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Journal articles on the topic 'SSA antibodies'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Bossuyt, Xavier, Johan Frans, Ann Hendrickx, Godelieve Godefridis, René Westhovens, and Godelieve Mariën. "Detection of Anti-SSA Antibodies by Indirect Immunofluorescence." Clinical Chemistry 50, no. 12 (2004): 2361–69. http://dx.doi.org/10.1373/clinchem.2004.035964.

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Abstract Background: HEp-2 cells that overexpress the human 60-kDa SSA antigen have been used to improve sensitivity and specificity for the detection of anti-SSA antibodies by indirect immunofluorescence. We describe a survey on the detection of anti-SSA antibodies using a commercial substrate that overexpresses SSA. Methods: The evaluation was done on 18 371 consecutive samples submitted to the laboratory for detection of anti-nuclear antibodies, from which 188 anti-SSA antibody-containing and clinically documented samples were obtained. The presence of anti-SSA antibodies produced a distinc

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2

Wermuth, Douglas J. "Anti-Ro/SSA Antibodies." Archives of Dermatology 121, no. 3 (1985): 335. http://dx.doi.org/10.1001/archderm.1985.01660030057018.

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3

Urbanski, Geoffrey, Aline Gury, Pascale Jeannin, et al. "Discordant Predictions of Extraglandular Involvement in Primary Sjögren’s Syndrome According to the Anti-SSA/Ro60 Antibodies Detection Assay in a Cohort Study." Journal of Clinical Medicine 11, no. 1 (2022): 242. http://dx.doi.org/10.3390/jcm11010242.

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Electrophoresis-derived techniques for anti-SSA/Ro60 KDa (anti-SSA) antibodies detection have been progressively replaced by methods using non-native antigens. We aimed to compare the patients’ phenotypes and the occurrence of extraglandular manifestations in primary Sjögren’s syndrome according to the method used to detect anti-SSA antibodies. Sera from patients with a diagnosis of pSS according to ACR/EULAR 2016 criteria between 2008 and 2017 were tested for anti-SSA antibodies using methods with non-native antigens (magnetic bead multiplex assay; line immunoassays) and one with native antig

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Smeele, H. T., L. F. Perez-Garcia, J. M. J. Cornette, M. W. Schreurs, and R. Dolhain. "POS0541 LOW PREVALENCE OF SSA (anti-Ro) AND SSB (anti-La) AUTOANTIBODIES IN FEMALE RHEUMATOID ARTHRITIS PATIENTS WITH A WISH TO CONCEIVE." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 504.2–505. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2435.

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Background:The presence of SSA (anti-Ro) and SSB (anti-La) autoantibodies has important clinical implications for female patients with a wish to conceive. The association between maternal levels of these autoantibodies and complete congenital heart block and neonatal Lupus syndrome is well established. Currently guidelines advise to test for these antibodies in all Rheumatoid Arthritis (RA) patients with a wish to conceive (1).Objectives:The objective was to determine the prevalence and titers of SSA and SSB autoantibodies in female patients with rheumatoid arthritis and a wish to conceive or

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Yoshida, Akira, Shunya Nagata, Yuka Okazaki, Hironari Hanaoka, Takahisa Gono, and Masataka Kuwana. "Dissociating Autoantibody Responses against Ro52 Antigen in Patients with Anti-Synthetase or Anti-MDA5 Antibodies." Diagnostics 13, no. 24 (2023): 3621. http://dx.doi.org/10.3390/diagnostics13243621.

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We aimed to dissociate the autoantibody response against the Ro52 protein in patients with anti-synthetase or anti-melanoma differentiation-associated gene 5 (MDA5) antibodies to explore the potential roles of different anti-Ro52 autoantibody responses in disease subclassification. This study used a single-center, prospective myositis cohort involving 122 consecutive patients with anti-synthetase antibodies identified by RNA immunoprecipitation (RNA-IP) and 34 patients with anti-MDA5 antibodies detected using enzyme immunoassay (EIA). Anti-Ro52 antibodies were measured using commercial EIA kit

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Gaither, K. K., and J. B. Harley. "A shared idiotype among human anti-Ro/SSA autoantibodies." Journal of Experimental Medicine 169, no. 5 (1989): 1583–88. http://dx.doi.org/10.1084/jem.169.5.1583.

