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Journal articles on the topic 'Squamous cell carcinoma of the oral cavity'

Author: Grafiati

Published: 8 September 2021

Last updated: 13 February 2022

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1

Bewley, Arnaud F., and D. Gregory Farwell. "Oral leukoplakia and oral cavity squamous cell carcinoma." Clinics in Dermatology 35, no. 5 (September 2017): 461–67. http://dx.doi.org/10.1016/j.clindermatol.2017.06.008.

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2

Odukoya, Onatolu, Adeyemi Mosadomi, Danny R. Sawyer, Adenike Orejobi, and Ayo Kekere-Ekun. "Squamous cell carcinoma of the oral cavity." Journal of Maxillofacial Surgery 14 (January 1986): 267–69. http://dx.doi.org/10.1016/s0301-0503(86)80302-2.

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3

Aulino, Joseph M., Megan K. Strother, and Jason L. Shipman. "Imaging of Oral Cavity Squamous Cell Carcinoma." Oral and Maxillofacial Surgery Clinics of North America 18, no. 4 (November 2006): 445–63. http://dx.doi.org/10.1016/j.coms.2006.06.011.

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4

Howard, Adam, Nishant Agrawal, and Zhen Gooi. "Lip and Oral Cavity Squamous Cell Carcinoma." Hematology/Oncology Clinics of North America 35, no. 5 (October 2021): 895–911. http://dx.doi.org/10.1016/j.hoc.2021.05.003.

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5

Markopoulos, Anastasios K. "Current Aspects on Oral Squamous Cell Carcinoma." Open Dentistry Journal 6, no. 1 (August 10, 2012): 126–30. http://dx.doi.org/10.2174/1874210601206010126.

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Oral squamous cell carcinoma is the most common malignant epithelial neoplasm affecting the oral cavity. This article overviews the essential points of oral squamous cell carcinoma, highlighting its risk and genomic factors, the potential malignant disorders and the therapeutic approaches. It also emphasizes the importance of the early diagnosis.

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6

Kintawati, Silvi. "Corellation of p53 expressions and histopathological grading in oral cavity squamous cell carcinoma." Dental Journal (Majalah Kedokteran Gigi) 49, no. 3 (September 30, 2016): 120. http://dx.doi.org/10.20473/j.djmkg.v49.i3.p120-124.

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Background: Squamous cell carcinoma is a malignancy of oral cavity mostly occurred and can also metastasize. p53 gene is a tumor suppressor gene that plays an important role in carcinogenesis. The role of wild-type p53 is very important in suppressing the formation of a malignancy. p53 also has many other important functions. p53 is a suppressor of tumor/ cancer progression through the response of cell cycle to DNA damage and by giving time to repair DNA prior to replication of genes. p53 mutation, mostly occurs in a malignancy, so earlier histopathological transformation can be detected by observing p53 mutation. The prognosis of squamous cell carcinoma in oral cavity, therefore, depends on histopathological grading and clinical staging of the tumor. To enforce the histopathological grading, in addition based on histopathology differentiation, the earlier histopathological transformation can also be assessed. Purpose: This study aimed to determine the correlation of p53 expressions and histopathological grading in oral cavity squamous cell carcinoma. Method: This study was a retrospective study on 20 cases of oral cavity squamous cell carcinoma examined at Department of Pathology Anatomy in Hasan Sadikin Hospital in Bandung. Immunohistochemical examination was then performed using p53 antibodies to determine the correlation of p53 expression and histopathological grading in oral cavity squamous cell carcinoma to predict prognosis. Result: The overall results showed that there was no correlation between p53 expression and histopathological grading in oral cavity squamous cell carcinoma of the oral cavity although there was a very strong correlation between p53 expression and histopathological grading I (p<0.01). Conclusion: It can be concluded that there was no correlation between p53 expression and histopathological grading in oral cavity squamous cell carcinoma. Thus, p53 expression cannot be used to predict a prognosis.

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7

Patni, Parth, Deepak Dalmia, Narsinha Davange, Karthika Bhagavan, Amit Palwade, and Rizul Goyal. "Level IIb involvement in oral cavity squamous cell carcinoma." International Journal of Otorhinolaryngology and Head and Neck Surgery 7, no. 2 (January 25, 2021): 292. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20210159.

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<p><strong>Background:</strong> Cervical lymph node status is the most significant prognostic factor in the treatment of patients with OSCC. Adequate clearance of level IIb lymph nodes require traction and elevation of the spinal accessory nerve (SAN) and can lead to consequent shoulder problems.Therefore, avoiding the dissection of level IIb has been increasingly proposed to overcome this complication. The aim of this study was to determine the prevalence of level IIb metastasis in patients with oral squamous cell carcinomas (OSCCs).</p><p><strong>Methods: </strong>A total of 106 newly diagnosed oral cavity cancer patients requiring surgery as the primary modality were included in the study. Preoperative clinical examinations were done and tumor-node-metastasis staging was noted. Intraoperative, level IIb nodal tissue was dissected and sent separately.</p><p><strong>Results: </strong>A total of 106 neck dissections were done out of which male: female ratio of 2.78:1. 49.05% patients were suffering from buccal mucosa carcinoma followed by tongue carcinoma (22.64%). 52.83% of patients had no neck involvement. Among neck positive cases, pN1 was the most common presentation. Out of these, only 8 (7.54%) neck dissections had level IIb positive.</p><p><strong>Conclusions: </strong>Dissection of the level IIb region in patients with OSCC may be required only in cases with advanced N stage, positive level IIa lymph nodes, and extra capsular spread. Further evaluation can be done among various subsites of OSCC, clinical staging of tumour, occult bilateral nodal metastasis to assess the need of resection of level IIb in OSCC.</p>

