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Dissertations / Theses on the topic 'Stem cells – Research'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 January 2023

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1

Marshall, Gregory Paul. "Neurospheres and multipotent astrocytic stem cells neural progenitor cells rather than neural stem cells /." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010047.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 97 pages. Includes Vita. Includes bibliographical references.

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2

Elichabe, Benoît. "United States stem cells research boundaries." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39529.

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Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management, 2007.<br>Includes bibliographical references (leaves [88]-90).<br>Recent empirical work has demonstrated the importance of a number of elements of scientific infrastructure that seem to be crucial particularly in fields such as molecular and cellular biology in which the materiality of research renders the process of replication and validation more complex. Scientific infrastructure has many interconnecting elements such as the ability to exchange material used in experiments, the ability to share ideas and inf

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3

Nortjé, Nico. "The moral status of embryonic stem cell research in the South African context /." Link to the online version, 2007. http://hdl.handle.net/10019.1/1372.

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4

Chen, Shi. "Cryopreservation of human embryonic stem cells and hepatocytes." Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711665.

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5

Ngangan, Alyssa V. "Bioactive factors secreted by differentiating embryonic stem cells." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44913.

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Current therapeutic strategies to stimulate endogenous angiogenic processes within injured tissue areas are typically based on introducing exogenous pro-angiogenic molecules or cell populations. Stem cell transplantation for angiogenic therapy aims to deliver populations of cells that secrete angiogenic factors and/or engraft in the new branching vasculature within the damaged tissue. Utilizing stem or progenitor cells has been shown to induce a rather robust angiogenic response despite minimal repopulation of the host vasculature, suggesting that stem cells may provide paracrine factors tha

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6

Ericson, Robin J. "Bridging solutions to the religion and science conflict over human embryonic stem cell research." Fairfax, VA : George Mason University, 2007. http://hdl.handle.net/1920/2926.

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Thesis (Ph. D.)--George Mason University, 2007.<br>Title from PDF t.p. (viewed Jan. 17, 2008). Thesis director: Richard E. Rubenstein. Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Conflict Analysis and Resolution. Vita: p. 228. Includes bibliographical references (p. 222-227). Also available in print.

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7

Alawadhi, Aseel. "Human embryonic stem cell research : shaping regulations in Kuwait." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231070.

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8

Ke, Jin, and 柯金. "Transgenic stem cells for craniofacial bone reconstruction." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44362973.

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Bone loss from the cranio-maxillofacial region is a major clinical problem affecting patients worldwide. Conventional treatment strategy includes the use of autogenous or allogeneic bone, biomaterials, and osteogenic growth factors. However, there has been no effective therapy for most cases so far. Stem cell-based gene therapy is the latest research method with possible applications in humans. The present study aims to (1) characterize rabbit mesenchymal stem cells (MSCs) relating to growth pattern, surface antigens, and the potential for multi-differentiation; (2) determine the transduction

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9

Renszel, Krystal Marie. "USING MUTAGENESIS AND STEM CELLS TO UNDERSTAND RETROVIRAL NEUROVIRULENCE." Kent State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=kent1254659655.

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10

Sukhdeo, Kumar. "Defining immunophenotypic signatures of stem cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1373038255.

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11

Jacobs, Peter. "Immunohaematopoietic stem and progenitor cell transplantation - a thirty year prospective and systematic research investigation." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5232.

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12

Figueira, Edwin C. Medical Sciences Faculty of Medicine UNSW. "???Stem Cell Pathway??? gene expression in human foetal limbus and cadaveric human limbal epithelium." Awarded by:University of New South Wales. School of Medical Sciences, 2006. http://handle.unsw.edu.au/1959.4/27455.

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Stem cells play a vital role in the turn over of permanently self-renewing tissues (e.g. corneal epithelium, epidermis, bone marrow). Stratified cornea epithelia serve, as ideal tissue models for studying ???stemness???, as the site of cells in the different stages of differentiation are anatomically easily identifiable. Studies targeting limbal stem cell maintenance, in-vitro gene expression during storage and differentiation will benefit future therapeutic applications (e.g. corneal transplantation). Knowledge of stem cell behaviour will help explain the pathophysiology of corneal related oc

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13

Lause, Gregory E. "Testing for Osteogenic Potential of Human Mesenchymal Stem Cells." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1305310481.