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Idiotypes and antiidiotypes are thought to be important immune regulators and have provided clues for the origin and pathogenicity of autoantibodies. Many lupus and Sjögren's syndrome patients, as well as most neonatal lupus infants with congenital heart block or dermatitis, have antibodies to the ribonucleoprotein Ro/SSA, which is one of a group of RNA-protein autoantigens commonly found in human lupus sera. To characterize the fine specificity of anti-Ro/SSA antibodies, a rabbit antidiotypic serum was prepared against polyclonal affinity purified anti-Ro/SSA F(ab')2. The resulting antiidioty

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Yoshimi, Ryusuke, Atsuhisa Ueda, Keiko Ozato, and Yoshiaki Ishigatsubo. "Clinical and Pathological Roles of Ro/SSA Autoantibody System." Clinical and Developmental Immunology 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/606195.

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Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. No

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8

Bason, C., I. Pagnini, A. Brucato, et al. "Congenital heart block and immune mediated sensorineural hearing loss: possible cross reactivity of immune response." Lupus 26, no. 8 (2016): 835–40. http://dx.doi.org/10.1177/0961203316682099.

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Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react with an epitope of SSA/Ro60 protein. Anti-Ro/SSA antibodies in pregnant women cross the placenta and reach the fetal tissues inducing an immune-mediated damage of the cardiac conduction system. We wanted to evaluate whether mothers with anti-Ro/SSA antibodies who gave birth to chi

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Carretero Bellon, Juan M., Laia Brunet-Garcia, Joan Sanchez de Toledo, and Stefano Congiu. "Neonatal Rupture of the Tricuspid Valve and Maternal Lupus: Is There a Correlation?" World Journal for Pediatric and Congenital Heart Surgery 13, no. 2 (2021): 260–63. http://dx.doi.org/10.1177/21501351211044128.

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Valve dysfunction is not widely recognized as a feature in newborns born to mothers with positive anti-Ro/SSA antibodies, and only scarce reports have suggested an association between rupture of the atrioventricular valve tensor apparatus and these maternal antibodies. We report the follow-up from fetal life to the time of postnatal surgery of a patient with severe tricuspid regurgitation due to a flail of the anterior tricuspid valve leaflet who was born to an anti-Ro/SSA antibodies positive mother.

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10

Franceschini, F., and I. Cavazzana. "Anti-Ro/SSA and La/SSB antibodies." Autoimmunity 38, no. 1 (2005): 55–63. http://dx.doi.org/10.1080/08916930400022954.

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11

Mattia, Elena, Ariela Hoxha, Marta Tonello, et al. "Detection of autoantibodies to the p200-epitope of SSA/Ro52 antigen. A comparison of two laboratory assays." Clinical Chemistry and Laboratory Medicine (CCLM) 56, no. 6 (2018): 927–32. http://dx.doi.org/10.1515/cclm-2017-0704.

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Abstract Background: Anti-p200 antibodies have been receiving growing interest in view of findings associating their presence to risk of fetal autoimmune congenital heart block (CHB). The study compares and evaluates the performance of two assays currently being used for their detection. Methods: One hundred and sixteen pregnant women positive for anti-SSA/Ro52 antibodies were considered as the study population. Fifty women negative for anti-SSA/Ro52 antibodies were considered as the control population. Anti-p200 antibodies were analyzed using two home-made ELISA assays: one with biotinylated

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12

Groseanu, L., N. Cristina, D. Nicoara, et al. "POS1320 ANTI-RO/SSA ‑ POSITIVE SYSTEMIC SCLEROSIS - COMMONLY ASSOCIATED CLINICAL AND SEROLOGICAL FEATURES INDEPENDENTLY FROM THE UNDERLYING DISEASE." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1010.1–1010. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5008.

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BackgroundThe significance of anti-Ro antibodies in systemic sclerosis (SSc) is still unclear as their presence could represent an epiphenomenon of the strong immune response in severe visceral involvement or directly participate in tissue damages in SSc patients. Recent data suggest that the presence of anti-SSA/Ro antibodies is an independent risk factor for worse pulmonary outcome and higher all-cause mortality in patients with SSc[1].ObjectivesTo determine the frequency of anti-SSa/Ro antibodies in a cohort of SSc patients and its association with clinical, serological features and surviva

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Pepper, Elizabeth, Lilian Vilar, and Ian M. Ward. "Clinical Characteristics and Prognostic Value of Ro52/SSA Antibodies in Idiopathic Inflammatory Myopathies." JCR: Journal of Clinical Rheumatology 29, no. 7 (2023): 347–53. http://dx.doi.org/10.1097/rhu.0000000000002015.

