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Journal articles on the topic 'Static and functional occlusion'
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Al-Nimri, Kazem S., Anwar B. Bataineh, and Sawsan Abo-Farha. "Functional Occlusal Patterns and Their Relationship to Static Occlusion." Angle Orthodontist 80, no. 1 (January 2010): 65–71. http://dx.doi.org/10.2319/021209-98.1.
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Oltramari, Paula Vanessa Pedron, Ana Cláudia de Castro Ferreira Conti, Ricardo de Lima Navarro, Márcio Rodrigues de Almeida, Renata Rodrigues de Almeida-Pedrin, and Fernando Pedrin Carvalho Ferreira. "Importance of occlusion aspects in the completion of orthodontic treatment." Brazilian Dental Journal 18, no. 1 (2007): 78–82. http://dx.doi.org/10.1590/s0103-64402007000100017.
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The purpose of this study was to address the therapeutic goals regarding the static and functional occlusion in the completion of orthodontic treatment. For such purpose, a study population comprising 20 female treated Class II malocclusion subjects with an initial mean age of 11 years underwent a two-phase treatment (orthopedics and orthodontics). The patients were diagnosed in centric relation and were treated according to the six keys for normal occlusion and functional occlusal parameters (centric relation, vertical dimension, lateral and anterior guidances, occlusal contacts and direction of forces applied on the teeth). After removal of fixed mechanics, retainers were installed and maintained for two years. Five years after orthodontic completion, the occlusal stability of the patients was evaluated regarding molar relationship and overjet, measured in dental casts. All subjects maintained the normal molar relationship and correct overjet achieved at the end of treatment, indicating a fair level of occlusal stability. The importance of the criteria of the ideal functional occlusion to ensure a better stability after completion orthodontic treatment will be discussed in detail in this paper. In addition, some clinical situations in which localized adjustments are indicated for occlusal refinement will be described.
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Thirumagal K, Revathi Duraisamy, and Ravindra Kumar Jain. "Comparison of group function occlusion and canine guided occlusion among partially edentulous patient – A retrospective study." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (September 10, 2020): 186–91. http://dx.doi.org/10.26452/ijrps.v11ispl3.2911.
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Group function occlusion, as well as Canine guided occlusion, are important in the field of . The study about the occlusion includes not only the static relationship of teeth, but it also includes the functional interrelationship and all the components of the system. The aim of the study is to compare group function occlusion and canine guided occlusion among partially patients. The study was conducted in the outpatient of Dental College and Hospital. The data was reviewed and from the total number of 86000 patients between June 2020. The data includes both group function occlusion and canine guided occlusion patients with a partially condition. Then the data was manually verified by 1-2 reviewers and finally tabulated, and SPSS imported and got the results. 522 Data was included in that males are 55.7% and females are 44% and 0.1% transgender. In that majority of them belong to the age group (31-40) yrs. The group function occlusion is 59.5%, and canine guided occlusion is 40.42%, This shows that Male predominant is seen with group function occlusion. Overall, the results showed that in partially conditions, the canine guided occlusion is more prevalent in male gender when it is compared with group function occlusion.
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Lykhota, K. M. "EVALUATION OF THE DYNAMICS OF OCCLUSION RATIO DURING ORTHODONTIC TREATMENT OF PATIENTS WITH PERMANENT BITE." Ukrainian Dental Almanac, no. 4 (December 12, 2018): 50–54. http://dx.doi.org/10.31718/2409-0255.4.2018.09.
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The unity of the tooth-jaw system is ensured by the close interaction of dental rows, jaws, chewing and facial muscles, temporomandibular joint. Surgical anomalies of bite are often accompanied by significant changes in occlusion ratio of the tooth-jaw system, which significantly affects the quality of life of patients [1, 2, 3]. Significant influence on occlusion ratio has orthodontic treatment. Introduction of high technologies into the practice of prevention and treatment of abnormalities of the zygomatic system contributes to the improvement of dental health, however, the problem of violation of occlusive ratio in dental anomalies and deformations persists in connection with the increase in the prevalence of bite pathology among the population of Ukraine [4, 5].
Investigation of violations of occlusion of dentitions is an integral part of the complex functional analysis of the dental maxillary apparatus. The most common clinical technique for the analysis of occlusive ratio is the technique of occlusion through articulation paper. However, this method does not meet current requirements, because it reflects neither such parameters as the strength and timeliness of tooth contacts, nor contains information about the nature of occlusive violations. Checking only the static parameters of occlusion is not a complete objective method of assessing the quality of treatment. With a sufficient number and correctly placed occlusal contacts, adequate interposition of the components of the temporomandibular joint, the formation of physiological occlusion will be the basis for the uniform distribution of functional loads. In order to solve the problems, a comprehensive study of the parameters of dynamic occlusion is necessary [6, 7].
Up to date, an objective criterion for evaluating occlusion is the use of computerized analysis of occlusion with the help of T-Scan. The results obtained during this study can be used to control the quality of performed orthodontic treatment [6, 7, 8, 9].
Purpose. Determination of the dynamics of occlusal ratio for 117 people of different age groups with sagittal malocclusions during orthodontic treatment generally and specific methods.
Materials and methods of research. Occlusion contacts were assessed using a computerized occlusion analysis of T-Scan III (USA). Depending on the type of pathology of the occlusion, patients were divided into two groups: A (patients with distal occlusion) and B (patients with mesial occlusion), which depended on the method of orthodontic treatment, and were further divided into 2 subgroups.
In the subgroups A1 (33 patients) and B1 (28 patients), the treatment was performed with the help of individual myofunctional apparatus - Elastoelainers, in group II patients of subgroup A2 (35 patients), and patients of subgroup B2 (21 patients) - treatment was carried out using fixed dentistry (bracket system).
The control group consisted of 20 people of the same age with physiological bites and intact dentition.
Results. Studies have shown that people with sagittal malocclusions expressed disturbances of occlusal ratio (presence premature occlusal contacts on the natural teeth, changes in the direction of the trajectory of the total vector occlusion load) experienced significant changes in the dynamics of the proposed orthodontic treatment, and closer to those of the control group immediately after treatment.
Conclusions. The effectiveness of orthodontic treatment of patients with sagittal anomalies of occlusion with the help of individually myofunctional devices has been proved, which is confirmed by the data of the dynamics of indices of computer occlusion.
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Sullivan, T. Y., E. L. DeWeese, P. L. Yu, and G. R. Aronoff. "Lung mechanics and neuromuscular output during CO2 inhalation after airway anesthesia." Journal of Applied Physiology 63, no. 6 (December 1, 1987): 2542–48. http://dx.doi.org/10.1152/jappl.1987.63.6.2542.
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Airway anesthesia with aerosolized lidocaine has been associated with an increase in minute ventilation (VE) during CO2 inhalation. The increase in VE may be due to increased neuromuscular output or decreased mechanical load on breathing. To evaluate this we measured VE, breathing pattern, mouth occlusion pressure, and lung mechanics in 20 normal subjects during room-air breathing and then inhalation of 6% CO2–94% O2, before and after airway anesthesia. Measurements of lung mechanics included whole-lung resistance, dynamic and static compliance, and functional residual capacity. Airway anesthesia had no detectable effect on any measurements during room-air breathing. During CO2 inhalation, airway anesthesia produced increases in VE and mean inspiratory flow rate (VT/TI) and more negative inspiratory pleural pressure but had no detectable effect on lung mechanics or mouth occlusion pressure. Pleural pressure was more negative during the latter 25% of inspiration. We concluded that airway receptors accessible to airway anesthesia play a role in determining neuromuscular output during CO2 inhalation.
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Stick, S., D. Turner, and P. LeSouef. "Transmission of pressure across the chest wall during the rapid thoracic compression technique in infants." Journal of Applied Physiology 76, no. 4 (April 1, 1994): 1411–16. http://dx.doi.org/10.1152/jappl.1994.76.4.1411.
