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Dissertations / Theses on the topic 'STAT. Inhibitor'

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Published: 4 June 2021

Last updated: 13 February 2022

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1

Younis, Usir, and Usir Younis. "Inhalational Delivery of a JAK3 Inhibitor for the Novel Treatment of Asthma and the Investigation of Pharmaceutical Salts in HFA Propellant Systems." Diss., The University of Arizona, 2018. http://hdl.handle.net/10150/626756.

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Asthma is a significant lung disease involving chronic inflammation and remodeling of the airways, resulting in reduced quality of life for those who suffer from the condition. Current therapeutic guidelines suggest the use of inhaled corticosteroids for long-term anti-inflammatory relief to manage moderate to severe chronic asthma; however, inhaled corticosteroids fail to provide prophylactic or reversal treatment of damaged airways incurred by chronic asthma as well as exhibiting adverse side effects (skeletal complications, diabetes, and weight gain).Therefore, there is a need for a new typ

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2

Torikoshi, Kazuo. "Protein inhibitor of activated STAT, PIASy regulates α-smooth muscle actin expression by interacting with E12 in mesangial cells". Kyoto University, 2013. http://hdl.handle.net/2433/174820.

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3

Martin, Nadine. "Rôle de la SUMO E3 ligase PIASy dans les mécanismes de contrôle de la prolifération cellulaire et de réponse aux dommages." Paris 6, 2007. http://www.theses.fr/2007PA066243.

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La modification des protéines par SUMO joue un rôle important dans de nombreuses fonctions cellulaires. Le travail présenté dans cette thèse vise à analyser l'action des protéines PIAS, régulateurs transcriptionnels et SUMO E3 ligases, et en particulier de PIASy dans le contexte de l'oncogenèse. Nous avons montré que PIASy induit la sénescence des fibroblastes primaires, en activant les voies Rb et p53, ou l'apoptose si la voie Rb est déficiente. Nous avons parallèlement identifié de nouveaux partenaires protéiques de PIASy. PIASy induit l'accumulation de FIP200 dans le noyau, ce qui inhibe l'

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4

Aubert-Jürgens, Ana. "STAT3 inhibitors for cancer treatment." [S.l.] : [s.n.], 2005. http://elib.tu-darmstadt.de/diss/000563.

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5

Ricard, Laure. "Les lymphocytes T folliculaires auxiliaires dans la sclérodermie systémique." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS340.

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La sclérodermie systémique (SSc) est une maladie auto-immune, caractérisée par une atteinte microvasculaire oblitérante, de la fibrose et des anomalies de l'immunité humorale. Les lymphocytes T folliculaires auxiliaires (Tfh) CD4+CXCR5+PD1+ coopèrent avec les lymphocytes B pour induire leur différenciation en plasmocytes sécréteurs d’immunoglobulines (Ig). Les Tfh circulants (cTfh) sont augmentés dans plusieurs maladies auto-immunes et les Tfh infiltrent la peau des patients SSc. Nous avons observé que les cTfh des patients SSc étaient augmentés en comparaison avec les témoins et notamment dan

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6

Ball, Sarah Lynnette. "Small molecule inhibitors, LLL12 and celecoxib, effectively inhibit STAT3 phosphorylation, decrease cellular viability and induce apoptosis in medulloblastoma and glioblastoma cell lines." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1298906960.

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7

Hill, Jacqueline M. "Transition state analogues as inhibitors of metallo-proteases." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260112.

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8

Fisher, Michael I. "Transition state analogue inhibitors of the aspartyl proteases." Thesis, University of Huddersfield, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363233.

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9

Ekegren, Jenny. "Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6737.

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10

Ghafoory, Shima. "Development of a screening assay for inhibitors of inflammation useful against pancreatic cancer." Thesis, Mälardalen University, Mälardalen University, School of Sustainable Development of Society and Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-7797.

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<p>Pancreatic cancer is the fourth most lethal cancer and ranks as the eighth most commonly diagnosed cancer worldwide. This is due to its rapid proliferation, strong metastatic potential and its delayed detection. One major risk factor for developing pancreatic cancer is the aggressive inflammatory disease chronic pancreatitis. Chronic inflammation frequently precedes the development of certain pancreatic cancers.</p><p>Inflammation is a protective and necessary process by which the body can alert the immune system of the existence of a wound or infection and mount an immune response to remov

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11

Bhasin, Deepak. "Small Molecule Inhibitors asAnticancer Agents." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1305826098.

