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Dissertations / Theses on the topic 'Stem tumors'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Hertwig, Falk [Verfasser]. "Development of brain tumors from neural stem, progenitor cells / Falk Hertwig." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1027308503/34.

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2

French, Rhiannon. "The role of cFLIP in breast cancer stem cells." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/68201/.

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Breast tumours have intrinsic heterogeneity. The cancer stem cell hypothesis is currently challenging the notion that all cancer cells are equally malignant, suggesting that it is important to evaluate the efficacy of potential anti-cancer drugs by their ability to target the stem-like population. TRAIL is a cytotoxic agent the efficacy of which has been limited by a lack of patient stratification in clinical trials (Lemke 2014). In pre-clinical studies TRAIL has shown specificity towards mesenchymal-like breast cancer cell lines (Rahman et al. 2009) We show here that TRAIL is able to target t

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3

Carruthers, Ross David. "Response to ionising radiation of glioblastoma stem-like cells." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/7022/.

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Introduction: Glioblastoma (GBM) is characterised by local recurrence following surgery, radiotherapy and chemotherapy. GBM has a poor prognosis and novel approaches are required. Recently, a hierarchical organisation of tumour cells in GBM has been proposed. This hypothesis suggests only a subset of cancer cells, termed ‘cancer stem-like cells’ (CSCs) drive tumour growth and possess properties of self renewal and unlimited proliferative capacity. CSCs have been described as radioresistant, implicating CSCs as a determinant of tumour recurrence following therapy. Therefore improved patient out

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4

Illhardt, Toni [Verfasser]. "Stem Cell Transplantation for Relapsed or Refractory Pediatric Solid Tumors / Toni Illhardt." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1234450844/34.

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5

Yamaga, Yuichi. "Gene expression profile of Dclk1+ cells in intestinal tumors." Kyoto University, 2019. http://hdl.handle.net/2433/236595.

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6

Jong, Jeroen de. "Stem cell marker OCT3/4 in biology and diagnostics of Germ cell tumors." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10637.

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7

Wang, Hui [Verfasser], and Claudia [Akademischer Betreuer] Lengerke. "Characterization of Stem Cell Genes in Solid Tumors / Hui Wang ; Betreuer: Claudia Lengerke." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1199945153/34.

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8

McLarnon, Andrew. "Cellular mechanisms of alloreactive immunity following stem cell transplantation." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3064/.

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Allogeneic stem cell transplantation is associated with a powerful T cell-mediated ‘graft-versus-leukaemia’ (GvL) effect and also ‘graft-versus-host disease’ (GvHD). Developing therapies to improve survival relies on greater understanding of these responses in order to enhance GvL and suppress GvHD. To gain an increased understanding of the mechanisms of GvHD I measured frequencies of Th1, Th17 and Treg subsets in the blood of 32 GvHD patients (during and outside of disease episodes) and in 21 patients who did not suffer GvHD. No associations between T cell subset frequencies or serum cytokine

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9

Maggs, Luke. "The role of stem cell graft derived natural killer cells in regulating patient outcomes from allogeneic haematopoietic stem cell transplantation." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8633/.

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Myeloid and lymphoid malignancies are potentially curable through a graft versus leukaemia (GvL) effect following allogeneic haematopoietic stem cell transplantation. Whilst donor T cell are thought to be the main mediators of GvL, the effect of donor NK cells within HLA matched T cell depleted transplant setting is more unclear. Patient blood samples were analysed during the first month post-transplant, with higher reconstitution of NK cells at two weeks conferring a relapse protection association. Donor stem cell graft samples, from which NK cells within the patient at two weeks are thought

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10

Punjaruk, Wiyada. "The contribution of drug resistant cancer stem cells to paediatric brain tumours." Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/13403/.

