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1
Kulkarni, Samar, Ray Powles, Jennie Treleaven, et al. "Chronic graft versus host disease is associated with long-term risk for pneumococcal infections in recipients of bone marrow transplants." Blood 95, no. 12 (2000): 3683–86. http://dx.doi.org/10.1182/blood.v95.12.3683.
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Abstract Incidences of and risk factors for Streptococcus pneumoniaesepsis (SPS) after hematopoietic stem cell transplantation were analyzed in 1329 patients treated at a single center between 1973 and 1997. SPS developed in 31 patients a median of 10 months after transplantation (range, 3 to 187 months). The infection was fatal in 7 patients. The probability of SPS developing at 5 and 10 years was 4% and 6%, respectively. Age, sex, diagnosis, and graft versus host disease (GVHD) prophylaxis did not influence the development of SPS. Allogeneic transplantation (10-year probability, 7% vs 3% for nonallogeneic transplants; P = .03) and chronic GVHD (10-year probability, 14% vs 4%; P = .002) were associated with significantly higher risk for SPS. All the episodes of SPS were seen in patients who had undergone allograft or total body irradiation (TBI) (31 of 1202 vs 0 of 127;P = .07). Eight patients were taking regular penicillin prophylaxis at the time of SPS, whereas 23 were not taking any prophylaxis. None of the 7 patients with fatal infections was taking prophylaxis for Pneumococcus. Pneumococcal bacteremia was associated with higher incidences of mortality (6 of 15 vs 1 of 16;P = .04). We conclude that there is a significant long-term risk for pneumococcal infection in patients who have undergone allograft transplantation, especially those with chronic GVHD. Patients who have undergone autograft transplantation after TBI-containing regimens also appear to be at increased risk. These patients should receive lifelong pneumococcus prophylaxis. Consistent with increasing resistance to penicillin, penicillin prophylaxis does not universally prevent SPS, though it may protect against fatal infections. Further studies are required to determine the optimum prophylactic strategy in patients at risk.
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Kulkarni, Samar, Ray Powles, Jennie Treleaven, et al. "Chronic graft versus host disease is associated with long-term risk for pneumococcal infections in recipients of bone marrow transplants." Blood 95, no. 12 (2000): 3683–86. http://dx.doi.org/10.1182/blood.v95.12.3683.012k19_3683_3686.
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Incidences of and risk factors for Streptococcus pneumoniaesepsis (SPS) after hematopoietic stem cell transplantation were analyzed in 1329 patients treated at a single center between 1973 and 1997. SPS developed in 31 patients a median of 10 months after transplantation (range, 3 to 187 months). The infection was fatal in 7 patients. The probability of SPS developing at 5 and 10 years was 4% and 6%, respectively. Age, sex, diagnosis, and graft versus host disease (GVHD) prophylaxis did not influence the development of SPS. Allogeneic transplantation (10-year probability, 7% vs 3% for nonallogeneic transplants; P = .03) and chronic GVHD (10-year probability, 14% vs 4%; P = .002) were associated with significantly higher risk for SPS. All the episodes of SPS were seen in patients who had undergone allograft or total body irradiation (TBI) (31 of 1202 vs 0 of 127;P = .07). Eight patients were taking regular penicillin prophylaxis at the time of SPS, whereas 23 were not taking any prophylaxis. None of the 7 patients with fatal infections was taking prophylaxis for Pneumococcus. Pneumococcal bacteremia was associated with higher incidences of mortality (6 of 15 vs 1 of 16;P = .04). We conclude that there is a significant long-term risk for pneumococcal infection in patients who have undergone allograft transplantation, especially those with chronic GVHD. Patients who have undergone autograft transplantation after TBI-containing regimens also appear to be at increased risk. These patients should receive lifelong pneumococcus prophylaxis. Consistent with increasing resistance to penicillin, penicillin prophylaxis does not universally prevent SPS, though it may protect against fatal infections. Further studies are required to determine the optimum prophylactic strategy in patients at risk.
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Wright, A., R. Ma, T. Hummer, et al. "SU-F-SPS-07: Magnetic Resonance Spectroscopy Findings in Early-Phase Psychosis." Medical Physics 43, no. 6Part4 (2016): 3351. http://dx.doi.org/10.1118/1.4955682.
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Serpell, Benjamin G., Joshua Strahorn, Carmen Colomer, Andrew McKune, Christian Cook, and Kate Pumpa. "The Effect of Speed, Power, and Strength Training and a Group Motivational Presentation on Physiological Markers of Athlete Readiness: A Case Study in Professional Rugby." International Journal of Sports Physiology and Performance 14, no. 1 (2019): 125–29. http://dx.doi.org/10.1123/ijspp.2018-0177.
