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Dissertations / Theses on the topic 'SS sickle cell disease'

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Published: 5 June 2025

Last updated: 2 August 2025

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1

Lalanne-Mistrih, Marie-Laure. "Caractérisation des profils lipidiques plasmatiques des patients drépanocytaires guadeloupéens SS et SC à l'état stable. Profil lipidique et hémorhéologique des complications du sous-phénotype hyperhémolytique/vasculopatie et hypervisqueux/vaso occlusif. : Profil lipidique et hémorhéologique des complications du sous-phénotype hyperhémolytique/vasculopathie et hypervisqueux/vaso occlusif." Thesis, Antilles, 2019. http://www.theses.fr/2019ANTI0437.

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Les patients drépanocytaires ont un profil lipidique spécifique, à priori non athérogène.En 2009 est découvert qu’un taux d’apolipoprotéine AI et de HDL-cholestérol abaissés et de triglycérides élevés (HTG), constitue un profil lipidique plus souvent associé à une hypertension artérielle pulmonaire. Notre travail de thèse a consisté en l’étude, à l’état stable, des profils lipidiques des cohortes d’adultes drépanocytaires homozygotes SS (HbS/HbS) et hétérozygotes composites SC (HbS/HbC), à l’unité transversale de la Drépanocytose du CHU de la Guadeloupe, comparés ensuite à celui de la populati

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2

Tozatto, Maio Karina. "Immunogenetics in sickle cell disease." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCC093.

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La drépanocytose est l’hémoglobinopathie héréditaire la plus fréquente, causée par un polymorphisme unique d’un nucléotide (SNP) dans le gène de la beta-globine (HBB). Ce SNP détermine la synthèse de l’hémoglobine S, qui polymérise lorsqu’elle est soumise au stress, et ceci change la forme des hématies drépanocytaires en faucille. Les drépanocytes sont moins déformables, plus adhérents à l’endothélium, et plus susceptibles à l’hémolyse. Les complications cliniques de la drépanocytose peuvent être expliquées par l’interaction entre la vaso-occlusion, l’hémolyse et l’activation inflammatoire rés

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3

Hays, Mary Margaret. "Stem cell transplant for sickle cell disease." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12117.

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Thesis (M.A.)--Boston University<br>Background: Sickle cell disease (SCD) is the most common inherited blood disorder in the United States. As SCD can cause significant morbidity and decrease in life expectancy, further research on curative options is of great interest. Hematopoietic stem cell transplant (HSCT) is the only treatment option offering a chance of cure, but the risks of treatment are not negligible. Because the outcomes of HSCT are best when the procedure is performed at a younger age, understanding what parents know about transplant, their opinion on this option and the risks the

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4

Kawadler, J. M. "Neuroimaging biomarkers in paediatric sickle cell disease." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1464063/.

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Sickle Cell Disease (SCD) is a collection of genetic haemoglobinopathies, the most common and severe being homozygous sickle cell anaemia. In the UK, it has been estimated that 1 in 2000 children are born with SCD. The disease is characterised by chronic anaemia, recurrent pain crises and vascular occlusion. Neurologically, there is a high incidence of stroke in childhood, as well as cognitive dysfunction. Newborn screening programmes and preventative treatments have allowed a much longer lifespan; however recently, neurological research has shifted to characterising subtler aspects of brain d

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5

Gavlak, J. C. D. "Sleep in children with sickle cell disease." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1528622/.

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BACKGROUND: Sickle Cell Anaemia (SCA) or homozygosity for the sickle haemoglobin gene (HbSS) is the most common genetic condition in the UK. A high prevalence of Sleep Disordered Breathing (SDB) in SCA is widely accepted but there is a lack of unselected population based studies. As Polysomnography (PSG) is expensive, screening for SDB using a robust tool, e.g. the Delta 12 (Δ12) index and 3% Oxygen Desaturation Indices (ODI) calculated from home pulse oximetry, should be validated. Elevated Cerebral Blood Flow Velocity (CBFV) is a predictor of stroke in SCA, and may be associated with SDB. ME

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6

Gardner, Catherine Joanne. "Genotype-phenotype correlation in sickle cell disease." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/genotypephenotype-correlation-in-sickle-cell-disease(07a190be-c88a-41f2-8e74-e063d85919a3).html.

