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Relevant bibliographies by topics / Stabilization by drying

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Academic literature on the topic 'Stabilization by drying'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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Journal articles on the topic "Stabilization by drying"

1

McAdams, David, Dexiang Chen, and Debra Kristensen. "Spray drying and vaccine stabilization." Expert Review of Vaccines 11, no. 10 (2012): 1211–19. http://dx.doi.org/10.1586/erv.12.101.

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Ingvarsson, Pall Thor, Mingshi Yang, Hanne Mørck Nielsen, Jukka Rantanen, and Camilla Foged. "Stabilization of liposomes during drying." Expert Opinion on Drug Delivery 8, no. 3 (2011): 375–88. http://dx.doi.org/10.1517/17425247.2011.553219.

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Young, Madison A., Andrew T. Antczak, Amanda Wawak, Gloria D. Elliott, and Susan R. Trammell. "Light-assisted drying for protein stabilization." Journal of Biomedical Optics 23, no. 07 (2018): 1. http://dx.doi.org/10.1117/1.jbo.23.7.075007.

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Puapermpoonsiri, U., S. J. Ford, and C. F. van der Walle. "Stabilization of bacteriophage during freeze drying." International Journal of Pharmaceutics 389, no. 1-2 (2010): 168–75. http://dx.doi.org/10.1016/j.ijpharm.2010.01.034.

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Selivanov, A. S. "Stabilization of Cellulases Using Spray Drying." Engineering in Life Sciences 5, no. 1 (2005): 78–80. http://dx.doi.org/10.1002/elsc.200400053.

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Lovalenti, Phillip M., Jeff Anderl, Luisa Yee, et al. "Stabilization of Live Attenuated Influenza Vaccines by Freeze Drying, Spray Drying, and Foam Drying." Pharmaceutical Research 33, no. 5 (2016): 1144–60. http://dx.doi.org/10.1007/s11095-016-1860-1.

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Bojic, Nada, Ruzica Nikolic, Branimir Jugovic, Zvonimir Jugovic, and Milica Gvozdenovic. "Uniaxial tension of drying sieves." Chemical Industry 67, no. 4 (2013): 655–62. http://dx.doi.org/10.2298/hemind120824109b.

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Although the literature contains numerous studies that have been developed to describe the nonlinear behavior of drying sieves' operation, there are no papers in this which report deeper investigation of the drying sieve behavior when exposed to tension and thermo stabilization. The aim of this paper is to provide insight into the elastoplastic behavior of the thermo stabilized and not stabilized sieves subjected to the tensile force. Within this work both theoretical and experimental investigations were performed. The sieves were joined by using a spiral. In separate experiments tests of wire base and weft of the weave mesh were performed, both for thermo stabilized and not thermo stabilized sieves, sieves joining and the sieve thermo stabilization itself. It was established that the thermo stabilization of sieves provides for stability of sieves' dimensions and that open thermo stabilized drying sieve exhibits better mechanical properties and exploitation characteristics then the sieves joining.

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Castellanos-Rozo, José, Jaqueline A. Galvis-López, Nuri A. Merchán Castellanos, Elsa H. Manjarres-Hernández, and Alex L. Rojas. "Assessment of two sludge stabilization methods in a wastewater treatment plant in Sotaquirá, Colombia." Universitas Scientiarum 25, no. 1 (2020): 17–36. http://dx.doi.org/10.11144/javeriana.sc25-1.aots.

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Wastewater sludge is a by-product of waste water treatment; it is often employed in agricultural processes following appropriate microbiological stabilization. In this study, we evaluated two methods of sludge stabilization in the waste water treatment plant of Sotaquirá, Colombia. The two assessed stabilization methods were dewatering on drying beds and alkaline stabilization. The stabilization through dewatering on drying bed was carried out for five months. Alkaline stabilization was conducted for 96 hours with three concentrations of calcium oxide, 7%, 9%, and 13% w/w. Humidity, pH, organic carbon, phosphorus, organic nitrogen, fecal coliforms, somatic phages, total helminth eggs, and Salmonella sp. were monitored monthly for the sludge under dewatering treatment and at 0, 12, 24 hours for sludge under alkaline stabilization treatment. Both treatments succeded in eliminating Salmonella sp. Helminth eggs were eliminated by alkaline stabilization, whereas it was reduced to one or zero helminth eggs with the dewatering treatment. Somatic phages were eliminated with alkaline stabilization but were only reduced to 3.52 log CFU/g with the dewatering method. Dewatering on drying beds produced biosolids that can be used for soil restoration. Whereas alkaline stabilization produced biosolids that can be used for agricultural purposes. Alkaline stabilization with 9% and 13 % calcium oxide ostensibly reduced nitrogen and phosphorus contents in the sludge, whereas 7 % calcium affected less the phosphorus concentration of the sludge. These results indicate that sludge dewatering on drying beds is an effective sludge sanitation protocol to be implemented in small waste water treatment plants, such that in Sotaquirá, Colombia.

