Academic literature on the topic 'Sputum production'

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Journal articles on the topic "Sputum production"

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Pope, C., R. Spacie, S. Reynolds, and H. Jones. "Quantifying sputum production in intensive therapy." Critical Care 18, Suppl 1 (2014): P309. http://dx.doi.org/10.1186/cc13499.

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Crichton, Megan L., Mike Lonergan, Alan F. Barker, et al. "Inhaled aztreonam improves symptoms of cough and sputum production in patients with bronchiectasis: a post hoc analysis of the AIR-BX studies." European Respiratory Journal 56, no. 1 (2020): 2000608. http://dx.doi.org/10.1183/13993003.00608-2020.

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IntroductionInhaled antibiotics may improve symptom scores, but it is not known which specific symptoms improve with therapy. Item-level analysis of questionnaire data may allow us to identify which specific symptoms respond best to treatment.MethodsPost hoc analysis of the AIR-BX1 studies and two trials of inhaled aztreonam versus placebo in bronchiectasis. Individual items from the quality of life bronchiectasis (QOL-B) respiratory symptom scale, were extracted as representing severity of nine distinct symptoms. Generalised linear models were used to evaluate changes in symptoms with treatment versus placebo from baseline to end of first on-treatment cycle and mixed models were used to evaluate changes across the full 16-week trial.ResultsAztreonam improved cough (difference 0.22, 95% CI 0.08–0.37; p=0.002), sputum production (0.30, 95% CI 0.15–0.44; p<0.0001) and sputum colour (0.29, 95% CI 0.15–0.43; p<0.0001) versus placebo equating to a 20% improvement in cough and 25% improvement in sputum production and colour. Similar results were observed for cough, sputum production and sputum purulence across the trial duration (all p<0.05). Patients with higher sputum production and sputum colour scores had a greater response on the overall QOL-B (difference 4.82, 95% CI 1.12–8.53; p=0.011 for sputum production and 5.02, 95% CI 1.19–8.86; p=0.01 for sputum colour). In contrast, treating patients who had lower levels of bronchitic symptoms resulted in shorter time to next exacerbation (hazard ratio 1.83, 95% CI 1.02–3.28; p=0.042).ConclusionBaseline bronchitic symptoms predict response to inhaled aztreonam in bronchiectasis. More sensitive tools to measure bronchitic symptoms may be useful to better identify inhaled antibiotic responders and to evaluate patient response to treatment.
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Lu, Korina Yun-Fan, Hend Alqaderi, Saadoun Bin Hasan, et al. "Sputum production and salivary microbiome in COVID-19 patients reveals oral-lung axis." PLOS ONE 19, no. 7 (2024): e0300408. http://dx.doi.org/10.1371/journal.pone.0300408.

