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Journal articles on the topic 'Squamous intraepithelial neoplasias'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Tóth, Gábor, Gábor László Sándor, Andrea Gyenes, et al. "Szemfelszíni laphám-neoplasia." Orvosi Hetilap 158, no. 51 (2017): 2011–22. http://dx.doi.org/10.1556/650.2017.30939.

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Abstract: To summarize actual knowledge on epidemiology, etiology, pathology, clinical apparence and treatment of ocular surface squamous neoplasias. We summarize up-to-date literature on conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma and present some own cases. Ocular surface squamous neoplasia is the most common malignant ocular surface tumor and the third most common ocular malignancy following malignant melanoma and lymphoma. In spite of its low malignant potential, in advanced stages it may reduce visual acuity significantly or even the eye globe has to be rem

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2

Lyons, Keegan, and Samantha Butler. "Anal Intraepithelial Neoplasia from a Pathologists Point of View." Clinics in Colon and Rectal Surgery 31, no. 06 (2018): 328–35. http://dx.doi.org/10.1055/s-0038-1668102.

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AbstractAnal squamous cell carcinoma is a relatively rare diagnosis, but its incidence has continued to rise. Anal squamous cell carcinoma and its precursor lesion, anal intraepithelial neoplasia (AIN), are human papillomavirus (HPV)-associated squamous neoplasias. High-risk HPV subtypes cause cellular proliferation in the anal transformation zone mucosa leading to similar dysplastic changes as seen in the cervix. Unified cytologic and histologic classification systems have emerged for all HPV-associated squamous lesions of the lower anogenital tract due to recent advancements in the understan

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Cheng, Yong, Hong-yan Zhang, Ying Zhou, Feng Tao, and Yong-hua Yu. "Decreased expression of GRIM-19 and its association with high-risk HPV infection in cervical squamous intraepithelial neoplasias and cancer." Clinical & Investigative Medicine 37, no. 2 (2014): 77. http://dx.doi.org/10.25011/cim.v37i2.21089.

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Purpose: GRIM-19 has been shown to be down-regulated in cervical cancers. This study investigated the expression of GRIM-19 in cervical intra-epithelial neoplasias and its association with high-risk human papillomavirus (HR-HPV) infection. Methods: The expression of GRIM-19 was assessed in cervical exfoliated cells and cervical intra-epithelial neoplasia tissues by immunohistochemistry, and the level of GRIM-19 was also evaluated by Western blotting using cervical exfoliated cells. HR-HPV infection of cervical exfoliated cells was detected by HC II. Results: GRIM-19 is predominantly expressed

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Zarochentseva, N. V., V. I. Krasnopolskiy, О. А. Misyukevich, I. V. Barinova, М. V. Mgeliashvili, and О. V. Rovinskaya. "Rare forms of vaginal diseases in women after panhysterectomy." Voprosy ginekologii, akušerstva i perinatologii 19, no. 5 (2020): 150–55. http://dx.doi.org/10.20953/1726-1678-2020-5-150-155.

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The article presents clinical observations of the development of precancerous conditions of the vaginal vault, and also squamous cell cancer in women after panhysterectomy. The examination included: comprehensive vaginoscopy, cytological examination of vaginal wall smears, human papillomavirus test, histological examination of bioplates. Conclusion. Panhysterectomy does not guarantee the absence of precancerous lesions of the vagina or vaginal cancer. Therefore, routine screening (cytology, testing for high-risk human papillomavirus, vaginoscopy) should be continued in women after panhysterect

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Gebauer, G., J. Schleibaum, S. Aulmann, P. Schirmacher, C. Sohn, and P. Sinn. "Low-level amplifications of the human telomerase gene (TERC) regularly is associated with vulvar intraepithelial neoplasia." Journal of Clinical Oncology 24, no. 18_suppl (2006): 20060. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.20060.

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20060 Background: Invasive squamous carcinomas of the vulva frequently harbor gains on the long arm of chromosome 3, including the human telomerase gene locus (TERC). Vulvar cancer develops from precursor lesions known as vulvar intraepithelial neoplasia (VIN) which frequently occur simultaneously in multiple locations and have a considerable risk or recurrence during follow-up. We investigated TERC gene copy number in a series of vulvar intraepithelial neoplasias to determine the risk of progression in these lesions. Methods: A total of 20 cases of high grade vulvar intraepithelial neoplasias

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Ershov, V. A., A. S. Lisyanskaya, and G. M. Manikhas. "Expression of human papillomavirus L1 protein and NuMA1 at cervical intraepithelial neoplasia." Scientific Notes of the Pavlov University 26, no. 2 (2019): 18–27. http://dx.doi.org/10.24884/1607-4181-2019-26-2-18-27.