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12

Gonzalez, Palmén Lorena. "Homotrimeric dUTPases : Principles of Catalysis and Inhibitor Design." Doctoral thesis, Högskolan i Kalmar, Naturvetenskapliga institutionen, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-6119.

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The ubiquitous enzyme dUTPase hydrolyzes dUTP into dUMP and pyrophosphate, preventing DNA fragmentation and cell death due to accumulation of dUTP. Inhibitors of dUTPase could serve as drugs in the treatment of cancers and infectious diseases. This thesis presents five studies. A mutational study on the Escherichia coli dUTPase (S72A) provides new insights about the catalytic principles of the homotrimeric dUTPases. A model is presented in which transition state formation is associated with a rotation of the conserved Ser72 side chain. The model can explain the strict order of deamination and

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13

Haque, Mohammad Rashedul. "Novel STAT3 small-molecule inhibitors as potential anticancer agents." Thesis, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535504.

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14

Mautsa, Nicodemus. "Structural and functional characterisation of the protein inhibitor of activated STAT3 (PIAS3)." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1004050.

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The signal transducer and activator of transcription (STAT) and protein inhibitor of STAT(PIAS) system represent an elegant regulatory mechanism of transcriptional control IN mammalian cytokine signalling. Abnormal activation of the system is associated with immune disorders and a large group of diverse tumours. PIAS3 is a multiple domain protein with distinct functions involved in regulation of cytokine-mediated gene activation pathways.Its over-expression significantly inhibits cell growth and renders cancer cells more sensitive to drugs. The objective of this study was to structurally and b

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15

Singh, Danny Ravinder. "Phosphorus containing transition state analogue inhibitors of the aspartyl proteases." Thesis, University of Huddersfield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368303.

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16

Chamberlain, Christopher Daniel. "Development and validation of assays used to evaluate STAT3 inhibitors." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/development-and-validation-of-assays-used-to-evaluate-stat3-inhibitors(007f8426-c173-4802-955e-181bf9aec424).html.

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Transcription factors are important control proteins in cells that bind to their cognate DNA sequences in the promoter regions of genes, either up-regulating or down-regulating protein expression. In many cancer types, transcription factors are up-regulated and promote the expression of genes important in survival and metastasis. For this reason, transcription factors are good targets for novel anticancer agents. The STAT family of transcription factors (seven are now acknowledged) recognize and bind to a ~10 base pair sequence of DNA in the promoter region of a number of genes, enhancing the

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17

Etter, Jonathan Parker. "Development of Inhibitors in the IL-6/GP130/JAK/STAT Pathway as Therapeutic Agents." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1376525461.

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18

Zhang, Yixi. "Targeting STAT3 in Ovarian Cancers: Reciprocal Activation of NF-kB by STAT3 Inhibition." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:27007758.

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The transcription factor STAT3 normally modulates cell proliferation with a rapid and transient downstream effect. However, in tumor cells, inappropriately activated STAT3 alters the gene expression profile and renders tumor cells unresponsive to cell death signals. In this study, we examine the biological and biochemical effects of some STAT3 inhibitors on ovarian and cervical cancer cells. Furthermore, we study the reciprocal relationship between STAT3 and NF-kB—another prosurvival transcription factor—in ovarian cancer cells. Inappropriate activation of STAT3 occurs in many cancers and

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19

Smith, Cressida Sally. "Design and synthesis of novel transition state isostere inhibitors of MurD." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418195.

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20

Wang, Xiaodong. "Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/26625.

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Pin1 (protein interacting with NIMA 1) is a peptidyl-prolyl isomerase involved in mitosis. As a potential anti-cancer drug target, Pin1 interacts and regulates the activity of an increasing number of cell cycle enzymes by an unknown mechanism. These cell cycle enzymes include Cdc25, Cdc27, Cyclin D1, Myt1, Wee1, NIMA, Cdc2, Plk1 and c-Myc. Recent research has revealed that Pin1 is overexpressed in a variety of cancer cell lines and Pin1 inhibitors inhibit proliferation activity of several cancer cells overexpressing Pin1. The most potent Pin1 inhibitors identified so far are in the micromolar

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21

Couto, Jason. "Biologic Activity of the Novel Small Molecule STAT3 Inhibitor Against Canine Osteosarcoma Cell Lines." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1373986927.

