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Dissertations / Theses on the topic 'Stem cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Falk, Anna. "Stem cells : proliferation, differentiation, migration /." Stockholm, 2005. http://diss.kib.ki.se/2006/91-7140-497-X/.

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Meletis, Konstantinos. "Studies on adult stem cells /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-803-7/.

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3

Harun, Rosliah. "Derivation of trophoblast stem cells from human embryonic stem cells." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414643.

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4

Gilner, Jennifer Bushman Kirby Suzanne Lee. "Enrichment of therapeutic hematopoietic stem cell populations from embryonic stem cells." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1232.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pathology and Laboratory Medicine." Discipline: Pathology and Laboratory Medicine; Department/School: Medicine.

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5

Marshall, Gregory Paul. "Neurospheres and multipotent astrocytic stem cells neural progenitor cells rather than neural stem cells /." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010047.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 97 pages. Includes Vita. Includes bibliographical references.

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6

Eriksson, Malin. "Manipulating neural stem cells." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-853-2/.

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7

Gupta, Gunjan. "Effect of chondrocyte-stem cell interactions on chondrogenesis of mesenchymal stem cells." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1465607.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed August 11, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 128-134).

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8

Noisa, Parinya. "Characterization of neural progenitor/stem cells derived from human embryonic stem cells." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5712.

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Human embryonic stem cells (hESCs) are able to proliferate indefinitely without losing their ability to differentiate into multiple cell types of all three germ layers. Due to these fascinating properties, hESCs have promise as a robust cell source for regenerative medicine and as an in vitro model for the study of human development. In my PhD study, I have investigated the neural differentiation process of hESCs using our established protocol, identified characteristics associated with each stage of the differentiation and explored possible signalling pathways underlying these dynamic changes

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9

Beaver, C. M. "Clonogenicity and stem cells." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1400299/.

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Primary keratinocytes form 3 types of colony with different morphologies termed holoclones, meroclones and paraclones, thought to be derived from stem, early and late stage precursor cells respectively (Barrandon and Green, 1987b, Rochat et al., 1994). Cancer cell lines produce colonies with morphologies analogous to those of holoclones, meroclones and paraclones, and consequently holoclone morphology is used as a surrogate marker for stem cell colonies. The aim of this study was to elucidate the relationship between clonogenicity, colony morphology and stem cells. Colonies formed by primary p

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10

Luís, Ana Isabel Lopes. "Stem cells and Stroke." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/50130.

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11

Gorbatyuk, K., Наталія Ігорівна Муліна, Наталия Игоревна Мулина, and Nataliia Ihorivna Mulina. "Stem cells sidestep controversy." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/31100.

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Science and technology have utterly transformed human life in the past few generations. But big changes arrive faster and faster these days. Now we’re right on the verge of some extraordinary stuff. New techniques will circumvent ethical concerns, and maybe lead us to the Medical Holy Grail: the ability to grow new tissue and organs from the patient’s own cells, virtually eliminating the possibility of rejection. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/31100

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12

Luís, Ana Isabel Lopes. "Stem cells and Stroke." Dissertação, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/50130.

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13

Barennise, Arries. "Knowledge, perceptions and practices of members of the health care team involved in stem cell transplantations in the Western Cape." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2880.

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Thesis (MTech (Nursing))--Cape Peninsula University of Technology, 2017.<br>Stem cell transplantation has become one of the standard methods of treatment for patients with malignant and benign blood disorders. The multidisciplinary team interacting with these patients and their families, must be knowledgeable concerning the appropriate quality health care. The objectives of the study were to explore the knowledge of the members of the health care team in terms of the processes that need to be adhered to with stem cells transplantation, as well as exploring the perceptions amongst the health ca

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14

Li, Jing. "Effects of intrinsic & extrinsic factors on the growth and differentiation of human mesenchymal stem cells." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36434450.

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15

Yao, Hsin-Lei Reid Lola M. "The hepatic stem cell niche and paracrine signaling by mesenchymal cells in support of human hepatic stem cells." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1270.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biomedical Engineering." Discipline: Biomedical Engineering; Department/School: Medicine.

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16

Nadal-Melsio, Elisabet. "Regulatory T cells after allogeneic stem cell transplantation." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523746.

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17

Li, Victor Chun. "The Cell Cycle and Differentiation in Stem Cells." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10536.

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The relationship between cellular proliferation and differentiation is a major topic in cell biology. What we know comes from models of somatic cell differentiation, where it is widely viewed that cycling and differentiation are coupled, antagonistic phenomena linked at the G1 phase. The extension of this view to stem cells, however, is unclear. One potential possibility is that stem cells also tightly link their G1 phase with their differentiation, indicating a similarity between the differentiation of stem cells and the differentiation of more mature somatic cells. On the other hand, stem ce

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18

Mavin, Emily. "Regulatory T cells in haematopoietic stem cell transplantation." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2731.

