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Journal articles on the topic 'Statens Serum Institut'

Author: Grafiati

Published: 27 July 2024

Last updated: 31 July 2025

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1

Blom, Marianne, Aase Meyer, Peter Gerner-Smidt, Knud Gaarslev, and Frank Espersen. "Evaluation of Statens Serum Institut Enteric Medium for Detection of Enteric Pathogens." Journal of Clinical Microbiology 37, no. 7 (1999): 2312–16. http://dx.doi.org/10.1128/jcm.37.7.2312-2316.1999.

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The efficacy of the Statens Serum Institut (SSI) enteric medium for isolation and direct identification of enteric pathogens was evaluated. Six different biochemical reactions can be read by using the SSI enteric medium, allowing direct identification of a range of enteric pathogens. All 248 gram-negative bacterial species that were tested grew on the SSI enteric medium. Only 10 of 248 bacteria (4%) showed discrepant results in the biochemical reactions, and none of these were enteric pathogens. Forty-three of 47 enteric pathogens (92%) produced identical rates of semiquantitative growth on th

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2

Shigoli, Peter, Gunturu Revathi, Elusah Juliet, and Kimang'a Nyerere. "Performance of Statens Serum Institut Enteric Medium for Detection of Enteric Pathogens in Stool in Routine Laboratory Diagnostics." Universal Journal of Clinical Medicine 3, no. 2 (2015): 11–14. http://dx.doi.org/10.13189/ujcm.2015.030201.

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3

Bratcher, P. E., and M. H. Nahm. "Cross-Reactivity of Current Serogroup 6 Factor Sera from Statens Serum Institut with the Recently Described Pneumococcal Serotype 6D." Journal of Clinical Microbiology 48, no. 8 (2010): 3044–45. http://dx.doi.org/10.1128/jcm.00839-10.

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4

LIND, I., and L. BERTHELSEN. "Epidemiology of meningococcal disease in Denmark 1974–1999: contribution of the laboratory surveillance system." Epidemiology and Infection 133, no. 2 (2004): 205–15. http://dx.doi.org/10.1017/s0950268804003413.

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The Danish meningococcal disease laboratory surveillance system was established in 1974, based on close collaboration between local Departments of Clinical Microbiology and the Reference Laboratory at Statens Serum Institut. The completeness of the clinical notification system integrated with the laboratory surveillance system has been estimated to be more than 95%. Overall 4257 (79%) of 5356 cases of meningococcal disease notified during 1974–1999 were confirmed by culture of Neisseria meningitidis. The proportion of culture-confirmed cases ranged from 70% in 1989 to 89% in 1980. Only 26 pati

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Risum, Malene, Mai-Britt Vestergaard, Ulla Møller Weinreich, Marie Helleberg, Nadja Hawwa Vissing, and René Jørgensen. "Therapeutic Drug Monitoring of Isavuconazole: Serum Concentration Variability and Success Rates for Reaching Target in Comparison with Voriconazole." Antibiotics 10, no. 5 (2021): 487. http://dx.doi.org/10.3390/antibiotics10050487.

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Isavuconazole (ISZ) is used in the treatment of aspergillosis and mucormycosis. The purpose of this study was to evaluate the therapeutic drug monitoring (TDM) of ISZ samples from a clinical setting performed at Statens Serum Institut. Materials/methods: Isavuconazole serum concentrations were determined by fluorescent detection on a UHPLC. Serum-ISZ (s-ISZ) results were included and compared to those of serum-voriconazole (s-VRZ) in a 33 month period from March 2017. Clinical data were obtained for patients receiving ISZ. The therapeutic range was initially 2–10 mg/L, but was adjusted to 2–5

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Roglić, Srđan, Drusia Dickson, Branko Miše, et al. "Successful Treatment of Disseminated Bacillus Calmette-Guérin Disease in an HIV-Infected Child with a Linezolid-Containing Regimen." Case Reports in Infectious Diseases 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/1528981.

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Upon HIV infection diagnosis, an 8-month-old boy was transferred for evaluation of worsening respiratory distress requiring mechanical ventilation.Pneumocystis jiroveciipneumonia (PCP) was diagnosed; the boy also had a nonhealing ulcer at the site of vaccination with Statens Serum Institut (Danish strain) Bacillus Calmette-Guérin (BCG) vaccine and associated axillary lymphadenopathy. PCP treatment resulted in weaning from mechanical ventilation. Antimycobacterial treatment was immediately attempted but was discontinued because of hepatotoxicity. Over several months, he developed splenic lesion

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Henson, Dawn, Jaap van Dissel, Simone Joosten, et al. "Vaccination with a Hybrid 1 (H1) fusion protein combined with a liposomal adjuvant (CAF01) induced antigen specific T-cells 3 years post vaccination in a human clinical trial. (VAC7P.971)." Journal of Immunology 192, no. 1_Supplement (2014): 141.16. http://dx.doi.org/10.4049/jimmunol.192.supp.141.16.

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Abstract Approximately one third of the world’s population is infected with Mycobacterium tuberculosis. Developing novel vaccines to protect against pulmonary tuberculosis is a public health priority. In this study, a Hybrid 1 (H1) subunit vaccine containing a recombinant fusion protein of Ag85B and ESAT-6 was paired with a two-component CAF01 liposomal adjuvant system developed and manufactured by Statens Serum Institut. A phase I clinical study was performed to evaluate H1:CAF01 in healthy non-BCG vaccinated adult male and female subjects between the ages of 18 and 55 years old. The subjects

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Honda-Okubo, Yoshikazu, Jeremy Baldwin, and Nikolai Petrovsky. "Advax-CpG Adjuvant Provides Antigen Dose-Sparing and Enhanced Immunogenicity for Inactivated Poliomyelitis Virus Vaccines." Pathogens 10, no. 5 (2021): 500. http://dx.doi.org/10.3390/pathogens10050500.

