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Journal articles on the topic 'St. Alexius'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Halka, Joshua T., Danielle Yee, Andrew Angus, Azmath Mohammed, Shruti Sevak, and James Robbins. "Alexis St. Martin Gastropexy." Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 29, no. 2 (2019): e20-e23. http://dx.doi.org/10.1097/sle.0000000000000616.

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2

Kessel, R. W. I. "Osler, Beaumont and Alexis St Martin." Journal of the Royal Society of Medicine 84, no. 4 (1991): 245. http://dx.doi.org/10.1177/014107689108400426.

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3

Leme, Pedro Luiz Squilacci. "Alexis St. Martin – the intrepid guinea pig?" Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo 63, no. 2 (2018): 139. http://dx.doi.org/10.26432/1809-3019.2018.63.2.139.

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O objetivo deste texto é apresentar o recorte histórico de um fato pouco conhecido e não explorado por nossa literatura médica, assim como discutir críticas recentes e pouco fundamentadas nos relatos históricos à conduta médica e ética envolvidas, que utilizaram um enfoque do século XXI a fatos ocorridos no século XIX.

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4

Medvedev, A. "Oral legends about St. Alexis of Moscow." Русская речь, no. 5 (2018): 99–104. http://dx.doi.org/10.31857/s013161170001626-7.

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5

Sarr, Michael G., Paul Bass, and Edward Woodward. "The famous gastrocutaneous fistula of Alexis st. Martin." Digestive Diseases and Sciences 36, no. 10 (1991): 1345–47. http://dx.doi.org/10.1007/bf01296797.

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6

Roland, Charles G. "Alexis St. Martin and His Relationship with William Beaumont." Bulletin of Anesthesia History 17, no. 2 (1999): 9–18. http://dx.doi.org/10.1016/s1522-8649(99)50017-6.

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7

Myers, N. A., and E. Durham Smith. "A DEBT TO ALEXIS: THE BEAUMONT-ST MARTIN STORY." ANZ Journal of Surgery 67, no. 8 (1997): 534–39. http://dx.doi.org/10.1111/j.1445-2197.1997.tb02033.x.

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8

Pinder, Janice M. "The Intertextuality of Old French Saints' Lives: St. Giles, St. Evroul and the Marriage of St. Alexis." Parergon 6, no. 2 (1988): 11–21. http://dx.doi.org/10.1353/pgn.1988.0020.

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9

Pirivatric, Srdjan. "The Greek emperor Alexios in the first vitae of St Simeon Nemanja." Zbornik radova Vizantoloskog instituta, no. 53 (2016): 161–78. http://dx.doi.org/10.2298/zrvi1653161p.

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In the wider context of references to the "Greek" i.e. Byzantine Emperors in the first saints? lives of the Nemanjic dynasty, we turn our attention here to the nature and historical background of references to the Byzantine Emperor Alexios III Angelos in the founder?s Vita of the Venerable Simeon Nemanja by St Sava (written as a prologue of the Typikon for Studenica monastery), and the reasons for the omission of any such reference from the Vita of St Simeon Nemanja written by Stefan the First Crowned, both viewed in the context of the impact of current political circumstances on the historiog

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10

Gerry, Kathryn. "The Alexis Quire and the cult of saints at St. Albans*." Historical Research 82, no. 218 (2009): 593–612. http://dx.doi.org/10.1111/j.1468-2281.2008.00475.x.

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11

Pigin, Alexander V. "On Some Sources of the Life of Alexander Oshevensky (The Theme of the Family in the Hagiography)." Scrinium 11, no. 1 (2015): 281–94. http://dx.doi.org/10.1163/18177565-00111p23.

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(1567) is a Northern Russian hagiographical work devoted to the founder of the St. Niсholas Alexander-Oshevensky Monastery, which was located nearby the town of Kargopol. The article analyses hagiographer Theodosius’ techniques for dealing with literary sources, especially with two Byzantine texts, The Ladder by John Climacus and The Life of Alexis the Man of God. Theodosius uses these sources to develop one of the major themes of his own work, that is, the relationship between St. Alexander and his family. The family theme bears ambiguous meaning. On the one hand, the family is rejected from

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12

Crostini, Barbara. "Mapping Miracles in Byzantine Hagiography: The Development of the Legend of St Alexios." Studies in Church History 41 (2005): 77–87. http://dx.doi.org/10.1017/s0424208400000139.