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Introduction: Recent studies have revealed that cancer stem cells (CSCs) exist in malignant disease. Additionally, it is proposed that these cells may survive following chemotherapy, and hence contribute to tumour relapse. A significant mechanism of drug resistance in CSCs is believed to be the expression of ATP-binding cassette (ABC) transporters that efflux cytotoxic agents out of cells. The objective of this study was to study the existence of CSCs in a panel of primary paediatric brain tumours (PBTs) and to determine if these were drug resistant via functional ABC transporters. Materials a

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11

Young, Madeleine. "The effects of aberrant Wnt signalling on the murine intestinal stem cell compartment." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/53683/.

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Colorectal cancer is the 2nd most common cause of death by cancer in the UK, but it is treatable if diagnosed early. In order to increase the likelihood of early diagnosis, more must be understood about the early stages of colorectal tumourigenesis. It is known that intestinal stem cells (ISCs) are the cells of origin of colorectal tumourigenesis, and that an expansion of undifferentiated cell types, akin to ISCs, is one of the earliest events in mouse models of tumourigenesis. This indicates the importance of the relationship between the ISC compartment and tumourigenesis. In order to underst

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12

Zhang, Huijuan. "PKB/PAK4 and stem cell related signaling pathways in gestational trophoblastic disease." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B44249937.

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13

Zhang, Huijuan, and 张慧娟. "PKB/PAK4 and stem cell related signaling pathways in gestational trophoblastic disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44249937.

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14

Jackson, Thomas Robert. "Role of stem cell transcription factors in the response of tumour cells to DNA damage." Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/375047/.

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15

Zhu, Qionghua. "Wnt/beta-catenin signaling modulates salivary gland tumors and cancer stem cells by epigenetic mechanisms." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17597.

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Wnt/beta-Catenin-Signalgebung hat große Bedeutung für die Initiation und Progression verschiedener Krebsarten. Unser Labor hat kürzlich ein Mausmodell für Squamöse Speicheldrüsen-Karzinome etabliert, das menschliche Hals-Nasen-Ohren-Karzinome reflektiert, durch kombinierte Mutationen von beta-Catenin und dem Bmp-Rezeptor 1a. Diese Tumore enthielten hohen Level von sich selbst-erneuernden Krebs-Stammzellen. Behandlung mit den Wnt-Inhibitoren ICG-001 blockierte die Selbsterneuerung und induzierte die Differenzierung der Krebs-Stammzellen. In den Krebs-Stammzellen der Maus wurde eine globale Aufr

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16

Rachakatla, Rajashekar. "Targeted use of umbilical cord matrix stem cells for cancer therapy." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/547.

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17

Uyar, Ramazan [Verfasser], and Rainer [Akademischer Betreuer] Glaß. "Glioma-associated mesenchymal stem cells have profound effects on brain tumors / Ramazan Uyar ; Betreuer: Rainer Glaß." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1202011683/34.

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18

Herasymenko, O. S., V. I. Smolanka, A. V. Smolanka, and S. Sechko. "Intraoperative neurophysiological monitoring at stem-cell tumors surgical treatment: prognostic value for patients' further physiotherapeutic rehabilitation." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/63560.

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Investigation of the intraoperative neurophysiological monitoring effectiveness (motor and somatosensory induced potentials, spontaneous and trigger electroneuromyography) in surgical treatment of patients with stem-cell tumors<br>Badanie skuteczności monitorowania śródoperacyjnego neurofizjologicznego (potencjały indukowane silnymi i somatosensorowymi, spontaniczna i wyzwalająca elektroneuromiografia) w chirurgicznym leczeniu pacjentów z guzami komórek macierzystych.

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19

Korfi, Koorosh. "Epigenetic programming defines stem cell identity and entry into the proliferative compartment in chronic myeloid leukaemia (CML)." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3929/.