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Objective: To examine the effect of a physical treatment (speed, power, and strength [SPS] training) and psychosocial treatment (group motivational presentation) on salivary testosterone (sal-T), salivary cortisol (sal-C), and sal-T-to-sal-C ratio (T:C) in professional rugby. Methods: Fourteen male rugby players (age = 25.9 [2.5] y, height = 186.1 [6.7] cm, and body mass = 104.1 [12.7] kg) participated in this study. Testing occurred across 2 d on 2 separate occasions (week 1 and week 2). On day 1 of both weeks, participants completed an SPS training session. On day 2 of both weeks, participants undertook a field-based rugby training session. In week 2, participants underwent an additional treatment in the form of a motivational presentation given by a respected former player before the rugby session. Saliva was collected before and after SPS training and before and after the rugby session and was assayed for testosterone and cortisol. Results: No differences were found between weeks for sal-T at any time point, but sal-C was higher in week 2 before and after SPS and before rugby on day 2 (P < .05). In both weeks, T:C increased following SPS (P < .02, ES > 0.91 [0.13, 1.69]). T:C increased when the motivational presentation accompanied rugby training (P = .07, ES = 1.06 [0.27, 1.85]). Sal-C, not sal-T, drove changes in T:C (P < .001). Conclusions: Physical or psychosocial treatments may affect sal-T, sal-C, and T:C, and individual variation in responses to treatments may exist.
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VERMA*, M. K., V. K. SHARMA, SHIV LAL, et al. "Quality profiling of Indian walnut (Juglans regia) from Kashmir valley." Indian Journal of Agricultural Sciences 90, no. 3 (2020): 573–76. http://dx.doi.org/10.56093/ijas.v90i3.101478.
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The aim of this study was to know the nutritional composition of walnuts grown in Kashmir valley of north western Himalayan region for their commercial exploit at farm and consumer level. Samples were collected from earmarked trees growing in major walnut producing areas of Kashmir valley. The research work was conducted during 2002-18 at ICAR-CITH, Srinagar. The observations were assessed in 11 walnut (Juglans regia L.) genotypes (BHU-01, ZC- 05, NU-03, SPS-02, BPP-05, MPU-04, NU-05, CSB-02, DU-07, NU-02 and BPP-07). Mineral content: zinc (Zn), magnesium (Mg), manganese (Mn), selenium (Se), copper (Cu), aluminium (Al), cobalt (Co), molybdenum (Mo), and iron (Fe), were determined by atomic absorption spectrophotometry. Fat content was determined by standard Association of Official Analytical Chemists (AOAC) methods. Nut and kernel exterior quality traits were recorded as per the IBPGR descriptor. Results revealed that micro-mineral nutrient contents expressed in mg/100 g dry weight ranged between 147.39-68.07 (Mg), 19.71-74.16 (Mo), 7.32-15.57 (Mn), 2.25-9.03 (Cu), 2.90-3.53 (Zn), 1.99-3.81 (Fe), 0.11-0.93 (Al), 0.007-0.069 (Co) and 0.00-0.006 (Se). The fats accounted for more than 60% of the walnut kernel weight and it was ranged from 53.54-74.93%. Significant variability (P<0.05) recorded for physical properties can be attributed to quality criteria of nuts and kernel in walnut.
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Liu, Zhengchang, Janet Thornton, Mário Spírek, and Ronald A. Butow. "Activation of the SPS Amino Acid-Sensing Pathway in Saccharomyces cerevisiae Correlates with the Phosphorylation State of a Sensor Component, Ptr3." Molecular and Cellular Biology 28, no. 2 (2007): 551–63. http://dx.doi.org/10.1128/mcb.00929-07.
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ABSTRACT Cells of the budding yeast Saccharomyces cerevisiae sense extracellular amino acids and activate expression of amino acid permeases through the SPS-sensing pathway, which consists of Ssy1, an amino acid sensor on the plasma membrane, and two downstream factors, Ptr3 and Ssy5. Upon activation of SPS signaling, two transcription factors, Stp1 and Stp2, undergo Ssy5-dependent proteolytic processing that enables their nuclear translocation. Here we show that Ptr3 is a phosphoprotein whose hyperphosphorylation is increased by external amino acids and is dependent on Ssy1 but not on Ssy5. A deletion mutation in GRR1, encoding a component of the SCFGrr1 E3 ubiquitin ligase, blocks amino acid-induced hyperphosphorylation of Ptr3. We found that two casein kinase I (CKI) proteins, Yck1 and Yck2, previously identified as positive regulators of SPS signaling, are required for hyperphosphorylation of Ptr3. Loss- and gain-of-function mutations in PTR3 result in decreased and increased Ptr3 hyperphosporylation, respectively. We found that a defect in PP2A phosphatase activity leads to the hyperphosphorylation of Ptr3 and constitutive activation of SPS signaling. Two-hybrid analysis revealed interactions between the N-terminal signal transduction domain of Ssy1 with Ptr3 and Yck1. Our findings reveal that CKI and PP2A phosphatase play antagonistic roles in SPS sensing by regulating Ptr3 phosphorylation.
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Gafirimbi, Naasson, Rex Wong, Eva Adomako, and Jeanne Kagwiza. "Lessons learned in establishing a quality improvement project to reduce hospital acquired infections in the neonatology ward at a referral hospital in Rwanda." On the Horizon 24, no. 4 (2016): 341–48. http://dx.doi.org/10.1108/oth-07-2016-0037.