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Background/Purpose Anti-Ro52 are myositis-associated antibodies found in idiopathic inflammatory myopathies (IIMs). This chart review aims to evaluate the frequency, significance, and associated clinical characteristics of Ro52/SSA positivity in IIM patients. Methods We performed a chart review of IIM patients diagnosed between January 2006 and December 2020. All patients met either the 1975 Bohan and Peter or the European League Against Rheumatism/American College of Rheumatology classification criteria for probable or definite myositis. Demographics, clinical and serologic parameters, treatm

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14

Emad, Y., T. Gheita, H. Darweesh, et al. "Antibodies to extractable nuclear antigens (ENAS) in systemic lupus erythematosus patients: correlations with clinical manifestations and disease activity." Reumatismo 70, no. 2 (2018): 85. http://dx.doi.org/10.4081/reumatismo.2018.1027.

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The aim was to explore possible correlations of antibodies to extractable nuclear antigens (ENA) with clinical manifestations and disease activity indices in systemic lupus erythematosus (SLE) patients. A total of 70 consecutive SLE patients (64 females) were included. Disease activity was assessed by SLE activity index (SLEDAI), and British Isles Lupus Assessment Group (BILAG). Anti-Ro/SSA correlated positively with, headache (r=0.24, p=0.04), blurring of vision (r=0.25, p=0.03) and SLEDAI (r=0.25, p=0.04) and negatively with C3 (r=–0.35, p=0.003). Anti-Ro/SSA correlated with anti La/SSB anti

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15

Brucatoup, A., F. Franceschini, A. Doria, et al. "Pathogenetic associations of maternal Anti-Ro/SSA antibodies." Lupus 11, no. 10 (2002): 650. http://dx.doi.org/10.1191/0961203302lu270oa.

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16

van der Molen, Renate G., Dörte Hamann, Joannes F. M. Jacobs, et al. "Anti-SSA antibodies are present in immunoglobulin preparations." Transfusion 55, no. 4 (2014): 832–37. http://dx.doi.org/10.1111/trf.12922.

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17

Butryn, Michaela, Jens Neumann, Leoni Rolfes, et al. "Clinical, Radiological, and Laboratory Features of Spinal Cord Involvement in Primary Sjögren’s Syndrome." Journal of Clinical Medicine 9, no. 5 (2020): 1482. http://dx.doi.org/10.3390/jcm9051482.

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Objective: To identify radiological and laboratory hallmarks in patients with primary Sjögren’s syndrome (pSS) presenting with spinal cord involvement. Methods: Clinical and laboratory routine parameters were analyzed in a retrospective multicenter case series of four patients who developed myelitis associated with pSS. Serological and cerebrospinal fluid (CSF) measurements of pSS associated anti-SSA(Ro)-antibodies were initiated, and CSF neurofilament light chain (NFL) levels were assessed. NFL values were compared with results from 15 sex- and age-matched healthy controls. Radiological asses

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18

Bellajdel, Ibtissam, Hind Bouyabla, Benhamou Imane, Hafsa Taheri, Hanane Saadi, and Ahmed Mimouni. "ANTENATAL DIAGNOSIS OF FETAL HEART RHYTHM DISORDERS IN WOMEN WITH LUPUS WITH POSITIVE ANTI-SSA AND ANTI-SSB ANTIBODIES: ABOUT TWO CASES." International Journal of Advanced Research 11, no. 03 (2023): 191–94. http://dx.doi.org/10.21474/ijar01/16406.

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Lupus erythematosus is a nonorgan-specific autoimmune disease predominantly affecting young women of childbearing age, as well as neonatal lupus is a complication related to the presence of anti-SSA/Ro or anti-SSb/La antibodies in the mother. Cardiac manifestations of neonatal lupus include anti-SSA/Ro-SSB/La-mediated conduction system disease and endocardial/myocardial damage resulting in cardiomyopathy. Pregnancy is a complicating factor in lupus erythematosus in 60% of cases. These complications do not seem to be related to the number of pregnancies or to the duration of remission, but stop

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19

Zurgil, N., R. Bakimer, A. Tincani, et al. "Detection of Anti-Phospholipid and Anti-DNA Antibodies and their Idiotypes in Newborns of Mothers with Anti-Phospholipid Syndrome and Sle." Lupus 2, no. 1_suppl (1993): 233–37. http://dx.doi.org/10.1177/0961203393002001091.