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Velasquez, Mary Michelle, and Casiana Blanca Villarino. "Comparison of Microwave Vacuum Drying with Traditional Rice Bran Stabilization Methods: Impact on Extracted Oil Quality." Proceedings 70, no. 1 (2020): 35. http://dx.doi.org/10.3390/foods_2020-07729.

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Rice bran requires a stabilization process to prevent the rapid development of rancidity upon rice milling. Common stabilization methods usually take a long time or are harsh, which lead to a decrease in rice bran quality (e.g., nutritional and sensory properties). Microwave vacuum drying is a potential stabilization method for rice bran that generates heat at a lower temperature and allows rapid mass and energy transfer leading to an increased drying rate, thus retaining quality. This study aimed to evaluate the effects of various stabilization methods, i.e., dry heating (DH), microwave heating (MH), vacuum drying (VD) and microwave vacuum drying (MVD), on the quality and antioxidant properties of rice bran oils. It was observed that VD and MVD resulted in better rice bran color retention. Oil extraction yield was significantly increased by MVD and DH compared to unstabilized rice bran. Stabilization of rice bran by MVD, DH and MH resulted in significantly lower free fatty acid content and peroxide values in extracted oils. Total antioxidant capacity and percentage of scavenging activities of rice bran oil samples, as determined using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) assays, were not significantly different. These results suggest that MVD is an efficient rice bran stabilization method that provides similar oil qualities to those produced using traditional stabilization methods.

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Talsma, Herre, Jong-Yuh Cherng, Heike Lehrmann, et al. "Stabilization of gene delivery systems by freeze-drying." International Journal of Pharmaceutics 157, no. 2 (1997): 233–38. http://dx.doi.org/10.1016/s0378-5173(97)00244-5.

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Dissertations / Theses on the topic "Stabilization by drying"

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Fujii, Sachie. "Studies on drying of sugar solutions and stabilization of dried foods by sugars." Kyoto University, 2014. http://hdl.handle.net/2433/189644.

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Goodrich, Raymond Paul Jr McKay Ian A. "Modification of membrane surfaces with carbohydrates : an approach for stabilization during freezing and drying /." Diss., Pasadena, Calif. : California Institute of Technology, 1990. http://resolver.caltech.edu/CaltechETD:etd-06072007-091301.

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Katayama, Derrick S. "Towards a mechanistic understanding of pharmaceutical protein stabilization in solution and the solid state /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2006.

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Thesis (Ph.D. in Pharmaceutical Sciences) -- University of Colorado at Denver and Health Sciences Center, 2006.<br>Typescript. Includes bibliographical references (leaves 159-173). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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Molina, Salinas Marion Del Carmen. "Studies on the stabilization of lyophilized lipid/DNA complexes during storage /." Connect to abstract via ProQuest. Full text is not available online, 2007.

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Lang, Rainer [Verfasser], and Gerhard [Akademischer Betreuer] Winter. "Virus-Like particle based vaccines : stabilization by freeze-drying and development of sustained release devices / Rainer Lang. Betreuer: Gerhard Winter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2008. http://d-nb.info/1028490534/34.

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Aschenbrenner, Mathias [Verfasser]. "The relevance of glassy state dynamics on structure formation and stabilization of bacteria during freeze-drying and subsequent storage / Mathias Aschenbrenner." München : Verlag Dr. Hut, 2014. http://d-nb.info/1055863141/34.

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Touzet, Antoine. "Méthodes innovantes de séchage de suspensions de nanocristaux." Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCE009.

