Academic literature on the topic 'Squamous cell carcinoma of the oral cavity'

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Journal articles on the topic "Squamous cell carcinoma of the oral cavity"

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Bewley, Arnaud F., and D. Gregory Farwell. "Oral leukoplakia and oral cavity squamous cell carcinoma." Clinics in Dermatology 35, no. 5 (September 2017): 461–67. http://dx.doi.org/10.1016/j.clindermatol.2017.06.008.

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Odukoya, Onatolu, Adeyemi Mosadomi, Danny R. Sawyer, Adenike Orejobi, and Ayo Kekere-Ekun. "Squamous cell carcinoma of the oral cavity." Journal of Maxillofacial Surgery 14 (January 1986): 267–69. http://dx.doi.org/10.1016/s0301-0503(86)80302-2.

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Aulino, Joseph M., Megan K. Strother, and Jason L. Shipman. "Imaging of Oral Cavity Squamous Cell Carcinoma." Oral and Maxillofacial Surgery Clinics of North America 18, no. 4 (November 2006): 445–63. http://dx.doi.org/10.1016/j.coms.2006.06.011.

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Howard, Adam, Nishant Agrawal, and Zhen Gooi. "Lip and Oral Cavity Squamous Cell Carcinoma." Hematology/Oncology Clinics of North America 35, no. 5 (October 2021): 895–911. http://dx.doi.org/10.1016/j.hoc.2021.05.003.

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Markopoulos, Anastasios K. "Current Aspects on Oral Squamous Cell Carcinoma." Open Dentistry Journal 6, no. 1 (August 10, 2012): 126–30. http://dx.doi.org/10.2174/1874210601206010126.

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Oral squamous cell carcinoma is the most common malignant epithelial neoplasm affecting the oral cavity. This article overviews the essential points of oral squamous cell carcinoma, highlighting its risk and genomic factors, the potential malignant disorders and the therapeutic approaches. It also emphasizes the importance of the early diagnosis.
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Kintawati, Silvi. "Corellation of p53 expressions and histopathological grading in oral cavity squamous cell carcinoma." Dental Journal (Majalah Kedokteran Gigi) 49, no. 3 (September 30, 2016): 120. http://dx.doi.org/10.20473/j.djmkg.v49.i3.p120-124.

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Background: Squamous cell carcinoma is a malignancy of oral cavity mostly occurred and can also metastasize. p53 gene is a tumor suppressor gene that plays an important role in carcinogenesis. The role of wild-type p53 is very important in suppressing the formation of a malignancy. p53 also has many other important functions. p53 is a suppressor of tumor/ cancer progression through the response of cell cycle to DNA damage and by giving time to repair DNA prior to replication of genes. p53 mutation, mostly occurs in a malignancy, so earlier histopathological transformation can be detected by observing p53 mutation. The prognosis of squamous cell carcinoma in oral cavity, therefore, depends on histopathological grading and clinical staging of the tumor. To enforce the histopathological grading, in addition based on histopathology differentiation, the earlier histopathological transformation can also be assessed. Purpose: This study aimed to determine the correlation of p53 expressions and histopathological grading in oral cavity squamous cell carcinoma. Method: This study was a retrospective study on 20 cases of oral cavity squamous cell carcinoma examined at Department of Pathology Anatomy in Hasan Sadikin Hospital in Bandung. Immunohistochemical examination was then performed using p53 antibodies to determine the correlation of p53 expression and histopathological grading in oral cavity squamous cell carcinoma to predict prognosis. Result: The overall results showed that there was no correlation between p53 expression and histopathological grading in oral cavity squamous cell carcinoma of the oral cavity although there was a very strong correlation between p53 expression and histopathological grading I (p<0.01). Conclusion: It can be concluded that there was no correlation between p53 expression and histopathological grading in oral cavity squamous cell carcinoma. Thus, p53 expression cannot be used to predict a prognosis.
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Patni, Parth, Deepak Dalmia, Narsinha Davange, Karthika Bhagavan, Amit Palwade, and Rizul Goyal. "Level IIb involvement in oral cavity squamous cell carcinoma." International Journal of Otorhinolaryngology and Head and Neck Surgery 7, no. 2 (January 25, 2021): 292. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20210159.

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<p><strong>Background:</strong> Cervical lymph node status is the most significant prognostic factor in the treatment of patients with OSCC. Adequate clearance of level IIb lymph nodes require traction and elevation of the spinal accessory nerve (SAN) and can lead to consequent shoulder problems.Therefore, avoiding the dissection of level IIb has been increasingly proposed to overcome this complication. The aim of this study was to determine the prevalence of level IIb metastasis in patients with oral squamous cell carcinomas (OSCCs).</p><p><strong>Methods: </strong>A total of 106 newly diagnosed oral cavity cancer patients requiring surgery as the primary modality were included in the study. Preoperative clinical examinations were done and tumor-node-metastasis staging was noted. Intraoperative, level IIb nodal tissue was dissected and sent separately.</p><p><strong>Results: </strong>A total of 106 neck dissections were done out of which male: female ratio of 2.78:1. 49.05% patients were suffering from buccal mucosa carcinoma followed by tongue carcinoma (22.64%). 52.83% of patients had no neck involvement. Among neck positive cases, pN1 was the most common presentation. Out of these, only 8 (7.54%) neck dissections had level IIb positive.</p><p><strong>Conclusions: </strong>Dissection of the level IIb region in patients with OSCC may be required only in cases with advanced N stage, positive level IIa lymph nodes, and extra capsular spread. Further evaluation can be done among various subsites of OSCC, clinical staging of tumour, occult bilateral nodal metastasis to assess the need of resection of level IIb in OSCC.</p>
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Tan, Marietta, Jeffrey N. Myers, and Nishant Agrawal. "Oral Cavity and Oropharyngeal Squamous Cell Carcinoma Genomics." Otolaryngologic Clinics of North America 46, no. 4 (August 2013): 545–66. http://dx.doi.org/10.1016/j.otc.2013.04.001.

