Academic literature on the topic 'STAT'

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Journal articles on the topic "STAT"

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Ebersbach, Celina, Alicia-Marie K. Beier, Christian Thomas, and Holger H. H. Erb. "Impact of STAT Proteins in Tumor Progress and Therapy Resistance in Advanced and Metastasized Prostate Cancer." Cancers 13, no. 19 (2021): 4854. http://dx.doi.org/10.3390/cancers13194854.

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Signal transducers and activators of transcription (STATs) are a family of transcription factors involved in several biological processes such as immune response, cell survival, and cell growth. However, they have also been implicated in the development and progression of several cancers, including prostate cancer (PCa). Although the members of the STAT protein family are structurally similar, they convey different functions in PCa. STAT1, STAT3, and STAT5 are associated with therapy resistance. STAT1 and STAT3 are involved in docetaxel resistance, while STAT3 and STAT5 are involved in antiand
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Konjevic, Gordana. "STAT proteins in cancerogenesis and therapy of malignancies." Srpski arhiv za celokupno lekarstvo 137, no. 1-2 (2009): 98–105. http://dx.doi.org/10.2298/sarh0902098k.

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Signal transducers and activators of transcription (STAT) proteins are a 7-member family of cytoplasmic transcription fators that participate in signal transduction by cytokines, hormones, and growth factors. STAT proteins control the most important cellular processes, including survival, proliferation and differentiation. A great number of cytokines and other factors in different cell types activate STAT1, STAT3 and STAT5 and in this manner regulate processes such as cellular proliferation, differentiation and survival. STATs such as STAT4 and STAT6 have a more specific effect and are engaged
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de Haas, Nienke, Coco de Koning, Stefania di Blasio, Georgina Flórez-Grau, I. Jolanda M. de Vries, and Stanleyson V. Hato. "STAT Family Protein Expression and Phosphorylation State during moDC Development Is Altered by Platinum-Based Chemotherapeutics." Journal of Immunology Research 2019 (June 11, 2019): 1–12. http://dx.doi.org/10.1155/2019/7458238.

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The STAT signaling pathway is important in dendritic cell (DC) development and function. Tumor cells can induce STAT signaling, thereby inhibiting DC maturation and immunostimulatory functions, leading to hampered efficacy of DC-based immunotherapies. Platinum-based chemotherapeutics can inhibit STAT signaling, thereby making them an interesting tool to improve DC development and function. In this study, we provide a comprehensive overview of STAT expression and phosphorylation during DC differentiation and maturation and investigate the effects of platinum drugs on STAT signaling during these
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Lee, Hyun-Ku, Gita Singh, and Sujay Singh. "STAT reporter cell line systems as a tool for cancer therapeutic target screening." Journal of Immunology 200, no. 1_Supplement (2018): 169.8. http://dx.doi.org/10.4049/jimmunol.200.supp.169.8.

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Abstract Signal transducer and activator of transcription (STAT) proteins as cytoplasmic transcription factors respond to cytokines and growth factors that mediate downstream signaling. STATs are closely related with cancers as they are frequently found to be dysregulated in primary tumors, leading to enhanced survival of tumors and increased angiogenesis. Among seven STAT family members, STAT3, STAT4 and STAT5 are considered to primarily promote cancer development and progression, while STAT1 may function either as a tumor suppressor or tumor promoter. STAT3, 4 and 5 are persistently activate
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Gorissen, Marnix, Erik de Vrieze, Gert Flik, and Mark O. Huising. "STAT genes display differential evolutionary rates that correlate with their roles in the endocrine and immune system." Journal of Endocrinology 209, no. 2 (2011): 175–84. http://dx.doi.org/10.1530/joe-11-0033.

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We identified orthologues of all mammalian Janus kinase (JAK) and signal transducer and activator of transcription (STAT) genes in teleostean fishes, indicating that these protein families were already largely complete before the teleost tetrapod split, 450 million years ago. In mammals, the STAT repertoire consists of seven genes (STAT1, -2, -3, -4, -5a, -5b, and -6). Our phylogenetic analyses show that STAT proteins that are recruited downstream of endocrine hormones (STAT3 and STAT5a and -5b) show a markedly higher primary sequence conservation compared with STATs that convey immune signals
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Tian, SS, P. Tapley, C. Sincich, RB Stein, J. Rosen, and P. Lamb. "Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes." Blood 88, no. 12 (1996): 4435–44. http://dx.doi.org/10.1182/blood.v88.12.4435.bloodjournal88124435.

