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1

Fok, Elsie. "Advanced stem cell delivery systems for the treatment of corneal epithelial limbal stem cell deficiency." Thesis, University of Brighton, 2014. https://research.brighton.ac.uk/en/studentTheses/134e3b10-9910-40d6-bec8-8a7481b9e67e.

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Limbal stem cell deficiency (LSCD) can be treated successfully using ex vivo limbal epithelial stem cells (LESC) derived from cadaveric donor tissue. However, shortages in such tissues and graft rejection, resulting from inflammation, are persistent issues. The purpose of this study was to optimize current culturing techniques used for LESC transplant tissue, considering expansion and cryopreservation issues surrounding the establishment of a stem cell bank. In addition, a novel anti-inflammatory biomimetic peptide was investigated to address issues surrounding amnion and steroid use in LESC t
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2

Barennise, Arries. "Knowledge, perceptions and practices of members of the health care team involved in stem cell transplantations in the Western Cape." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2880.

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Thesis (MTech (Nursing))--Cape Peninsula University of Technology, 2017.<br>Stem cell transplantation has become one of the standard methods of treatment for patients with malignant and benign blood disorders. The multidisciplinary team interacting with these patients and their families, must be knowledgeable concerning the appropriate quality health care. The objectives of the study were to explore the knowledge of the members of the health care team in terms of the processes that need to be adhered to with stem cells transplantation, as well as exploring the perceptions amongst the health ca
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3

Lau, Ka-kit George, and 廖家傑. "Hepatitis B infection and hematopoietic stem cell transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31981756.

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4

Shanmugam, Shiva Prasad. "COMMERCIALIZATION OF STEM CELL THERAPY FOR THE TREATMENT OF DIABETIC RETINOPATHY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1278691262.

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5

Leslie, Shirae. "An Injectable Stem Cell Delivery System for Treatment of Musculoskeletal Defects." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4472.

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The goal of this research was to develop a system of injectable hydrogels to deliver stem cells to musculoskeletal defects, thereby allowing cells to remain at the treatment site and secrete soluble factors that will facilitate tissue regeneration. First, production parameters for encapsulating cells in microbeads were determined. This involved investigating the effects of osmolytes on alginate microbead properties, and the effects of alginate microbead cell density, alginate microbead density, and effects of osteogenic media on microencapsulated cells. Although cells remained viable in the mi
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6

Barthelmes, Daniel. "A stem cell based approach for vascular repair in diabetic retinopathy." Phd thesis, Sydney Medical School, 2012. http://hdl.handle.net/2123/14171.

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7

Gotlieb, Eric. "Research to develop stem cell and tissue engineering therapies for endodontic treatment." Thesis, NSUWorks, 2007. https://nsuworks.nova.edu/hpd_cdm_stuetd/11.

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8

Tate, Matthew C. "The development of extracellular matrix based neural stem cell transplants for treatment of traumatic brain injury." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/20166.

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9

Baylis, Oliver Jack. "The safety and efficacy of ex vivo expanded autologous limbal stem cells for the treatment of unilateral total limbal stem cell deficiency." Thesis, University of Newcastle upon Tyne, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748549.

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The cornea is the clear window at the front of the eye, which allows light to focus onto the retina. The outer surface is covered in epithelial cells that are continually replaced by a population of stem cells located at the edge of the cornea termed the limbal stem cells. Limbal stem cell deficiency (LSCD) results in epithelial failure and conjunctival overgrowth, resulting in a painful, blinding disease. This condition can be treated by the transplantation of ex vivo expanded limbal stem cells from a donor eye in a technique originally described by Pellegrini et al. in 1997. Previously, a pr
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10

Hägglund, Hans. "Risk-factors, prevention and treatment of early complications after allogeneic haematopoietic stem cell transplantation /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3034-1/.