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Chen, T. M., J. T. Chang, I. H. Chen, C. J. Kang, and C. T. Liao. "111 Early stage oral cavity squamous cell carcinoma." European Journal of Cancer Supplements 1, no. 5 (September 2003): S38. http://dx.doi.org/10.1016/s1359-6349(03)90144-3.

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DOS SANTOS, HELENA AYRES ALONSO, RAFFAEL MARON, ELLEN BRILHANTE CORTEZZI, BRUNO AUGUSTO BENEVENUTO DE ANDRADE, MÁRIO JOSÉ ROMAÑACH, and MICHELLE AGOSTINI. "ACANTHOLYTIC SQUAMOUS CELL CARCINOMA OF THE ORAL CAVITY." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 129, no. 1 (January 2020): e71. http://dx.doi.org/10.1016/j.oooo.2019.06.279.

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Dissertations / Theses on the topic "Squamous cell carcinoma of the oral cavity"

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Högmo, Anders. "Squamous cell carcinomas and preneoplastic lesions of the oral cavity : biological factors and prognosis /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3370-7/.

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Jatana, Courtney Ann. "Histopathological Characteristics in Squamous Cell Carcinoma of the Oral Cavity with Regard to Presence of Circulating Tumor Cells." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313587893.

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Anand, Sumeet M. 1978. "The correlation between tumour volume and survival in oral cavity and oropharyngeal squamous cell carcinoma /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111587.

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The Tumour-Node-Metastasis (TNM) classification system of tumour stage does not always reflect the actual tumour mass present at diagnosis. Recent reports propose that volumetric analysis may allow improved stratification of disease recurrence and survival in head and neck squamous cell cancer (SCC). This study aims to assess the prognostic value of tumour volume on the outcome of patients with oral cavity and oropharyngeal SCC.
A retrospective review of 73 patients was completed. Tumours were outlined semi-automatically in digitized computed tomography scans, and volumes computed based on surface triangulations of three-dimensional reconstructions with novel software developed at McGill.
Results illustrate significant interstage variability within the current TNM model. Moreover, in oral cavity and oropharyngeal SCC, tumour volume as well as T-stage are significant and independent predictors of disease free survival and overall survival.
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Marinho, Erasmo Bernardo. "Evaluation of the quality of life of post- irradiated patients diagnosed with squamous cell carcinoma of the oral cavity." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16162.

