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Dissertations / Theses on the topic 'SPR - Surface Plasmon Resonance'

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Published: 4 June 2021
Last updated: 1 February 2022

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1

Du, Yao. "Particle-modified surface plasmon resonance biosensor." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289388.

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Surface plasmon resonance (SPR) biosensors have attracted great attention in scientific research in the past three decades. Extensive studies on the immobilisation of biorecognition elements have been conducted in pursuit of higher sensitivity, but trialled formats have focussed on a thin layer modification next to the plasmon film, which usually requires in situ derivatization. This thesis investigates an 'off-chip' immobilisation strategy for SPR biosensing using silica particles and considers the implications of a particle-modified evanescent field on the signal amplitude and kinetics, for
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2

Wijaya, Edy. "Design and optimization of Surface Plasmon Resonance (SPR) biosensors." Thesis, Lille 1, 2012. http://www.theses.fr/2012LIL10096/document.

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En terme de performance, le biocapteur idéal doit avoir très grande sensibilité, basse limite de détection et temps d’analyse qui est extrêmement court. Les biocapteurs sans marquage à base de résonance de plasmons de surface (biocapteurs SPR) possèdent naturellement le temps d’analyse le plus court parmi différent types de biocapteurs. Leur limite de détection n’est cependant pas la plus impressionnante. Il y a donc un besoin pour augmenter considérablement la sensibilité intrinsèque des biocapteurs SPR afin de permettre de plus basses limites de détection. Quelques approches pour exalter la
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3

Prabhu, G. Radhakrishna. "Studies On Surface Plasmon Resonance And Related Experimental Methods Using Fixed Plasmon Angle." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/205.

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Surface plasmon waves are transverse magnetic electromagnetic waves propagating along a dielectric-metal interface. These waves can be excited by resonant absorption of electromagnetic radiation leading to surface plasmon resonance (SPR) at the interface. The resonance is characterised by a reduction in the intensity of the reflected light at the interface due to strong coupling of incident optical radiation to surface plasmons. This gives rise to a minimum at a sharply defined angle of incidence, referred to as SPR angle or plasmon angle. The phenomenon of SPR has been extensively used in the
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4

See, Erich Michael. "Modeling Plasmon Resonance for a Gold Nanoparticle Plasmon-Enhanced Cadmium Sulfide Biosensor." Miami University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=miami1249499557.

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5

Bang, Hyungseok. "INTEGRATED OPTICAL SPR (SURFACE PLASMON RESONANCE) SENSOR BASED ON OPTOELECTRONIC PLATFORM." Doctoral diss., University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3289.

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Current major demands in SPR sensor development are system miniaturization and throughput improvement. Structuring an array of integrated optical SPR sensor heads on a semiconductor based optoelectronic platform could be a promising solution for those issues, since integrated optical waveguides have highly miniaturized dimension and the optoelectronic platform enables on-chip optical-to-electrical signal conversion. Utilizing a semiconductor based platform to achieve optoelectronic functionality poses requirements to the senor head; the sensor head needs to have reasonably small size while it
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Bathae, Kumaresh Prasanth. "OPTIMIZATION OF A DUAL-MODE SURFACE PLASMON RESONANCE SENSOR." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_theses/424.

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Surface plasmon waves are TM polarized charge density waves that propagate at the interface of two media with real dielectric constants of opposite sign (i.e. liquid dielectric and certain metals). Surface plasmon resonance (SPR) sensors use these waves to detect refractive index changes adjacent to the metal layer. Refractive index changes arise from the binding of an analyte (e.g. a target molecule, protein, or bacterium) to the functionalized metal layer or from interfering effects such as changes in solution index. Standard, single channel SPR sensors cannot differentiate these two effects
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Badjatya, Vaibhav. "TUNABLE LASER INTERROGATION OF SURFACE PLASMON RESONANCE SENSORS." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_theses/588.

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Surface plasmons are bound TM polarized electromagnetic waves that propagate along the interface of two materials with real dielectric constants of opposite signs. Surface plasmon resonance (SPR) sensors make use of the surface plasmon waves to detect refractive index changes occurring near this interface. For sensing purposes, this interface typically consists of a metal layer, usually gold or silver, and a liquid dielectric. SPR sensors usually measure the shift in resonance wavelength or resonance angle due to index changes adjacent to the metal layer. However this restricts the limit of de
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8

Subramanian, Kannan. "Kinetics of insulin - insulin receptor interaction using a surface plasmon resonance (SPR)." Thesis, University of Canterbury. Chemical and Process Engineering, 2014. http://hdl.handle.net/10092/9327.