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Chronic myeloid leukaemia (CML) is a haematological malignancy that is identified by the presence of a fusion oncogene, BCR-ABL1, which is a constitutive tyrosine kinase. The discovery of tyrosine kinase inhibitors (TKIs) over that past decade has resulted in significantly improved survival rates and disease management in CML patients. However, a subpopulation of BCR-ABL1+ cells in the niche are found which exhibit stem cell-like features, such as self-renewal and quiescence. These CML stem cells (LSCs) are shown to be insensitive to TKI treatment and are capable of deriving the disease during

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20

Fanlo, Escudero Lucía. "Neuroblastoma cancer stem cells: The role of NXPH1 and its receptor α-NRXN1". Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668504.

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Neuroblastoma (NB) is a devastating paediatric cancer that originates in the developing sympathetic nervous system. These tumours account for 40% of the cases of cancer diagnosed during the first year of life and 8% of the cases detected overall during childhood. They show a striking clinical diversity, ranging from spontaneous remission to fatal metastatic dissemination. To optimize therapeutic approaches, NB patients have been stratified into risk groups. For the high risk (HR} patients, the 5 years overall survival probability remains below 30-40%. The failure to successfully treat these HR

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21

Irvine, David Arthur. "Defining novel therapeutic targets in chronic myeloid leukaemia stem cells : targeting self-renewal through hedgehog pathway inhibition." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4584/.

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22

Fernández, Flores Francisco. "The cancer stem cell hypothesis in spontaneous canine gliomas: from tumors to neurogenesis in the adult dog." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400385.

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Las células madre cancerosas (CSCs) se pueden originar tanto por la transformación de las células madre normales como a partir de progenitores o células diferenciadas con capacidad de auto-renovación. La hipótesis de las CSCs propone que una subpoblación específica de células es la responsable de mantener el tumor. Esta hipótesis se ha demostrado en una amplia variedad de tumores, incluidos los gliomas. Nestina y CD133 se utilizan como marcadores para la detección de las células madre neurales. En el presente estudio, un total de 20 tumores caninos fueron diagnosticados histopatológicamente co

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23

Mahller, Yonatan Y. "Development of Oncolytic HSV-1 as an Anticancer Therapeutic for Extracranial Neural Tumors and Cancer Stem Cells." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1190588795.

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24

Zachariah, Roshini. "An examination of the relationship between epithelial to mesenchymal transition and cancer stem cells in solid tumors." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12252.

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Thesis (M.A.)--Boston University<br>This thesis examines the connection between epithelial to mesenchymal transition (EMT) and cancer stem cells (CSC) in solid tumors. Epithelial to mesenchymal transition describes the conversion of cancer cells from an adherent, differentiated, and polar phenotype (epithelial) to a motile, plastic, and apolar phenotype (mesenchymal). EMT is correlated with metastasis; EMT is usually measured by QRT-PCR or immunohistochemistry. Cancer stem cells are thought to be responsible for metastasis and recurrence. They have been found in almost all solid tumors and can

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25

Chakupurakal, Geothy. "Preclinical studies of adenovirus-specific T-cells for adoptive transfer to haemopoietic stem cell transplant recipients." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2883/.

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Allogeneic stem cell transplantation (SCT) is the only curative treatment option for many haematological malignancies. Adenovirus (Ad) infections are a significant cause of morbidity and mortality post SCT. Lack of effective anti-viral treatment for Ad disease has led to the development of adoptive immunotherapy of Ad-specific T-cells as a promising therapeutic option for patients in this setting. The aim of this project was to establish preclinical criteria for the development of a clinical trial comparing two T-cell enrichment methods- multimer selection and cytokine secretion selection to e

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26

Leong, Yeh Chwan. "Reprogramming to cancer induced pluripotent stem cells elucidates the contribution of genetic and epigenetic alterations to breast carcinogenesis." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/53330/.