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Graft-versus-host disease (GvHD) remains the main complication associated with haematopoietic stem cell transplantation (HSCT). GvHD is caused by allo-reactive donor T cells mounting an attack against specific target tissues. CD4+CD25HiFoxp3+ regulatory T cells have been shown to modulate GvHD in vitro and also in vivo animal models. More recently early stage clinical trials have described the successful use of Treg to reduce the incidence of GvHD following HSCT. The aim of this study was to investigate further the suppressive mechanisms by which Treg are able to modulate GvHD and assess the i

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19

Harrison, Sean. "Liver cell types derived from pluripotent stem cells." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/liver-cell-types-derived-from-pluripotent-stem-cells(7f39c3ec-facd-4c06-ab9a-7c171313eb05).html.

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Liver development involves the differentiation and interaction of both endoderm and mesoderm cell types. The role of the liver in drug metabolism makes it an important area of medical research. Mimicking embryonic liver development in vitro using human ESCs is a strategy used to differentiate liver cell types. These can then be used as a model playing a role in the development of drugs and the study of their hepatotoxicity and would also have potential for use in cell therapy and regenerative medicine. Differentiated hepatocyte-like cells were found to have more in common with liver cells than

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20

Kemp, Kevin Charles. "The role of mesenchymal stem cells in stem cell transplantation for haematological malignancies." Thesis, University of the West of England, Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495521.

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Haemopoietic recovery after high dose chemotherapy (HOC) in the treatment of haematological disease may be slow and/or incomplete. This is generally attributed to progressive haemopoietic stem cell failure, however we hypothesize that HOC induced defective haemopoiesis may be in part due to poor stromal function. Although chemotherapy is known to damage mature bone marrow stromal cells in-vitro, the extent to which marrow mesenchymal stem cells (MSC) are damaged by HOC in-vivo and in-vitro is unknown. To firstly address this question the physical characteristics and functional properties of ma

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21

Lin, Wenyu. "Investigating the immunomodulatory properties of human embryonic stem cell-derived mesenchymal stem cells." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/7060.

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The immunosuppressive property of mesenchymal stem cells (MSC) has been utilised to ameliorate autoimmune reactions such as graft-versus-host disease. However, variation exists in primary MSC isolated due to differences in donor age and tissue of origin. Alternatively, human embryonic stem cells (hESC) can be differentiated to homogeneous populations of MSC (hESCMSC), thus providing an unlimited source of MSC for cell therapy. In this study, the immunomodulatory properties of two hESC-MSC lines, hESC-MSC1 and hESC-MSC2, were compared with adult bone marrow-derived MSC (BM-MSC) and neonatal for

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22

Vicario, Nunzio. "Directly induced Neural Stem Cells transplantation and prospects for stem cell-based therapy." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/4088.

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Despite the remarkable beneficial effects of disease-modifying agents in relapsing-remitting multiple sclerosis (MS) patients, progressive forms of (P)MS still lack effective treatments. This stark contrast is partially dependent on the difficulties researchers have found in tackling the complex pathophysiology of this phase of disease, in which chronic inflammation within the central nervous system (CNS) is coupled by ongoing neurodegeneration and demyelination. Cell transplantation is among the most promising therapeutic approaches in regenerative medicine, combining tissue trophic and immun

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23

Bigdeli, Narmin. "Derivation, characterization and differentiation of feeder-free human embryonic stem cells /." Göteborg : Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg, 2010. http://hdl.handle.net/2077/22353.

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24

Zhang, Yuelin, and 張月林. "Mesenchymal stem cells derived from pluripotent stem cells for cardiovascular repair and regeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196438.

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Despite major advances in pharmacological and surgical treatments of cardiovascular diseases (CVDs), clinical outcomes of patients with severe CVDs remain very poor. Most of medication and interventions currently available are only playing roles of preventing further damage to myocardium, declining the risk of on-going cardiovascular events, lifting the cardiac pumping efficiency and lower early mortality rates, none of these treatments can regenerate or repair damaged cardiac tissue or restore heart function. As a result, several new strategies have been explored to overcome limitations of cu

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25

Götherström, Cecilia. "Characterisation of human fetal mesenchymal stem cells /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-139-3/.

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26

Zhang, Jiao, and 张姣. "Regulation of cell proliferation and modulation of differentiation in human induced pluripotent stem cell-derived mesenchumal stem cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617503.

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Functional mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (iPSCs) may represent an unlimited cell source with superior therapeutic benefits for tissue regeneration to somatic tissue, such as bone marrow (BM)-derived MSC. In the first part of this project, I investigated whether the differential expression of ion channels in iPSC-MSCs was responsible for their higher proliferation capacity than that of BM-MSCs. The expression of ion channels for K+, Na+, Ca2+ and Cl- currents was assessed by reverse transcription-polymerase chain reaction (RT-PCR). The function

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27

Piccoli, Martina. "Mouse amniotic fluid stem cells are able to differentiate into satellite cells replenishing the depauperated muscle stem cell niche." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423564.