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14

Calderone, Carli E. "Stem Cell Research: Science Education and Outreach." Miami University Honors Theses / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1268751337.

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15

Copland, Paul S., and n/a. "Embryonic stem cell research and the metaphysics of identity." University of Otago. Dunedin School of Medicine, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070914.141825.

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Embryonic stem cell research has the potential to revolutionise both the practice of medicine and our understanding of the human body. Although the usual technical and financial limitations of research apply, perhaps the greatest obstacle to the progress of this research at the present time is the ethical concerns surrounding the destruction of early human embryos. The established debate over the ethical significance of the early embryo has thus taken on renewed importance. Within biology stem cell research has begun to overturn some long held assumptions about the roles of genes and cellula

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16

Kim, Jin Young Leo. "METABOLIC CONTROL OF THE EPIGENOME IN GLIOBLASTOMA STEM CELLS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case157616602610095.

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17

Wang, Fangjing. "Biomedical Imaging of Stem Cells Using Reporter Genes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1261441999.

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18

Deng, Jie. "Neurogenesis of adult stem cells from the liver and bone marrow." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0009700.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 143 pages. Includes Vita. Includes bibliographical references.

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19

Chang, Hana. "Anisotropic Adaptation of Stem Cells to Changing Mechanical Environments." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1324013901.

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20

Guthrie, Steven Mitchell. "Hemangioblasts from hematopoietic stem cells to endothelial progenitor cells and their effector molecules /." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010068.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 95 pages. Includes Vita. Includes bibliographical references.

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21

Nortje, Nico. "The moral status of embryonic stem cell research in the South African context." Thesis, Stellenbosch : University of Stellenbosch, 2007. http://hdl.handle.net/10019.1/1372.

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Thesis (DPhil (Philosophy))--University of Stellenbosch, 2007.<br>Should surplus embryos which are destined to be discarded be protected at all cost, to the extent that they cannot contribute to medical knowledge - knowledge which could benefit society at large? Are embryos people or merely items of property? Different moral theories address these questions in different ways. Deontologists argue that the end never justifies the means and that the right not to be killed is more fundamental than the obligation to save. Utilitarians, on the other hand, argue that certain criteria should be met be

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22

Espinha, Nuno Miguel Moura. "Bioprocess engineering of induced pluripotent stem cells for application in cell therapy and pre-clinical research." Master's thesis, Faculdade de Ciências e Tecnologia, 2014. http://hdl.handle.net/10362/11551.

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23

Petluru, Vipula. "Selective modulation of PPARγ activities in marrow mesenchymal stem cells and their effects on bone". University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1310132031.

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24

Swaminathan, Ganesh. "Evaluation Of Adult Stem Cell Derived Smooth Muscle Cells For Elastic Matrix Regenerative Repair." University of Akron / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=akron1462209321.

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25

Oñate, Monje Lorena de 1985. "Research on cardiac differentiation from human pluripotent stem cells: how to get beating cells in a dish." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/398575.

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Probably, the gain in organ complexity and cell function has led to a decrease in healing capacities in the adult mammalian heart. In an effort to generate new venues for the generation of functional cardiac cells, in the present work we have explored the possibility to manipulate cell fate and plasticity making use of different technologies. First, and taking advantage of somatic cell reprogramming we have generated induced pluripotent stem cells (iPSCs) from umbilical cord derived mesenchymal stem cells (ucMSCs), an amenable source of stem cells in the clinical setting. In a very simple ma

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26

Santiago-Torres, Juan E. "Fetal Mesenchymal Stem Cells Achieve Greater Gene Expression in Vitro, but Less Effective Osteoinduction in Vivo than Adult Mesenchymal Stem Cells." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1404561922.