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8

Tan, Marietta, Jeffrey N. Myers, and Nishant Agrawal. "Oral Cavity and Oropharyngeal Squamous Cell Carcinoma Genomics." Otolaryngologic Clinics of North America 46, no. 4 (August 2013): 545–66. http://dx.doi.org/10.1016/j.otc.2013.04.001.

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9

Chen, T. M., J. T. Chang, I. H. Chen, C. J. Kang, and C. T. Liao. "111 Early stage oral cavity squamous cell carcinoma." European Journal of Cancer Supplements 1, no. 5 (September 2003): S38. http://dx.doi.org/10.1016/s1359-6349(03)90144-3.

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10

DOS SANTOS, HELENA AYRES ALONSO, RAFFAEL MARON, ELLEN BRILHANTE CORTEZZI, BRUNO AUGUSTO BENEVENUTO DE ANDRADE, MÁRIO JOSÉ ROMAÑACH, and MICHELLE AGOSTINI. "ACANTHOLYTIC SQUAMOUS CELL CARCINOMA OF THE ORAL CAVITY." Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 129, no. 1 (January 2020): e71. http://dx.doi.org/10.1016/j.oooo.2019.06.279.

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11

Crombie, Anthony K., Camile Farah, Lee Tripcony, Graeme Dickie, and Martin D. Batstone. "Primary chemoradiotherapy for oral cavity squamous cell carcinoma." Oral Oncology 48, no. 10 (October 2012): 1014–18. http://dx.doi.org/10.1016/j.oraloncology.2012.03.027.

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12

Hsu, Phillip J., Kenneth Yan, Hailing Shi, Evgeny Izumchenko, and Nishant Agrawal. "Molecular biology of oral cavity squamous cell carcinoma." Oral Oncology 102 (March 2020): 104552. http://dx.doi.org/10.1016/j.oraloncology.2019.104552.

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13

Kupferman, Michael E., and Jeffrey N. Myers. "Molecular Biology of Oral Cavity Squamous Cell Carcinoma." Otolaryngologic Clinics of North America 39, no. 2 (April 2006): 229–47. http://dx.doi.org/10.1016/j.otc.2005.11.003.

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14

Bradford, Jennifer. "SP212 – Oral cavity squamous cell carcinoma post-transplantation." Otolaryngology - Head and Neck Surgery 141, no. 3 (September 2009): P159—P160. http://dx.doi.org/10.1016/j.otohns.2009.06.509.

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15

Trott, Kiley E., Jenna W. Briddell, Diana Corao-Uribe, Jonathan Powell, Olivia M. Seecof, Carly Levy, Elissa G. Miller, and Udayan K. Shah. "Dyskeratosis Congenita and Oral Cavity Squamous Cell Carcinoma." Journal of Pediatric Hematology/Oncology 41, no. 6 (August 2019): 501–3. http://dx.doi.org/10.1097/mph.0000000000001478.

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16

Lin, Wei-Hung, I.-How Chen, Fu-Chan Wei, Jung-Ju Huang, Chung-Jan Kang, Ling-Ling Hsieh, Hung-Ming Wang, and Shiang-Fu Huang. "Clinical significance of preoperative squamous cell carcinoma antigen in oral-cavity squamous cell carcinoma." Laryngoscope 121, no. 5 (April 25, 2011): 971–77. http://dx.doi.org/10.1002/lary.21721.

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17

Salavadi, Shyam Sunder, Srinu Sabavath, Ganesh Ganji, and •. Samanvitha Sunkari. "Gingival Squamous Cell Carcinoma: A Missed Diagnosis." Journal of Periodontology & Implant Dentistry 9, no. 1 (October 9, 2017): 26–28. http://dx.doi.org/10.15171/jpid.2017.005.

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Squamous cell carcinoma (SCC) is one of the most common epithelial malignancies affecting the oral cavity with different clinical presentations. Carcinomas of the gingiva constitute approximately 10% of OSCCs and can mimic reactive, inflammatory conditions of the gingiva, leading to a diagnostic delay. Therefore it is of great importance to diagnose the lesion early for good prognosis. This article reports a rare case of gingival OSCC in a 39-year-old male patient mimicking an inflammatory gingival mass.

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18

Naidu, T. K., S. K. Naidoo, and P. K. Ramdial. "Oral cavity squamous cell carcinoma metastasis to the submandibular gland." Journal of Laryngology & Otology 126, no. 3 (October 13, 2011): 279–84. http://dx.doi.org/10.1017/s0022215111002660.