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Purpose Improving healthcare quality has become a worldwide effort. Strategic problem solving (SPS) is one approach to improve quality in healthcare settings. This case study aims to illustrate the process of applying the SPS approach in implementing a quality improvement project in a referral hospital. Design/methodology/approach A project team was formed to reduce the hospital-acquired infection (HAI) rate in the neonatology unit. A new injection policy was implemented according to the root cause identified. Findings The HAI rate decreased from 6.4 per cent pre-intervention to 4.2 per cent post-intervention. The compliance of performing the aseptic injection technique significantly improved by 60 per cent. Practical implications This case study illustrated the detailed application of the SPS approach in establishing a quality improvement project to address HAI and injection technique compliance, cost-effectively. Other departments or hospitals can apply the same approach to improve quality of care. Originality/value This study helps inform other hospitals in similar settings, the steps to create a quality improvement project using the SPS approach.
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Bahufite, Augustin, Albert Ndagijimana, Eva Adomako, et al. "Implementing wound dressing protocol to reduce post cesarean section surgical site infections in Mibilizi District Hospital, Rwanda." On the Horizon 24, no. 4 (2016): 369–76. http://dx.doi.org/10.1108/oth-07-2016-0042.
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Purpose Caesarean section (CS) is one of the most common surgeries in the world. Although the procedure saves lives, it poses important risks such as post-caesarean surgical site infection (PCS-SSI). Basic patient care procedures can prevent PCS-SSI, however, they are not always followed. The purpose of this study is to describe how strategic problem solving (SPS) was used to implement a wound dressing protocol in a district hospital in Rwanda to reduce PCS-SSI rates. Design/methodology/approach To address variations in wound care practice, a new clinical protocol was developed and implemented by a quality improvement team which included clinicians. Training and supervision was also provided to the maternity team. Findings The intervention reduced PCS-SSI from 5.1 to 1.8 per cent. It also significantly improved the compliance to recommended wound dressing practices. Practical implications By applying SPS and effective leadership skills, the authors secured buy-in and support from stakeholders and introduced a wound management protocol in a district hospital of Rwanda. The intervention significantly improved wound management practice; however, long term follow-up will be necessary to sustain the improvements. Originality/value The results will inform hospitals in resource-limited settings of how to improve basic standards of care using SPS and leadership without additional cost to the hospital.
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Cicero, V. "The SHADOWS experiment at the CERN SPS." Journal of Instrumentation 19, no. 07 (2024): C07012. http://dx.doi.org/10.1088/1748-0221/19/07/c07012.
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Abstract SHADOWS (Search for Hidden And Dark Objects With the SPS) is a proposed proton beam-dump experiment for the search of a large variety of Feebly-Interacting Particles (FIPs) at the CERN SPS. It will exploit the potential for searches and discoveries at the intensity frontier offered by the upgrade of the ECN3 beam line. SHADOWS will be located off-axis, which allows the optimisation of the signal-to-background ratio, and will collect data from up to 5×1019 protons of 400 GeV on target in 4 years of operations. The experiment has a transversal size of 2.5×2.5 m2 and is composed by an upstream veto, a 20 m long decay volume and a spectrometer with a tracking system in a dipole magnet, a timing detector, a calorimeter and a muon system. The conceived detector offers excellent tracking and timing performance for the identification and reconstruction of most of the visible final states of FIP decays. SHADOWS will allow to explore a large parameter space region of many FIPs, like light dark scalars, axion-like particles and heavy neutral leptons, with masses ranging between 0.1 and 10 GeV. This paper reports about the status of the proposal of the SHADOWS experiment, with focus on the detector challenges.
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Schiavone, Francesco, Antonio Meles, Vincenzo Verdoliva, and Manlio Del Giudice. "Does location in a science park really matter for firms’ intellectual capital performance?" Journal of Intellectual Capital 15, no. 4 (2014): 497–515. http://dx.doi.org/10.1108/jic-07-2014-0082.
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Purpose – The purpose of this paper is to investigate the effect of being located in a science park (SP) on the level of a firm's intellectual capital (IC) performance. Design/methodology/approach – Using a sample of 183 Italian firms (i.e. 61 tenant and 122 non-tenant firms), and through the GLS technique, the authors regress the firms’ IC performance across various explicative variables including a dummy that discriminates tenant and non-tenant firms. Findings – Consistently with expectations, the results show that the location of a firm in a SP leads to improved IC performance. Moreover, the authors find that some other firm characteristics, such as size, age, and leverage, are important predictors of its IC-based performance. Research limitations/implications – The sample is small and the impact on performance might be biased by factors related to the regional context (e.g. level of industrialization, quality of education, and science system). Practical implications – Implications for policy makers: support the growth of firms in SPs especially in those industries full of firms with scarce performance in IC. Implications for SP managers: they could “sell” (in terms of marketing) to both entrepreneurs to attract and policy makers this result. Implications for institutional investors: they should look at SPs with greater interest to find high-quality firms and improve their screening activity. Originality/value – This paper aims to extend literature about factors explaining the level of a firm's IC performance and the current understanding of the impact of SPs at firm level.
