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Relevant bibliographies by topics / Staphylococcal protein A (SpA)

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Academic literature on the topic 'Staphylococcal protein A (SpA)'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Staphylococcal protein A (SpA)"

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Kim, Hwan Keun, Alice G. Cheng, Hye-Young Kim, Dominique M. Missiakas, and Olaf Schneewind. "Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in mice." Journal of Experimental Medicine 207, no. 9 (2010): 1863–70. http://dx.doi.org/10.1084/jem.20092514.

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The current epidemic of hospital- and community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections has caused significant human morbidity, but a protective vaccine is not yet available. Prior infection with S. aureus is not associated with protective immunity. This phenomenon involves staphylococcal protein A (SpA), an S. aureus surface molecule that binds to Fcγ of immunoglobulin (Ig) and to the Fab portion of VH3-type B cell receptors, thereby interfering with opsonophagocytic clearance of the pathogen and ablating adaptive immune responses. We show that mutation of each

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Deis, Lindsay N., Qinglin Wu, You Wang, et al. "Suppression of conformational heterogeneity at a protein–protein interface." Proceedings of the National Academy of Sciences 112, no. 29 (2015): 9028–33. http://dx.doi.org/10.1073/pnas.1424724112.

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Staphylococcal protein A (SpA) is an important virulence factor from Staphylococcus aureus responsible for the bacterium’s evasion of the host immune system. SpA includes five small three-helix–bundle domains that can each bind with high affinity to many host proteins such as antibodies. The interaction between a SpA domain and the Fc fragment of IgG was partially elucidated previously in the crystal structure 1FC2. Although informative, the previous structure was not properly folded and left many substantial questions unanswered, such as a detailed description of the tertiary structure of SpA

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Kim, Hwan Keun, Fabiana Falugi, Dominique Missiakas, and Olaf Schneewind. "Expression of two immunoglobulin binding proteins is necessary for S. aureus to avoid host mediated innate and adaptive immune systems (P3138)." Journal of Immunology 190, no. 1_Supplement (2013): 186.16. http://dx.doi.org/10.4049/jimmunol.190.supp.186.16.

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Abstract Human or animal infections with S. aureus do not elicit protective immunity against staphylococcal diseases. Staphylococci are notorious to deploy a wide spectrum of strategies to avoid host immune system. Previous work revealed that both innate and adaptive immune systems are hampered by the expression of two immunoglobulin binding proteins; staphylococcal protein A (SpA) and staphylococcal binder of immunoglobulins (Sbi). Staphylococcal protein A, a molecule that associates with both Fc and Fab portions of immunoglobulins, is necessary 1) to neutralize the antibody mediated opsonoph

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Wei, Yuannan, Esha Sandhu, Xi Yang, Jie Yang, Yuanyuan Ren, and Xingjie Gao. "Bidirectional Functional Effects of Staphylococcus on Carcinogenesis." Microorganisms 10, no. 12 (2022): 2353. http://dx.doi.org/10.3390/microorganisms10122353.

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As a Gram-positive cocci existing in nature, Staphylococcus has a variety of species, such as Staphylococcus aureus and Staphylococcus epidermidis, etc. Growing evidence reveals that Staphylococcus is closely related to the occurrence and development of various cancers. On the one hand, cancer patients are more likely to suffer from bacterial infection and antibiotic-resistant strain infection compared to healthy controls. On the other hand, there exists an association between staphylococcal infection and carcinogenesis. Staphylococcus often plays a pathogenic role and evades the host immune s

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Sasso, E. H., G. J. Silverman, and M. Mannik. "Human IgM molecules that bind staphylococcal protein A contain VHIII H chains." Journal of Immunology 142, no. 8 (1989): 2778–83. http://dx.doi.org/10.4049/jimmunol.142.8.2778.

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Abstract Staphylococcal protein A (SPA) is a bacterial membrane protein which has distinct binding sites for Fc gamma and for the Fab region of some IgM, IgG, IgA, and IgE molecules. This study establishes a structure-function correlation responsible for the binding of Ig Fab regions to SPA. Binding of 24 isolated human monoclonal IgM proteins to SPA was measured in a solid phase RIA. VH and V kappa subgroups of each IgM were determined by SDS-PAGE, transfer blotting, and detection with antisera prepared against specific first framework region peptides. Binding to SPA was seen with 10 of 11 VH

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Das, C., and J. J. Langone. "Dissociation between murine spleen cell mitogenic activity of enterotoxin contaminants and anti-tumor activity of staphylococcal protein A." Journal of Immunology 142, no. 8 (1989): 2943–48. http://dx.doi.org/10.4049/jimmunol.142.8.2943.