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AbstractIntroduction:This study aimed to evaluate the incidence of submandibular gland metastases in cases of oral cavity squamous cell carcinoma.Methods:Sixty-nine patients treated between 1 January 2004 and 30 June 2009 were retrospectively reviewed. Patients were treated with wide local excision of the primary tumour, plus simultaneous neck dissection and reconstruction if required.Results:Of 69 submandibular glands from 46 men and 23 women (mean age, 58 years), 43 (62.3 per cent) had advanced, tumour stage three or four lesions. Histopathological reappraisal of all submandibular glands demonstrated an absence of metastatic spread. Only 2/69 (2.9 per cent) submandibular glands demonstrated ipsilateral contiguous tumour involvement.Conclusion:This study demonstrated an absence of metastasis to the submandibular gland from oral cavity squamous cell carcinoma. Patients with early stage oral cavity squamous cell carcinoma and with a pre-operative node stage zero neck may be candidates for preservation of the submandibular gland during neck dissection.

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19

Buim, M., C. P. Nagano, S. V. Lourenço, J. H. Fregnani, A. L. Carvalho, and F. A. Soares. "Cell cycle proteins in squamous cell carcinoma of oral cavity." European Journal of Cancer Supplements 6, no. 9 (July 2008): 55. http://dx.doi.org/10.1016/s1359-6349(08)71385-5.

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20

Chi, Angela C., Terry A. Day, and Brad W. Neville. "Oral cavity and oropharyngeal squamous cell carcinoma-an update." CA: A Cancer Journal for Clinicians 65, no. 5 (July 27, 2015): 401–21. http://dx.doi.org/10.3322/caac.21293.

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21

Olsen, S. M., E. J. Moore, K. D. Olsen, C. A. Koch, and J. L. Kasperbauer. "P1.23. Parotid metastases from oral cavity squamous cell carcinoma." Oral Oncology Supplement 3, no. 1 (July 2009): 130. http://dx.doi.org/10.1016/j.oos.2009.06.309.

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22

Bishop, Justin A., James J. Sciubba, and William H. Westra. "Squamous Cell Carcinoma of the Oral Cavity and Oropharynx." Surgical Pathology Clinics 4, no. 4 (December 2011): 1127–51. http://dx.doi.org/10.1016/j.path.2011.07.002.

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23

Altavilla, Giuseppe, Giacinto M. Mannarà, Alessandra Rinaldo, and Alfio Ferlito. "Basaloid Squamous Cell Carcinoma of Oral Cavity and Oropharynx." ORL 61, no. 3 (1999): 169–73. http://dx.doi.org/10.1159/000027665.

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24

Brown, Kevin S., and Madeleine A. Kane. "Chemoprevention of squamous cell carcinoma of the oral cavity." Otolaryngologic Clinics of North America 39, no. 2 (April 2006): 349–63. http://dx.doi.org/10.1016/j.otc.2005.11.010.

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25

Rudmik, Luke, and Joseph Dort. "SP235 – Molecular evaluation of oral cavity squamous cell carcinoma." Otolaryngology - Head and Neck Surgery 141, no. 3 (September 2009): P158. http://dx.doi.org/10.1016/j.otohns.2009.06.505.

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26

Liao, Chun-Ta, Joseph Tung-Chieh Chang, Hung-Ming Wang, Shu-Hang Ng, Chuen Hsueh, Li-Yu Lee, Chih-Hung Lin, et al. "Survival in squamous cell carcinoma of the oral cavity." Cancer 110, no. 3 (2007): 564–71. http://dx.doi.org/10.1002/cncr.22814.

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27

Kusafuka, Kimihde, Mitsuru Ebihara, Hiroto Ishiki, Yoshinori Takizawa, Yoshiyuki Iida, Tetsuro Onitsuka, Reiko Takakuwa, Masako Kasami, Ichiro Ito, and Toru Kameya. "Primary adenoid squamous cell carcinoma of the oral cavity." Pathology International 56, no. 2 (February 2006): 78–83. http://dx.doi.org/10.1111/j.1440-1827.2006.01927.x.

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28

Patil, Seema, Manmita Das, Asha R. Iyengar, Subash B.V, Ritika Agarwal, and Aparna S. Namboothiri. "GINGIVAL SQUAMOUS CELL CARCINOMA- A CASE REPORT." International Journal of Advanced Research 8, no. 11 (November 30, 2020): 548–53. http://dx.doi.org/10.21474/ijar01/12040.

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Gingival squamous cell carcinoma (GSCC) is a relatively rare malignant neoplasm of the oral cavity. It represents less than 4-6.3% of diagnosed intraoral carcinomas. GSCC may cause odontogenic symptoms such as mobility and pain of teeth mimicking inflammatory conditions such as periodontitis. Early diagnosis and prompt management of GSCC is of paramount importance as the prognosis of gingival squamous cell carcinoma is mainly dependent on these factors. Further, as, GSCCs spread rapidly to involve the underlying bone, the role of dentists in early detection of gingival squamous cell carcinoma cannot be undermined. The present report describes a rare case of GSCC in a 31 year old male. The detailed recording of the case history and clinical examination, radiographic, and laboratory investigations, along with review of similar conditions led to the diagnosis, and treatment was initiated.