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Global immunization campaigns have resulted in a major decline in the global incidence of polio cases, with wild-type poliovirus remaining endemic in only two countries. Live oral polio vaccine (OPV) played a role in the reduction in polio case numbers; however, the risk of OPV developing into circulating vaccine-derived poliovirus makes it unsuitable for eradication programs. Trivalent inactivated polio virus (TIPV) vaccines which contain formalin-inactivated antigens produced from virulent types 1, 2 and 3 reference polio strains grown in Vero monkey kidney cells have been advocated as a rep

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9

Becker, Ulrich, Carsten Ehrhardt, Marc Schneider, et al. "A Comparative Evaluation of Corneal Epithelial Cell Cultures for Assessing Ocular Permeability." Alternatives to Laboratory Animals 36, no. 1 (2008): 33–44. http://dx.doi.org/10.1177/026119290803600106.

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The purpose of this study was to evaluate the potential value of different epithelial cell culture systems as in vitro models for studying corneal permeability. Transformed human corneal epithelial (HCE-T) cells and Statens Serum Institut rabbit corneal (SIRC) cells were cultured on permeable filters. SkinEthic human corneal epithelium (S-HCE) and Clonetics human corneal epithelium (C-HCE) were received as ready-to-use systems. Excised rabbit corneas (ERCs) and human corneas (EHCs) were mounted in Ussing chambers, and used as references. Barrier properties were assessed by measuring transepith

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10

CARRILLO, CATHERINE D., ADAM G. KOZIOL, AMIT MATHEWS, et al. "Comparative Evaluation of Genomic and Laboratory Approaches for Determination of Shiga Toxin Subtypes in Escherichia coli." Journal of Food Protection 79, no. 12 (2016): 2078–85. http://dx.doi.org/10.4315/0362-028x.jfp-16-228.

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ABSTRACT The determination of Shiga toxin (ST) subtypes can be an important element in the risk characterization of foodborne ST-producing Escherichia coli (STEC) isolates for making risk management decisions. ST subtyping methods include PCR techniques based on electrophoretic or pyrosequencing analysis of amplicons and in silico techniques based on whole genome sequence analysis using algorithms that can be readily incorporated into bioinformatics analysis pipelines for characterization of isolates by their genetic composition. The choice of technique will depend on the performance character

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Vrioni, G., M.-V. Kazani, C. Tsiamis, H. Papadogeorgakis, and A. Tsakris. "Evaluation of a multiplex-PCR-based method for the rapid identification of dermatophytes in nail specimens from patients with suspected onychomycosis." ACTA MICROBIOLOGICA HELLENICA 62, no. 1 (2017): 25–33. https://doi.org/10.5281/zenodo.10066826.

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Onychomycosis is a common nail disorder that can mimic other nail conditions. Fungal infection of the nail requires a long term systemic antifungal treatment, which means that accurate diagnosis is mandatory. The standard procedure for fungal detection in nails requires direct microscopy and culture, but is still time consuming with high rates of false-negative results. Molecular assays offer an alternative diagnostic process that might resolve problems of the standard methodology. The aim of the current study was to evaluate a direct multiplex-PCR method in rapidly identifying dermatophytes i

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Jiang, Fan, Tiehui Sun, Peng Cheng, Jie Wang, and Wenping Gong. "A Summary on Tuberculosis Vaccine Development—Where to Go?" Journal of Personalized Medicine 13, no. 3 (2023): 408. http://dx.doi.org/10.3390/jpm13030408.

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Background: Tuberculosis (TB) is an old infectious disease caused by Mycobacterium tuberculosis infection. Vaccination is the most effective way to prevent and control TB. However, there is relatively little literature that systematically analyzes the progress of new TB vaccine research from a bibliometric perspective. This study was conducted to examine the development of TB vaccines over the past 20 years and to identify research priorities and directions for the future. Methods: The Science Citation Index Expanded (SCI-E) of the Web of Science Core Collection (WOSCC) database was selected t

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Swarthout, Todd D., Andrea Gori, Naor Bar-Zeev, et al. "Evaluation of Pneumococcal Serotyping of Nasopharyngeal-Carriage Isolates by Latex Agglutination, Whole-Genome Sequencing (PneumoCaT), and DNA Microarray in a High-Pneumococcal-Carriage-Prevalence Population in Malawi." Journal of Clinical Microbiology 59, no. 1 (2020): e02103-20. http://dx.doi.org/10.1128/jcm.02103-20.

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ABSTRACTAccurate assessment of the serotype distribution associated with pneumococcal colonization and disease is essential for evaluating and formulating pneumococcal vaccines and for informing vaccine policy. For this reason, we evaluated the concordance between pneumococcal serotyping results by latex agglutination, whole-genome sequencing (WGS) with PneumoCaT, and DNA microarray for samples from community carriage surveillance in Blantyre, Malawi. Nasopharyngeal swabs were collected according to WHO recommendations between 2015 and 2017 by using stratified random sampling among study popul

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Carter, Emma, Ben Morton, Dima ElSafadi, et al. "A feasibility study of controlled human infection with intradermal Bacillus Calmette–Guérin (BCG) injection: Pilot BCG controlled human infection model." Wellcome Open Research 8 (October 2, 2023): 424. http://dx.doi.org/10.12688/wellcomeopenres.19811.1.