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Boumediene, D., A. Pingault, M. Tytgat, et al. "Energy reconstruction of hadronic showers at the CERN PS and SPS using the Semi-Digital Hadronic Calorimeter." Journal of Instrumentation 17, no. 07 (2022): P07017. http://dx.doi.org/10.1088/1748-0221/17/07/p07017.
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Abstract The CALICE Semi-Digital Hadronic CALorimeter (SDHCAL) is the first technological prototype in a family of high-granularity calorimeters developed by the CALICE Collaboration to equip the experiments of future lepton colliders. The SDHCAL is a sampling calorimeter using stainless steel for absorber and Glass Resistive Plate Chambers (GRPC) as a sensitive medium. The GRPC are read out by 1 cm× 1 cm pickup pads combined to a multi-electronics. The prototype was exposed to hadron beams in both the CERN PS and the SPS beamlines in 2015 allowing the test of the SDHCAL in a large energy range from 3 GeV to 80 GeV. After introducing the method used to select the hadrons of our data and reject the muon and electron contamination, we present the energy reconstruction approach that we apply to the data collected from both beamlines and we discuss the response linearity and the energy resolution of the SDHCAL. The results obtained in the two beamlines confirm the excellent SDHCAL performance observed with the data collected with the same prototype in the SPS beamline in 2012. They also show the stability of the SDHCAL in different beam conditions and different time periods.
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Mingsheng, He, Li Jianbao, Lin Hong, Guo Gangfeng, and Liang Long. "Fabrication of Transparent Polycrystalline Yttria Ceramics by Combination of SPS and HIP." Journal of Rare Earths 24, no. 1 (2006): 222–24. http://dx.doi.org/10.1016/s1002-0721(07)60365-2.
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Woods, Arthur, Andreas Vogler, and Patrick Collins. "The Lunar Space Elevator: A Key Technology for Realising the Greater Earth Lunar Power Station (GEO-LPS)." Journal of the British Interplanetary Society 76, no. 7 (2023): 252–62. http://dx.doi.org/10.59332/jbis-076-07-0252.
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The Greater Earth Lunar Power Station (GE -LPS) is a multi-purpose concept that aims to solve several critical issues related to lunar development and terrestrial energy production. As the GE -LPS concept and its energy production functions may be scaled to any dimension, larger versions could be positioned in Earth orbit to provide clean solar energy for terrestrial purposes and thereby reduce the mass needed to be launched from Earth to build SPS units by 80% or more. The construction of the GE -LPS from mostly lunar materials requires the establishment of industrial-scale automated mining and manufacturing processes on the Moon. A key technology is a Lunar Space Elevator (LSE) deployed as a transportation system to move SPS components from an anchor point on the surface of the Moon to a docking and assembly station at Earth-Moon Lagrange point 1 (EM-L1). Significantly, a LSE could be built today with existing tether materials such as Dyneema or Zylon which are already commercially available. Additionally, lunar sourced basalt fibre may be sufficient for reinforcing and extending the LSE once it becomes operational. An Earth-pointing LSE could become a valuable cislunar infrastructure asset – “the Suez Canal of cislunar space” – linking the Earth and Moon economies. Note: The ‘O’ symbol is an ancient European symbol for planet Earth: it is used here to mean “Greater Earth”, a region defined by the Earth’s gravitational field, which includes the Moon. Keywords: Solar Power Satellite, Lunar ISRU, Lunar Space Elevator, Energy, Europe
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Labunskaya, V. A., and E. V. Kapitanova. "Self-Assessment and Appearance Evaluation in Student Group as Predictors in Relationships of Interpersonal Significance." Social Psychology and Society 7, no. 1 (2016): 72–87. http://dx.doi.org/10.17759/sps.2016070106.
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The paper attempts to integrate the concept of relationships of interpersonal significance, approaches to the correlation between physical appearance and life satisfaction, as well as several concepts of interpersonal cognition, self-assessment and evaluations of other people’s physical appearance. It introduces the concept of “insignificant/significant assessor of appearance” and argues that among the factors that turn a group member into the “insignificant/significant assessor of appearance” are evaluations, self-evaluations and group evaluations of physical appearance. The research described in the paper involved 89 students aged 19—21 (M=20 years), 66 females and 23 males, members of five groups that have been studying together for three years. The methods employed in the study included: “The Evaluation/Content Interpretation of Appearance and its Correspondence with Gender/Age Constructs”, a technique developed by V.A. Labunskaya; a modification of a sociometric test that helped reveal “insignificant/significant assessors of appearance”. Also, nonparametric mathematical methods were used to carry out comparative analysis. The outcomes show that there are considerable differences between the self-assessments, evaluations of physical appearance of those group members who are “significant assessors of appearance”, and group evaluations of their appearance. The research was conducted with the assistance of the Southern Federal University (project № 213.01-07-2014/15ПЧВГ “Threats to National Security in Situations of Geopolitical Competition and Models of Aggressive and Hostile Behavior in Children and Youth in Southern Russia” – project part of the inner grant of the Southern Federal University).