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Radiotherapy is an effective therapeutic modality employed in the management of malignant tumors in the oral cavity. Its use in head and neck results in adverse effects. The measurement of quality of life allows to gather the most common problems in oral cancer patients in a structured way, ranking its intensity and enabling a more accurate clinical control. This study aimed to evaluate the quality of life of post- irradiated diagnosed with squamous cell carcinoma of the oral cavity. Eleven patients over six months of completion of therapy treated at the Hospital Haroldo JuaÃaba â Instituto do CÃncer do Cearà were included in the study. University of Washington quality of life questionnaire, specific to head and neck cancer, was applied. Data related to socio-demographic, clinical, pathological and therapeutic profile were collected. Unstimulated salivary flow was measured by spitting method. Categorical data were exposed in the form of absolute and percentage frequency, and quantitative data as mean  standard deviation, followed by their minimum and maximum. Statistical analysis of quantitative data was performed by nonlinear Spearman correlation, considering a 95% confidence. Most patients were elderly (72.72%), male (81.81%), with lower education (90.9%), away from their work activities since the completion of cancer treatment (90.9%), with a history of smoking (90.9%), alcohol abuse (90.9%) and exposure to sunlight before the onset of the disease (90.9%), with lesions in the mouth floor (45.45%) moderately differentiated type (100%), stage IV (54,54%), subjected to other treatment modalities in addition to radiation therapy (100%). Among the domains assessed, chewing, saliva and speech presented the lowest mean scores (31.8, 42.3 and 60.6, respectively). All participants presented moderate to severe hyposalivation. Statistically significant correlation was found between age and speech (p = 0.043); time of completion of radiation therapy and recreation (p = 0.027); swallowing and pain (p = 0.039); activity and recreation (p = 0.030); swallowing and chewing (p = 0.007); chewing and speaking (p = 0.048); and shoulder and mood (p = 0.004). We conclude that the post- irradiated patients diagnosed with squamous cell carcinoma of the oral cavity tend to consider their quality of life ranging from fair to outstanding and that chewing, saliva and speech domains are those with greater commitment.
A radioterapia à uma modalidade terapÃutica eficaz utilizada no tratamento de tumores malignos da cavidade oral. Sua utilizaÃÃo em regiÃo de cabeÃa e pescoÃo leva ao surgimento de efeitos adversos. A mensuraÃÃo da qualidade de vida permite reunir os problemas mais comuns aos pacientes com cÃncer oral de forma estruturada, classificando sua intensidade, tornando-se possÃvel um controle clÃnico mais apurado. O presente estudo teve como objetivo avaliar a qualidade de vida de pÃs-irradiados com diagnÃstico de carcinoma espinocelular de cavidade oral. Onze pacientes com mais de seis meses de conclusÃo do tratamento, atendidos no Hospital Haroldo JuaÃaba â Instituto do CÃncer do CearÃ, foram incluÃdos no estudo. Foi aplicado o questionÃrio de qualidade de vida da Universidade de Washington, especÃfico para o cÃncer de cabeÃa e pescoÃo. Foram coletados dados relacionados ao perfil sociodemogrÃfico, clÃnico-patolÃgico e terapÃutico. Realizou-se a mensuraÃÃo do fluxo salivar nÃo estimulado atravÃs do mÃtodo de spitting. Dados categÃricos foram expostos em forma de frequÃncia absoluta e percentual e os dados quantitativos em forma de mÃdia  desvio-padrÃo, seguido de sua mÃnima e mÃxima. A anÃlise estatÃstica dos dados quantitativos foi realizada atravÃs da correlaÃÃo nÃo linear de Spearman, considerando uma confianÃa de 95%. Predominaram pacientes idosos (72,72%), do sexo masculino (81,81%), de baixa escolaridade (90,9%), afastados de suas atividades laborais desde a conclusÃo do tratamento oncolÃgico (90,9%), com histÃrico de tabagismo (90,9%), abuso de Ãlcool (90,9%) e exposiÃÃo à luz solar anterior ao surgimento da doenÃa (90,9%), com lesÃes localizadas em soalho de boca (45,45%) do tipo moderadamente diferenciado (100%), estadiamento IV (54,54%), submetidas a outras modalidades de tratamento alÃm da radioterapia (100%). Dentre os domÃnios avaliados, mastigaÃÃo, saliva e fala apresentaram as menores mÃdias de escores (31,8; 42,3 e 60,6, respectivamente). Todos os participantes apresentaram hipossalivaÃÃo de moderada à severa. Constatou-se correlaÃÃo estatisticamente significante entre: idade e fala (p=0,043); tempo de conclusÃo da radioterapia e recreaÃÃo (p=0,027); dor e deglutiÃÃo (p=0,039); atividade e recreaÃÃo (p=0,030); deglutiÃÃo e mastigaÃÃo (p=0,007); mastigaÃÃo e fala (p=0,048); e ombro e humor (p=0,004). Conclui-se que os pacientes pÃs-irradiados com diagnÃstico de carcinoma espinocelular de cavidade oral tendem a considerar de mÃdia a excelente sua qualidade de vida e que os domÃnios de mastigaÃÃo, saliva e fala sÃo os que apresentam maior comprometimento.
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El-Hakim, Ibrahim El-Sayed M. "Study of the 5-lipoxygenase pathway of arachidonic acid metabolism (leukotrienes) in squamous cell carcinoma of the oral cavity." Thesis, King's College London (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669048.

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Abreu, Priscila Marinho de. "HPV e Expressão de p16 como biomarcadores de prognósticos em carcinoma de células escamosas da cavidade bucal." Universidade Federal do Espírito Santo, 2015. http://repositorio.ufes.br/handle/10/4505.

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HPV e Expressão de p16 como Biomarcadores de Prognósticos em Carcinoma de Células Escamosas da Cavidade Bucal
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Abreu, Priscila Marinho de. "HPV e expressão de p16 como biomarcadores de prognóstico em carcinoma de células escamosas da cavidade bucal." Mestrado em Biotecnologia, 2015. http://repositorio.ufes.br/handle/10/1881.