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Sickle cell disease (SCD) has a complex pathophysiology initiated by the polymerisation of deoxy-sickle-haemoglobin. The single nucleotide change underpinning SCD does not account for the vast range and severity of SCD complications. This clinical heterogeneity is only partly explained by the genetic variability of fetal haemoglobin gene levels and co-inheritance of α- thalassemia. Although environmental factors also contribute to the clinical complexity of SCD, further genetic modifiers of SCD severity exist but are yet to be determined. Genetic association studies have been boosted recently

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7

Mackey, Michelle Noble. "Understanding Parents' Disease-Managing Strategies for Children With Sickle Cell Disease." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6610.

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Sickle cell disease (SCD) is one of the most difficult and stressful chronic diseases for parents of afflicted children to manage. Managing SCD can be traumatic for parents particularly if they have no specific coping strategies for managing the disease or ensuring the child visits the doctor as scheduled. The use of certain coping strategies may affect the parents' and patients' perceptions of the illness and influence their decisions regarding treatment, which can have a lasting impact on their lives. Effective parental strategies such as positive thinking can aid in disease management, but

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8

Edmond, A. M. "The spleen in sickle cell disease in childhood." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598759.

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9

Singhal, Atul. "Growth and metabolism in homozygous sickle cell disease." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288009.

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10

Indik, Julia H., Vineet Nair, Ruslan Rafikov, et al. "Associations of Prolonged QTc in Sickle Cell Disease." PUBLIC LIBRARY SCIENCE, 2016. http://hdl.handle.net/10150/622120.

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Sudden death is a leading cause of mortality in sickle cell disease, implicating ventricular tachyarrhythmias. Prolonged QTc on an electrocardiogram (ECG), commonly seen with myocardial ischemia, is a known risk for polymorphic ventricular tachycardia (VT). We hypothesized that prolonged QTc is associated with mortality in sickle cell disease. ECG were analyzed from a cohort of 224 sickle patients (University of Illinois at Chicago, UIC) along with available laboratory, and echocardiographic findings, and from another cohort of 38 patients (University of Chicago, UC) for which cardiac MRI and

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11

JÃnior, Geraldo Bezerra da Silva. "Renal abnormalities in patients with sickle cell disease." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10491.

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nÃo hÃ<br>ABSTRACT Background - Kidney abnormalities are one of the main chronic complications of sickle cell disease (SCD). The aim of this study is to investigate the occurrence of renal abnormalities among patients with SCD. Methods - This is a cohort study with 26 SCD patients followed in a medical center in Fortaleza, CearÃ, Brazil. Urinary acidification and concentration tests were performed using calcium chloride (CaCl2), and after a 12h period of water and food deprivation. Fractional excretion of sodium (FENa), transtubular potassium gradient (TTKG) and solute free water reabsorption

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12

Wu, Li-Chen. "Correction of sickle cell disease by homologous recombination." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/wu.pdf.

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13

Matthie, Nadine. "Sickle Cell Disease: The Role of Self-Care Management." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4538.

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Abstract Sickle cell disease is the most common genetic disorder in the United States. Approximately 90% of the hospitalizations in this patient population occur due to the most common complication, pain crises. Prevention of these crises is therefore essential and requires the patient to assume an active role in his or her disease management. Studies suggest that further research is needed to examine the self-care management process and to identify factors influencing self-care behaviors. The relationships among these factors must be clearly defined before interventions to improve self-ca

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14

Riddington, Ceri Joanne. "Systematic reviews and clinical trials in sickle cell disease." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399217.

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15

Sylvester, Karl Peter. "Pulmonary function abnormalities in children with sickle cell disease." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424442.

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16

AlJuburi, Ghida. "Sickle cell and the burden of disease in England." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/28116.