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Khan, Shaheen, Fei Wu, Shengxi Liu, Qian Wu, and Stephen Safe. "Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells." Journal of Molecular Endocrinology 39, no. 4 (2007): 289–304. http://dx.doi.org/10.1677/jme-07-0043.
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AbstractDeletion analysis of several 17β-estradiol (E2)-responsive genes have identified GC-rich sites that are associated with hormone-induced transactivation in MCF-7 breast cancer cells. However, the role of individual specificity proteins (Sps) in mediating hormone-induced gene expression has not been unequivocally determined. In transient transfection studies using E2-responsive GC-rich promoters from the E2F1, carbamoylphosphate synthetase/aspartate transcarbamylase/dihydroorotase (CAD), and retinoic acid receptor α (RARα) genes, RNA interference using small inhibitory RNAs for Sp1 (iSp1), Sp3 (iSp3), and Sp4 (iSp4) decreased both basal and E2-induced transactivation. The contributions of individual Sp proteins to basal and E2-induced activity were promoter dependent. iSp1, iSp3, and iSp4 also significantly inhibited hormonal induction of E2F1, CAD, and RARα mRNA levels; however, the enhanced inhibitory effects of the latter two small inhibitory RNAs suggest that Sp3 and Sp4 play a major role in estrogen receptor α/Sp-mediated gene expression in MCF-7 cells.
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Adriani, O., E. Berti, P. Betti, et al. "High-resolution, high-dynamic-range charge detector for ion beam monitoring." Journal of Instrumentation 20, no. 07 (2025): C07046. https://doi.org/10.1088/1748-0221/20/07/c07046.
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Abstract We present the second-generation charge detector, designed to further improve resolution, dynamic range, and robustness for high-energy ion beam monitoring. This upgraded prototype incorporates enhanced silicon photodiodes, a refined front-end electronics design, and optimized mechanical construction to improve noise performance and operational stability. Extensive testing during HERD and AMS beam campaigns at CERN SPS demonstrated significant performance gains over the first version, achieving superior charge resolution and maintaining a dynamic range capable of accurately measuring nuclei from Z=1 up to Z≈80. The detector's fast, real-time data analysis capabilities have also been strengthened, confirming its suitability for online monitoring applications. In this article, we summarize the new developments, present updated test results, and outline future improvements, including adaptations for broader applications in beam monitoring, nuclear cross-section measurements, and cosmic-ray studies.
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Beresford, L. A., D. E. Boumediene, L. Castillo García, et al. "Destructive breakdown studies of irradiated LGADs at beam tests for the ATLAS HGTD." Journal of Instrumentation 18, no. 07 (2023): P07030. http://dx.doi.org/10.1088/1748-0221/18/07/p07030.
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Abstract In the past years, it has been observed at several beam test campaigns that irradiated LGAD sensors break with a typical star shaped burn mark when operated at voltages much lower than those at which they were safely operated during laboratory tests. The study presented in this paper was designed to determine the safe operating voltage that these sensors can withstand. Many irradiated sensors from various producers were tested in two test beam facilities, DESY (Hamburg) and CERN-SPS (Geneva), as part of ATLAS High Granularity Timing Detector (HGTD) beam tests. The samples were placed in the beam and kept under bias over a long period of time in order to reach a high number of particles crossing each sensor. Both beam tests lead to a similar conclusion, that these destructive events begin to occur when the average electric field in the sensor becomes larger than 12 V/μm.
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Nyiratuza, Adeline, Rex Wong, Eva Adomako, et al. "A quality improvement project to improve the accuracy in reporting hospital acquired infections in post cesarean section patients in a district hospital in Rwanda." On the Horizon 24, no. 4 (2016): 319–26. http://dx.doi.org/10.1108/oth-07-2016-0035.
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Purpose Hospitals are responsible for protecting the well-being of their patients and staff. To do so, accurate information is needed for the hospital to make appropriate decisions and allocate resources efficiently. This study aims to describe the implementation process of a surveillance system to reduce hospital-acquired infection (HAI) reporting errors in the maternity unit of a district hospital in Rwanda. Design/methodology/approach The team adapted an evidence-based tool to identify and report HAI, provided training to staff and distributed reporting responsibilities equally between the maternity staff to improve accuracy in HAI reporting. Findings The intervention successfully reduced the reporting discrepancy of HAI from 6.5 to 1.9 per cent: p < 0.05. Practical implications This case study described the implementation process of a surveillance system using strategic problem solving to reduce HAI reporting errors. The results can inform hospitals in similar settings of the steps to follow to implement a cost-neutral HAI surveillance system to reduce reporting errors. The accurate data will enable the hospital to take corrective measures to address HAI in the future. Originality/value The results will inform hospitals in similar settings of steps to follow to implement a cost-neutral HAI surveillance system using the SPS approach to reduce reporting errors.
