Academic literature on the topic 'SSR180575'

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Journal articles on the topic "SSR180575"

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Damont, Annelaure, Frank Marguet, Frédéric Puech, and Frédéric Dollé. "Synthesis and in vitro characterization of novel fluorinated derivatives of the TSPO 18 kDa ligand SSR180575." Eur J Med Chem. 101 (August 28, 2015): 736–45. https://doi.org/10.1016/j.ejmech.2015.07.033.

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SSR180575 (1) is a high-affinity (0.83 nM) TSPO 18 kDa ligand belonging to the pyridazino[4,5-b]indole-1-acetamides family. Herein we describe the synthesis and in vitro characterization of two series of new fluorinated analogues. Eleven compounds (out of fifteen) displayed nanomolar to subnamolar affinities (0.30-8.1 nM) and high selectivities (Ki(CBR)/Ki(TSPO) > 10(3)). Two derivatives stand out as promising candidates for drug development or use as PET probes for in vivo neuroinflammation imaging, once fluorine-18-labelled.
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Vin, V., N. Leducq, F. Bono, and J. M. Herbert. "Binding characteristics of SSR180575, a potent and selective peripheral benzodiazepine ligand." Biochemical and Biophysical Research Communications 310, no. 3 (2003): 785–90. http://dx.doi.org/10.1016/j.bbrc.2003.09.079.

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Damont, Annelaure, Frank Marguet, Frédéric Puech, and Frédéric Dollé. "Synthesis and in vitro characterization of novel fluorinated derivatives of the TSPO 18 kDa ligand SSR180575." European Journal of Medicinal Chemistry 101 (August 2015): 736–45. http://dx.doi.org/10.1016/j.ejmech.2015.07.033.

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Leducq-Alet, N., V. Vin, P. Savi, and F. Bono. "TNF-alpha induced PMN apoptosis in whole human blood: Protective effect of SSR180575, a potent and selective peripheral benzodiazepine ligand." Biochemical and Biophysical Research Communications 399, no. 4 (2010): 475–79. http://dx.doi.org/10.1016/j.bbrc.2010.07.011.

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Nicolas, Irène, Christian Bijani, Denis Brasseur, Geneviève Pratviel, Jean Bernadou, and Anne Robert. "Metalloporphyrin-catalyzed hydroxylation of the N,N-dimethylamide function of the drug molecule SSR180575 to a stable N-methyl-N-carbinolamide." Comptes Rendus Chimie 16, no. 11 (2013): 1002–7. http://dx.doi.org/10.1016/j.crci.2013.05.001.

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Leducq-Alet, Nathalie, Valerie Vin, Pierre Savi та Françoise Bono. "Protective effect of SSR180575, a potent and selective peripheral benzodiazepine ligand, on TNF-α induced PMN apoptosis in whole human blood". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797 (липень 2010): 122–23. http://dx.doi.org/10.1016/j.bbabio.2010.04.366.

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Chauveau, Fabien, Hervé Boutin, Nadja Van Camp, et al. "In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa)." European Journal of Nuclear Medicine and Molecular Imaging 38, no. 3 (2010): 509–14. http://dx.doi.org/10.1007/s00259-010-1628-5.

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Ferzaz, Badia, Emmanuel Brault, Genevieve Bourliaud, et al. "SSR180575 (7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a Peripheral Benzodiazepine Receptor Ligand, Promotes Neuronal Survival and Repair." Journal of Pharmacology and Experimental Therapeutics 301, no. 3 (2002): 1067–78. http://dx.doi.org/10.1124/jpet.301.3.1067.

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Thominiaux, Cyrille, Annelaure Damont, Bertrand Kuhnast, et al. "Radiosynthesis of 7-chloro-N,N-dimethyl-5-[11C]methyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, [11C]SSR180575, a novel radioligand for imaging the TSPO (peripheral benzodiazepine receptor) with PET." Journal of Labelled Compounds and Radiopharmaceuticals 53, no. 13 (2010): 767–73. http://dx.doi.org/10.1002/jlcr.1794.

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Cheung, Yiu-Yin, Michael L. Nickels, Dewei Tang, Jason R. Buck, and H. Charles Manning. "Facile synthesis of SSR180575 and discovery of 7-chloro- N , N ,5-trimethyl-4-oxo-3(6-[ 18 F]fluoropyridin-2-yl)-3,5-dihydro-4 H -pyridazino[4,5- b ]indole-1-acetamide, a potent pyridazinoindole ligand for PET imaging of TSPO in cancer." Bioorganic & Medicinal Chemistry Letters 24, no. 18 (2014): 4466–71. http://dx.doi.org/10.1016/j.bmcl.2014.07.091.

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Dissertations / Theses on the topic "SSR180575"

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Geremias, Denise de Souza. "Avaliação da atividade antiinflamatória do SSR180575, um ligante do receptor benzodiazepínico periférico, no modelo da pleurisia induzida pela carragenina, em camundongos." Florianópolis, SC, 2004. http://repositorio.ufsc.br/xmlui/handle/123456789/86977.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.<br>Made available in DSpace on 2012-10-21T13:02:25Z (GMT). No. of bitstreams: 0Bitstream added on 2013-07-16T19:38:18Z : No. of bitstreams: 1 205880.pdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Introdução: O modelo da pleurisia induzido pela carragenina é caracterizado por um aumento significante da exudação e da migração celular, às custas de neutrófilos 4 h depois de indução de pleurisia. Esta fase é nomeada de fase recente. A fase tardia o
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