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Background Sickle cell disorders (SCD) are the most common inherited blood disorders in England. Without prompt diagnosis and proper treatment, they can be a serious source of morbidity and mortality. Sickle cell diseases affect mainly black minority and ethnic populations, and have so far received relatively low priority from a health policy perspective. Antenatal and newborn screening, the development of minimum standards, antibiotic prophylaxis, comprehensive immunisations, and preventive diagnostic tests have positively influenced SCD management. There remains an unclear picture as to the

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17

Garrett, Kevin C. "Sickle cell disease and the family: a phenomenological study." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/17328.

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Doctor of Philosophy<br>Department of Family Studies and Human Services<br>Joyce A. Baptist<br>Sickle cell disease (SCD) is a prevalent, pervasive chronic illness. It is a hereditary condition that affects those of African, Mediterranean, Indian, Middle Eastern, and Hispanic/Latino descent. It causes extreme pain for patients and a myriad of other symptoms and complications. The medical issues associated with and the very nature of SCD has the potential to cause psychological distress and related problems for patients. Parents, caregivers, significant others, and family members are similarly a

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18

Lunt, Alan Charles. "Development of pulmonary function abnormalities in sickle cell disease." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/development-of-pulmonary-function-abnormalities-in-sickle-cell-disease(00af4d47-32d5-4145-9964-63ef4654f3b4).html.

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Sickle cell disease (SCD) is one of the commonest inherited disorders worldwide. Acute chest syndrome (ACS) is the commonest cause of death in young adults and pulmonary dysfunction is a major contributor to morbidity in aging adults with SCD, but the aetiology is poorly understood. The first four studies presented in this thesis test the hypothesis that pulmonary vascular abnormalities are involved in the pathogenesis of SCD-related lung disease. Significant associations were found between small vessel pulmonary vascular dimensions, lung function abnormalities and echocardiographic estimates

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19

Alexander, Helen. "Coping with Sickle Cell Disease Using Cognitive Behavior Therapy." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5157.

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This project focused on identifying the best evidence available on the use of cognitive behavior therapy (CBT) for pediatric patients and families with sickle cell disease (SCD) to improve their coping skills with pain management. This resulted from an identified gap in nursing practice regarding psychosocial support for this subset of hospitalized pediatric patients. The practice-focused question was whether there was evidence in the literature on the use of CBT techniques to improve parental coping skills with children who have chronic and life-threatening illness that could be utilized with

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20

Barach, Ilana. "Disease Management and Psychosocial and Health Outcomes in Pediatric Sickle Cell Disease." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337716279.

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21

Cooper, LaQuita Nichelle. "Sickle Cell Disease Pain Burden and Quality of Life Among Black Children in Mississippi." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/6000.

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Acute and chronic pain is a common hallmark of sickle cell disease (SCD) in children and adolescents, which can have a profound effect on their quality of life (QOL). However, this relationship is not well quantified. The purpose of this quantitative study was to examine the relationship between SCD pain burden and QOL among Black children ages 8-17 in Mississippi with SCD. The secondary aim was to compare children and caregiver reports of SCD pain burden and QOL with SCD. The social ecological model was used to identify personal factors that influence SCD pain burden and QOL of children with

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22

Eiymo, Mwa Mpollo Marthe-Sandrine. "Pulmonary Complications of Sickle Cell Disease Resulting from Erythroid Cell-Driven Signalling." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1406901116.

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23

Stewart, Kai Anika Djenaba. "An examination of African American college students' knowledge and attitudes regarding sickle cell disease and sickle cell disease carrier testing a mixed methods study /." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008r/stewart.pdf.

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24

Battle, Charity Michelle. "Comparing and contrasting different treatment modalities of sickle cell disease." Thesis, Boston University, 2012. https://hdl.handle.net/2144/31506.

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Thesis (M.A.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Sickle cell disease (SCD) is an autosomal recessive disorder affecting over 70,000 people in the United States. Following deoxygenation, red blood cells become deformed and appear in the characteristic sickle-

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25

Ola, Bolanle. "Living with sickle cell disease and depression in Lagos, Nigeria." Thesis, De Montfort University, 2016. http://hdl.handle.net/2086/12266.