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During the rapid thoracic compression maneuver in infants, the transmission of pressure from compression jacket to pleural space and airway is less at functional residual capacity than at end inspiration. To examine whether reduced pressure transmission at functional residual capacity vs. higher lung volumes is explained by passive characteristics of the chest wall rather than by respiratory muscle activity, we assessed the pressure transmitted across the chest wall in nine anesthetized infants and young children after muscle relaxation. We measured esophageal and airway occlusion pressure during chest compressions at different lung volumes determined by varying distending pressure. In six subjects studied under static conditions, there was an approximately linear relationship between distending pressure and the proportion of pressure transmitted to the airway and esophagus from the compression jacket. The mean r2 value (95% confidence interval) was 0.80 (0.09) for pressure transmission to the airway and 0.85 (0.04) for pressure transmission to the esophagus. This relationship between lung volume and pressure transmission observed under static conditions was also demonstrated dynamically. Thus the reduced transmission of pressure from compression jacket to airway and pleural space at low lung volumes occurs independently of respiratory muscle activity.
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Button, David J., Paul M. Barrett, and Emily J. Rayfield. "Craniodental functional evolution in sauropodomorph dinosaurs." Paleobiology 43, no. 3 (May 22, 2017): 435–62. http://dx.doi.org/10.1017/pab.2017.4.
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AbstractSauropodomorpha included the largest known terrestrial vertebrates and was the first dinosaur clade to achieve a global distribution. This success is associated with their early adoption of herbivory, and sauropod gigantism has been hypothesized to be a specialization for bulk feeding and obligate high-fiber herbivory. Here, we apply a combination of biomechanical character analysis and comparative phylogenetic methods with the aim of quantifying the evolutionary mechanics of the sauropodomorph feeding apparatus. We test for the role of convergence to common feeding function and divergence toward functional optima across sauropodomorph evolution, quantify the rate of evolution for functional characters, and test for coincident evolutionary rate shifts in craniodental functional characters and body mass. Results identify a functional shift toward increased cranial robustness, increased bite force, and the onset of static occlusion at the base of the Sauropoda, consistent with a shift toward bulk feeding. Trends toward similarity in functional characters are observed in Diplodocoidea and Titanosauriformes. However, diplodocids and titanosaurs retain significant craniodental functional differences, and evidence for convergent adoption of a common “adaptive zone” between them is weak. Modeling of craniodental character and body-mass evolution demonstrates that these functional shifts were not correlated with evolutionary rate shifts. Instead, a significant correlation between body mass and characters related to bite force and cranial robustness suggests a correlated-progression evolutionary mode, with positive-feedback loops between body mass and dietary specializations fueling sauropod gigantism.
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GAUCH, Lurdete Maria Rocha, Fabíola SILVEIRA-GOMES, Simone Soares PEDROSA, Renata Antunes ESTEVES, and Silvia Helena MARQUES-DA-SILVA. "Relationship among local and functional factors in the development of denture stomatitis in denture wearers in northern Brazil." Revista de Odontologia da UNESP 43, no. 5 (October 2014): 314–18. http://dx.doi.org/10.1590/rou.2014.050.
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OBJECTIVE: The aim of this study was to evaluate the relationship among functional and qualitative factors in the development of denture stomatitis (DS) (according to Newton's classification) in acrylic-based denture wearers residents from northern Brazil.MATERIAL AND METHOD: A total of 99 patients who wore partial or total acrylic resin-based upper dentures were included in this study. The subjects completed an epidemiological data form that includes the patient's gender, age, local factors (hygiene habits, remove denture to sleep, use of mouthwash, present condition of the denture, age of the denture) and functional factors (vertical dimension at rest, vertical dimension of occlusion, occlusion, retention, and static and dynamic stability). To detect yeasts, samples were collected from the inner surface of the dentures and from the palatal mucosa in contact with it. Subsequently, the samples were cultured on Sabouraud dextrose agar, observing macro and microscopic characteristics.RESULT: In the present study, we did not find any significant relationship between the gender and disease onset. Based on the Newton classification, 36.3% of the patients presented with DS and 89.0% were colonized by yeasts; of these subjects, 50% had type I lesions, 33.3% had type II lesions, and 16.6% had type III lesions. All of the qualitative and local factors, except the use of mouthwash, were clinically relevant to the development of disease.CONCLUSION: Denture stomatitis in denture users in northern Brazil was multifactorial, involving local, functional and microbiological factors.
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Khan, Lubna, Hemant Kumar Halwai, Rajiv Yadav, and Ourvind Jeet Singh Birring. "Orthodontic Camouflage Treatment of Class II Malocclusion in Non-growing Patient - A Case Report." Orthodontic Journal of Nepal 5, no. 1 (February 7, 2015): 46–49. http://dx.doi.org/10.3126/ojn.v5i1.14501.
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The prevalence of skeletal Class II malocclusion is high amongst Asian population. Various treatment modalities have been presented for the treatment of Class II malocclusions in adult patients. We come across many adult patients who desire a costeffective and non-surgical correction and they accept dental camouflage as a treatment option to mask skeletal discrepancy. This case report presents a 26-year-old non-growing female who had a skeletal Class II malocclusion with prognathic maxilla and retrognathic mandible with an overjet of 7 mm, severe crowding, but did not want surgical treatment. We considered the camouflage treatment by extracting upper first premolars. Following the treatment, a satisfactory result was achieved with an acceptable static and functional occlusion, facial profile, smile and lip competence with patient satisfaction.
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Alvarado Sánchez, Jorge Iván, William Fernando Amaya Zúñiga, and Manuel Ignacio Monge García. "Predictors to Intravenous Fluid Responsiveness." Journal of Intensive Care Medicine 33, no. 4 (May 16, 2017): 227–40. http://dx.doi.org/10.1177/0885066617709434.
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Management with intravenous fluids can improve cardiac output in some surgical patients. Management with static preload indicators, such as central venous pressure and pulmonary artery occlusion pressure, has not demonstrated a suitable relationship with changes in the cardiac output induced by intravenous fluid therapy. Dynamic indicators, such as the variability of arterial pulse pressure or stroke volume variation, have demonstrated a suitable relationship. Since improvement in cardiac output does not guarantee an adequate perfusion pressure, in patients with hypotension, it is also necessary to know whether arterial pressure will also increase with intravenous fluid therapy. In this regard, the functional assessment of arterial load by dynamic arterial elastance could help to determine which patients will improve not only their cardiac output but also their mean arterial pressure.
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Pallis, Flavia Rubia, Nicola Conran, Kleber Yotsumoto Fertrin, Sara T. Olalla-Saad, Fernando Ferreira Costa, and Carla Fernanda Franco-Penteado. "Altered Functional Properties of Eosinophils In Sickle Cell Anemia and Effects of Hydroxyurea Therapy." Blood 116, no. 21 (November 19, 2010): 2656. http://dx.doi.org/10.1182/blood.v116.21.2656.2656.