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Tuberculosis (TB) caused 1.5 million deaths in 2020, making it the leading infectious killer after COVID-19. Bacille Calmette-Guerin (BCG) is the only licensed vaccine against TB but has sub-optimal efficacy against pulmonary TB and reduced effectiveness in regions close to the equator with high burden. Efforts to find novel vaccines are hampered due to the need for large-scale, prolonged, and costly clinical trials. Controlled human infection models (CHIMs) for TB may be used to accelerate vaccine development by ensuring only the most promising vaccine candidates are selected for phase 3 tria

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Carter, Emma, Ben Morton, Dima ElSafadi, et al. "A feasibility study of controlled human infection with intradermal Bacillus Calmette–Guérin (BCG) injection: Pilot BCG controlled human infection model." Wellcome Open Research 8 (June 5, 2024): 424. http://dx.doi.org/10.12688/wellcomeopenres.19811.2.

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Tuberculosis (TB) caused 1.5 million deaths in 2020, making it the leading infectious killer after COVID-19. Bacille Calmette-Guerin (BCG) is the only licensed vaccine against TB but has sub-optimal efficacy against pulmonary TB and reduced effectiveness in regions close to the equator with high burden. Efforts to find novel vaccines are hampered due to the need for large-scale, prolonged, and costly clinical trials. Controlled human infection models (CHIMs) for TB may be used to accelerate vaccine development by ensuring only the most promising vaccine candidates are selected for phase 3 tria

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16

Rangel-Frausto, M. Sigfrido, Samuel Ponce-de-León-Rosales, Claudia Martinez-Abaroa, and Kaare Hasløv. "Tuberculosis and Tuberculin Quality: Best Intentions, Misleading Results." Infection Control & Hospital Epidemiology 22, no. 08 (2001): 481–84. http://dx.doi.org/10.1086/501937.

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Abstract Objective: To compare the performance of three purified protein derivative (PPD) formulations: Tubersol (Connaught); RT23, Statens Serum Institut (SSI); and RT23, Mexico, tested in Mexican populations at low and high risk for tuberculosis (TB). Design: A double-blinded clinical trial. Setting: A university hospital in Mexico City. Participants: The low-risk population was first or second-year medical students with no patient contact; the high-risk population was healthcare workers at a university hospital. Methods: Each of the study subjects received the three different PPD preparatio

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Aarestrup, F. M., and N. F. Friis. "Antimicrobial susceptibility testing of Mycoplasma hyosynoviae isolated from pigs during 1968 to 1971 and during 1995 and 19961This study is a part of the Danish Integrated Antimicrobial Resistance Monitoring and Research Programme (DANMAP) conducted in collaboration between Statens Serum Institut, the National Food Agency of Denmark and the Danish Veterinary Laboratory and funded jointly by the Danish Ministry of Health and the Danish Ministry of Agriculture and Fisheries.1." Veterinary Microbiology 61, no. 1-2 (1998): 33–39. http://dx.doi.org/10.1016/s0378-1135(98)00169-2.

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18

S., N. Upadhyay, Lal C., Bhardwaj R., Chaturvedi S., and K. Chaudhury N. "Interaction of spermine with DNA, vitamin C and bovine serum albumin in the unirradiated and gamma irradiated states." Journal of Indian Chemical Society Vol. 83, Apr 2006 (2006): 379–82. https://doi.org/10.5281/zenodo.5836524.

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Institute of Nuclear Medicine & Allied Sciences, Brig. S. K. Mazumdar Road, Delhi-11 0 054, India E-mail: snu@inmas.org <em>Manuscript received 20 July 2004, revised 2 December 2005, accepted 15 December 2005</em> Structural deformability of spermine with radiation dose (maximum 10 Gy) has been proved. Complex formation of spermine with DNA, vitamin C and BSA took place. Calibration and radiation-induced absorption changes in spermine by ninhydrin reagent has been followed quantitatively. Interaction of vitamin C with DNA and their radiation-induced changes have been reported.Interaction o

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Cordtz, R., S. Kristensen, R. Westermann, et al. "OP0173 INCIDENCE OF COVID-19 INFECTION AND HOSPITALISATION ACCORDING TO VACCINATION STATUS AND DMARD TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS: A NATIONWIDE MATCHED COHORT STUDY FROM DENMARK." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 114–15. http://dx.doi.org/10.1136/annrheumdis-2022-eular.349.

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BackgroundPatients with rheumatoid arthritis (RA) may have impaired immunogenicity to COVID-19 vaccines.ObjectivesTo investigate the incidence of COVID-19 infection and hospitalisation in unvaccinated and vaccinated patients with RA compared with matched individuals; and secondarily in patients with RA according to DMARD treatment.MethodsDanish nationwide matched cohort study from January to October 2021. Patients with RA were identified in DANBIO and matched 1:20 with individuals from the general population on age, sex, and vaccination status (month and exact type of vaccination). Primary and

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Usman Aslam, Muhammad Ubaidullah Khan, Sadia Chiragh, Abdul Karim, and Mushtaq Ahmed. "Effect of Atorvastatin Alone and in Combination with Aspirin on Uric Acid Handling of Normal Rats." Proceedings 35, no. 2 (2021): 78–82. http://dx.doi.org/10.47489/pszmc784-35-2-78-82.