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Biomarcadores de progressão tumoral são importantes na determinação do prognóstico e resposta ao tratamento em carcinoma de células escamosas da cavidade bucal. Este estudo teve como objetivo avaliar a frequência de infecção pelo HPV e a expressão de p16 como biomarcador de prognóstico em carcinoma de células escamosas da cavidade bucal. Dados clínico-patológicos e tecido tumoral de 90 indivíduos com carcinoma de células escamosas da cavidade bucal foram obtidos por entrevista e análise de prontuários. Detecção de HPV foi realizada à partir de amostras de tecido tumoral por PCR utilizando o conjunto de primers PGMY09/11. A seguir, as mesmas amostras foram submetidas à PCR com os primers MY09/11 e nested PCR com os primers GP5+/6+. Expressão de p16 foi detectada por imunohistoquímica. Análise estatística foi feita através de associação de variáveis, utilizando o teste de qui-quadrado e exato de Fisher. Sobrevida doença-específica (SDE) e sobrevida livre de doença (SLD) foram estimadas usando método de Kaplan-Meier. Comparação entre as curvas de sobrevida foram realizadas com o teste Log-Rank. Comparação entre status da infecção pelo HPV e expressão de p16 foram analisadas pelo teste Cox. Todos os testes com P ≤ 0.05 foram considerados significantes. A frequência de infecção pelo HPV na população estudada foi de 3,70% detectadas apenas com a nested PCR. Expressão de p16 foi observada em 21,87% das amostras analisadas. A SDE foi de 25,5 meses (95% IC = 20,03 - 31,00), enquanto a SLD foi de 30 meses (95% IC = 25,63 – 34,48). Maior SDE foi observada em indivíduos com tumores em estádio inicial (I-II) (P=0,001), tumores < 2cm (P=0,001), sem metástase em linfonodos regionais (P=0,006) e aqueles submetidos a tratamento cirúrgico (P<0,0001). Em conclusão, o status da infecção pelo HPV não mostrou-se um bom marcador de prognóstico e parece não ser determinante na tumorigênese em CCE da cavidade bucal, uma vez que apresentou baixa frequência de infecção. A expressão de p16 não foi um indicador determinante da presença de HPV nas amostras estudadas e um maior número de casos é necessário para avaliar sua aplicabilidade como marcador de prognóstico na população estudada.
Tumor progression biomarkers are important in determining prognosis and treatment response in squamous cell carcinoma of the oral cavity. This study aimed to evaluate the frequency of HPV infection and p16 expression as a biomarker of prognosis in squamous cell carcinoma of the oral cavity. Clinicopathological data and tumor tissue of 90 patients with squamous cell carcinoma of the oral cavity were obtained by interview and review of medical records. HPV detection was performed starting from tumor tissue samples by PCR using the primer set PGMY09/11. Next, the same samples were subjected to PCR with primers MY09 / 11 primers and nested PCR with GP5+/6+ primers. P16 expression was detected by immunohistochemistry. Statistical analysis was performed using variable association, using the chi-square and Fisher exact test. Disease-specific survival (DSS) and disease-free survival (DFS) were estimated using Kaplan-Meier. Comparison between the survival curves were performed using the log-rank test. Comparison status of HPV infection and p16 expression were analyzed by Cox test. All tests with P≤0,05 were considered significant. The frequency of HPV infection in this population was 3,70% detected only with nested PCR. p16 expression was observed in 21.87% of the analyzed samples. The DSS was 25.5 months (95% CI = 20.03 to 31.00), while the DFS was 30 months (95% CI = 25.63 to 34.48). Most DSS was observed in subjects with initial stage tumors (I-II) (P=0,001), tumor <2 cm (P=0,001), without regional lymph node metastasis (P=0,006) and those undergoing surgical treatment (P<0,0001). In conclusion, the status of HPV infection not proved to be a good prognostic marker and does not seem to be decisive in tumorigenesis in SCC of the oral cavity, since it showed low frequency of infection. The expression of p16 was not a key indicator of the presence of HPV in all samples and a greater number of cases it is necessary to evaluate its applicability as a prognostic marker in this population.
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Francisco, Ana Lucia Noronha. "System of fluorescence spectroscopy in the evaluation of surgical margins for squamous cell carcinoma of the oral cavity in moments in situ and ex vivo = Sistema de espectroscopia de fluorescência na avaliação de margens cirúrgicas de carcinoma de células escamonas da cavidade oral nos momentos in situ e ex vivo." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289799.