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Abstract Abstract 2656 The pathophysiology of sickle cell anemia (SCA) is now recognized to include a chronic inflammatory condition that contributes to the recurrent episodes of vaso-occlusion that characterize this disease. The vaso-occlusive process is a multi-step process that involves different cell types, such as red blood cells, reticulocytes, activated endothelial cells, platelets and leukocytes. In vivo transgenic animal studies indicated that the neutrophil appears to be the most important leukocyte in vaso-occlusion in previous transgenic animal in vivo studies; however, eosinophils (EOs) may also participate in this phenomenon in humans. EOs are found in significantly elevated numbers in sickle cell disease individuals and, in static adhesion assays, demonstrate augmented adhesive properties suggesting an activated state of these cells. However, the role of EOs in the pathophysiology of SCD and the effect of hydroxyurea (HU) therapy on the functional properties of these cells are not well understood. The aim of this study was to evaluate EO adhesion, migration and degranulation in SCA patients and the effect of HU therapy on these cells. EOs were purified from the peripheral blood of healthy controls (CON) (n≥10), steady-state SCA patients (n≥12) and SCA patients on HU therapy (n≥15), using Percoll gradient separation, followed by immunomagnetic sorting. EO adhesion was determined by static adhesion assays and degranulation was evaluated by measurement of eosinophil peroxidase activity. Migration of EOs was determined in 96-multiwell chemotaxis chamber assays. Plasma levels of Eotaxin-1, 2 and RANTES, important eosinophil attracting chemokines, were determined by ELISA. The absolute number of EOs in the peripheral blood of SCD patients not treated with HU was significantly higher compared to control individuals (0.504±0.09 vs 0.188±0.04; P=0.01, respectively). SCA patients taking HU presented significantly lower numbers of EOs (0.200±0.05, P = 0.01). Basal adhesion of EOs from SCA patients was significantly higher than in healthy controls (22.8±2.6 vs 13.7±1.7%, respectively, P = 0.004). Furthermore, the EOs from SCA patients on HU therapy demonstrated a significantly lower adhesion to fibronectin (12.5±2.0%, P=0.002). Spontaneous EO chemotaxis was significantly increased in SCA patients, compared to healthy controls (12.9±1.56 vs 6.97±0.8 × 105/ml, respectively, P=0.009). Interestingly, the chemotatic response of EOs isolated from SCA patients taking HU was also higher than that of control EOs (12.1± 1.9 × 105/ml). EO chemotaxis in response to RANTES, Eotaxin and IL5 was significantly augmented in all groups compared to spontaneous chemotaxis (RANTES: CON: 15.3± 2.3; SCA: 19.9±3.0; SCAHU: 25.0±4.7; Eotaxin: CON: 18.7±3.0; SCA: 24.5±4.2; SCAHU: 24.0±5.2; IL5: CON: 13.4±2.4; SCA: 18.8±3.0, SCAHU: 16.6±4.5, P<0.05). Baseline eosinophil peroxidase release was higher in SCA EOs, compared to CON EOs (0.4±0.04 vs 0.2±0.02, respectively, P=0.001), but patients on HU presented a lower EOs degranulation than SCA not on HU (0.19±0.03, P=0.003). Plasma levels of Eotaxin-1 and RANTES were significantly higher in SCA individuals, compared to CON individuals (124±7; 1057±125 vs 78±7; 540±50.2 pg/ml, P=0.0002; P=0.0009, respectively). HU therapy was not associated with any change in Eotaxin-1 and RANTES plasma levels (117.9±9.7; 1175±126.2 pg/ml, respectively). Eotaxin-2 plasma levels did not vary among groups (485±80.8, 450±34, 398±47.8 pg/ml for CON, SCA and SCAHU, respectively). EOs of patients with SCA demonstrate a higher capacity for spontaneous migration, stimulated migration and degranulation. Therapy with HU is associated with reduced adhesion and degranulation of EOs in these patients, but had no effect on the chemotactic ability of these cells or chemokine levels. The presence of relative eosinophilia along with altered functional properties in SCA patients warrants further investigation of the role of EOs in the vaso-occlusive process. In particular, complications associated with allergic reactions, such as acute thoracic syndrome and asthma in SCA children, in which EO adhesion and degranulation may be more important, should be studied. The characteristics of the effect of HU on EO also suggest that SCA events in which EO chemotaxis plays a role are likely to respond poorly to HU therapy, and should lead to the development of alternative therapeutic strategies. Disclosures: No relevant conflicts of interest to declare.
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Vovk, V. V., and V. P. Nespriadko. "EVALUATION OF CEPHALOMETRIC ANALYSIS IN PATIENTS WITH BILATERAL CONDYLAR RETROPOSITION IN TEMPOROMANDIBULAR DYSFUNCTION." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 3 (November 12, 2020): 41–46. http://dx.doi.org/10.31718/2077-1096.20.3.41.
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Relevance. During the dentoalveolar growth and development, the direction and growth type of facial skull play a very important role. Development of esthetical symmetry, functional relationship, and clinical disharmony depends on skull parameters. Temporomandibular joint dysfunction is one of the most common diseases nowadays. That is why early identification of risk factors is among the priorities. This study aimed at evaluating occlusional and skeletal specific characteristics in patients with temporomandibular joint dysfunction, comparing different cephalometric findings and CT findings relating to condylar position. Materials and methods. The study included 45 individuals. The study group consisted of 26 patients with bilateral condylar retroposition. Control group was made up of 19 patients. The participants underwent clinical examination, functional testing, palpation of masticatory muscles, occlusion diagnosis by applying Baush articulating film 200,100,8 microns, cephalometric analysis: Tweed, Kim, Jarabak, Ricketts, computed tomography of temporomandibular joint. Statistical analysis was carried out by the program IBM SPSS Statistic Base v.22. Results. There were no pathological contacts during evaluation of static and dynamic occlusion, laterotrusion as «canine guidance». The patients of the test group had bilateral posterior joint fissure reduced right-median 1,96, left-median 1,81. In control group the position was right-average 2,75 and left-median 2,67 The patients in the control and test groups the indices Tweed <FMA average were 19,6°/ median 21,7°; <IMPA average 97,9°/ median 97,8°; Kim ODI median was 68,9°/73,74°; Ricketts Overbite median 2.1 mm /1,9 mm, Overjet median was 2,9 mm /2,85 mm, PM-Xi-ANS median was 44,1°/43,75°, <NPog-FH median was 91°/86,85°,<NBa-PtGn median was 91,1°/90,1°, <MeGo-FH median was 18,7°/22,4°; Jarabak <N-S-Ar average was 127,2°/125,6 °. Conclusions. In the patients with bilateral condylar retropositionm the joint fissure is reduced. Cephalometric analysis demonstrated the following: Tweed <FMA, <IMPA; Kim ODI; Ricketts Overbite, Overjet, PM-Xi-ANS, <MeGo-FH; Jarabak <N-S-Ar can not be used as diagnostic criteria of bilateral condylar retroposition. Ricketts <NPog-FH in the test group showed the mandibular retroposition, but with normal type of mandibular growth <NBa-PtGn. It can be used as one of the primary cephalometric diagnostic indicator of bilateral condylar retroposition.
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Sultana, Naznin, Md Nazmul Hasan, Gazi Shamim Hassan, Mir Abu Naim, and Nasrin Akther. "Orthodontic camouflage management of a class II malocclusion with excessive overjet- A case report." Update Dental College Journal 3, no. 1 (February 17, 2014): 41–45. http://dx.doi.org/10.3329/updcj.v3i1.17984.
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In orthodontic practice various treatment modalities have been presented for the treatment for the class II, div 1malocclusions. Recently a large number of young adults have been seeking shorter, cost effective and a non surgical correction of Class II malocclusions and they accept dental camouflage as a treatment option to mask the skeletal discrepancy .This case report presents one such case, a 15years old growing male who has Class II div I malocclusion with sever maxillary incisor proclination, convex profile ,high mandibular plane angle, incompetent lips, increased overjet& overbite, over retained upper left deciduous canine ,impacted upper left canine and a supernumerary tooth in canine region. We considered the camouflage treatment by extracting the upper right first premolar, left impacted canine, deciduous canine and supernumerary tooth. Following the treatment, a satisfactory result was achieved with an ideal, static and a functional occlusion, facial profile, acceptable smile, competent lip and stable treatment results. DOI: http://dx.doi.org/10.3329/updcj.v3i1.17984 Update Dent. Coll. j: 2013; 3 (1): 41-45
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Pinheiro Júnior, Jesus Maués, Amanda Cruz Rocha, Thayna Silva Do Carmo Tavares, Carlos Alberto Gonçalves Júnior, and Thais Bueñano França Penin. "Tratamento em duas fases do padrão II com má oclusão de Classe II, divisão 1 por protrusão maxilar." Orthodontic Science and Practice 14, no. 54 (2021): 49–61. http://dx.doi.org/10.24077/2021;1454-4961.
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Objective: to carry out a literature review on the treatment of Pattern II for maxillary protrusion and Class II division 1 malocclusion, its different possibilities of approach and to present a case report in two phases. Methods: The BIREME, Google Academic and Pubmed databases were used to obtain articles in English and Portuguese. As search strategy, we have used the terms boolean AND, AND NOT and OR to order the keywords and delimit the object of study. Results: It was found in the literature that two-phase treatment can be performed with the maxillary splint device in the mixed dentition to approach the maxillary protrusion. Then, in the period of young permanent denture, the appliance is self-ligating as a device for refining static and functional occlusion. Conclusion: The approach to Class II malocclusion in Pattern II by maxillary protrusion can be performed in two phases, a fact corroborated by the success of the treatment performed and by the literature evaluated in this study.
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Zhu, Jiaying, Mengmeng Ma, Jinghuan Fang, Jiajia Bao, Shuju Dong, Ning Chen, Yijia Guo, and Li He. "Prestroke statin use enhances collateralization in acute ischemic stroke patients." Restorative Neurology and Neuroscience 38, no. 4 (September 24, 2020): 311–21. http://dx.doi.org/10.3233/rnn-201012.
