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Books on the topic 'STAT. Inhibitor'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Ward, Alister C., ed. STAT Inhibitors in Cancer. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42949-6.

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2

Fleischmann, Roy. Signalling pathway inhibitors. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0081.

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Oral, small-molecule signalling pathway inhibitors, including ones that inhibit the JAK and SyK pathways, are currently in development for the treatment of rheumatoid arthritis (RA). Tofacitinib is an orally administered small-molecule inhibitor that targets the intracellular Janus kinase 3 and 1 (JAK1/3) molecules to a greater extent than JAK2 while baricitinib (formerly INCB028050) predominantly inhibits JAK1/2. Many of the proinflammatory cytokines implicated in the pathogenesis of RA utilize cell signalling that involves the JAK-STAT pathways and therefore inhibition of JAK-STAT signalling

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Ward, Alister C. STAT Inhibitors in Cancer. Humana, 2016.

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4

Ward, Alister C. STAT Inhibitors in Cancer. Humana, 2018.

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5

Brunner, Hans R. Ace-Inhibition: State of the Art. S Karger Pub, 1989.

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6

(Editor), A. Raman, and Paul Labine (Editor), eds. Reviews on Corrosion Inhibitors Science and Technology: Papers Presented at the Corrosion/89 Symposium "Review of Corrosion Inhibition Science." Sponsored ... Group T-3A-15 N Inhibitors, State-Of-The a. Nace, 1993.

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7

Bernhard, Elsener, European Federation of Corrosion, and Institute of Materials (Great Britain), eds. Corrosion inhibitors for steel in concrete: State of the art report. published for the European Federation of Corrosion by Maney on behalf of the Institute of Materials, 2001.

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8

Martin, Richard. Inhibition of the RTEM-1 [beta]-lactamase by transition-state analogs. 1996.

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9

Young, Benjamin. Classes of Antiretrovirals. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0019.

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Results of the randomized, international INSIGHT START clinical trial provide definitive proof of the benefit of antiretroviral therapy initiation in asymptomatic individuals with CD4+ counts greater than 500 cells/mm3. There are six different classes of antiretroviral agents: two types of reverse transcriptase inhibitors, two types of entry inhibitors, one class of inhibitors of HIV protease, and one class of inhibitors of HIV integrase. Combination antiretroviral therapy is recommended for all people living with HIV. The primary goal of combination antiretroviral therapy is to achieve viral

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Alikhan, Raza. Normal haemostatic function. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0283.

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Humans have evolved an intricate system that maintains blood in a fluid state. This relies on an intact vascular endothelium modulating vascular tone and forming a barrier between blood components and reactive subendothelial components. It also involves the production of inhibitors of both blood coagulation and platelet aggregation. In addition, haemostatic systems are primed to convert blood from its fluid state to a solid state, to allow the formation of a haemostatic plug, following vessel injury, to stem the flow of blood from or within a blood vessel. This chapter reviews the physiology o

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Konstan, David. Hate and the State in Ancient Greece. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190465544.003.0003.

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In classical antiquity, thinkers like Aristotle regarded hatred, unlike envy, as a moral emotion, elicited by the perception of vice. Nevertheless, hatred might be taken to irrational extremes (there are occasional expressions of hatred of all women, for example), and antagonisms between ethnic groups (as in Sparta or Alexandria) or social classes (in many Greek city states) could lead to open conflict or civil war. Classical states had few resources to inhibit or control such hatreds. One significant development in this direction, however, was the amnesty decreed in Athens to heal the wounds

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Schmidt, Susanne K. Reaching Beyond the Market into State Responsibilities. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198717775.003.0005.

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Chapter 5 addresses policies that are more sensitive to sovereignty. The Citizenship Directive and the Patient Mobility Directive were both highly influenced by case-law development, although member states have largely reserved the right to define citizenship and the shape of their welfare states. The Court, however, consistently holds that member states have to respect the four freedoms also in areas of exclusive competence. Neither did existing secondary law inhibit the Court from partly designing an alternative policy. Regulation through case law is susceptible to creating inequalities, as

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Hum, Gabriel. Novel approaches towards the synthesis of protein tyrosine phosphatase inhibitors and alternative strategies in the design of transition state analogues for phosphatase abzymes. 2002.