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Les nouvelles molécules thérapeutiques présentent la plupart du temps une faible solubilité aqueuse, à l’origine d’une biodisponibilité restreinte lors de leur administration orale. La réduction de taille des cristaux de substance active à l’échelle submicronique (= production de nanocristaux) s’est imposée comme une voie majeure de formulation au cours de ces dernières années.Afin de pallier des problèmes d’instabilité et d’aboutir à des formes solides pratiques d’utilisation pour les patients, une étape de séchage est généralement effectuée après production des nanocristaux en suspension. L’objectif principal de cette étape est de générer un produit présentant à la fois des propriétés facilitant le déroulement d’étapes procédés avales mais aussi et surtout de prévenir l’agrégation des nanocristaux au risque de compromettre leur dissolution après administration.Plusieurs techniques sont aujourd’hui utilisées dans l’industrie pharmaceutique telle que l’enrobage/granulation en lit d’air fluidisé et le spray drying. Parallèlement à l’élaboration d’une « formulation standard » pour ces deux méthodes de référence, deux techniques innovantes de lyophilisation ont été investiguées dans ce travail. La stabilisation de nanocristaux de kétoconazole par cryopelletization et active freeze drying a été démontrée et les paramètres clefs identifiés. Les produits générés par ces deux techniques, respectivement sous forme de pellets ou de poudre fine, ont été comparés à ceux conçus par enrobage en lit d’air fluidisé et spray drying. En conclusion, ces travaux indiquent que la cryopelletization et l’active freeze drying se positionnent comme des procédés d’intérêt de seconde intention, permettant de traiter des cas particuliers (molécules sensibles au stress thermique, à l’humidité et/ou couteuses)<br>Newly active pharmaceutical ingredients very often suffer from low aqueous solubility, a fact that in many cases can lead to poor oral bioavailability. Nanosizing, referring to drug nanocrystals production by size reduction, has demonstrated over the past few years a great potential to overcome this major issue.Since solid oral dosage forms are generally preferred due to stability reasons and patient convenience, the production of nanocrystals in a liquid medium is usually followed by a drying step. The main objective of this drying step is to generate a product suitable for downstream processing operations while at the same time preventing nanocrystal aggregation which can adversely affect the dissolution performance of the dry product in vivo.Several drying techniques such as spray drying and coating/granulation in fluidized bed have been successfully implemented in the pharmaceutical industry. In this work, two innovative freeze drying techniques were investigated and compared to the two above mentioned reference methods. The suitability of cryopelletization and active freeze drying to stabilize ketoconazole nanocrystals has been demonstrated and the key process parameters identified. The formulations generated by these two innovative techniques in the form of pellets or fine powder particles, respectively, were compared to the previously manufactured by fluidized bed and spray drying. In conclusion, this work presents cryopelletization and active freeze drying as suitable second-line processes with potential to address the drying of formulations containing problematic molecules sensible to thermal stress, moisture and/or presenting high production costs

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Verlhac, Pierre. "Étude et optimisation des cycles de lyophilisation d’une souche probiotique modèle." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1037/document.

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Ce travail est basé sur l’étude expérimentale, étape par étape, du procédé de lyophilisation, afin de comprendre les impacts des différents paramètres du procédé sur la viabilité d’une souche modèle probiotique de type lactobacillus casei. Nous avons tout d’abord étudié les propriétés thermodynamiques des formulations considérées à base de lactose et de polyvinylpyrrolidone, (PVP) en commençant dans un premier temps par l’obtention du diagramme d’état du système amorphe constitué du binaire eau-PVP, puis le diagramme de fusion du ternaire eau-PVP-lactose afin d’en déduire les paramètres clefs pour l’optimisation des cycles de lyophilisation de ces suspensions bactériennes. Dans la deuxième partie, nous avons caractérisé par microscopie électronique à balayage (MEB) la localisation des bactéries au sein de la phase solide amorphe des lyophilisats poreux. Ensuite, les différentes formulations ont été soumises à différents protocoles de congélation (vitesse de refroidissement ; recuit) afin d’obtenir les meilleurs résultats en termes de taux de survie des bactéries. Avec la formulation sélectionnée précédemment nous nous sommes intéressés à l’influence des paramètres opératoires de sublimation (température étagère et pression totale de sublimation) conduisant aux meilleurs taux de survie des bactéries. Nous avons observé que nos cellules probiotiques, avec ces formulations, pouvaient être lyophilisées, au-dessus de la température limite de collapse, sans impacter la viabilité des cellules présentes ou insérées au sein de la phase matrice poreuse du lyophilisat final, ce dernier présentant de plus, de bonnes propriétés d’usage en termes de stabilité en vue d’une mise en forme galénique ou d’un stockage ultérieur<br>This work is based on the experimental study, step by step, of the freeze-drying process of a model probiotic strain of lactobacillus caseï type to understand the impact of the numerous factors (formulation; freezing protocol; operating conditions) on the survival rates of these bacteria in the final lyophilisate. Firstly, we investigated the thermo-dynamical and physical properties (vitreous transition and melting temperatures) of formulations based on lactose and polyvinylpyrrolidone (PVP) protectants and their mixture. Thus, we have determined the phase diagrams and the melting diagram of the water+PVP binary system and of the ternary water-PVP-lactose system. Next, we determined the optimal freezing protocol (freezing rates; annealing treatment) with different formulations which led to the best survival rates. Next, in a preliminary study we have characterized by SEM (scanning electron microscopy) the location of the cells inserted inside the solid amorphous phase of the porous matrix of the different lyophilisates. Secondly, with the pre-selected formulation, we experienced the influence of the main operating sublimation parameters (shelf temperature and total gas pressure), leading to highest product quality in terms of bacteria survival ratios of the final lyophilisates. We observed that these probiotics cells, with this formulation, could be freeze-dried above the limit collapse temperature without impacting significantly the viability of the freeze-dried cells and with lyophilisates of high stability attributes