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Orientadores: Luiz Paulo Kowalski, Cristina Kurachi
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: O tratamento mais empregado para os carcinomas de células escamosas da boca é a ressecção cirúrgica, sendo ou não acompanhada de radio e/ou quimioterapia. O tratamento é simplificado, diminuindo número de recidivas e aumentando a sobrevida, quando as lesões encontram-se em estágios iniciais, conforme localização anatômica e diagnóstico de margens cirúrgicas livres. Frente a isto, o desenvolvimento e aperfeiçoamento de técnicas para um diagnóstico precoce, assim como de uma acurada definição das margens cirúrgicas livres e correta delimitação da extensão do câncer boca, com o intuito de melhorar a qualidade de vida e a taxa de sobrevida desses pacientes, tornam-se de grande importância. A espectroscopia de fluorescência é uma ferramenta diagnóstica não invasiva que pode auxiliar na detecção do câncer em tempo real, com o potencial de fornecer sensibilidade e especificidade semelhantes ao diagnóstico clínico de profissionais experientes. É uma técnica relativamente simples, rápida e acurada que consiste em avaliar a composição bioquímica e a estrutura do tecido pelo espectro de fluorescência emitido por ele, após aplicação de um feixe de luz. Quando há progressão de um estado normal para um estado alterado, isso é refletido nas características espectrais da fluorescência dos tecidos, podendo ser correlacionada com o exame histopatológico destes tecidos. O objetivo do presente estudo consistiu em discriminar, na mucosa bucal, tecido sadio de neoplásico, por meio de espectroscopia de fluorescência avaliando as margens ressecadas cirurgicamente. As avaliações ocorreram nos pacientes do Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia do AC Camargo Câncer Center. O estudo obteve aprovação dos Comitês de Ética em Pesquisa das instituições participantes. A amostra consistiu de 75 indivíduos nos quais se realizou a espectroscopia de fluorescência dos quais 45 pacientes eram portadores de carcinoma oral e 30 voluntários com mucosa oral clinicamente normal. 29 casos (64.4%) do sexo masculino e a média de idade foi de 61.3 anos. Foram realizadas biópsias e os resultados destas duas metodologias foram comparados, usando o diagnóstico histopatológico como padrão ouro, para identificar características espectrais de entre tecidos clinicamente não alterados das margens cirúrgicas da mucosa de voluntários. Os espectros foram classificados e comparados com a histopatologia para determinação da eficiência na discriminação diagnóstica empregando-se a fluorescência. A análise inicial foi qualitativa e após consistiu de processamentos matemáticos dos espectros com excitação nos comprimentos de 532 e 406nm. Observou-se a variabilidade entre os indivíduos, entre os sítios anatômicos, entre regiões da mesma lesão e entre tecido clinicamente normal de voluntários e tecido das margens cirúrgicas em momentos in situ. Foram observadas também grandes diferenças entre espectros in situ e ex vivo, em concordância com resultados de outros estudos. A acurácia da técnica variou em função do tipo de análise empregada, mas pode-se constatar o seu potencial de uso como instrumento auxiliar para avaliar margens cirúrgicas no câncer de boca
Abstract: The most widely used treatment for squamous cell carcinoma of the mouth is surgical resection, whether or not accompanied by radiation and/or chemotherapy. The treatment is simplified, reducing the number of recurrences and increasing survival when the lesions are in the early stages, according to anatomical site and diagnosis of disease-free surgical margins. The development and improvement of techniques for early diagnosis, as well as an accurate definition of disease-free surgical margins and correct delineation of the extent of the mouth cancer, is an important part of improving the quality of life and survival rate for these patients. Fluorescence spectroscopy is a noninvasive diagnostic tool that can aid in real-time cancer detection, with the potential to provide similar sensitivity and specificity to that of the clinical diagnoses of experienced professionals. It is a relatively simple, fast and accurate technique that assesses the biochemical composition and structure of the tissue by the fluorescence spectrum emitted after the application of a beam of light. When there is progression from a normal state to an altered state, this is reflected in the spectral characteristics of the fluorescence of the tissues, which may be correlated with the histopathological examination of these tissues. The aim of this study was to discriminate, in oral mucosa, healthy tissue through fluorescence spectroscopy by evaluating surgically resected margins. Assessments occurred in patients of the Head and Neck Surgery and Otorhinolaryngology Department of A.C. Camargo Cancer Center. The study was approved by the Research Ethics Committee of the institution. The sample consisted of 75 individuals who underwent fluorescence spectroscopy, of which there were 45 individuals with oral carcinoma and 30 healthy volunteers with normal oral mucosa. Twenty-nine cases (64.4%) were male and the mean age was 61.3 years. Biopsies were performed and the results of these two methods were compared using histopathology as the gold standard to identify spectral characteristics from clinically unchanged tissues to surgical margins of the mucosa of volunteers. The spectra were classified and compared with histopathology for determining the efficiency of diagnostic discrimination of employing fluorescence. The initial analysis was qualitative and consisted of following mathematical processing of the spectra with excitation in lengths of 532 and 406 nm. Variability was observed among individuals, anatomical sites, regions of the same lesion and clinically normal tissue of volunteers and the tissue of surgical margins in situ. Also observed were large differences between spectra in situ and ex vivo, in agreement with results of other studies. The accuracy of the technique varied according to the type of analysis used, but its potential use is noted as an aid to evaluated surgical margins in oral cancer
Doutorado
Estomatologia
Doutora em Estomatopatologia
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Abrahim, Naíza Menezes Medeiros, and 92-99962-0222. "Contribuição da Citopatologia Esfoliativa no diagnóstico de lesões de cavidade oral." Universidade Federal do Amazonas, 2017. https://tede.ufam.edu.br/handle/tede/6331.