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11

Latham, Nicholas. "Second Generation Cardiac Cell Therapy: Combining Cardiac Stem Cells and Circulating Angiogenic Cells for the Treatment of Ischemic Heart Disease." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24293.

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Blood-derived circulatory angiogenic cells (CACs) and resident cardiac stem cells (CSCs) have both been shown to improve cardiac function after myocardial infarction (MI) but the superiority of either cell type has long been an area of speculation with no definitive head-to-head trial. In this study, we compared the paracrine profile of human CACs and CSCs, alone or in combination. We characterized the therapeutic ability of these cells to salvage myocardial function in an immunodeficient mouse model of MI by transplanting these cells as both single and dual cell therapies seven days after e
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12

Morse, Zachary J. "Dose Response Analysis of Bone Marrow-Derived Mesenchymal Stem Cells for Treatment in Fascial Wound Repair." Youngstown State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1444052561.

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13

Lui, R. "IN VIVO IMAGING OF STEM CELL MEDIATED TREATMENT IN A MOUSE MODEL OF SPINAL CORD INJURY." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150208.

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Introduction: The use of adult stem cells in cell-mediated therapies is an area of considerable interest within tissue regeneration research. However, important variables such as the distribution of the injected cells, cell survival, target organ localisation cell proliferation and differentiation cannot be evaluated in vivo by using classical imaging approaches. This study propose multiple labelling protocols for in vivo visualisation by MRI, nuclear imaging and BLI of adult murine neural stem cell-mediated therapy, in spinal cord injury animal models. Methods: Murine neural stem cells (mNSCs
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14

Stok, Kathryn. "Biological quantification of murine osteoarticular joints following treatment using stem cell-based gene therapy /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17400.

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15

Chen, Aiqing. "Treatment of periventricular white matter injury in a rodent model by stem cell transplantation." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506595.

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16

Lamsfus, Calle Andrés [Verfasser]. "Hematopoietic stem cell gene therapy for the treatment of β-hemoglobinopathies / Andrés Lamsfus Calle". Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1224232410/34.

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17

Zhang, Liyi, and 張麗儀. "Identification and characterization of tumor suppressor gene and cancer stemness gene in esophageal squamous cell carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/208563.

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Esophageal squamous cell carcinoma (ESCC), the major histological subtype of esophageal cancer, is one of the most common malignancies with poor prognosis in the world. Despite continued development of diagnosis and treatment, ESCC remains the sixth leading cause of cancer death worldwide. Current treatment regimens in ESCC are often characterized by ineffectiveness and poor selectivity. Therapeutic methods directed at cancer-associated genes or cancer stem cells (CSCs) may be effective approaches to cure this deadly cancer. Therefore, this study aims to identify specific ESCC-related genes an
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18

袁敏婷 and Minting Yuan. "A collagen microencapsulation : assisted stem cell-based approach for treating degenerative disc disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/193390.

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Degenerative disc disease (DDD) is a medical condition whereby the intervertebral discs (IVD) of the human spine degenerates and may cause pain which significantly affects the quality of one掇 life. Its prevalence has sparked off much research in deciphering its causes and developing new treatments. Recently, attempts to treat this degenerative problem have turned to seeking answers from regenerative medicine. One approach is to deliver mesenchymal stem cells (MSCs) with or without carriers to the nucleus pulposus (NP) in degenerative disc to restore both its structural and functional propertie
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19

Farouz, Yohan. "Designing biomaterials for controlled cardiac stem cell differentiation and enhanced cell therapy in the treatment of congestive heart failure." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB114/document.

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La thérapie cellulaire se positionne comme une stratégie prometteuse pour inciter le cœur infarci à se régénérer. A cet effet, des études récentes placent des espoirs considérables dans l’utilisation des cellules souches embryonnaires et notre laboratoire a déjà démontré comment les différencier en progéniteurs cardiovasculaires, un type de précurseurs cellulaires qui ne peut aboutir qu’à la formation de cardiomyocytes, de cellules endothéliales ou de cellules de muscles lisses. Cet engagement précoce réduit leur capacité de prolifération anarchique et en même temps leur permet de rester suffi
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20

O'Brien, Ciara. "Breast cancer initiating cells in tamoxifen treatment and resistance." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/breast-cancer-initiating-cells-in-tamoxifen-treatment-and-resistance(074d121d-d39b-413d-ae0c-ae54ae1c0293).html.

