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Dissertations / Theses on the topic 'Squamous cell lung cancer'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 March 2023

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1

Lorch, Gwendolen. "Mechanisms of Receptor-Mediated Hypercalcemia in Human Lung Squamous Cell Carcinoma." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1242659291.

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2

Elakad, Omar [Verfasser]. "Functional and diagnostic relevance of FGFR1-dependent signaling pathways in squamous cell lung cancer / Omar Elakad." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1218299207/34.

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3

Ghosh, Monimoy. "The role of apoptosis and expression of bc12 and CD40 in squamous cell carcinoma of the lung." Thesis, University of Warwick, 1997. http://wrap.warwick.ac.uk/73486/.

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In spite of extensive research there is little information about apoptosis or programmed cell death in the genesis and progression of cancers of the lung. In our project we have investigated the role of apoptosis and two of the genes controlling apoptosis (bcl2 and C040) in squamous cell carcinoma of the lung. Also we have tried to formulate an accurate way of measuring apoptotic rate in tumour specimens. We counted apoptotic cells in Haematoxylin and Eosin stained histological sections of squamous cell carcinoma of the lung. The apoptotic indices we obtained were very reliable showing remarka

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4

Mancuso, Giuseppe. "Prognostic Impact of a 3-MicroRNA Signature on Cytological Samples of Small-Cell Lung Cancer and on Surgical Samples of Squamous Cell Carcinoma of the Lung." Doctoral thesis, Università del Piemonte Orientale, 2017. http://hdl.handle.net/11579/102510.

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Lung cancer is currently the most common malignancy and the leading cause of cancerrelated death worldwide. There are two main types: small cell lung cancer (SCLC) and nonsmall lung cancer (NSCLC). As revealed by recent genome-wide studies, individual lung tumors also possess highly diverse genomes, which further underscore the biological complexity of these diseases. Untangling the relationship between lung tumor histotype, phenotype and molecular heterogeneity represents a critical barrier in improving the clinical outcome of thoracic malignancies, which collectively account for most cancer-

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5

Malchers, Florian [Verfasser], and Manolis [Akademischer Betreuer] Pasparakis. "FGFR1-Dependency Prediction by Genomic and Functional Analysis in Squamous Cell Lung Cancer / Florian Malchers. Gutachter: Manolis Pasparakis." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/1061121267/34.

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6

Yoshioka, Hiroshige. "Efficacy and safety analysis according to histology for S-1 in combination with carboplatin as first-line chemotherapy in patients with advanced non-small-cell lung cancer: updated results of the West Japan Oncology Group LETS study." Kyoto University, 2014. http://hdl.handle.net/2433/185192.

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7

Cummings, Natalie Marie. "The role of epithelial mesenchymal transition in the progression of bronchial dysplasia." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607647.

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8

MARCAZZAN, SABRINA. "DEVELOPMENT OF MOUSE MODELS OF ORAL SQUAMOUS CELL CARCINOMA (OSCC) METASTASIS FOR THE EVALUATION OF EMERGING ANTI-METASTATIC NANOMEDICINE DRUGS." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/603863.

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Oral Squamous Cell Carcinoma (OSCC) is included in the Head and Neck Squamous Cell Carcinoma (HNSCC) group, which is the sixth most common cancer diagnosed worldwide. While the locoregional control has been increased thanks to the combination therapy, the incidence of distant metastasis is increasing. Nanomedicine therapies have been clinically approved for the treatment of several types of cancers and were used in few clinical trials on HNSCC patients. However, the efficacy of nanomedicine therapies was limited, especially for the treatment of metastatic OSCC. In the preclinical setting, more

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9

Zuyderduyn, Scott Dorjan. "Advancing the serial analysis of gene expression technique and its application to the study of the development of squamous cell lung cancer." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/7725.

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Lung cancer is one of the most common and deadliest forms of cancer. Squamous cell lung carcinomas (SCC), a common lung cancer subtype, feature a series of identifiable premalignant and early malignant forms that progress sequentially into full-blown tumours. This thesis describes a sophisticated and statistically rigorous analysis of global gene expression profiles taken from samples of several key stages of progression. This dataset was generated using serial analysis of gene expression (SAGE), a powerful transcriptome profiling technique that captures small sequence tags from each transcrip

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10

Masago, Katsuhiro. "Clinical significance of pretreatment serum amphiregulin and transforming growth factor-alpha, and an epidermal growth factor receptor somatic mutation in patients with advanced non-squamous, non-small cell lung cancer." Kyoto University, 2009. http://hdl.handle.net/2433/124291.