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JUSTIFICATION: Oral cancer is considered worldwide as a major public health problem, more common in developing countries. The evolution can be insidious, and often diagnosed only in advanced stages with mutilating surgeries, associated or not with adjuvant treatment. As in other cancers, early diagnosis is a priority activity to perform less aggressive treatments and improving survival. An activity that can contribute to the early diagnosis of lesions with or without evident clinical repercussion is exfoliative cytology; technique is not yet implemented for the diagnosis of oral lesions in the Amazonas´s state. OBJECTIVES: The aim of this study is to evaluate the efficacy of the use of exfoliative cytology for the diagnosis of oral cavity and oropharyngeal lesions, prior to its surgical removal. MATERIAL AND METHODS: Patients with an incisional or excisional biopsy of oral cavity lesions attended at the Dental North Specialty Center and the Oncology Control Center Foundation of the State of Amazonas, both in Manaus-AM, were selected. Before completing the biopsy, and after patient's consent, a form was filled out to obtain clinical data, followed by photodocumentation of the lesion and collection of cytological material for the preparation of conventional smears and in a liquid medium. These were fixed and then stained by the Papanicolaou technique. The results of the cytology techniques were compared with each other and with those obtained in the histopathological evaluation. RESULTS: The study sample was composed of 50 patients, 30 females and 20 males. In 70% of the cases, the lesions were histological interpreted as benign and 30% as malignant. Squamous cell carcinoma was the most prevalent lesions, with 15 cases, the benign lesions preferential site was lip and the malignant lesions were tongue, the profile´s patients diagnosed with malignancy was of male patients, smoker and alcohol use. When comparing the two methods of cytology we obtained 100% sensitivity, specificity 97%, accuracy 97%, Kappa 0.91. Regarding the accuracy of the cytological and histopathological diagnosis, sensitivity was 86.6%, specificity 100%, PPV 100%, NPV 94.5%, Kappa 0.958 and accuracy 96%. CONCLUSIONS Traditional and liquid based cytology methods were able to identify and classify cell changes with characteristics of malignancy and have high sensitivity and specificity, without significant differences between the two techniques tested. Cytology techniques have proven reproducible and, if well indicated, can be routinely used for the early detection of malignant lesions.
JUSTIFICATIVA: O câncer de boca é considerado em todo o mundo como um grave problema de saúde pública, sendo mais incidente em países em desenvolvimento. Sua evolução pode ser insidiosa, sendo na maioria das vezes diagnosticado apenas em estágios avançados, em que cirurgias mutiladoras são realizadas, associadas ou não a tratamento adjuvante. Como em outras neoplasias, a precocidade do diagnóstico é atividade prioritária para a realização de tratamentos menos agressivos e na melhoria da sobrevida. Uma atividade que pode contribuir para o diagnóstico precoce de lesões orais e de orofaringe, com ou sem repercussão clínica mais evidente, é a citologia esfoliativa, técnica ainda não implementada para avaliação das referidas lesões no Estado do Amazonas. OBJETIVOS: Avaliar a eficácia do uso da citopatologia esfoliativa para diagnóstico de lesões de cavidade oral antes de sua remoção cirúrgica. MÉTODOS: Foram selecionados pacientes com indicação de biópsia incisional ou excisional de lesões de cavidade oral e orofaringe, atendidos no Centro de Especialidade Odontológica Norte e na Fundação Centro de Controle de Oncologia do Estado do Amazonas, ambos em Manaus-AM. Antes da realização da biópsia, e após anuência do paciente, foi realizado preenchimento de formulário para obtenção de dados clínicos, seguido de fotodocumentação da lesão e de coleta de material citológico para confecção de esfregaços convencional e em meio líquido. Estes foram fixados e então corados pela técnica de Papanicolau. Os resultados das técnicas de citologia foram comparados entre si e com aqueles obtidos na avaliação histopatológica. RESULTADOS: A amostra foi constituída de 50 pacientes, na qual 30 eram do sexo feminino e 20 do sexo masculino. E em 70% dos casos a lesão foi interpretada à histopatologia como de natureza benigna e em 30%, como maligna. A localização preferencial das lesões benignas foi em lábio e das lesões malignas, em língua, sendo que destas, a mais prevalente foi o carcinoma escamocelular, com 15 casos. O perfil dos pacientes com diagnóstico de malignidade foi de pacientes do sexo masculino, tabagistas e etilistas. Quando os dois métodos de citologia foram comparados entre si foram obtidos os seguintes resultados: sensibilidade 100%, especificidade 97%, acurácia 97%, Kappa 0,91. Com relação à acuidade do diagnóstico citológico com o histopatológico, a sensibilidade foi de 86,6%, a especificidade de 100%, o VPP 100%, o VPN 94,5%, Kappa 0,958 e acurácia 96%. CONCLUSÕES: Os métodos de citologia tradicional e em meio líquido foi capaz de identificar e classificar as alterações celulares características de malignidade e possuem alta sensibilidade e especificidade, sem que houvesse diferenças significativas entre as duas técnicas testadas. As técnicas de citologia se mostraram reprodutíveis e se bem indicadas podem ser utilizadas rotineiramente para detecção precoce de lesões malignas.
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Leimert, Mario, Tareq A. Juratli, Claudia Lindner, Kathrin D. Geiger, Johannes Gerber, Gabriele Schackert, and Matthias Kirsch. "An Extremely Rare, Remote Intracerebral Metastasis of Oral Cavity Cancer: A Case Report." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-132102.

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Distant brain metastases from oral squamous cell carcinomas (OSCC) are extremely rare. Here we describe a case of a 53-year-old man with a primary OSCC who referred to the neurosurgical department because of epileptic seizures. MR imaging revealed an enhancing lesion in the right parietal lobe. A craniotomy with tumor removing was performed. Histopathological examination verified an invasive, minimally differentiated metastasis of the primary OSCC. The patient refused whole brain radiation therapy and died from pulmonary metastatic disease 10 months after the neurosurgical intervention without any cerebral recurrence. To the authors’ knowledge, only two similar cases have been previously reported.
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Books on the topic "Squamous cell carcinoma of the oral cavity"

1

Thankappan, Krishnakumar. Per Oral Resection of Oral Tongue Squamous Cell Carcinoma. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6065-1.

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Oral cancer metastasis. New York: Springer, 2010.

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Worrall, Stephen Frederick. An investigation into the association between cytochrome P450 and glutathione S-transferase detoxification enzyme polymorphisms and human oral squamous cell carcinoma. Birmingham: University of Birmingham, 1998.