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14

Lameire, Norbert. Prevention of acute kidney injury. Edited by Norbert Lameire. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0224_update_001.

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The prevention of acute kidney injury (AKI) should start with an assessment of the risk to develop AKI, by identification of co-morbidities, use of potentially nephrotoxic medications, and early recognition of acute reversible risk factors associated with AKI. This chapter discusses first the most relevant general risk factors for AKI and describes the recent introduction of several surveillance systems. In addition, some specific risk factors play a role in the pathogenesis of post-cardiac surgery AKI. Finally risks associated with commonly used drugs such as non-steroidal anti-inflammatory d

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D’Attoma, John. Explaining Italian Tax Compliance. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198796817.003.0005.

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It is well known that tax compliance is low in Italy. Many scholars have examined Italian taxpayer behavior, mainly using experiments and surveys. However, little attention has been given to the historical circumstances that have shaped divergent taxpayer behavior in Italy. This chapter uses historical data from Italian unification through the Second Republic to assess the effects of Italy’s major formal institutions (the Church, state, and political parties) and informal institutions (clientelism) on Italian tax behavior. It argues that nineteenth-century unification and Fascism had significa

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Hartley, Janet. Peter’s Legacy. Edited by Simon Dixon. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199236701.013.009.

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Concentrating on central and local government and on fiscal reform, this chapter argues that although consecutive rulers’ attempts to modernize their state administration were inhibited by the political and social structures they inherited, their efforts were nevertheless sufficiently successful to permit Russia to become the most feared military power in Europe. Paradoxically, this very success militated against root-and-branch change to the system that had served the Tsars so well. Across the century between 1725 and 1825, therefore, Russia continued to adjust its institutional structures wi

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Brace, Paul. Aggregating Survey Data to Estimate Subnational Public Opinion. Edited by Lonna Rae Atkeson and R. Michael Alvarez. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780190213299.013.15.

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Public opinion’s role in shaping governmental actions is a central concern of democracy, yet the absence of systematic state-level survey data has inhibited analyses of public opinion at the subnational level. This essay traces the evolution of studies of public opinion at that level, first reviewing studies using surrogates derived from demographic variables. It next considers methodologies that develop state-level opinion from aggregated national samples. Finally, it discusses recent efforts to develop state-level opinion measures using post-sample stratification integrating limited survey d

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Ritzinger, Justin R. Reawakening Maitreya. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190491161.003.0007.

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The final chapter examines the legacy of the reformist cult of Maitreya in the contemporary period. In the People’s Republic of China, state interests and heavy regulation of religion has accelerated some developments and inhibited others. Xuedou shan has developed rapidly into a large and powerful institution, while a new wave of Maitreya Study Associations in China has faltered. In Taiwan, full liberalization has allowed new organizations to spring up, pursuing novel modes of propagation. These include Daci shan, the Taiwan Maitreya Study Association, and the Bade Maitreya Lodge. The chapter

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19

Bjork, Stephanie R. Clan and Cultural Intimacy. University of Illinois Press, 2018. http://dx.doi.org/10.5406/illinois/9780252040931.003.0001.

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This chapter provides an overview of Somali kinship studies and discusses why such studies have become marginalized within Somali studies. It is argued that cultural intimacy explains the intricacies that shape Somalis’ contestation of clan and the cultural intimacy of clan inhibits scholarship. A practice theory approach to clan is outlined and Bourdieu’s formulation of social capital serves as a foundation for understanding how clan is experienced and employed. The chapter discusses Somalis’ initial movement to Finland as accidental and later movement as a strategy to access benefits of the

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Kenney, Padraic. Conclusion. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199375745.003.0011.

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In an ordinary prison, the goal is to rehabilitate its inmates; in the political prison, the state demonstrates its power to detain, confine, name, and torture or at the very least discomfort and inhibit a group of people who claim to oppose it. Often state leaders learn that they have to negotiate with prisoners and treat them as potential partners. Rendered illegible by the state’s prison, prisoners create their own illegibility and confuse the prison, refusing its terms. As they create communal structures, engage in protest, and invent prison universities, political prisoners create a new n

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21

Kobrin, Sarah C., and Alex Conway. Treatment for Early Stage Prostate Cancer. Edited by David A. Chambers, Wynne E. Norton, and Cynthia A. Vinson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190647421.003.0017.

