Academic literature on the topic 'Stabilizing selection'

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Journal articles on the topic "Stabilizing selection"

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Beaumont, M. A. "Stabilizing selection and metabolism." Heredity 61, no. 3 (1988): 433–38. http://dx.doi.org/10.1038/hdy.1988.135.

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Zhang, Xu-Sheng, and William G. Hill. "Joint Effects of Pleiotropic Selection and Stabilizing Selection on the Maintenance of Quantitative Genetic Variation at Mutation-Selection Balance." Genetics 162, no. 1 (2002): 459–71. http://dx.doi.org/10.1093/genetics/162.1.459.

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AbstractIn quantitative genetics, there are two basic “conflicting” observations: abundant polygenic variation and strong stabilizing selection that should rapidly deplete that variation. This conflict, although having attracted much theoretical attention, still stands open. Two classes of model have been proposed: real stabilizing selection directly on the metric trait under study and apparent stabilizing selection caused solely by the deleterious pleiotropic side effects of mutations on fitness. Here these models are combined and the total stabilizing selection observed is assumed to derive
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Godfrey, P. Brighten, Matthew Caesar, Ian Haken, Yaron Singer, Scott Shenker, and Ion Stoica. "Stabilizing Route Selection in BGP." IEEE/ACM Transactions on Networking 23, no. 1 (2015): 282–99. http://dx.doi.org/10.1109/tnet.2014.2299795.

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Hastings, Alan. "Substitution Rates Under Stabilizing Selection." Genetics 116, no. 3 (1987): 479–86. http://dx.doi.org/10.1093/genetics/116.3.479.

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ABSTRACT Allelic substitutions under stabilizing phenotypic selection on quantitative traits are studied in Monte Carlo simulations of 8 and 16 loci. The results are compared and contrasted to analytical models based on work of M. Kimura for two and "infinite" loci. Selection strengths of S = 4Nes approximately four (which correspond to reasonable strengths of selection for quantitative characters) can retard substitution rates tenfold relative to rates under neutrality. An important finding is a strong dependence of per locus substitution rates on the number of loci.
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Zhivotovsky, Lev A., and Freddy Bugge Christiansen. "The Selection Barrier between Populations Subject to Stabilizing Selection." Evolution 49, no. 3 (1995): 490. http://dx.doi.org/10.2307/2410273.

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KODRIC-BROWN, ASTRID, and MARLIES E. HOHMANN. "Sexual selection is stabilizing selection in pupfish (Cyprinodon pecosensis)." Biological Journal of the Linnean Society 40, no. 2 (1990): 113–23. http://dx.doi.org/10.1111/j.1095-8312.1990.tb01972.x.

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Zhivotovsky, Lev A., and Freddy Bugge Christiansen. "THE SELECTION BARRIER BETWEEN POPULATIONS SUBJECT TO STABILIZING SELECTION." Evolution 49, no. 3 (1995): 490–501. http://dx.doi.org/10.1111/j.1558-5646.1995.tb02281.x.

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PLAETKE, ROSEMARIE, JAAKKO LUMME, and WOLFGANG KOEHLER. "Selection on recombination in subdivided populations with stabilizing selection." Hereditas 109, no. 1 (2008): 61–67. http://dx.doi.org/10.1111/j.1601-5223.1988.tb00183.x.

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Charlesworth, Brian. "Stabilizing Selection, Purifying Selection, and Mutational Bias in Finite Populations." Genetics 194, no. 4 (2013): 955–71. http://dx.doi.org/10.1534/genetics.113.151555.

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Keightley, Peter D., and William G. Hill. "Quantitative genetic variability maintained by mutation-stabilizing selection balance: sampling variation and response to subsequent directional selection." Genetical Research 54, no. 1 (1989): 45–58. http://dx.doi.org/10.1017/s0016672300028366.

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SummaryA model of genetic variation of a quantitative character subject to the simultaneous effects of mutation, selection and drift is investigated. Predictions are obtained for the variance of the genetic variance among independent lines at equilibrium with stabilizing selection. These indicate that the coefficient of variation of the genetic variance among lines is relatively insensitive to the strength of stabilizing selection on the character. The effects on the genetic variance of a change of mode of selection from stabilizing to directional selection are investigated. This is intended t
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Dissertations / Theses on the topic "Stabilizing selection"

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Iakovleva, Irina. "Selection of transthyretin amyloid inhibitors." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123939.