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Introduction: Stem cell biology has received much interest because of its potential in both therapeutic application and in vitro modeling of diseases. In particular embryonic stem cells have good proliferative and differentiative abilities, but their use is still associated to ethical concerns and problems related to their teratogenic potential. Adult stem cells have also been described to be pluripotent both in vitro and in vivo. However, their use is limited because they are difficult to isolate and expand, particularly in a clinical setting. In this scenario, it would be advantageous to obt

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28

McGarvey, Alison Clare. "Genome-wide transcriptional characterisation and investigation of the murine niche for developing haematopoietic stem cells." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28741.

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Haematopoietic stem cells (HSCs) are capable of differentiation into all mature haematopoietic lineages, as well as long-term self-renewal and are consequently able to sustain the adult haematopoietic system throughout life. Currently, in the mouse, HSCs are understood to first appear in the aorta-gonad-mesonephros (AGM) region at embryonic day 11 via a process of maturation from precursors (pre-HSCs). This maturation within the AGM region involves the complex interplay of signalling between cells of the niche and maturing precursor cell populations, but is relatively little understood at a mo

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29

Sethia, Pavan P. "Development and Commercialization of Menstrual Blood Stem Cells Banking." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1303759438.

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30

Sarvi, Sana. "Small cell lung cancer and cancer stem cell-like cells." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9542.

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Small cell lung cancer (SCLC) is a highly aggressive malignancy with extreme mortality and morbidity. Although initially chemo- and radio-sensitive, almost inevitable recurrence and resistance occurs. SCLC patients often present with metastases, making surgery not feasible. Current therapies, rationally designed on underlying pathogenesis, produce in vitro results, however, these have failed to translate into satisfactory clinical outcomes. Recently, research into cancer stem cells (CSCs) has gained momentum and form an attractive target for novel therapies. Based on this concept, CSCs are the

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31

Ismail, Siti N. "Stem cell bioprocessing : the bioengineering of lung epithelium in 3D from embryonic stem cells." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/9013.

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Stem cell therapies and tissue engineering strategies are required for the clinical treatment of respiratory diseases. Previous studies have established protocols for the differentiation of airway epithelium from stem cells but have involved costly and laborious culture methods. The aim of this thesis was to achieve efficient and reproducible maintenance and differentiation of embryonic stem cells to airway epithelium, in 2D and 3D culture, by developing appropriate bioprocessing technology. Firstly, the 2D differentiation process of human and murine ES cells into pulmonary epithelial cells wa

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32

Anilkumar, Thapasimuthu Vijayamma. "The pathobiology of hepatic stem cells (oval cells)." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244072.

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33

Samadikuchaksaraei, Ali. "Derivation of pulmonary epithelial cells from stem cells." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422341.

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34

Tseng, Paulina, and Oscar Hedlund. "Dental Mesenchymal Stem Cells’ Effect on Glioma Cells." Thesis, Umeå universitet, Institutionen för odontologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131189.

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Glioma is a malignant tumor with a high mortality rate within few years of diagnosis. Due to limited effect of currently available cancer therapies, alternative therapies are investigated. Studies have shown that mesenchymal stem cells (MSCs) may have a therapeutic potential in glioma treatment. The objective of this in-vitro study was to examine the effect of three different human dental MSCs (D-MSC) on rat glioma cells. We utilized three experimental set ups in order to study the effect of D-MSC on glioma cell survival: unstimulated conditioned medium, stimulated conditioned medium, and dire

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35

Goddard, Nicola. "Manufacture of red blood cells from stem cells." Thesis, Heriot-Watt University, 2017. http://hdl.handle.net/10399/3271.

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Although the current system of blood transfusion is relatively safe and established within the UK, periodic shortages of certain blood groups and residual risks of emerging transfusion transmitted infections (TTIs) make an industrial manufacture process for the generation of red blood cells more desirable. The generation of red blood cells from human embryonic stem cells has been completed in vitro but the major challenge lies in making the process highly scalable and economically viable. Initially human embryonic and induced pluripotent stem cells were trialled for use on the project however

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36

Rojas, Angela M. "Characterization of endometrial stem cells." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1473654.

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37

Wiblin, Annie E. "Nuclear organisation in stem cells." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/25309.

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If nuclear organisation regulates gene expression, then it may have a role in gene silencing as a cell commits to differentiation. It is therefore important to determine the nuclear organisation of stem cells. Here I ask if the nuclear architecture of human and mouse embryonic stem (ES) cells is different from that of differentiated cells? I have examined the position of chromosomes 18 (gene-poor) and 19 (gene-rich) and show that their radial nuclear organisation, seen in differentiated cells, is already established in human ES cells. However, I show that the position of centromeres is differe

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38

Hall, P. E. "Integrins and neural stem cells." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599860.