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22

Ziegler, Inna. "Posttranslationale Modifikationen der IL-6-Typ-Zytokin-Rezeptoren gp130 und LIFR und ihr Einfluss auf die Assoziation mit Detergenz-resistenten Membranmikrodomänen (DRM)." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:100-opus-3124.

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23

Misale, Antonio. "Synthesis of angucycline-based small molecules as potential STAT3 : STAT3 protein-protein interaction inhibitors for cancer therapy." Thesis, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555844.

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Inhibition of the ST AT3: ST AT3 protein-protein interaction is an attractive approach for cancer therapy as it can lead to suppression of tumour cell growth and induce apoptosis. The racemic ochromycinone (STA21) is one of the few known small-molecule STAT3:STAT3 inhibitors. Our synthetic efforts focused on synthesis of the natural product YM-181741, which possesses at least three points for chemical variation to prepare compound libraries as potential STAT3:STAT3 inhibitors. Synthesis of the angucycline molecule was achieved employing an approach based on a Gold (lII)-catalysed intramolecula

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24

Wang, Xinning [Verfasser]. "Tetrazole-containing STAT5 Inhibitors Derived from Furazan-based Phosphate Mimetics / Xinning Wang." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/121464130X/34.

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25

Laver, Travis. "Mechanism of inteferon-beta-mediated inhibition of IL-8 gene expression." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/laver.pdf.

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26

Miller, David James. "Phosphinic acids as inhibitors of D-Ala-D-Ala adding enzyme." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242865.

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27

Xu, Guoyan. "Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/37823.

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An important role of Pin1 is to catalyze the cis-trans isomerization of pSer/Thr-Pro bonds; as such, it plays an important role in many cellular events through the effects of conformational change on the function of its biological substrates, including Cdc25, c-Jun, and p53. The expression of Pin1 correlates with cyclin D1 levels, which contributes to cancer cell transformation. Overexpression of Pin1 promotes tumor growth, while its inhibition causes tumor cell apoptosis. Because Pin1 is overexpressed in many human cancer tissues, including breast, prostate, and lung cancer tissues, it plays

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28

Schust, Jochen. "Neue Ansätze zur Identifizierung niedermolekularer Inhibitoren der STAT3-Aktivierung und -Homodimerisierung." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982197438.

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29

Al-Lami, Naeemah. "Synthesis of nitrogen-containing bicyclic sesquiterpenes as potential transition state inhibitors of aristolochene synthase." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/53674/.

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Aristolochene synthase from Penicillium roqueforti(PR-AS) is sesquiterpene synthase that catalyses the Mg2+-dependent conversion of farnesyl diphosphate FDP to (+)-aristolochene. Through the use of site directed mutagenesis, fluorinated FDPs and an aza-analogue of the eudesmane cation, the reaction was previously shown to involve germacrene A and eudesmane cation as intermediates. The subsequent series of rearrangements that transform the eudesmane cation to (+)-aristolochene have not been investigated previously. To probe the carbocationic nature of these 1,2-hydride and methyl shifts, new az

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30

Maughan, Michael A. T. "Cyclic imine sugars : towards the synthesis of transition-state mimics as potential glycosyltransferase inhibitors." Thesis, Durham University, 2003. http://etheses.dur.ac.uk/3694/.

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This thesis describes the development of methodology for the synthesis of cyclic imine-sugars, and their use in the synthesis of aza-sugars as potential sugar-processing enzyme inhibitors. Our goals include the synthesis of cyclic imines of L-rhamnose, D-glucose, and L-idose stereochemistry, and the introduction of functionality via nucleophilic addition reactions. Work on the synthesis of cyclic imines commenced with the use of the simple model systems piperidme and 2-methylpiperidine. N-Chlorination of these systems was performed and the products converted into their cyclic imine derivatives

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31

Feng, You. "Kinetic Mechanism and Inhibitory Study of Protein Arginine Methyltransferase 1." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/chemistry_diss/68.

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Protein arginine methyltransferase 1 (PRMT1) is a key posttranslational modification enzyme that catalyzes the methylation of specific arginine residues in histone and nonhistone protein substrates, regulating diverse cellular processes such as transcriptional initiation, RNA splicing, DNA repair, and signal transduction. Recently the essential roles of PRMT1 in cancer and cardiovascular complications have intrigued much attention. Developing effective PRMT inhibitors therefore is of significant therapeutic value. The research on PRMT inhibitor development however is greatly hindered by poor u

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32

Csatary, Erika Elizabeth. "Asymmetric Multicomponent Aza-Diels-Alder Reaction for Construction of Multicyclic Heterocycles and Development of XZH-5 Derivatives as Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3)." Miami University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1435110305.