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Abstract Soluble staphylococcal protein A (SpA) in the form of high m.w. complexes with IgG has been shown to significantly inhibit the growth of Meth A fibrosarcomas in BALB/c mice. Although SpA reportedly is a potent T cell mitogen that can induce immune cell proliferation and production of humoral factors with anti-tumor activity, it has been suggested that mitogenic enterotoxin contaminants might be responsible for these effects. The purpose of the present study was to investigate the nature of SpA-induced cell proliferation and the relationship between mitogenicity and the anti-tumor effe

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Kim, Hwan Keun, Fabiana Falugi, Dominique M. Missiakas, and Olaf Schneewind. "Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion duringStaphylococcus aureusinfection." Proceedings of the National Academy of Sciences 113, no. 20 (2016): 5718–23. http://dx.doi.org/10.1073/pnas.1524267113.

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A hallmark ofStaphylococcus aureusdisease in humans is persistent infections without development of protective immune responses. Infected patients generate VH3 plasmablast expansions and increased VH3 idiotype Ig; however, the mechanisms for staphylococcal modification of immune responses are not known. We report here thatS. aureus-infected mice generate VH3 antibody expansions via a mechanism requiring MHC-restricted antigen presentation to CD4+T cells and staphylococcal protein A (SpA), a cell wall-anchored surface molecule that binds Fcγ and VH3 variant heavy chains of Ig. VH3 expansion occ

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Fomina, Lyudmila O., Victor A. Gritsenko та Anastasia I. Fayzullina. "Сomparative analysis of cytokine determination in neutrophil supernatants stimulated by S. aureus supernatants with and without the SPA gene". Journal of Ural Medical Academic Science 19, № 3 (2022): 273–81. http://dx.doi.org/10.22138/2500-0918-2022-19-3-273-281.

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This study presents the results of the determination of cytokines by multiplex analysis in the blood neutrophil supernatants of donors stimulated by Staphylococcus aureus supernatants, depending on the presence or absence of the staphylococcal protein A (spa) gene in bacteria. Cytokine indication was carried out by multiplex analysis using BioRad kits (USA) for the determination of 17 human cytokines (G-CSF, GM-CSF, INF-γ, TNF-alfa, MCP-1, MIP-1beta, IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-7,IL-8, IL-10, IL-12p70, IL-13, IL-17A) after 1 hour incubation of staphylococcal supernatants with neutroph

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Roben, P. W., A. N. Salem, and G. J. Silverman. "VH3 family antibodies bind domain D of staphylococcal protein A." Journal of Immunology 154, no. 12 (1995): 6437–45. http://dx.doi.org/10.4049/jimmunol.154.12.6437.

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Abstract Staphylococcal protein A (SpA) is a 45-kDa bacterial membrane protein that can interact with either Fc gamma, a constant region portion of IgG, or with the Fab portion that also mediates conventional Ag binding. In recent reports, SpA has been shown to specifically interact with Fab derived from the VH3 family and is little affected by VH CDR3, JH, or light chain usage. To identify a site on SpA responsible for VH3 Fab binding, we cloned and expressed in Escherichia coli the 61 amino acid sequence of SpA that represents domain D, and this small protein exhibited both the VH3 Fab and F

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Cruz, Ana Rita, Maurits A. den Boer, Jürgen Strasser, et al. "Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation." Proceedings of the National Academy of Sciences 118, no. 7 (2021): e2016772118. http://dx.doi.org/10.1073/pnas.2016772118.

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Immunoglobulin (Ig) G molecules are essential players in the human immune response against bacterial infections. An important effector of IgG-dependent immunity is the induction of complement activation, a reaction that triggers a variety of responses that help kill bacteria. Antibody-dependent complement activation is promoted by the organization of target-bound IgGs into hexamers that are held together via noncovalent Fc-Fc interactions. Here we show that staphylococcal protein A (SpA), an important virulence factor and vaccine candidate of Staphylococcus aureus, effectively blocks IgG hexam

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Dissertations / Theses on the topic "Staphylococcal protein A (SpA)"

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Osei, Awuku Kwabena. "Superantigen-like interaction of IVIG with antibody Fab fragments cloned by phage display technology." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96462785X.