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Thun, Michael J., and Neal D. Freedman. Tobacco. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0011.

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Tobacco is the leading preventable cause of cancer and other non-communicable diseases worldwide. IARC and the U.S. Surgeon General designate over twenty cancer sites or subsites as causally related to active cigarette smoking, including lung, oral cavity, nasal cavity and accessory sinuses, naso- oro- and hypopharynx, larynx, esophagus (squamous cell carcinoma and adenocarcinoma), stomach, pancreas, colorectum, liver, kidney (adeno- and transitional cell carcinoma), ureter, urinary bladder, uterine cervix, ovary (mucinous), and acute myeloid leukemia. Even this list may be incomplete, as it does not include sites for which the evidence is still considered limited, such as advanced prostate cancer and breast cancer. In addition to cigarettes, all other forms of smoked and conventional smokeless tobacco products, as well as involuntary exposure to tobacco smoke, cause cancer. The use of multiple tobacco products continues to complicate tobacco control, as does the recent introduction of novel products such as e-cigarettes.
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Vatsa, Dr Ritesh, Dr Jay Kishore, and Dr Shubham Kumar, eds. Oral Squamous Cell Carcinoma. AkiNik Publications, 2020. http://dx.doi.org/10.22271/ed.book.956.

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Murphy, Barbara A., Lauren A. Zatarain, Anthony J. Cmelak, Steven Bayles, Ellie Dowling, Cheryl R. Billante, Sheila Ridner, et al. Palliative issues in the care of patients with cancer of the head and neck. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0145.

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Head and neck cancer (HNC) refers to tumours arising from the epithelial lining of the upper aerodigestive track, including the oral cavity, larynx, pharynx, paranasal sinuses, and salivary glands. There are 50,000 cases of HNC diagnosed annually within the United States. The majority of tumours (> 90%) are squamous cell carcinomas. Risk factors include tobacco, alcohol, and areca nuts; human papilloma virus (HPV) or Epstein-Barr virus; and mucosal irritation. Previously considered to be a disease of older adults, the epidemic of HPV-associated oropharyngeal cancers has led to a striking increase in HNC among middle-aged adults. Symptoms are usually present at the time of diagnosis and remain problematic through the terminal phase. For those patients who are cured, long-term biopsychosocial sequelae may persist for years. Thus, assessment and treatment of palliative issues is an intrinsic and vital component of care for the HNC patient.
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Black, Riva. Oral papillary squamous cell carcinoma: Its relation to human papillomavirus infection and associated cell cycle deregulation. 2005.

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L, Nielsen Frederik, ed. Progress in oral cancer research. New York: Nova Biomedical Books, 2008.

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Nielsen, Frederik L. Progress in Oral Cancer Research. Nova Science Pub Inc, 2007.

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Myers, Jeffrey. Oral Cancer Metastasis. Springer, 2014.

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Book chapters on the topic "Squamous cell carcinoma of the oral cavity"

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Agbetoba, Abib A., and Brett A. Miles. "Oral Cavity and Oropharyngeal Squamous Cell Carcinoma." In ENT Board Prep, 235–46. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8354-0_21.

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Bier, J. "Radical Neck Dissection Versus Conservative Neck Dissection for Squamous Cell Carcinoma of the Oral Cavity." In Carcinoma of the Oral Cavity and Oropharynx, 57–62. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84971-8_7.

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Wolf, G. T., S. Urba, and M. Hazuka. "Induction Chemotherapy for Organ Preservation in Advanced Squamous Cell Carcinoma of the Oral Cavity and Oropharynx." In Carcinoma of the Oral Cavity and Oropharynx, 133–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84971-8_15.

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Boysen, M. "Value of Follow-Up in Patients Treated for Squamous Cell Carcinomas of the Oral Cavity and Oropharynx." In Carcinoma of the Oral Cavity and Oropharynx, 205–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84971-8_23.

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Mehta, Sushma, and Moni Abraham Kuriakose. "Principles of Surgical Management of Oral Cancer." In Oral and Maxillofacial Surgery for the Clinician, 1869–91. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_82.

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AbstractOral Cavity Squamous Cell Carcinoma (OSCC), is a heterogenous disease with respect to risk factors, geographic predelictions, treatment response and outcome. Although non-surgical treatment is employed in other head and neck sub-sites, surgery is the primary treatment modality to treat oral cancers followed by adjuvant treatment either in the form of radiation or chemoradiation based on the risk features on final histopathology. It is utmost importance that all the patients before undergo treatment are discussed and treatment plan is formulated in a multidisciplinary tumor board. This chapter intent to elaborate the basic surgical principles involved in management of different sub-sites of oral cavity as well as reconstruction of the defects.
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Mazeron, J. J., L. Grimard, and V. Benk. "Curietherapy Versus External Irradiation Combined with Curietherapy in Stage II Squamous Cell Carcinomas of Mobile Tongue and Floor of Mouth." In Carcinoma of the Oral Cavity and Oropharynx, 101–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-84971-8_12.

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Ross Kerr, A. "Diagnostic Adjuncts for Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders." In Textbook of Oral Cancer, 99–117. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-32316-5_9.