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The titers, isotypes and idiotypes of antiphospholipid and anti-dsDNA antibodies were determined in seven pairs of mothers with antiphospholipid syndrome (APLS) and their offspring, in 11 pairs of SLE mothers and their matched infants and in seven respective pairs of healthy subjects. In addition, maternal as well as fetal sera were evaluated for the presence of anti-SSA (Ro), anti-SSB (La) and anti-70 kd RNP autoantibodies. In the sera from APLS patients, as well as in the sera from their offspring, the mean antibody titer of IgG aCL was found to be significantly higher then the corresponding

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20

Kiss, M., S. Husz, and A. Dobozy. "The occurrence of antinuclear, anti-SSA/Ro and anti-SSB/La antibodies in patients with polymorphous light eruption." Acta Dermato-Venereologica 71, no. 4 (1991): 341–43. http://dx.doi.org/10.2340/0001555571341343.

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Serological features were investigated in 22 patients with polymorphous light eruption. The diagnosis was made from the history and clinical patterns and confirmed by phototesting and histological examinations. In 4 patients with polymorphous light eruption, anti-RNP antibodies were detected in the serum despite the fact that the antinuclear antibody tests were negative in all cases. The serum levels of anti-SSA/Ro antibodies in the patients were mildly but significantly elevated (p less than 0.001) as compared with healthy controls. No difference was found between the patients and controls re

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Yokochi, R., H. Tamai, T. Kido, et al. "POS0455 EFFECT OF ANTI-Ro/SSA ANTIBODIES FOR TREATMENT RESPONSE TO METHOTREXATE IN RHEUMATOID ARTHRITIS: A RETROSPECTIVE MULTICENTER OBSERVATIONAL STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 458.1–458. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1485.

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Background:Several previous observational studies have suggested that patients with anti-Ro/SSA antibody-positive rheumatoid arthritis (RA) may respond poorly to treatment, including tumor necrosis factor inhibitors1. However, its influence on methotrexate (MTX) treatment, which is the anchor drug of treat-to-target strategy in RA treatment, remains unclear.Objectives:We compared the clinical response to MTX in both anti-Ro/SSA antibody-positive and -negative patients with MTX-naiive RA and investigated the reasons for the difference in response.Methods:We recruited 210 consecutive patients wi

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Caraba, Alexandru, Stela Iurciuc, Mihaela Nicolin, and Mircea Iurciuc. "Endothelial Dysfunction in Primary Sjögren’s Syndrome: Correlation with Serum Biomarkers of Disease Activity." International Journal of Molecular Sciences 24, no. 18 (2023): 13918. http://dx.doi.org/10.3390/ijms241813918.

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To assess the relationship between endothelial dysfunction and serum cytokines, anti-SSA and anti-SSB antibodies, beta-2 microglobulin levels, focus score and EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) in primary Sjögren’s syndrome (pSS) patients. The study included 90 patients with pSS and 45 healthy subjects, matched for age and gender, as controls. Serum beta-2 microglobulin, total cholesterol, HDL-cholesterol, triglycerides, TNF-α, and IL-6 were analyzed in both the groups. Patients with pSS were also tested for antinuclear antibodies, anti-SAA (anti-Sjögren’s syndrome-relate

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Fredi, M., S. Bertocchi, E. Pedretti, et al. "POS1490 ANTI-RO/SSA-ANTIBODIES AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN PATIENTS WITH SYSTEMIC LUPUS ERYHEMATOSUS (SLE): DATA OF A MULTIDISCIPLINARY STUDY IN A MONOCENTRIC COHORT." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1101.2–1102. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1309.

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BackgroundCardiovascular involvement is common in patients with SLE and heart rhythm disorders are frequent in addition to the manifestations included in the classification criteria ACR/EULAR 2019. Previous studies provided evidence that anti-Ro/SSA-positivity is an independent risk factor for marked QTc prolongation; suggesting that subjects who are anti-Ro/SSA-positive may represent a subgroup with an increased predisposition to ventricular arrhythmias, particularly when other QT-prolonging risk factors are concomitantly present [1].ObjectivesThe aim of this study is to estimate the prevalen

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Smeele, Hieronymus T. W., Marco W. J. Schreurs, Nathalie Costedoat-Chalumeau, Jerome M. J. Cornette, and Radboud J. E. M. Dolhain. "Low prevalence of anti-SSA (anti-Ro) and anti-SSB (anti-La) autoantibodies in female patients with rheumatoid arthritis with a wish to conceive." RMD Open 7, no. 2 (2021): e001727. http://dx.doi.org/10.1136/rmdopen-2021-001727.