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Lisowska, M., Y. Angelis, S. Aune, et al. "Towards robust PICOSEC Micromegas precise timing detectors." Journal of Instrumentation 18, no. 07 (2023): C07018. http://dx.doi.org/10.1088/1748-0221/18/07/c07018.
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Abstract The PICOSEC Micromegas (MM) detector is a precise timing gaseous detector consisting of a Cherenkov radiator combined with a photocathode and a MM amplifying structure. A 100-channel PICOSEC MM prototype with 10 × 10 cm2 active area equipped with a Cesium Iodide (CsI) photocathode demonstrated a time resolution below σ = 18 ps. The objective of this work is to improve the PICOSEC MM detector robustness aspects, i.e. integration of resistive MM and carbon-based photocathodes, while maintaining good time resolution. The PICOSEC MM prototypes have been tested in laboratory conditions and successfully characterised with 150 GeV/c muon beams at the CERN SPS H4 beam line. The excellent timing performance below σ = 20 ps for an individual pad obtained with the 10 × 10 cm2 area resistive PICOSEC MM of 20 MΩ/□ showed no significant time resolution degradation as a result of adding a resistive layer. A single-pad prototype equipped with a 12 nm thick Boron Carbide (B4C) photocathode presented a time resolution below σ = 35 ps, opening up new possibilities for detectors with robust photocathodes. The results made the concept more suitable for the experiments in need of robust detectors with good time resolution.
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Gargano, F., N. M. Aprile Ximenes, F. C. T. Barbato, et al. "The Plastic Scintillator Detector for the future High Energy cosmic-Radiation Detection facility on board the Chinese Space Station." Journal of Instrumentation 20, no. 07 (2025): C07014. https://doi.org/10.1088/1748-0221/20/07/c07014.
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Abstract The High Energy cosmic-Radiation Detection (HERD) facility, that will be installed on board the Chinese Space Station, is expected to make significant advancements in cosmic-ray observations, dark matter searches, and gamma-ray astronomy, thanks to its innovative design. The HERD geometry is based on a 3-dimensional imaging calorimeter, which is surrounded on five sides by a fiber tracker, a plastic scintillator detector (PSD), and a silicon charge detector. This unique configuration enables HERD to address key questions in high-energy astrophysics with unprecedented sensitivity and resolution. The PSD will be used as an anti-coincidence system for precise gamma-ray detection (charged particle veto) and charged cosmic-ray nuclei identification. In order to achieve high performance in terms of detection efficiency and charge resolution, the PSD requires a highly segmented geometry, as well as the optimization of the light sensors and electronic read-out. The current design consists of long trapezoidal scintillator tiles coupled to Silicon Photomultipliers (SiPMs). Different prototypes have been built and tested at CERN, Switzerland, and at the CNAO (Centro Nazionale di Adroterapia Oncologica) facility in Italy to study and improve the performance of the PSD. In this contribution, we present the overall project design and the PSD preliminary performances achieved during the beam test campaign at CERN SPS, with a focus on the nuclei identification capability.
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Chia, Yong Hwa, Ivan CK Tam, and Arun Kr Dev. "Impact of Maritime Labour Convention on design of new ships." Maritime Business Review 2, no. 4 (2017): 376–88. http://dx.doi.org/10.1108/mabr-07-2017-0022.
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Purpose The Maritime Labour Convention (MLC) embodies standards of existing international maritime labour conventions and recommendations, as well as the fundamental principles to be found in other international labour conventions. The aim of the convention is to address the employment standards of seafarers in the areas of fair wages, contractual terms, working and living conditions, as well as their health and safety on board ships. The purpose of this paper is to provide an in-depth study of MLC Regulation 3.1, specifically on the layout design of the accommodation spaces and possible solutions to meet the new demands as those will certainly affect the crew comfort, health and well-being on board ships. Design/methodology/approach The approach used includes a review of pre- and post-MLC conventions and regulations. This is then followed by looking at the impact of MLC Regulation 3.1 on new ship design. Possible solutions for new ship design are then proposed. Findings The findings from the paper were as follows: More flexibility in the form of non-mandatory guidelines and substantial equivalence under MLC. Under MLC, only Special Purpose Ship (SPS) is allowed to accommodate four persons in one room. The requirement for increased height and floor spaces would result in increased gross register tons (GT) for post-MLC built vessels. Impact due to post-MLC requirements would be more unfavourable for the design of smaller vessels below 500 GT than of bigger vessels of up to less than 3,000 GT. Possible solutions include applying for exemptions and substantial equivalents with flag states or registering with a non-ratifying flag state. Originality/value This paper has been based on a dissertation carried out for the partial fulfilment of a post-graduate degree. It has not been published in any journal.
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Aehle, M., J. Alme, C. Arata, et al. "Performance of the electromagnetic and hadronic prototype segments of the ALICE Forward Calorimeter." Journal of Instrumentation 19, no. 07 (2024): P07006. http://dx.doi.org/10.1088/1748-0221/19/07/p07006.