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Silva, Tales Alexandre da Costa e. "Caracterização bioquímica e secagem em \"spray dryer\" de lipases produzidas pelo fungo endofítico Cercospora kikuchii." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-13122010-162349/.

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Lipases são enzimas que catalisam a hidrólise de triacilgliceróis em ácidos graxos, mono e diacilgliceróis e glicerol. Em contraste com as esterases, lipases são ativadas apenas quando estão adsorvidas a uma interface óleo-água. Lipases têm sido amplamente utilizadas em muitos processos industriais, tais como química orgânica, formulações de detergentes e de produtos como cosméticos e farmacêuticos. A principal preocupação na produção de enzimas comerciais é a proteção da sua estabilidade em solução aquosa. A água facilita ou medeia uma variedade de vias de degradação física e química, durante as etapas de purificação, transporte e armazenamento. Por conseguinte, formulações sólidas são desenvolvidas para alcançar uma vida útil aceitável para essas substâncias. Spray drying é comumente usado como uma técnica de desidratação na indústria farmacêutica para fabricação de produtos em pó diretamente do estado líquido. No presente trabalho, a purificação e caracterização bioquímica de lipases produzidas pelo fungo endofítico Cercospora kikuchii, bem como os efeitos de adjuvantes no processo de secagem destas enzimas foram estudados. A lipase bruta foi purificada à homogeneidade através de cromatografia de interação hidrofóbica e gel filtração. A lipase foi purificada 5,54 vezes, com rendimento de 9% e a atividade específica de 223,6 U/mg. O peso molecular da enzima foi estimado em 65,1 kDa por SDS-PAGE e 73,5 kDa utilizando cromatografia de gel filtração, indicando que provavelmente trata-se de um monômero. A lipase mostrou um pH ótimo em 4,6 e uma temperatura ótima de 35°C. Cerca de 80,2% de sua atividade foi mantida após incubação a 40°C durante 2 horas. A Vmax e Km foram 10,28 mmol/min/mg de proteína e 0,03240 mM, respectivamente, utilizando pNPP como substrato. As lipases presentes no extrato bruto e as lipases ligadas ao micélio foram caracterizadas para avaliar o potencial de utilização em biocatálise. A lipases no extrato bruto apresentaram atividade máxima a 60ºC e pH 6,2, enquanto que as lipases ligadas ao micélio apresentaram atividade máxima a 50ºC e pH 5,4. Nos estudos de efeito da temperatura sobre a atividade enzimática, as lipases no extrato bruto mantiveram-se estáveis a 50°C, com 85,3% de atividade residual após 2 horas de incubação. As lipases ligadas ao micélio mantiveram pelo menos 75,1% de atividade residual após 2 horas de incubação a 80°C. Estes resultados mostram que as lipases de C. kikuchii têm propriedades cinéticas e termoestabilidade desejáveis para aplicações em biocatálise. As lipases presentes no extrato bruto foram secas em spray dryer com diferentes adjuvantes, e sua estabilidade foi avaliada. A recuperação da atividade enzimática após a secagem, com a adição de 10% de lactose, -ciclodextrina, maltodextrina, manitol, goma arábica, e trealose variou de 63 a 100%. A atividade da enzima foi totalmente perdida durante a secagem do extrato bruto na ausência de adjuvantes. A maioria dos adjuvantes utilizados manteve pelo menos 50% da atividade enzimática a 5°C e 40% a 25°C, após 8 meses de armazenagem. As lipases secas com 10% de - ciclodextrina mantiveram 72% da atividade a 5°C no mesmo período. A partir destes resultados preliminares foi realizada a otimização do processo de secagem utilizando -ciclodextrina, maltodextrina e lactose como adjuvantes. A análise estatística dos resultados experimentais permitiu a determinação das condições ótimas para a retenção da atividade enzimática (RAE), a saber: concentração de adjuvantes de secagem de 12,05%, temperatura de entrada do gás de secagem em 153,6oC e vazão do extrato enzimático alimentado de 9,36 g/min, para - ciclodextrina e maltodextrina como adjuvantes. Para lactose, o estudo mostrou que o aumento da quantidade de adjuvante de secagem e/ou diminuindo a temperatura do gás de entrada tem um efeito positivo sobre a retenção da atividade enzimática do produto seco. Após o processo de purificação foi realizada a secagem da enzima parcialmente purificada e da lipase pura, com estes três adjuvantes. A manutenção da atividade enzimática variou 90,6-100% quando foram utilizadas as condições ótimas para cada adjuvante de secagem. Concluindo, as lipases produzidas por C. kikuchii podem ser eficientemente secas por spray dryer, uma vez que a atividade enzimática foi mantida no extrato bruto, na lipase pura e na lipase semi-purificada submetidas à secagem.