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29

Tamtaji, Omid Reza, Moein Mobini, Amir Abbas Atlasi, Ehsan Dadgostar, and Zatollah Asemi. "Melatonin and oral squamous cell carcinoma: current knowledge and future perspectives." Melatonin Research 2, no. 1 (February 16, 2019): 94–105. http://dx.doi.org/10.32794/mr11250013.

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On the basis of worldwide ranking, oral cancer is the eighth most prevalent cancer. Oral squamous cell carcinoma is a cancer that occurs following dysplasia of the mucosa of the oral cavity and oropharynx. There are different inflammatory pathways involved in the pathophysiology of oral squamous cell carcinoma. Melatonin (N-acetyl-5-methoxytryptamine), a well documented anticancer agent, exhibits numerous functions including induction of apoptotic pathways and controlling of oxidative stress. In the in vivo and in vitro studies the results have demonstrated that melatonin supplementation is an appropriate therapeutic approach for oral squamous cell carcinoma. Melatonin might inhibit cancer cells through the regulation of molecular pathways including AKT/mTOR pathway, ERK/AKT signaling, LSD1 expression and tumor-associated neutrophils releasing. Limited clinical studies; however, have evaluated the role of melatonin in oral squamous cell carcinoma. This review summarizes current knowledge and evidence regarding the effects of melatonin on oral squamous cell carcinoma and the mechanisms involved.

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30

Caponio, Troiano, Mascitti, Santarelli, Mauceri, and Lo Muzio. "Predicting Death in Patients with Squamous Cell Carcinoma of the Tongue." Proceedings 35, no. 1 (December 10, 2019): 18. http://dx.doi.org/10.3390/proceedings2019035018.

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Tongue squamous cell carcinoma (TSCC) accounts for 40% of all squamous cell carcinoma involving the mucosal surface of the oral cavity. TSCC is highly invasive and aggressive and, nowadays, TNM staging system is considered the gold standard in predicting patients’ outcomes. [...]

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31

Sultana, N., Q. B. Rahman, S. Alam, Md M. Karim, and Md F. Kabir. "Effect of Neoadjuvant Chemotherapy on the Size of Lesion in Oral Squamous Cell Carcinoma." Journal of Medical Science & Research 21, Number 2 (July 1, 2013): 9–17. http://dx.doi.org/10.47648/jmsr.2013.v2102.02.

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A prospective randomized trial was performed to evaluate the combination of neoadjuvant chemotherapy in patient with oral squamous cell carcinoma. Prognosis of patient with squamous cell carcinoma in oral cavity is worth improving. Chemotherapy has been reported specially active in oral cavity tumour. It has been enrolling patients with stage T2, T3, T4 NO NI N2 MO untreated squamous cell carcinoma in oral cavity. Number of patients in this study was 25, suffering from squamous cell carcinoma. This study was a Prospective study conducted among the randomly selected 25 cases of histopathologically diagnosed Squamous cell carcinoma patients from the Department of Oral and Maxillofacial surgery Bangabandhu Sheikh Mujib Medical University and Department of Oncology Bangabandhu Shiekh Mujib Medical university . Both male and female were included and assigned for three cycles of cisplatin and 5fluorouracil followed by definitive treatment. The study was done between January 2007 to December 2008. 25 patients were included in this study, 21.7% patients showed complete response and 84.2% showed partial response. Out of 25, 20.0% patients mouth opening were reduced and 4.0% patients mouth opening were improved. After taking computed tomography all patient showed tumour progression. Histopathologically only 1 patient showed complete response among 25 which is not signcant. Neoadjuvant chemotherapy reduced the size of the lesion clinically. Results down staging of the tumour but histologically it was not given any significant changes. So probably neoadjuvant chemotherapy is unable to fulfill our desire expectation.

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32

Dai, Liyuan, Qigen Fang, Peng Li, Junfu Wu, and Xu Zhang. "Secondary Squamous Cell Carcinoma of the Oral Cavity after Nasopharyngeal Carcinoma." Cancer Research and Treatment 52, no. 1 (January 15, 2020): 109–16. http://dx.doi.org/10.4143/crt.2019.202.

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33

Lim, R. S., L. Evans, A. P. George, N. de Alwis, P. Stimpson, S. Merriel, C. E. B. Giddings, et al. "Do demographics and tumour-related factors affect nodal yield at neck dissection? A retrospective cohort study." Journal of Laryngology & Otology 131, S1 (October 27, 2016): S36—S40. http://dx.doi.org/10.1017/s0022215116009208.