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Hagiographical narrative is often examined through the well-established text-critical principle according to which the earliest text is necessarily the most skeletal in outline, the least wondrous in plot, and therefore the most historically believable. According to this view, to the bare bones of truth, fanciful narrative and miraculous tales are added with time, as the tale grows in the telling. The development of the Legend of St Alexios has been viewed as a case in point. The idiosyncratic life-story of this fourth-century ascete has been described as evolving from a nucleus of ‘fact’, ess

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13

Alexa Green. "Working Ethics: William Beaumont, Alexis St. Martin, and Medical Research in Antebellum America." Bulletin of the History of Medicine 84, no. 2 (2010): 193–216. http://dx.doi.org/10.1353/bhm.0.0341.

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14

Vinogradov, Andrey Yu, and Victor N. Chkhaidze. "Theodore Gabras and His Seals." Античная древность и средние века 48 (2020): 254–69. http://dx.doi.org/10.15826/adsv.2020.48.016.

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This publication examines the life of Theodore Gabras, one of the highest Byzantine dignitaries in the 1080–1090s. The early stage of his career is uncovered by a miniature from a manuscript residing in St. Petersburg which depicts a scene with ktetores, patrikios, and topoteretes Theodore Gabras and his wife Irene. The similarity of this miniature and an eleventh-century fresco in the Senty Church in Alania (modern Karachay-Cherkessia) indicates that Irene was probably of Alanic origin like his second wife. The account of Theodore Gabras appeared in Anna Komnene’s Alexiad and John Zonaras’ ch

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15

Medvedev, Alexander A. "INVENTION AND DOUBLE TRANSLATION OF THE RELICS IN THE LIFE OF MOSCOW METROPOLITAN ALEXIS OF THE 17TH СENTURY". Vestnik slavianskikh kul’tur [Bulletin of Slavic Cultures] 58 (2020): 165–70. http://dx.doi.org/10.37816/2073-9567-2020-58-165-170.

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We find the story of the invention and double translation of the relics of Moscow Metropolitan Alexis included in the 17th century “The Lay of the Life in the Saints of our Father Alexis, Metropolitan of Kiev and All Russia, Wonderworker”, located in the Synodal Collection No. 596 of the State Historical Museum. Euthymius of Chudovsky, compiler of the fifth edition of the life, the cellarer of the Chudovsky monastery uses, when creating a new edition of the life of St. Alexis, all sources available to him: the life written by Pachomius Logothetes, literary monuments about Alexis as part of the

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16

Richardson, K. C., and M. C. Calver. "Beyond Alexis St Martin: contemporary techniques for studying the functioning of the gastrointestinal tract." Journal of Biological Education 25, no. 4 (1991): 308–13. http://dx.doi.org/10.1080/00219266.1991.9655230.

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17

ΛΑΜΠΑΚΗΣ, Στέλιος. "Μακεδονικὴ δυναστεία καὶ Μεγαλοκομνηνοί. Σχόλια σχετικὰ μὲ τὰ ἱστορικὰ στοιχεῖα στὰ «Θαύματα τοῦ Ἁγίου Εὐγενίου» τοῦ Ἰωάννη-Ἰωσὴφ Λαζαρόπουλου". BYZANTINA SYMMEIKTA 8 (29 вересня 1989): 319. http://dx.doi.org/10.12681/byzsym.729.

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<p> </p><p>S. Lampakis</p><p>La Dynastie Macédonienne et les Grands Comnènes de Trébizonde. Éléments historiques dans les «Miracles de St. Eugène» par Jean-Joseph Lazaropoulos </p><p>La Relation des Miracles de St. Eugène, écrite par Jean-Joseph Lazaropoulos, évêque de Trébizonde (1364-68), comprend un grand nombre d'éléments historiques sur les empereurs de la dynastie Macédonienne - surtout sur Basile II et les premières années difficiles de son règne, quand il devait faire face à plusieurs attentats d'usurpation. Comme il est démontré dans cette étu

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18

Dushenko, Constantine. "“St. Petersburg Flood Legend” and the Myth of the “End of Petersburg”." Philosophy. Journal of the Higher School of Economics V, no. 2 (2021): 34–54. http://dx.doi.org/10.17323/2587-8719-2021-2-34-54.