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ObjectivesGuidelines advise to test for anti–Sjögren's-syndrome-related antigen A (anti-SSA) and anti–Sjögren's-syndrome-related antigen B (anti-SSB) antibodies in all patients with rheumatoid arthritis (RA) who wish to conceive. Our objective was to determine the prevalence and titres of anti-SSA and anti-SSB autoantibodies in patients with RA with a wish to conceive or pregnant.MethodsPatients were derived from two large cohorts on RA and pregnancy (PARA cohort and PreCARA cohort). In addition, to determine the clinical relevance of searching for anti-SSA and anti-SSB in patients with RA, we

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Waki, Daisuke, Hiroya Tamai, Ritsuko Yokochi, et al. "Effects of anti-SSA antibodies on the response to methotrexate in rheumatoid arthritis: A retrospective multicenter observational study." PLOS ONE 17, no. 7 (2022): e0271921. http://dx.doi.org/10.1371/journal.pone.0271921.

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Comparison of clinical response to methotrexate between anti-SSA antibody-positive and -negative patients with methotrexate-naïve rheumatoid arthritis and investigate the reasons for the differences in the response. For this multicenter retrospective cohort study, a total of 210 consecutive patients with rheumatoid arthritis who newly initiated methotrexate were recruited. The effects of anti-SSA antibody positivity on achieving a low disease activity according to the 28-joint Disease Activity Score based on C-reactive protein after 6 months of methotrexate administration were investigated usi

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Singsen, Bernhard H., Jeanette E. Akhter, Mary M. Weinstein, and Gordon C. Sharp. "Congenital complete heart block and SSA antibodies: Obstetric implications." American Journal of Obstetrics and Gynecology 152, no. 6 (1985): 655–58. http://dx.doi.org/10.1016/s0002-9378(85)80039-9.

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Yoshida, Shunji, and Morris Reichlin. "A radioimmunoassay for antibodies to the Ro/SSA particle." Journal of Immunological Methods 131, no. 1 (1990): 113–18. http://dx.doi.org/10.1016/0022-1759(90)90240-v.

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Moutsopoulos, H. M., and L. V. Zerva. "Anti-Ro (SSA)/La (SSB) antibodies and Sjögren's syndrome." Clinical Rheumatology 9, S1 (1990): 123–31. http://dx.doi.org/10.1007/bf02205560.

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Bizzaro, Nicola, Fabrizio Bonelli, Elio Tonutti, Renato Tozzoli, and Danilo Villalta. "New Coupled-Particle Light-Scattering Assay for Detection of Ro/SSA (52 and 60 Kilodaltons) and La/SSB Autoantibodies in Connective Tissue Diseases." Clinical Diagnostic Laboratory Immunology 8, no. 5 (2001): 922–25. http://dx.doi.org/10.1128/cdli.8.5.922-925.2001.

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ABSTRACT The diagnostic and analytical performance of the coupled-particle light-scattering assay in detecting anti-Ro/SSA autoantibodies (the 60-kDa [Ro60] and the 52-kDa [Ro52] antibodies) and anti-La/SSB autoantibodies was evaluated. The antigens were obtained by recombinant DNA procedures to include the most immunogenic epitopes for each protein by using a prokaryotic expression system. Serum samples from 151 patients with connective tissue diseases and 52 control subjects (including patients with viral infections, patients with Lyme disease, and healthy subjects) were studied. Sensitiviti

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MOHAMMED, KHULOOD, JANET POPE, NICOLE LE RICHE, et al. "Association of Severe Inflammatory Polyarthritis in Primary Sjögren’s Syndrome: Clinical, Serologic, and HLA Analysis." Journal of Rheumatology 36, no. 9 (2009): 1937–42. http://dx.doi.org/10.3899/jrheum.080234.

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Objective.To evaluate the clinical, serologic, and MHC class II antigen characteristics of a group of patients with primary Sjögren’s syndrome (SS) and severe arthritis.Methods.A case-control study comparing 35 patients with primary SS: 17 with inflammatory arthritis, 18 without arthritis.Results.All patients fulfilled criteria for primary SS. There were no demographic or clinical features other than inflammatory arthritis, often erosive, that distinguished patients with arthritis from those without. All patients had anti-Ro/SSA autoantibodies, most had anti-La/SSB autoantibodies, and a high p

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Al-Mudhaffar, Mohassad H., and Taghreed F. Zaidan. "Evaluation of Anti-Centromere Antibodies, Anti-SSA and Anti-SSB in Serum and Saliva of Patients with Systemic Sclerosis." Journal of Baghdad College of Dentistry 30, no. 3 (2018): 17–20. http://dx.doi.org/10.26477/jbcd.v30i3.2526.