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SARS-CoV-2, a severe respiratory disease primarily targeting the lungs, was the leading cause of death worldwide during the pandemic. Understanding the interplay between the oral microbiome and inflammatory cytokines during acute infection is crucial for elucidating host immune responses. This study aimed to explore the relationship between the oral microbiome and cytokines in COVID-19 patients, particularly those with and without sputum production. Saliva and blood samples from 50 COVID-19 patients were subjected to 16S ribosomal RNA gene sequencing for oral microbiome analysis, and 65 saliva and serum cytokines were assessed using Luminex multiplex analysis. The Mann-Whitney test was used to compare cytokine levels between individuals with and without sputum production. Logistic regression machine learning models were employed to evaluate the predictive capability of oral microbiome, salivary, and blood biomarkers for sputum production. Significant differences were observed in the membership (Jaccard dissimilarity: p = 0.016) and abundance (PhILR dissimilarity: p = 0.048; metagenomeSeq) of salivary microbial communities between patients with and without sputum production. Seven bacterial genera, including Prevotella, Streptococcus, Actinomyces, Atopobium, Filifactor, Leptotrichia, and Selenomonas, were more prevalent in patients with sputum production (p<0.05, Fisher’s exact test). Nine genera, including Prevotella, Megasphaera, Stomatobaculum, Selenomonas, Leptotrichia, Veillonella, Actinomyces, Atopobium, and Corynebacteria, were significantly more abundant in the sputum-producing group, while Lachnoanaerobaculum was more prevalent in the non-sputum-producing group (p<0.05, ANCOM-BC). Positive correlations were found between salivary IFN-gamma and Eotaxin2/CCL24 with sputum production, while negative correlations were noted with serum MCP3/CCL7, MIG/CXCL9, IL1 beta, and SCF (p<0.05, Mann-Whitney test). The machine learning model using only oral bacteria input outperformed the model that included all data: blood and saliva biomarkers, as well as clinical and demographic variables, in predicting sputum production in COVID-19 subjects. The performance metrics were as follows, comparing the model with only bacteria input versus the model with all input variables: precision (95% vs. 75%), recall (100% vs. 50%), F1-score (98% vs. 60%), and accuracy (82% vs. 66%).
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Rusi Syarri, Yani, Yayang Harigustian, and Venny Diana. "Literature Review : Implementation of Effective Cough on Sputum Production in Tuberculosis Patients." Health Media 3, no. 2 (2022): 36–43. http://dx.doi.org/10.55756/hm.v3i2.97.

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Background : Tuberculosis is an infectious disease that can attack the lungs and organs outside the lungs. One of the signs and symptoms of tuberculosis is coughing. Effective cough aims to remove sputum in the airway. Objective: To identify the implementation of effective cough therapy on sputum production in tuberculosis patients. Methods: This study used a literature review method by determining the keywords tuberculosis, effective cough and sputum production. Then an article search was carried out until 3 research articles were found to be analyzed. Result: The results of this study used 3 research articles that matched the inclusion criteria set by the authors. From the results of the analysis of the three research articles used, it is known that the three articles used effective coughing techniques in removing sputum in Tuberculosis patients. Conclusion: From the results of the literature review, it can be seen that the effective cough technique is the right technique in removing sputum
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Cammarata, Sue Killion, John Dircks, Geoffrey Grambau, and Robert Hyzy. "Elevated Right Hemidiaphragm with Yellow Sputum Production." Chest 99, no. 6 (1991): 1463–65. http://dx.doi.org/10.1378/chest.99.6.1463.

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Zheng, Shanzi, Masaru Yanai, Toshifumi Matsui, Kiyohisa Sekizawa, and Hidetada Sasaki. "Nocturnal cough in patients with sputum production." Lancet 350, no. 9081 (1997): 864–65. http://dx.doi.org/10.1016/s0140-6736(05)62033-8.

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Karinja, Miriam N., Tonya M. Esterhuizen, Sven O. Friedrich, and Andreas H. Diacon. "Sputum Volume Predicts Sputum Mycobacterial Load during the First 2 Weeks of Antituberculosis Treatment." Journal of Clinical Microbiology 53, no. 4 (2014): 1087–91. http://dx.doi.org/10.1128/jcm.02379-14.

