudnitsyn, N. M. Klyushin, A. V. Burtsev, K. A. Diachkov та E. V. Khieva. "Neurogenic Аrthropathy, Сhronic Osteomyelitis, Diabetic Foot: Differential X-Ray and MSCT Diagnostics". Radiology - Practice, № 1 (1 лютого 2023): 10–29. http://dx.doi.org/10.52560/2713-0118-2023-1-10-29.

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X-ray and MSCT-differential diagnostics between neurogenic arthropathy, diabetic osteoneuroarthropathy (DONAP), complicated by osteomyelitis and chronic osteomyelitis, has not been studied enough.The purpose of the study was to study the MSCT semiotics of various variants of neurogenic arthropathy, DONAP complicated by osteomyelitis and chronic post-traumatic osteomyelitis in order to substantiate etiopathogenetic treatment. In 44 patients with neurogenic arthropathy, DONAP, complicated by osteomyelitis and chronic osteomyelitis, the results of polypositional radiography, MSCT were studied bef

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Cánovas-Cervera, Irene, Elena Nacher-Sendra, Rebeca Osca-Verdegal, et al. "The Intricate Role of Non-Coding RNAs in Sepsis-Associated Disseminated Intravascular Coagulation." International Journal of Molecular Sciences 24, no. 3 (2023): 2582. http://dx.doi.org/10.3390/ijms24032582.

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Disseminated Intravascular Coagulation (DIC) is a type of tissue and organ dysregulation in sepsis, due mainly to the effect of the inflammation on the coagulation system. Unfortunately, the underlying molecular mechanisms that lead to this disorder are not fully understood. Moreover, current biomarkers for DIC, including biological and clinical parameters, generally provide a poor diagnosis and prognosis. In recent years, non-coding RNAs have been studied as promising and robust biomarkers for a variety of diseases. Thus, their potential in the diagnosis and prognosis of DIC should be further

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Vashchenko, Vladimir I., Alexey B. Chuklovin, and Petr D. Shabanov. "Circular RNAs in eukaryotic cells: origin, characteristics, mechanisms of molecular functioning in human malignant diseases." Reviews on Clinical Pharmacology and Drug Therapy 20, no. 4 (2023): 335–84. http://dx.doi.org/10.17816/rcf204335-384.

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Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with limited functionality. However, recent advances in highthroughput genomic technology have allowed circRNAs to be characterized in detail and revealed their important functions in controlling various biological and molecular processes, the most essential being gene regulation. Due to structural stability, high expression, availability of microRNA (miRNA) binding sites and tissue-s

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Osmanova, G. Ya, V. A. Aleksandrov, A. V. Aleksandrov, et al. "Antibodies to cyclic citrullinated peptide and angiopoietin-like protein type 4 as markers of immune inflammation and osteoporotic processes in rheumatoid arthritis patients." Medical Immunology (Russia) 26, no. 2 (2023): 393–400. http://dx.doi.org/10.15789/1563-0625-atc-2862.

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Low-energy fractures in rheumatoid arthritis (RA) are more common in patients with high activity and long duration of disease, and with high titers of anti-citrullinated antibodies (ACPA). Increased expression of angiopoietin-like protein type 4 (ANGPTL4) in bone tissue has also been noted in inflammatory arthritis. The purpose of the present study was to analyze the effect of ACPA and ANGPTL4 on systemic bone mineral density in RA patients. Antibodies to ACPA and ANGPTL4 content were detected in blood serum of 96 RA patients (women, 91.7%) by enzyme immunoassay. Mineral density of the lumbar

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Price, Lauren E., Abigail B. Loewen Faul, Aleksandra Vuchkovska, et al. "Molecular Genetic Analysis of Rbm45/Drbp1: Genomic Structure, Expression, and Evolution." Journal of Student Research 7, no. 2 (2019): 49–61. http://dx.doi.org/10.47611/jsr.v7i2.426.

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RNA recognition motif-type RNA-binding domain containing proteins (RBDPs) participate in RNA metabolism including regulating mRNA stability, nuclear-cytoplasmic shuttling, and splicing. Rbm45 is an RBDP first cloned from rat brain and expressed spatiotemporally during rat neural development. More recently, RBM45 has been associated with pathological aggregates in the human neurological disorders amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer’s. Rbm45 and the neural developmental protein musashi-1 are in the same family of RDBPs and have similar expression patte

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Vuchkovska, Virdjinija, Teagan N. Marti, Anali Cisneros, Lauren M. Saiki, and Jeffrey O. Henderson. "Rbm45 Phylogenetics, Protein Domain Conservation, and Gene Architecture in Clade Metazoa." Journal of Evolutionary Science 1, no. 3 (2024): 13–34. http://dx.doi.org/10.14302/issn.2689-4602.jes-24-4982.