<br>Lipases are enzymes that catalyze the hydrolysis of triacylglycerols to fatty acids, mono and diacylglycerols, and glycerol. In contrast to esterases, lipases are activated only when they are adsorbed to an oilwater interface. They have been widely used in many industrial processes such as organic chemical, detergent and cleaning formulations and in products like cosmetics and pharmaceutical products. The main concern in the production of commercial enzymes is to protect their stability in aqueous solution. Water facilitates or mediates a variety of physical and chemical degradation pathways, active during protein purification, shipping and storage. Consequently, dry solid formulations are developed to achieve an acceptable protein shelf life. Spray drying is commonly used as a dehydration technique in the pharmaceutical industry for making powdery products directly from the liquid. In the present work, the purification and biochemical characterization of lipases produced by endophytic fungus Cercospora kikuchii as well as the effects of adjuvants on the spray drying process of theses enzymes were studied. The crude lipase was purified to homogeneity by hydrophobic interaction chromatography and gel filtration. The lipase purified was 5.54-fold with 9% recovery and the specific activity was 223.6. The molecular mass of the lipase was estimated to be 65.1 kDa using SDS-PAGE and 73.5 using gel filtration chromatography, indicating that the lipase is a monomer. The lipase demonstrated an optimum pH at 4.6, an optimum temperature of 35°C. About 80.2% of its activity was retained after incubation at 40°C for 2 hours. The Vmax and Km were 10.28 mol/min/mg protein and 0.03240 mM, respectively, using pNPP as substrate. The lipases present in crude extract and the mycelium-bound lipases were characterized in order to evaluate the potential for use in biocatalysis. The crude extract showed maximum activity at 60ºC and pH 6.2 while the myceliumbound lipases showed maximum activity at 50ºC and pH 5.4. In tests of the temperature effect on the enzymatic activity, the lipases in the crude extract was stable at 50°C, with 85.3% residual activity after 2 hours of incubation. The mycelium-bound lipases maintained at least 75.1% of residual activity after 2 h incubation at 80°C. These results show that the lipases of C. kikuchii have kinetic properties and stability characteristics suitable to applications in biocatalysis. The lipases present in crude extract were spray dried with different adjuvants, and their stability was evaluated. The recovery of the enzyme after drying with 10% of lactose, -cyclodextrin, maltodextrin, mannitol, gum arabic, and trehalose ranged from 63% to 100%; but the enzyme activity was lost in the absence of adjuvants. Most of the adjuvants used kept up at least 50% of the enzymatic activity at 5°C and 40% at 25°C after 8 months. The lipase dried with 10% of -cyclodextrin retained 72% of activity at 5°C. From these preliminary results the optimization of drying process using -cyclodextrin, maltodextrin and lactose as adjuvants was carried out. Statistical optimization of the experimental results allowed the determination of the processing conditions that maximized the retention of the enzymatic activity (RAE), namely: concentration of drying adjuvants of 12.05 %, inlet temperature of the drying gas of 153.6oC, and flow rate of the enzymatic extract fed to the dryer of 9.36 g/min, for the b-cyclodextrin and maltodextrin as adjuvants. For lactose as adjuvant the study showed that increasing the amount of drying adjuvant and/or decreasing the inlet gas temperature has positive effect on the retention of enzymatic activity of the dried product. After the purification process was carried out the drying of the partially purified enzyme and pure lipase, using these three adjuvants. The retention of enzymatic activity ranged from 90.6 to 100% when was used the optimal conditions for each drying adjuvant. Concluding, the lipases produced by C. kikuchii may be efficiently spray dried since its activity enzimatic was retained in crude extract, pure lipase and in semi-purified lipase after drying.