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Background: Systemic sclerosis (SSc) is a chronic autoimmune illness, which is consider by three main features: Sclerotic changes in the skin and internal organs, Vasculopathy of small blood vessels, Particular autoantibodies (1). The most important autoantibodies appeared significantly in SSc patients are anti-topoisomerase I autoantibody (Scl-70), anti-centromere autoantibody (ACA), and anti-RNA polymerase III autoantibody (RNAP3) (2). Anti-centromere antibodies (ACA) are infrequent in rheumatic conditions and in healthy persons but occur commonly in limited systemic sclerosis (CREST syndrom

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Menéndez, Aurora, Jesús Gómez, Luis Caminal-Montero, José Bernardino Díaz-López, Iván Cabezas-Rodríguez, and Lourdes Mozo. "Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus." Scientific World Journal 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/832789.

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Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P=0.024andP=0.019, resp.) and anti-Ro52/TRIM21 (P=0.026andP=0.022, resp.). In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P=0.014) tha

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Scharpe, S., W. Uyttenbroeck, and W. Cooreman. "The Presence of Antibodies against Extractable Nuclear Antigens in Serum: A Comparison of Immunoblotting versus Radial Immunodiffusion." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 30, no. 1 (1993): 83–86. http://dx.doi.org/10.1177/000456329303000114.

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A commercial immunoblotting kit has recently been introduced to determine auto-antibodies against extractable nuclear antigens. We compared this new test with radial immunodiffusion for its usefulness in the routine laboratory procedures of a general hospital. Antigen preparation in immunoblotting includes a protein denaturation step prior to electrophoretic separation of the different proteins. In this way antigenic determinants that depend heavily on the protein superstructure are lost. In theory, auto-antibodies against these epitopes may be missed. In our series of 100 samples that had tes

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Fantò, M., S. Salemi, F. Socciarelli, et al. "A Case of Subacute Cutaneous Lupus Erythematosus in a Patient with Mixed Connective Tissue Disease: Successful Treatment with Plasmapheresis and Rituximab." Case Reports in Rheumatology 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/857694.

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A 30-year-old woman affected by Mixed Connective Tissue Disease with scleroderma spectrum developed a facial eruption, a clinical and histological characteristic of subacute cutaneous lupus erythematosus (SCLE). Speckled anti-nuclear antibodies, high-titer anti-ribonucleoprotein1, anti-Sm, anti-Cardiolipin (aCL) IgG/IgM, and anti-Ro/SSA antibodies were positive. SCLE was resistant to Azathioprine, Hydroxychloroquine, and Methotrexate while Mycophenolate Mofetil was suspended due to side effects. Subsequently, the patient was treated with three cycles of therapeutic plasma exchange (TPE) follow

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Yang, L. J., H. G. Li, A. Q. Zeng, et al. "AB0296 PASSIVE TRANSFER OF ANTI-SSA, ANTI-Ro52, AND ANTI-MITOCHONDRIAL M2 FROM INTRAVENOUS IMMUNOGLOBULIN PRODUCTS TO PATIENTS WITH RHEUMATIC DISEASES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1174.2–1174. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3544.

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Background:Passive transfer of ANA and anti-SSA has been reported in patients with common variable immunodeficiency disorder who received intravenous immunoglobulin (IVIG). IVIG is also recommended to treat some special or life-threatening rheumatic diseases.Objectives:This study was aimed to explore whether any extractable nuclear antibodies (ENAs) were transferred to these rheumatic patients who received IVIG therapy.Methods:IVIG products of three batches were tested for ANA by using indirect immunofluorescent assay, and for ENAs by using line immunoassay (LIA) and chemiluminescence immunoas

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Takeshita, Masaru, Katsuya Suzuki, Yukari Kaneda, et al. "Antigen-driven selection of antibodies against SSA, SSB and the centromere ‘complex’, including a novel antigen, MIS12 complex, in human salivary glands." Annals of the Rheumatic Diseases 79, no. 1 (2019): 150–58. http://dx.doi.org/10.1136/annrheumdis-2019-215862.