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Type 2 diabetes or adult onset diabetes, has been a global epidemic for the past two decades, and the number of new cases accelerates every year. Insulin resistance is one of the major factors behind this, wherein the insulin receptor, which signals to regulate glucose levels, based on the hormone insulin, loses its sensitivity. Obesity is one other major concern which is caused due to the improper balance between the caloric intake and the energy utilized. Gastric bypass surgeries (GBP) are performed to avert obesity. However, a beneficial side-effect is that the state of insulin resistance i
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9

Earp, Ronald Lee Jr. "Multiwavelength Surface Plasmon Resonance Sensor Designs for Chemical and Biochemical Detection." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/30581.

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Surface plasmon resonance (SPR) sensors using multiwavelength light coupling are investigated to probe changes in refractive index that occur as a result of chemical or biochemical processes. Traditional SPR sensors have used angle modulation to facilitate detection at the sensor surface; however, the multiwavelength approach is novel and brings new functionality to SPR sensors. The multiwavelength sensors are constructed on both fiber optic and bulk waveguides such as prisms. A thin metal film is deposited on the waveguide surface to support the surface plasmon (SP) mode. The evanescent
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10

Nordström, Helena. "Fragment Based Drug Discovery with Surface Plasmon Resonance Technology." Doctoral thesis, Uppsala universitet, Biokemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209136.

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Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. The focus of the two projects was different. Many MMP inhibitors contain a strong zinc chelating group, hydroxamate, interacting with the catalytic zinc atom. This strategy may be the cause for the low specificity of MMP inhibitors. Using FBDD we found a fr
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11

Guo, Jing. "MULTI-MODE SELF-REFERENCING SURFACE PLASMON RESONANCE SENSORS." UKnowledge, 2013. http://uknowledge.uky.edu/ece_etds/13.

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Surface-plasmon-resonance (SPR) sensors are widely used in biological, chemical, medical, and environmental sensing. This dissertation describes the design and development of dual-mode, self-referencing SPR sensors supporting two surface-plasmon modes (long- and short-range) which can differentiate surface binding interactions from bulk index changes at a single sensing location. Dual-mode SPR sensors have been optimized for surface limit of detection (LOD). In a wavelength interrogated optical setup, both surface plasmons are simultaneously excited at the same location and incident angle but
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12

Sommers, Daniel R. "Design and verification of a surface plasmon resonance biosensor." Thesis, Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/6967.

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The Microelectronics Group has been researching sensors useful for detecting and quantifying events in biological molecular chemistry, for example, binding events. Our previous research has been based primarily on quartz resonators. This thesis describes the results of our initial research of Surface Plasmon Resonance (SPR) based technology. This study contains the design and implementation of a fully functional SPR biosensor with detailed disclosure of monolayer construction, digital hardware interfaces and software algorithms for process the SPR sensors output. An antibody monolayer was c
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Matcheswala, Akil Mannan. "GOLD NANOSPHERES AND GOLD NANORODS AS LOCALIZED SURFACE PLASMON RESONANCE SENSORS." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_theses/60.

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A novel localized surface plasmon resonance (LSPR) sensor that differentiates between background refractive index changes and surface-binding of a target analyte (e.g. a target molecule, protein, or bacterium) is presented. Standard, single channel LSPR sensors cannot differentiate these two effects as their design allows only one mode to be coupled. This novel technique uses two surface plasmon modes to simultaneously measure surface binding and solution refractive index changes. This increases the sensitivity of the sensor. Different channels or modes can be created in sensors with the intro
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14

Adducci, Benjamin Augustus. "Detection of a Surrogate Biological Threat Agent (Bacillus globigii) with a Portable Surface Plasmon Resonance Biosensor." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/73535.

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New methods and technology are needed to detect biological agents that threaten the health of humans and domestic animals. The bacterium Bacillus anthracis, causal agent of anthrax, has been used as a biological warfare agent. Here, we extend the work of Chinowksy et al. (2007) to the detection of a surrogate of B. anthracis, B. globigii (also known as B. atrophaeus, B. subtilis var. niger, B. subtilis var. subtilis) in a mixed sample containing two different species of Bacillus using a portable surface plasmon resonance (SPR) biosensor (SPIRIT 4.0, Seattle Sensor Systems). Two methods (direct
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15

Wathen, Adam D. "An Exploration of Electron-Excited Surface Plasmon Resonance for Use In Biosensor Applications." Thesis, Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5240.