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Mammalian Rbm45 is predominately expressed in neuronal tissue and is integral in brain development and neuronal differentiation under physiological conditions. Dysregulation of Rbm45 has been strongly associated with neurodegenerative disorders in humans and can drive hepatocellular carcinoma through reprogramming lipid metabolism. Intriguingly, Rbm45 is an ancient protein, evolutionarily conserved throughout metazoans, including in sponges which lack a nervous system. Curiously, the evolution of Rbm45 gene structure and protein domain conservation across kingdom Animalia is largely unknown. W

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Espin Palazon, Raquel, Xiaoyi Cheng, Clyde A. Campbell, Liangdao Li, Bettina Schmid, and David Traver. "Zebra "Fishing" the Role of Granulin in Hematopoiesis." Blood 134, Supplement_1 (2019): 1194. http://dx.doi.org/10.1182/blood-2019-130781.

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Granulin (GRN) is a multifunctional protein with anti-inflammatory properties and involved in neurological diseases and tumorigenesis. It contains several cysteine-rich motifs that are unique to this protein, which are conserved from sponges to humans indicating their ancient evolutionary origin. Despite being highly expressed by certain hematopoietic cell lineages, the role that GRN plays in hematopoiesis has reminded elusive. The multifunctional nature of this protein, together with its wide expression in all mammalian cell types has challenged the characterization of its functional role in

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Kiran, Patil R., Parth Jadhav, G. Avinash, et al. "Detection and classification of spongy tissue disorder in mango fruit during ripening by using visible-near infrared spectroscopy and multivariate analysis." Journal of Near Infrared Spectroscopy, August 13, 2024. http://dx.doi.org/10.1177/09670335241269005.

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The esteemed Alphonso mango, cherished in India for its taste, saffron color, texture, and extended shelf life, holds global commercial appeal. Unfortunately, the prevalent spongy tissue disorder in Alphonso mangoes results in a soft and corky texture, with up to 30% of mangoes within a single batch affected. This issue leads to outright rejection during export due to delayed disorder identification. The current assessment method involves destructive sampling, causing substantial fruit loss, and lacks assurance for overall batch quality. In light of the mentioned challenges, this current study

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Kiran, Patil Rajvardhan, Md Yeasin, Pramod Aradwad, T. V. Arunkumar, and Roaf Ahmad Parray. "Advancing mango quality assurance: Non‐destructive detection of spongy tissue using visible near‐infrared spectroscopy and machine learning classification." Future Postharvest and Food, July 2024. http://dx.doi.org/10.1002/fpf2.12023.

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AbstractThe renowned Alphonso mango, celebrated in India for its exquisite taste, saffron hue, pleasing texture, and prolonged shelf life, holds significant global commercial appeal. Unfortunately, the widespread issue of spongy tissue (ST) disorder in Alphonso mangoes results in a soft, corky texture, affecting up to 30% of mangoes in a single batch. This challenge leads to the outright rejection of affected mangoes during export due to delayed disorder identification. The current evaluation method involves destructive cutting, causing substantial fruit loss, and lacks assurance for the overa

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Kiran, Patil Rajvardhan, G. Avinash, Mrinmoy Ray, Sapna Nigam, and Roaf Ahmad Parray. "Deep learning models for detection and classification of spongy tissue disorder in mango using X-ray images." Journal of Food Measurement and Characterization, July 24, 2024. http://dx.doi.org/10.1007/s11694-024-02766-6.

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Kiran, Patil Rajvardhan, Parth Jadhav, Roaf Ahmad Parray, and Manish Srivastav. "Physiological and Biochemical Attributes Associated with Spongy Tissue Disorder in Mangifera Indica L CV Alphonso during Ripening." Acta Scientific Agriculture, June 1, 2024, 33–42. http://dx.doi.org/10.31080/asag.2024.08.1379.

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Shivashankar, Seshadri, and Manoharan Sumathi. "Rapid burst of ethylene evolution by premature seed: A warning sign for the onset of spongy tissue disorder in Alphonso mango fruit?" Journal of Biosciences 44, no. 6 (2019). http://dx.doi.org/10.1007/s12038-019-9957-4.

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Mahendra, Trivedi, Branton Alice, Trivedi Dahryn, and Nayak Gopal. "Morphological Characterization, Quality, Yield and DNA Fingerprinting of Biofield Energy Treated Alphonso Mango (Mangifera indica L.)." Science Publishing Group, December 22, 2015. https://doi.org/10.5281/zenodo.813689.

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Alphonso is the most delicious variety of mango (Mangifera indica L.) known for its excellent texture, taste, and richness with vitamins and minerals. The present study was attempted to evaluate the impact of Mr. Trivedi's biofield energy treatment on morphological characteristics, quality, yield and molecular assessment of mango. A plot of 16 acres lands used for this study with already grown mango trees. This plot was divided into two parts. One part was considered as control, while another part was subjected to Mr. Trivedi's biofield energy treatment without physically touching and referred

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