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33

Altundas, Abdullah Bilal. "Synthesis of XZH-5 Derivatives as Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) and Synthesis of π-Extended Tetraphenylporphyrins". Miami University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=miami1473201129.

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34

Yu, Wenying. "Computational, Synthetic, Biochemical and Biological Studies and Characterization on STAT3 Inhibitors for Potential Anticancer Therapy." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1373328058.

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35

Turner, Kimberly Ann. "Deliberate Memory in Three-Year-Old Children: Interrelations among Task Approaches, Working Memory, and Inhibitory Control." NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-03242008-181800/.

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Preschool children are capable of displaying strategies in memory tasks and demonstrating an early understanding of memorization (e. g., Wellman, 1988; Baker-Ward, Ornstein, & Holden, 1984). Questions remain, however, about the origins of strategic behavior in early childhood. A great deal of recent attention has been devoted to the interrelations among working memory and measures of executive functioning/inhibitory control in elementary-school children (e.g., Schneider, Schumann-Hengsteler, & Sodian, 2005). The goal of this investigation was to extend this work to preschool children in order

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36

Shumate, Howard W. "Repeated Alcohol Use and Sober-State Reactive Aggression: The Mediating and Moderating Role of Sober-State Executive Cognitive Functioning." Thesis, Virginia Tech, 2005. http://hdl.handle.net/10919/33397.

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This study examined the cumulative, more insidious, impact of repeated drinking on sober-state aggression based on research that has pointed to the negative neural effects of chronic alcohol consumption, especially on frontal lobe functioning. In particular, it examined the relationship between repeated alcohol use and sober-state reactive aggression as it is mediated or moderated by sober-state executive cognitive functioning (ECF), thus expanding upon research that has examined the relationship between acute alcohol intoxication and consequent aggression while under the influence (Giancola,

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37

Dimberg, Lina. "Apoptosis Regulation in Multiple Myeloma." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7099.

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38

Frase, Hilary. "TOWARDS DEVELOPING SPECIFIC INHIBITORS OF THE ATP-DEPENDENT LON PROTEASE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1175637588.

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39

Khatchaturyan, Levon [Verfasser], Udo [Akademischer Betreuer] Markert, Uta-Christina [Akademischer Betreuer] Hipler, and Ulrike [Akademischer Betreuer] Kämmerer. "Die Rolle von PIAS (Protein Inhibitors of Activated STATs) in der Regulation von STAT (Signal Transducer and Activator of Transcription) : vermittelten Funktionen trophoblastärer Zellen / Levon Khachaturyan. Gutachter: Udo Markert ; Uta-Christina Hipler ; Ulrike Kämmerer." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2012. http://d-nb.info/1020402113/34.

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40

DAKA, PHILIAS. "ENAMINE-METAL LEWIS ACID BIFUNCTIONAL CATALYSTS FOR ASYMMETRIC ALDOL REACTIONS. DESIGN AND SYNTHESIS OF STAT3 INHIBITORS." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1374852476.

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41

Tse, Joyce. "Inhibition of STAT3 decreases OSM induced EDA-FN expression in human lung fibroblasts." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/33839.

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Fibrosis is excessive deposition of connective tissue components that results in the destruction of normal tissue architecture and compromises organ function. When fibrosis occurs in the major organs such as the lung, for example in idiopathic pulmonary fibrosis (IPF), it inevitably leads to organ failure and premature death of the afflicted individual. The development of fibrosis follows a similar pathway to normal wound healing, although there is chronic progression of the disease without resolution, suggesting the fine control of cellular functions that occur during wound healing is disturb

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42

Moreno, Fortuño David. "Prions i Agregons com a Inhibidors de Start: una Via a l’Envelliment Cel·lular." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/404674.