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Background: Statin therapy has been shown to be effective in the prevention of ischemic stroke. In addition, recent studies have suggested that prior statin therapy could lower the initial stroke severity and improve stroke functional outcomes in the event of stroke. It was speculated that prestroke statin use may enhance collateral circulation and result in favorable functional outcomes. Objective: The aim of the study was to investigate the association of prestroke statin use with leptomeningeal collaterals and to determine the association of prestroke statin use with stroke severity and functional outcome in acute ischemic stroke patients. Methods: We prospectively and consecutively enrolled 239 acute ischemic stroke patients with acute infarction due to occlusion of the middle cerebral artery within 24 h in the neurology department of West China Hospital from May 2011 to April 2017. Computed tomographic angiography (CTA) imaging was performed for all patients to detect middle cerebral artery thrombus; regional leptomeningeal collateral score (rLMCS) was used to assess the degree of collateral circulation; the National Institutes of Health Stroke Scale (NIHSS) was used to measure stroke severity at admission; the modified Rankin scale (mRS) was used to measure outcome at 90 days; and premorbid medications were recorded. Univariate and multivariate analyses were performed. Results: Overall, 239 patients met the inclusion criteria. Fifty-four patients used statins, and 185 did not use statins before stroke onset. Prestroke statin use was independently associated with good collateral circulation (rLMCS > 10) (odds ratio [OR], 4.786; 95% confidence interval [CI], 1.195–19.171; P = 0.027). Prestroke statin use was not independently associated with lower stroke severity (NIHSS score≤14) (OR, 1.955; 95% CI, 0.657–5.816; p = 0.228), but prestroke statin use was independently associated with favorable outcome (mRS score≤2) (OR, 3.868; 95% CI, 1.325–11.289; P = 0.013). Conclusions: Our findings suggest that prestroke statin use was associated with good leptomeningeal collaterals and clinical outcomes in acute ischemic stroke (AIS) patients presenting with occlusion of the middle cerebral artery. However, clinical studies should be conducted to verify this claim.
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Sander, Mikael, Vaughan G. Macefield, and Luke A. Henderson. "Cortical and brain stem changes in neural activity during static handgrip and postexercise ischemia in humans." Journal of Applied Physiology 108, no. 6 (June 2010): 1691–700. http://dx.doi.org/10.1152/japplphysiol.91539.2008.
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Static isometric exercise increases muscle sympathetic nerve activity (MSNA) and mean arterial pressure, both of which can be maintained at the conclusion of the exercise by occlusion of the arterial supply [postexercise ischemia (PEI)]. To identify the cortical and subcortical sites involved, and to differentiate between central command and reflex inputs, we used blood oxygen level-dependent (BOLD) functional MRI (fMRI) of the whole brain (3 T). Subjects performed submaximal static handgrip exercise for 2 min followed by 6 min of PEI; MSNA was recorded on a separate day. During the contraction phase, parallel increases in BOLD signal intensity occurred in the contralateral primary motor cortex and cerebellar nuclei and cortex; these matched the effort profile and ceased at the conclusion of the contraction. Progressive increases in the contralateral insula and primary and secondary somatosensory cortices, with progressive decreases in the perigenual anterior cingulate and midcingulate cortices, were sustained during the period of PEI and thus did not depend on central command. Discrete bilateral activation of the medial and lateral dorsal medulla was also observed during the contraction and PEI; we believe that these represent the nucleus tracts solitarius (NTS) and rostral ventrolateral medulla (RVLM), respectively. Given that metaboreceptor afferents are known to project to the NTS and that the RVLM is the primary output nucleus for MSNA, our data support that the metaboreflex is mediated by the medulla, whereas the somatosensory, insular, and anterior cingulate cortices are involved in the sensory and affective components of the maneuver.
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Silin, A. V., E. A. Satygo, M. G. Semenov, E. I. Semeleva, N. A. Kondrateva, and M. B. Trushko. "Functional status of maxillofacial area in children with asymmetric congenital abnormalities and acquired maxillofacial deformities." Kazan medical journal 93, no. 5 (October 15, 2012): 760–63. http://dx.doi.org/10.17816/kmj1705.
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Aim. To determine the masticatory muscles functional activity change in children with congenital abnormalities of maxillofacial area and acquired maxillofacial deformities at the stages of reconstructive plastic surgery. Methods. 10 children at the age from 10 to 14 years with acquired (1st group - 5 patients with secondary temporomandibular joint osteoarthritis, asymmetric micrognathia) and unilateral congenital maxillofacial deformities (2nd group - 5 patients with I-II branchial arches syndrome, asymmetric micrognathia) were examined. Occlusion parameters and electromyographic features of masticatory muscles were analyzed. Results. Occlusal contact estimation did not reveal any significant differences between the groups. The symmetry of masticatory muscles at teeth clenching was higher in children with acquired asymmetric micrognathia (the index of asymmetry at electromyography 1.95±2.1%) compared to children with congenital asymmetric micrognathia (the index of asymmetry at electromyography 23.06±18.8%), p=0.005. Total activation index of masticatory muscles at electromyography ranged from 143 to 64% in patients with temporomandibular joint osteoarthritis and from 127 to 75% in children with I-II branchial arches syndrome. None of the patients included in the study had any complaints of temporomandibular joint and masticatory muscles condition. This was confirmed by no difference in muscular balance static index in two groups. Nevertheless, in patients with I-II branchial arches syndrome a much more sufficient asymmetry was observed. Orthodontic treatment and reconstructive surgery did not succeed in asymmetry index restoration to normal ranges. Conclusion. In children with symmetric abnormalities and acquired deformities functional status of maxillofacial area can be rapidly restored after reconstructive treatment at well-planned orthodontic rehabilitation; maxillofacial area functional status in patients with unilateral abnormalities can not be fully restored, since muscle asymmetry persists for a long time.
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Dzalaeva, Fatima K., S. O. Chikunov, A. S. Utyuzh, Z. K. Dzhagaeva, and A. V. Yumashev. "Application of the complex algorithm for rehabilitation of patients needing a full reconstruction of dentition (clinical case)." Russian Journal of Dentistry 24, no. 3 (October 3, 2020): 158–63. http://dx.doi.org/10.17816/1728-2802-2020-24-3-158-163.
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Introduction. Aim of the study is testing the algorithm of complex clinical, functional and instrumental analysis in the treatment of patients with the need for total restoration of the dentition with manifestations of myofascial pain syndrome.
Material and methods. A system for the rehabilitation of patients with adentia is proposed, in which, when planning occlusion correction, objective examination data for patients obtained using a set of diagnostic methods should be taken into account. Particular attention is paid to assessing the function of the temporomandibular joint and the presence of pathological signs of disorders of maxillofacial muscles.
Results. A clinical case is described a patient who has been diagnosed with a set of indicators of clinical, functional and instrumental analysis obtained using methods of condylography and cephalometry. The results of treatment and rehabilitation measures allowed achieving the optimal distribution of loads on the dentition, while reducing the risk of ceramic chipping and improving oral hygiene. The approach used allowed timely correction of functional and aesthetic disorders.
Conclusions. The algorithm for working with patients who need total restoration of the dentition should include a thorough history taking, clinical functional analysis using condylography methods, model analysis to register and evaluate the static and dynamic ratios of the dentition. As well as performing cephalometric analysis and other manipulations, in accordance with standard criteria for clinical examination. The developed algorithm is anatomically and pathogenetically justified, since it takes into account the entirety of changes and interconnections of the structures of the dentofacial system and other body systems that underlie the clinical manifestations in this category of patients.
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Markstrom, Agneta M., Michael Lichtwarck-Aschoff, Bjorn A. Svensson, K. Anders Nordgren, and Ulf H. Sjostrand. "Ventilation with Constant Versus Decelerating Inspiratory Flow in Experimentally Induced Acute Respiratory Failure." Anesthesiology 84, no. 4 (April 1, 1996): 882–89. http://dx.doi.org/10.1097/00000542-199604000-00016.