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AbstractBackground:Nodal metastasis is an important prognostic factor in head and neck squamous cell carcinoma. This study aimed to determine the average nodal basin yield per level of neck dissection, and to investigate if age, gender, body mass index, tumour size, depth of tumour invasion and p16 status influence nodal yield.Method:A retrospective review of 185 patients with head and neck squamous cell carcinoma generated 240 neck dissection specimens.Results:The respective mean nodal yields for levels I, II, III, IV and V were 5.27, 9.43, 8.49, 7.43 and 9.02 in non-cutaneous squamous cell carcinoma patients, and 4.2, 7.57, 9.65, 4.33 and 12.29 in cutaneous squamous cell carcinoma patients. Multiple regression analysis revealed that p16-positive patients with mucosal squamous cell carcinoma yielded, on average, 2.4 more nodes than their p16-negative peers (p = 0.04, 95 per cent confidence interval = 0.116 to 4.693). This figure was 3.84 (p = 0.008, 95 per cent confidence interval = 1.070 to 6.605) for p16-positive patients with oral cavity squamous cell carcinoma.Conclusion:In mucosal squamous cell carcinoma, p16-positive status significantly influenced nodal yield, with the impact being more pronounced in oral cavity squamous cell carcinoma patients.

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34

CS, Ng, Mohd Razif M. Y, Chew MX, and Suria HMP. "Spindle Cell Carcinoma of Oral Cavity: A Rare Entity." Bangladesh Journal of Medical Science 20, no. 4 (June 18, 2021): 923–25. http://dx.doi.org/10.3329/bjms.v20i4.54154.

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Introduction:Spindle cell carcinomas (SpCC) are a rare variant of squamous cell carcinoma which is rarely encountered in the head and neck. It is also known as“pseudocarcinoma”, “sarcomatoidcarcinoma,” and “carcinosarcoma”.It has an aggressive nature and has poor prognosis despite aggressive treatment. Case report: A 48-year-old lady presented to us with a right painless upper gum swelling which was progressively enlarging for 3 months after tooth extraction. Examination of the oral a fungating mass over the right upper alveolus extending to the right upper gingivolabial sulcus. She was subjected to a debulking palliative to reduce the tumour bulk. The intraoperative samples sent for histopathological examination was reported as SpCC, AJCC (8th edition) stage pT2pN3b. She recovered well after the surgery with quality of life after the surgery. Bangladesh Journal of Medical Science Vol.20(4) 2021 p.923-925

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35

Dr. Sushanta Kumar Singh, Dr. Gayatri Rath, and Dr. Ashok Kumar Panda. "Laminin - A Prognostic Marker in Oral Squamous Cell Carcinoma." International Journal of Innovative Research in Medical Science 6, no. 01 (January 1, 2021): 13–18. http://dx.doi.org/10.23958/ijirms/vol06-i01/1018.

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Introduction: Squamous cell carcinoma is one of the most common malignant tumours of the oral cavity and is the tenth most common cause of death worldwide. Because of the high malignant potentially these cases are detected at an advanced stage. Also the recurrence rate is high which invites challenge to the treating surgeon. Laminin, a basement membrane molecule is a reliable marker to predict dif-ferentiation and aggressiveness of the oral squamous cell carcinomas. Methods: The study was conducted in the department of pathology, S. C B Medical College, Cuttack with an aim to predict the tumour aggressiveness and thereby prognosis. A total number of 76 cases were studied using the laminin immunostaining and the results tabulated and interpreted. Results: Majority were well differentiated squamous cell carcinomas, which showed mild to moderate intra cytoplasmic staining of laminin and an intense staining at the tumour host interface, in contrast to an intense intra cytoplasmic staining in poorly differentiated squamous cell carcinoma cases. Those with lymph node metastasis and involved surgical margins also showed intense intra cytoplasmic laminin staining pointing to a higher grade tumour. Conclusion: Laminin immunostaining is definitely superior to the conventional staining procedures for the as-sessment of tumour aggressiveness and differentiation, intra-operative assessment of tumour excision margins and thus access prognosis. Recent researches highlight on Laminin antibodies, which can be used as specific chemotherapeutic agents, to check the process of tumour growth and invasion.

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Uraguchi, M., M. Morikawa, M. Shirakawa, K. Sanada, and K. Imai. "Activation of WNT Family Expression and Signaling in Squamous Cell Carcinomas of the Oral Cavity." Journal of Dental Research 83, no. 4 (April 2004): 327–32. http://dx.doi.org/10.1177/154405910408300411.

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The WNT family activates an oncogenic signaling mediated through β-catenin and is up-regulated in a variety of malignant neoplasms. The signaling translocates β-catenin into the nucleus and stimulates carcinoma cells in the epithelial-mesenchymal transition (EMT). However, WNT expression and signaling in oral carcinomas have not been examined. The present study focused on unveiling the involvement of WNTs in oral carcinomas, and showed that carcinoma cells express 11 of 19 WNT family members by reverse-transcription/PCR. WNT-expressing carcinoma cells exhibited increased β-catenin levels in the cytoplasmic pool and translocation to the nucleus. The activation state of signaling correlated with the expression of membrane-type 1 matrix metalloproteinase, which degrades territorial matrices in carcinoma invasion. Immunohistochemistry disclosed that WNT3 expression and nuclear localization of β-catenin were predominant in carcinoma cells at the invasive front. These results suggest that enhanced WNT expression and signaling accelerate the progression of carcinomas via activating EMTs and local invasiveness.

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37

Su, Nai-Wen, and Yu-Jen Chen. "Metronomic Therapy in Oral Squamous Cell Carcinoma." Journal of Clinical Medicine 10, no. 13 (June 26, 2021): 2818. http://dx.doi.org/10.3390/jcm10132818.