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27

Kandimalla, Yugandhar. "Study of Chitosan Microparticles with Bone Marrow Mesenchymal Stem Cells for Bone Tissue Regeneration." University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1250778129.

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28

江卓庭 and Cheuk-ting Kong. "Understanding the function of the Mll-een leukaemic fusion gene by embryonic stem cell approaches." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31244312.

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29

Joshi, Ramila Joshi. "Micro-engineering of embryonic stem cells niche to regulate neural cell differentiation." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1544029342969082.

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30

Baird, Janet W. "Molecular analysis of putative haemopoietic gene products derived from murine embryonal stem cells." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369024.

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31

Meriweather, Veronica. "Stem Cells Research for the Enhancement Cardiac Regeneration: The Current Role of Multi- and Pluri-Potent Cells in Injury Repair." Master's thesis, Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/159475.

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Physiology<br>M.S.<br>The study of cardiac regeneration can have many forms in which it is defined. It can not only be the ability to add new myocardium to dead or dying tissues, but also include the prevention of cardiac tissue degeneration, reversal of tissue remodeling, and the maintenance of systolic and diastolic function in the incidence of tissue damage, which can lead to subsequent heart failure progression. The use of stem cells for cardiac regeneration represents a growing field of new therapies for patients with end stage cardiac disease. Various studies have noted promising results

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32

Manninen, Bertha Alvarez. "When does a human being gain a moral right to life? an ethical and metaphysical study of abortion and embryonic stem cell research /." online access from Digital Dissertation Consortium, 2006. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?3251580.

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33

Campbell, Ian. "Optimization of Methods for Generating Customized Gene-Edited Human Pluripotent Stem Cells." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504802720510926.

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34

Chang, Chuan-Yuan Ally. "Analysis of Stem Cells and Wound Healing in the Human Cornea." Thesis, University of Auckland, 2009. http://hdl.handle.net/2292/4954.

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PURPOSE:The limbus of the cornea is said to be the niche for limbal stem cells (LSCs) and the primary source of corneal epithelial maintenance. In this model, adult corneal epithelial cells are maintained by LSCs that cycle slowly and give rise to transient amplifying (TA) cells. These migrate centripetally, differentiate outwards to the surface, and are then lost by desquamation. This study set out to investigate the stem cell properties of human corneal epithelium and their contribution towards corneal epithelial regeneration after wounding. METHODS: Frozen sections of human corneal t

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35

Sargent, Carolyn Yeago. "Effects of hydrodynamic culture on embryonic stem cell differentiation: cardiogenic modulation." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34710.

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Stem and progenitor cells are an attractive cell source for the treatment of degenerative diseases due to their potential to differentiate into multiple cell types and provide large cell yields. Thus far, however, clinical applications have been limited due to inefficient differentiation into desired cell types with sufficient yields for adequate tissue repair and regeneration. The ability to spontaneously aggregate in suspension makes embryonic stem cells (ESCs) amenable to large-scale culture techniques for the production of large yields of differentiating cell spheroids (termed embryoid b

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36

Bratt-Leal, Andrés Miguel. "Biomaterial integration within 3D stem cell aggregates for directed differentiation." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/45934.

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The derivation of embryonic stem cells (ESCs) has created an invaluable resource for scientific study and discovery. Further improvement in differentiation protocols is necessary to generate the large number of cells needed for clinical relevance. The goal of this work was to develop a method to incorporate biomaterial microparticles (MPs) within stem cell aggregates and to evaluate their use for local control of the cellular microenvironment for directed differentiation. The effects of unloaded MPs on ESC differentiation were first determined by controlled incorporation of poly(lactic-co-gl

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37

Jabero, Marvin Frank. "Investigation for the Identification of Transient Amplifying/Stem Cell Pool in Oral Mucosa." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1276788518.

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38

Morrison, Christa (De Swardt). "Human stem cell research : tracking media attention in time from 1998-2005." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/1043.