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Background Recognition of the potential for ventilator-associated lung injury has renewed the debate on the importance of the inspiratory flow pattern. The aim of this study was to determine whether a ventilatory pattern with decelerating inspiratory flow, with the major part of the tidal volume delivered early, would increase functional residual capacity at unchanged (or even reduced) inspiratory airway pressures and improve gas exchange at different positive end-expiratory pressure levels. Methods Surfactant depletion was induced by repeated bronchoalveolar lavage in 13 anesthetized piglets. Decelerating and constant inspiratory flow ventilation was applied at positive end-expiratory pressure levels of 22, 17, 13, 9, and 4 cm H(2)O. Tidal volume, inspiration-to-expiration ratio, and ventilatory frequency were kept constant. Airway pressures, gas exchange, functional residual capacity (using a wash-in/washout method with sulfurhexafluoride), central hemodynamics, and extravascular lung water (using the thermo-dye-indicator dilution technique) were measured. Results Decelerating inspiratory flow yielded a lower arterial carbon dioxide tension compared to constant flow, that is, it improved alveolar ventilation. There were no differences between the flow patterns regarding end-inspiratory occlusion airway pressure, end-inspiratory lung volume, static compliance, or arterial oxygen tension. No differences were seen in hemodynamics and oxygen delivery. Conclusions The decelerating inspiratory flow pattern increased carbon dioxide elimination, without any reduction of inspiratory airway pressure or apparent improvement in arterial oxygen tension. It remains to be established whether these differences are sufficiently pronounced to justify therapeutic consideration.
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VITTURI, Bruno Kusznir, and Rubens José GAGLIARDI. "Effects of statin therapy on outcomes of ischemic stroke: a real-world experience in Brazil." Arquivos de Neuro-Psiquiatria 78, no. 8 (August 2020): 461–67. http://dx.doi.org/10.1590/0004-282x20200027.
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ABSTRACT Background: Statin therapy has become one of the most important advances in stroke secondary prevention. Objective: To provide evidence from real-world data for evaluating detailed associations between secondary prevention of stroke and statin use in Brazil. Methods: We conducted a prospective cohort study including consecutive patients diagnosed with an ischemic stroke. Subjects were classified into non-statin, simvastatin 20 mg, simvastatin 40 mg, and high-potency statin groups. We also registered the onset of statin therapy, previous use of statins, the adherence to medication, and if there was discontinuation of the therapy. After two years, the functional outcome, stroke recurrence, major cardiovascular events, and mortality were assessed. Results: Among the 513 patients included in our cohort, there were 96 (18.7%) patients without statins, 169 (32.9%) with simvastatin 20 mg, 202 (39.3%) with simvastatin 40 mg, and 46 (9.0%) with high-potency statins. Patients without statins were at increased risk of stroke recurrence and worse functional outcomes. Concerning etiology, evidence of beneficial use of statins was observed in cases of large-artery atherosclerosis, small-vessel occlusion, and stroke of undetermined cause. Those who presented poor adherence to statins or discontinuation of the treatment had worse prognosis after stroke whereas the early onset of statins use was associated with better outcomes. Patients with simvastatin 40 mg and high-potency statins presented the best functional recovery throughout the follow-up. Conclusions: Statins play an important role in the treatment of ischemic stroke, preventing stroke recurrence and cardiovascular events, and improving functional performance.
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Rogozhnikov, Aleksey. "OPTIMIZATION OF ORTHOPEDIC TREATMENT OF PATIENTS WITH DEFECTS OF HARD TISSUES OF DENTS AND DENTAL SERIES USING DIGITAL FUNCTIONAL METHODS." Actual problems in dentistry 16, no. 2 (August 12, 2020): 121–28. http://dx.doi.org/10.18481/2077-7566-20-16-2-121-128.
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Subject. The current level of development of dentistry requires the use of an algorithm for diagnosis, monitoring and quality control of orthopedic treatment of patients using functional research methods, planning and manufacturing of dental prosthesis designs based on digital technologies.
The goal is to develop an algorithm for orthopedic treatment of patients with defects in the hard tissues of teeth and dentitions using digital functional examination methods.
Methodology. Clinical data are based on the results of orthopedic treatment of two groups of patients with defects in the hard tissues of teeth and dentitions. The main group consisted of 129 people, whose diagnostic and treatment complex had an extended instrumental clinical and functional analysis of static and dynamic ratios of teeth and jaws, and orthopedic treatment was carried out according to an improved CAD/CAM protocol. Comparison group ― 147 people, comprehensive dental diagnostics and prosthetic treatment carried out using the standard CAD/CAM technique.
Results. Using in-depth functional diagnostics of the dento-jaw system based on digital technologies, a comprehensive assessment of the status of the dental status of the examined patients is given, an algorithm for their comprehensive diagnosis and treatment is developed, indications for their prosthetics in the usual occlusion or in the central ratio of the jaws are specified. The production of fixed anatomical structures of dentures has been optimized by improving the methodology for modeling their masticatory surfaces using the Hint-Els CAD/CAM system.
Conclusions. Analysis of the examination results and monitoring of the stages of orthopedic treatment of patients testifies to the effectiveness of the proposed algorithm and advanced CAD/CAM technology. The developed indications for the replacement of defects in the hard tissues of teeth and dentitions are determined as the result of many years of research that can achieve practical results ― increasing the effectiveness of their treatment using digital functional diagnostic methods and orthopedic treatment.
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Bradley, J. D., P. B. Zanaboni, and T. E. Dahms. "Species differences in pulmonary vasoactive responses to histamine, 5-hydroxytryptamine, and KCl." Journal of Applied Physiology 74, no. 1 (January 1, 1993): 139–46. http://dx.doi.org/10.1152/jappl.1993.74.1.139.
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Species differences in the longitudinal distribution of pulmonary vascular resistance (PVR) in response to 5-hydroxytryptamine (5-HT) or histamine (His) may be attributed to variations in the distribution of functional smooth muscle between arteries and veins estimated by the response to KCl. Isolated dog, guinea pig, or rabbit lungs were perfused at a constant flow = 55–75 ml.min-1.kg body wt-1. Pulmonary arterial (Ppa); arterial, double, and venous occlusion (Po,a; Pdo; Po,v, respectively); and pulmonary venous (Ppv) pressures were measured before and after increasing PVR by infusing His, 5-HT, or KCl. 5-HT and His increased Ppa--Pdo in rabbits but Pdo--Ppv in guinea pigs. In dogs, 5-HT increased Ppa--Po,a, but His increased Pdo--Ppv. Dynamic (Co,v) and static vascular compliance (CP-Q), as well as critical closing pressure (Pcc, the gamma-intercept of pressure-flow curves), were also measured. At baseline, Co,v was the same among species. However, CP-Q was higher than Co,v in all lungs and was significantly different among species in order of (in ml.cmH2O-1.100 g-1) rabbit (4.54 +/- 0.28) > guinea pig (3.31 +/- 0.18) > dog (2.21 +/- 0.13). Increases in Pcc correlated with increases in microvascular resistance (Po,a--Po,v) but not with increases in PVR after agonist infusion. KCl responses suggest that guinea pigs and rabbits have relatively more functional smooth muscle in venous and arterial microvessels, respectively, whereas dogs have approximately equal amounts.(ABSTRACT TRUNCATED AT 250 WORDS)
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Gersh, Kathryn C., Sergei Zaitsev, Douglas B. Cines, Vladimir Muzykantov, and John W. Weisel. "Flow-dependent channel formation in clots by an erythrocyte-bound fibrinolytic agent." Blood 117, no. 18 (May 5, 2011): 4964–67. http://dx.doi.org/10.1182/blood-2010-10-310409.
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Abstract Studies in animal models have shown that plasminogen activators bound to erythrocytes (RBC-PA) have an extended lifetime in the circulation and are safer than free PAs. RBC-PAs incorporate into nascent thrombi, which are focally lysed from within, an attractive thromboprophylactic option. In static systems, RBC-PAs cleave surrounding fibrin fibers, forming pores larger than the cells themselves, and move around the pore edges, enlarging them until eventual clot dissolution. We hypothesized that under flow in blood vessels, RBC-PAs form functional patent channels before clot dissolution. Here we used perfusion chambers to study clot lysis by RBC-PAs under static versus arterial and venous flow conditions. We found that flow decelerates bulk clot lysis but quickly generates patent channels filled with passing RBCs, via pore enlargement and merging in the direction of flow. Formation of such channels by RBC-PAs may help rescue ischemic tissue before bulk dissolution of potentially occlusive clots.
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Gribov, Denis, Mikhail Antonik, Denis Butkov, Alexandr Stepanov, Pavel Antonik, Yaser Kharakh, Anton Pivovarov, and Sergey Arutyunov. "Personalized Biomechanical Analysis of the Mandible Teeth Behavior in the Treatment of Masticatory Muscles Parafunction." Journal of Functional Biomaterials 12, no. 2 (April 9, 2021): 23. http://dx.doi.org/10.3390/jfb12020023.