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Electron-excited surface plasmon resonance (eSPR) is investigated for potential use in biosensors. Optical SPR sensors are commercially available at present and these sensors are extremely sensitive, but have the tendency to be relatively large, expensive, and ignore the potentials of microelectronic technology. By employing the use of various microelectronic and nanotechnology principles, the goal is to eventually design a device that exploits the eSPR phenomenon in order to make a sensor which is siginificantly smaller in size, more robust, and cheaper in cost.
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16

Shumaker-Parry, Jennifer Sue. "Quantitative aspects of SPR spectroscopy and SPR microscopy, applications in protein binding to immobilized vesicles and dsDNA arrays /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/11600.

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17

Nohldén, Sofia. "Affinity Determination of Protein A Domains to IgG subclasses by Surface Plasmon Resonance." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11340.

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<p>A capture step with protein A is the most common purification step in the downstream purification process of monoclonal antibodies. It is therefore of great importance to increase the knowledge of the interactions involved in this purification technique. The purpose of this master thesis project was to determine the affinity of protein A domains to IgG subclasses by surface plasmon resonance (SPR).</p><p>Besides the five homologous IgG-binding protein A domains (E, D, A, B, and C) an engineered domain, similar to domain B and used in the protein A media MabSelect Sure™ (GE Healthcare) was i
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18

Ekström, Emma. "SPR-based method for concentration determination of proteins in a complex environment." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181524.

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In this project a method based on surface plasmon resonance has been developed for determining the concentration of several His-tagged proteins in complex solutions. It showed large dynamic range, no measureable non-specific binding and high sensitivity (with linear range around 0.1–10 μg/ml depending on the proteins). The method showed a low variation when checked on MBP-His during an extended time period. The concentrations of the His-tagged protein in the lysate has also been determined and compared with other alternative methods. This method will later be used to analyse protein concentrat
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19

SÁNCHEZ, JOHN EDICSON HERNÁNDEZ. "ASSEMBLY OF A SURFACE PLASMON RESONANCE (SPR) SPECTROMETER FOR THE CHARACTERIZATION OF THIN ORGANIC FILMS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2013. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=35147@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO<br>COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR<br>PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO<br>Espectroscopia de ressonância plasmônica de superfície (SPR) é uma técnica óptica amplamente utilizada para monitorizar as alterações físicas ou químicas que ocorrem em uma interface metal - dielétrico. A medição simultânea da espessura e do índice de refração de filmes finos orgânicos, adsorvidos ou depositados sobre a superfície plana de um metal, requer duas medições independentes seguindo uma metodologia designada n
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Gamsjaeger, Roland. "AFM and SPR on biological systems applying atomic force microscopy (AFM) and surface plasmon resonance (SPR) to biologically important systems." Saarbrücken VDM Verlag Dr. Müller, 2007. http://d-nb.info/988909820/04.

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21

Sultan, Mansoor A. "ELECTRON-BEAM PATTERNING OF TEFLON AF FOR SURFACE PLASMON RESONANCE SENSING." UKnowledge, 2015. http://uknowledge.uky.edu/ece_etds/66.

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Variable pressure electron beam etching and lithography for Teflon AF has been demonstrated. The relation between dose and etching depth is tested under high vacuum and water vapor. High resolution structures as small as 75 nm half-pitch have been resolved. Several simulation tools were tested for surface plasmon excitation. Grating based dual mode surface plasmon excitation has been shown numerically and experimentally.
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22

Kirtland, David Rand. "Preparation of Heparin Surface for Quantification of Fibroblast Growth Factor-2 (FGF-2) Binding Using Surface Plasmon Resonance (SPR)." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/33265.

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A mixed self assembling monolayer (mSAM) chip with attached heparin was developed to analyze heparin-protein interactions using a Reichert Inc, SR7000, surface plasmon resonance (SPR) instrument. The heparin was attached via streptavidin-biotin linkage where the streptavidin was covalently coupled to the mSAM and biotinylated heparin bound to it. These chips were then used to quantify the interactions of fibroblast growth factor-2 (FGF-2) with the surface bound heparin. Kinetic rate constants of association and disassociation were calculated. The association data of FGF-2 with heparin was
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See, Erich M. "Plasmon Directed Chemical Reactivity and Nanoparticle Self-Assembly." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/85400.