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Resistance to endocrine treatments in oestrogen receptor positive (ER+) breast cancer (BC) significantly contribute to patient morbidity and mortality. ER+ BC constitute 60% of all breast cancers although there is considerable clinico-pathological diversity within this group. Breast cancer initiating cells (BCICs) are implicated in tumour relapse and metastasis and are postulated to drive resistance to standard anti-cancer therapies. However little is known about the sensitivity of BCICs to endocrine therapies. We assessed the effect of tamoxifen treatment and acquired tamoxifen resistance on
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21

Leung, Ka-kit Gilberto, and 梁嘉傑. "Applications of self-assembling peptide nanofibre scaffold and mesenchymal stem cell graft in surgery-induced brain injury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206347.

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Surgery-induced brain injury (SBI) refers to trauma caused by routine neurosurgical procedures that may result in post-operative complications and neurological deficits. Unlike accidental trauma, SBI is potentially subject to preemptive interventions at the time of surgery. SBI can cause bleeding, inflammation and the formation of tissue gaps. Conventional haemostatic techniques, though effective, are not necessarily conducive to healing. Inflammation and the absence of extracellular matrix in tissue gaps also hinder regeneration after SBI. This study investigated the applications of RADA16-I,
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22

Leslie, Shirae. "The controlled release of rat adipose-derived stem cells from alginate microbeads for bone regeneration." Thesis, Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/48946.

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Cell-based therapies have potential for tissue regeneration but poor delivery methods lead to low viability or dispersal of cells from target sites, limiting clinical utility. Here, we developed a degradable and injectable hydrogel to deliver stem cells for bone regeneration. Alginate microbeads <200µm are injectable, persist at implantation sites and contain viable cells, but do not readily degrade in-vivo. We hypothesized that controlled release of rat adipose-derived stem cells (ASCs) from alginate microbeads can be achieved by incorporating alginate-lyase in the hydrogel. Microbeads were f
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23

Larsson, Kajsa. "Cytomegalovirus after allogeneic haematopoietic stem cell transplantation : complications in the era of CMV-specific antiviral treatment /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-735-5/.

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24

Herasymenko, O. S., V. I. Smolanka, A. V. Smolanka, and S. Sechko. "Intraoperative neurophysiological monitoring at stem-cell tumors surgical treatment: prognostic value for patients' further physiotherapeutic rehabilitation." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/63560.

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Investigation of the intraoperative neurophysiological monitoring effectiveness (motor and somatosensory induced potentials, spontaneous and trigger electroneuromyography) in surgical treatment of patients with stem-cell tumors<br>Badanie skuteczności monitorowania śródoperacyjnego neurofizjologicznego (potencjały indukowane silnymi i somatosensorowymi, spontaniczna i wyzwalająca elektroneuromiografia) w chirurgicznym leczeniu pacjentów z guzami komórek macierzystych.
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25

Sandoval, Maria Luisa. "EVALUATING THE ROLE OF BREAST CANCER STEM CELL POPULATIONS AS PREDICTORS OF RESPONSE TO TRASTUZUMAB TREATMENT." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1405093548.

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26

Evans, Corey. "THE EFFECTS OF SDF-1α TREATMENT ON THE MIGRATION OF NEURAL STEM/PROGENITOR CELLS AFTER TRAUMATIC BRAIN INJURY". VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2486.