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Introduction: Low doses of aspirin and statins are usually given in conjunction to patients with coronary artery disease. Aspirin at low doses is known to cause hyperuricemia in these patients which can further worsen their condition, while statins can theoretically counteract this effect. However, this interaction needs to be tested. Aims & Objectives: To estimate the effect of atorvastatin and low dose of aspirin alone and in combination on serum uric acid level and urinary uric acid excretion in normal rats. Place and duration of study: Post Graduate Medical Institute, Lahor

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Singh, Priyanka, and Aanchal Kakkar. "COVID-19-associated pulmonary aspergillosis." Journal of Current Research in Scientific Medicine 9, no. 2 (2023): 173–76. http://dx.doi.org/10.4103/jcrsm.jcrsm_32_23.

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Abstract Invasive pulmonary aspergillosis (IPA) is now been recognized as a possible secondary infection affecting COVID-19 recovery and increasing mortality. It can be explained due to factors such as direct epithelial injury, hypercoagulable and hyperinflammatory states, and the use of immunosuppressive treatment. We managed five such cases in a post-COVID intensive care unit facility at a tertiary care institute in North India. All patients had high oxygen demand, positive serum galactomannan (GM) index, and significant chest X-ray changes. All patients showed an initial improvement after r

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Memon, A. R., M. Akram, U. Bhatti, A. S. Khan, K. Rani, and H. Riaz. "Vitamin B3 (Niacin) in Diet Act as Protective Negotiator for Development of Myocardial Infarction." Pakistan Journal of Medical and Health Sciences 15, no. 5 (2021): 1127–29. http://dx.doi.org/10.53350/pjmhs211551127.

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Background: Vitamin B3 (Niacin) is known to decrease LDL‐cholesterol, and triglycerides, and increase HDL‐cholesterol levels. The evidence of benefits with niacin monotherapy or add‐on to statin‐based therapy is controversial. Aim: To determine the effects of vitamin B3 with statins on lipid profile of patients of angina pectoris with dyslpidemia. Study Design: Randomized control trial study. Place and Duration of Study: Department of Biochemistry, Shaikha Fatima Institute of Nursing & Health Sciences (SFINHS), Lahore with collaboration of Cardiology OPD of Shaikh Zayed Hospital Lahore fro

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Akhter, SP, S. Khan, T. Mehdi, Md Nasiruddin, and FH Mollah. "Renal Function Before and After Coronary Artery Bypass Grafting (CABG): Off Pump vs. On Pump." Bangladesh Journal of Medical Biochemistry 3, no. 2 (2013): 36–41. http://dx.doi.org/10.3329/bjmb.v3i2.13809.

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Coronary Artery Bypass Grafting (CABG) is associated with a significant morbidity and mortality and several factors have been identified as predictive of complications. These include renal dysfunction and in particular renal replacement therapy. More than 600,000 coronary artery graft procedures are performed annually in the United States. Of those patients with coronary arterial disease 10% patients undergo CABG surgery. To explore the association of renal function between off-pump and on-pump-CABG. To evaluate the degree of impairment of renal function in on-pump, 80 patients (off-pump group

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Goodrich, Erin L., and Julie L. Webb. "Complete Blood Count and Biochemistry Reference Intervals for Healthy Adult Donkeys in the United States." Animals 14, no. 14 (2024): 2018. http://dx.doi.org/10.3390/ani14142018.

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Previous hematologic and serum biochemistry reference interval (RI) values have been established for donkeys in various geographic regions, life-stages, or for specific donkey breeds. The last extensive investigation establishing RIs for adult donkeys in the United States (U.S.) was published over three decades ago. We aimed to establish updated robust RIs using a reference population of apparently healthy adult donkeys from across the U.S. Standard sized (n = 102), miniature (n = 17), and mammoth (n = 1) donkeys from four different states were enrolled, with 20% of the study population includ

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Chellamuthu, Lalithambigai, Sinthu S. Sarathamani, and Abhijit V. Boratne. "A perspective on the widening gap between Covishield vaccine doses in India." Indian Journal of Community Health 33, no. 3 (2021): 541–42. http://dx.doi.org/10.47203/ijch.2021.v33i03.026.

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The Oxford University-AstraZeneca’s vector-based vaccine called Covishield (ChAdOx1 nCoV- 19 Vaccine) is being manufactured and distributed by Serum Institute of India (SII). National roll out of this vaccine was in a phased manner starting from 16th January 2021. At present, many states are facing shortage of vaccines. Government of India kept changing its policy on dosing gap of Covishield vaccine based on researches. The latest recommendation citing “real-life evidence” from the UK is to extend the two doses of Covishield to 12-16 weeks. This reasonable approach will not only a breathing sp

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Nagpal, Dheeraj, Gauri S Shah, Shyam Kafle, and Madhav Lamsal. "Electrolyte disturbances in children admitted at pediatric intensive care unit in BP Koirala institute of health sciences: A cross-sectional observational study." Journal of Pediatrics & Neonatal Care 15, no. 1 (2025): 1–5. https://doi.org/10.15406/jpnc.2025.15.00572.