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Relevance. Cervical cancer – one of malignant new growths most often met among women. Intraepithelial changes precede to it; these changes can disappear spontaneously or progress to cancer. For the present moment, there are no markers describing the outcome of cervical intraepithelial neoplasia.The objective was to research the expression L1 HPV and NuMA1 as factors of prognosis HPV-positive cervical intraepithelial neoplasias by high-risk human papillomavirus.Material and methods. The biopsies of 178 women from HPV-positive cervical neoplasias were studied by cytological, histological, immuno

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Maksadovna, Yunusova Zarnigor. "MODERN VIEWS OF THE PROGRESSION OF CERVICAL NEOPLASIA AFTER DESTRUCTIVE TREATMENTS FOR CERVICAL DISEASES." International Journal of Medical Sciences And Clinical Research 4, no. 5 (2024): 42–48. http://dx.doi.org/10.37547/ijmscr/volume04issue05-08.

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Diagnosis of cervical intraepithelial neoplasia in women with a history of exocervix ablation is difficult due to the displacement of the junction of the squamous and prismatic epithelium into the cervical canal. Diagnostic significance in these cases belongs to the data of cytological examination of cells obtained with the help of a cyto-brush from the cervical canal. The diagnosis was clarified by coni biopsy. In 20 (17%) of the 70 women followed, CIN and cervical cancer were detected. Patients with ablation exocervixes have a history of developing intracervical neoplasias with the persisten

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Fachetti-Machado, Giselle, Rosane Figueiredo-Alves, and Marise Moreira. "Performance of Conventional Cytology and Colposcopy for the Diagnosis of Cervical Squamous and Glandular Neoplasias." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 40, no. 07 (2018): 410–16. http://dx.doi.org/10.1055/s-0038-1666995.

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Objective To estimate the cytological and colposcopic performances for the diagnosis of cervical neoplasias. Methods Cross-sectional retrospective study with data from patients' charts. The participants underwent colposcopy, guided biopsies, and excision when needed. The cytological and colposcopic categorization followed the Bethesda System and the international colposcopic terminologies. The cytology and colposcopy performances were evaluated by sensitivity (SE), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV) analyses with 95% confidence interval (95%

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Fachetti-Machado, Giselle, Rosane Ribeiro Figueiredo-Alves, and Marise Amaral Rebouças Moreira. "Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias." Archives of Gynecology and Obstetrics 305, no. 5 (2021): 1319–27. http://dx.doi.org/10.1007/s00404-021-06284-4.

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Abstract Purpose To evaluate prevalence and diagnostic performance of three colposcopic images to diagnose squamous and glandular cervical precursor neoplasias. Methods Cross-sectional study, conducted through analysis of stored digital colposcopic images. To evaluate the diagnostic performance of three images, herein named grouped glands, aceto-white villi, and atypical vessels, for detection of adenocarcinoma in situ (AIS) and cervical squamous intraepithelial neoplasias (CIN) grades 2 and 3, calculations of sensitivity, specificity, accuracy, positive likelihood ratio, receiver operating ch

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Rubio, C. A., Fu-sheng Liu, and Heng-Zong Zhao. "Histological Classification of Intraepithelial Neoplasias and Microinvasive Squamous Carcinoma of the Esophagus." American Journal of Surgical Pathology 13, no. 8 (1989): 685–90. http://dx.doi.org/10.1097/00000478-198908000-00007.

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Lee, Sun-Joo, Woo Young Kim, Jeong-Won Lee, et al. "Conization Using Electrosurgical Conization and Cold Coagulation for International Federation of Gynecology and Obstetrics Stage IA1 Squamous Cell Carcinomas of the Uterine Cervix." International Journal of Gynecologic Cancer 19, no. 3 (2009): 407–11. http://dx.doi.org/10.1111/igc.0b013e3181a1a297.

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Objective:This study was performed to evaluate the efficacy and feasibility of electrosurgical conization and cold coagulation as definitive treatments for patients with International Federation of Gynecology and Obstetrics stage IA1 squamous cell carcinoma of the cervix and a resection margin free from (micro)invasive carcinoma after conization.Methods:Patients with stage IA1 cervical squamous cell carcinoma without lymphovascular space invasion who had been treated by electrosurgical conization and cold coagulation and who wanted to preserve fertility (or only undertake conservative treatmen

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Noël, Jean-Christophe, and Philippe Simon. "Limitations on the Detection Rate of High-Risk HPV by Hybrid Capture 2 Methodology in High Grade Intraepithelial (HSIL) or Atypical Squamous Cells-Cannot Exclude HSIL (ASC-H) Cytological Lesions with Proved CIN2+." Analytical Cellular Pathology 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/746502.

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Recent literature data suggest that the high-risk human papillomaviruses (HR-HPVs) testing with several molecular techniques could be an alternative to cytology in the detection of cervical intraepithelial neoplasias of grade 2 or worse (CIN2+). However, any molecular techniques have its own limits and may give false negative results which must be clearly known before undertaking a primary HPV screening. This study aims to evaluate the performance of the high-risk HPV hybrid capture II detection kit (HCII) which is considered as a “gold standard technique” in a series of 100 women having prove

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Manderwad, Guru Prasad, Chitra Kannabiran, Santosh G. Honavar, and Geeta K. Vemuganti. "Lack of Association of High-Risk Human Papillomavirus in Ocular Surface Squamous Neoplasia in India." Archives of Pathology & Laboratory Medicine 133, no. 8 (2009): 1246–50. http://dx.doi.org/10.5858/133.8.1246.

