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Dissertations / Theses on the topic 'SRD5A1'

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1

Tijani, Omolara Khadijat. "Glucocorticoids and Intracrine Cortisol Metabolism in human Islets : Impact on Glucose Stimulated Insulin secretion." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS061.

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Une exposition excessive aux glucocorticoïdes (GC), comme observée chez les patients recevant une corticothérapie, peut entraîner un dysfonctionnement des cellules β et un diabète chez jusqu'à 40% des patients. Dans l'obésité, une surexposition locale au cortisol secondaire à une altération du métabolisme du cortisol contribue à l'apparition du diabète. Des doses élevées de GC comme la dexaméthasone (DEX) inhibent la sécrétion d'insuline stimulée par le glucose (SISG), mais les effets de doses plus faibles et des autres GC, tels que l'hydrocortisone (HC) et la prednisone (PRED), restent peu ét
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2

Calais, Flávia Leme 1983. "Estudo dos genes SRD5A2 e 17BHSD3 em casos de ambiguidade genital em pacientes com cariótipo 46,XY." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317125.

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Orientador: Maricilda Palandi de Mello<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-17T10:04:15Z (GMT). No. of bitstreams: 1 Calais_FlaviaLeme_M.pdf: 2545885 bytes, checksum: 01651078ede5d0d74599fe9cf524b8bd (MD5) Previous issue date: 2010<br>Resumo: Para um correto desenvolvimento sexual masculino em humanos, é necessária a presença, entre outros, de dois hormônios esteróides: a testosterona (T) e a diidrotestosterona (DHT). A T é o hormônio responsável pelo desenvolvimento da genitália interna masculina, já a DH
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3

Medina-Cano, Daniel. "Study of the molecular bases underlying cerebellar defects with emphasis on protein N-glycosylation impairment." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2162&f=12708.

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Les anomalies cérébelleuses englobent un groupe de maladies rares affectant le fonctionnement du cervelet. La prévalence de ces défauts est estimée à 26 sur 10000 enfants en Europe. Ces maladies entraînent des troubles du mouvement (ataxie) et sont fréquemment associées à des déficiences intellectuelles, des défauts qui empêchent les patients touchés d'avoir une vie normale et qui peux entrainer une mortalité précoce. Pour la plupart de ces conditions, seul un traitement symptomatique est disponible. Outre le diagnostic génétique, utile pour faire face à de nouvelles grossesses, une compréhens
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Ferraz, Lucio Fabio Caldas. "Investigação molecular do gene da 5 alfa redutase tipo 2 (SRD5A2) em pacientes com pseudohermaforditismo masculino (PHM)." [s.n.], 1999. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316607.

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Orientador: Christine Hackel<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-07-25T03:14:28Z (GMT). No. of bitstreams: 1 Ferraz_LucioFabioCaldas_M.pdf: 8458264 bytes, checksum: 1216d86d4eeffa6fa581b32e0511d502 (MD5) Previous issue date: 1999<br>Mestrado
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5

Neves, Adriana Freitas. "Variações transcricionais dos genes AR, SRD5A2, KLK2, PCA3, KLK3 e PSMA e implicações no diagnóstico molecular do câncer de próstata." Universidade Federal de Uberlândia, 2007. https://repositorio.ufu.br/handle/123456789/15771.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>CHAPTER I - Prostate cancer is a common disease in the world and in some countries it is one of the main causes of male population mortality. Some molecular markers have been associated with prostate carcinogenesis. To observe changes in transcript levels of the AR, SRD5A2, KLK2, PSMA and PCA3 genes, the mRNA was analyzed in tissues with prostatic adenocarcinoma (PCa, N= 48) and benign prostatic hyperplasia (BPH, N= 25), performed through a differential multiplex RT-PCR assay. Significant differences were observed in the relative e
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6

Amorin, Bruna. "Polimorfismo V89L do gene 5 α-redutase tipo II (SRD5A2) e a associação com o risco de câncer de próstata :". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/115564.