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Gao, Jinxin. "Regulatory elements in the Staphylococcus aureus protein A (Spa) gene promoter and characterization of SarS binding to the Spa promoter /." Search for this dissertation online, 2004. http://wwwlib.umi.com/cr/ksu/main.

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Roberts, Jill Carolyne. "Characterization of Community-acquired Methicillin-resistant Staphylococcus aureus by Pulsed-field Gel Electrophoresis, Multilocus Sequence Typing, and Staphylococcal Protein A Sequencing: Establishing a Strain Typing Database." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001489.

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Sauerwald, Claudia. "Die subklinische Staphylococcus aureus-Mastitis - Sanierung eines hessischen Milcherzeugerbetriebes und epidemiologische Untersuchungen mittels Staphylokokken-Protein A (spa)-Typisierung." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-127925.

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In der vorliegenden Studie wurde die Sanierung einer durch S. aureus verursachten Eutergesundheitsstörung in einem hessischen Milchviehbestand mittels klassischer Sanierungsmaßnahmen über einen Zeitraum von 18 Monaten begleitet. Durch konsequente Einhaltung der Sanierungsmaßnahmen nach dem Fünf-Punkte-Plan und die räumliche Trennung der Herde in eine S. aureus-positive und -negative Gruppe sank die S. aureus-Prävalenz im Betrieb innerhalb von 15 Monaten von 30% auf <1%. Nach 18 Monaten waren erstmalig keine Neuinfektionen mehr mit S. aureus zu verzeichnen. Zusätzlich zu den im Abstand von dre

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Stephens, Alex J. "The development of rapid genotyping methods for methicillin-resistant Staphylococcus aureus." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/20172/1/Alexander_Stephens_Thesis.pdf.

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Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen that is endemic in hospitals all over the world. It has more recently emerged as a serious threat to the general public in the form of community-acquired MRSA. MRSA has been implicated in a wide variety of diseases, ranging from skin infections and food poisoning to more severe and potentially fatal conditions, including; endocarditis, septicaemia and necrotising pneumonia. Treatment of MRSA disease is complicated and can be unsuccessful due to the bacterium's remarkable ability to develop antibiotic resistance.

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Stephens, Alex J. "The development of rapid genotyping methods for methicillin-resistant Staphylococcus aureus." Queensland University of Technology, 2008. http://eprints.qut.edu.au/20172/.

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Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen that is endemic in hospitals all over the world. It has more recently emerged as a serious threat to the general public in the form of community-acquired MRSA. MRSA has been implicated in a wide variety of diseases, ranging from skin infections and food poisoning to more severe and potentially fatal conditions, including; endocarditis, septicaemia and necrotising pneumonia. Treatment of MRSA disease is complicated and can be unsuccessful due to the bacterium's remarkable ability to develop antibiotic resistance.

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Sauerwald, Claudia [Verfasser], Axel [Akademischer Betreuer] Sobiraj, and Axel [Gutachter] Sobiraj. "Die subklinische Staphylococcus aureus-Mastitis - Sanierung eines hessischen Milcherzeugerbetriebes und epidemiologische Untersuchungen mittels Staphylokokken-Protein A (spa)-Typisierung / Claudia Sauerwald ; Gutachter: Axel Sobiraj ; Betreuer: Axel Sobiraj." Leipzig : Universitätsbibliothek Leipzig, 2013. http://d-nb.info/123852754X/34.

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Taylor, M. J. "Protein engineering of staphylococcal protein A." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373965.

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Löfblom, John. "Staphylococcal surface display for protein engineering and characterization." Doctoral thesis, KTH, Skolan för bioteknologi (BIO), 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4584.

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Even though our understanding of mechanisms such as protein folding and molecular recognition is relatively poor, antibodies and alternative affinity proteins with entirely novel functions are today generated in a routine manner. The reason for this success is an engineering approach generally known as directed evolution. Directed evolution has provided researchers with a tool for circumventing our limited knowledge and hence the possibility to create novel molecules that by no means could have been designed today. The approach is based on construction of high-complexity combinatorial librarie

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Löfblom, John. "Staphylococcal surface display for protein engineering and characterization /." Stockholm : Bioteknologi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4584.