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11

Abou, faycal Chérine. "Le sVEGFR1 : quel rôle dans la réponse aux thérapies antiangiogéniques dans les carcinomes pulmonaires squameux ?" Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV022/document.

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Le VEGF-A joue un rôle clé au cours de l’angiogenèse physiologique mais aussi de la néo-vascularisation tumorale essentielle à la croissance des tumeurs malignes. Le VEGF-A et ses récepteurs (VEGFR1/2) représentent une cible de première importance pour le développement de thérapies anti-tumorales, et un certain nombre de médicaments anti-angiogéniques (AAG) inhibant le VEGF-A ou ses récepteurs sont actuellement utilisés en clinique dans le traitement des carcinomes pulmonaires. Parmi les thérapies anti-angiogéniques ciblant le VEGF-A, on peut lister soit l’anticorps monoclonal anti-VEGF Bevaci

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12

Mascaux, Céline. "Etude de la genèse du carcinome épidermoïde bronchique: évolution de l'expression des protéines, des ARNs messagers et des microARNs à tous les stades du processus de cancérisation." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210516.

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Introduction<p><p>Avec plus de 7000 cas diagnostiqués par an en Belgique, le cancer bronchique est l’un des cancers les plus fréquents chez l'homme. Son pronostic est très réservé, la survie à 5 ans tous stades confondus étant inférieure à 15 %. Ce faible taux de guérison s’explique en grande partie par le fait que le diagnostic se réalise généralement à un stade avancé de la maladie. Une méthode de détection précoce, l’endoscopie en autofluorescence, exploite des variations de la fluorescence bronchique sous l'effet d'un laser et permet ainsi de dévoiler des lésions précancéreuses invisibles

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13

Sarvi, Sana. "Small cell lung cancer and cancer stem cell-like cells." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9542.

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Small cell lung cancer (SCLC) is a highly aggressive malignancy with extreme mortality and morbidity. Although initially chemo- and radio-sensitive, almost inevitable recurrence and resistance occurs. SCLC patients often present with metastases, making surgery not feasible. Current therapies, rationally designed on underlying pathogenesis, produce in vitro results, however, these have failed to translate into satisfactory clinical outcomes. Recently, research into cancer stem cells (CSCs) has gained momentum and form an attractive target for novel therapies. Based on this concept, CSCs are the

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14

Hui, King-cheung, and 許景祥. "Biomarkers for esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B41634020.

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15

Sun, Li, and 孫莉. "Molecular cytogenetics of oral squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B36544267.

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16

Yu, Zhuoyou, and 余卓由. "Role of DNAJB6 in esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196454.

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Esophageal cancer (EC), which is geographically diverse, has only a 10.7% five-year survival rate. One of the histologic forms, esophageal squamous cell carcinoma (ESCC), in Hong Kong accounts for 81.5% of the total EC cases and its five-year survival rate is only ~14%, due to its high frequency of metastasis. In our previous studies, functional complementation study of chromosome 9 defects led to the discovery of a novel tumor suppressor gene, Deleted in Esophageal Cancer 1 (DEC1), mapping to 9q32. DEC1 was shown to reduce tumorigenicity in a mouse model and its expression was shown to be as

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17

Emich, Helena. "Clinical implications of cancer stem cell properties in oral squamous cell carcinoma." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8479.

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CD44 has been described as a marker of cancer stem cells in oral squamous cell carcinoma (OSCC). The main objective of this study was to characterise expression of CD44 in both fresh samples of human OSCC and in cell lines generated from them, and to examine its correlation with selected clinicopathological parameters of the tumours of origin. The epithelial fraction in 20 fresh OSCC samples was identified by the standard method using the negative selection technique with antibodies against non-tumour cells. A novel method of identifying the epithelial fraction, termed positive selection, was

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18

Oosterhout, Anselmus Gerardus Maria van. "Small cell lung cancer and brain metastasis." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=6643.

