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Dissertations / Theses on the topic 'ST2/IL-33'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Arshad, Muhammad Imran. "Role of IL-33/ST2 axis in acute hepatitis." Rennes 1, 2012. http://www.theses.fr/2012REN1B103.

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L'interleukine-33 (IL-33), une cytokine de type alarmine de la famille de l’IL-1, est essentiellement exprimée par les cellules endothéliales et les cellules épithéliales dans diverses pathologies inflammatoires chez la souris et chez l'Homme. IL-33 induit son activité biologique par l'interaction d’un récepteur hétérodimérique composé de ST2 et IL-1RAcP. Les nouvelles sources cellulaires de l'IL-33 et la régulation de son expression restent mal connues dans le foie. L'objectif de ma thèse était de mieux comprendre les mécanismes d'expression, de régulation et d’activité de l'IL-33 en tant qu’

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2

Alyahyaei, Zahraa. "The role of IL-33 and ST2 in early pregnancy." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a6fd7c02-feeb-4fe5-b8e1-5713a65653b9.

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Regulation of the growth and differentiation of trophoblast cells is critical for successful embryo implantation and placentation. Cytokines are key players in these processes, as well as modulating the maternal immune response to prevent rejection of the conceptus. This thesis focused on the investigation of the cytokine interleukin (IL) - 33 and its receptor, ST2. ST2 has two isoforms, a functional cell surface receptor (ST2L) and a soluble decoy receptor (sST2). Previous work in this laboratory had shown that the human placenta expresses both IL-33 and sST2 at term. The aim of this thesis w

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3

Murphy, Grace E. J. "IL-33 and ST2 in innate and adaptive airway inflammation." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6685/.

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Background: ST2 has been identified in playing an important role in Th2-mediated inflammation and asthma. IL-33 acts as the ligand for ST2; it is a novel cytokine that induces innate Th2/type-2 responses when delivered to the lung. The hierarchy of IL-33 and type-2 cytokines and chemokines in Th2 inflammation in the lung has not been fully elucidated. Furthermore, the role of IL-33 in the adaptive response in allergic mediated airways disease is unclear. Epithelial cells (ECs) are increasingly recognised as having an immunological role in airway inflammation and asthma, in particular releasing

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4

Pitman, Nicholas Ian. "The role of IL-33 and ST2 in allergic airways disease." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1817/.

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Asthma is a chronic disease characterised by variable airflow obstruction, bronchial hyperresponsiveness and airways inflammation. At an immunological level Th2 inflammation and the presence of activated eosinophils and mast cells are key features of asthma. ST2, the receptor for the novel cytokine IL-33, is expressed upon Th2 lymphocytes and mast cells but its role in clinical and experimental asthma remains unclear. IL-33 has been shown to induce local and systemic eosinophilia when administered to the peritoneum of mice. In this thesis I have set out to test the hypothesis that the activati

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5

Kewin, Peter. "The role of IL-33 and ST2 in innate and adaptive inflammation." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444379.

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6

Ferrari, Larissa Staurengo. "Participação da IL-33/ST2 em modelo de artrite séptica em camundongos." Universidade Estadual de Londrina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Patologia Experimental, 2011. http://www.bibliotecadigital.uel.br/document/?code=vtls000163964.

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A preparação da suspensão bacteriana e o intervalo de confiança de UFC nessa suspensão é um importante procedimento utilizado em laboratórios como métodos para avaliação de respostas inflamatórias e pode ser obtido por diferentes métodos, tais como diuições seriadas e pela análisa visual da turbidez através da escala de McFarland. Nós investigamos a influência do armazenamento da suspensão de Staphylococcus aureus na viabilidade de bactérias e sua influência na inflamação induzida por essa suspensão. O armazenamento da suspensão de S. aureus a 8 º C por 24 h diminuiu a viabilidade bacteriana n

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7

Li, Xiaofei. "The IL-33/ST2 pathway in CNS : Traumatic brain injury and brain tumour." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183937.