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A 3D finite element model of the mandible dentition was developed, including 14 teeth, a periodontal ligament (PDL), and a splint made of polymethylmethacrylate (PMMA). The study considered three design options: 1—the case of splint absence; 2—the case of the splint presence installed after manufacture; and 3—the case of splint presence installed after correction (grinding) performed to ensure a uniform distribution of occlusal force between the teeth. For cases of absence and presence of splint, three measurements of the functional load were performed using the T-Scan III software and hardware complex (TekScan, Boston, MA, USA). It was found that the presence of a splint led to a decrease in the total value of the occlusive load and to a uniform distribution between all the mandible teeth. The occlusal force was considered as a static vertical force evenly distributed between the nodes belonging to the occlusive surface of the corresponding tooth for the first design option and the occlusal surface of the splint for the second and third ones, respectively. As a result of the study, it was concluded that the splint usage was effective in order to change the distribution of the functional load during the treatment of proved masticatory muscles’ parafunction; the safety of using a splint for teeth and surrounding tissues under the influence of the considered functional load was shown; the potential applicability of PMMA as a structural material of a splint that had been used for the treatment of masticatory muscles’ parafunction was established.
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Pelosi, P., M. Croci, I. Ravagnan, M. Cerisara, P. Vicardi, A. Lissoni, and L. Gattinoni. "Respiratory system mechanics in sedated, paralyzed, morbidly obese patients." Journal of Applied Physiology 82, no. 3 (March 1, 1997): 811–18. http://dx.doi.org/10.1152/jappl.1997.82.3.811.
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Pelosi, P., M. Croci, I. Ravagnan, M. Cerisara, P. Vicardi, A. Lissoni, and L. Gattinoni. Respiratory system mechanics in sedated, paralyzed, morbidly obese patients J. Appl. Physiol. 82(3): 811–818, 1997.—The effects of inspiratory flow and inflation volume on the mechanical properties of the respiratory system in eight sedated and paralyzed postoperative morbidly obese patients (aged 37.6 ± 11.8 yr who had never smoked and had normal preoperative seated spirometry) were investigated by using the technique of rapid airway occlusion during constant-flow inflation. With the patients in the supine position, we measured the interrupter resistance (Rint,rs), which in humans probably reflects airway resistance, the “additional” resistance (ΔRrs) due to viscoelastic pressure dissipation and time-constant inequalities, and static respiratory elastance (Est,rs). Intra-abdominal pressure (IAP) was measured by using a bladder catheter, and functional residual capacity was measured by the helium-dilution technique. The results were compared with a previous study on 16 normal anesthetized paralyzed humans. Compared with normal persons, we found that in obese subjects: 1) functional residual capacity was markedly lower (0.645 ± 0.208 liter) and IAP was higher (24 ± 2.2 cmH2O); 2) alveolar-arterial oxygenation gradient was increased (178 ± 59 mmHg); 3) the volume-pressure curve of the respiratory system was curvilinear with an “inflection” point; 4) Est,rs, Rint,rs, and ΔRrs were higher than normal (29.3 ± 5.04 cmH2O/l, 5.9 ± 2.4 cmH2O ⋅ l−1 ⋅ s, and 6.4 ± 1.6 cmH2O ⋅ l−1 ⋅ s, respectively); 5) Rint,rs increased with increasing inspiratory flow, Est,rs did not change, and ΔRrs decreased progressively; and 6) with increasing inflation volume, Rint,rs and Est,rs decreased, whereas ΔRrs rose progressively. Overall, our data suggest that obese subjects during sedation and paralysis are characterized by hypoxemia and marked alterations of the mechanical properties of the respiratory system, largely explained by a reduction in lung volume due to the excessive unopposed IAP.
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Shida, Yasuaki, Christine Brown, Jeff Mewburn, Kate Sponagle, Ozge Danisment, Barbara Vidal, Carol A. Heagadorn, and David Lillicrap. "Comprehensive In Vitro and In Vivo Characterization of Loss and Gain-of-Function Von Willebrand Factor Collagen Binding Variants Using a Mouse Model System,." Blood 118, no. 21 (November 18, 2011): 3266. http://dx.doi.org/10.1182/blood.v118.21.3266.3266.
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Abstract Abstract 3266 Von Willebrand Factor (VWF) is a large multimeric glycoprotein that mediates platelet adhesion to the damaged blood vessel wall and subsequent platelet aggregation at the site of injury. Rare mutations in the VWF A3 domain, that disrupt collagen binding, have been found in patients with a mild bleeding phenotype. However, the analysis of these aberrant VWF-collagen interactions has been relatively limited. Thus, in this study, we have developed mouse models of collagen binding mutants and analyzed the function of the A3 and A1 domains using comprehensive in vitro and in vivo approaches. All of the collagen binding variant AAs are conserved in mice. 6 loss-of-function (S1731T, W1745C, S1783A, H1786D, A1 deletion, A3 deletion) and 1 gain-of-function (L1757A) variant was generated in the context of the mouse VWF cDNA. The 4 loss-of-function missense mutants have all been described in patients with mild bleeding phenotypes. The recombinant mouse VWFs (rmVWF) were synthesized in HEK293T cells and analyzed for type I and III collagen binding in both a static assay (CBA) and a flow-based assay at 2,500s−1 in which VWF is bound to collagen on a surface, and labeled platelet adhesion is quantified. The multimer profile of all the rmVWFs was normal. The expression level of the rmVWF derived from HEK293T cells was quantified. W1745C and the A3 deletion showed significantly lower levels of expression and the A1 deletion mutant showed strong intracellular retention. In the static collagen binding assay, S1731T showed almost normal binding to collagen type I and a 50% reduction in binding to collagen type III. The other 3 missense variants, W1745C, S1783A and H1786D, showed reduced binding to both collagens I and III, and the A3 deletion mutant showed absent binding. In the in vitro flow assay, the sensitivity to detect defects in collagen binding was superior to the static assay, although the patterns of binding defects were similar. W1745C showed similar low levels of platelet adhesion to both types of collagen, while S1783A and H1786D showed a lack of platelet binding on the collagen III surface similar to the A3 deletion mutant, and a reduced binding to collagen type I similar to W1745C. The gain-of-function mutant showed consistent enhanced collagen binding and platelet adhesion in the static and flow assays, respectively. In vivo studies delivered the mVWF cDNAs with a strong liver specific promoter by hydrodynamic injection. At 7 days post-delivery, the VWF:Ag levels in the WT and collagen binding variant mice were similar, apart from the W1745C mutant, that showed 14.6% levels compared to WT. Platelet counts and multimer patterns were normal with the collagen binding variants. In vivo intravital microscopy studies were performed using the cremaster arteriolar model when VWF levels were in a physiological range. Thrombosis was induced by 10%FeCl3 applied for 3 mins. Platelets were labeled in vivo by Rhodamine 6G and the thrombus development was analyzed by spinning disc confocal microscopy. Loss-of-function mutants showed transient platelet adhesion at the site of injury, however the adhesion was unstable and vessel occlusion was not observed. Using three complementary experimental systems we have been able to confirm the collagen binding defects in this group of variant VWFs. There is a differential sensitivity to the two forms of collagen and of the three experimental systems. The A3 deletion mutant consistently resulted in the most severe phenotype while the missense mutants showed variable degrees of functional deficit. Disclosures: No relevant conflicts of interest to declare.
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Batra, Puneet, Ritu Duggal, and Hari Parkash. "Functional Occlusion in Orthodontics." Journal of Indian Orthodontic Society 39, no. 2 (June 2005): 80–90. http://dx.doi.org/10.1177/0974909820050203.
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Stebbins, C. L., and J. C. Longhurst. "Potentiation of the exercise pressor reflex by muscle ischemia." Journal of Applied Physiology 66, no. 3 (March 1, 1989): 1046–53. http://dx.doi.org/10.1152/jappl.1989.66.3.1046.