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19

Seute, Tatjana. "Neurologic complications in small cell lung cancer." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=9520.

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20

Macaulay, Valentine. "Growth regulation in small cell lung cancer." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47547.

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21

Chung, Man-fai Yvonne, and 鍾文暉. "Investigation of biomarkers in esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43704025.

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22

Frede, Julia. "Cellular dynamics in Oesophageal Squamous Carcinogenesis." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708817.

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23

Lee, Richard. "An improved system for lung cancer diagnosis using lung cell images." Diss., Online access via UMI:, 2006.

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24

Hu, Yingchuan, and 胡穎川. "Molecular pathogenesis of oesophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31241797.

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25

Law, Bic-fai Fian, and 羅璧輝. "Molecular genetics of esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B3660446X.

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26

Escriu, Carlos. "The role of Mst2 in oral squamous cell cancer progression." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708173.

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27

Chan, Pui-man Poemen. "Micrometastases of esophageal cancer /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36404652.

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28

Fu, Li. "Identification and characterization of cancer-related genes in esophageal squamous cell carcinoma." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557820.

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29

LE, HOANG BA PATRICK. "Interet diagnostic du squamous cell carcinoma en pathologie pleuropulmonaire." Nice, 1988. http://www.theses.fr/1988NICE6550.

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30

Fu, Li, and 付利. "Identification and characterization of cancer-related genes in esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557820.

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31

Wong, Wing-sze, and 黃詠詩. "Fusion genes in non-small cell lung cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43781378.

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32

Sikkink, Stephen K. "Genetic pathology of non-small cell lung cancer." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250405.

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33

Ng, Sheng Rong. "CRISPR-mediated interrogation of small cell lung cancer." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117782.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged student-submitted from PDF version of thesis. Vita.<br>Includes bibliographical references.<br>Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine lung carcinoma that remains among the most lethal of solid tumor malignancies. Despite decades of research, treatment outcomes for SCLC remain very poor, highlighting the need for novel appr

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34

Lawson, Malcolm Hedley. "Determinants of chemoresistance in small cell lung cancer." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609102.

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35

Hodkinson, Philip Simon. "Tumour microenvironment interactions of small cell lung cancer." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4254.

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Small cell lung cancer (SCLC) is characterised by rapid growth, early metastatic spread and poor long-term survival. The tumour is initially sensitive to chemotherapy and thus objective response rates are high. Unfortunately, this response is often short-lived and SCLC recurs with acquired drug resistance, resulting in early patient death. Despite intensive chemo- and radiotherapy regimes survival has not improved significantly in 20 years. Prior research suggests a critical role for the tumour microenvironment in the pathogenesis of other cancers. Therefore, investigating interactions between

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36

Swinson, Daniel. "Hypoxic markers in non-small cell lung cancer." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29476.

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Hypoxia is an important factor in the pathogenesis of solid tumours. Hypoxia inducible factors (HIF)-1alpha and HIF-2alpha are transcription factors that in part mediate the cellular response to hypoxia. These transcription factors are involved in the regulation of angiogenesis, anaerobic metabolism, pH homeostasis, erythropoiesis and cell death.;Immunohistochemical (IHC) assays were optimised for HIF-1alpha and one of its transcriptional targets, Carbonic Anhydrase (CA) IX. Attempts to optimise an IHC assay for HIF-2alpha failed to produce reproducible staining. A scoring system was also devi

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37

Moka, Nagaishwarya, Manisha Nukavarapu, Jennifer Phemister, and Mckinney Jason. "Small cell lung cancer(SCLC) disguised as Dysphagia." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/168.

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Common presenting symptoms of Lung cancer are cough, hemoptysis, chest pain, dyspnea, pleurisy. Dysphagia is a very uncommon presenting feature of Lung cancer. Incidence of Dysphagia in Lung cancer is unclear from Literature. Causes of Dysphagia in case of Lung cancer are Anatomically classified as Oropharyngeal and Esophageal. Causes of oropharyngeal dysphagia are oral candidiasis, oropharyngeal Metastasis of Lung cancer. Causes of esophageal dysphagia are Cervical or Mediastinal Lymphadenopathy, Motor dysfunction because of Brain stem Metastasis, Lambert eaton syndrome, Esophageal candidiasi

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38

Wong, Wing-sze. "Fusion genes in non-small cell lung cancer." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43781378.