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Vasudevamurthy, Madhusudan. "Betaine analogues and related compounds for biomedical applications." Thesis, University of Canterbury. Chemical and Process Engineering, 2006. http://hdl.handle.net/10092/1096.

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Living cells accumulate compensatory solutes for protection against the harmful effects of extreme environmental conditions such as high salinity, temperature and desiccation. Even at high concentrations these solutes do not disrupt the normal cellular functions and at times counteract by stabilizing the cellular components. These properties of compensatory solutes have been exploited for stabilizing proteins and cells in vitro. Betaines are widespread natural compensatory solutes that have also been used in other applications such as therapeutic agents and polymerase chain reaction (PCR) enhancers. Some biomedical applications of novel synthetic analogues of natural betaines were investigated. Natural compensatory solutes are either dipolar zwitterionic compounds or polyhydroxyl compounds, and the physical basis of compensation may differ between these, so one focus was on synthetic betaines with hydroxyl substituents. The majority of the synthetic solutes stabilized different model proteins against stress factors such as high and low temperatures. The presence of hydroxyl groups improved protection against desiccation. The observed stabilization effect is not just on the catalytic activity of the enzyme, but also on its structural conformation. Synthetic compensatory solutes have a potential application as protein stabilizers. Dimethylthetin was evaluated as a therapeutic agent and found to be harmful in a sheep model. However, from the study we were able to generate a large-animal continuous ambulatory peritoneal dialysis (CAPD) model and showed that glycine betaine could be added to the dialysis fluid in chronic renal failure. Some synthetic compensatory solutes reduce the melting temperatures of DNA better than most natural solutes. Synthetic solutes were identified that have potential to enhance PCR and could replace some reagents marketed by commercial suppliers. Density, viscosity and molecular model data on the solutes showed correlations with the biochemical effects of the solutes, but no physical measurements were found that reliably predicted their potential for biotechnological applications.

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Book chapters on the topic "Stabilization by drying"

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Reyes, L. A., M. I. Cortés-Vázquez, M. C. Oliver-Salvador, J. Yáñez-Fernández, and R. Briones-Martínez. "Refined Hemisphaericin Stabilization by Microencapsulation with Arabic Gum and Spray Drying." In Food Engineering Series. Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2578-0_54.

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Dráber, Pavel, Vadym Sulimenko, Tetyana Sulimenko, and Eduarda Dráberová. "Stabilization of Protein by Freeze-Drying in the Presence of Trehalose: A Case Study of Tubulin." In Methods in Molecular Biology. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-977-2_32.

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Dráber, Pavel, Vadym Sulimenko, Tetyana Sulimenko, and Eduarda Dráberová. "Stabilization of Proteins by Freeze-Drying in the Presence of Trehalose: A Case Study of Tubulin." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0775-6_27.

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Brümmer, Monika, Mª Paz Sáez-Pérez, and Jorge Durán Suárez. "Hemp-Clay Concretes for Environmental Building—Features that Attribute to Drying, Stabilization with Lime, Water Uptake and Mechanical Strength." In Advances in Natural Fibre Composites. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64641-1_21.

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Logan, Terry J., and Jeffrey C. Burnham. "The Alkaline Stabilization with Accelerated Drying Process (N-Viro): An Advanced Technology to Convert Sewage Sludge into a Soil Product." In Agricultural Utilization of Urban and Industrial By-Products. American Society of Agronomy, Inc., Crop Science Society of America, Inc., Soil Science Society of America, Inc., 2015. http://dx.doi.org/10.2134/asaspecpub58.c10.

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Crowe, John, Nelly Tsvetkova, Ann Oliver, Chad Leidy, Josette Ricker, and Lois Crowe. "Stabilization of Liposomes by Freeze-Drying." In Liposome Technology, Volume I. Informa Healthcare, 2006. http://dx.doi.org/10.1201/9780849397264.ch13.

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Crowe, John, Lois Crowe, Fern Tablin, Willem Wolkers, Ann Oliver, and Nelly Tsvetkova. "Stabilization of Cells during Freeze-Drying." In Life in the Frozen State. CRC Press, 2004. http://dx.doi.org/10.1201/9780203647073.ch21.