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Abstract We present the performance of a full-length prototype of the ALICE Forward Calorimeter (FoCal). The detector is composed of a silicon-tungsten electromagnetic sampling calorimeter with longitudinal and transverse segmentation (FoCal-E) of about 20X 0 and a hadronic copper-scintillating-fiber calorimeter (FoCal-H) of about 5λ int. The data were taken in various test beam campaigns between 2021 and 2023 at the CERN PS and SPS beam lines with hadron beams up to energies of 350 GeV, and electron beams up to 300 GeV. Regarding FoCal-E, we report a comprehensive analysis of its response to minimum ionizing particles across all pad layers, employing various operational modes including different pre-amplifier and bias voltage settings. The longitudinal shower profile of electromagnetic showers is measured with a layer-wise segmentation of 1X 0. As a projection to the performance of the final detector in electromagnetic showers, we demonstrate linearity in the full energy range, and show that the energy resolution fulfills the requirements for the physics needs. Additionally, the performance to separate two-showers events was studied by quantifying the transverse shower width. Regarding FoCal-H, we report a detailed analysis of the response to hadron beams between 60 and 350 GeV. The results are compared to simulations obtained with a Geant4 model of the test beam setup, which in particular for FoCal-E are in good agreement with the data. The energy resolution of FoCal-E was found to be lower than 3% at energies larger than 100 GeV. The response of FoCal-H to hadron beams was found to be linear, albeit with a significant intercept that is about factor 2 larger than in simulations. Its resolution, which is non-Gaussian and generally larger than in simulations, was quantified using the FWHM, and decreases from about 16% at 100 GeV to about 11% at 350 GeV. The discrepancy to simulations, which is particularly evident at low hadron energies, needs to be further investigated.
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Stenmark, Cheryl K. "Transformational and transactional leadership behaviors and ethical perceptions: the effects of sensory processing sensitivity." Journal of Management Development, November 10, 2023. http://dx.doi.org/10.1108/jmd-07-2023-0206.
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PurposeSensory processing sensitivity (SPS) is a trait that affects people's thinking and behavior. People who are higher in SPS are more sensitive to internal and environmental stimuli. The present study examined the effects of transformational and transactional leadership behaviors on follower ethical cognition and perception and the role that follower SPS plays in that process.Design/methodology/approachParticipants read vignettes in which their leader was described as transformational or transactional. Participants then qualitatively answered a series of four emails asking questions about an ethical problem. Then they completed measures of ethical perceptions and SPS. Qualitative data were content coded to evaluate ethical cognition.FindingsResults indicated that people higher in SPS had lower ethical perceptions than people lower in SPS when their leader was transactional. However, when their leader was transformational, people higher in SPS had higher ethical perceptions than people lower in SPS. Results suggest that a match between a follower's SPS and a leader's behaviors can influence followers' ethical perceptions. Findings suggest that organizational leader and management development interventions should encourage leaders to use transformational behaviors to improve followers' ethical perceptions.Originality/valuePrevious research has examined the effects of transformational and transactional leadership on many outcomes for followers, including ethical attitudes and behaviors. The present study contributes to this literature by examining the effects of transformational and transactional leadership behaviors on ethical cognition and perceptions.
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"Ablaufsteuerungen ohne Programmierkenntnisse erstellen." Konstruktion 76, no. 06-07 (2024): 22–24. http://dx.doi.org/10.37544/0720-5953-2024-06-07-22.
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Ablaufsteuerungen für industrielle Anwendungen werden oft noch mit Speicherprogrammierbaren Steuerungen (SPS) oder unflexiblen Einzelreglern programmiert. Ein Multifunktions-controller kann diese Lücke zwischen einer SPS und einfachen Reglern schließen. Mit einer ergänzenden Software haben Anwender außerdem die Möglichkeit sowohl Ablaufsteuerungen, als auch Prozess- und Programmabläufe, benutzerdefinierte Bedienseiten und Applikationen zu erstellen – ganz ohne Programmierkenntnisse.
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Seth, Neha, Monica Singhania, and Saif Siddiqui. "Modeling returns of sukuk and related indices with system GMM: evidence from the MENA region." International Journal of Islamic and Middle Eastern Finance and Management, October 27, 2021. http://dx.doi.org/10.1108/imefm-07-2018-0222.
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Purpose The paper aims to resolve the ongoing issue of asset pricing in indexed based investments, primarily in Sukuks. It is to be done by modeling the returns of S&P MENA (Middle East and North Africa) Sukuk index (SPS), S&P MENA bonds indices (SPM) and Dow Jones MENA (DJM) equity index using system equations and to find out cointegration among them. Design/methodology/approach In this study, daily data of stated regional market indices, from the month July 2013 to June 2017, are analyzed using the cointegration model and Generalized Method of Moments (GMM) estimation. Findings Findings revealed through cointegration test that indices are found to be not integrated in the long run; however, in short run, DJM is having one way relation with other two indices, and SPM and SPS are having unidirectional relation. The results of the GMM model show that SPS is significant in influencing SPM and vice-versa, and rest other variables are insignificant in influencing each other systems equations. Originality/value There is ample work available on various Islamic indices, but there is no study found on the MENA (Middle East and North Africa) Equity, MENA Bond and MENA Sukuk indices together.