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Nanotechnology has advanced to the point that nanoparticles can now be fabricated in a broad variety of shapes from a wide range of materials, each with their own properties and uses. As the list of manufacturable particles continues to grow, a new frontier presents itself: assembling these existing nanoparticles into more complicated nanoscale structures. The primary objective of this thesis is to demonstrate and characterize one such method of nanoscale construction, the plasmonically directed self-assembly of gold nanospheres onto both silver nanospheroids and gold nanorods. At the heart o
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Canelle, Quentin. "Real Time Surface Plasmon Resonance Biosensors, a Powerful Technology to Assess Polyclonal Antibody Avidity." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/216754.

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The present research focused on the development of a new methodology to assess the strength of the interaction between vaccine antigens and elicited polyclonal antibodies through SPR biosensors. Quantifying the binding strength of polyclonal antibodies is of first importance to evaluate the quality of the vaccine as well as to increase the scientific knowledge of immune protection mechanisms. To now the development of such tool has been complicated by the non-specific binding caused by high protein abundance in the blood and serum samples but also by the way of interpreting the data resulting
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Kärnhall, Johan. "New SPR based assays for plasma protein titer determination." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70044.

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Reliable analytical tools are important for time efficient and economical process development, production and batch release of pharmaceuticals. Therapeutics recovered from human plasma, called plasma protein products, involve a large pharmaceutical industry of plasma fractionation. In plasma fractionation of human immunoglobulin G (hIgG) and albumin (HSA) recommended analysis techniques are regulated by the European Pharmacopoeia and are including total protein concentration assays and zone electrophoresis for protein composition and purity. These techniques are robust, but more efficient tech
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Cao, Yihong. "Sugar and Peptide mimics for SPR Characterization of autoantibodies in monoclonal gammopathy." Phd thesis, Université de Cergy Pontoise, 2013. http://tel.archives-ouvertes.fr/tel-00877262.

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IgM monoclonal gammopathy is a common age-related demyelinating sensory and motor polyneuropathy. It has been shown to be associated with antibodies against myelin-associated glycoproteins (MAG/SGPG). The HNK-1 carbohydrate epitope is a terminal 3-sulfo-glucuronyl residue attached to lactosamine structures and it is shared both in MAG and SGPG (SO4-3-GlcA(β1-3)Gal-(β1-4)GlcNAc(β1-3)Gal-(β1-4)Glcβ(1-1′)Cer). It is mostly expressed in the nervous system and plays an important role in preferential motor reinnervation. Nevertheless, the HNK-1 epitope is difficult to be isolated and synthesized and
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Sanchez, Erik De Jesus. "Modeling of the Surface Plasmon Resonance (SPR) Effect for a Metal-Semiconductor (M-S) Junction at Elevated Temperatures." PDXScholar, 1993. https://pdxscholar.library.pdx.edu/open_access_etds/4624.

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The effect of temperature increase on the optical excitation of Surface Plasmon Resonance (SPR) at an Ag-Si metal-semiconductor (M-S) junction at a wavelength of 1 . 1 52 pm is investigated theoretically using computer modeling in Fortran. In order to accurately quantify the SPR, the temperature dependent optical constants for Ag and Si are obtained theoretically or semiempirically , using a Drude model for Ag and previous experimentally determined equations for Si (the behavior of the optical constants for crystalline Si and doped Si are found to have very little deviation between each other
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Kegel, Laurel L. "Characterization of surface plasmon resonance (SPR) active nanohole array sensing platforms| Development and application of novel instrumentation and methodology." Thesis, University of Delaware, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3701123.

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<p> Surface plasmon resonance (SPR) active nanohole array substrates offer a diverse biosensing platform with high sensitivity and unique characteristics. This dissertation investigates the sensitivity and fundamental SP features of various nanohole array substrates and demonstrates higher sensitivity than conventional continuous gold platforms, tunability to specific analytes, and great enhancement of the local field intensity. Novel instrumentation and analytical techniques are developed and utilized to assess the nanohole array SPR sensing substrates in the near infrared as well as with int
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Zheng, Rui. "The Development of an Aptamer-based Surface Plasmon Resonance (SPR) Sensor for the Real-time Detection of Glycated Protein." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1352917255.