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Granulocyte colony-stimulating factor (G-CSF) is the major regulator of proliferation and differentiation of neutrophilic granulocyte precursor cells. G-CSF activates multiple signaling molecules, including the JAK1 and JAK2 kinases and the STAT transcription factors. To investigate G-CSF signaling events regulated by the JAK-STAT pathway, we have generated UT7-epo cells stably expressing either wild-type (wt) G-CSF receptor or a series of C-terminal deletion mutants. Gel mobility shift and immunoprecipitation/Western analysis showed that STAT5 is rapidly activated by G-CSF in cells expressing
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Chen, Honglin, Lindsey Hutt-Fletcher, Liang Cao, and S. Diane Hayward. "A Positive Autoregulatory Loop of LMP1 Expression and STAT Activation in Epithelial Cells Latently Infected with Epstein-Barr Virus." Journal of Virology 77, no. 7 (2003): 4139–48. http://dx.doi.org/10.1128/jvi.77.7.4139-4148.2003.

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ABSTRACT STAT3 and STAT5 are constitutively activated and nuclear in nasopharyngeal carcinoma (NPC) cells. In normal signaling, STATs are only transiently activated. To investigate whether Epstein-Barr virus (EBV), and in particular the protein LMP1, contributes to sustained STAT phosphorylation and activation in epithelial cells, we examined STAT activity in two sets of paired cell lines, HeLa, an EBV-converted HeLa cell line, HeLa-Bx1, the NPC-derived cell line CNE2-LNSX, and an LMP1-expressing derivative, CNE2-LMP1. EBV infection was associated with a significant increase in the tyrosine-ph
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Murphy, Theresa L., Erik D. Geissal, J. David Farrar, and Kenneth M. Murphy. "Role of the Stat4 N Domain in Receptor Proximal Tyrosine Phosphorylation." Molecular and Cellular Biology 20, no. 19 (2000): 7121–31. http://dx.doi.org/10.1128/mcb.20.19.7121-7131.2000.

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ABSTRACT Stat4 is activated by the cytokines interleukin 12 and alpha interferon (IFN-α) and plays a significant role in directing development of naı̈ve CD4+ T cells to the Th1 phenotype. Signal transducers and activators of transcription (STAT) proteins undergo phosphorylation on a conserved tyrosine residue, resulting in homo- and heterodimerization, nuclear translocation, and DNA binding. Stat4 can bind to single IFN-γ-activated sites (GASs) as a dimer or bind two tandem GASs as a pair of STAT dimers, or tetramer, stabilized through N-terminal domain (N domain) interactions between dimers.
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Guo, DanQun, James D. Dunbar, Chuan He Yang, Lawrence M. Pfeffer, and David B. Donner. "Induction of Jak/STAT Signaling by Activation of the Type 1 TNF Receptor." Journal of Immunology 160, no. 6 (1998): 2742–50. http://dx.doi.org/10.4049/jimmunol.160.6.2742.

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Abstract Cellular responses to TNF are initiated by either of two cell surface receptors, the type 1 TNF receptor (TNFR1) and the type 2 TNF receptor (TNFR2). Although neither receptor contains an intrinsic protein tyrosine kinase, such activity has been implicated in TNF action. In this study, we show that murine TNF induces the tyrosine phosphorylation and activation of the intracellular Janus tyrosine kinases Jak1, Jak2, and Tyk2 in murine 3T3-L1 adipocytes. Activation of Jak kinases by TNF was associated with tyrosine phosphorylation of STAT1, STAT3, STAT5, and STAT6, but not STAT2 or STAT
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Morgan, Ethan L., and Andrew Macdonald. "Manipulation of JAK/STAT Signalling by High-Risk HPVs: Potential Therapeutic Targets for HPV-Associated Malignancies." Viruses 12, no. 9 (2020): 977. http://dx.doi.org/10.3390/v12090977.