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"SPS-Programme mit vereinfachtem digitalem Zwilling testen." Konstruktion 74, no. 07-08 (2022): 30–33. http://dx.doi.org/10.37544/0720-5953-2022-07-08-30.
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Nach Fertigstellung eines SPS-Programms muss dieses möglichst genau auf logische Fehler geprüft werden, um die Zeit für die Inbetriebnahme zu verkürzen und um gefährliche Situationen zu vermeiden. Ohne die Sensorsignale der Hardware ist dies aber oft schwer oder gar nicht möglich. Hier setzt die Prozess-Simulation PLC-Lab an. Mit ihr schafft sich der SPS-Programmierer seine virtuelle Testumgebung, um sein Programm hinreichend genau testen zu können. Ein Beispiel zeigt, wie das in der Praxis funktioniert.
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Couret, Alain, Guy Molénat, Jean Galy, and Marc Thomas. "Effect of SPS processing temperature on the microstructure and properties of a Ti49Al47Cr2Nb2 alloy." MRS Proceedings 980 (2006). http://dx.doi.org/10.1557/proc-980-0980-ii07-07.
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AbstractThe sintering of TiAl alloys by the Spar Plasma Sintering (SPS) technique is investigated in the present paper. Compactions are conducted between 1100°C and 1225°C on a Ti49Al47Cr2Nb2 powder. Single phased and lamellar microstructures are generated at low and high temperatures, respectively. The former exhibits enhanced tensile properties at room temperature but at the expense of a limited creep resistance. On the other hand, the latter suffers from a poor ductility.The deformation systems which are activated are determined by post-mortem transmission electron microscopy. The behavior of the single phased-alloy is analyzed in terms of the Hall-Petch law.
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Ashour Bakri, Abdulhadi, E. Zhilyakova, Ghadeer Balloul, Abdullah Yahya Yousif, and A. Taran. "IDENTIFICATION AND QUANTITATION OF FEXOFENADINE HYDROCHLORIDE IN MODEL ORAL DROPS." Problems of Biological, Medical and Pharmaceutical Chemistry, July 11, 2023, 40–45. http://dx.doi.org/10.29296/25877313-2023-07-06.
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Relevance. Fexofenadine hydrochloride is a representative of the III generation of histamine H1 receptor blockers, therefore, it is not characterized by the disadvantages of antihistamines, such as: suppression of the central nervous system, cardiotoxic effect, headache, impaired coordination of movements, photosensitivity. Analysis of fexofenadine hydrochloride was performed using UV spectroscopy. The purpose of the study – development of a new analytical method for the qualitative and quantitative identification of fixofenadine in drops for in-ternal use. Material and methods. The study used: fexofenadine, sodium hydroxide, water for injection, UV spectrophotometer type SF-104. Results and conclusions. A method for the qualitative and quantitative determination of fexofenadine hydrochloride in model drops for internal use by the SPS method has been proposed. This method meets the requirements of OFS 1.1.0012.15 Validation of analytical methods, in terms of indica-tors: linearity and analytical area, correctness, precision.
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Fuda, Kiyoshi, Kenji Murakami, and Shigeaki Sugiyama. "Thermoelectric Properties of Phase Separated Composite of Ln-Doped SrTiO3 and TiO2 Micro Crystals." MRS Proceedings 1044 (2007). http://dx.doi.org/10.1557/proc-1044-u06-07.
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AbstractIt seems that no satisfactory TE property has been found in n-type oxide bulk materials even though Al-doped ZnO and La-doped SrTiO3 have high thermoelectric (TE) responses. Difficulty in developing high-performance TE materials seems to lie in finding low thermal conductivity in such oxides. The purpose of this study is to find a possibility to make an n-type TE oxide bulk material having low thermal conductivity and excellent TE properties as well. For this purpose, we fabricated and examined a series of composites constructed of TiO2 and Ln-doped SrTiO3 fine crystals. The composites were prepared via two processing steps: (1) precursor oxide preparation by wet processes; (2) sintering by using spark plasma sintering (SPS) apparatus. The microscopic structure was examined by using scanning electron microscope (SEM; HITACHI S-4500 model) attached with an energy dispersive x-ray spectroscopy. The electrical conductivities and the Seebeck coefficients were measured simultaneously using an ULVAC ZEM-1 instrument in helium atmosphere. The thermal diffusivities were measured by a laser flash method in vacuum. The composites obtained here were found to commonly have a mosaic type texture constructed of TiO2 and SrTiO3 fine particles with a typical size of 500 nm. The thermal conductivity values measured for three samples with different contents are ranged between 3 and 4 Wm-1K-1 in the temperature range from room temperature to 800 C. The values are apparently lower than the value for single crystal SrTiO3 samples presented in literature. Taking account the other TE data, e.g. Seebeck coefficient and electrical conductivity, we calculated dimensionless figure of merit, ZT, to be at maximum 0.15 at 800°C.