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The article examines the “flood legend” as part of the cultural myth of the “end of St. Petersburg” (ie, in essence, the end of the empire created by Peter I.). The existence of a “folklore flood legend” is postulated by all authors of works on the “Petersburg myth” and “Petersburg text”. It is believed that it is she who lies at the origins of literary works on this subject. In reality, the situation was the other way around: it was not a literary legend that arose from oral tradition, but the idea of “oral tradition” arose under the influence of an already existing literary legend. There is

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19

Ellis, Harold. "Alexis St. Martin, whose traumatic gastric fistula enabled William Beaumont to study the secretion of gastric juice in man." Journal of Perioperative Practice 31, no. 4 (2021): 163–64. http://dx.doi.org/10.1177/1750458920957248.

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20

Purciello, Maria Anne. "Early Modern Comedy and the Politics of Religion: Reconsidering Comedy in Rospigliosi's Il Sant'Alessio." Journal of the Royal Musical Association 143, no. 1 (2018): 51–87. http://dx.doi.org/10.1080/02690403.2018.1434341.

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ABSTRACTGiulio Rospigliosi and Stefano Landi's 1634 revisions of Il Sant'Alessio for the Barberini stage expanded the role of comedy within the opera. These revisions reveal an important juncture in the history of religious comedy and lay the foundation for the development of a comic rubric for the still-developing operatic genre. This article examines the legend of St Alexis and its potential for historic reinterpretation in light of the Barberini family's religious and political goals. Its consideration of the interrelationship of religion and comedy in early modern sacred drama provides the

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21

Galchenko, A. V., R. Ranjit, M. Yu Yakovlev, and V. A. Revyakina. "NUTRITION AND SOMATIC CONDITION OF THE STAFF OF THE HOSPITAL OF ST. ALEXIS DURING GREAT ORTHODOX LENT: A CROSS-SECTIONAL STUDY." Trace Elements in Medicine (Moscow) 21, no. 4 (2020): 40–52. http://dx.doi.org/10.19112/2413-6174-2020-21-4-40-52.

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Many people following different religions undergo fasting as their religious courtesy but the effects of being in a Lenten diet among Russians have not been fully studied yet. The research evaluates the ef-fect of fasting on nutritional status during Great Lent. Methodology. The study was performed among 44 people aged 23 to 65 years, including 9 men and 35 women. A physical examination was carried out and their complaints about well-being were noted carefully. The nutrient composition of the diet was determined by the method of frequency analysis of food consumption during the period of the G

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22

Mai, François M. "Beaumont's Contribution to Gastric Psychophysiology: A Reappraisal." Canadian Journal of Psychiatry 33, no. 7 (1988): 650–53. http://dx.doi.org/10.1177/070674378803300715.

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William Beaumont's monograph on the physiology of digestion which was first published in 1833, has become a classic in its field. In a series of experiments over a 10 year period on Alexis St. Martin, a 19 year old Canadian voyageur with a traumatic gastric fistula, Beaumont was the first to describe many important aspects of the digestive process. In two of the 238 experiments Beaumont noted gastric physiological changes induced by emotional arousal, these being bile reflux and delayed gastric emptying. Elsewhere in the book, but not in experimental context, Beaumont referred to non-specific

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23

Eissa, Hesham, Brandon M. Triplett, Mari H. Dallas, et al. "Transplant Outcome of Pediatric and Young Adult Patients with Aplastic Anemia: St Jude Children’s Research Hospital Experience." Blood 124, no. 21 (2014): 1210. http://dx.doi.org/10.1182/blood.v124.21.1210.1210.