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Sickle cell disease (SCD) and depression are each major public health issues globally. Nigeria currently has the largest proportion of people with SCD worldwide, with up to 150,000 annual births. This study highlights the limitations of previous studies, which only utilize the biomedical model in explaining SCD, and which pay insufficient attention to the lived experiences of people with SCD. Extant literature reports strong associations between SCD and depression, and locates the problem ‘only’ in terms of disease severity, levels of service utilization or alleged psychological maladjustment

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26

Mara, Prengler. "Magnetic resonance perfusion and cerebrovascular studies in sickle cell disease." Thesis, University College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418098.

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27

Al, Balushi Halima. "Novel approach towards pathogenesis and treatment of sickle cell disease." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288739.

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Sickle cell disease (SCD) is one of the most common genetic diseases worldwide. HbS polymerisation causes altered red blood cell (RBC) rheology and fragility, increase in blood viscosity with blockage of small blood vessels, and RBC membrane permeability changes. Excessive levels of cell-free Hb, high autoxidation of Hb, contribute to the production of reactive oxygen species (ROS) in SCD patients. In this work, oxidants showed direct and indirect effects on the main cation permeability pathways involved in dehydration of HbS/S RBCs - Psickle, the Gardos channel and the KCl cotransporter (KCC)

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Janse, van Rensburg P. J. "Paediatric cardiac anaesthesia in sickle cell disease : a case series." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/13790.

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Sickle cell disease (SCD) is the most common inherited haematological disorder, producing a mutation of the haemoglobin molecule known as haemoglobin S (HbS). The presence of HbS in the erythrocyte makes it prone to sickling - a process which may lead to vaso-occlusive injury, haemolysis and a hypercoagulable state. Sickling is precipitated by dehydration, hypoxia, hypothermia, acidosis and low flow states. Over time, multi-organ damage develops with significant morbidity and mortality. Paediatric patients with SCD and congenital heart defects may require anaesthesia for corrective cardiac sur

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29

Drasar, Emma Rachel. "Genetic and biological markers of severity in sickle cell disease." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/genetic-and-biological-markers-of-severity-in-sickle-cell-disease(7c1f16a0-0862-4311-ae7f-7842a85e915e).html.

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Sickle cell disease (SCD) is remarkable for the variability of its phenotype despite its genetic simplicity, with family and population studies indicating a strong genetic influence. The best characterised genetic modifiers are genes controlling HbF levels and co-inheritance of alpha-thalassaemia. Other genetic and biological factors may also influence disease severity and the development of complications. King’s Health Partners have the largest adult cohort of SCD patients in the United Kingdom, approximately 2400 patients. Characterising this group (using laboratory variables, evidence of cl

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30

Salmon, Anderson Tricia. "Sickle Cell Trait and Genetic Counseling." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/4020.

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Sickle cell trait (SCT) is a very prevalent disorder in the United States, especially among African Americans or people of African descent. However, even with the prevalence of the disorder, there are no standardized guidelines for providing patients with information about SCT and the implications of the disorder at physicals and well-check visits. The purpose of this evidence-based project was to increase awareness for African American patients 18-44 years old in the practice setting about SCT and to provide options for testing and genetic counseling. Kotter's contemporary change theory was u

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31

Perry, Angela. "Quality of life for caregivers of children with sickle cell disease." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002049.

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32

Lim, Crystal Marie Stack. "Pain, Quality of Life, and Coping in Pediatric Sickle Cell Disease." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/psych_diss/54.

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Introduction: Sickle cell disease (SCD) affects predominately African Americans and is one of the most prevalent diseases in the United States (Schecter, 1999). Research has not sufficiently examined whether pain associated with SCD impacts quality of life or whether coping impacts this relation. The purpose of this study was to examine the relation between pain and quality of life in children with SCD and to determine whether coping moderates the relation. A secondary aim was to examine associations between age and pain, quality of life, and coping. A final exploratory aim was to examine the

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33

Mohammed, Samir M. M. "Calcium metabolism in sickle cell disease : possible link with sicklaemic osteoporosis." Thesis, University of Salford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292910.

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34

Gbotosho, Oluwabukola Temitope. "Novel approaches to diagnosis, prognosis and pathogenesis of sickle cell disease." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708915.