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Men diagnosed with early stage prostate cancer will very likely survive many years after their prostate cancer treatment, regardless of which standard treatment is used. This case study describes a situation in which all standard treatments are supported by evidence but side effects vary greatly. In this situation, a partnership is needed between the doctor and the patient to choose the best option. This case study gives a brief overview of the complexities of choosing a treatment for early state prostate cancer and how implementation science is needed to (1) consider effectiveness and impleme

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Bresser-Perreira, Luiz Carlos. Brazil’s Macroeconomic Policy Institutions, Quasi-Stagnation, and the Interest Rate–Exchange Rate Trap. Edited by Edmund Amann, Carlos R. Azzoni, and Werner Baer. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190499983.013.10.

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This chapter examines the evolution of macroeconomic policy and institutions over the long term and the ways in which they have influenced the growth path of the Brazilian economy. It establishes that a critical influence on the disappointing growth performance realized was a failure to neutralize the effects of exchange rate induced Dutch Disease. In addition to this, Brazil’s economic dynamism has been inhibited by the pursuit of a growth with current account deficits (“foreign savings”) policy; an exchange rate anchor policy to control inflation; and a high level of interest rates. Collecti

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23

Curry, Nicola, and Raza Alikhan. Normal platelet function. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0281.

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The platelet is a small (2–4 µm in diameter), discoid, anucleate cell that circulates in the blood. In health, it plays a vital role in haemostasis, and in disease it contributes to disorders of bleeding and thrombosis. Platelets are produced from the surface of megakaryocytes in the bone marrow, under tight homeostatic control regulated by the cytokine thrombopoietin. Platelets have a lifespan of approximately 7–10 days, and usually circulate in the blood stream in a quiescent state. Intact, undamaged vessel walls help to maintain platelets in this inactive state by releasing nitric oxide, wh

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24

Reiter-Palmon, Roni, and Mackenzie Harms. Team Creativity and Innovation. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190222093.003.0001.

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For the past two decades, creativity and innovation have been viewed by researchers as critical to organizational success and survival. Understanding the factors that facilitate or inhibit creativity and innovation at the individual level has been the focus of much of the research in the area. In recent years, research in organizational psychology and management has focused on understanding creativity and innovation in teams. However, while earlier work on teams and creativity focused on the team as a context variable, and individual creativity as the outcome, more recent research emphasizes c

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25

Siebert, Stefan, Raj Sengupta, and Alexander Tsoukas, eds. Axial Spondyloarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198755296.001.0001.

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Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting mainly the sacroiliac joints and spine, resulting in pain, stiffness, and reduced movement. Over the past decade there have been major advances in many aspects of the disease, including a broadening of the disease description to axial spondyloarthritis (axSpA). While the many advances have transformed the lives of patients with axSpA, they have also increased complexity for non-specialists in this area. This handbook contains a timely update of the key developments and current state of play in axSpA. It is intended prima

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26

Alhazzani, Waleed, and Deborah J. Cook. Stress ulcer prophylaxis and treatment drugs in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0041.

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Many changes have occurred over the last three decades in the field of stress ulcer gastrointestinal bleeding and its prevention. The topic is controversial, fuelled by disparate data, studies at risk of bias, and the impression that the problem is not as serious as it once was. Indeed, compared with over four decades ago when mucosal ulceration of the stomach causing serious bleeding was first described, a relatively small proportion of critically-ill patients now develop clinically important bleeding. Acid suppression is commonly prescribed for stress ulcer prophylaxis (SUP), targeting subgr

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27

Figueiredo, Camille, and Georg Schett. Assessment of joint and bone structure in PsA patients: Using high-resolution computed tomography. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0019.

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Psoriatic arthritis (PsA) is associated with a distinct pattern of bone pathology, which influences the clinical picture of the disease. High-resolution computed tomography (CT) has contributed to understanding structural bone changes in PsA. Periarticular bone erosions in PsA are characterized by periosteal responses around the cortical break, distinguishing them from bone erosions in rheumatoid arthritis. Furthermore, a large number of enthesophytes can be found in CT studies of joints of PsA patients and in psoriasis patients without clinical arthritis. This latter observation supports the

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28

Purdon, Christine, and C. Psych. Pathological Responsibility, Thought-Action Fusion, and Thought Control in OCD. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0018.