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Traumatic Brain Injury (TBI) is one of the leading causes of death and disability among young adults and has been a significant field in medical research over the past decades. Intensive studies focusing on how to repair tissue damage resulting from head injuries have discovered that the central nervous system (CNS) retains a regenerative capacity throughout life due to the persistent presence of neural stem/progenitor cells (NS/NPCs) in the neurogenic regions. In the normal brain, cells generated in the subventricular zone (SVZ) migrate along the rostral migratory stream (RMS) to the olfactor
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27

Poppe, Daniel [Verfasser]. "Gene targeting in human pluripotent cell-derived neural stem cells for the study and treatment of neurological disorders / Daniel Poppe." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1080561188/34.

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28

Miri, Ammar. "Corneal epithelial stem cell deficiency : in vivo and in vitro analysis of diagnostic features and treatment outcomes." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601801.

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Several clinical and laboratory studies suggest that the niche for corneal epithelial stem cells is located in the corneoscleral limbus. Of particular interest are the palisades of Vogt (POV), which are a series of fibrovascular palisade like structures found predominantly along the superior and inferior limbus. The study was designed to use a relatively new and powerful tool, the laser in vivo confocal microscopy (Rostock corneal module confocal microscope) of scanning laser ophthalmoscope, ) HRTII; to evaluate in details normal anatomical features of the limbus and establish diagnostic featu
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29

Villani, Valentina. "Evaluation of the therapeutic potential of amniotic fluid stem cells for the treatment of a model of type I diabetes." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422489.

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Type I diabetes (T1D), also known as diabetes mellitus or juvenile diabetes, is a metabolic disorder characterized by the selective destruction of pancreatic β cells of the islets of Langerhans. This loss, caused by an autoimmune attack of the endocrine cells, leads to hypoinsulinemia and hyperglycemia. T1D has nowadays reached epidemic proportions and the number of patients is rapidly increasing. To date, treatments are limited to administration of exogenous insulin and islets transplantation therapy, whose widespread applicability is though limited by scarcity of donors and risks related to
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30

Campbell, Niall Gordon Simon. "An investigation of initial retention of stem/progenitor cells following intracoronary injection : implications to cell therapy for the treatment of heart failure." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8659.

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Intracoronary injection is a frequently used clinical protocol for stem/progenitor cell therapy to the heart. Initial donor cell retention in the heart is the key to the success of this approach; however, this process has been poorly investigated. I established an original model to quantitatively assess initial donor cell retention after intracoronary cell injection in rats using an ex-vivo heart perfusion system and investigated factors that could affect retention. The initial retention efficiency of bone marrow mononuclear cells (BMMNC) was 20% after injection into normal hearts. The majorit
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31

Welch, Sarah Ann. "Prognostic factors for patients with diffuse large B cell lymphoma and transformed indolent lymphoma undergoing autologous stem cell transplantation in the positron emission tomography era." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21274.

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Thesis (M.A.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>High dose chemotherapy followed by autologous stem cell transplantation (ASCT) remains the standard of care for patients with relapsed or refractory (R/R) diffuse large B cell lymphoma (DLBCL) who are chemosensitive to salvage ther
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Zhang, Qi [Verfasser]. "Immunohistochemical Study of Spinal Cord Injury Induced Neuropathic Pain with GABAergic Neural Stem Cell Transplantation Treatment / Qi Zhang." Tübingen : Universitätsbibliothek Tübingen, 2021. http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1190103.

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33

Olsson-Strömberg, Ulla. "Clinical and Experimental Studies in Chronic Myeloid Leukemia : Studies of Treatment Outcome, In Vitro Cellular Drug Resistance and Gene Expression." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7841.

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<p>The aims of the studies described in the thesis were to investigate different treatment strategies in chronic myeloid leukemia (CML) patients. Furthermore, activity of imatinib was investigated by <i>in vitro</i> cytotoxicity assay, and the gene expression pattern in interferon treated patients.</p><p>In a randomized prospective national study, we examined the influence of busulphan (n=89) versus hydroxyurea (n=90) treatment on time to blast crisis, and survival. There was no significant difference in survival between hydroxyurea and busulphan treated patients; median survival was 3.5 and 3
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34

Li, Hua, and 李華. "Cell and gene therapies for diabetes: exploration of novel therapeutic approaches." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38430800.