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AbstractContext.—Ocular surface squamous neoplasia (OSSN) represents a spectrum of ocular surface tumors ranging from intraepithelial to invasive. The genesis of OSSN is multifactorial, possibly including human papillomavirus (HPV) infection, the role of which is controversial.Objective.—To evaluate the role of high-risk HPV16 and HPV18 in OSSN.Design.—Retrospective and prospective noncomparative case series. In this study, histologically proven cases of OSSN were evaluated in formalin-fixed, paraffin-embedded sections (n = 50) and fresh tissues (n = 7) for the presence of HPV by polymerase ch

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Kim, W. Y., J. W. Lee, J. J. Choi, et al. "Increased expression of Toll-like receptor 5 during progression of cervical neoplasia." International Journal of Gynecologic Cancer 18, no. 2 (2008): 300–305. http://dx.doi.org/10.1111/j.1525-1438.2007.01008.x.

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The purpose of this study was to determine whether Toll-like receptor 5 (TLR5) expression was associated with disease progression in cervical neoplasia. TLR5 expression was evaluated by immunohistochemistry (IHC) in 55 formalin-fixed paraffin-embedded cervical tissues; 10 normal cervical specimens, 9 low-grade cervical intraepithelial neoplasias (CINs), 12 high-grade CINs, and 24 invasive squamous cell carcinomas (ISCCs). TLR5 expression was also evaluated at the RNA level, in fresh, frozen cervical carcinoma tissues by real-time quantitative RT-PCR. TLR5 expression, which was mainly observed

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Karmakova, T. A., R. I. Yakubovskaya, O. I. Trushina, et al. "IMMUNOCYTOCHEMICAL STUDY OF MUC1 MUCIN IN THE CERVICAL EPITHELIUM." Russian Journal of Oncology 17, no. 2 (2012): 23–28. http://dx.doi.org/10.17816/onco39931.

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Immunocytochemical (ICC) staining using the monoclonal antibody ICO25 was performed to examine MUC1 mucin expression in the cervical smears obtained from healthy women (34), patients having benign cervical disease (n = 22), low-grade cervical intraepithelial neoplasia (CIN1, n = 3), high-grade CIN (CIN2-3, n = 32), early squamous cervical cancer (SCC, n = 12), and from those after organ-saving treatment (n = 66). In CIN2-3 and SCC, atypical squamous epithelial cells were shown to be detectable by ICO24 ICC staining in the vast majority (95%) of cases. Negative staining of dyskaryotic naked nuc

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Tsou, Yung-Kuan, Chi-Ju Yeh, Puo-Hsien Le, Bo-Huan Chen, and Cheng-Hui Lin. "Endoscopic Resection of Residual or Recurrent Lesions after Circumferential Radiofrequency Ablation for Flat Superficial Esophageal Squamous Cell Neoplasias." Cancers 15, no. 14 (2023): 3558. http://dx.doi.org/10.3390/cancers15143558.

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The optimal treatment of residual/recurrent superficial esophageal squamous cell neoplasias (SESCNs) after circumferential radiofrequency (RFA) remains unclear. We aimed to report the efficacy and safety of endoscopic resection (ER) of residual/recurrent SESCNs after RFA. Patients who underwent circumferential RFA with residual/recurrent SESCNs and were treated with ER were retrospectively collected. SESCN patients treated with primary endoscopic submucosal dissection (ESD) served as the control group. Eleven patients who underwent RFA had a total of 17 residual (n = 8) or recurrent (n = 9) SE

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Yao, Jun, Jun Li, Peng Wang, Feng Liu, and Zhaoshen Li. "A novel technique using high energy synchronous double-wave laser in endoscopic submucosal dissection of patients with superficial esophageal neoplasm." Endoscopy 50, no. 12 (2018): 1175–79. http://dx.doi.org/10.1055/a-0620-8403.

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Abstract Background Endoscopic submucosal dissection (ESD) has been widely used to treat superficial esophageal neoplasms (SENs). Intraoperative bleeding is one of the main concerns that makes ESD in the esophagus more difficult and time consuming with higher complication rates. We introduced a novel laser endoknife system that enabled better intraoperative hemostasis, and preliminarily investigated its feasibility in ESD for patients with SENs. Methods 17 consecutive patients with SENs were prospectively enrolled. The laser endoknife system was used in marking and submucosal dissection. Data

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Gross, G., and H. Pfister. "Role of human papillomavirus in penile cancer, penile intraepithelial squamous cell neoplasias and in genital warts." Medical Microbiology and Immunology 193, no. 1 (2004): 35–44. http://dx.doi.org/10.1007/s00430-003-0181-2.