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Interleukin 33 (IL-33) is a dual function cytokine. It is a member of the IL-1 family and it acts as a pro-inflammatory factor (18 kilo Dalton, 18 kD) like other cytokines in IL-1 family. IL-33 is also a transcription factor (32 kD - form) which can suppress or activate gene transcription in diverse cases. A variety of cell types and tissues in the central nervous system (CNS) can release IL-33 after injury. The 18 kD IL-33 binds to the membrane receptor protein ST2 ligand, then regulates downstream gene expression, triggers cytokine synthesis, and modulates the immune system response. After t

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8

Amôr, Nádia Ghinelli. "Papel do receptor ST2 no desenvolvimento de carcinoma espinocelular induzido quimicamente." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-26042016-112036/.

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O carcinoma espinocelular (CEC) é um dos cânceres humanos mais incidentes. A despeito do entendimento da fisiopatologia do CEC, as opções terapêuticas ainda são limitadas e o(s) exato(s) mecanismo(s) envolvido(s) na progressão deste tipo de tumor ainda não foi descrito. Estudos recentes mostram a existência de uma associação direta entre a resposta imune TH1 e um melhor prognóstico em pacientes com CEC. Aumento da expressão de componentes do eixo IL-33/ST2 foi demonstrado contribuir para transformação neoplásica em diversos modelos tumorais, incluindo cânceres de estômago e de mama. Trabalho r

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9

Tariq, Mubashira. "IL-33/ST2 and tissue Treg/AREG pathways in the pathophysiology of HIV infection." Electronic Thesis or Diss., Paris 12, 2021. http://www.theses.fr/2021PA120017.

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Depuis les thérapies antirétrovirales (ART), les principales causes de mortalité et de morbidité sont liées à des pathologies non liées aux SIDA qui sont dûes à un niveau d’inflammation chronique de bas bruit. Cette inflammation est liée entre autre à la persistance de la perte d’homéostasie intestinale qui conduit à des translocations microbiennes dans la circulation systémique. En effet, les sujets traités et infectés par le VIH présentent une déplétion sévère et massive des lymphocytes T CD4+, en particulier dans le tissu lymphoïde associé à l'intestin (GALT) une altération de la barrière é

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10

Fanny, Manoussa. "Etude des mécanismes de l’inflammation pulmonaire lors de l’exposition aux nanoparticules ou la fumée de cigarette : implication des voies de signalisations des récepteurs ST2 et NLRP6." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2057/document.

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Les maladies pulmonaires, responsables de 3,1 millions de décès de part le monde représentent un problème majeur de santé publique. En particulier, la fibrose pulmonaire et la broncho-pneumopathie chronique obstructive (BPCO) conduisent à la perte de la fonction pulmonaire. Aucun traitement efficace n’a été identifié à ce jour pour lutter contre ces maladies, la seule alternative étant la transplantation. Au cours de ma thèse, j’ai exploré les mécanismes du développement de ces maladies en utilisant différents modèles chez la souris, soit par l’instillation de nanoparticules de métaux ou de bl

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11

Stolarski, Bartosz. "The role of IL 33/ST2 pathway in innate immune response in airway inflammation." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2961/.

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Asthma is a common and complex inflammatory disease of the airways characterized by deregulated immune responses that involves activation of multiple cell types including Th2 cells, IgE producing B cells, mast cells, basophils and eosinophils as well as resident lung cells such as epithelial, smooth muscle cells and macrophages. Despite intensive research, there are still unmet needs in the treatment of asthma. Recently, a new cytokine of IL 1 family, named IL 33 emerged as a potentially important factor in the immunopathogenesis of allergy and asthma. It was recently shown in our laboratory t

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12

Bignardi, Letícia Andreotti. "Estudo do papel do eixo IL-33/ST2 na progressão da lesão periapical experimental." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/58/58135/tde-02022015-114411/.