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35

Al-Kitani, Mahfoodha. "Physiological responses to exercise in Omani children with sickle cell disease." Thesis, University of Bath, 2013. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577754.

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According to the national survey of genetic blood disorders, the prevalence of haemoglobinopathies in Oman is 9.5% with Sickle Cell Disease (SCD) and Sickle Cell Trait (SCT) representing two major public health concerns and having great impact on individuals’ lives as well as on society (Al-Riyami et al., 2001). Complications related to SCD arise owing to ischemic tissue injury and may result in organ dysfunction and premature death. Patients with SCD often experience painful crises (vaso-occlusion), renal disease, acute chest syndrome (ACS) and other lifethreatening conditions. Physical educa

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36

Higgins, John M. (John Matthew). "Mathematical and mechanical modeling of vaso-occlusion in sickle cell disease." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/38660.

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Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology, 2007.<br>Includes bibliographical references.<br>Vaso-occlusive crises cause most of the morbidity and mortality associated with sickle cell disease. The proximal causes of these occlusive events are not well understood. The risks and consequences of vaso-occlusion however are clear. Ten percent of sickle cell disease patients will have a stroke by the age of 20. Two thirds of sickle cell disease patients require more than one hospitalization per year for treatment of pain crises. The flow behavior of blood samples from sic

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Coleman, Beth. "Exploring the experience of pain in adults with sickle cell disease." Thesis, Canterbury Christ Church University, 2013. http://create.canterbury.ac.uk/12486/.

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Sickle Cell Disease (SCD) is England’s most common blood disorder whereby sickled shaped red blood cells block small blood vessels causing both acute and chronic pain. Currently there is poor understanding about the experience of SCD pain. Furthermore, there is a recognised difficult relationship between SCD patients and health care professionals (HCP) which has been found to prevent patients seeking medical assistance. Seven adults with SCD participated in semi-structured interviews regarding their experience of pain and receiving medical treatment. Interviews were transcribed and analysed us

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Al-Saqladi, Abdul-Wahab. "Sickle cell disease in Yemeni children : Clinical, biochemical and genetic aspects." Thesis, University of Liverpool, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526823.

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Goldstein, Alana L. "Transition Readiness in Adolescents and Young Adults with Sickle Cell Disease." Xavier University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=xavier1439143927.

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Westcott, Emilie. "Healthy Behaviors of Adolescents and Young Adults with Sickle Cell Disease." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504800267776992.

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Dahman, Bassam. "Evaluating Bilateral Phenomena: The Case of Pain in Sickle Cell Disease." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/1178.

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Bandeen, Timothy C. "Effects of sickle cell disease on growth of the craniofacial complexes. /." View the abstract Download the full-text PDF version View the full-text HTML version, 2005. http://etd.utmem.edu/ABSTRACTS/2005%5F001%5Fbandeen%5Findex.html.

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Thesis (M.S.)--University of Tennessee Health Sciences Center, 2005.<br>Spine title: Effects of sickle cell disease on growth of the craniofacial complexes. Appendices: leaves 162-414 Bibliography: leaves 145-161.

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43

Owotomo, Jejelola. "The Socioeconomic and Cultural Impact of Sickle Cell Disease in Nigeria." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2569.

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Sickle cell disease (SCD) is a genetic health condition that has continued to increase globally. SCD is prevalent in developing countries like Nigeria with 20 to 30% of the population living with SCD. The aim of this study was to explore the effect of the socioeconomic and cultural factors that affect the quality of life (QOL) of individuals with SCD in Nigeria. The framework for the study is secondary prevention. Secondary prevention allows for opportunities to improve QOL amongst people living with SCD focusing on the health beliefs, and socioeconomic wellbeing. A phenomenological approach w

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Busbee, Paula. "Geographical Effects on Adult Sickle Cell Disease Treatments, Morbidity, and Mortality." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2641.

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A small percentage of patients with sickle cell disease (SCD) have experienced an increase in life span by 10 years, while others with the same disease continue to die prematurely. The purpose of the study was to evaluate whether or not regional location was a barrier to care for adults with SCD in relation to emergency department visits and health outcomes at 16 and 21 years after the approval of hydroxyurea therapy as treatment. Secondary data were sourced and a retrospective quantitative correlational design was used to examine the effect of hydroxyurea treatment approval on emergency depar

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Fowora, Muinah Adenike. "Adherence to Self-Care Management of Sickle Cell Disease Among Caregivers." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2257.