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Liang, Shuang, Tian Tian, Xubin Liu, et al. "Microarray analysis revealed markedly differential miRNA expression profiles in cervical intraepithelial neoplasias and invasive squamous cell carcinoma." Future Oncology 10, no. 13 (2014): 2023–32. http://dx.doi.org/10.2217/fon.14.38.

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Michal, Michal, Ondřej Hes, Denisa Kacerovská, et al. "Classification of the penile intraepithelial neoplasias preceding invasive squamous cell carcinomas and their analogy with precancerous lesions of vulvar squamous cell carcinoma." Czech Urology 18, no. 2 (2014): 94–100. https://doi.org/10.48095/cccu2014021.

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Karakhalis, L. Yu, V. S. Petrenko, and S. I. Petrenko. "Study of the role of various diagnostic methods in patients with benign and neoplastic cervical diseases." Meditsinskiy sovet = Medical Council, no. 15 (October 21, 2023): 45–51. http://dx.doi.org/10.21518/ms2023-335.

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Introduction. Cervical intraepithelial neoplasias that have been recognized as a precursor of squamous cell carcinoma are subject to active detection for the purpose of eradication. Human papillomavirus (HPV) exposure of women is the major risk factor for carcinogenesis, which is a necessary part for the formation of a pre-tumour and malignant phenotype. Cervical intraepithelial neoplasias that precede the development of squamous cell carcinoma should be actively detected and treated early. The identification of patients with HPV is an important part of subsequent therapies. Inosine pranobex i

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Conde-Ferráez, Laura, Alberto Chan-Mezeta, Jesús Gilberto Gómez-Carballo, Guadalupe Ayora-Talavera, and María del Refugio González-Losa. "Human Papillomavirus Genotypes Infecting the Anal Canal and Cervix in HIV+ Men and Women, Anal Cytology, and Risk Factors for Anal Infection." Pathogens 12, no. 2 (2023): 252. http://dx.doi.org/10.3390/pathogens12020252.

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The incidence of anal intraepithelial neoplasias associated with HPV is rising worldwide. In the general population, this pathology is rare, but individuals living with HIV/AIDS are at a significantly higher risk. We aimed to study HPV infection and performed cytological screening to study the epidemiological and behavioral determinants in a group of men and women living with HIV from a region in Mexico with high HIV incidence. This was a cross-sectional study including adults living with HIV/AIDS performed in Merida (Mexico). We invited patients of public HIV/STD clinics and those affiliated

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Chinn, Zachary, Mark H. Stoler, and Anne M. Mills. "PD-L1 and IDO expression in cervical and vulvar invasive and intraepithelial squamous neoplasias: implications for combination immunotherapy." Histopathology 74, no. 2 (2018): 256–68. http://dx.doi.org/10.1111/his.13723.

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Monsonego, J., L. Zerat, F. Catalan, and Y. Coscas. "Genital Human Papillomavirus Infections: Correlation of Cytological, Colposcopic and Histological Features with Viral Types in Women and Their Male Partners." International Journal of STD & AIDS 4, no. 1 (1993): 13–20. http://dx.doi.org/10.1177/095646249300400104.

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To determine the incidence of anogenital papillomavirus infections and to assess the value of available diagnostic methods, we compared the cytological, colposcopic and histological features of anogenital papillomavirus-related lesions with their associated human papillomavirus types (HPV) in 300 women and in their male partners. HPV-type deoxyribonucleic acid was detected by blot hybridization in 398 out of 624 subclinical and clinically defined anogenital lesions. Whatever the site of the lesion, condylomas and low-grade intraepithelial neoplasia (IEN) were found in 84% of lesions associated

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Tsimplaki, Elpida, Elena Argyri, Lina Michala, et al. "Human Papillomavirus Genotyping and E6/E7 mRNA Expression in Greek Women with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva." Journal of Oncology 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/893275.

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A large proportion of vaginal and vulvar squamous cell carcinomas (SCCs) and intraepithelial neoplasias (VAIN and VIN) are associated with HPV infection, mainly type 16. The purpose of this study was to identify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33, and 45) in 56 histology samples of VAIN, VIN, vaginal, and vulvar SCCs. HPV was identified in 56% of VAIN and 50% of vaginal SCCs, 71.4% of VIN and 50% of vulvar SCCs. E6/E7 mRNA expression was found in one-third of VAIN and in all vaginal SCCs, 42.9% of VIN and 83.3% of vulvar SCCs. Our data indicated t

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Sadalla, José Carlos, Sílvia Vanessa Lourenço, Mirian Nacagami Sotto, Edmund Chada Baracat, and Jesus Paula Carvalho. "Claudin and p53 expression in vulvar lichen sclerosus and squamous-cell carcinoma." Journal of Clinical Pathology 64, no. 10 (2011): 853–57. http://dx.doi.org/10.1136/jclinpath-2011-200103.