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Guangyin, Zhen, and Zhao Youcai. "Sewage Sludge Solidification/Stabilization and Drying/Incineration Process." In Pollution Control and Resource Recovery. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-811639-5.00003-6.

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"Mechanisms of Protein Stabilization During Freeze-Drying Storage: The Relative Importance of Thermodynamic Stabilization and Glassy State Relaxation Dynamics." In Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products. CRC Press, 2016. http://dx.doi.org/10.3109/9781439825761-11.

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Pikal, Michael. "Mechanisms of Protein Stabilization during Freeze-Drying and Storage." In Drugs and the Pharmaceutical Sciences. Informa Healthcare, 2004. http://dx.doi.org/10.1201/9780203021323.ch3.

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Conference papers on the topic "Stabilization by drying"

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Rivera, Daniel, Mariana Valverde, Ana Valera, et al. "Stabilization of Lactobacillus sp. with enhanced thermal resistance by spray-drying." In 21st International Drying Symposium. Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7625.

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Combining biotechnology and encapsulation by spray-drying is possible to obtain microorganisms-based products in powder format without losing viability. A methodology based on the improvement of the thermal stress resistance of selected strains of Lactobacillus sp. and subsequent culture stabilization by spray-drying by optimizing the process parameters and using thermal protectant materials has been developed. The results obtained showed that the final product kept the viability of the initial culture in addition to be a solid, powdery and ease-to-handle product. Keywords: thermal resistance; spray-drying; probiotics; viability; fermentation; encapsulation.

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Zhang, Mingjian, Feng Huang, Qing Chen, et al. "The prediction model of moisture content’s stabilization during tobacco strip drying process." In 21st International Drying Symposium. Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7409.

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A mathematical model was established to predict the mean value and variance of tobacco strip during drying processing, based that the physical and chemical properties of tobacco strip as agriculture products show probability distributions. The results show that the model can predict the mean value of moisture content at different times, and there is a certain deviation in predicting the variance of moisture content at initial stage of drying process. However, the prediction value of the variance of tobacco strip is much more accurate while the moisture content is between 8% and 10%, which is the interval of quality requirements.Keywords: tobacco strip; drying; mean value;variance model.

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Acosta-Piantini, Elsa Maritza, M. Carmen Villaran, and J. Ignacio Lombraña. "Stabilization of encapsulated probiotics from the bacterium Lactobacillus casei by different drying techniques." In 21st International Drying Symposium. Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7744.

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The main objective of this work is to encapsulate and dry the bacterium probiotic Lactobacillus casei applying three different drying techniques (lyophilization, fluidized bed and flash freeze drying) as well as to evaluate their viability during storage in the dark at 20ºC and 34% relative humidity for 28 days. In addition, to compare viability of the bacterium processed with flash freeze drying with cryoprotectant (skim milk) and without cryoprotectant. In the case of flash freeze drying, the final level of viability shows the potential of this drying technique with much less operating costs than lyophilization. Keywords: Encapsulated, probiotics, lactobacillus, casei, drying

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Ohtake, S., A. Langford, B. Balthazor, et al. "Beyond freeze-drying of biologics: vacuum-foam drying and spray freeze-drying." In 21st International Drying Symposium. Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7855.

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The complexity of biotherapeutics in development continues to increase as our capability in discovery and recombinant technology improves. While safety and efficacy remain the two critical aspects of all therapeutics, ensuring adequate stability is a challenge. Freeze-drying is a commonly-used processing technique to enhance the stability of biotherapeutic products, although the lengthy process time and low energy efficiency have led to the search for, and evaluation of, next-generation drying technologies, including spray freeze-drying and vaccum-foam drying. Both processes result in dosage forms that vary considerably from those produced by lyophilization and possess physical properties that may be deemed superior for their intended applications. Keywords: vacuum-foam drying; spray freeze-drying; lyophilization; biotherapeutics; stabilization

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Piecko, Jan, Dorota Konopacka, Monika Mieszczakowska-Frąc, Dorota Kruczyńska, and Karolina Celejewska. "Drying kinetics and selected physico - chemical properties of fresh cranberries preserved with microwave – vacuum process." In 21st International Drying Symposium. Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.8365.