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Introdução: A pesquisa por marcadores genéticos de susceptibilidade a doenças geralmente focam um gene baseado nas propriedades e vias metabólicas de seus produtos protéicos, assim, genes envolvidos na biossíntese de andrógenos podem identificar possíveis alterações na carcinogênese prostática. Diferenças étnicas em polimorfismos apresentam um papel no metabolismo de hormônios e podem acometer diferentes raças no risco de desenvolver câncer de próstata. A 5 alfaredutase (SRD5A2) é a enzima responsável por catalisar irreversivelmente a conversão da testosterona no principal androgênio prostátic
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7

Lindström, Sara. "Genetic variation and prostate cancer : population-based association studies in Sweden." Doctoral thesis, Umeå universitet, Strålningsvetenskaper, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1329.

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Prostate cancer constitutes the most common malignancy and the most common cause of cancer‐related death in Swedish men. A large body of evidence suggests that inherited genetic variants contribute to both development and progression of prostate cancer. The aim of this thesis is to identify genetic variants that alter prostate cancer risk and progression. All papers included in this thesis are based on a Swedish population‐based case‐control study (CAPS) comprising 2,965 incident prostate cancer cases and 1,823 controls. In paper I, we investigated if genetic variants in the E‐cadherin gene al
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8

Rang, Wei. "Emotional Movements Analysis and Classification with SRDA." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/theses/2179.

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Motion databases are becoming larger with the development of hardware and software, applications based on these data have been widely used in many different areas, such as movies, animations, videos games, sports as well as computer vision and robotics. All those applications had made motion analysis and classification essential for better motion composition. However, in order to achieve a good connectivity between every motion and emotion behind it, it is totally important to understand human behavior, even if human movements are complex and hard to describe completely. In this thesis, we mak
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9

Dmitrienko, Alexandra [Verfasser], Michael [Akademischer Betreuer] Waidner, and Srdjan [Akademischer Betreuer] Capkun. "Security and privacy aspects of mobile platforms and applications / Alexandra Dmitrienko. Betreuer: Michael Waidner ; Srdjan Čapkun." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2015. http://d-nb.info/111191026X/34.

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10

Ladenbauer, Josef [Verfasser], Klaus [Akademischer Betreuer] Obermayer, Viktor [Akademischer Betreuer] Jirsa, and Srdjan [Akademischer Betreuer] Ostojic. "The collective dynamics of adaptive neurons : insights from single cell and network models / Josef Ladenbauer. Betreuer: Klaus Obermayer. Gutachter: Viktor Jirsa ; Srdjan Ostojic." Berlin : Technische Universität Berlin, 2015. http://d-nb.info/1078310505/34.

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11

Kasper, Timo [Verfasser], Christof [Gutachter] Paar, and Srdjan [Gutachter] Capkun. "Security analysis of pervasive wireless devices : physical and protocol attacks in practice / Timo Kasper ; Gutachter: Christof Paar, Srdjan Capkun ; Fakultät für Elektrotechnik und Informationstechnik." Bochum : Ruhr-Universität Bochum, 2013. http://d-nb.info/1226425631/34.

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12

Luthman, Anna Siri Naemi. "Spectrally resolved detector arrays for multiplexed biomedical fluorescence imaging." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274904.

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The ability to resolve multiple fluorescent emissions from different biological targets in video rate applications, such as endoscopy and intraoperative imaging, has traditionally been limited by the use of filter-based imaging systems. Hyper and multispectral imaging facilitate the detection of both spatial and spectral information in a single data acquisition, however, instrumentation for spatiospectral data acquisition is typically complex, bulky and expensive. This thesis seeks to overcome these limitations by using recently commercialised compact and robust hyper/multispectral cameras bas
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Dobricic, Srdjan [Verfasser]. "Sensitivity of an ocean atmosphere model of Adriatic Sea to coupling scheme and resolution of the atmospheric model / European Commission, Joint Research Centre, Institute for Environment and Sustainability Inland and Marine Waters Unit. vorgelegt von Srdjan Dobricic." Ispra : Inst. for Environment and Sustainability Inland and Marine Waters Unit, 2002. http://d-nb.info/967246164/34.

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14

"Cineastas Srdan Golubovic y Dunja Kusturica dictaron Master Class en la UPC." Universidad Peruana de Ciencias Aplicadas - UPC, 2015. http://hdl.handle.net/10757/564231.