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Disease severity in patients with pulmonary tuberculosis is associated with mycobacterial sputum load. To ascertain whether reduced sputum production during treatment is a useful clinical sign of improvement, we analyzed the mycobacterial loads of 5,552 sputum samples collected from 439 newly diagnosed sputum smear-positive tuberculosis patients who participated in six 14-day studies of antituberculosis treatment. Sputum volumes were categorized as low (<6 ml), medium (6 to 10 ml), or large (>10 ml), and mycobacterial load was measured by the time to positivity in liquid culture and the CFU counts on solid culture. The association of sputum volume with mycobacterial load was estimated with multiple linear regression models adjusted for repeated measures. The predictor variables were sputum volume category, treatment day, specific study , and the interaction of sputum volume category and treatment day. Mycobacterial load was significantly associated only with the day on treatment and sputum volume, which tended to decrease with ongoing treatment. With the volume held constant, each day on treatment decreased the log CFU by 0.082 (P< 0.001) and increased the time to positivity (TTP) by 1.04 h (P< 0.001). From low to medium and from medium to large sputum volumes, the log CFU/ml increased by 0.265 (P< 0.003) and 0.490 (P< 0.001), respectively, and the TTP decreased by 1.17 h (P< 0.001) and 1.30 h (P< 0.001), respectively, for a given day of treatment. The variability of the sputum load measurements increased with the day of treatment and lower sputum volumes. The significant association of sputum volume and mycobacterial load validates decreasing sputum production as a clinical sign of improvement during early antituberculosis treatment.
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Afrianus Afrianus, Diah Pujiastuti, and Margaretha Rina Anjarwati. "EFEKTIVITAS KOMBINASI FISIOTERAPI DADA DAN SUCTION TERHADAP PENURUNAN PRODUKSI SPUTUM PADA PASIEN GAGAL NAFAS DI RUANG ICU RUMAH SAKIT SWASTA 2024: CASE REPORT." ASSYIFA : Jurnal Ilmu Kesehatan 2, no. 1 (2024): 141–45. http://dx.doi.org/10.62085/ajk.v2i1.56.

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Respiratory failure is a failure in the gas exchange function between oxygen and carbon dioxide which can cause decreased consciousness. One of the complications of decreased consciousness that is often encountered is sputum retention. The intervention carried out was chest physiotherapy combined with suction. Based on a preliminary study, it was found that 24 (80%) experienced respiratory failure. To reduce sputum production in patients with respiratory failure with chest physiotherapy intervention combined with suction in the ICU of a private hospital. The research method used in this research is a case report by conducting intervention observations and also airway clearance research with 1 respondent. After chest physiotherapy combined with suction, the results showed an increase in oxygen saturation from 88% to 99% and sputum production decreased from ± 10 cc to ± 7 cc. After chest physiotherapy combined with suction for 3 days, significant results were obtained, namely an increase in oxygen saturation and also a decrease in sputum production. ICU nurses are expected to be able to apply chest physiotherapy combined with suction to reduce sputum production in patients with respiratory failure in the ICU by paying attention to vital signs. Intervention is carried out once a day.
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Akpinar-Elci, Muge, Kimberly J. Stemple, Paul L. Enright, et al. "Induced Sputum Evaluation in Microwave Popcorn Production Workers." Chest 128, no. 2 (2005): 991–97. http://dx.doi.org/10.1378/chest.128.2.991.

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Martin, Clémence, and Pierre-Régis Burgel. "Do Cough and Sputum Production Predict COPD Exacerbations?" Chest 156, no. 4 (2019): 641–42. http://dx.doi.org/10.1016/j.chest.2019.06.023.

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Dissertations / Theses on the topic "Sputum production"

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Pierre, Cassandra Marie. "Significance of sputum volume production in tuberculosis patients in Kampala, Uganda." Thesis, Boston University, 2013. https://hdl.handle.net/2144/11024.