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Objective: To investigate the types and clinical implications of electrolyte disturbances, specifically focusing on serum sodium, potassium, and calcium levels, in critically ill pediatric patients admitted to the Pediatric Intensive Care Unit (PICU) at B.P. Koirala Institute of Health Sciences (BPKIHS). Methods: This cross-sectional study included 188 critically ill children admitted to the PICU. Serum levels of sodium, potassium, and calcium were measured, and electrolyte disturbances were categorized. Data on baseline demographics, underlying conditions, and organ systems involved, and clin

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Zhu, Yong, Neha Jain, Vipra Vanage, Norton Holschuh, and Jessica Smith. "Association Between Ready-to-Eat Cereal Consumption and Serum Level of 25-hydroxyvitamin D in US Children and Adults, NHANES 2013–2014." Current Developments in Nutrition 4, Supplement_2 (2020): 1514. http://dx.doi.org/10.1093/cdn/nzaa061_142.

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Abstract Objectives Previous studies have shown that consumption of ready-to-eat (RTE) cereal is associated with higher dietary intake of vitamin D; however, little is known about the association between RTE cereal consumption and vitamin D status measured by the serum biomarker, 25-hydroxyvitamin D. The study was conducted to examine association between consumption of RTE cereal and serum level of 25-hydroxyvitamin D, the clinical biomarker for vitamin D status in children and adults in the United States. Methods Children aged 1–18 years old (N = 2553) and adults aged 19 years or older (N = 4

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Kashyapa, Hrishikesh, Rupali Bajrang Jadhav, and Anuradha Deshkar. "Comparison of the efficacy and safety of rosuvastatin versus atorvastatin in reduction of low density lipoprotein cholesterol in patients of type 2 diabetes mellitus with dyslipidemia." International Journal of Research in Medical Sciences 6, no. 8 (2018): 2671. http://dx.doi.org/10.18203/2320-6012.ijrms20183249.

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Background: Approximately 80% of deaths in diabetic patients are attributable to cardiovascular disease (CVD), which in turn is highly correlated with diabetic dyslipidemia. Statins are drug of choice for raised LDL-C in treating dyslipidemia. The present study compares the efficacy and safety of rosuvastatin against commonly used atorvastatin in patients of type 2 diabetes mellitus with dyslipidemia, so as to guide the present treatment strategies in the management of the same in Indian population.Methods: The study was a single blinded study conducted in a district level tertiary care hospit

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Hall, Breese. "A Single Shot at Salmonella typhi: A New Typhoid Vaccine With Pediatric Advantages." Pediatrics 96, no. 2 (1995): 348–50. http://dx.doi.org/10.1542/peds.96.2.348.

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A new typhoid vaccine has just been licensed, which is the third typhoid vaccine available in the United States.1,2 Since publication of the 1994 Red Book occurred before licensure, this new vaccine is not included. The recommendations concerning the two previously licensed typhoid vaccines in the 1994 Red Book remain unchanged.3 The new vaccine, Typhoid Vi, is manufactured by Pasteur Mérieux (Marnes-La-Coquette, France). This parenteral vaccine is composed of the purified Vi (virulence) antigen, which is the capsular polysaccharide (ViCPS) of Salmonella typhi. The two previously licensed typ

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Mohammed, Yousif Abdelhameed, Ameer M. Dafalla, Dafalla O. Abuidris, et al. "Association of Body Mass Index with Serum Vitamin D and PSA Levels among Sudanese Prostate Cancer Patients." Journal of Drug Delivery and Therapeutics 11, no. 6 (2021): 1–5. http://dx.doi.org/10.22270/jddt.v11i6.5029.

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Background: Prostate cancer is the second most common cancer in men worldwide and the second leading cause of cancer deaths in men in the United States. Obesity has been consistently associated with lower 25-hydroxyvitamin D (25(OH)D) concentrations. Objectives: This cross-sectional study aimed to evaluate the serum vitamin D and PSA levels in Sudanese Obese and Non-Obese prostate cancer (PCa) attending the National Cancer Institute. Patients and Methods: Eighty six prostate cancer patients were included in this study, they were identified by clinical examination, histopathology an

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Malacova, Eva, Peihua (Rachel) Cheang, Eleanor Dunlop, et al. "Prevalence and predictors of vitamin D deficiency in a nationally representative sample of adults participating in the 2011–2013 Australian Health Survey." British Journal of Nutrition 121, no. 8 (2019): 894–904. http://dx.doi.org/10.1017/s0007114519000151.

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AbstractVitamin D deficiency is recognised as a public health problem globally, and a high prevalence of deficiency has previously been reported in Australia. This study details the prevalence of vitamin D deficiency in a nationally representative sample of Australian adults aged ≥25 years, using an internationally standardised method to measure serum 25-hydroxyvitamin D (25(OH)D) concentrations and identifies demographic and lifestyle factors associated with vitamin D deficiency. We used data from the 2011–2013 Australian Health Survey (n 5034 with complete information on potential predictors

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Mohammed, Muaath Ahmed, Ibrahim Abdelrhim Ali, Abdarahiem Alborai Abeadalla, and Omer Abdelaziz Musa. "Reference intervals for serum creatinine and urea in the adult western Sudanese population." South Sudan Medical Journal 17, no. 1 (2024): 6–10. http://dx.doi.org/10.4314/ssmj.v17i1.2.

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Introduction: Serum creatinine and urea levels are affected by numerous factors such as ethnicity, environment, age, sex, and anthropometric measurements. The Clinical and Laboratory Standards Institute (CLSI) recommends that each laboratory should establish its own reference intervals for biochemistry and haematology. There are no local reference intervals for serum creatinine and blood urea in Sudan; instead, intervals derived from worldwide research are used. The purpose of this study was to determine the blood urea and serum creatinine reference intervals for healthy adults in the Western

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Goguet, Emilie, Carol Weiss, Cara Olsen, et al. "Correlates of immunity in SARS-CoV-2 post-vaccine infections in the Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) Study." Journal of Immunology 210, no. 1_Supplement (2023): 159.02. http://dx.doi.org/10.4049/jimmunol.210.supp.159.02.