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39

Cooke, Lynn Denise. "DNA content and cell kinetics in squamous cell carcinoma of the head and neck region." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359220.

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40

Qadir, Fatima. "Cellular and molecular signature of oral squamous cell carcinoma." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/39763.

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Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. It is a result of numerous aetiological factors such as genetic predisposition, smoking, excessive alcohol consumption and viruses such as the human papilloma virus. Due to late diagnosis it has a high mortality and morbidity rates which has remained unchanged over the last 5 decades. Currently no screening is available for high risk patients for better monitoring. Diagnosing OSCC relies on histopathology of biopsy tissue, reviewed for dysplasia and advancing lesions. Although the technique has been used for decades

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41

Sáenz, Sardà Xavier. "Progression pathways of squamous cell carcinoma associated with actinic damage: From cancer field to actinic keratosis and invasive squamous cell carcinoma." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667918.

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Se pensaba que la progresión de una queratosis actínica (AK) a carcinoma escamoso infiltrante (SCC) de piel ocurría siempre y cuando la neoplasia intra-epidérmica ocupara todo el espesor de la epidermis como ocurre en la vía clásica (CP) descrita en el cáncer de cérvix. Sin embargo, el carcinoma escamoso infiltrante cutáneo puede aparecer directamente desde una displasia que sólo ocupe el tercio inferior de la epidermis (AK I, vía diferenciada o DP). Esta segunda vía de progresión se ha descrito en el SCC de vulva y de cavidad oral , cuyo comportamiento biológico es además más agresivo. Est

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42

Zhu, Cailei, and 祝彩磊. "Identification and characterization of CHL1 in esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B46329559.

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43

Wang, Wei. "Modulation of immune cell responses by small cell lung cancer cells." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/modulation-of-immune-cell-responses-by-small-cell-lung-cancer-cells(7bdc85c2-acd8-4f13-9d2b-e2ce07d1567b).html.

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Small Cell Lung Cancer (SCLC) accounts for 15-20% of all lung cancers and kills at least one person every 2 hours in the UK. There is no effective treatment and overall 2-year survival is less than 5%. Patients with SCLC have poorly understood local and systemic immune defects. Previous studies have shown several important defects in cell-mediated immune responses in patients with SCLC. A better understanding of interactions between SCLC tumour cells and immune cells may lead to the development of novel therapeutic approaches. There is increasing recognition that immunological biomarkers may a

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44

Bingula, Rea. "Non-small cell lung cancer, immunity and microbiota : laying ground for the gut-lung-lung cancer axis in human subjects." Thesis, Université Clermont Auvergne‎ (2017-2020), 2019. http://www.theses.fr/2019CLFAS009.

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Le cancer du poumon est la principale cause de décès par cancer dans le monde. En dépit de la variété de traitements disponibles, tels que la chirurgie, la chimiothérapie, la radiothérapie et l’immunothérapie, la survie moyenne à 5 ans est de 60 %. L’une des raisons sous-jacente est une très grande variabilité de réponse au traitement, expliquée par les antécédents génétiques du patient et depuis peu par son microbiote. Le terme « microbiote » regroupe les bactéries, les archées, les champignons, les virus et les protistes qui colonisent notre organisme. Des études utilisant des modèles animau

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45

Liu, Xiaobing, and 劉小兵. "Dysregulation of microRNAs in tongue squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40203499.

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46

Kwong, Fung Mei. "Investigation of a known tumor suppressor gene, p161NK4a, in human esophageal squamous cell carcinoma cell lines /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20KWONG.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 74-87). Also available in electronic version. Access restricted to campus users.

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47

鄧焯安 and Cheuk-on Tang. "Cytogenetic and molecular study of oesophageal squamous cellcarcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31242327.

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48

Tam, Hok-nang Alex. "Epigenetic inactivation of protocadherin PCDH10 in esophageal cancer /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36586390.

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49

Chan, Kit-ying Loucia. "Expression analysis of Candidate cancer genes in non-small cell lung cancer /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38480360.

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50

祝彩磊 and Cailei Zhu. "Characterization of tumor suppressing function of PCAF in esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557480.

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