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A one stage drying process for dried cranberry production, employing a vacuum microwave technique, is proposed. The process consists of a specific sequence of microwave energy dosage at a given vacuum level. During the 60 minute process, three sub-stages can be identified: osmotic dehydration, intensive water evaporation and stabilization. Mass transfer, as well as quality changes during the process, has been described, and the final product quality compared to purchased control. The proposed method of dried cranberry production resulted in a microbiologically stable product (aw=0.62) of a decent sensory quality, with an antioxidant potential three times higher than traditional products. Keywords: Vaccinium macrocarpon; microwave-vacuum drying; ready-to-eat snack

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Scutellà, Bernadette, Ioan Cristian Trelea, Erwan Bourlés, Fernanda Fonseca, and Stephanie Passot. "Use of a multi-vial mathematical model to design freeze-drying cycles for pharmaceuticals at known risk of failure." In 21st International Drying Symposium. Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7421.

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Freeze-drying is a dehydration method suitable for the stabilization of heat-labile pharmaceutical products, such as vaccines. Due to the vial-to-vial variability of heat and mass transfer during the process, the value of the critical process parameters (e.g., product temperature, sublimation rate) may be different between vials and batches often present significant product quality heterogeneity. The aim of this work was the development of a dynamic, multi-vial mathematical model making it possible to predict risk of failure of the process, defined as the percentage of vials potentially rejected by quality inspection. This tool could assist the design of freeze-drying cycle. Keywords: lyophilization; vaccines; heat and mass transfer; mathematical modeling; design space

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Oliveira, Wanderley Pereira, Tales Alexandre Costa-Silva, Ana Karine Furtado Carvalho, Claudia Regina Fernandes Souza, Larissa De Freitas, and Heizir F. Castro. "Immobilization of Candida rugosa lipase on eco-friendly supports by spouted-bed technology: Use in the synthesis of isoamyl caprylate." In 21st International Drying Symposium. Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7544.

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Candida rugosa lipase (LCR) was immobilized on low-cost supports (by-products) and dried using a spouted-bed system. The yields of immobilized derivatives were in the range 61.5–78.7%. Lipase immobilized on rice husk showed the best results, presenting 94.1% of the original activity, followed by sugarcane bagasse (90.3%) and green coconut fiber (87.3%). Moisture content in the obtained powders varied between 4.7 and 5.6% and the water activities were in the range 0.21–0.35. Among all the tested biocatalysts for aroma production the lipase immobilized on rice husk showed the highest activity towards the formation of isoamyl caprylate (62.40 g.L-1). Keywords: Spouted bed dryer; Enzyme dehydration; Enzyme immobilization; Enzyme stabilization; Aroma production.

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Cárcel, Juan A., Matheus P. Martins, Edgar J. Cortés, Carmen Rosselló, and Ramón Peña. "Influence of the temperature and ultrasound application in drying kinetics of apple skin." In 21st International Drying Symposium. Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7889.

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The great amount of waste produced by food industry contains interesting bioactive compounds. The extraction of these compounds requires the by-products previous stabilization being the convective drying one of most used techniques to this end. Drying conditions can affect both drying kinetics and final quality of products. The apple skin, byproduct of apple juice or cider industries, is rich in functional compounds such as polyphenols or vitamin C. The main goal of this contribution was to quantify the influence of temperature and ultrasound application in drying kinetics of apple skin. For this purpose, drying experiments at different temperatures (-10, 30, 50 and 70 ºC) and with (20.5 kW/m3) and without application of ultrasound were carried out. Drying kinetics were modelled by using a diffusion based model. As can be expected, the higher the temperature the faster the drying. Ultrasound application accelerated the process at every temperature tested being the influence slightly lower than found from the literature for other products. This can be attributed at the physical structure of the apple skin, less porous than the pulp. In any case, the application of ultrasound significantly reduced the drying time. Keywords: by-products; dehydration;diffusivity; mass transfer

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Trammell, Susan R., Madison E. McKinnon, Gloria D. Elliott, and Madison A. Young. "Light assisted drying (LAD) for protein stabilization: optical characterization of samples." In Optics and Biophotonics in Low-Resource Settings IV, edited by David Levitz, Aydogan Ozcan, and David Erickson. SPIE, 2018. http://dx.doi.org/10.1117/12.2290415.

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Furr, Daniel P., Phuong A. Lam, Allison Tran, et al. "Thermal stabilization of nuclei acid nanoparticles (NANPs) using light-assisted drying." In Colloidal Nanoparticles for Biomedical Applications XVI, edited by Marek Osiński and Antonios G. Kanaras. SPIE, 2021. http://dx.doi.org/10.1117/12.2577763.

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