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Human papillomaviruses (HPVs) are small, DNA viruses that cause around 5% of all cancers in humans, including almost all cervical cancer cases and a significant proportion of anogenital and oral cancers. The HPV oncoproteins E5, E6 and E7 manipulate cellular signalling pathways to evade the immune response and promote virus persistence. The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway has emerged as a key mediator in a wide range of important biological signalling pathways, including cell proliferation, cell survival and the immune response. While STAT1 and
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Dissertations / Theses on the topic "STAT"

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Is'Harc, Hayaatun. "JAK/STAT signalling." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272414.

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Strickland, Janae. "The Role of STAT and the Jak/STAT Pathway In Mediating the Effects of Interleukin-6 on StAR Expression." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1781.pdf.

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Une-Larsson, Martin. "Verkställighet mot främmande stat." Thesis, Stockholms universitet, Juridiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-129856.

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Lif, Zophie. "Stat i världen : En studie av Islamiska staten i förhållande till begreppet stat." Thesis, Mittuniversitetet, Avdelningen för samhällsvetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-26888.

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Titel: Stat i världen – En studie av Islamiska staten i förhållande till begreppet stat  Kurs: Statsvetenskap C, Mittuniversitetet, vårterminen 2015 Författare: Zophie Lif Nyckelord: Statsvetenskap, Islamiska staten, stat, begreppsdefinition, kvalitativ metod Bakgrund Islamiska staten är en av flera islamistiska rörelser som på senare tid vunnit stora politiska och territoriella framgångar. Organisationen utmärker sig genom att göra anspråk på ett världsomspännande kalifat som ska omfatta hela världens muslimska befolkning.I västvärlden har Islamiska staten främst uppmärksammat för sitt extrem
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Lindström, Dag. "Skrå, stad och stat : Stockholm, Malmö och Bergen ca. 1350-1622 /." Stockholm : Almqvist och Wiksell, 1991. http://catalogue.bnf.fr/ark:/12148/cb35512925f.

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Laurén, Pär. "Sekt, stat och apokalyptiskt våld." Thesis, University of Gävle, Ämnesavdelningen för religionsvetenskap, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-3776.

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<p>Denna uppsats behandlar det fenomen som uppstår när en, mer eller mindre isolerad, grupp religiöst hängivna människor, hamnar i en så pass allvarlig konflikt med staten och dess instutitioner att våldsamheter uppstår. Fenomenet brukar gå under beteckningen fanatiskt religiöst våld, och är i dess västerländska tappning mer eller mindre synonymt med sekter och sekterism.</p><p>P.g.a. ämnets digra karaktär är en kraftig begränsning nödvändig för att kunna behandla ämnet i en C-uppsats. Jag har därför gjort valet att koncentrera mig på de två mest extrema och medialt uppmärksammade fallen av re
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Hagberg, Axel. "Bankkrishantering : aktörer, marknad och stat." Doctoral thesis, Handelshögskolan i Stockholm, EHFF - Stiftelsen för Ekonomisk-historisk och Företagshistorisk Forskning, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hhs:diva-1264.

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I likhet med i andra länder har det i Sverige under vissa högkonjunkturer uppstått ett så betydande kapitalöverskott, att den finansiella marknaden fått problem att bemästra flödena. Konsekvensen har blivit att den aggregerade risknivån ökat i takt med stigande tillgångspriser. När väl en kontraktion uppstått, har det saknats kapital för att i ordnade former bemästra de nya ekonomiska förutsättningarna. Det är den utvecklingen som föregått kriserna 1878/79, 1921/22 och 1991/92. Temporära insatser har då måst ske vid sidan av det befintliga institutionella systemet. Forskningen ger för Sveriges
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Hagberg, Axel. "Bankkrishantering : aktörer, marknad och stat /." Stockholm : Handelshögskolan i Stockholm : Ekonomiska forskningsinstitutet vid Handelshögskolan i Stockholm (EFI) [distributör], 2007. http://www2.hhs.se/EFI/summary/725.htm.

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Dawson, M. A. F. "JAK-STAT signalling at chromatin." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598423.