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Extracellular matrix (ECM)-rich basal laminae are an important component of other stem cell niches and thus are likely to form part of the NSC niche. Interactions with the ECM are mediated manly by cell surface heterodimers called integrins. β1 integrins have been implicated in maintaining human epidermal stem cells, and their elevated expression has allowed the enrichment of human prostate epithelial stem cells from transit amplifying populations. My work has focused on the role of the ECM and its receptors in the mammalian CNS stem cell niche. Initial experiments examined the conditions nece

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39

Modino, Sonie Alix Carmen. "Stem cells and tooth development." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444559.

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40

Karystinou, Alexandra. "YAP in mesenchymal stem cells." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=192255.

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MSCs are the most studied subtype of adult stem cells and have been derived from most postnatal organs and tissues. MSCs are defined as having the capacity to self-renew and to differentiate into both mesodermal and non-mesodermal lineages, and are immunosuppressive. For these properties, MSCs have been considered ideal candidates for regenerative medicine and have been used in several clinical trials. The difficulty, however, to preserve the potency of the cells during culture expansion and to monitor differentiation are obstacles in their use in the clinic and have emphasized the need to inv

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41

Ma, Jun. "Characterization of Neuroblastoma Stem Cells." University of Toledo Health Science Campus / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=mco1147791167.

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42

Hahnel, Mark. "Trafficking of mesenchymal stem cells." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/14559.

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In adult life mesenchymal stem cells (MSCs) reside primarily in the bone marrow and are defined according to their ability to self-renew and differentiate into tissues of mesodermal origin. Due to their immuno-modulatory properties and ability to form cartilage and bone, MSCs have clinical potential, for the treatment of autoimmune diseases and tissue repair. This project determines the chemokine receptor profile on murine bone marrow MSCs at early and late passage and on human MSCs derived from a range of fetal tissues including fetal blood, bone marrow, amniotic fluid and placenta. The overw

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43

Tomaszczuk-Kossowska, Katarzyna. "Stem cells in the ovary /." [S.l.] : [s.n.], 2009. http://edoc.unibas.ch/diss/DissB_8727.

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Shaharuddin, Bakiah Binti. "Characterisation of limbal stem cells." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/4044.

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The cornea is the anterior most structure at the front of the eye and its most important function is to transmit light to the retina for a clear vision. The external surface of the cornea is composed of an epithelium which is continuous with the surrounding conjunctiva. The corneal limbus forms the narrow transition zone between the corneal and conjunctival epithelia and is believed to harbour the cornea stem cells. Limbal stem cell (LSC) deficiency (LSCD) is a painful and blinding condition of the eye. The recent technique of ex vivo expansion of healthy autologous limbal epithelia for transp

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45

Skinner, Elizabeth Mary. "Pluripotent stem cell-derived endothelial cells for vascular regeneration." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/15865.

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Background: Vascular endothelial dysfunction plays a major role in the pathogenesis of atherosclerosis. As such, the study of endothelial cells has sought to identify causal pathways and novel therapeutic approaches to promote vascular repair. Induced pluripotent stem (iPS) cell technology may be a particularly useful tool, and could be used to derive endothelial cells and their progenitors from individuals with endothelial dysfunction to explore these pathways and develop novel strategies for vascular regeneration. Whilst iPS cells are conventionally obtained from the reprogramming of dermal

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Prater, Michael David. "Progenitor and stem cell potential of mammary myoepithelial cells." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648364.

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Giraddi, Rajashekharagouda. "Cell cycle kinetics of mammary stem and progenitor cells." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607789.

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48

Costa, Vânia Marta Simões. "Recuperação do sistema nervoso central: o potencial das células estaminais." Bachelor's thesis, [s.n.], 2011. http://hdl.handle.net/10284/2480.

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Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciado em Análises Clínicas e Saúde Pública<br>Esta monografia teve como objectivo, verificar o estado da arte no que se refere à utilização de células estaminais no tratamento de lesões e de doenças degenerativas do sistema nervoso central. Foram abordados ao longo deste trabalho de revisão, alguns aspectos fundamentais, descritos em diversos artigos científicos de âmbito internacional que definem o estado actual do desenvolvimento de terapias de recuperação do sistema nervoso centr

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49

Nortjé, Nico. "The moral status of embryonic stem cell research in the South African context /." Link to the online version, 2007. http://hdl.handle.net/10019.1/1372.

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50

Pierret, Chris. "Characterization of an in vitro neural stem cell niche with educational component Stem cells and society /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/6054.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2008.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on August 3, 2009) Vita. Includes bibliographical references.

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