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Metronomic therapy is characterized by drug administration in a low-dose, repeated, and regular manner without prolonged drug-free interval. The two main anticancer mechanisms of metronomic therapy are antiangiogenesis and immunomodulation, which have been demonstrated in several delicate in vitro and in vivo experiments. In contrast to the traditional maximum tolerated dose (MTD) dosing of chemotherapy, metronomic therapy possesses comparative efficacy but greatlydecreases the incidence and severity of treatment side-effects. Clinical trials of metronomic anticancer treatment have revealed promising results in a variety cancer types and specific patient populations such as the elderly and pediatric malignancies. Oral cavity squamous cell carcinoma (OCSCC) is an important health issue in many areas around the world. Long-term survival is about 50% in locally advanced disease despite having high-intensity treatment combined surgery, radiotherapy, and chemotherapy. In this article, we review and summarize the essence of metronomic therapy and focus on its applications in OCSCC treatment.

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38

Israyani, Israyani, Ayu F. Argadianti, Hening Tuti Hendarti, and Adiastuti E. P. "Managementof squamos cell carcinoma of tongue in young men: case report." Journal of Case Reports in Dental Medicine 1, no. 1 (May 1, 2019): 21. http://dx.doi.org/10.20956/jcrdm.v1i1.95.

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Background: Oral Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, usually affecting individuals over 50 years of age. It rarely occurs in patients who are less than 40 years old. Purpose: This case report aim is to focuses on establishment of diagnosis, differential diagnosis, predisposition, and treatment planning related to the case. Case: This report describes a case of oral squamous cell carcinoma, staged T1N1M0 (stage III), involving the lateral border and ventral surface of the tongue of a 32-year old male patient, with no smoking or drinking habits. Initial tumor presentation was of deep ulceration and intense pain. Case Management: Patient has examination with autofluorence LED light, presence of bacterial growth, and FNA for establised diagnosis. Patient was given chlorine dioxide mouthwash and education for further treatment one of them is tomoterapi. Conclusions: Clinical features of deep ulceration, pain and induration may be a suspicious feature of oral cavity cancer, therefore early diagnosis of oral squamous cell carcinoma determines prognosis.Keywords: malignant, autofluoresence, tomoterap

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39

Wikner, Johannes. "Squamous cell carcinoma of the oral cavity and circulating tumour cells." World Journal of Clinical Oncology 5, no. 2 (2014): 114. http://dx.doi.org/10.5306/wjco.v5.i2.114.

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40

Bubliy, T. D., L. I. Voloshina, and L. I. Dubovaya. "EFFECT OF QUARANTINE ON THE RATE OF DIAGNOSTICS OF ORAL SQUAMOUS CELL CARCINOMA." Ukrainian Dental Almanac, no. 2 (June 29, 2021): 11–14. http://dx.doi.org/10.31718/2409-0255.2.2021.02.

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Oral squamous cell carcinoma is the most prevalent manifestations of malignant tumors in the cranial and cervical regions and they cannot be frequently established until symptoms appear. So there is an urgent need to device methods for the detection of oral premalignant lesions and oral cancer at an early stage in order to improve further patients’ conditions. The whole world was suddenly affected the uncontrolled spread of the coronavirus. All spheres of life were affected, especially medicine. The strict quarantine for 2 months created problems for the patients. Patients who needed dental care they also suffered from it. Dental medical institutions provided only emergency medical care during the period of quarantine restrictions. The planned treatment was postponed until the quarantine restrictions stopped. In fact, the entire population of the country was in a state of significant psycho-emotional stress. This was combined with the state of chronic stress, and influenced the number of cancers. This trend can be traced worldwide. According to the literature, in the United States, squamous cell carcinoma of the oral cavity takes 3% of all cancers in men and 2% in women. The tendency of this disease in people 50 years older observed all over the world, however, the disease occurs in people aged 32-49 years. About 40% of intraoral squamous cell carcinomas begin on the floor of the mouth or on the lateral and ventral surfaces of the tongue. About 38% of all oral squamous cell carcinomas occur on the lower lip; these are usually solar-related cancers on the external surface. The symptoms of this disease in the initial stages are absolutely nonspecific. Many patients do not attach importance to them. Quarantine restrictions on the provision of advisory assistance make this problem of particular relevance. The authors of the article have determined that their goal to attract the attention of dentists and family doctors to the problem of early diagnosis of oncological diseases and oral cancer is enough important nowadays. Early, curable lesions are rarely symptomatic; thus, preventing fatal disease requires early detection by screening. The main goal for such investigations is to attract the attention of dentists and family doctors to the problem of early diagnosis of cancer, including oral cavity. The article presents the clinical characteristics of squamous cell carcinoma of the oral cavity. Particularly, doctors should pay attention to the variety of symptoms characteristic of the initial period of the disease. Patients may complain of thickening of the tissues of the oral cavity, the presence of white spots, ulcerative lesions, which may be covered with plaque. Slight painful sensations are distinguished as manifestations of other diseases. Sometimes the symptoms are relieved by taking analgesics. Patients self-medicate and postpone visiting a specialized specialist for an indefinite time. This does not trouble both patients and some health workers. It should be noted that a typical symptom in the developed period is fetid odor from the mouth due to decay and infection of the tumor. Oral lesions are asymptomatic initially, highlighting the need for oral screening. Most dental professionals carefully examine the oral cavity and oropharynx during routine care and may do a brush biopsy of abnormal areas. The lesions may appear as areas of erythroplakia or leukoplakia and may be exophytic or ulcerated. Cancers are often indurated and firm with a rolled border. As the lesions increase in size, pain, dysarthria, and dysphagia may result. During the period of neglect, cancer of the oral cavity organs quickly spreads and destroys the surrounding tissues, infiltrates the floor of the oral cavity, palatine arches, pharynx, etc. To illustrate the problems outlined in the article, the authors took a clinical case that combines the problems of early diagnosis of oral cancers. It should be noted that in addition to the “inactivity” of the patient in solving problems that occurred in the oral cavity, the resolution of the situation was inhibited by the introduced quarantine measures.