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The self-care management of sickle cell disease (SCD) improves mortality rate; however, compliance with SCD self-care management remains a problem. The purpose of this study was to examine the knowledge and factors that influence compliance with SCD self-care management recommendations among caregivers of children with SCD. The health belief model was used as the theoretical foundation of this study, theorizing that caregivers' perceived susceptibility, severity, and benefits of SCD self-care management will influence compliance. The study used a quantitative research design. A cross-sectional

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GUOBADIA, EDWIN AHUNWAN. "The Effects of a Sickle Cell Disease Education Intervention Among College Students." ScholarWorks, 2015. http://scholarworks.waldenu.edu/dissertations/1682.

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Sickle cell disease (SCD) is a genetic disorder that affects millions of people worldwide. According to the Centers for Disease Control and Prevention, over 100,000 Americans have SCD, and more than 2 million Americans have a sickle cell trait (SCT). People with SCD are more likely than others to suffer premature mortality. Genetic screening is an important step in improving quality of life and increasing longevity for those with SCD. Early detection may lead to effective management of the disease and reduction of complicating factors. The purpose of this quasi-experimental study was to determ

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Guobadia, Edwin Ahunwan. "The Effects of a Sickle Cell Disease Education Intervention Among College Students." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/1697.

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Sickle cell disease (SCD) is a genetic disorder that affects millions of people worldwide. According to the Centers for Disease Control and Prevention, over 100,000 Americans have SCD, and more than 2 million Americans have a sickle cell trait (SCT). People with SCD are more likely than others to suffer premature mortality. Genetic screening is an important step in improving quality of life and increasing longevity for those with SCD. Early detection may lead to effective management of the disease and reduction of complicating factors. The purpose of this quasi-experimental study was to determ

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Nwachuku, Goldie Okechi Nwaru. "The Relationship Between Sickle Cell Support Group Status and Barriers to Care as Perceived by Parents of Children with Sickle Cell Disease." ScholarWorks, 2016. http://scholarworks.waldenu.edu/dissertations/2369.

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Abstract:

By examining barriers to care, health professionals can better understand what disparities exist between groups and who may be at greater risk for poor primary care. Researchers have highlighted the need for additional research that focuses on the extent of unmet needs for U.S. children with sickle cell disease (SCD). The purpose of this quantitative study was to compare the differences between parents who are in a SCD support group and those who are not. The theoretical framework of this study is based on the chronic care model and social support theory. A total of 128 parents of children wit

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Lane, Alicia Renee. "Macrophage Activation in Sickle Cell Disease: The Role of Sphingolipid Metabolism in the Disease State." Thesis, Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53732.

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Sickle cell disease (SCD) is a disorder in which defective hemoglobin causes sickling of red blood cells, inducing painful vaso-occlusive crises when blood flow is blocked at sites of red blood cell (RBC) clotting that can ultimately result in organ failure or death. This work demonstrates that sphingolipid metabolism is dysregulated in SCD and that this pathway can be targeted pharmacologically to prevent vaso-occlusion. We suggest a pathway in which the sickling of RBCs in SCD activates acid sphingomyelinase, altering the distribution and concentration of sphingolipids in the RBC membrane an

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Lizarralde, Iragorri Maria. "Impact of mechanical and oxidative stress on red blood cell properties in sickle cell disease." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC324.

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Le globule rouge est une cellule simple avec l’une des fonctions les plus importantes de l’organisme : participer aux échanges gazeux et fournir l’oxygène aux tissus. C'est un disque biconcave hautement élastique grâce à un réseau de protéines du cytosquelette et de protéines membranaires spécifiques. La fonction, ainsi que la structure des globules rouges sont altérées dans plusieurs pathologies humaines telles que les hémoglobinopathies et les anomalies de membrane. La drépanocytose est une maladie héréditaire génétique caractérisée par une hémoglobine anormale qui polymérise en conditions h

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