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Bergström, Anna. "SPR Sensor Surfaces based on Self-Assembled Monolayers." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16664.

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<p>The study and understanding of molecular interactions is fundamentally important in today's field of life sciences and there is a demand for well designed surfaces for biosensor applications. The biosensor has to be able to detect specific molecular interactions, while non-specific binding of other substances to the sensor surface should be kept to a minimum.                                                                                                                                                                                The objective of this master´s thesis was to design sensor s
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Béland, Rémy. "Développement d'un biocapteur couplant la résonance des plasmons de surface et la microcalorimétrie pour le suivi des interactions moléculaires à l'interface liquide/solide." Thesis, Ecully, Ecole centrale de Lyon, 2013. http://www.theses.fr/2013ECDL0040/document.

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Dans un avenir proche, les dispositifs de détection médicaux miniaturisés en temps réels (lab-on-chip) seront au centre de la révolution des méthodes de diagnostics médicaux et d’identification des processus biologiques et cela, autant au niveau clinique qu’au niveau de la recherche. Pour y arriver, il est important de développer des chimies de surface stables et spécifiques, ce qui demande une compréhension des interactions intermoléculaires à l’interface liquide/solide. Pour bien comprendre ces interactions, il est important de développer des instruments adaptés à la mesure près de l’interfa
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Brown, Peter N. "Biophysical and structural characterisation of protein-peptide interactions." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/3982.

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Proliferating cell nuclear antigen (PCNA) is an essential protein in the cell. It is involved in transcription and many types of DNA repair and replication. Homologues of this protein are found in all orders of life. The high level of conservation and essential nature of PCNA infers that it may be a potential drug target for anti-caner drugs in humans and also a potential anti-parasitic target. X-ray structures of PCNA from Homo sapiens (Hs), Schizosaccharomyces pombe (Sp) and Leishmania major (Lm) are now available and can be used as a template for structure based drug design. In this work PC
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Salazar, Soto Arnoldo. "Conception d'un imageur CMOS à colonne active pour un biocapteur optique SPR." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENT063/document.

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Cette thèse présente la conception et la mise en œuvre d'un imageur CMOS pour être utilisé dans biocapteurs intégrés basés sur Résonance Plasmonique de Surface (SPR). Tout d'abord, les conditions optimales pour la résonance plasmon dans une interface compatible CMOS / post-CMOS sont obtenus par modélisation avec COMSOL. Deuxièmement, un imageur CMOS de Colonne Actif (CMOS-ACS) du 32x32 pixels est mis en œuvre sur une technologie CMOS 0,35 um. Dans une interface d'or-eau avec une excitation de prisme, on constate que pour les prismes avec des indices de réfraction de 1,55 et 1,46, le couplage o
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Sowdamini, Nakka Sravya. "Detection of Bacterial Flora in Biological Secretions Using Antibodies Developed In Vitro and Immobilized in a Surface Plasmon Resonance System." Thesis, Linköpings universitet, Molekylär genetik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-69084.

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Identification of pathogens living in biofilms of chronic infections has been difficult with PCR, serological, biochemical and culture techniques. The study aims at the detection of bacterial pathogens in biofilms of biological secretions using SPR analysis Biacore. The antibodies were developed by isolating mononuclear lymphocytes from the blood of the patients who sustained systemic infection. The isolated lymphocytes had antibody secreting B cells (plasma cells) which were identified using flow cytometry analysis. The antibodies produced (n=4) were used to immobilize CM5 chip of Biacore to
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PINNAMANENI, POORNIMA. "BORONIC ACID MACROLIGANDS FOR GLYCOMICS APPLICATIONS." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1347558235.

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Zimmerer, Cordelia. "Entwicklung eines optischen markierungsfreien Ionenkanalsensor-Arrays." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1193247156004-79633.

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Ligandgesteuerte Ionenkanäle sind Membranproteine, die an der Weiterleitung von Reizen und an der Kommunikation zwischen Zellen beteiligt sind. Große Bedeutung besitzt die Messung der Aktivierung der Ionenkanäle beispielsweise in der Medizin (z.B. Ionenkanalerkrankungen), der Pharmazie (z.B. Medikamenten-Screening) und in der Bionanotechnologie (z.B. molekulare Schalter). In all diesen Gebieten besteht die Forderung nach hohen Probendurchsätzen bei sehr hohem Informationsgehalt. Etablierte elektrochemische Detektionsmethoden erfüllen diese Forderung nicht. Um dieses Defizit zu überwinden, wurd
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Gradwell, Sheila Elizabeth. "Self-Assembly of Pullulan Abietate on Cellulose Surfaces." Thesis, Virginia Tech, 1999. http://hdl.handle.net/10919/10095.