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Books on the topic "Staphylococcal protein A (SpA)"

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Susan, Grodnick, ed. The Four Seasons Spa Cuisine. Simon and Schuster, 1986.

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Herrington, William G., Aron Chakera, and Christopher A. O’Callaghan. Urinary tract infection. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0158.

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A urinary tract infection (UTI) is defined as present when urine culture results in the growth of a single organism at greater than 105 colony-forming units/ml of urine. Bowel flora are the commonest cause of UTIs. Escherichia coli accounts for 80% of infections. Klebsiella spp., Proteus mirabilis, Enterococcus faecalis, and Staphylococcal saprophyticus account for most of the remaining 20%. Staphylcoccus aureus culture is usually catheter related or secondary to haematogenous spread. This chapter looks at the symptoms of a UTI, as well as its demographics, complications, diagnosis (including

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Book chapters on the topic "Staphylococcal protein A (SpA)"

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Bhakdi, S., I. Walev, M. Palmer, and A. Valeva. "Staphylococcal α Toxin." In Bacterial Protein Toxins. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-05971-5_22.

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Bhakdi, Sucharit, Iwan Walev, Matthias Husmann, and Angela Valeva. "Staphylococcal alpha-toxin." In Microbial Protein Toxins. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/b100513.

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Swaminathan, S., William Furey, and Martin Sax. "Structure of Staphylococcal Enterotoxins." In Protein Toxin Structure. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-662-22352-9_12.

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Schlievert, Patrick M. "Staphylococcal and Streptococcal Superantigens." In Bacterial Protein Toxins. ASM Press, 2014. http://dx.doi.org/10.1128/9781555817893.ch21.

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Schneewind, Olaf, and Dominique M. Missiakas. "Staphylococcal Protein Secretion and Envelope Assembly." In Gram-Positive Pathogens. ASM Press, 2019. http://dx.doi.org/10.1128/9781683670131.ch37.

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Aslıyüce, Sevgi, Bo Mattiasson, and Adil Denizli. "Preparation of Staphylococcal Protein A Imprinted Supermacroporous Cryogel Beads." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2176-9_18.

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Frenz, Christopher M. "Protein Stability Engineering in Staphylococcal Nuclease Using an AI-Neural Network Hybrid System and a Genetic Algorithm." In Advances in Applied Artificial Intelligence. Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/11779568_100.

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Jardetzky, Oleg. "Nuclear Magnetic Resonance Studies of Protein Binding Sites: The Complex of Staphylococcal Nuclease with 3′,5′-Thymidine Diphosphate." In Ciba Foundation Symposium - Molecular Properties of Drug Receptors. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470719763.ch7.

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MacKintosh, F. Roy, Kim Bennett, and Stephen W. Hall. "Trials of Staphylococcal Protein A-Treated Plasma Infusions in Cancer Therapy: Clinical Effects and Implications for Mode of Action." In Immune Complexes and Human Cancer. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-4931-0_7.

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Thasiro, M., R. Tejero, D. E. Zimmerman, B. Celda, B. Nilsson, and G. T. Montelione. "High Resolution Solution NMR Structure of the Z Domain of Staphylococcal Protein A. Analysis of Secondary Structure for Free Z Domain and Bounded to IgG Antibody." In Spectroscopy of Biological Molecules: Modern Trends. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5622-6_14.

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Conference papers on the topic "Staphylococcal protein A (SpA)"

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Teitel, J. M., A. Shore, and J. McBarron. "REGULATION OF INTERLEUKIN-2 (IL-2) PRODUCTION BY ENDOTHELIAL CELL (EC) DERIVED SUBSTANCES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642865.

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We recently reported that vascular EC support the staphylococcal protein A (SPA)-induced production of IL-2 by T cells, and furthermore do so synergistically with monocytes. We have now assessed the contributions of EC membrane-associated and secreted factors to these functions. IL-2 was measured by either human tonsil blast of CTLL cell assay. Separation of EC from T cells by a permeable membrane (.45μ pore size) prevented IL-2 production. Consistent with this, supernatant from resting EC (ECs) was also unable to induce IL-2 generation. In addition, neither a crude EC plasma membrane preparat

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Luo, Binbin, Wengen Zou, Shenghui Shi, et al. "Modified technique for the fiber surface using Staphylococcal protein A." In Asia-Pacific Optical Sensors Conference. OSA, 2016. http://dx.doi.org/10.1364/apos.2016.w4a.35.