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Chinn, Steven B., and Stephen Y. Lai. "Role and Efficacy of Sentinel Lymph Node Biopsy in Oral Cavity Squamous Cell Carcinoma." In Difficult Decisions in Surgery: An Evidence-Based Approach, 51–64. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-15123-2_6.

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Bhat, Venkatraman, and H. V. Sunil. "Imaging in Malignancy of the Oral Cavity and Role of PET CT in Squamous Cell Carcinoma of Head and Neck Region." In Contemporary Oral Oncology, 23–77. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-14917-2_2.

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Ulla, A., and J. Pikani. "Neoadjuvant Chemotherapy in Previously Untreated Patients with Advanced Oral Cavity and Pharyngeal Squamous Cell Carcinoma." In Teil II: Sitzungsbericht, 172–73. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-84310-5_166.

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Conference papers on the topic "Squamous cell carcinoma of the oral cavity"

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Won, Hye Sung, Ji Hyung Hong, Eun Kyoung Jeon, Yoon Ho Ko, Sang Hoon Chun, Chan-Kwon Jung, and Jin-Hyoung Kang. "Abstract B21: The difference in the role of PI3K/Akt/mTOR pathway between oropharyngeal squamous cell carcinoma and oral cavity squamous cell carcinoma." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-b21.

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Hsieh, Ling-Ling, Chih-Hsiung Lai, Shiang-Fu Huang, Chun-Ta Liao, I.-How Chen, and Hung-Ming Wang. "Abstract 2009: Clinical value of pathogenic mitochondrial mutations in oral cavity squamous cell carcinoma." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2009.

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Hsueh, Pei Chun, and Chih Ching Wu. "Abstract 1148: Salivary auto-antibodies as diagnostic markers of oral cavity squamous cell carcinoma." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-1148.

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Hu, Yaogai, Tao Jiang, and Zhengyu Zhao. "Discrimination of Squamous Cell Carcinoma of the Oral Cavity Using Raman Spectroscopy and Chemometric Analysis." In 2008 First International Conference on Intelligent Networks and Intelligent Systems (ICINIS). IEEE, 2008. http://dx.doi.org/10.1109/icinis.2008.61.

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Campbell, Katie M., Tianxiang Lin, Ashley E. Winkler, Paul Zolkind, Zachary L. Skidmore, Erica K. Barnell, Ian Hagemann, et al. "Abstract 3847: Oral cavity squamous cell carcinoma xenografts display conservation of primary tumor genomic heterogeneity." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3847.

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Koo, Kendrick, Christopher Angel, Nadia Kershaw, Dmitri Mouradov, Anderly Chueh, David Wiesenfeld, Tim A. Iseli, Michael McCullough, Oliver Sieber, and Antony W. Burgess. "Abstract A01: Characterization of NOTCH1 mutations in oral cavity squamous cell carcinomas." In Abstracts: AACR Special Conference on Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy; October 27-30, 2016; San Francisco, CA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.transcontrol16-a01.

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Tang, Xiao-Han, Theresa Scognamiglio, and Lorraine Gudas. "Abstract 3036: Basal stem cells contribute to squamous cell carcinomas in the oral cavity." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3036.

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Hu, Yaogai, Zhengyu Zhao, and Tao Jiang. "Classification of Squamous Cell Carcinoma of the Oral Cavity Using Wavelet Analysis and BP-Chaos Networks." In 2009 First International Conference on Information Science and Engineering. IEEE, 2009. http://dx.doi.org/10.1109/icise.2009.393.

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Chang, Kai-Ping, Ting-Wen Chen, Curtis R. Pickering, Jeffrey N. Myers, and Yu-Sun Chang. "Abstract IA10: Integrated omics analyses identify prognostic biomarkers of oral cavity squamous cell carcinoma in Taiwan." In Abstracts: AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3265.aacrahns17-ia10.

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Hu, Yaogai, Zhengyu Zhao, and Tao Jiang. "Discrimination of Squamous Cell Carcinoma of the Oral Cavity Using Confocal Raman Microspectroscopy and BP-Chaos Networks." In 2009 International Conference on Computational Intelligence and Software Engineering. IEEE, 2009. http://dx.doi.org/10.1109/cise.2009.5366214.

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Reports on the topic "Squamous cell carcinoma of the oral cavity"

1

Wang, Dong, XiaoJie Duan, Yuhui Zhang, Zhen Meng, and Jing Wang. Traditional Chinese medicine for oral squamous cell carcinoma: A Bayesian network meta-analysis protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2020. http://dx.doi.org/10.37766/inplasy2020.9.0082.

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Wang, Mingfei, Linfeng Zhang, Wenhao Ren, Shaoming Li, Keqian Zhi, Jingjing Zheng, and Ling Gao. Diagnostic Value of CircRNAs as Potential Biomarker in Oral Squamous Cell Carcinoma: A Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0037.

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3

Kloss-Brandstatter, A., G. Erhart, H. Weissensteiner, G. Schafer, L. Forer, S. Schonherr, D. Pacher, et al. Somatic mitochondrial DNA mutations are associated with progression, metastasis and death in oral squamous cell carcinoma. Cold Spring Harbor Laboratory, January 2014. http://dx.doi.org/10.1101/002055.

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