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Das, S. N., N. N. Khanna, Sushila Khanna, and S. Gupta. "Cell surface antigens in squamous cell carcinoma of the oral cavity." Journal of Surgical Oncology 31, no. 3 (March 1986): 166–69. http://dx.doi.org/10.1002/jso.2930310305.

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Dundy, G., H. Kumar, A. Singh, and A. Chandarakant. "p53 immunohistochemical staining patterns in oral squamous cell carcinoma." Journal of Pathology of Nepal 6, no. 12 (September 24, 2016): 1013–17. http://dx.doi.org/10.3126/jpn.v6i12.16257.

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Background: Mutation of p53 gene is one of the most common events in oral carcinogenesis. Accumulation of p53 protein has also been detected in premalignant lesions.Materials and Methods: This study included 40 biopsy samples, which were received in department of pathology, Sarojini Naidu Medical College, Agra, to ascertain p53 expression by immunohistochemically, in patients with oral squamous cell carcinomas and to correlate its expression with histological grade, different sites in oral cavity and tobacco intake/smoking habits.Results: Out of 40 biopsies of oral mucosa, 03 showed normal oral mucosa and 37 were diagnosed as squamous cell carcinoma (SCC), most patients were in 5th and 6th decade and majority (86.5%) of oral SCC were males with buccal mucosa being the most common site. There was a statistically significant difference in p53 expression between oral SCC and normal oral mucosa (p value <0.05). Of total 37 cases, 12 cases were well differentiated type, 16 moderately differentiated and 09 of poorly differentiated type of SCC. In each category, about two thirds were positive for p53 staining. Out of total 37 cases of oral SCC, 64.9% were positive and 35.1% were negative for p53 expression, 34 cases had positive history of tobacco intake/smoking habits, of which 23 cases were positive while 11 cases were negative for p53 staining.Conclusion: Abnormal p53 protein was detected in 64.9% of oral squamous cell carcinoma, but not in normal oral mucosa. p53 expression was associated with malignant transformation of oral mucosa.

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Attila, Tan, Anna Fu, Nanda Gopinath, Catherine J. Streutker, and Norman E. Marcon. "Esophageal Papillomatosis Complicated by Squamous Cell Carcinoma." Canadian Journal of Gastroenterology 23, no. 6 (2009): 415–19. http://dx.doi.org/10.1155/2009/659820.

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Esophageal papillomatosis is a very rare condition that is believed to have a benign clinical course. Recent reports underscore the potential development of a malignancy in association with squamous papillomatosis of the esophagus. A case of esophageal papillomatosis complicated by the development of esophageal invasive squamous cell carcinoma diagnosed after esophagectomy, despite multiple nondiagnostic endoscopic biopsies, is described. The patient also developed squamous cell carcinoma in the oral cavity and pyloric channel. The finding of extensive esophageal papillomatosis and unremitting dysphagia symptoms should prompt investigations into an underlying associated malignancy.

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McHugh, Jonathan B. "Association of Cystic Neck Metastases and Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma." Archives of Pathology & Laboratory Medicine 133, no. 11 (November 1, 2009): 1798–803. http://dx.doi.org/10.5858/133.11.1798.

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Abstract Human papillomavirus is an established cause of oropharyngeal squamous cell carcinoma. Similar to cervical cancer, these cancers are usually caused by high-risk human papillomavirus types 16 and 18 and are associated with high-risk sexual behaviors. Human papillomavirus–associated oropharyngeal squamous cell carcinoma typically affects the palatine and lingual tonsils and frequently results in cystic neck metastases. The histopathology of this subset of head and neck squamous cell carcinoma is unique and typically characterized by poorly differentiated, nonkeratinizing morphology with a basaloid appearance. These tumors occur in younger patients and are more often seen in nonsmokers compared with conventional oral cavity and oropharyngeal squamous cell carcinomas. The incidence of human papillomavirus–associated squamous cell carcinoma is increasing. Recognition of this unique clinicopathologic subset of head and neck carcinoma is important because these patients typically respond more favorably to organ-sparing treatment modalities and have an improved prognosis.