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Thesis (M.S.)--Boston University<br>Background: Traditionally, the concentration of mycobacteria in the sputum has been used as a marker of severity as well as a measure of treatment response in pulmonary tuberculosis (TB), however, because of its poor sensitivity for the prediction of TB treatment outcomes (particularly in HIV co-infected patients) more effective surrogate markers are needed. Sputum volume itself has not been previously studied as a potential determinant of treatment outcome. Objectives: To assess the association between sputum volume and clinical and radiographic markers of pulmonary TB as well as treatment outcomes among a sample of patients treated for pulmonary tuberculosis at the Mulago Hospital Uganda National Tuberculosis and Leprosy Programme (NTLP) Clinic in Kampala, Uganda. Methods and Findings: Patients admitted to NTLP between July 2003 to January 2007 were enrolled into a prospective cohort study to assess treatment outcomes during and after a course of antituberculous therapy. From this cohort, a secondary analysis of 391 study participants (with a mean follow-up time of 55 months) was conducted to assess the relationship between baseline sputum volume and TB treatment outcome. Of 296 subjects with at least one spot sputum at baseline, a multivariable analysis revealed that having higher volume sputum (≥ 3 ml) at baseline was significantly associated with the presence of cavitary disease (odds ratio (OR) 2.06, 95% confidence interval (CI) 1.2-3.54) and male gender (OR 2.1, 95% CI 1.22-3.62). Among 196 participants with spot sputum specimens who had sufficient microbiologic or demographic data to make a determination regarding their TB treatment outcome, a multivariable logistic regression revealed that having higher volume sputum (≥ 3 ml) at baseline (OR 5.76, 95% CI 1.6-28.56, p = 0.03), increased duration of pre-treatment TB symptoms(≥ 12 weeks; OR 8.07, 95% (11.69-38.59, p = 0.009) and receipt of post-secondary school education (OR 21.03, 95% CI 2.49-177.55, p = 0.005) had significant associations with an unsuccessful TB treatment outcome. Conclusions: Sputum volume produced at the time of pulmonary TB diagnosis is associated with gender and cavitary disease. Of interest, there is a statistically significant increased risk for unsuccessful TB treatment outcomes among those with higher baseline sputum spot volume (≥ 3 ml) in comparison to those with lower sputum volume (<3 mL).
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Khurana, Shruti. "Lung physiology & airway inflammation in COPD patients with persistent sputum production." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/lung-physiology-and-airway-inflammation-incopd-patients-with-persistent-sputum-production(b0f3374e-9a67-4ff9-a51e-d94eefa2f13c).html.

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Background: The clinical and pathological presentation of COPD is heterogeneous. ‘Chronic bronchitis’ is a phenotype of COPD, which is a clinical diagnosis of a productive cough of ≥ 3 months for ≥ 2 consecutive years. Chronic bronchitis is associated with worse lung function, frequent exacerbations, recurrent hospitalisations and premature death in patients with COPD. Chronic bronchitis sufferers can be further subphenotyped into those who produce sputum during exacerbation or during winter months only and those who are ‘persistent sputum producers,’ who experience mucous hypersecretion throughout the year. An improved understanding of persistent sputum producers is the object of this thesis. Aims: 1) To compare the clinical characteristics and airway inflammatory biomarker profile of COPD persistent sputum producers to that of COPD sputum non-producers 2) To investigate the short term repeatability of sputum parameters in COPD persistent sputum producers 3) To study the expression and relationship of mucins, hypoxia inducible factor (HIF-1α) and carbonic anhydrase IX (CAIX) in COPD persistent sputum producers. Methods: 1) Lung physiology, health status, sputum inflammatory biomarkers and sputum culture results were compared between COPD persistent sputum producers and sputum non-producers 2) Repeatability of spontaneous and induced sputum parameters at 8 weeks was assessed in COPD persistent sputum producers 3) Immunohistochemistry was performed on bronchial biopsies of COPD persistent sputum producers and control groups (COPD sputum non-producers, smokers with normal lung function and lifelong healthy non-smokers with normal lung function) to study the expression of MUC5AC, MUC5B, HIF-1α and CAIX 4) The association between HIF-1α and MUC5B expression was investigated in vitro. Results and Conclusions: The findings suggest that 1) COPD persistent sputum producers have clinically more severe disease, increased airway inflammation, increased impact on health status, increased rate of bacterial colonization and higher number of exacerbations compared to COPD sputum non-producers 2) Induced sputum is repeatable over short term in COPD persistent sputum producers 3) Expression of MUC5B, HIF-1α and CAIX is increased in COPD persistent sputum producers compared to COPD sputum non-producers, smokers with normal lung function and healthy non-smokers 4) HIF-1α can potentially cause increased MUC5B expression. This work reveals potential targets for the development of novel therapies to limit mucous hypersecretion in COPD.
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Terrell, Andrew S. "The effect of hydro-acoustic therapy on sputum production in patients with cystic fibrosis." Thesis, Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/17076.