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AimsVulvar squamous-cell carcinoma (SCC) is a rare gynaecological cancer. Vulvar SCC has been shown to develop from vulvar intraepithelial neoplasias, which are related to lichen sclerosus (LS). Most studies to date have compared vulvar SCC with LS only morphologically, but no detailed molecular analysis has been performed. The objective was to compare claudin and p53 expression in these diseases and determine if there was any association with expression and vulvar SCC progression.MethodsImmunohistochemical analysis was performed in order to determine expression of p53 and claudin 1, 2, 3, 4,

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Prisyazhnaya, T. S., V. A. Mikhaylyukova, I. V. Berlev, and A. V. Malek. "Risk factors modulating the course of low-grade squamous intraepithelial lesions in women of reproductive age." Tumors of female reproductive system 17, no. 1 (2021): 45–52. http://dx.doi.org/10.17650/1994-4098-2021-17-1-45-52.

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Background. Infection with oncogenic types of human papillomavirus (HPV) is the leading cause of cervical cancer and its immediate precursors – squamous intraepithelial lesions. However, the persistence of HPV may not be sufficient for the occurrence of malignant transformation, and there may be other exogenous or endogenous factors that, in combination with the virus, increase the risk of developing and progressing cervical neoplasia.Objective: identification of risk factors that modulate the course of low-grade squamous intraepithelial lesions (LSIL) in women of reproductive age.Materials an

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Gaiotto, Maria Angélica M., José Focchi, Julisa L. C. Ribalta, et al. "Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma." American Journal of Obstetrics and Gynecology 190, no. 5 (2004): 1278–82. http://dx.doi.org/10.1016/j.ajog.2003.12.017.

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Zhou, Jian-hong, Feng Ye, Huai-zeng Chen, Cai-yun Zhou, Wei-guo Lu, and Xing Xie. "Altered expression of cellular membrane molecules of HLA-DR, HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma." Life Sciences 78, no. 22 (2006): 2643–49. http://dx.doi.org/10.1016/j.lfs.2005.10.039.

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Pliten, O. N. "Степень экспрессии белка пролиферации Ki-67 и онкопротеина p16INK4A в дифференциальной диагностике плоскоклеточных интраэпителиальных поражений и рака шейки матки = The degree of expression OF Ki-67 protein and oncoprotein p16INK4A in differential diagnosis of squamous intraepithelial lesions and cancer of cervix uteri". Journal of Education, Health and Sport 5, № 7 (2015): 71–90. https://doi.org/10.5281/zenodo.19213.

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<strong>Pliten</strong> <strong>O</strong><strong>. </strong><strong>N</strong><strong>. Степень экспрессии белка пролиферации </strong><strong>Ki</strong><strong>-67 и онкопротеина </strong><strong>p</strong><strong>16</strong><strong><sup>INK</sup></strong><strong><sup>4</sup></strong><strong><sup>A</sup></strong> <strong>в дифференциальной диагностике плоскоклеточных интраэпителиальных поражений и рака шейки матки = </strong><strong>The degree of expression OF Ki-67 protein and oncoprotein </strong><strong>p16<sup>INK4A</sup> </strong><strong>in differential diagnosis of squamous </strong><

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del Pino, Marta, Adriana Sierra, Lorena Marimon, et al. "CADM1, MAL, and miR124 Promoter Methylation as Biomarkers of Transforming Cervical Intrapithelial Lesions." International Journal of Molecular Sciences 20, no. 9 (2019): 2262. http://dx.doi.org/10.3390/ijms20092262.

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Background: Squamous intraepithelial lesions/cervical intraepithelial neoplasias (SIL/CIN) are high-risk human papilloma virus (hrHPV)-related lesions which are considered as high grade (HSIL/CIN2-3) or low grade (LSIL/CIN1) lesions according to their risk of progression to cervical cancer (CC). Most HSIL/CIN2-3 are considered as transforming hrHPV infections, so truly CC precursors, although some clear spontaneously. hrHPV testing has a high sensitivity for the detection of HSIL/CIN2-3 but a relatively low specificity for identifying transforming lesions. We aimed to determine whether the com

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Parwanto, ML Edy. "Kanker serviks dan gen Fas-promoter-670." Jurnal Biomedika dan Kesehatan 2, no. 3 (2019): 90–91. http://dx.doi.org/10.18051/jbiomedkes.2019.v2.90-91.

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Kanker serviks merupakan keganasan pada serviks. Jenis kanker tersebut terjadi pada perempuan dan masih menjadi masalah di Indonesia. Indonesia merupakan negara urutan ke 4 di Asia Tenggara dengan insiden kanker serviks terbesar setelah Kamboja, Myanmar dan Thailand. Berdasar data statistik tahun 2012, tingkat insidensi (incidence rate) kanker serviks di Indonesia 17 per 100.000 perempuan per tahun.(1) Telah terbukti bahwa penyebab primer terjadinya kanker serviks yaitu virus papilloma atau yang lebih dikenal dengan istilah “human papillomavirus (HPV)”. Terdapat beberapa jenis serotype H

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Villanueva-Duque, José Alfredo, Isis Carolina Castro-Valdés, and Nancy García-Cervantes. "Factores ginecoobstétricos y sociales para el desarrollo de neoplasias intraepiteliales cervicales." Revista Médica del Instituto Mexicano del Seguro Social 62, no. 5 (2024): e5848. https://doi.org/10.5281/zenodo.12667984.