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35

Xu, Jinfeng [Verfasser]. "Investigation of ALDH bright cancer stem (-like) cell-targeted treatment by Cisplatin and all-trans retinoic acid in cervical cancer cell lines / Jinfeng Xu." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1223453146/34.

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36

Hallböök, Helene. "Acute lymphoblastic leukaemia in adult patients : studies of prognostic factors, treatment results and in vitro cellular drug resistance /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5768.

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37

Gerfen, Ashlee, and Myke Green. "Chemomobilization with Cyclophosphamide and Filgrastim in Multiple Myeloma Patients Following Lenalidomide Treatment." The University of Arizona, 2012. http://hdl.handle.net/10150/614472.

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Class of 2012 Abstract<br>Specific Aims: Autologous stem cell transplant (ASCT) is the current gold standard following induction therapy to improve survival of multiple myeloma (MM). Lenalidomide (LEN) is used for treatment of MM before ASCT, but exposure may impair autologous peripheral blood stem cell (PBSC) mobilization. Chemomobilization with cyclophosphamide (CTX) has not been evaluated in this setting. CTX + filgrastim was investigated to determine if LEN-associated mobilization impairment can be abrogated. Methods: 36 pts (group A=12 pts who received ≥2 cycles of LEN and group B=24 p
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McGill, Gemma. "Caregivers' experiences and coping strategies relating to patient's subjective treatment-related cognitive impairment following Haematopoietic Stem Cell Transplant (HSCT)." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7660/.

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The treatments involved in cancers of the blood and bone marrow can be physically and psychologically challenging and be associated with adverse secondary effects, including cognitive impairment. The incidence and severity of treatment-related cognitive impairment varies widely, however it can significantly impact quality of life by interfering with patients’ activities of daily living, relationships and future plans. It can also pose challenges for the patients’ caregivers, an area which has received comparatively less research attention. The aim of this study was to investigate caregivers’ e
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Çakmak, Görür Neşe [Verfasser]. "Targeting the hematopoietic stem cell antigen FLT3 by high-affinity T cell receptor for the treatment of high-risk acute myeloid leukemia / Neşe Çakmak Görür." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1226154557/34.

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Carroll, Dustin W. "TARGETING THE CELLULAR REDOX ENVIRONMENT: A NOVEL APPROACH FOR THE TREATMENT OF HEMATOPOIETIC NEOPLASMS." UKnowledge, 2018. https://uknowledge.uky.edu/toxicology_etds/21.

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Hematopoietic stem cells (HSCs) that function to maintain the hematopoietic compartment through self-renewal and differentiation capacities, as well as their downstream progeny, are susceptible to transformation resulting in the generation of the leukemic stem cell (LSC). Chief in the factors that control HSC regulation and protection of the HSC compartment is the cellular redox environment. Deregulation of the Hematopoietic Stem/Progenitor Cell (HSPC) redox environment results in loss of HSPC function and exhaustion. The characteristic developments of HSPC exhaustion via exposure to redox str
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LANZILLOTTI, CARMEN. "Innovative drug delivery scaffolds as novel therapeutic strategy for bone tissue regeneration and treatment of osteosarcoma." Doctoral thesis, Università degli studi di Ferrara, 2022. http://hdl.handle.net/11392/2482878.