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A citocina IL-33 apresenta papel dual e está envolvida com a resolução ou progressão de inúmeras doenças, além disso, acredita-se que a via IL-33/ST2 esteja envolvida no equilíbrio entre a atividade de osteoclastos e osteoblastos. O objetivo deste estudo foi avaliar o papel do receptor ST2 no desenvolvimento e progressão de lesões periapicais experimentalmente induzidas em camundongos. Lesões periapicais foram induzidas em primeiros molares inferiores de camundongos WT e ST2 knockout (KO). Decorridos 7 e 14 dias, as amostras de mandíbula foram submetidas às análises: determinação da área de le

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13

Rabes, Anne [Verfasser]. "ST2 and IL-33 differentially regulate the innate immune response to Streptococcus pneumoniae / Anne Rabes." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1065234066/34.

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14

Ball, Dimity. "Characterisation of IL-33/ST2 signaling and crosstalk in mast cells and their modulation by ES-62." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4750/.

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In addition to their role in fighting infection, mast cells have long been implicated in the pathogenesis of allergic and autoimmune inflammatory diseases and cancers. Increasingly, however, there is recognition that these cells may also play a part in protecting against development of pathologies. Indeed, there is increasing evidence that mast cells comprise heterogeneous phenotypes that exhibit functional plasticity to allow them to play both pro- and anti-inflammatory roles during an immune response. This plasticity appears to reflect that immature mast cells are tailored by their particula

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15

NASCIMENTO, Wheverton Ricardo Correia do. "Determinação dos níveis de IL-33, ST2 e quimiocinas em pacientes alérgicos e com esquistossomose mansoni ou geohelmintíases." UNIVERSIDADE FEDERAL DE PERNAMBUCO, 2017. https://repositorio.ufpe.br/handle/123456789/25131.

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Submitted by Fernanda Rodrigues de Lima (fernanda.rlima@ufpe.br) on 2018-07-17T22:16:51Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) TESE Wheverton Ricardo Correia do Nascimento.pdf: 3005039 bytes, checksum: 584879c98cbd13747a52ce9dd7c5e6dd (MD5)<br>Approved for entry into archive by Alice Araujo (alice.caraujo@ufpe.br) on 2018-07-19T22:25:38Z (GMT) No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) TESE Wheverton Ricardo Correia do Nascimento.pdf: 3005039 bytes, checksum: 584879c98cbd13747a52ce9dd7c5e

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16

SITZIA, CLEMENTINA. "UNVEILING CARDIAC IL-33/ST2L PATHWAY DEREGULATION IN ANIMAL MODEL OF OBESITY AND CARDIOVASCULAR DISEASE." Doctoral thesis, Università degli Studi di Milano, 2023. https://hdl.handle.net/2434/951892.

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Obesity has become an increasing public health issue worldwide; it is estimated than over 65% of American adult population is overweight and 35% are actually obese. Criteria for obesity definition is traditionally linked to Body Mass Index (BMI). Although an important correlation exists between BMI and body fat deposit, the BMI criteria cannot actually predict body composition in any given individual due to variability determined by age, sex, race and ethnicity. Besides the weight of an individual, both fat localization and type represent more important estimators of cardiovascular disease. Im

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17

Mirey, Emilie. "L' interleukine-33, un nouvel acteur de la réponse anti-tumorale dans un modèle murin de cancer du côlon." Toulouse 3, 2014. http://www.theses.fr/2014TOU30116.

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L'interleukine-33 (IL-33) est une cytokine nucléaire de la famille des interleukines-1. L'IL-33 est exprimée par de nombreux épithéliums en contact avec l'environnement et peut être libérée sous sa forme pleine taille lors de nécrose. Cette forme active peut interagir avec le récepteur ST2 appartenant à la famille des récepteurs de l'IL-1 (IL-1R4). ST2 est présent sur de nombreuses cellules du système immunitaire aussi bien impliquées dans l'immunité innée (cellules lymphoïdes innées de type 2 ou ILC2, mastocytes, NK,. . . ) qu'adaptative (lymphocytes Th2, T CD8,. . . ). L'ensemble de ces prop

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18

Levescot, AnaÏs. "L’hypothèse d’un contrôle extrinsèque de la leucémie myéloïde chronique : place des lymphocytes iNKT et de la cytokine/alarmine IL-3." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA114835.