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Abstract Background: We sought to determine pre-infection correlates of immunity against SARS-CoV-2 post-vaccine infections. Methods: Serum and saliva samples from 176 BNT162b2-vaccinated adults in the Prospective Assessment of SARS-CoV-2 Seroconversion study were collected between October and December 2021 and assessed for serum and saliva levels of WT SARS-CoV-2 Spike (S)-specific IgG and IgA antibodies using a microsphere-based multiplex immunoassay. Serum samples were also assessed for neutralization activity against D614G, Delta (617.2), and Omicron BA.1 and BA.1.1 variants using a lentiv

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Nham, Eliel, A.-Yeung Jang, Hyun Jung Ji, et al. "Development and Validation of an Enzyme-Linked Immunosorbent Assay-Based Protocol for Evaluation of Respiratory Syncytial Virus Vaccines." Viruses 16, no. 6 (2024): 952. http://dx.doi.org/10.3390/v16060952.

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Recently, respiratory syncytial virus (RSV) vaccines based on the prefusion F (pre-F) antigen were approved in the United States. We aimed to develop an enzyme-linked immunosorbent assay (ELISA)-based protocol for the practical and large-scale evaluation of RSV vaccines. Two modified pre-F proteins (DS-Cav1 and SC-TM) were produced by genetic recombination and replication using an adenoviral vector. The protocol was established by optimizing the concentrations of the coating antigen (pre-F proteins), secondary antibodies, and blocking buffer. To validate the protocol, we examined its accuracy,

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HA, Krishnamurthy, Bharathi S, and Roja GT. "The predictive significance of ratio between white blood cells count and serum albumin in assessing the functional outcome of acute ischemic stroke." Journal of Medical and Scientific Research 11, no. 2 (2023): 119–24. http://dx.doi.org/10.17727/jmsr.2023/11-23.

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Introduction: The acute ischemic infarction is associated with significant damage to brain parenchyma, where the high degree of acute inflammation is found. This work aimed to study the predictive value of ratio between blood WBCs and serum albumin levels in assessing the functional outcome in subjects with acute ischemic stroke. Materials and methods: A prospective observational study was conducted on 223 subjects from February 2022 to August 2022 at K.R. Hospital, Mysore. The data collected from patients of acute ischemic stroke, with the onset of stroke within 24 hours. Severity of stroke w

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Agudelo Zapata, Yessica, Jonathan Alexander Cortés-Vásquez, Andrés Felipe Linares Vaca, et al. "papel de la vitamina D en la gestación y la preeclampsia: de la biología molecular a la clínica." Revista Colombiana de Endocrinología, Diabetes & Metabolismo 3, no. 2 (2017): 22–36. http://dx.doi.org/10.53853/encr.3.2.30.

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Los niveles séricos de vitamina D bajos se han asociado con un riesgo elevado de preeclampsia, una de las principales causas de mortalidad materna en Colombia y el mundo. La asociación parte del papel de la vitamina D en la inflamación y de su relación con el eje renina-angiotensina-aldosterona. El Instituto de Salud de los Estados Unidos sugiere que la vitamina D debe suplementarse de forma rutinaria durante el control prenatal; sin embargo, la Organización Mundial de la Salud, respaldada en medicina basada en la evidencia, sugiere la no suplementación de rutina de esta vitamina. En Colombia,

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NEOGI, TUHINA, ROBERT TERKELTAUB, R. CURTIS ELLISON, STEVEN HUNT, and YUQING ZHANG. "Serum Urate Is Not Associated with Coronary Artery Calcification: The NHLBI Family Heart Study." Journal of Rheumatology 38, no. 1 (2010): 111–17. http://dx.doi.org/10.3899/jrheum.100639.

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Objective.Urate may have effects on vascular remodeling and atherosclerosis. We had shown an association between serum uric acid (SUA) and carotid atherosclerotic plaques. Inflammation and vascular remodeling in atherosclerosis promote coronary artery calcification (CAC), a preclinical marker for atherosclerosis. Here, we examined whether SUA is associated with CAC, using the same study sample and methods as for our previous carotid atherosclerosis study.Methods.The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart dis

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Martić, Nikola, Dragan Zečević, Milena Đurđević, et al. "Comparative analysis of the use of lipid modifying agents in the Republic of Serbia and Nordic countries in the period 2015-2017." Hospital Pharmacology - International Multidisciplinary Journal 7, no. 3 (2020): 966–75. http://dx.doi.org/10.5937/hpimj2003966m.

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Introduction: Cardiovascular diseases are the leading cause of death both in Serbia and in the rest of the world. It has been shown that as many as 80% of them are preventable. Control of serum lipid levels is one of the most important tasks of cardiovascular diseases prevention. Aim: The aim of the study was to analyze the use of serum lipid-modifying drugs in Serbia, Norway and Finland in the period 2015-2017. Methods: Data on drugs use during 2015, 2016 and 2017 were taken from the official websites of national drug regulatory authorities: the Serbian Medicines and Medical Devices Agency, t

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Ravi Kant, Shashi Kala Kumari, Rakesh Sinha, Ranjeet Kumar, and Arun Kumar. "Association of inflammatory markers, serum ferritin and high sensitive C reactive protein, with HbA1c and dyslipidemia in male patients of type 2 diabetes mellitus." Asian Journal of Medical Sciences 15, no. 4 (2024): 78–83. http://dx.doi.org/10.3126/ajms.v15i4.61885.