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Leading models of obsessive-compulsive disorder (OCD) implicate overvalued beliefs about responsibility, beliefs about the relationship of thoughts to external events and morality (thought-action fusion), and thought control as key factors in the development and the persistence of the disorder. This chapter provides an overview of these three factors and presents case examples, empirical support, and clinical implications. Considerable empirical research indicates that people with OCD tend to endorse beliefs reflecting an overvalued responsibility and thought-action fusion (TAF). However, it i

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29

Furani, Khaled. Theology Revealing the Hājibs of Anthropology. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198797852.003.0005.

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This chapter proposes ways in which theology could promote a critique of idolatries in modern anthropology. It culls resources by scouring Nietzsche’s arguments against modernity. Nietzsche enables a vision of modern anthropology as symptomatic of God’s death in the West, thus inducing questions about the ways its adoration of idols may inhibit a truer inquiry. The chapter finds examples to this effect in anthropology’s engagement with the nation state, humanism, and the constitutive concept of culture. It then speculates as to how a theological repudiation of anthropology’s idols could suppor

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30

Hudson, Dale. “Making” Americans from Foreigners. Edinburgh University Press, 2018. http://dx.doi.org/10.3366/edinburgh/9781474423083.003.0003.

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Although conventional studies look to the earliest surviving vampire film, Prana-Films’ Nosferatu (1922) as source for visual codes and narrative conventions in Hollywood vampire media, this chapter locates them in segregation comedies, immigration romances, and miscegenation melodramas. These films establish conventions that facilitate or inhibit foreigners being americanized. Since citizenship for women was derivative from fathers or husbands, foreign women were considered less threatening. Consequently, male immigrants in Edison Company shorts (1895–1896), industrial and state recruitment f

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31

Henkel, Anna, Isolde Karle, Gesa Lindemann, and Micha Werner, eds. Sorget nicht - Kritik der Sorge. Nomos Verlagsgesellschaft mbH & Co. KG, 2019. http://dx.doi.org/10.5771/9783845289212.

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In the face of the overall state of affairs in society, which seems to be characterised by crises, (right-wing) populism, uncertainty and radicalisation, the concept of ‘concern’ appears to be a key idea in modern society. The underlying idea behind the discussion compiled in this book is to investigate concern from the perspective of a carefree attitude. Such an approach might provide us with a clearer understanding of the multifaceted and complex phenomenon of concern. Concern can be regarded as the manifestation of a longing for a carefree life without the burden of tedious tasks or demands

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Harrington, Brad, Beth Humberd, and Fred van Deusen. Work–Family Issues for Men. Edited by Tammy D. Allen and Lillian T. Eby. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199337538.013.33.

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Recent research shows that most fathers today seek roles that are much more integrated and engaged with the lives of their families than fathers in previous generations. However, society in general, and workplaces in particular, have been slow to adapt to these new fatherhood roles. This situation causes increased work–family conflict for fathers and leaves them in a situation in which their aspirations are often inconsistent with their realities. Although these changes are beginning to be noted, existing research in the work–family field has focused much more on the issues women face in integ

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33

Pollack, Detlef, and Gergely Rosta. Patterns and Determinants of Religious Change in the Modern Period. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198801665.003.0020.

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Chapter 14 does not design a general theory of religious change, but develops a multiple theoretical perspective including various theoretical elements, which are instrumental for explaining religious changes and which can be combined flexibly. In brief, they are: 1. Functional differentiation as a rule stands in a strained relationship to the integrational capacity of religious communities and churches. If, however, religious identities are linked with non-religious, for example, political, national, or economic interests, religion and church are strengthened. 2. Processes of individualizatio

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34

Foot, Rosemary. Restraints on Conflict in the China-US Relationship. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190675387.003.0005.

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Like the study of China itself, theorists of power transition have lately experienced a resurgence of interest in their arguments. As China has emerged as the world’s second-largest economy, with the second-largest military budget, and has become more assertive internationally under a seemingly more powerful president, the picture painted is one of growing morbidity: war between China, the putative rising dissatisfied power, and the United States, the declining hegemon, has allegedly become highly probable. This chapter critiques these arguments and highlights the restraints on conflict that g

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35

Maddux, Aline B., and Gordon R. Bernard. Immunomodulation strategies in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0312.