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Books on the topic "Sputum production"

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Macfarlane, Dawn J. The purification of neutrophil collagenase and gelatinase B from CF sputum &: The modulation of collagen production in human lung fibroblasts by inflammatory cytokines. University College Dublin, 1995.

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Jones, Andrew M., and Rowland J. Bright-Thomas. Bronchiectasis. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0137.

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Bronchiectasis may be defined clinically as the chronic daily production of copious mucopurulent sputum. Pathologically, the disease is characterized by inflamed, thick-walled, dilated bronchi. Bronchiectasis has many potential underlying causes and associations with other diseases but in individual cases the underlying cause is often unknown. The typical symptom is cough with sputum. Bronchiectasis is a chronic condition; systemic complications are common and include tiredness, malaise, and weight loss. The aim of therapy should be to control symptoms, prevent complications and disease progression, while minimizing treatment burden. This chapter discusses bronchiectasis, including its etiology, symptoms, demographics, natural history, complications, diagnosis, prognosis, and treatment.
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Grundy, Seamus. Pleural infection and malignancy. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0143.

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Pleural infection transitions from simple parapneumonic effusion, to complex parapneumonic effusion, to empyema. Primary empyema occurs without an underlying pneumonic process. Pleural infection commonly presents identically to pneumonia with dyspnoea, purulent sputum, and fevers. It may be associated with pleuritic chest pain. Empyema can cause systemic sepsis, leading to cardiovascular instability and multi-organ failure. A malignant pleural effusion arises when malignant cells infiltrate the pleura, resulting in increased production and decreased lymphatic drainage of pleural fluid. Malignant pleural effusions are either metastatic or primary mesothelioma. This chapter discusses pleural infection, malignant pleural effusion, and mesothelioma, focusing on etiology, symptoms, demographics, diagnosis, prognosis, and treatment.
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Sahetya, Sarina. Acute Uncomplicated Bronchitis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0029.

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Acute bronchitis is a respiratory illness characterized predominantly by cough with or without sputum production that lasts for up to 3 weeks in the presence of normal chest radiography. Additional presenting symptoms include rhinorrhea, congestion, sneeze, sore throat, wheezing, low-grade fever, myalgia, and fatigue. Causative organisms include viral and bacterial pathogens. The disease course is characterized by self-limited inflammation of the airways. Chest radiographs should be utilized to distinguish acute bronchitis from pneumonia or interstitial disease. Therapeutic recommendations are typically supportive; however, studies reveal that between 60% and 80% of patients receive unwarranted antibiotic therapy. Only those patients at high risk for serious complications (including patients over 65 with a history of hospitalization, diabetes mellitus, congestive heart failure, or current use of oral glucocorticoids) usually require routine antibiotic therapy directed toward both typical and atypical bacterial pathogens.
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Lupton, Joshua. Hospital Acquired Pneumonia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0023.

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Pneumonia consists of inflammation of the pulmonary parenchyma, typically resulting from a microbial infection. Hospital-acquired pneumonia (HAP) occurs in (typically elderly) patients in long-term care facilities, with regular IV therapy, with immunosuppression, or with a history of recent treatment at a hospital. It is associated with high mortality. The majority HAP patients present with some constellation of cough, fever, sputum production, and pleuritic chest pain. Patients with chronic obstructive pulmonary disease (COPD) and cystic fibrosis are at increased risk for pneumonia. The Infectious Disease Society of America requires infiltrates on chest x-ray or other imaging for the diagnosis of pneumonia. For hospitalized patients, empiric antimicrobial therapy for HAP should be given as soon as pneumonia is highly suspected. There is currently a vaccine available against Streptococcus pneumonia that all patients should be offered before discharge from the hospital. The elderly are already more susceptible to HAP due to decreased mobility and increased comorbidities.
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Circh, Ryan. Community-Acquired Pneumonia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0022.