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ObjectivesRecent evidences have revealed that anti-SSA/SSB antibodies, the major autoantibodies in Sjögren's syndrome (SS), are produced in salivary glands. This study aims to clarify overall of autoantibody production at lesion site, including anti-centromere antibody (ACA)-positive SS.MethodsAntibodies of antibody-secreting cells in human salivary glands were produced as recombinant antibodies. The reactivity of these antibodies and their revertants were investigated by ELISA and newly developed antigen-binding beads assay, which can detect conformational epitopes. The target of uncharacteri

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Van den Bergh, Karolien, Herbert Hooijkaas, Daniel Blockmans, et al. "Heterogeneous Nuclear Ribonucleoprotein H1, a Novel Nuclear Autoantigen." Clinical Chemistry 55, no. 5 (2009): 946–54. http://dx.doi.org/10.1373/clinchem.2008.115626.

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Abstract Background: Serum samples from patients with autoimmune connective tissue diseases that show a finely speckled antinuclear antibody (ANA) on indirect immune-fluorescence often have antibodies against unknown nuclear target antigens. To search for such autoantigens we applied a proteomic approach using sera from patients with a high ANA titer (≥640) and finely speckled fluorescence but in whom no antibodies to extractable nuclear antigens (ENA) could be identified. Methods: Using an immunoproteomics approach we identified heterogeneous nuclear ribonucleoprotein H1 (hnRNP H1) as a novel

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Abu-Hishmeh, Mohammad, Alamgir Sattar, Z. Zarlasht, et al. "Rare Case of Lupus Nephritis With Negative Antinuclear Antibodies, Double-Stranded DNA Antibodies and Positive Anti-Ro/SSA Antibodies." World Journal of Nephrology and Urology 5, no. 2 (2016): 48–49. http://dx.doi.org/10.14740/wjnu272e.

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Adelowo, Olufemi O., Kenneth A. Ohagwu, Ejiehi E. Aigbokhan, and Richard O. Akintayo. "The Child as a Surrogate for Diagnosis of Lupus in the Mother." Case Reports in Rheumatology 2017 (2017): 1–2. http://dx.doi.org/10.1155/2017/8247591.

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Introduction. Neonatal lupus erythematosus (NLE) is an acquired disease of the newborn caused by transplacental transfer of maternal anti-Ro/SSA, anti-La/SSB, and infrequently anti-U1 RNP antibodies. Methodology. This is a case report of a male infant delivered via Caesarean section at 36-week gestation following detection of fetal bradycardia during routine antenatal clinic visit. Results. The mother was seropositive for antinuclear antibody (ANA) and anti-Ro/SSA and had elevated erythrocyte sedimentation rate. The baby was positive for ANA, extractable nuclear antigen (ENA), and anti-Ro/SSA.

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Elnady, B., M. M. Alqarni, M. A. Mostafa, and E. S. Fouda. "Right ventricular thrombus in a case of neonatal lupus: case report." Lupus 28, no. 6 (2019): 783–85. http://dx.doi.org/10.1177/0961203319846384.

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Neonatal thrombosis is considered a rare manifestation with unclear aetiology. We reported a neonatal lupus of a Sjogren’s syndrome mother with recurrent miscarriage secondary to antiphospholipid syndrome; seronegative to anticardiolipin antibodies, lupus anticoagulant and B2GP1. She was serologically positive to antiphosphatidylethanolamine and antiprothrombin antibodies, anti-SSA/Ro and anti-SSB/La. The neonate developed neonatal lupus complicated with right ventricular thrombus assumed to be induced by maternal transmission of antiphosphatidylethanolamine and antiprothrombin antibodies, tre

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Mossel, Esther, Konstantina Delli, Jolien F. van Nimwegen, et al. "Ultrasonography of major salivary glands compared with parotid and labial gland biopsy and classification criteria in patients with clinically suspected primary Sjögren’s syndrome." Annals of the Rheumatic Diseases 76, no. 11 (2017): 1883–89. http://dx.doi.org/10.1136/annrheumdis-2017-211250.

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ObjectiveTo assess the validity of ultrasound of major salivary glands (sUS) compared with parotid and labial gland biopsies, sialometry, anti-SSA/Ro antibody status and classification criteria in patients clinically suspected with primary Sjögren’s syndrome (pSS).Methods103 consecutive outpatients with clinically suspected pSS underwent sUS. Parenchymal echogenicity, homogeneity, hypoechogenic areas, hyperechogenic reflections and clearness of salivary gland border were scored according to the Hocevar scoring system. Total ultrasound score was calculated as the sum of these domains (range 0–4

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Burek, C. Lynne, Monica V. Talor, Rajni B. Sharma, and Noel R. Rose. "The NOD.H2h4 mouse shows characteristics of human Sjogren’s Syndrome (130.26)." Journal of Immunology 178, no. 1_Supplement (2007): S232—S233. http://dx.doi.org/10.4049/jimmunol.178.supp.130.26.