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Les traitements actuels de la leucémie myéloïde chronique (LMC) ne permettent pas d’éliminer la totalité des cellules leucémiques. Dans le but de développer un traitement curatif, il est donc nécessaire de parvenir à une meilleure compréhension des mécanismes sous-jacents des réponses partielles aux traitements, Dans ce travail, nous avons postulé qu’il existe des mécanismes de contrôle extrinsèques de la LMC pouvant influencer l’efficacité des différents traitements. Nous avons choisi d’étudier le rôle potentiel dans la LMC des lymphocytes iNKT, cellules T de type « inné » auxquelles la litté

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19

Sehnine, Mohammed. "Implication du récepteur ST2 de l'alarmine interleukin-33 dans le phénomène d'ischémie/reperfusion rénale : étude de l'influence d'un environnement hyperglycémique." Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT1407.

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La transplantation rénale (TR) est la stratégie thérapeutique de choix pour les insuffisances rénales terminales. L'utilisation de greffons de donneurs à critères étendus, tels les sujets diabétiques, est devenue une nécessité face à la pénurie de greffons, malgré le risque accru de dysfonction du greffon. L'ischémie/reperfusion (I/R) est une étape inhérente à la TR. Le diabète est un facteur de risque pour le développement de lésions rénales aiguës mais les mécanismes d'action mis en jeu restent à élucider. Il existe peu de données expérimentales sur les conséquences délétères du diabète sur

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20

Mair, Iris. "Investigating mechanisms of regulatory T cell function in inflammatory disease." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28705.

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Regulatory T cells (Treg) play a crucial role in controlling immune homeostasis. Several inflammatory diseases including multiple sclerosis and inflammatory bowel disease have been associated with dysfunctional and/or reduced numbers of Treg. While several mechanisms of action have been discovered by which Treg can exert their function, disease-specific Treg requirements remain unknown. The Treg pool consists of highly diverse subpopulations, indicating that there is a potential to optimise Treg-targeted therapies if disease-relevant mechanisms can be established. Microarray data from our lab

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21

Wagner, Annika [Verfasser], Beatrix [Akademischer Betreuer] Süß, and M. Cristina [Akademischer Betreuer] Cardoso. "Evaluation des Sphingolipid- und IL-33/ST2-Signalwegs als Quelle für diagnostische Biomarker für die limitierte Form der systemischen Sklerose / Annika Wagner. Betreuer: Beatrix Süß ; M. Cristina Cardoso." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2015. http://d-nb.info/1111910332/34.

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22

Wagner, Annika. "Evaluation des Sphingolipid- und IL-33/ST2-Signalwegs als Quelle für diagnostische Biomarker für die limitierte Form der systemischen Sklerose." Phd thesis, 2015. http://tuprints.ulb.tu-darmstadt.de/4619/1/Dissertation%20A.Wagner_2015_ULB%20Version%202.pdf.

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Die Pathophysiologie der systemischen Sklerose (Sklerodermie, SSc) ist bisher unvollständig erforscht. Die Sklerodermie ist eine immun-mediierte Systemerkrankung, gekennzeichnet durch eine Fibrose des Bindegewebes. Die unklare Pathophysiologie erschwert eine frühzeitige Diagnose und therapeutische Intervention bei den Patienten. Es wird angenommen, dass die vaskulären Endothelzellen, insbesondere die der mikrovaskulären Gefäße, eine wichtige Rolle zu Beginn der Erkrankung einnehmen. Erste sichtbare Anzeichen einer gestörten Mikrovaskulatur sind in über 90 % der SSc-Patienten bereits vor einer

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