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<strong>Resumen</strong> <strong>Introducción:</strong> las neoplasias intraepiteliales cervicales (NIC) anteceden al cáncer cervicouterino y se asocian a factores de riesgo que pueden estar presentes en la población, lo que contribuye a que se lleven a cabo el diagnóstico y tratamiento oportunos. <strong>Objetivo:</strong> identificar los factores de riesgo asociados para el desarrollo de NIC en mujeres atendidas en el primer nivel de atención médica. <strong>Material y métodos: </strong>se hizo un estudio transversal y retrospec

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Mehlhorn, Grit, Carla Schulmeyer, Martin Koch, Simone Renner, Paul Gaß, and Matthias Beckmann. "Diagnostik und Therapie des Vulvakarzinoms." Der Klinikarzt 46, no. 05 (2017): 212–16. http://dx.doi.org/10.1055/s-0043-109596.

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Mit einer Inzidenz von 5,8/100 000 Frauen/Jahr ist das Vulvakarzinom das vierthäufigste Genitalkarzinom der Frau. Meist werden Vulvakarzinome in einem frühen Stadium diagnostiziert. Häufigstes Symptom ist der therapieresistente Pruritus, perineale Schmerzen und/oder beim Sitzen, Dysurie und Brennen. Bei der klinischen Inspektion sollte das komplette äußere Genitale mit Vagina, Perineum, Anus sowie die Zervix inspiziert werden. Liegt eine VIN1, LSIL (vulväre intraepitheliale Neoplasie Grad 1, low-grade squamous intraepithelial lesion) ohne Symptome vor, sind regelmäßige Kontrollen ausreichend.

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Wellenhofer, Alfred, and Hermann Brustmann. "Expression of Human Telomerase Reverse Transcriptase in Vulvar Intraepithelial Neoplasia and Squamous Cell Carcinoma: An Immunohistochemical Study With Survivin and p53." Archives of Pathology & Laboratory Medicine 136, no. 11 (2012): 1359–65. http://dx.doi.org/10.5858/arpa.2011-0440-oa.

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Context.—Human telomerase reverse transcriptase (hTERT), an enzyme that enables cells to overcome replicative senescence and to divide indefinitely, is overexpressed in many cancers and their precursor lesions. Objective.—To test whether hTERT expression is related to neoplastic progression and resistance to apoptosis in vulvar epithelia. Design.—Immunoexpression of hTERT was evaluated in 101 formalin-fixed, paraffin-embedded archival vulvar epithelia consisting of normal squamous vulvar epithelia (n = 25), lichen sclerosus (n = 10), high-grade classic vulvar intraepithelial neoplasia (n = 16)

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Preti, Mario, Manon Van Seters, Mario Sideri, and Marc Van Beurden. "Squamous Vulvar Intraepithelial Neoplasia." Clinical Obstetrics and Gynecology 48, no. 4 (2005): 845–61. http://dx.doi.org/10.1097/01.grf.0000181738.37911.03.

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Bejarano, Pablo A., Marylise Boutros, and Mariana Berho. "Anal Squamous Intraepithelial Neoplasia." Gastroenterology Clinics of North America 42, no. 4 (2013): 893–912. http://dx.doi.org/10.1016/j.gtc.2013.09.005.

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Khan, Kelly A., Debora A. Smith, and Michael J. Thrall. "Only a Small Fraction of High-Grade Cervical Lesions Are Discovered After an Interpretation of Atypical Squamous Cells of Undetermined Significance When Using Imager-Assisted, Liquid-Based Papanicolaou Tests and the Bethesda 2001 System." Archives of Pathology & Laboratory Medicine 137, no. 7 (2012): 936–41. http://dx.doi.org/10.5858/arpa.2012-0358-oa.

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Context.—Previous work has reported that most high-grade cervical neoplasia is seen in patients with preceding Papanicolaou test results of atypical squamous cells of undetermined significance. This information was based on conventional test results and the Bethesda 1991 reporting system and was determined before the current treatment guidelines. Objective.—Our objective was to perform a retrospective review of all histologically confirmed, high-grade cervical neoplasia to determine the diagnosis of the preceding liquid-based Papanicolaou test. Design.—A total of 189 histologically confirmed,

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Berceanu, Costin, Stefan Paitici, Sabina Berceanu, et al. "Colposcopic, Histologic and Immunohistochemical Assessment in Cervical Intraepithelial Lesions." Revista de Chimie 69, no. 8 (2018): 2245–50. http://dx.doi.org/10.37358/rc.18.8.6509.