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Community-acquired pneumonia (CAP) is defined as an acute infection of the pulmonary parenchyma in someone who has not recently had close contact with the health care system. Common presentations include abrupt fever and chills, productive cough, purulent sputum, dyspnea, pleuritic chest pain, and the absence of rhinorrhea and sore throat. Prompt antibiotics and admission to the correct level of care are essential in emergency management. Chest radiographs and dry computed tomography (CT) scans can be extremely useful in confirming the diagnosis of CAP in immunocompetent patients. Assessment of the airway, breathing, and circulation is essential. Adequate fluid resuscitation, early appropriate antibiotics, and careful attention to monitoring are still mainstays of treatment. Clinical decision tools like CURB-65 and PORT score can help identify low-risk patients when making decisions about whether or not to admit.
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Mehta, Smith, Alisa Perren, Michael Curtin, et al. The New Screen Ecology in India. Bloomsbury Publishing Plc, 2023. http://dx.doi.org/10.5040/9781839025693.

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This book provides an in depth look into the digital transformation of the Indian media industries, arguing that it has primarily been facilitated by the advent of social media platforms and a resulting shift in the creator dynamics of contemporary film and television production. Drawing on first-hand research within three categories of agents: creators, platform and portal executives, and intermediaries (talent agents, and multi-channel networks), Smith Mehta develops the concept of the ‘new screen ecology’ to show how the Indian screen industries are affected by social relations between these actors and how industrial practices blur the amateur-professional divide through creator and content interdependencies. Mehta interrogates the production practices of 13 different platforms and portals, including Hotstar, Netflix, YouTube, and TVFPlay, analyzing the extent to which they benefit from the lack of censorship and restrictive industrial practices characteristic of traditional media structures. In doing so, he examines the dynamics of digital transformation in the screen industries in a region-specific context and contributes to a body of literature on Indian digital production cultures. This book investigates the political, social and economic transactions that led to the digital transformation of the Indian audio-visual industries. It traces the interdependences between two social (YouTube, Facebook) and eleven digital (Hotstar, Spuul, Hoichoi, Addatimes, TVFPlay, Reliance Jio, Zee5, Voot, Netflix, Amazon Prime Video, AltBalaji) video streaming services, in platforming content drawn from both professional and professionalizing-amateur sources. Drawing on approaches from critical media industries studies, political economy and cultural studies, it interrogates the shifting creator dynamics in contemporary Indian film and television production with the advent of internet-based local and global video distribution services. In doing so, it brings to light the contribution of Indian intermediaries such as talent agents and third-party service providers that manage YouTube channels, also referred to as multichannel networks, in facilitating the localisation strategies of global portals such as Netflix and Amazon Prime, enabling the movement of creators from platforms to portals and expanding their value propositions through investments in content and talent-led ventures.
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Book chapters on the topic "Sputum production"

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Ozsoy, Ibrahim Ethem, and Mehmet Akif Ekici. "Bronchiectasis." In Thoracic Infections. Nobel Tip Kitabevleri, 2024. http://dx.doi.org/10.69860/nobel.9786053358930.5.

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Bronchiectasis is defined as the permanent, chronic, and irreversible abnormal dilation of the airways.Bronchiectasis can result from a multitude of different underlying disorders, making the identification of its etiology crucial for guiding treatment.Patients commonly present with chronic cough, copious sputum production, and recurrent pneumonia attacks. The diagnosis of bronchiectasis is established through clinical and radiological findings. The objectives of treatment are to reduce recurrent pneumonia attacks, enhance quality of life, and halt disease progression.Bronchiectasis remains a common chronic lung disease that can affect the quality of life and expectancy of those affected. We recommend the surgical removal of affected lung regions in clinically selected patients.
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van de Graaf, E. A., T. A. Out, and H. M. Jansen. "The Measuring of “Respiratory-Membrane Permeability” and Local Production of Immunoglobulins and Antibodies by Means of an Analysis of Sputum." In Inflammatory Indices in Chronic Bronchitis. Birkhäuser Basel, 1990. http://dx.doi.org/10.1007/978-3-0348-7488-5_20.