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Background: Diabetes mellitus (DM) is a common metabolic disorder affecting insulin secretion, insulin sensitivity, or both, resulting in hyperglycemia. As it progresses, almost all systems including cardiovascular, nervous, renal, etc. are involved eventually manifesting as several health-related complications. As all the systems of the human body work in harmony with each other, development of insulin resistance, dyslipidemia, and setting in of chronic inflammatory states evidenced by the rise in inflammatory markers are interrelated. Aims and Objectives: The aim of this study was to establi

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Cetin Sanlialp, Sara, Gokay Nar, and Rukiye Nar. "Relationship between circulating serum omentin-1 levels and nascent metabolic syndrome in patients with hypertension." Journal of Investigative Medicine 70, no. 3 (2021): 780–85. http://dx.doi.org/10.1136/jim-2021-002071.

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The prevalence of metabolic syndrome (MetS) is more common in patients with hypertension and is associated with an increased risk of target organ damage and/or cardiovascular disease (CVD). Omentin-1 is a beneficial adipokine considered to play a role in MetS and MetS-related states such as obesity, diabetes, and coronary artery disease. The aim of this study was to determine the relationship between circulating omentin-1 levels and MetS uncomplicated by diabetes or CVD (nascent MetS) in patients with hypertension. In this study, 110 patients (54 men, 49%; average age: 49.72±11.32 years) treat

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Hendry, Alexandra J., Aditi Dey, Frank H. Beard, Gulam Khandaker, Richard Hill, and Kristine K. Macartney. "Adverse events following immunisation with bacille Calmette-Guérin vaccination: baseline data to inform monitoring in Australia following introduction of new unregistered BCG vaccine." Communicable Diseases Intelligence 40 (December 1, 2016): 470–74. https://doi.org/10.33321/cdi.2016.40.52.

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In recent years there has been a global shortage of bacille Calmette-Guérin (BCG) vaccine and, from September 2012, unregistered vaccines have needed to be used in Australia (a Danish product initially until the end of 2015, and a Polish product used in some jurisdictions from early 2016). We examined rates and types of adverse events following immunisation (AEFI) with BCG vaccine reported to the Therapeutic Goods Administration between 2009 and 2014 in children aged less than 7 years. Reporting rates of AEFI with BCG vaccine increased from 87 per 100,000 doses (registered Sanofi Pasteur produ

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Kraus, Frank Bernhard, Marija Kocijancic, Alexander Kluttig та Beatrice Ludwig-Kraus. "Test validation, method comparison and reference range for the measurement of β-hydroxybutyrate in peripheral blood samples". Biochemia medica 30, № 1 (2020): 118–27. http://dx.doi.org/10.11613/bm.2020.010707.

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Introduction: The measurement of β-hydroxybutyrate (βOHB) concentrations is a corner stone of the diagnosis of diabetic ketoacidosis and other ketonic states. The aim of this study was to perform a validation of a peripheral blood βOHB assay (Randox) on a Roche cobas c502 analyser and to establish a βOHB reference range for the validated assay. Materials and methods: Precision, linearity and limit of detection and blank (LoD, LoB) were determined according to Clinical and Laboratory Standards Institute (CLSI) EP05-A3, EP 06-A and EP17-A2 guidelines, using commercial control material and residu

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PEIXOTO, RODOLFO DE MORAES, GRACE BARBOSA DOS SANTOS, EVANDRO SANTOS AMANSO, MARIA DA CONCEIÇÃO AQUINO DE SÁ, RENATA DE MORAES PEIXOTO ARAÚJO, and MATEUS MATIUZZI DA COSTA. "ANTI-Lentivirus, Brucella abortus AND B. ovis ANTIBODIES IN SMALL RUMINANTS RAISED IN PERNAMBUCO AND BAHIA." Revista Caatinga 29, no. 2 (2016): 507–11. http://dx.doi.org/10.1590/1983-21252016v29n229rc.

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ABSTRACT: Goat and sheep production in the semi-arid northeast of Brazil has shown great economic potential. However, health problems can compromise the productivity of these animals. Given the scarcity of studies about the occurrence of these diseases, the aim of the present study was to analyze the serological diagnosis of anti-Brucella and anti-lentivirus antibodies among small ruminants in municipalities located in the Brazilian states of Bahia and Pernambuco. The samples were collected from local slaughterhouses and dairy farms. In total, 997 serum samples from animals in slaughterhouses

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Pradeep, K. Sengupta, and Chaudhuri Sudip. "Interactions of therapeutically active plant flavonols with biological targets : Insights from fluorescence spectroscopic studies." Journal of Indian Chemical Society Vol. 87, Feb 2010 (2010): 213–20. https://doi.org/10.5281/zenodo.5778388.