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La Universidad Peruana de Ciencias Aplicadas (UPC), a través de su carrera de Comunicación Audiovisual y Medios Interactivos y el V Festival de Cine AL ESTE DE LIMA 2014, recibió la visita de la cineasta Dunja Kusturica -hija del laureado cineasta Emir Kusturica- y de Srdan Golubovic, reconocido cineasta serbio, el pasado 9 de mayo para dictar un Master Class sobre sus guiones cinematográficos. Durante la presentación ambos cineastas brindaron a los asistentes pautas, anécdotas y recomendaciones al empezar a escribir un guión. En el transcurso del Master Class hubo variedad de preguntas so
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15

Yang, Yu-Ching, and 楊幼菁. "Plasma Testosterone, SRD5A2 Genetic Polymorphism and Risk of Hepatocellular Carcinoma among Men with Chronic Hepatitis B CAG-Repeat Length in the Androgen Receptor Gene and Female Hepatocellular Carcinoma." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/48774830180515489638.

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碩士<br>國立臺灣大學<br>流行病學研究所<br>88<br>Abstract Objective:The specific aims of this study were:1) to assess the risk of hepatocellular carcinoma (HCC) associated with plasma testosterone level and the V89L polymorphism in steroid 5α-reductase type 2 (SRD5A2) gene among HBsAg-positive men in a nested case-control study;and 2) to investigate the association between a microsatellite( (CAG)n) within exon 1 of the androgen receptor(AR) gene and HCC in women by use of case-control study. Methods:A total of 110 incident cases of HCC and 110 matched controls identified from a cohort of
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16

Lin, Sheng-kai, and 林聖凱. "An association study on the genetic polymorphisms in IGF2, IGFBP3 and SRD5A2 and responsiveness to booster hepatitis B vaccination in residual anti-HBs-seronegative senior high school students." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/44600007153381764381.

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碩士<br>慈濟大學<br>原住民健康研究所<br>94<br>In Taiwan, the implement of universal hepatitis B (HB) vaccination program (UHBVP) had successfully reduced the rates of HBsAg-seropositivity and hepatocellular carcinoma incidence in children. However, approximately 5-10% of vaccinated-children were low- or non-response to hepatitis B vaccine. Several researches had shown that there were gender and ethnic variations in the response to hepatitis B vaccine. The non-response rate was higher in male children than in female children and the efficacy of HB vaccination was lower in indigenous children than in Hans chi
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17

Petkovic, Srdan [Verfasser]. "Der nationale Diskurs unter Einfluß von Kriegspropaganda, Kirche und Folklorismus. : zur Entwicklung serbischer Selbstwahrnehmung / von Srdan Petkovic." 2003. http://d-nb.info/969853394/34.

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18

Hámor, Peter. "Vliv dávkování genu Nkx2.5 na vývoj a elektrofyziologii srdce u myši." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-343837.

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Role of Nkx2.5 on development and electrophysiology of the mouse heart Prague 2015 Bc. Peter Hámor ABSTRACT The objective of this thesis is to investigate the role of Nkx2.5 gene dosage on electrophysiology of the mouse heart in prenatal stage of its development, in which the physiological functions of the heart fail to function properly. The main goal of this work is to search for differences in conduction of electric impulses through the embryonic mouse heart according to their genotype. Special method of capturing the conduction of electric impulse through myocardium was used for this purpo
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19

Hámor, Peter. "Role genu Nkx2.5 v morfogenezi a elektrofyziologii srdce u myši." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-351482.

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Role of Nkx2.5 in development and electrophysiology of the mouse heart Prague 2016 Peter Hámor, B.S. ABSTRACT The objective of this thesis is to investigate the role of Nkx2.5 gene dosage on electrophysiology of the mouse heart in prenatal stage of its development. The main goal of this work is to search for differences in conduction of electric impulses through the embryonic mouse hearts of different genotype. Special method of capturing the conduction of electric impulse through myocardium, called optical mapping, was used to visualize the electrical activity. Thanks to this method I was abl
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黃文灝. "探討影響台灣婦女生育之因素-以SRDA 2006 婦女婚育與就業調查資料為例". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/93256473877177442372.

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