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Tomita, Noriko, Kazuyo Abe, and Makoto Ohta. "Quantitative Analysis of Subunit Mismatch Arrangement in Staphylococcal Gamma-Hemolysin Heteroheptameric Transmembrane Pore." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-63645.

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Pore-forming cytolytic proteins distributed in a wide variety of eukaryotic and prokaryotic organisms have been intensively studied in terms of pathophysiological functions and molecular architecture of transmembrane pores. These proteins are also being developed for various analytical applications such as detector of proteins and DNA by engineering the structure of the pore. Staphylococcal gamma-hemolysin (Hlg), a pore-forming protein, which consists of two separate proteins, LukF and Hlg2, has potential to be a useful tool as a multifunctional biosensor. However, the fine structure of the Hl

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Sun, Jizhou, Chao Bian, Qu Lan, and Shanhong Xia. "A micro amperometric immunosensor immobilized with electropolymerized staphylococcal protein a for the detection of salmonella typhimurium." In 2009 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2009). IEEE, 2009. http://dx.doi.org/10.1109/nems.2009.5068581.

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Santhekadur, Prasanna K., Rachel Gredler, Maaged Akiel, Paul Dent, Paul B. Fisher та Devanand Sarkar. "Abstract 2628: The multifunctional protein staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion of hepatocellular carcinoma (HCC) cells by modulating angiotensin II type 1 receptor (AT1R) and transforming growth factor-β (TGF-β) s". У Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2628.

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Komsalova, L. Y., A. Valdivia, and P. M. Salinas. "AB0871 Predictive values of inflammatory low back pain, positive hla b 27 antigen, increased c reactive protein, postive magnetic resonance and other features in axial spondiloarthritis (SPA). a prospective 2 years follow up." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.1345.

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Koedam, Joost A., Rob J. Hamer, Nel H. Beeser-Visser, Etienne Jap Tjoen San, Kees Schippers, and Jan J. Sixma. "THE INTERACTION BETWEEN FACTOR VIII AND VON WILLEBRAND FACTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644771.

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Factor VIII (FVIII) circulates in plasma as a non-covalent complex with von Willebrand factor (VWF), a large multimeric adhesive glycoprotein. VWF serves as a carrier for FVIII and is thought to stabilize FVIII. The interaction between the two proteins was studied by binding purified human 125I-FVIII to VWF which was coated on a solid matrix. Experiments employing isolated heavy and light chains of FVIII and monoclonal antibodies indicated that binding occurred through the carboxyterminal 80kDa light chain of factor VIII. Treatment of VWF-bound 125I-FVIII with thrombin resulted in the release

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Reports on the topic "Staphylococcal protein A (SpA)"

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เร่งพิพัฒน์, ศิริรัตน์, ฐิติพงศ์ ธนะรัชติการนนท์ та ปัญชลี ประคองศิลป์. การใช้แลคติกแอซิดแบคทีเรียเป็นโพรไบโอติกเพื่อเสริมในอาหารไก่ : รายงานการวิจัยฉบับสมบูรณ์. จุฬาลงกรณ์์มหาวิทยาลัย, 1998. https://doi.org/10.58837/chula.res.1998.33.

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การแยกแลคติกแอซิดแบคทีเรียจากลำไส้ไก่ที่มีสุขภาพแข็งแรงจากตลาดสดแหล่งต่างๆ ในกรุงเทพมหานคร จำนวน 54 ตัวอย่าง ได้เชื้อแลคติกแอซิดแบคทีเรีย จำนวนทั้งสิ้น 28 สายพันธุ์ และเมื่อนำมาทดสอบความสามารถในการยับยั้งเชื้อทดสอบ Bordetella avium, Listeria monocytogenes, Pasteurella multocida, Proteus vugalis, Pseudomonas aeruginose, Salmonella enteritidis, Salmonella typhimurium และ Staphylococcus aureus พบว่าส่วนน้ำเลี้ยงเชื้อของแลคติกแอซิดแบคทีเรียจำนวน 6 สายพันธุ์ สามารถยับยั้งเชื้อทดสอบบนอาหารเลี้ยงเชื้อแข็ง โดยดูความกว้างของบริเวณยับยั้ง และเมื่อนำเชื้อทั้ง 6 สายพันธุ์ มาทำการจัดกลุ่มตามหลักอนุกรมวิธาน