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It is widely accepted that HPV infection precedes the occurrence of neoplastic disease in a varying time frame, and HPV testing can detect 30-100% more cervical precancers than conventional cytology and 20-50% more precancers than liquid-based cytology. Low-grade squamous intraepithelial lesions include the categories of mild dysplasia, respectively cervical intraepithelial neoplasia grade 1, and complementary, various descriptors indicating the presence of Human papilloma virus, such as koilocytotic atypia or condilomatous dysplasia. High-grade squamous intraepithelial lesions cytologically c

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Nikolaou, Marinos, Dimitra Koumoundourou, Panagiota Ravazoula, Margarita Papadopoulou, Georgios Michail, and Georgios Decavalas. "An immunohistochemical analysis of sex-steroid receptors, tumor suppressor gene p53 and Ki-67 in the normal and neoplastic uterine cervix squamous epithelium." Medical review 67, no. 7-8 (2014): 202–7. http://dx.doi.org/10.2298/mpns1408202n.

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Introduction. Malignant transformation of sex-steroid dependent tissues is associated with the loss of expression of sex steroid receptors as well as of the tumor suppression gene p53. The aim of this study is to evaluate the expression of sex-steroid receptors, p53 and Ki-67 in specimens from pre-malignant and malignant cervical epithelial lesions throughout the menstrual cycle. Material and Methods. Immunohistochemical staining was performed on formalin fixed, paraffin embedded tissue sections of normal squamous cervical epithelium, cervical intraepithelial neoplasia and invasive squamous ce

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G. B, Deepthi, and Gayathri Bhat N.V. "A CASE OF CERVICAL INTRAEPITHELIAL NEOPLASIA - MANAGEMENT THROUGH AYURVEDA." International Ayurvedic Medical Journal 9, no. 12 (2021): 3143–50. http://dx.doi.org/10.46607/iamj3609122021.

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Introduction – Cervical cancer is the 2nd most leading prevalent cancer in India. There are an estimated 123,000 new cases of cervical cancer in India every year with 67,000 deaths in women alone. Cervical cancer in Recent studies shows that screening of cervical cancer reduces the disease incidence and disease mortality by 50%. Low- grade squamous intraepithelial lesion (LSIL) is a common abnormal result on a Pap smear cervical test. It’s also known as mild dysplasia. Methodology – Here is a case report of a patient aged 26yrs with complaints of white discharge per vagina with severe itching,

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Kepuladze, Shota, N. Nikolaishvili, George Chichua, and George Burkadze. "Molecular markers of the progression of conjunctival neoplastic epithelial lesions and its correlation with P16 and HPV expression." Indian Journal of Pathology and Oncology 10, no. 1 (2023): 40–43. http://dx.doi.org/10.18231/j.ijpo.2023.007.

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Epithelial lesions of the conjunctiva include both benign and transitional malignant and malignant lesions., Therefore, it is important to identify molecular markers of malignant progression of these lesions.The aim of our study was to study molecular markers determining the risk of progression of epithelial neoplastic processes of the conjunctiva. The following markers were detected by standard immunohistochemical methods: Ki67, PHH3, Bcl2, P16, HPV16/18, P53, P63 and CK7.A squamous-epithelial index was also derived by evaluating standard hematoxylin-eosin (H&E)-stained fluorescence and t

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Zalewski, Kamil, Marcin Misiek, Artur Kowalik, et al. "Normalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma." Tumor Biology 39, no. 11 (2017): 101042831771714. http://dx.doi.org/10.1177/1010428317717140.

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The role of circulating microRNAs as a promising tool for diagnosing cancer and monitoring anticancer therapies has been widely studied in the past decades. To date, no suitable reference microRNAs for normalizing quantitative real-time polymerase chain reaction assays has been identified in vulvar intraepithelial neoplasia lesions and vulvar squamous cell carcinoma. The purpose of this study was to select appropriate references for gene expression studies in plasma of patients with these lesions. Expression levels of six microRNAs—hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p,

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Santos-Antunes, J., E. Dias, R. Coelho, et al. "High-grade anal intraepithelial neoplasia treated with endoscopic submucosal dissection: a case report." Acta Gastro Enterologica Belgica 85, no. 1 (2022): 108–10. http://dx.doi.org/10.51821/85.1.8192.

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Anal intraepithelial neoplasia is a premalignant lesion for anal squamous cell carcinoma. Current treatment options, consisting of topical therapy and local ablative procedures with electrocautery or radiofrequency ablation, are effective although recurrence rates are high. Experience with endoscopic submucosal dissection for anal lesions is limited, with only a few cases of anal intraepithelial neoplasia and early anal squamous cell carcinoma. We present a 65-year-old woman with high-grade anal intraepithelial neoplasia successfully removed by endoscopic submucosal dissection with no complica

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Zhao, Chengquan, Shuping Zhao, Amer Heider, and R. Marshall Austin. "Significance of High-Risk Human Papillomavirus DNA Detection in Women 50 Years and Older With Squamous Cell Papanicolaou Test Abnormalities." Archives of Pathology & Laboratory Medicine 134, no. 8 (2010): 1130–35. http://dx.doi.org/10.5858/2009-0624-oa.1.

