Relevant bibliographies by topics / Stambomycine

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'Stambomycine'

Author: Grafiati
Published: 8 June 2024
Last updated: 31 July 2025

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Journal articles on the topic "Stambomycine"

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Wang, Yongchen, Venkaiah Chintalapudi, Haraldur G. Gudmundsson, Gregory L. Challis, and Edward A. Anderson. "Synthesis of the C50 diastereomers of the C33–C51 fragment of stambomycin D." Organic Chemistry Frontiers 9, no. 2 (2022): 445–49. http://dx.doi.org/10.1039/d1qo01635k.

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The preparation of two C50 diastereomers of the C33–C51 region of stambomycin D is described. In addition to excellent correlation with the natural product, this synthesis establishes conditions for eventual global deprotection.
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Song, Lijiang, Luisa Laureti, Christophe Corre, Pierre Leblond, Bertrand Aigle, and Gregory L. Challis. "Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis." Journal of Antibiotics 67, no. 1 (2013): 71–76. http://dx.doi.org/10.1038/ja.2013.119.

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Su, Li, Laurence Hôtel, Cédric Paris, et al. "Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins." Nature Communications 13, no. 1 (2022). http://dx.doi.org/10.1038/s41467-022-27955-z.

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AbstractThe modular organization of the type I polyketide synthases (PKSs) would seem propitious for rational engineering of desirable analogous. However, despite decades of efforts, such experiments remain largely inefficient. Here, we combine multiple, state-of-the-art approaches to reprogram the stambomycin PKS by deleting seven internal modules. One system produces the target 37-membered mini-stambomycin metabolites − a reduction in chain length of 14 carbons relative to the 51-membered parental compounds − but also substantial quantities of shunt metabolites. Our data also support an unpr
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Su, Li, Laurence Hôtel, Cédric Paris, et al. "Author Correction: Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins." Nature Communications 13, no. 1 (2022). http://dx.doi.org/10.1038/s41467-022-33524-1.

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5

Su, Li, Yaouba Souaibou, Laurence Hôtel, et al. "Correction: Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues." Chemical Science, 2025. https://doi.org/10.1039/d5sc90046h.

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Correction for ‘Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues’ by Li Su et al., Chem. Sci., 2025, https://doi.org/10.1039/d4sc06976e.
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6

Kalhor, Hourieh, Mohammad Hossein Mokhtarian, Hamzeh Rahimi, et al. "Predictive Insights Into Bioactive Compounds from Streptomyces as Inhibitors of SARS-CoV-2 Mutant Strains by Receptor Binding Domain: Molecular Docking and Dynamics Simulation Approaches." Iranian Journal of Pharmaceutical Research 23, no. 1 (2024). https://doi.org/10.5812/ijpr-150879.

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Background: The receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 interacts with the angiotensin-converting enzyme 2 (ACE2) receptor in humans. To date, numerous SARS-CoV-2 variants, particularly those involving mutations in the RBD, have been identified. These variants exhibit differences in transmission, pathogenicity, diagnostics, and vaccine efficacy. Objectives: Although therapeutic agents are currently available to inhibit SARS-CoV-2, most provide supportive and symptomatic relief. Moreover, different variants may exhibit resistance to these treatments. This study aimed to
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7

Lim, Jieyan, Venkaiah Chintalapudi, Haraldur G. Gudmundsson, et al. "Synthesis of the C1–C27 Fragment of Stambomycin D Validates Modular Polyketide Synthase-Based Stereochemical Assignments." Organic Letters, September 8, 2021. http://dx.doi.org/10.1021/acs.orglett.1c02650.

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8

SU, Li, Yaouba Souaibou, Laurence Hôtel, et al. "Exploiting the inherent promiscuity of the acyl transferase of the stambomycin polyketide synthase for the mutasynthesis of analogues." Chemical Science, 2025. https://doi.org/10.1039/d4sc06976e.

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The polyketide specialized metabolites of bacteria are attractive targets for generating analogues, with the goal of improving their pharmaceutical properties. Here, we aimed to produce C-26 derivatives of the giant...
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Dissertations / Theses on the topic "Stambomycine"

1

Su, Li. "Generation of analogues of the anti-tumor polyketide stambomycins by genetic engineering and allied approaches." Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0081.

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Les polycétides d’origine bactérienne sont une source importante de molécules anti-infectieuses et anticancéreuses d’origine naturelle utilisées en thérapie. Cependant, leurs structures doivent souvent être optimisées afin d'améliorer leurs propriétés thérapeutiques. Les stambomycines, une famille de macrolides parmi les plus grands polycétides connus (elles possèdent un noyau macrolactone à 51 membres), ont été récemment découvertes par une approche de genome mining chez la bactérie Streptomyces ambofaciens ATCC23877. Ces molécules présentent une activité anticancéreuse prometteuse. Six forme
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