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Saccharomyces cerevisiae és un model escaient per estudiar el procés d’envelliment a nivell cel.lular gràcies al seu mecanisme de divisió asimètrica. Fent una analogia amb l’envelliment en organismes superiors, on les cèl.lules somàtiques són pròpies de l’individu i envelleixen amb ell, mentre que les cèl.lules de la línia germinal són capaces de formar un nou individu i són virtualment immortals en la població, en S. cerevisiae podem diferenciar dos tipus de cèl.lules: les cèl.lules mare, que envelleixen i poden produir unes 20-30 cèl.lules filles, i les cèl.lules filles, que són capaces d’es

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43

Brown, Megan. "Characterization of STAT3 Expression, Signaling and Inhibition in Feline Oral Squamous Cell Carcinoma." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429621442.

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44

Goodall, Scott. "Probing the structure of acetylcholinesterase inhibitors in their binding site using solid state nuclear magnetic resonance." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270619.

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45

Hernández, Ribes Gracia. "ESTUDIO DE LA RUTA CELULAR JAK2/STAT3 COMO POTENCIAL INHIBIDOR EN EL MODELO DE FIBROSIS PULMONAR." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/64087.

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[EN] Idiopathic pulmonary fibrosis (IPF) is the pulmonary disease with higher incidence and worse prognosis. Recent evidence suggests that cucurbitaceae, selective inhibitors of the JAK2/STAT3 pathway, may improve the pathogenesis of IPF, as anti-inflammatory and antioxidative properties have been confirmed in other diseases. However the role in IPF is unknown. Two pharmacological models were investigated in the present study. In the preventive model, Wistar rats were instilled intratracheally with a single dose of bleomycin (BLM)(3.75 U/kg; n=12) to induce lung injury. CuI (20mg/kg/day; n=6)

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46

Ah, Koon Laurent. "Etude du rôle modulateur de STAT1 sur les réponses cellulaires induites par deux stratégies anticancéreuses : -Chimiothérapie par les agents alkylants : -Biothérapies utilisant un oligonucléotide leurre inhibiteur de STAT3." Paris 13, 2012. http://scbd-sto.univ-paris13.fr/secure/edgalilee_th_2012_ah_koon.pdf.

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Les membres de la famille des facteurs STAT ont des rôles modulateurs très différents. Dans cette famille, STAT1 et STAT3 sont très similaires, peuvent réguler les mêmes gènes cibles mais sont caractérisés par des rôles opposés. STAT1 est considéré comme un anti-oncogène tandis que STAT3 serait plutôt un oncogène. Le facteur de transcription STAT1 est impliqué dans plusieurs voies de signalisations visant à protéger la cellule. STAT1 est un facteur antiprolifératif et proapoptotique. Le rôle modulateur de STAT1 de l’action de certains agents génotoxiques a été démontré et semble dépendre à la

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47

Startzman, Ashley N. "Inhibition of stat3 protein as an approach to sensitizing ovarian cancer cells to cisplatin." Honors in the Major Thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1143.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Medicine<br>Molecular Biology and Microbiology

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48

Wong, Ee Lin [Verfasser]. "The transcription factor STAT5 catalyzes Mannich ligation reactions yielding inhibitors of leukemic cell proliferation / Ee Lin Wong." Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1201346711/34.

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49

Camerino, Eugene. "Trifluoromethyl ketones: Potential insecticides towards Anopheles gambiae." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/54015.

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Malaria continues to cause significant mortality in sub-Saharan Africa and elsewhere, and existing vector control measures are being threatened by growing resistance to pyrethroid insecticides. With the goal of developing new human-safe, resistance-breaking insecticides we have explored several classes of acetylcholinesterase inhibitors. In vitro assay studies have shown that trifluoromethyl ketones (TFK\'s) are potent inhibitors of An. gambiae AChE (AgAChE), that inhibit the enzyme by making a covalent adduct with the catalytic serine of the enzyme. However research in the Carlier group ha

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50

Wooldridge, Lydia Katherine. "Supplementing Bovine Embryo Culture Media to Improve the Production and Quality of In Vitro Produced Bovine Embryos." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/105143.

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Initial studies in this work explored the role of interleukin-6 (IL6) and leukemia inhibitory factor (LIF) in preimplantation bovine embryos. Neither cytokine affected the total percentage of embryos which developed to the blastocyst stage in vitro. However, supplementation of IL6 increased blastocyst inner cell mass (ICM) cell number without affecting trophectoderm (TE) cell number. Additionally, we found that IL6 activated signal transducer and activator of transcription 3 (STAT3) specifically within ICM cells. LIF, however, did not affect ICM cell number or activate STAT3 in ICM cells, and

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