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Nuovi biomateriali impiantabili con sistema di rilascio di farmaci anti-tumorali stanno emergendo come terapia alternativa per la riparazione del tessuto osseo e il trattamento del cancro osseo, compreso l'osteosarcoma (OS). Biomateriali composti da idrossiapatite nanostrutturata, con stronzio (CD-HA2%Sr) funzionalizzati con i farmaci metotrexato (CD-HA2%Sr-MTX) e doxorubicina (CD-HA2%Sr-DOX), potrebbero rappresentare una nuova strategia terapeutica per la rigenerazione ossea e il trattamento dell’OS. L’OS è una neoplasia maligna dell’osso che colpisce pazienti pediatrici. Nonostante gli svan
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Tse, Hung-fat, and 謝鴻發. "Bone marrow cell transplantation for therapeutic angiogenesis in ischemic myocardium: from bench to bedside." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557972.

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Farrag, Mahmoud. "Tissue engineering and pharmacological approaches for the treatment of spinal cord injuries." University of Akron / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=akron1578705731120767.

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Bielecki, Peter. "Advanced Mesoporous Silica Nanoparticles for the Treatment of Brain Tumors." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case159558503832021.

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DePaul, Marc A. "INTRAVENOUS MULTIPOTENT ADULT PROGENITOR CELL TREATMENT DECREASES INFLAMMATION LEADING TO FUNCTIONAL RECOVERY FOLLOWINGSPINAL CORD INJURY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1451317702.

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46

Hänel, Mathias, Friedrich Fiedler, and Christoph Thorns. "Anti-CD20 Monoclonal Antibody (Rituximab) and Cidofovir as Successful Treatment of an EBV-Associated Lymphoma with CNS Involvement." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135105.

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Background: Epstein-Barr virus(EBV)-associated posttransplant lymphoproliferative disease (PTLD) is a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). Especially in cases with involvement of the central nervous system (CNS) treatment is difficult because the efficacy of most chemotherapeutic agents as well as EBV-specific cytotoxic donor T cells in liquor is uncertain. In the last years the anti-CD20 monoclonal antibody Rituximab was intensively investigated in the treatment of EBV-PTLD. However, only 8 patients with B-cell lymphoma and CNS involvement trea
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47

Talegaonkar, Sonia S. "The Role of Human MSC Derived Exosomes in the Treatment of Periodontal Diseases." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4969.

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Periodontal disease affects 47% of Americans over 30. Characterized by microbial dysbiosis and unregulated inflammation, severe periodontitis causes degradation of bone and soft tissue around teeth. Current treatments have limited regenerative outcomes and frequent reinfection by harmful bacteria. Human mesenchymal stem cells (hMSCs) have been shown to promote wound healing and tissue regeneration. Many therapeutic benefits of hMSCs are due to their secretome products, like exosomes. Our long-term goal is to develop periodontal therapies with hMSC exosomes. The objectives of this study were to
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48

Hayes, Sandra C. "Exercise, functional capacity and quality of life in peripheral blood stem cell transplant patients." Thesis, Queensland University of Technology, 2001. https://eprints.qut.edu.au/36758/7/36758_Digitised%20Thesis.pdf.

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49

Leishman, Alison Jane. "Harnessing the immunomodulatory capacity of dendritic cells differentiated from human induced pluripotent stem cells and the therapeutic potential of dendritic cell-derived exosomes for the treatment of lysosomal storage diseases." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:97f6791f-ff69-4645-9a3d-2ff23ce69529.

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Lysosomal storage diseases (LSDs) are a collection of disorders that feature the pathological accumulation of substrate frequently due to an enzymatic defect within the lysosomes. The most effective treatment regime for LSDs is enzyme replacement therapy. However, this treatment has faced two main challenges which have limited its treatment efficacy and clinical impact. One challenge constitutes the potential immunogenicity of the replaced enzyme, which can lead to the induction of an antibody response that prevents its effective targeting. Therefore, this thesis investigated the potential to
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Leishman, Alison Jane. "Harnessing the immonomodulatory capacity of dendritic cells differentiated from human induced pluripotent stem cells and the therapeutic potential of dendritic cell-derived exosomes for the treatment of lysosomal storage diseases." Thesis, University of Oxford, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711748.

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