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Abstract Background: Bone marrow transplant (BMT) remains the preferred frontline curative modality for patients with aplastic anemia in the presence of a matched sibling donor (MSD). In the absence of MSD the general consensus is frontline immunosuppressive therapy (IST) followed by BMT from a matched unrelated donor (MUD) in case of failure or relapse. No randomized controlled studies have been performed to compare earlier MUD transplant to 2nd cycle IST in case of failure of response to 1st IST cycle. In the pediatric population a higher percentage of congenital marrow failure syndromes is

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24

Kadura, P. "Mathematik für Chemiker: Von G. Alexits und St. Fenyö. Aus dem Ungarischen übersetzt von Prof. Dr. Stefan Fenyö. Gemeinschaftsausgabe der Akademischen Verlagsgesellschaft Geest & Portig K.-G., Leipzig, und des Akadémiai Kiadó, Budapest 1962. VIII, 449 Sei." Zeitschrift für Chemie 3, no. 5 (2010): 200. http://dx.doi.org/10.1002/zfch.19630030524.

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25

Pagliuca, Simona, Flore Sicre de Fontbrune, Serena Marotta, et al. "Aplastic Anemia in the Context of Hemolytic Paroxysmal Nocturnal Hemoglobinuria: Feasibility of Antibody-Based Intensive Immunosuppression during Eculizumab Treatment." Blood 128, no. 22 (2016): 5074. http://dx.doi.org/10.1182/blood.v128.22.5074.5074.

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Abstract Paroxysmal nocturnal hemoglobinuria (PNH) may present as hemolytic (classical PNH) or aplastic (AA/PNH syndrome) PNH. While classical PNH patients requires anti-complement treatment (eculizumab), the treatment of AA/PNH patients should target their bone marrow failure (BMF) by immunosuppression (IST), or even bone marrow transplantation (BMT). However, in a few patients clinically meaningful AA and hemolysis may be concomitant, eventually justifying both IST and eculizumab. To date there is no standard treatment for this rare condition. Here we investigated the prevalence of this cond

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Clarke, A. E., Y. St-Pierre, V. Paly, et al. "POS0734 EXTRAPOLATION OF LONG-TERM OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS: REPLICATING A HOPKINS LUPUS COHORT ANALYSIS WITH THE SYSTEMIC LUPUS INTERNATIONAL COLLABORATING CLINICS (SLICC) INCEPTION COHORT." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 617.2–618. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1790.

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Background:A disease model of systemic lupus erythematosus (SLE) that predicts short-term outcomes (disease activity and prednisone use) and links them to long-term outcomes (accrual of organ damage and mortality) was previously developed in a single center SLE cohort (Johns Hopkins [JH]) to support health economic analyses (Watson 2015), which has not been comprehensively replicated in other cohorts or contexts.Objectives:As part of an effort to develop and refine this existing disease model, the aim of this study was to replicate the previously estimated network of risk equations for short-

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Wan, Bo Angela, Richard A. Wells, Lisa Chodirker, et al. "Prognostic Performance of Frailty Measures in MDS Patients Treated with Hypomethylating Agents." Blood 134, Supplement_1 (2019): 4245. http://dx.doi.org/10.1182/blood-2019-128949.

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Background: Hypomethylating agents (HMAs) can confer transfusion independence and prolong overall survival (OS) in patients with myelodysplastic syndromes (MDS), but response rates are < 50% and depend on sustained administration. In Ontario, 33% of higher risk MDS patients receive < 4 cycles AZA and have very short survival. Identifying the patients unsuitable for HMAs and the factors predictive of overall survival (OS)/leukemia free survival (LFS) would be of value. MDS-CAN, the national MDS registry prospectively evaluates patient-related factors in addition to disease factors in MDS,

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Buckstein, Rena, Nancy Zhu, Mary-Margaret Keating, et al. "Persistent Red Blood Cell (RBC) Transfusion Is Associated with Increased Mortality Risk in Transfusion-Dependent (TD) Patients with Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS+)." Blood 134, Supplement_1 (2019): 3012. http://dx.doi.org/10.1182/blood-2019-123684.

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Introduction: Patients with lower-risk (LR) MDS, defined as very low-, low-, and intermediate-risk by the Revised International Prognostic Scoring System (IPSS-R), have a reduced risk of progressing to acute myeloid leukemia compared with higher-risk patients, but a shortened overall survival (OS) compared with age-matched controls. MDS patients with RS have a better prognosis than those without RS, but may experience extended periods of RBC transfusion dependence. RBC transfusion dependence is associated with reduced OS in patients with LR-MDS, but studies focusing on RBC transfusion dependen

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Buckstein, Rena, Richard A. Wells, Nancy Y. Zhu, et al. "Quality of Life Scores Improve with Increasing Hemoglobin but Optimal Thresholds Vary According to Transfusion Dependence and Clinical Risk Scores: A Canadian Cross Sectional Study of 689 Patients with 2969 Measurements." Blood 128, no. 22 (2016): 3192. http://dx.doi.org/10.1182/blood.v128.22.3192.3192.