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จันทร์ฉายทอง, ภัทรรัฐ, นัทธี อ่ำอินทร์, เผด็จ ธรรมรักษ์ та ณุวีร์ ประภัสระกูล. การกระจาย การจำแนกชนิดเชิงโมเลกุลและความไวรับต่อยาต้านจุลชีพของเชื้อ methicillin-resistant Staphylococcus aureus ในการผลิตสุกรและผู้เลี้ยงสุกรในเขตภาคกลางของประเทศไทย : รายงานวิจัยฉบับสมบูรณ์. คณะสัตวแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2018. https://doi.org/10.58837/chula.res.2018.86.

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การศึกษานี้มีวัตถุประสงค์เพื่อหาการกระจาย คุณลักษณะทางพันธุกรรมและความไวรับต่อยาต้านจุลชีพของเชื้อ methicillin-resistant Staphylococcus aureus (MRSA) ที่พบในสุกรและผู้เลี้ยงสุกรในเขตภาคกลางของประเทศไทย ผลการศึกษาพบความชุกเชื้อ MRSA รอยละ 9.72 (59 จาก 607 ตัวอย่าง) จากตัวอย่างจากเยื่อบุช่องจมูกสุกร พบความชุกฝูงร้อยละ 37.02 (10 จาก 27 ฟาร์ม) และพบความชุกในผู้เลี้ยงสุกร ร้อยละ 7.83 (3 จาก 38 คน) เชื้อ MRSA จำนวนทั้งหมด 63 เชื้อมี staphylococcal cassette chromosome mec (SCCmec) V (41 เชื้อ) SCCmec IX (9 เชื้อ) SCCmec composite island ชนิดใหม่ (12 เชื้อ) และ SCCmec ที่จำแนกไม่ได้ (1 เชื้อ) โดย SCCm

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Leitner, Gabriel, and Naomi Balaban. Novel Immunotherapeutic Agent for the Treatment and Prevention of Staphylococcal Mastitis in Dairy Cows. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7709880.bard.

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Staphylococci are the most common and costly mammary disease of dairy cattle worldwide. TRAP, a membrane associated 167AA protein, is highly conserved among staphylococci. The aims of this study were to test the safety and efficacy of recombinant TRAP (rTRAP) vaccine in dairy animals. The vaccine was safe as 2-3 subcutaneous injections of rTRAP (54–100μg) with adjuvant ISA 206 to cows and goats did not lead to any abnormal symptoms of sensitivity to the vaccine. The rTRAP vaccine was immunogenic and caused the induction of a humoral immune response that remained high for at least 160 days post

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Leitner, Gabriel, and Naomi Balaban. Novel Immunotherapeutic Agent for the Treatment and Prevention of Staphylococcal Mastitis in Dairy Cows. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7695866.bard.

Full text

Abstract:

Staphylococci are the most common and costly mammary disease of dairy cattle worldwide. TRAP, a membrane associated 167AA protein, is highly conserved among staphylococci. The aims of this study were to test the safety and efficacy of recombinant TRAP (rTRAP) vaccine in dairy animals. The vaccine was safe as 2-3 subcutaneous injections of rTRAP (54–100μg) with adjuvant ISA 206 to cows and goats did not lead to any abnormal symptoms of sensitivity to the vaccine. The rTRAP vaccine was immunogenic and caused the induction of a humoral immune response that remained high for at least 160 days post

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Sordillo, Lorraine, Don Wojchowski, Gary Perdew, Arthur Saran, and Gabriel Leitner. Identification of Staphylococcus aureaus Virulence Factors Associated with Bovine Mastitis. United States Department of Agriculture, 2001. http://dx.doi.org/10.32747/2001.7574340.bard.

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Staphylococcus aureus is a major cause of mastitis in dairy cattle. The organism is able to adhere to and penetrate mammary epithelium, forming deep seated abscesses that result in chronic infections. This study was based on the observation that certain genotypes of S. aureus are isolated more frequently from field cases of bovine mastitis than others and the most prevalent genotypes of S. aureus have an increased ability to resist neutrophil phagocytosis and killing compared to the rare variants. It was hypothesized that these predominating genotypes differentially express virulence factors t

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