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Abstract Context.—Data on cytologic screening and follow-up disproportionately reflect findings from frequently screened younger women, and data from screened women 50 years and older using newer screening technologies remain limited. Objective.—To better understand the utility of adjunctive high-risk human papillomavirus (hrHPV) testing for disease risk stratification in women 50 years and older with a range of liquid-based cytology, abnormal, squamous cell Papanicolaou test results. Design.—Liquid-based cytology cases interpreted as high-grade squamous intraepithelial lesion (HSIL); low-grad

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Tarini, Emine Zeynep, and Hasan İlyas Özardali. "Immunohistochemical expression of progesterone receptor and C-erb-B2 in cervical squamous cell carcinoma and epithelial dysplasia." Journal of Clinical and Investigative Surgery 6, no. 1 (2021): 43–47. http://dx.doi.org/10.25083/2559.5555/6.1.8.

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Objective. We aimed to demonstrate whether the immunohistochemical expression of C-erb-B2 and progesterone receptors are valuable in the diagnosis of intraepithelial cervical neoplasia and squamous cell carcinoma. Methods and Results. Our retrospective study, a total of 84 cases diagnosed as squamous cell carcinoma and cervical intraepithelial neoplasia during 2005-2009, at the pathology department of Harran University, was investigated and stained with immunohistochemistry. Progesterone receptor was stained positive in 5 of 21 cervical intraepithelial neoplasia I. As a result of the statistic

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Jain, Parul, Aastha Singh, Avilasha Mohapatra, Ritu Arora, and Gahan A. Reddy. "Ocular Surface Squamous Neoplasia – An Update on Diagnostic Modalities and Management." Delhi Journal of Ophthalmology 33, no. 3 (2023): 186–90. https://doi.org/10.4103/dljo.dljo_121_23.

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Ocular surface squamous neoplasia (OSSN) encompasses a group of squamous neoplasms of conjunctival and corneal epithelium such as conjunctival intraepithelial neoplasia, corneal epithelial dysplasia and squamous cell carcinoma. Patients with OSSN present with decreased visual acuity, irritation in the eye, and an ocular surface lesion with varied clinical morphologies, associated prominent feeder vessels, and often a keratin plaque. While the definitive diagnosis of OSSN is histopathological, imaging modalities such as optical coherence tomography (OCT), OCT-angiography, and ultrasound biomicr

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Brum, Vivian de Oliveira Rodrigues, Alessandra de Souza Oliveira Tricoti, Gabriel Duque Pannain, Denise Gasparetii Drumond, and Isabel Cristina Gonçalves Leite. "Cytology-based Screening for Anal Intraepithelial Neoplasia in Immunocompetent Brazilian Women with a History of High-Grade Cervical Intraepithelial Neoplasia or Cancer." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 44, no. 07 (2022): 678–85. http://dx.doi.org/10.1055/s-0042-1743163.

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Abstract Objective To determine the prevalence and possible variables associated with anal intraepithelial neoplasia and anal cancer in immunocompetent women with high-grade cervical intraepithelial neoplasia. Methods A cross-sectional study involving immunocompetent women with a histological diagnosis of high-grade cervical intraepithelial neoplasia and cervical cancer, conducted between January 2016 and September 2020. All women underwent anal cytology and answered a questionnaire on characterization and potential risk factors. Women with altered cytology were submitted to anoscopy and biops

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Léonard, Boris, Frederic Kridelka, Katty Delbecque, et al. "A Clinical and Pathological Overview of Vulvar Condyloma Acuminatum, Intraepithelial Neoplasia, and Squamous Cell Carcinoma." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/480573.

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Condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma are three relatively frequent vulvar lesions. Condyloma acuminatum is induced by low risk genotypes of human papillomavirus (HPV). Vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma have different etiopathogenic pathways and are related or not with high risk HPV types. The goal of this paper is to review the main pathological and clinical features of these lesions. A special attention has been paid also to epidemiological data, pathological classification, and clinical implications of these diseases.

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Lytwyn, Alice, John W. Sellors, James B. Mahony, et al. "Adjunctive Human Papillomavirus Testing in the 2-Year Follow-up of Women With Low-Grade Cervical Cytologic Abnormalities: A Randomized Trial and Economic Evaluation." Archives of Pathology & Laboratory Medicine 127, no. 9 (2003): 1169–75. http://dx.doi.org/10.5858/2003-127-1169-ahptit.

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Abstract Context.—Although human papillomavirus (HPV) testing may aid in managing low-grade abnormality on screening cervical cytology, patient compliance with repeat testing programs requires consideration. Objectives.—To determine effectiveness and costs of repeated Papanicolaou (Pap) test and oncogenic HPV testing for detecting cervical intraepithelial neoplasia 2 or 3. Design.—We conducted a randomized controlled trial of combined Pap test and cervical HPV testing by Hybrid Capture 1 test compared with Pap test alone; tests were performed every 6 months for up to 2 years. The study end poi

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