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"Cough, sputum, and fever." In Emergencies in Respiratory Medicine, edited by Robert Parker, Catherine Thomas, and Lesley Bennett. Oxford University Press, 2007. http://dx.doi.org/10.1093/med/9780199202447.003.0005.

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Cough, sputum, and fever 34 The development of the combination of a cough, sputum production, and a fever usually implies pulmonary infection of some form. It may be a new infection in otherwise normal lungs, e.g. pneumonia, or the worsening of a chronic disease, e.g. bronchiectasis or COPD. The assessment of the patient follows the standard format....
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Robinson, Chapman. "Bronchiectasis." In Oxford Handbook of Respiratory Medicine, edited by Stephen J. Chapman, Grace V. Robinson, Rahul Shrimanker, Chris D. Turnbull, and John M. Wrightson. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198837114.003.0019.

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Bronchiectasis is irreversible abnormal dilatation of one or more bronchi, with chronic airway inflammation. It is associated with chronic sputum production, recurrent chest infections, and airflow obstruction.
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"Chest pain." In Emergencies in Respiratory Medicine, edited by Robert Parker, Catherine Thomas, and Lesley Bennett. Oxford University Press, 2007. http://dx.doi.org/10.1093/med/9780199202447.003.0007.

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Chest pain 46 There are many causes of chest pain, both respiratory and non-respiratory. Differentiating between them relies on a thorough history and examination, giving rise to diagnosis by pattern recognition, as well as appropriate investigations. • Pneumonia: associated with fever, rigors, sputum production. Consolidation on CXR....
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Currie, Graeme P. "Making the diagnosis of COPD." In Chronic Obstructive Pulmonary Disease. Oxford University PressOxford, 2009. http://dx.doi.org/10.1093/oso/9780199563685.003.0003.

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Abstract Typical symptoms of COPD include breathlessness, chest tightness, wheeze, cough, sputum production (especially in the mornings), reduced exercise capacity, and frequent chest infections. Many other medical conditions have features similar to COPD and need to be excluded. Breathing tests—known as spirometry—are required to diagnose COPD with certainty.
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Humphreys, Hilary. "Case 7." In Oxford Case Histories in Infectious Diseases and Microbiology, edited by Maheshi Ramasamy. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198846482.003.0007.

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Acute exacerbations of chronic obstructive pulmonary disease (COPD) are a frequent cause of acute admission to hospital. These may be characterized by increased sputum production or a change in character, from mucoid to purulent, but microbiological analysis of sputum in such patients is usually not rewarding. With the use of molecular diagnostics, viral causes are increasingly recognized such as respiratory synctial virus and meta-pneumovirus. Many patients do not require an antibiotic as part of therapy but where indicated an agent such as co-amoxyclav may be appropriate. Further research on the respiratory microbiome may provide new insights into the dynamics of the normal flora in patients with COPD. Prophylactic antibiotics, such as with a macrolide, is controversial; the immunomodulatory impact may be outweighed by the risk of antibiotic resistance and drug side-effects.
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Harvey, CJ, HRS Roberts, and PJ Shaw. "Respiratory Disease." In Radiology. Oxford University PressNew York, NY, 1999. http://dx.doi.org/10.1093/oso/9780192629029.003.0002.

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Abstract This is a chest radiograph of a 25-year-old female with chronic sputum production. What is the diagnosis? The chest radiograph demonstrates cystic bronchiectasis (ring shadows are seen, particularly in the right upper lobe) with lung hyperinflation in a patient with cystic fibrosis. Bilateral hilar lymphadenopathy is also present. Bronchial wall thickening, appearing like tramlines, is seen in the right perihilar region.
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Pfeifle, Daniel O., and Sarah J. Chalmers. "A 28-Year-Old Woman With Worsening Cough and Hemoptysis." In Mayo Clinic Case Review for Pulmonary and Critical Care Boards, edited by Robert Vassallo. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/med/9780197755877.003.0005.