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Abstract Background : We previously presented that selected quality of life (QOL) domains in MDS patients are impaired compared with age-matched controls and most impacted by hemoglobin (Hgb) level, transfusion dependence, frailty and comorbidity in an initial cohort of 236 patients from a Canadian MDS registry (Buckstein R. et al, Abstract 699, ASH 2012 and Abstract 2500, ASH 2009). The optimal Hgb threshold associated with improved QOL may vary according to health states that may fluctuate for any given patient. With longer follow up and greater sample size, we now examine the impact of Hgb

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30

Pavenski, Katerina, Megan Buchholz, and Michelle Sholzberg. "Diagnosis and Outcomes of Patients Presenting with Microangiopathic Hemolytic Anemia and Thrombocytopenia to a University Hospital Apheresis Unit." Blood 128, no. 22 (2016): 1366. http://dx.doi.org/10.1182/blood.v128.22.1366.1366.

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Abstract Background: A syndrome of MAHA, thrombocytopenia and microthrombosis (MAHATT) can result from a variety of etiologies. Making an accurate diagnosis is important to guide treatment decisions and to inform prognosis. Our centre is one of the two adult apheresis centres serving a catchment area of over 5 million people. Our centre maintains database of all patients who were referred for investigation and treatment of MAHATT. Materials and Methods: ADAMTS13 testing was performed at our centre by a qualitative collagen binding assay before 2011 and by ELISA (Technoclone GmbH, Viennna) afte

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Pavenski, Katerina, Christoph Licht, and Michael Kirschfink. "Utility of Complement and ADAMTS13 Testing in Diagnosis of Thrombotic Microangiopathy: A Single Centre Retrospective Review." Blood 124, no. 21 (2014): 2787. http://dx.doi.org/10.1182/blood.v124.21.2787.2787.

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Abstract Background: A syndrome of TMA presenting with MAHA and thrombocytopenia can result from a variety of etiologies. Making an accurate diagnosis is important to guide treatment decisions and to inform prognosis. Our centre is one of the two adult apheresis units in the Greater Toronto Area, Ontario, Canada with a catchment area of over 5 million people. Our centre maintains a database of all patients who were referred for investigation and treatment of TMA. We present our initial experience with complement testing (protein, function and genetics) in identifying patients with aHUS. Materi

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Buckstein, Rena, Lisa Chodirker, Michelle Geddes, et al. "Intermittent Transfusion Independence Is Associated with Improved Overall Survival in Patients with Transfusion Dependent MDS." Blood 134, Supplement_1 (2019): 5416. http://dx.doi.org/10.1182/blood-2019-129464.

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Background: More than 50% of patients with myelodysplastic syndrome (MDS) become transfusion dependent (TD) during the course of their disease and 25-30% present as TD at diagnosis. While TD is more common in IPSS/IPSS-R higher risk patients and is associated with inferior overall survival, it is unclear if achievement of transfusion independence (TI) for even short periods of time is associated with improved overall survival (OS). Objectives: Evaluate the impact of intermittent transfusion dependence and independence on OS in MDS patients and compare the OS with patients persistently TD or TI

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33

Kulagin, Aleksandr, Olesya Klimova, Tatiana Rudakova, et al. "Benefits and Limitations of Long-Term Eculizumab Treatment for Paroxysmal Nocturnal Hemoglobinuria (PNH): Real-World Data from Large Cohort Study in Russia." Blood 132, Supplement 1 (2018): 2589. http://dx.doi.org/10.1182/blood-2018-99-120139.