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Amyloidosis is a group of clinical disorders caused by the aggregation of specific proteins into abnormal extracellular deposits. Today, 31 different proteins have been linked to amyloid diseases including transthyretin-related amyloidosis (ATTR). ATTR occurs through the aggregation of either wild-type plasma protein transthyretin (TTR) or a mutated form. TTR is a homotetramer that under normal circumstances functions as a carrier of thyroxine and retinol binding protein. The aggregation cascade requires dissociation of the tetramer into monomers, and preventing this dissociation represents a
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Ferrer, i. Admetlla Anna. "Human genetic diversity in genes related to host-pathogen interactions." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7163.

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La tesi que teniu a les mans recull quatre treballs amb un objectiu comú; determinar si els patògens (virus, bacteris, paràsits.) han exercit pressions selectives sobre els genomes dels seus hostes (com per exemple els humans).<br/>Sabent que la detecció de l'empremta de la selecció permet identificar aquelles regions del genoma que han estat rellevants al llarg de l'evolució d'una espècie, ja que a nivell local és la variació funcional qui acaba essent objecte de la selecció, ens hem disposat a estudiar els possibles senyals de selecció en gens relacionats amb la interacció hoste-patògen. En
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Golconda, Sarah Rajini. "Why is Nature Able to Mold Some Phenotypes More Readily than Others? Investigating the Structure, Function and Evolution of ßeta-2 Tubulin in Drosophila Melanogaster." University of Dayton / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1524837421834622.

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Khisamutdinov, Emil. "Part I Nucleic Acid Site-Selective Binding Studies of Isomers of Dihydrodioxin-Masked Ortho-Quinones as Potential Antitumor Drugs Part II The Role of Non-Watson-Crick Base Pairs in Stabilizing Recurrent RNA Motif." Bowling Green State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1339432575.

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Books on the topic "Stabilizing selection"

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Shmalʹgauzen, I. I. Factors of evolution: The theory of stabilizing selection. University of Chicago Press, 1986.

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Shmal'gauzen, Ivan Ivanovich. Factors of evolution: The theory of stabilizing selection. University of Chicago Press, 1987.

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Grigorievich, Dobzhansky Theodosius, and I. I. Shmalʹgauzen. Factors of Evolution: The Theory of Stabilizing Selection. Univ of Chicago Pr (Tx), 1987.

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Walsh, Bruce, and Michael Lynch. The Population Genetics of Selection. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198830870.003.0005.

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This chapter examines models of one- and two-locus selection in the absence of drift and mutation. Expressions for the per-generation rate of allele-frequency change and the expected time for a specified amount of change are developed for single-locus models, and their equilibrium structure is examined for those settings where selection retains more than one allele. The presence of selection-generated linkage disequilibrium greatly complicates the extension of single-locus results to two loci, and the chapter examines some of the resulting complications. Finally, it examines the nature of sele
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Walsh, Bruce, and Michael Lynch. Maintenance of Quantitative Genetic Variation. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198830870.003.0028.

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One of the major unresolved issues in quantitative genetics is what accounts for the amount of standing genetic variation in traits. A wide range of models, all reviewed in this chapter, have been proposed, but none fit the data, either giving too much variation or too little apparent stabilizing selection.
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Walsh, Bruce, and Michael Lynch. The Neutral Divergence of Quantitative Traits. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198830870.003.0012.

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The joint action of genetic drift and mutation results in the divergence of trait means over time. This chapter examines the expected amount of divergence, which forms the basis for a number of tests on whether an observed pattern is either too large relative to drift (suggesting directional selection) or two small (suggesting stabilizing selection). It then applies these results to examine tests for selection over a very diverse range of data sets, ranging from a stratophenetic series of fossils to divergence in gene expression over time. It also examines a number of trait-augmented marked-ba
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Walsh, Bruce, and Michael Lynch. Short-term Changes in the Variance: 1. Changes in the Additive Variance. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198830870.003.0016.

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Selection changes the additive-genetic variance (and hence the response in the mean) by both changing allele frequencies and by generating correlations among alleles at different loci (linkage disequilibrium). Such selection-induced correlations can be generated even between unlinked loci, and (generally) are negative, such that alleles increasing trait values tend to become increasingly negative correlated under direction or stabilizing selection, and positively correlated under disruptive selection. Such changes in the additive-genetic variance from disequilibrium is called the Bulmer effect
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Troisi, Alfonso. Diversity. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199393404.003.0010.

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From the perspective of evolutionary biology, diversity is an intrinsic feature of any living species and a target on which natural selection can act in opposite ways: either decreasing it (stabilizing selection) or increasing it (diversifying selection). This duality is reflected in our emotional attitude toward diversity. This chapter summarizes current knowledge on the evolutionary origins of emotional reactions to physical and behavioral diversity in human cultures. After a preliminary discussion of “alternative strategies” observed by ethologists in primate species, the chapter explores t
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Jani, Suni, Ryan Herringa, and Derek Hursey. Pharmacologic Treatment of Children with Trauma- and Stressor-Related Disorders. Edited by Frederick J. Stoddard, David M. Benedek, Mohammed R. Milad, and Robert J. Ursano. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190457136.003.0023.