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Wood is a complex biocomposite that exhibits a high work of fracture, making it an ideal model for multiphase man-made materials. Typically, man-made composites demonstrate interfacial fracture at failure due to abrupt transitions between neighboring phases. This phenomenon does not occur in wood because gradual phase transitions exist between regions of cellulose, hemicellulose, and lignin and therefore adhesion between adjacent phases is increased. The formation of interphases occurs as a consequence of the self-assembly process which governs the formation of wood. If this process was unders
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Charlermroj, Ratthaphol. "Development of multiplex detection for plant pathogens using antibody array technology in a multiwell-plate format, surface plasmon resonance (SPR) and bead array technology." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600640.

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The three different platform candidates were antibody microarray, surface Plasmon resonance (SPR) and bead array. Another objective of this project was to explore other applications of these platforms, and the selected example application was to explore other applications of these platforms for hybridoma screening. Since antibodies against plant pathogens have previously been produced, characterized and used in development of the three different platforms, to examine the possibility of applying the platforms to facilitate the screening of hybrid om a, pilhogenic foodbome bacterium Listeria mon
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Hong, Koh Yiin. "Label-free plasmonic detection using nanogratings fabricated by laser interference lithography." Thesis, Plasmonics, 2017. http://hdl.handle.net/1828/7849.

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Plasmonics techniques, such as surface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS), have been widely used for chemical and biochemical sensing applications. One approach to excite surface plasmons is through the coupling of light into metallic grating nanostructures. Those grating nanostructures can be fabricated using state-of-the-art nanofabrication methods. Laser interference lithography (LIL) is one of those methods that allow the rapid fabrication of nanostructures with a high-throughput. In this thesis, LIL was combined with other microfabrication techniques, suc
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Maillart, Emmanuel. "IMAGERIE PAR RESONANCE DES PLASMONS DE SURFACE POUR L'ANALYSE SIMULTANEE DE MULTIPLES INTERACTIONS BIOMOLECULAIRES EN TEMPS REEL." Phd thesis, Université Paris Sud - Paris XI, 2004. http://tel.archives-ouvertes.fr/tel-00006480.

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Les besoins actuels grandissants pour l'analyse des interactions biomoléculaires nécessitent le développement de systèmes automatisés à forte capacité et haut débit comme la microscopie de fluorescence qui reste une méthode de prédilection. Bien que les méthodes directes (sans marquage des molécules à analyser) présentent une sensibilité plus faible que celles utilisant des marqueurs, leurs nombreux avantages (suivi en temps réel, préparation simplifiée des échantillons) sont des atouts d'importance pour l'analyse quantitative des interactions biomoléculaires. En outre, l'imagerie en résonance
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41

Voorhees, Jeffrey L. "An Examination Of The Kintetic, Structural, And Biological Effects Of Zinc On Lactogenic Cytokine Interaction With The Human Prolactin Receptor." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218141658.

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42

De, Bonnault Sandie. "Conception, fabrication et caractérisation d'un biocapteur SPR à base de guides d'ondes photoniques sur substrat de verre." Thèse, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8957.

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Résumé : Malgré le nombre croissant de capteurs dans les domaines de la chimie et la biologie, il reste encore à étudier en profondeur la complexité des interactions entre les différentes molécules présentes lors d’une détection à l’interface solide-liquide. Dans ce cadre, il est de tout intérêt de croiser différentes méthodes de détection afin d’obtenir des informations complémentaires. Le principal objectif de cette étude est de dimensionner, fabriquer et caractériser un détecteur optique intégré sur verre basé sur la résonance plasmonique de surface, destiné à terme à être combiné avec d’au
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43

Bonnault, Sandie de. "Conception, fabrication et caractérisation d'un biocapteur SPR à base de guides d'ondes photoniques sur substrat de verre." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAT040/document.