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Severe sepsis is a hyperimmune response to an infectious stimulus resulting in a surge of cytokines and mediators of inflammation. High circulating levels of pro-inflammatory cytokines lead to shock, multiple organ failure, and death in septic patients. It has been recognized that patients with sepsis progress into a state of immune paralysis characterized by immune cell apoptosis and high levels of anti-inflammatory cytokines… Anti-inflammatory cytokines suppress production of pro-inflammatory cytokines and inhibit monocytes from presenting antigens to other immune cells. Immune paralysis pro

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36

Waldek, Stephen. Fabry disease. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0338_update_001.

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Fabry disease is a rare X-linked lysosomal storage disorder in which deficiency of alpha-galactosidase A leads to accumulation of substrate, mostly globotriaosylceramide (Gb3), which causes a progressive, multiorgan disease affecting predominantly the kidneys, skin, heart, and nervous system. Painful peripheral (‘acral’) neuropathy is characteristic. Proteinuria and estimated glomerular filtration rate (eGFR) are strongly associated with risk of progression, but this may be reduced by treatment with angiotensin-converting enzyme inhibitors as well as by enzyme replacement therapy (ERT). ERT wa

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37

Swanepoel, R., and J. T. Paweska. Crimean-Congo haemorrhagic fever. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0033.

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Crimean-Congo haemorrhagic fever (CCHF) is an acute disease of humans, caused by a tick-borne virus which is widely distributed in eastern Europe, Asia and Africa. Cattle, sheep and small mammals such as hares undergo inapparent or mild infection with transient viraemia, and serve as hosts from which the tick vectors of the virus can acquire infection. Despite serological evidence that there is widespread infection of livestock in nature, infection of humans is relatively uncommon. Humans acquire infection from tick bite, or from contact with infected blood or other tissues of livestock or hum

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38

Ruxton, Graeme D., William L. Allen, Thomas N. Sherratt, and Michael P. Speed. Thanatosis. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199688678.003.0014.

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When physically restrained, many animals adopt a relatively immobile state that can last after the constraint has been released. The lack of movement is suggested to inhibit further attack by the predator and reduce the perceived need of the predator to continue to attack or constrain the prey. This phenomenon has been variously called death feigning, animal hypnosis, tonic immobility, and playing dead. However, we will use the term that the scientific literature seems to be coalescing around: thanatosis. Thanatosis is distinct from immobility used to reduce the risk of detection or tracking b

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39

O'Neill, Daniel C. Dividing ASEAN and Conquering the South China Sea. Hong Kong University Press, 2018. http://dx.doi.org/10.5790/hongkong/9789888455966.001.0001.

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The “ASEAN Way” is based on the principle of consensus; any individual member state effectively has a veto over any proposal it does not support. This book analyzes how China uses its financial power and influence to divide the member countries of ASEAN in order to prevent them from acting collectively to resolve their territorial disputes with China in the South China Sea. Comparative case studies of China’s relations with Cambodia, the Philippines, and Myanmar illustrate that the regime type in the country with which China is interacting plays an important role in enhancing or constraining C

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40

Avilez, GerShun. Black Queer Freedom. University of Illinois Press, 2020. http://dx.doi.org/10.5622/illinois/9780252043376.001.0001.

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In this book, GerShun Avilez argues that queerness, here meaning same-sex desire and gender nonconformity, introduces the threat of injury and that artists throughout the Black diaspora use queer desire to negotiate spaces of injury. The space of injury does not necessarily pertain to a particular architecture or location; it concerns the perception and engagement of a body. Black queer bodies are perceived as social threats, and this perception results in threats (physical, psychological, socioeconomic) against these bodies. The space of injury describes the potential threat to queer bodies t

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Whitworth, Caroline, and Stewart Fleming. Malignant hypertension. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0216.

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Malignant hypertension (MH) is recognized clinically by elevated blood pressure together with retinal haemorrhages or exudates with or without papilloedema (grades III or IV hypertensive retinopathy); and may constitute a hypertensive emergency or crisis when complicated by evidence of end-organ damage including microangiopathic haemolysis, encephalopathy, left ventricular failure, and renal failure. Though reversible, it remains a significant cause of end-stage renal failure, and of cardiovascular and cerebrovascular morbidity and mortality in developing countries.MH can complicate pre-existi

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