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Abstract Background: Anticomplement C5 therapy with eculizumab is the standard of treatment of patients (pts) with active hemolytic PNH. However, there are few data on long-term complement inhibition efficacy and current PNH prognosis from real-world clinical practice. Objectives: The aim of this study was to evaluate long-term eculizumab efficacy and PNH outcomes in the large cohort in Russia. Methods: As of August 1, 2018, a total of 354 pts with hemolytic PNH were observed in the I.P. Pavlov First St. Petersburg State Medical University in cooperation with the local hematological service in

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Bhamidipati, Pavan Kumar, John F. DiPersio, Keith Stokerl-Goldstein, et al. "Haploidentical Peripheral Blood Stem Cell Transplantation Using Non-Myeloablative Conditioning With Post-Transplant Cyclophosphamide Regimen Is Safe and Is Associated With Very Encouraging Post-Transplant Outcomes." Blood 122, no. 21 (2013): 4532. http://dx.doi.org/10.1182/blood.v122.21.4532.4532.

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Introduction The availability of HLA matched donors remains a major obstacle for successful allogeneic hematotopoietic cell transplantation. The use of HLA-mismatched alternate donors such as cord blood and haploidentical donor stem cell sources have allowed for greater access for those patients who need an allo-HSCT but lack a suitable matched sibling or unrelated donor. Introduction of high dose cytoxan in the early post-transplant period has significantly improved the outcomes of patients undergoing haploidentical transplantation and has eliminated the need for expensive and labor-intensive

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Blunt, Danielle N., Richard A. Wells, Martha Lenis, et al. "Health Related Quality of Life Remains Stable over Time in Myelodysplastic Syndrome: An MDS-CAN Prospective Study." Blood 132, Supplement 1 (2018): 4850. http://dx.doi.org/10.1182/blood-2018-99-114327.

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Abstract Background: Health-Related Quality of life (HRQoL) is diminished in patients with myelodysplastic syndrome (MDS). We have previously shown that HRQoL remains stable over time and low hemoglobin, transfusion dependence (TD) and age > 65 years impact QoL1. Here, we present an updated larger data set with longer follow up and consider the impact of baseline characteristics and treatments received on patient-related outcomes. Methods: MDS-CAN is a prospective database active in 15 centers across Canada, enrolling patients since April 2012. In addition to disease and patient-related cha

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Sheth, Kruti, Raffaele Girlanda, and Catherine Broome. "Complement Regulatory Gene Mutations in Non-Renal Solid Organ Transplant Recipients with Post-Transplant Thrombotic Microangiopathy." Blood 126, no. 23 (2015): 3463. http://dx.doi.org/10.1182/blood.v126.23.3463.3463.

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Abstract Complement dysregulation is central to the pathogenesis of atypical hemolytic uremic syndrome (aHUS). Mutations in genes encoding complement regulatory proteins (CRPs) can be identified in 61% of aHUS patients (Fremeaux-Bacchi 2013). In hematopoietic stem cell transplant (HSCT) recipients, all 6 children who developed post-transplant thrombotic microangiopathy (PT-TMA) were found to have a mutation in complement factor (CF) H related genes and/or the presence of CFH autoantibodies. In contrast, 18 children without evidence of PT-TMA had no mutations detected suggesting a strong role f

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Arnold, Louise M., Gemma L. Brooksbank, Richard J. Kelly, et al. "Continued Benefit From Prolonged Treatment with Eculizumab in 130 Patients with PNH in the UK: Home Delivery of Eculizumab Is Safe, Convenient and Associated with Very High Levels of Patient Satisfaction." Blood 118, no. 21 (2011): 4368. http://dx.doi.org/10.1182/blood.v118.21.4368.4368.

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Abstract Abstract 4368 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired bone marrow disorder characterised by intravascular hemolysis with resultant anemia often leading to transfusion dependence, severe disabling symptoms and, frequently, life threatening thrombosis. Historically the management of PNH was largely supportive, relatively ineffective and resulted in frequent visits to hospital, admissions, an inability to function normally including loss of employment or other daily activities. PNH is a chronic condition and in most patients persists for the remainder of the patient

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Nadarajah, Niroshan, Alex Wagner, Rafael Bejar, et al. "Creating a Variant Database for the American Society of Hematalogy By Consensus Variant Classification of Common Genes Associated with Hematologic Malignancies." Blood 136, Supplement 1 (2020): 4–5. http://dx.doi.org/10.1182/blood-2020-141204.