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The aim of my work was to explore the possibility that the mammalian JAK2 signalling pathway influences the structure and function of chromatin. I have demonstrated that JAK2 is present in the nucleus of both human haematopoietic cell lines and primary cells. My results suggest that JAK2 functions as a histone tyrosine kinase and phosphorylates histone H3 at tyrosine-41 (H3Y41). This novel histone modification, the first described tyrosine phosphorylation on any of the non-variant histones, regulates the binding of heterochromatin protein 1-alpha (HP1α) at a new binding site on chromatin. HP1α
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Hjelmqvist, Ingvar. "Relationer mellan stat och kommun." [Stockholm] : Stockholms universitet, Statsvetenskapliga institutionen, 1994. http://books.google.com/books?id=yi0FAQAAIAAJ.

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Books on the topic "STAT"

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Johnson, Robert Russell. Stat. 2nd ed. Brooks/Cole Cengage Learning, 2010.

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Messmer, Craig M. Stat One. McGraw-Hill, 2008.

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Brett, Hudson, ed. Stat man. Barrington Stoke, 2007.

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SAS Institute. SAS Stat Studio 3.1 for SAS/STAT users. SAS Institute, 2008.

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SAS Institute. SAS Stat Studio 3.11 for SAS/STAT Users. SAS, 2009.

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SAS Institute. SAS Stat Studio 3.1 for SAS/STAT users. SAS Institute, 2008.

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Christensen, Jørgen Grønnegård. Den usynlige stat. Gyldendal, 1991.

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Nicholson, Sandra E., and Nicos A. Nicola, eds. JAK-STAT Signalling. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-242-1.

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Kotov, A. Kak stat' grossmeĭsterom. Russian Chess House, 2007.

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Min'jar-Belorucev, R. K. Kak stat' perevodcikom? Gotica, 1999.

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Book chapters on the topic "STAT"

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Lim, Su Jun, and Willis X. Li. "STAT." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_636.

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Vidal, C., and W. R. Külpmann. "STAT." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_2896-1.

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Vidal, C., and W. R. Külpmann. "STAT." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_2896.

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Lim, Su Jun, and Willis X. Li. "STAT." In Encyclopedia of Signaling Molecules. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_636-1.

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Lynch, Gordon S., David G. Harrison, Hanjoong Jo, et al. "STAT." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_3071.

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Dempsey, Brian R., Anne C. Rintala-Dempsey, Gary S. Shaw, et al. "SSI (STAT-Induced STAT Inhibitor)." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101283.

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Gressner, A. M., and O. A. Gressner. "STAT-Labor." In Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_2903-1.

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Gressner, A. M., and O. A. Gressner. "STAT-Labor." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_2903.

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Gooch, Jan W. "Anti-Stat." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_725.

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Johannessen, Janne Bondi, Kristin Hagen, André Lynum, and Anders Nøklestad. "OBT+stat." In Exploring Newspaper Language. John Benjamins Publishing Company, 2012. http://dx.doi.org/10.1075/scl.49.03joh.

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Conference papers on the topic "STAT"

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dazhi, ren, lv shengli, li jinlin, li naining, and dang lin. "STAT-Net: spatiotemporal aggregation transformer network for skeleton-based few-shot action recognition." In Third International Conference on Communications, Information System and Data Science 2024, edited by Daniele Giusto, Cheng Siong Chin, Yonghui Li, and Shensheng Tang. SPIE, 2025. https://doi.org/10.1117/12.3058329.

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Barnett, Mike, Badrish Chandramouli, Robert DeLine, et al. "Stat!" In the 2013 international conference. ACM Press, 2013. http://dx.doi.org/10.1145/2463676.2463683.

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Zhang, Baogang, Necati Uysal, and Rickard Ewetz. "STAT." In GLSVLSI '19: Great Lakes Symposium on VLSI 2019. ACM, 2019. http://dx.doi.org/10.1145/3299874.3318032.

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Kunath, Stephen A., and Steven H. Weinberger. "STAT." In Human Language Technologies: The 2009 Annual Conference of the North American Chapter of the Association for Computational Linguistics, Companion Volume: Demonstration Session. Association for Computational Linguistics, 2009. http://dx.doi.org/10.3115/1620959.1620962.

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Perry, MIke. "Stat-Maps." In Proceedings of the First Scientific Meeting of the IASE. International Association for Statistical Education, 1993. http://dx.doi.org/10.52041/srap.93106.