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The reflex responses to static contraction are augmented by ischemia. The metabolic “error signals” that are responsible for these observed responses are unknown. Therefore this study was designed to test the hypothesis that static contraction-induced pressor responses, which are enhanced during muscle ischemia, are the result of alterations in muscle oxygenation, acid-base balance, and K+. Thus, in 36 cats, the pressor response, active muscle blood flow, and muscle venous pH, PCO2, PO2, lactate, and K+ were compared during light and intense static contractions with and without arterial occlusion. During light contraction (15–16% of maximal), active muscle blood flow increased without and decreased with arterial occlusion (+35 +/- 12 vs. -60 +/- 11%). Arterial occlusion augmented these pressor responses by 132 +/- 25%. Without arterial occlusion, changes (P less than 0.05) were seen in PO2, O2 content, PCO2, and K+. Lactate and pH were unchanged. With arterial occlusion, changes in muscle PCO2 were augmented and significant changes were seen in pH and lactate. During intense static contraction (67–69% of maximal), muscle blood flow decreased without arterial occlusion (-39 +/- 9%) and decreased further during occlusion (-81 +/- 6%). Arterial occlusion augmented the pressor responses by 39 +/- 12%. All metabolic variables increased during contraction without arterial occlusion, but occlusion failed to augment any of these changes. These data suggest that light static ischemic contractions cause increases in muscle PCO2 and lactate and decreases in pH that may signal compensatory reflex-induced changes in arterial blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
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Reddy, K. Praveen Kumar, G. Vivek Reddy, and Nellore Chaitanya. "Functional occlusion and temperomandibular joint." Annals and Essences of Dentistry 6, no. 2 (2014): 51. http://dx.doi.org/10.5958/0976-156x.2014.00025.2.
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Karad, Ashok, and Shruti Chhajed. "Cephalometric analysis for functional occlusion." APOS Trends in Orthodontics 6 (November 25, 2016): 287–94. http://dx.doi.org/10.4103/2321-1407.194793.
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Background Various elements contributing to good functional occlusion have not been clearly assessed with cephalometrics for the diagnosis of functional problems and their application in clinical practice. The aim of this study, therefore, was to analyze different components of functional occlusion to formulate concise functional cephalometric analysis. Materials and Methods Eighty-two cases (38 males and 44 females), with class I occlusion and balanced facial profile, were examined based on the selection criteria, and cephalograms were taken in natural head position. All the radiographs were then analyzed using various functional parameters. Results The mean values of condylar path angle and incisal path angle were 55.83° and 65.67°, respectively, with large deviations. However, both showed positive correlation. The value of the angle of long axis of mandibular incisor with respect to the line joining center of condyle and lower incisor tip was 88.04°. Moreover, the angle between the occlusal plane and horizontal plane was 12.88°. In vertical plane, lower face height (LFH) was found to be slightly less than the upper face height. Maxilla contributed around 45% of the LFH while mandible formed about 60%. Furthermore, upper alveolar component (maxillary alveolar height) formed more than half of the maxilla (53.79%) whereas lower alveolar component (mandibular alveolar height) was 74.8% of the mandible. Conclusion This study has analyzed various components of functional occlusion and formulated a concise functional cephalometric analysis for diagnosis, treatment planning, and assessment of treatment results.
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Clark, J. R., and R. D. Evans. "Functional Occlusion: I. A Review." Journal of Orthodontics 28, no. 1 (March 2001): 76–81. http://dx.doi.org/10.1093/ortho/28.1.76.
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Jenkins, W. G. "Wax-up for functional occlusion." Journal of Dentistry 19, no. 5 (October 1991): 323. http://dx.doi.org/10.1016/0300-5712(91)90089-h.
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Graber, T. M. "An introduction to functional occlusion." American Journal of Orthodontics 87, no. 1 (January 1985): 83. http://dx.doi.org/10.1016/0002-9416(85)90179-4.
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Chai, Xiao Li, Yan Zhang, and Jin Si. "Research on Video Segmentation Based on Static Background." Applied Mechanics and Materials 644-650 (September 2014): 1947–49. http://dx.doi.org/10.4028/www.scientific.net/amm.644-650.1947.
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Video segmentation algorithm based on background reconstruction, and the statistical method of cumulation obtain to complete occlusion of background information domain by, using video object in the current frame and the background image subtraction, successfully overcome the occlusion problem,and in a static background, more accurate segmentation results can be obtained for the moving target.
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Al-Nassar, Doaa B., and Hadeel A. Al-Hashimi. "Orthodontic Considerations of Functional Occlusion in Class І Normal Occlusion." Journal of Baghdad College of Dentistry 27, no. 3 (2015): 130–39. http://dx.doi.org/10.12816/0015047.
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Lingojwar, Devendra, Savita Bhutoria, Fantao Meng, Sangeetha Thangaswamy, Henny H. Billett, Caterina Minniti, Amy Tsai, Marcos Intaglietta, Craig A. Branch, and Seetharama A. Acharya. "Therapeutic Activity of Peg Albumin in Transgenic Mouse Model of Sickle Cell Disease Is a Function of the Pattern of Pegylation." Blood 128, no. 22 (December 2, 2016): 4848. http://dx.doi.org/10.1182/blood.v128.22.4848.4848.
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Abstract Background Conjugation of Albumin (Alb) with six copies of PEG 5K chains using extension arm chemistry (EAF) generates a novel semisynthetic supra perfusion resuscitation fluid (EAF P5K6 Alb) that performs better than the conventional colloidal plasma expanders in extreme hemodilution and hemorrhagic shock animal models. The superior activity of EAF P5K6 Alb is attributed to its property of increasing functional capillary density. This product has been shown to increase the efficacy of blood transfusion when given in combination with blood. The influence of pattern of surface decoration on SCD therapeutic activity of PEG Alb with one copy of PEG 30K (P30K1Alb) and six copies of PEG5K (EAF P5K6 Alb) has been investigated in the chronic mouse model of SCD, BERK low ϒ. Two important questions posed here are: 1) Does the pattern of PEGylation influence the increase in hydrodynamic volume and packing density of PEG shell in the PEG30KAlb adducts and 2) Does the P30K1Alb and EAF P5K6 Alb have the similar SCD therapeutic activity. Methods P30K1 Alb was prepared by PEGylation at Cys34 of Alb using maleimidopropionamido PEG30K followed by ion exchange chromatography purification. EAF P5K6 Alb was purified by tangential flow filtration method. Intravital microscopy analysis for the assessment of therapeutic effects of both the PEG Alb adducts was examined in the cremaster muscle of transgenic SCD mice. Berk low ϒ mice were infused with 10 % top load of a 4 gm % PEG Alb solutions (either EAF P5K6 Alb or P30K1 Alb) by IP and the attenuation of vaso-occlusion, as well as improvement in blood flow has been compared. Results P30K1 Alb elutes as a very resolved material in ion exchange column and its 1 copy of PEG30K was confirmed by NMR studies. The hydrodynamic volume of P30K1 Alb is higher than EAF P5K6 Alb as reflected by size exclusion chromatography, even though the overall total mass to the Alb is same. This reflects that P30K1 is more flexible than EAF P5K6 Alb. The molecular radius and COP of EAFP5K6Alb is higher whereas viscosity is less than that of P30K1Alb (Table 1). Accordingly, plasma expander like properties of PEG Alb when surface decorated with a given total mass of PEG is a function of pattern of PEGylation. EAF P5K6 Alb exhibited a significant therapeutic activity after 3 hours (hrs) of treatment, as seen by the attenuation of the vaso-occlusion (Fig 1). This effect remained the same after 24 hrs. There was no noticeable change in the blood flow or RBC velocity in spite of significant reduction in leukocyte adhesion. Discussions and Conclusions The correlation of pattern of PEGylation of PEG Alb with the supra perfusion activity of EAF P5K6 Alb has been investigated by Tsai et. al. (unpublished results) by designing EAF P3K10. It was concluded that EAF P5K6 is the better pattern of PEGylation to induce the supra perfusion. Results suggest that the PEGylation induced increase in the hydrodynamic volume under flow is higher with a single copy of PEG30K than 6 copies of PEG 5K. Under flow conditions, PEG 30K and P30K1Alb exhibit comparable hydrodynamic volume, conjugating Alb to PEG 30K has not much influence on the overall hydrodynamic volume of PEGAlb. On the other hand, under static conditions, the packing density of its PEG shell is lower than that of EAF P5K6 Alb. There is significant reduction in adhesion of leucocytes in 3 hrs of treatment with EAF P5K6 Alb as seen in the intravital microscopy studies. However very little effect is seen in terms of changes in the blood flow. After 24 hrs of treatment, there is increase in emigration of leukocytes. Surprisingly, P30K1 has little or no SCD therapeutic activity. The amount of PEG Alb used here is only small (10 %) as compared to about 25 % in hemorrhagic shock models; accordingly, the contribution of viscosity is small, if any. We suggest that the SCD therapeutic activity of EAF P5K6 Alb is primarily related to the "parachute effect" of PEG Alb with multiple copies of PEG chains. We have also shown that EAF hexaPEGylation of Tempol (antioxidant) conjugated Alb, synergistically increased the antioxidant therapeutic activity Alb Tempol in attenuating the experimentally induced vaso-occlusive crisis in a transgenic mouse model of SCD, NY1DD. The P30K1 Alb lacks such a parachute-like effect. These results raise the important question whether the "mushroom" structure of EAF P3K10 Alb may show more SCD therapeutic activity than EAF P5K6 Alb and EAF P3K10 Alb conjugated with antioxidant. Disclosures No relevant conflicts of interest to declare.