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Background: With the rapid decline of sequencing costs and the introduction of next-generation sequencing (NGS) instruments with higher processing capacity, the rate-limiting step in reporting genetic test results is moving away from sequencing production towards data interpretation. Powerful bioinformatics tools have been created to address this bottleneck. Though substantial advances have been made in clinical variant classification, much work remains. This is particularly true in the evaluation of somatic variants, where there is currently a high degree of variability in how members of the

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Djambas Khayat, Claudia, Johnny N. Mahlangu, Ross I. Baker, et al. "Rviii-Singlechain in Surgical Prophylaxis: Efficacy and Safety of Continuous and Bolus Infusion." Blood 126, no. 23 (2015): 3525. http://dx.doi.org/10.1182/blood.v126.23.3525.3525.

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Abstract Background: rVIII-SingleChain, a novel recombinant Factor VIII, has been designed as a B-domain truncated construct with a covalent bond between the heavy and light chain, aiming for a higher binding affinity to von Willebrand Factor. rVIII-SingleChain has a lower clearance, longer half-life and larger area under the curve compared to octocog alfa (Advate®). This sub-study of the AFFINITY program investigated the safety and efficacy of rVIII-SingleChain to control hemostasis in adult and adolescent patients (12 - 65 years of age) with severe Hemophilia A undergoing major surgery. rVII

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See, Kee Yon, Lionel, Kok Chong Bernard Yap, Dong-Wook Kim, Hein Than, and Yeow-Tee Goh. "Risk Factors Associated with Survival Outcome in Patients with Chronic Myeloid Leukaemia in Accelerated Phase Treated with Tyrosine Kinase Inhibitors." Blood 128, no. 22 (2016): 1222. http://dx.doi.org/10.1182/blood.v128.22.1222.1222.

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Abstract Chronic Myeloid Leukaemia (CML) is a triphasic disease which typically presents in chronic phase with risk of progression to more aggressive phases in a certain proportion of patients. Accelerated Phase (AP), as described in the pre-Tyrosine Kinase Inhibitor (TKI) era by Kantarjian et al in 1988, is an intermediate stage with a poor median overall survival (OS) of ≤18 months without haematopoietic stem cell transplantation (HSCT). Since TKI therapy has revolutionized CML treatment, a significantly improved OS has been seen in most CML patients, including those in AP. Not all CML-AP pa

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Putra, Esha Tegar. "MOTIF FIKSI POSMODERN DALAM ADAPTASI KABA CINDUA MATO." JENTERA: Jurnal Kajian Sastra 6, no. 1 (2017). http://dx.doi.org/10.26499/jentera.v6i1.256.

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In Minangkabau cosmology, Kaba Cindua Mato occupies an important position. Kaba is a representation of the balance, orderliness, and the structure of Minangkabau society. The structure of the story is arranged genealogically, tracing the presence of Bundo Kanduang as an analogy of the 'nature' of Minangkabau so that Kaba Cindua Mato can be said as an ideal image of the Minangkabau. This idealization makes Kaba Cindua Mato popular from time to time. The story in the kaba continues to experience the process of transformation, from oral stories to written text, audio, and video. Tito Alexi's Cind

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Jimenez, Rafael E. "The Tsar’s doctor: The selfless and devoted life of Dr Eugene Botkin." Journal of Medical Biography, June 28, 2020, 096777202093502. http://dx.doi.org/10.1177/0967772020935021.

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Eugene Botkin was Nicholas II’s court physician from 1908 until the abolition of the monarchy. He accompanied the royal family into exile and shared their fate at Ekaterinburg in 1918. The son of a prominent St. Petersburg physician, he trained at the Universities of St. Petersburg, Berlin, and Heidelberg. As court physician, he participated in the management of the Tsarevich Alexei’s hemophilia, but most of his time was spent taking care of the Tsarina’s multiple psychosomatic ailments. A deep sense of duty, rendered him unable to part from the royal family during the difficult months of exil

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Dean, Jay B. "Inquisitive doctor, reluctant patient: the story of Alexis St. Martin's gastric fistula and America's first physiologist, Dr. William Beaumont, who discovered gastric juice and the physiology of digestion (1822–1833; video shown by permission of the Mackinac Island State Park Commission)." FASEB Journal 26, S1 (2012). http://dx.doi.org/10.1096/fasebj.26.1_supplement.1125.1.

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