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This chapter reviews the principles of psychopharmacological treatment for trauma and stressor-related disorders in children. It will discuss emerging psychopharmacological treatments and theories of trauma- and stress-related disorders (TSRDs) common to childhood, reactive attachment disorder, and disinhibited social engagement disorder. Although there is limited literature on the role of pharmacotherapy in treating TSRDs in children, it has been recognized that α‎- and β‎-adrenergic blocking agents, novel antipsychotic agents, non-selective serotonin reuptake inhibitor antidepressants such a
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Butz, Martin V., and Esther F. Kutter. Decision Making, Control, and Concept Formation. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780198739692.003.0012.

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While attention controls the internal, mental focus of attention, motor control directs the bodily control focus. Our nervous system is structured in a cascade of interactive control loops, where the primary self-stabilizing control loops can be found directly in the body’s morphology and the muscles themselves. The hierarchical structure enables flexible and selective motor control and the invocation of motor primitives and motor complexes. The learning of motor primitives and complexes again adheres to certain computational systematicities. Redundant behavioral alternatives are encoded in an
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Book chapters on the topic "Stabilizing selection"

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Stamos, Daniel B. "Stabilizing Selection." In Encyclopedia of Animal Cognition and Behavior. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-319-55065-7_172.

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Stamos, Daniel B. "Stabilizing Selection." In Encyclopedia of Animal Cognition and Behavior. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47829-6_172-1.

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Kanazawa, Yasushi, and Kenichi Kanatani. "Stabilizing Image Mosaicing by Model Selection." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/3-540-45296-6_3.

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Welfens, Paul J. J., and Evgeny Gavrilenkov. "Selection of Links and Internet Pages of Research Institutions Related to Russia." In Restructuring, Stabilizing and Modernizing the New Russia. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57257-9_26.

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O’Meara, Brian C., and Jeremy M. Beaulieu. "Modelling Stabilizing Selection: The Attraction of Ornstein–Uhlenbeck Models." In Modern Phylogenetic Comparative Methods and Their Application in Evolutionary Biology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-43550-2_15.

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Jubran, Oday, and Oliver Theel. "A Self-stabilizing PIF Algorithm for Educated Unique Process Selection." In Networked Systems. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-26850-7_36.

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Soares, Cleide M. F., Heizir F. De Castro, M. Helena A. Santana, and Gisella M. Zanin. "Selection of Stabilizing Additive for Lipase Immobilization on Controlled Pore Silica by Factorial Design." In Twenty-Second Symposium on Biotechnology for Fuels and Chemicals. Humana Press, 2001. http://dx.doi.org/10.1007/978-1-4612-0217-2_59.

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Pesterev, Alexander, and Yury Morozov. "Optimal Selection of Feedback Coefficients in the Problem of Stabilizing a Chain of Three Integrators." In Lecture Notes in Computer Science. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-79119-2_11.

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"Stabilizing Selection." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_16103.

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"Directional Selection, Stabilizing Selection, and Random Drift." In Rates of Evolution. Cambridge University Press, 2019. http://dx.doi.org/10.1017/9781316711644.007.

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Conference papers on the topic "Stabilizing selection"

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Mahajanam, Sudhakar P. V., Dale R. McIntyre, and Larry K. Hovey. "Residual Stress Control for Prevention of Environmental Cracking of Stainless Steels." In CORROSION 2009. NACE International, 2009. https://doi.org/10.5006/c2009-09299.

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Abstract Requirements for residual stress control to prevent anodic stress-corrosion cracking and hydrogen-induced sulfide stress cracking may significantly affect the delivery/lead time and materials selection for heat exchangers. This study reports microhardness, residual stress and environmental cracking test results for duplex stainless steels and austenitic stainless steels with residual stresses from heat exchanger fabrication operations including high surface area tube forming and hair-pin bend formation. The ASTM E837, ASTM G36 and NACE TM0177 methods are used to judge the risk of the
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Crolet, J. L., and M. R. Bonis. "An Optimized Procedure for Corrosion Testing under CO2 and H2S Gas Pressure." In CORROSION 1989. NACE International, 1989. https://doi.org/10.5006/c1989-89017.