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Lindstrom, Gary. "Static evaluation of functional programs." ACM SIGPLAN Notices 21, no. 7 (July 1986): 196–206. http://dx.doi.org/10.1145/13310.13331.
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van den Berg, KG, and PM van den Broek. "Static analysis of functional programs." Information and Software Technology 37, no. 4 (January 1995): 213–24. http://dx.doi.org/10.1016/0950-5849(95)90813-a.
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Sabitov, V. Kh, N. F. Salimova, N. B. Salimov, and Z. M. Galeev. "Occlusion clamps with improved functional characteristics." Biomedical Engineering 27, no. 5 (September 1993): 243–44. http://dx.doi.org/10.1007/bf00557217.
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King, Gregory. "Settling of the Occlusion Following Orthodontic Treatment may not Improve Functional Occlusion." Journal of Evidence Based Dental Practice 10, no. 2 (June 2010): 99–100. http://dx.doi.org/10.1016/j.jebdp.2010.02.004.
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Deroze, Danielle, and Jean Lacout. "Occlusal finishing, functional occlusion, and elastodontic concept." Journal of Dentofacial Anomalies and Orthodontics 14, no. 2 (June 2011): 208. http://dx.doi.org/10.1051/odfen/2011207.
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Morris, James B. "Functional Occlusion: From TMJ to Smile Design." Journal of Prosthodontics 17, no. 3 (April 2008): 251. http://dx.doi.org/10.1111/j.1532-849x.2008.00313.x.
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Li, Yushi, George Baciu, Yu Han, and Chenhui Li. "Improved SfM-Based Indoor Localization with Occlusion Removal." International Journal of Software Science and Computational Intelligence 10, no. 3 (July 2018): 24–40. http://dx.doi.org/10.4018/ijssci.2018070102.
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This article describes a novel 3D image-based indoor localization system integrated with an improved SfM (structure from motion) approach and an obstacle removal component. In contrast with existing state-of-the-art localization techniques focusing on static outdoor or indoor environments, the adverse effects, generated by moving obstacles in busy indoor spaces, are considered in this work. In particular, the problem of occlusion removal is converted into a separation problem of moving foreground and static background. A low-rank and sparse matrix decomposition approach is used to solve this problem efficiently. Moreover, a SfM with RT (re-triangulation) is adopted in order to handle the drifting problem of incremental SfM method in indoor scene reconstruction. To evaluate the performance of the system, three data sets and the corresponding query sets are established to simulate different states of the indoor environment. Quantitative experimental results demonstrate that both query registration rate and localization accuracy increase significantly after integrating the authors' improvements.
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KIM, YOUNG EUN, SUNG YOON CHO, and HYUNG YUN CHOI. "ANALYSIS OF DURAL-SAC OCCLUSION IN A LUMBAR SPINAL MOTION SEGMENT FE MODEL." Journal of Musculoskeletal Research 05, no. 04 (December 2001): 243–52. http://dx.doi.org/10.1142/s0218957701000647.
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Occlusion of dural-sac in the lumbar spine was quantitatively analyzed by utilizing one motion segment of finite element lumbar spine model developed in this study. And the mechanism of occlusion, considering both static and viscous behavior of materials, was also investigated with various loading conditions. Occlusion was quantified by calculating the cross sectional area change or volumetric changes of dural-sac. In the static analysis, it was found that less than 2 kN of compressive load could not produce dural-sac occlusion but the compression together with extension moment was more likely to produce the dural-sac occlusion. The 7.4% of occlusion was obtained when the 8 Nm of extension moment was added to 2 kN of compressive load which alone did not create any occlusion. The magnitude of occlusions was increased to 10.5% as the extension moment become to 10 Nm with the same 2 kN of compressive load. In creep analysis, 10 Nm extension, kept for 3600 seconds, induced 6.9% of occlusion and 2.4% of volume reduction in dural-sac. However, flexion moment did not produce any occlusion in dural-sac but increased the volume instead because it caused stretching of dural-sac coupled with vertebra motion. As a conclusion, occlusions resulted mainly from the slackening of ligamentum flavum and disc bulging, and the amount of occlusion was strongly dependent with loading condition and visco-elastic behavior of materials as well.
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Stanescu, Ioana, Angelo Bulboaca, Dana Fodor, and Gabriela Dogaru. "Functional outcome after symtomatic internal carotid artery occlusion." Balneo Research Journal 10, no. 10.2 (May 20, 2019): 134–38. http://dx.doi.org/10.12680/balneo.2019.252.
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Abstract Internal carotid artery occlusion accounts for 15-20% of ischemic strokes, caused by atherosclerosis or dissection. Clinical symptoms are variable, from asymptomatic cases to minor or severe strokes. Diagnosis in internal carotid artery (ICA) occlusion is based on imaging techniques. Prognosis after ICA occlusion depends on many factors: severity of neurologic deficit, spontaneous recanalization of the artery, and the occurrence of recurrent strokes. Patients with spontaneous recanalization of the occluded ICA tend to have a retained functional ability and favorable clinical outcomes. Medical treatment, recanalization techniques and intensive rehabilitation program are essential in improving functional outcome of patients with stroke produced by ICA occlusion. We present the case of a young patient diagnosed with ischemic stroke produced by internal carotid artery occlusion, with consecutive severe neurologic deficit, and an unfavorable functional outcome, as evaluated with the Modified Rankin Scale. Spontaneous recanalization of the occluded ICA was observed after 6 weeks, suggesting a carotid dissection. The patient was included in an intensive rehabilitation program, associated with best medical therapy, showing improvement of its functional status at 3 months follow up. Key words: ischemic stroke, carotid artery occlusion, carotid dissection, spontaneous recanalization, functional outcome,
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KUSAKARI, Keiichirou. "Static Dependency Pair Method in Functional Programs." IEICE Transactions on Information and Systems E101.D, no. 6 (June 1, 2018): 1491–502. http://dx.doi.org/10.1587/transinf.2017fop0004.
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Fuentealba, P., and Y. Simón-Manso. "Static Dipole Polarizabilities through Density Functional Methods." Journal of Physical Chemistry A 101, no. 23 (June 1997): 4231–35. http://dx.doi.org/10.1021/jp963903g.
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Maziasz, R. L., and J. P. Hayes. "Layout optimization of static CMOS functional cells." IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 9, no. 7 (July 1990): 708–19. http://dx.doi.org/10.1109/43.55210.
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Navarro, Gonzalo, and Kunihiko Sadakane. "Fully Functional Static and Dynamic Succinct Trees." ACM Transactions on Algorithms 10, no. 3 (June 2014): 1–39. http://dx.doi.org/10.1145/2601073.
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Chirilă, Oana Cristina, Alexandru Eugen Petre, and Mihaela Rodica Păuna. "The role of virtual articulators in dental occlusion analysis." Romanian Journal of Stomatology 63, no. 1 (March 31, 2017): 28–32. http://dx.doi.org/10.37897/rjs.2017.1.5.
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Today, virtual reality has a broad spectrum of applications in fields as diverse as architecture, sports, arts or medicine. One of the applications of virtual reality in medicine is the virtual articulator, a digital instrument that was designed as a tool for comprehensive analysis of static and dynamic occlusal relations, the purpose being to substitute the use of mechanical articulators and consequently, of the mechanical errors involved by their use. This paper is a systematic review of the literature on published studies about the functionality and application of the virtual articulators in the analysis of dental occlusion. An electronic search was conducted based on a combination of keywords, using the search engines of Pubmed/Medline and ScienceDirect. Most of the identified studies show that the reproduction of occlusal contacts using virtual articulators has superior, or at least similar, fidelity compared to the conventional techniques, both in static or dynamic manners.