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Malgré le nombre croissant de capteurs dans les domaines de la chimie et la biologie, de nombreuses réactions n’ont pas encore été correctement identifiées et étudiées. C’est entre autres le cas des interactions intermoléculaires à l’interface liquide/solide trouvées dans les chimies de surface utilisées pour les méthodes de diagnostics médicaux et l’identification de divers processus biologiques. Afin de correctement comprendre les mécanismes en jeux, il est important de pouvoir croiser différentes méthodes de détection pour obtenir des informations complémentaires.MuLe principal objectif de
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44

Reaver, Nathan George Frederick. "Development and Characterization of Aptamers for the use in Surface Plasmon Resonance Sensors for the Detection of Glycated Blood Proteins." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1373319138.

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45

Danilov, Artem. "Design, characterisation and biosensing applications of nanoperiodic plasmonic metamaterials." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0110/document.

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Cette thèse considère de nouvelles architectures prometteuses des métamatériaux plasmoniques pour biosensing, comprenant: (I) des réseaux périodiques 2D de nanoparticules d'Au, qui peuvent supporter des résonances des réseaux de surface couplées de manière diffractive; (II) Reseaux 3D à base de cristaux plasmoniques du type d'assemblage de bois. Une étude systématique des conditions d'excitation plasmonique, des propriétés et de la sensibilité à l'environnement local dans ces géométries métamatérielles est présentée. On montre que de tels réseaux peuvent combiner une très haute sensibilité spe
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46

Norberg, Oscar. "Photochemical Ligation Techniques for Carbohydrate Biosensors and Protein Interaction Studies." Doctoral thesis, KTH, Organisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-90956.

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This thesis concerns the development of surface ligation techniques for the preparation of carbohydrate biosensors. Several methodologies were developed based on efficient photochemical insertion reactions which quickly functionalize polymeric materials, with either carbohydrates or functional groups such as alkynes or alkenes. The alkyne/alkene surfaces were then treated with carbohydrate azides or thiols and reacted under chemoselective Cu-catalyzed azide-alkyne cycloaddition (CuAAC) or photo-radical thiol-ene/yne click chemistry, thus creating a range of carbohydrate biosensor surfaces unde
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47

Calvo, Michele. "Study and manufacturing of biosensors based on plasmonic effects and built on silicon." Thesis, Lyon, 2020. http://www.theses.fr/2020LYSEI055.

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Le contexte de ce projet de doctorat celui des biocapteurs. Le but final est d’avoir un dispositif portable, composé par une partie jetable, capable de détecter des concentrations très faibles d’un analyte spécifique, à bon marché et compacte, que les médecins peuvent utiliser dans l’hôpital où chez les patients, sans avoir besoin d’un laboratoire entier. Les analytes peuvent être plusieurs (à partir de l’ADN pour la détection de maladies génétiques où des cellules cancéreuses pour la détection précoce du cancer). Cet objectif est possible seulement avec un transducteur qui arrive à convertir
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48

CAVALCANTI, Leonardo Machado. "Aplicativo web para projeto de sensores ópticos baseados em ressonância de plasmons de superífice em interfaces planares." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/18272.

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Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2017-01-30T18:17:26Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) DISSERTACAO_LEO_DEFESA - FINAL - CATALOGADA PDF.pdf: 4585329 bytes, checksum: 4b70c80127866cd2da97a6217bb6a34f (MD5)<br>Made available in DSpace on 2017-01-30T18:17:27Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) DISSERTACAO_LEO_DEFESA - FINAL - CATALOGADA PDF.pdf: 4585329 bytes, checksum: 4b70c80127866cd2da97a6217bb6a34f (MD5) Previous issue date: 2016-08-16<
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Segervald, Jonas. "Fabrication and Optimization of a Nanoplasmonic Chip for Diagnostics." Thesis, Umeå universitet, Institutionen för fysik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-163998.

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To increase the survival rate from infectious- and noncommunicable diseases, reliable diagnostic during the preliminary stages of a disease onset is of vital importance. This is not trivial to achieve, a highly sensitive and selective detection system is needed for measuring the low concentrations of biomarkers available. One possible route to achieve this is through biosensing based on plasmonic nanostructures, which during the last decade have demonstrated impressive diagnostic capabilities. These nanoplasmonic surfaces have the ability to significantly enhance fluorescence- and Raman signal
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50

Geiss, Frank Andreas [Verfasser]. "Proteo-Lipobeads : a novel platform to investigate strictly oriented membrane proteins in their functionally active form. Bio-UV-SPR: exploring the ultraviolet spectral range for water-bound analytes in surface plasmon resonance spectroscopy / Frank Andreas Geiss." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1175027928/34.

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