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Abstract Before undertaking any laboratory test designed to simulate corrosion in CO2 or H2S-containing waters, it is absolutely essential to fully understand, not only the chemistry of the natural corrosive medium, but also that of the synthetic solutions which are to be reconstituted in an autoclave or test loop, particularly since the composition of the latter gradually changes, and can often even attain the point where they become saturated in iron salts. To this end, a computer calculation program, designated CORMED (or MICO in French), has been developed, which, for any set of conditions
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Tombaugh, Raymond S., and George V. Spires. "The Role of Coating Type Linings in Upgrading/Restoring Power Plant Service Water System Reliability." In CORROSION 1990. NACE International, 1990. https://doi.org/10.5006/c1990-90466.

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Abstract When properly applied, liquid-applied organic coating materials offer an important tool in the arsenal of available technologies for stabilizing and even rehabilitating Power Plant Service Water Systems (SWS’s) that have experienced the deteriorating effects of corrosion, erosion, and fouling. Traditionally, use of coating-type linings has been limited, largely because conventional materials had not proven sufficiently reliable in comparable service, such as circulating water systems. Some SWS linings may be considered safety-related by the definition that debris, which could occur sh
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Xin Wang and Qilian Liang. "Stabilizing the power supply in microgrid using sensor selection." In GLOBECOM 2012 - 2012 IEEE Global Communications Conference. IEEE, 2012. http://dx.doi.org/10.1109/glocom.2012.6503659.

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Ding, Yihua, James Z. Wang, and Pradip K. Srimani. "Self-Stabilizing Selection of Influential Users in Social Networks." In 2014 IEEE 17th International Conference on Computational Science and Engineering (CSE). IEEE, 2014. http://dx.doi.org/10.1109/cse.2014.288.

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Cavallo, Alberto, Giuseppe De Maria, Ciro Natale, and Salvatore Pirozzi. "On scaling matrices optimal selection for H2 strongly stabilizing bandpass controllers." In 2007 46th IEEE Conference on Decision and Control. IEEE, 2007. http://dx.doi.org/10.1109/cdc.2007.4434279.

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McDonald, Karen A., Michael J. Cooney, and Richard S. Criddle. "Manipulative Variable Selection for Stabilizing Control of a Competitive Mixed Culture." In 1988 American Control Conference. IEEE, 1988. http://dx.doi.org/10.23919/acc.1988.4789885.

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Yoon, Changwoo, Xiongfei Wang, Claus Leth Bak, and Frede Blaabjerg. "Site selection of active damper for stabilizing power electronics based power distribution system." In 2015 IEEE 6th International Symposium on Power Electronics for Distributed Generation Systems (PEDG). IEEE, 2015. http://dx.doi.org/10.1109/pedg.2015.7223025.

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Ye Yuan, Lin Cheng, Yuanzhang Sun, and Guojie Li. "Placement of SVCs and selection of stabilizing signals based on observability and controllability." In Energy Society General Meeting. IEEE, 2008. http://dx.doi.org/10.1109/pes.2008.4596608.

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Iarovikov, A. S., S. A. Ishchuk, and V. I. Shmurak. "DOE-BASED APPROACH TO ACCELERATE THE SELECTION OF STABILIZING ADDITIVES FOR PROTEIN SOLUTIONS." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-155.

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The paper describes an approach based on DOE, which makes it possible to speed up the process of selecting additives and their optimal concentrations for the stabilization of protein molecules in solution. The response for the model was the melting temperature, which measured by DSF method. According to the results of the experiments, it was possible to choose a composition that provides an increase in the melting temperature of the fc-fusion protein by 5 °С.
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Reports on the topic "Stabilizing selection"

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García, Salomón. The amplification effects of adverse selection in mortgage credit suply. Banco de España, 2023. http://dx.doi.org/10.53479/30138.

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This paper studies how information frictions in the securitization market amplify the response of mortgage credit supply to house price shocks. We model securitization as an optimal contracting problem between investors and banks. Banks are better informed than investors about the quality of the mortgages they originate, leading to an adverse selection problem. Investors use the quantity sold as a screening device to induce banks to reveal truthful information. We find that adverse selection amplifies the response of a bank’s mortgage originations to house price shocks. The degree of amplifica
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Wang, Han, Issam Qamhia, Erol Tutumluer, and Youngdae Kim. Effectiveness of Geosynthetics in Soil/Aggregate Stabilization—Evaluation Using Bender Element Sensor Technology. Illinois Center for Transportation, 2025. https://doi.org/10.36501/0197-9191/25-007.

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This report presents laboratory evaluations of the effectiveness of geosynthetics in stabilizing unbound aggregate layers and develops design guidelines for using geosynthetic-stabilized pavements in Illinois. The research focused on quantifying benefits from geosynthetic mechanical stabilization and incorporating those benefits into pavement analysis and design procedures. An experimental program was conducted, including laboratory triaxial testing and large-scale test bed evaluations. Twelve geosynthetic products, including ten geogrids (integral or punched and drawn, welded, and woven) and
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