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Chijiwa, H., K. Sakamoto, H. Umeno, T. Nakashima, G. Suzuki, and N. Hayafuchi. "Minor salivary gland carcinomas of oral cavity and oropharynx." Journal of Laryngology & Otology 123, S31 (May 2009): 52–57. http://dx.doi.org/10.1017/s002221510900509x.

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AbstractThis paper reviews 22 cases of minor salivary gland carcinoma of the oral cavity or oropharynx which were treated at Kurume University Hospital between 1976 and 2005. Minor salivary gland carcinoma was observed in eight of 362 patients with cancer of the oral cavity (2 per cent), and in 14 of 275 patients with cancer of the oropharynx (5 per cent). The five-year and 10-year survival rates of patients with oropharyngeal minor salivary gland carcinoma were 90 per cent. No statistically significant difference was observed between survival rates for oropharyngeal minor salivary gland carcinoma and for oropharyngeal squamous cell carcinoma (p = 0.06). The five- and 10-year survival rates of patients with oral cavity minor salivary gland carcinoma were 75 and 37 per cent, respectively. No statistically significant difference was observed between survival rates for oral cavity minor salivary gland carcinoma and oral cavity squamous cell carcinoma.Patients' survival results correlated well with the clinical stage of their lesions. A significant difference in survival was observed, comparing stage IV with stages I, II and III (p = 0.04). In contrast, no significant relationship was found between either survival and tumour type or survival and treatment. Adjuvant therapy is recommended for patients with grade III adenoid cystic carcinoma with perineural infiltration or intravascular infiltration.

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Martins, Allisson Filipe Lopes, Carlos Henrique Pereira, Marília Oliveira Morais, Paulo Otávio Carmo Souza, Lucas Borges Fleury Fernandes, Aline Carvalho Batista, and Elismauro Francisco Mendonça. "p53 and p16 expression in oral cavity squamous cell and basaloid squamous cell carcinoma." Oral Cancer 2, no. 1-2 (January 22, 2018): 7–17. http://dx.doi.org/10.1007/s41548-018-0004-1.

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Kutukova, S. I., N. P. Beliak, G. A. Raskin, M. S. Mukhina, Yu V. Ivaskova, and A. Ya Razumova. "PD-L1 and survival in oral cavity squamous cell carcinoma." Parodontologiya 25, no. 4 (December 19, 2020): 287–94. http://dx.doi.org/10.33925/1683-3759-2020-25-4-287-294.

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Relevance. Prognostic value of PD-L1 expression in oral cavity squamous cell carcinoma (OCSCC) and its effect on survival is still controversial. It should be to determine the prognostic role of PD-L1 expression on tumor and immune cells of OCSCC and assess their effect on overall survival (OS) and progression-free survival (PFS).Materials and methods. A prospective study included 145 patients, first diagnosed with OCSCC. PD-L1 expression on tumor and immune cells, infiltrating tumor and its microenvironment, was assessed in all tumor samples by IHC, CPS was calculated. Cut-off values were determined by ROC analysis for identification of PD-L1 expression effect on OS and PFS.Results. Most patients with oral mucosa squamous cell carcinoma showed positive expression of PD-L1 on tumor (77.2%) and immune cells (92.4%). The median PD-L1 expression on tumor cells was 13.5% [1.0-40.0], the median PD-L1 expression on immune cells was 5.0% [1.0-11.0], and the median CPS – 18.0 [3.0-7.8]. Univariate and multivariate analyses revealed a significant negative effect of PD-L1 expression on immune cells ≤ 7% on OS (HR 0.66; 95% CI 0.45-0.93; p = 0.0498); PD-L1 expression in tumor cells ≤ 15% (HR 0.65; 95% CI 0.43-0.98; p = 0.0416) and CPS ≤ 21 (HR 0.62; 95% CI 0.44-0.92; p = 0.0183) for PFS. PD-L1 expression in tumor cells ≤ 6% (HR 0.71; 95% CI 0.47-1.08; p = 0.1096) and CPS ≤ 7 (RR 0.67; 95% CI 0.44-1.01; p = 0.0575) had a confident tendency to negative impact on OS.Conclusion. Positive PD-L1 expression in tumor and immune cells as well as CPS are effective additional factors in the prognosis of the disease course, OS and PFS in patients with OCSCC.

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Wu, Chi-Sheng, Kai-Ping Chang, Chun-Nan OuYang, Huang-Kai Kao, Chuen Hsueh, Lih-Chyang Chen, Hsiao-Yun Cheng, et al. "ASC contributes to metastasis of oral cavity squamous cell carcinoma." Oncotarget 7, no. 31 (June 29, 2016): 50074–85. http://dx.doi.org/10.18632/oncotarget.10317.

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Ow, Thomas J., and Jeffrey N. Myers. "Current Management of Advanced Resectable Oral Cavity Squamous Cell Carcinoma." Clinical and Experimental Otorhinolaryngology 4, no. 1 (2011): 1. http://dx.doi.org/10.3342/ceo.2011.4.1.1.

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Chang, Steven S. "Quality Measures in Early Stage Oral Cavity Squamous Cell Carcinoma." Journal of Patient-Centered Research and Reviews 2, no. 2 (April 30, 2015): 84. http://dx.doi.org/10.17294/2330-0698.1069.

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