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Abstract Cystic fibrosis (CF) is characterized by worsening lung function due to chronic inflammation and impaired mucociliary clearance. Symptoms include increased cough, increased sputum production, and dyspnea. Treatment includes hospital admission, IV antibiotics targeted to culture-specific microbes, long-term therapies with intensification of airway clearance therapies, and initiation of CF transmembrane conductance regulator modulator therapy. Hemoptysis can occur independently of CF, or it may indicate acute pulmonary exacerbation and can range from scant, which can be managed in the outpatient setting, to massive, which requires hospitalization. Bronchial artery embolization is first-line therapy for massive hemoptysis, particularly with hemodynamic instability.
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Ali Kamal, Yasser. "Surgical Management of Bronchiectasis." In Update in Respiratory Diseases. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.93103.

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Bronchiectasis is a chronic clinicopathological disease of the lung characterized by chronic cough, sputum production, recurrent pulmonary infection, and persistent bronchial dilatation on computed tomography. For many years, bronchiectasis associated with high mortality and morbidity particularly before the advent of antibiotics. The medical treatment of bronchiectasis includes antibiotic therapy, airway clearance, bronchodilators, and anti-inflammatory agents. Surgery is mainly performed for localized disease after failure of the medical treatment, including: segmentectomy, lobectomy, and pneumonectomy. This chapter highlights the current surgical considerations for treatment of bronchiectasis, regarding indications of surgery, preoperative evaluation and preparation, available operative procedures, postoperative outcomes, and other important surgical issues.
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Conference papers on the topic "Sputum production"

1

Donaldson, G. C., D. J. Wiseman, A. I. Ritchie, M. Macleod, J. Allinson, and J. A. Wedzicha. "Duration of Persistent Sputum Production Is Related to Lung Function Decline." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4562.

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2

Tummino, Céline, Khudr Alagha, Delphine Gras, et al. "Cough And Sputum Production In Severe Asthma: A Specific Disease Phenotype?" In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2554.

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3

Alghamdi, S. M., K. E. Philip, A. S. Alsulayyim, et al. "Cough Frequency in Chronic Obstructive Pulmonary Disease (COPD) with Frequent Sputum Production." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2812.

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4

Cant, E., M. Bottier, M. Shuttleworth, et al. "IL-4 levels in sputum correlate with increased mucus production and ciliary dysfunction." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.2958.

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5

John, Michelle, Sam Hussain, and Charlotte E. Bolton. "The Association Of Sputum Production And Arterial Stiffness In Chronic Obstructive Pulmonary Disease (COPD)." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3979.

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6

Krumpe, Peter. "Potential Benefits of Bronchoconstriction and Thick Airway Mucus." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2593.

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Abstract Wheezes and sputum production are two hallmarks of lung disease. Both are associated with airway obstruction and increased work of breathing. Why should our species invest such a considerable amount of genetic material in the support of airway changes that are viewed as evidence of pathological lung disease? Perhaps bronchoconstriction and thick airway mucous provide advantages in defense of airway clearance that outweighs the mechanical cost of airway obstruction.
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Karim, Khennouf, Samya Taright, and Aziza Fissah. "Frequent exacerbations of COPD are associated with severity of airflow limitation and chronic cough, sputum production." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa4288.

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8

Kasaraneni, N., D. Roy, N. Bhangoo, et al. "Effects of Vaping of Nicotine and THC E-cigarettes on Airway Resistance, Saliva, and Sputum Production." In American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2622.

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Liu, X., X. Zhou, X. Zhang, et al. "Uncontrollable Production of a Large Volume of Sputum With Marked Reduction Following SARS-CoV-2 Infection." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7432.

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Toljamo, T., M. Kaukonen, P. Nieminen, and VL Kinnula. "Detailed Questionnaire Reveals High Prevalence of Cough and Sputum Production in Healthy Cigarette Smokers, 2-Year Prospective Study." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5887.

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