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Biophysics Division, Saba Institute of Nuclear Physics, l/AF, Bidhannagar, Kolkata-700 064, India <em>E-mail:</em> pradeepk.sengupta@saha.ac.in,_pradeepsinp@yahoo.co.in Fax : 91-33-23374637 Gandhi Centenary B. T. College, Habra. North 24-Parganas, West Bengal, India <em>Manuscript received 22 December 2009, accepted 29 December 2009</em> Plant flavonols have attracted much recent attention in view or their novel therapeutic properties (effective against various free radical mediated and other diseases) which make them promising alternatives to conventional therapeutic drugs. However, till date

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Ameet, H., Deependra K. Rai, Saurabh Karmakar, et al. "Bronchodilator reversibility and eosinophilic biomarkers in chronic obstructive pulmonary disease patients." Lung India 42, no. 2 (2025): 128–33. https://doi.org/10.4103/lungindia.lungindia_261_24.

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ABSTRACT Background and Objectives: Chronic Obstructive Pulmonary Disease (COPD) is now one of the top three causes of death worldwide. Recently, increased focus has been on COPD patients displaying eosinophilic inflammation and asthma-like features of bronchial hyperreactivity and bronchodilator responsiveness. The objective of the study was to measure the proportion of chronic obstructive pulmonary disease patients with bronchodilator reversibility and to compare the eosinophilic biomarkers between the bronchodilator non-reversible and reversible groups. Materials and Methods: This hospital-

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Wong, Eileen, Else Agger, Peter Andersen, and JoAnne Flynn. "Immunogenicity of TB vaccine H56 in non-human primates (VAC4P.1113)." Journal of Immunology 194, no. 1_Supplement (2015): 72.18. http://dx.doi.org/10.4049/jimmunol.194.supp.72.18.

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Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health problem. Several TB vaccine candidates are currently in various stages of development and clinical testing, including the protein subunit vaccine H56, from Statens Serum Institute (Copenhagen, Denmark). The cationic liposome adjuvant CAF09 was recently developed to enhance the CD4 and CD8 T cell response when administered with H56 vaccine. We vaccinated non-human primates (NHP) with H56 vaccine and CAF09 adjuvant by intranasal and subcutaneous routes and compared differences in immunogenicity.

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Jean de Dieu, Baziki, Bodjo S. Charles, Nick Nwankpa, et al. "Development and Evaluation of Epitope-Blocking ELISA for Detection of Antibodies against Contagious Caprine Pleuropneumonia in Goat Sera." Veterinary Sciences 6, no. 4 (2019): 82. http://dx.doi.org/10.3390/vetsci6040082.

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Enzyme linked immunosorbent assays (ELISAs) have been developed for the detection of antibodies against contagious caprine pleuropneumonia (CCPP), the causative agent of which is Mycoplasma capricolum subsp. Capripneumoniae (Mccp). The currently available commercial CCPP competitive ELISA (CCPP cELISA) kit produced and supplied by IDEXX Company (Westbrook, Maine, United States) is relatively expensive for most African laboratories. To address this issue and provide a variety of choices, a sensitive and specific blocking-ELISA (b-ELISA) test to detect antibodies against CCPP was developed. We d

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Arashi, Hiroyuki, Junichi Yamaguchi, Erisa Kawada-Watanabe, et al. "The Effects of Lipid-Lowering Therapy on Serum Eicosapentaenoic Acid to Arachidonic Acid Ratio: An HIJ-PROPER Sub-Analysis." Journal of Cardiovascular Pharmacology and Therapeutics 25, no. 6 (2020): 548–55. http://dx.doi.org/10.1177/1074248420931621.

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Background: Controversy remains regarding the influence of lipid-lowering therapy on the eicosapentaenoic acid/arachidonic acid ratio. Objective: This study aimed to clarify the effects of lipid-lowering therapy on the eicosapentaenoic acid/arachidonic acid ratio in patients with acute coronary syndrome (ACS). Methods: This was a post hoc sub-analysis of the Heart Institute of Japan-PRoper level of lipid-lowering with pitavastatin and ezetimibe in ACS study. We compared the eicosapentaenoic acid/arachidonic acid ratio changes from baseline to the 3-month follow-up after contemporary lipid-lowe

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Maqsood, Mariam, Saleha Sadeeqa, Maqsood Ahmad, and Hafsa Afzal. "Efficacy and safety of atorvastatin and rosuvastatin in ischemic heart disease patients: A prospective study." Tropical Journal of Pharmaceutical Research 18, no. 7 (2021): 1533–38. http://dx.doi.org/10.4314/tjpr.v18i7.25.

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Purpose: To compare the safety and efficacy of two commonly used statins namely; atorvastatin and rosuvastatin, and determine the efficiency of CoQ10 in the reversal of statin-induced myopathy. Methods: An investigational study design was adopted using randomized trials involving patients suffering from ischemic heart disease and receiving either atorvastatin or rosuvastatin. The study was conducted at Punjab Institute of Cardiology, Lahore, Pakistan during the period, November 2016 - February 2017. A total number of 95 male and female patients, between the ages of 40 and 80 years, were

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Demchuk, A. M., D. Tanne, M. D. Hill, et al. "Predictors of good outcome after intravenous tPA for acute ischemic stroke." Neurology 57, no. 3 (2001): 474–80. http://dx.doi.org/10.1212/wnl.57.3.474.

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Background: Thrombolytic therapy for acute ischemic stroke with IV alteplase is increasingly well established in North America but not elsewhere. Baseline factors that altered the response to alteplase were not identified by the National Institute of Neurological Disorders and Stroke tPA Stroke Study Group.Methods: The authors gathered information from centers in the United States, Canada, and Germany on 1,205 patients with acute ischemic stroke treated with IV alteplase. The purpose was to identify independent factors that were predictive of good outcome using multivariable logistic regressio

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