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Thesis (MA (Journalism))--University of Stellenbosch, 2006.<br>Moral questions arising from advances in science and technology are proliferating exponentially. Much controversy surrounds the ways in which biotechnology is used to eradicate a vast range of diseases and injuries. Stem cell research is one such way. Throughout the world stem cell research has been met with varying responses that range from opposition and criticism to approval and advocacy. As a result, it has attracted significant attention from the news media. The media have been accused of bias by focusing only on the controv

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39

Beligala, Dilshan Harshajith. "Stem-like cells and glial progenitors in the adult mouse suprachiasmatic nucleus." Bowling Green State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1566319291491512.

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40

Wray, Jason Patrick. "Characterisation of a novel culture condition for the establishment and maintenance of mouse embryonic stem cells and implications for the mechanisms of self-renewal." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3215.

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Pluripotency is defined as the ability of a cell to give rise to all the cell types of the adult organism. In vivo this property is possessed transiently by the cells of the epiblast in the developing embryo but it can be maintained indefinitely by deriving embryonic stem (ES) cells. How the pluripotent state is established in the cells of the early embryo and how it is ‘captured’ and maintained in the form of ES cells is a fascinating question for biology with practical implications. It is hoped that ES cells will be of use in biomedical research and cell replacement therapy. Our understandin

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41

DiVincenzo, Lola S. "DIRECTION OF INDUCED PLURIPOTENT STEM CELL DIFFERENTIATION BY ENDOTHELIAL CELL SECRETOME." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1438031276.

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42

Bhat, Samerna. "Impact of Nicotine and PPARd-agonist on Human Mesenchymal Stem Cells." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1366337315.

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43

Flavahan, William Alexander. "Glioma Stem Cells Adapt to Restricted Nutrition Through Preferential Glucose Uptake." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1384252748.

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44

Aggarwal, Reeva. "Mechanisms of Human CD34+ Stem Cell-Mediated Regulation of Osteoporosis in a Preclinical Model." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354637444.

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45

Witek, Rafal Piotr. "Novel application of gene therapy and somatic stem cells in treating metabolic liver disorders." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0009820.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 127 pages. Includes Vita. Includes bibliographical references.

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46

Kim, Saejeong. "USE OF ENDOTHELIAL-SPECIFIC PROMOTERS TO IDENTIFY AND SELECT DIFFERENTIATING STEM CELLS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1237483364.

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47

Samitsch, Marina. "Dissecting human haematopoietic progenitors." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:58511f8d-cb36-4acf-b706-c465c50f5404.

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Human haematopoiesis resembles a complex hierarchy, however most intermediate stages are only poorly defined. Efforts to characterise human progenitors have been inconsistent and failed to integrate previous knowledge. Furthermore, characterisation of normal progenitors has important implications in acute myeloid leukaemia (AML) biology. We previously established that leukaemic stem cells (LSCs) resemble the immunophenotypic progenitor compartments more closely than the stem cell fraction. Therefore, I set out to characterise human stem and progenitor cells (HSCPs) on phenotypic, molecular and

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48

Dunphy, Jaclyn Marie. "Infection of Neural Stem Cells with Murine Leukemia Viruses Inhibits Oligodendroglial Differentiation: Implications for Spongiform Neurodegeneration." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1334343584.

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49

Seriola, Petit Anna. "Pluripotent stem cells as research models: the examples of trinucleotide repeat instability and X-chromosome inactivation." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/325148.

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Els models de malalties són una eina bàsica per la comprensió de les malalties humanes. Actualment, la majoria de la informació de la que disposem de malalties humanes es basa en models animals. Tot i això, els models animals difereixen molecular i fenotípicament dels humans, i no sempre reprodueixen fidelment la malaltia humana. En les últimes dècades, les cèl·lules mare humanes s’han establert com una opció molt interessant en el camp de la modelització cel·lular. En aquest treball hem volgut caracteritzar les cèl·lules mare embrionàries com a models per a l’estudi de la inestabilitat de la

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50

Lam, Phuong T. "Crispr/cas9-mediated genome editing of human pluripotent stem cells to advance human retina regeneration research." Miami University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1575372014701457.

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