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STAT-MAPS, "Statistics-Materials and Activities for Problem Solving", is a four year project (1991-94) in the Department of mathematical Sciences, Appalachian State University, USA. Funded by the National Science Foundation, The STAT-MAPS project is developing curriculum and materials for students in grades 9-12 (ages 15-17), The STAT-MAPS curriculum is giving attention to students with a broad range of abilities and interests, not just the college bound one or the advanced students who have a special interest in science or mathematics.
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"Authors Stat." In 2022 11th International Conference on Modern Circuits and Systems Technologies (MOCAST). IEEE, 2022. http://dx.doi.org/10.1109/mocast54814.2022.9837528.

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Liu, Xuan, Songhua Xing, Murali Uppala, and Arun Hampapur. "STAT: Spatio-Temporal Analytics Toolkit." In SPIE Defense, Security, and Sensing, edited by Matthew F. Pellechia, Richard Sorensen, Shiloh L. Dockstader, Rudy G. Benz II, and Bernard V. Brower. SPIE, 2011. http://dx.doi.org/10.1117/12.886677.

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Schield, Milo. "Offering stat 102: social statistics for decision makers." In Promoting Understanding of Statistics about Society. International Association for Statistical Education, 2016. http://dx.doi.org/10.52041/srap.16605.

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Statistical educators should support offering three introductory statistics courses: STAT 100 (Statistical Literacy for non-quantitative majors), STAT 101 (Traditional inferential statistics) and STAT 102 (Social statistics for decision makers). The support for the STAT 102 claim includes the needs of most students taking introductory statistics, the different kinds of decisions being made, the growing importance of big data, the limited amount of free time in the current STAT 101 course, the 2016 update to the GAISE guidelines, the importance of confounding in influencing statistical associat
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Shah, Dharambhai, and Tanish Zaveri. "A Novel Geo-Stat Endmember Extraction Algorithm." In TENCON 2019 - 2019 IEEE Region 10 Conference (TENCON). IEEE, 2019. http://dx.doi.org/10.1109/tencon.2019.8929562.

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Marr, James C. "SIM-Planetquest Mission: Overview and Current Stat..." In 56th International Astronautical Congress of the International Astronautical Federation, the International Academy of Astronautics, and the International Institute of Space Law. American Institute of Aeronautics and Astronautics, 2005. http://dx.doi.org/10.2514/6.iac-05-a3.1.04.

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Reports on the topic "STAT"

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Indset, Marthe, Jan Erling Klausen, Geir Møller, Eivind Smith, and Hilde Hatleskog Zeiner. Likeverdighet mellom stat og kommunesektor. By- og regionforskningsinstituttet NIBR, 2012. http://dx.doi.org/10.7577/nibr/samarbeidsrapport/2012/3.

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Liu, Xiaoyue Cathy, Qian Zuo, Shenruoyang Na, et al. Social-Transportation Analytic Toolbox (STAT) for Transit Networks. Transportation Research and Education Center (TREC), 2019. http://dx.doi.org/10.15760/trec.229.

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Brazaitis, Michael P. Wireless Communication of STAT Radiology Reporting Pilot Study. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada612166.

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Brooks-Kayal, Amy, and Bret Smith. JaK/STAT Inhibition to Prevent Post-Traumatic Epileptogenesis. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada612534.

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Smith, Bret N. JaK/STAT Inhibition to Prevent Post-Traumatic Epileptogenesis. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada613987.

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Brooks-Kayal, Amy, Lauren Frey, and Bret N. Smith. JaK/STAT Inhibition to Prevent Post-Traumatic Epileptogenesis. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada614126.

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Smith, Bret N. JaK/STAT Inhibition to Prevent Post-Traumatic Epileptogenesis. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada568150.

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Brooks-Kayal, Amy. Jak/STAT Inhibition to Prevent Post-Traumatic Epileptogenesis. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada568663.

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Smith, Bret N. JaK/STAT Inhibition to Prevent Post-Traumatic Epileptogenesis. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada586062.

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Reddy, Premkumar. Role of STAT-3 in ER- Breast Tumors. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada390722.

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