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Abstract The objective of this study was to identify critical features of the NOD.H2h4 mouse as an appropriate model to study the pathogenesis of human Sjögren’s Syndrome. Salivary and lacrimal glands of male or female mice at different age groups were examined histologically for cellular infiltration. Sera were examined for ANA by indirect immunofluorescence on Hep2 slides and for SSA/Ro and SSB/La antibodies by ELISA. Salivary function was evaluated by measuring saliva volume following pilocarpine stimulation. At 20–24 weeks, female mice showed more frequent salivary gland infiltration than

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Franceschini, F., P. Calzavara-Pinton, M. Quinzanini, et al. "Chilblain lupus erythematosus is associated with antibodies to SSA/Ro." Lupus 8, no. 3 (1999): 215–19. http://dx.doi.org/10.1191/096120399678847632.

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Motta, M., C. Rodriguez-Perez, A. Tincani, A. Lojacono, and G. Chirico. "Outcome of infants from mothers with anti-SSA/Ro antibodies." Journal of Perinatology 27, no. 5 (2007): 278–83. http://dx.doi.org/10.1038/sj.jp.7211688.

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Miyagawa, Sachiko, Hiroshi Kato, Kazuhiro Dohi, et al. "Congenital cardiac defects associated with maternal anti-SSA/RO antibodies." American Journal of Medicine 85, no. 6 (1988): 888–90. http://dx.doi.org/10.1016/s0002-9343(88)80049-4.

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Franceschini, Franco, Pier G. Calzavara-Pinton, Laura Valsecchi, et al. "Chilblain lupus erythematosus is associated with antibodies to SSA/Ro." Journal of Dermatological Science 16 (March 1998): S174. http://dx.doi.org/10.1016/s0923-1811(98)84039-5.

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Moeller, Jeremy J., Daniel Friedman, Patricia Dugan, and Cigdem I. Akman. "Refractory Status Epilepticus Associated with Anti-SSA (anti-Ro) Antibodies." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 39, no. 5 (2012): 660–63. http://dx.doi.org/10.1017/s0317167100015444.

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Chen, Pei-Hsuan, Yao-Hsu Yang, Yu-Tsan Lin, et al. "Clinical characteristics of children with positive anti-SSA/SSB antibodies." Rheumatology International 34, no. 8 (2013): 1123–27. http://dx.doi.org/10.1007/s00296-013-2870-5.

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Caraiola, Simona, Laura Voicu, Daniela Opriș-Belinski, et al. "The Role of Anti-SSB/La Antibodies as Predictors of Decreased Diffusing Capacity of the Lungs for Carbon Monoxide (DLCO) in Primary Sjögren Disease." International Journal of Molecular Sciences 26, no. 12 (2025): 5867. https://doi.org/10.3390/ijms26125867.

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Lung involvement is the most common extraglandular manifestation of primary Sjögren’s Disease (pSjD). There is an increasing interest in finding the clinical/serological risk predictors of this feature. A cross-sectional study evaluating anti-SSA/Ro antibodies, anti-SSB/La antibodies, rheumatoid factor, antinuclear antibodies, and the diffusing capacity of the lungs for carbon monoxide (DLCO) in 26 pSjD patients who presented interstitial changes on the chest CT scan was performed. The titres and positivity rates for anti-SSA/Ro (p = 0.02, p = 0.02) and anti-SSB/La antibodies (p = 0.01, p = 0.

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Murng, Sai H. K., and Moira Thomas. "Clinical associations of the positive anti Ro52 without Ro60 autoantibodies: undifferentiated connective tissue diseases." Journal of Clinical Pathology 71, no. 1 (2017): 12–19. http://dx.doi.org/10.1136/jclinpath-2015-203587.

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AimsAutoantibodies targeting Ro52 and Ro60 antigens are historically reported as anti SSA/Ro. In general anti SSA/Ro results are either anti Ro52+Ro60+ or anti Ro52−Ro60+ antibodies. Anti Ro52 without anti Ro60 (Ro52+ Ro60−) antibodies are often not reported routinely. This study intends to review the potential significance of these autoantibodies in the management of connective tissue diseases.MethodA retrospective survey of Ro52+Ro60− was carried out as part of the service evaluation of extractable nuclear antigen antibodies (ENA) reporting from the immunology laboratory, the NHS Greater Gla

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