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The induced pluripotent stem cells (iPSCs) technology has revolutionized disease modelling by enabling the generation of patient-specific pluripotent stem cells for the study of complex disorders such as cancer. Somatic cell reprogramming through iPSCs induces global epigenetic reconfiguration of the chromatin which converts cancer cells to an embryonic stem cell-like state with potential reversion of tumorigenicity. Therefore, reprogramming can be used to answer the question as to whether epigenetic alterations alone can be sufficient to induce carcinogenesis, independent of genetic defects.

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27

Gallipoli, Paolo. "Investigation of the role of autocrine and paracrine growth factors in the survival and proliferation of chronic myeloid leukaemia stem and progenitor cells." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4172/.

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Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder arising in a haemopoietic stem cell (HSC) as a result of the reciprocal translocation between the long arms of chromosomes 9 and 22 (t9;22), leading to the formation of the fusion oncogene BCR-ABL. BCR-ABL has constitutive tyrosine kinase (TK) activity which drives, at least during the chronic phase (CP) of the disease, myeloid progenitor cells expansion through terminally differentiated cells and is necessary for the transformed phenotype. The introduction at the end of the last century of BCR-ABL TK inhibitors (TKI) has

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28

Hayward, Olivia A. "Design and synthesis of molecular inhibitors of cFLIP activity as a therapeutic strategy to target breast cancer cells and cancer stem-like cells." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/86899/.

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Tumour Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) is a known anti-cancer agent which exhibits cancer cell specificity. Its efficacy in breast cancer is limited, however, as illustrated by the resistance demonstrated in a number of cell lines. Cellular FLICE-Like Inhibitory Protein (c-FLIP) has been demonstrated to play a key role in TRAIL resistance in these cell line models, through its competitive interference with caspase-8 recruitment to the death inducing signalling complex (DISC). Our lab has demonstrated that breast cancer 'stem cells', the cells proposed to be responsibl

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29

Flores, Catherine T. "Characterization of a stem cell population derived from human peripheral blood and its therapeutic potential in brain tumors." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/4349.

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Adherent CD34+ cells are a stem cell enriched population with a high frequency of primitive stem cells that are genetically primed to differentiate into tissue-specific lineages. These cells make up the adherent CD34+ cells in peripheral blood which are the focus of this study. The first aim of this study was to transcriptionally characterize adherent CD34+ cells relative to nonadherent CD34+ cells using a whole human genome Affymetrix U133 plus 2 array. The subsequent analysis demonstrated transcriptional differences in genes which are involved in quiescence, cell cycle, homing and adhesion,

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30

Genovese, Sara. "Emergence and regulation of cell hierarchy in a Drosophila model of neuro-developmental tumor." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0482.

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Dans les tumeurs hiérarchiques, les cellules souches du cancer (CSC), au sommet de la hiérarchie tumorale, peuvent s'auto-renouveler et se différencier en progéniteurs amplificateurs transitoires (TAP) avec un potentiel d'auto-renouvellement limité. Au cours du développement, les cellules souches neurales de Drosophile, appelées neuroblastes (NB), expriment en séquence deux protéines antagonistes se liant à l'ARN, Imp et Syncrip (Syp), qui respectivement favorise et réprime l'auto-renouvellement des NB. La perturbation de mécanismes de division asymétrique des NB peut générer leur amplificatio

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31

Port, Rebecca. "Epstein-Barr virus induction of the hedgehog signalling pathway imposes a stem cell-like phenotype on human epithelial cells : implications for the pathogenesis of nasopharyngeal carcinoma." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5013/.

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Nasopharyngeal carcinoma (NPC) is endemic in Southern China and South East Asia, causally linked to Epstein-Barr virus (EBV) infection, and frequently shows dysregulation in a number of stem cell maintenance signalling pathways. This thesis has endeavoured to investigate the status of one of these pathways; the Hedgehog (HH) signalling pathway, in NPC tumours, and reveals the novel finding that EBV is able to active the HH signalling pathway through autocrine induction of the SHH ligand in the C666.1 authentic EBV-positive NPC-derived cell line and latently infected epithelial carcinoma cell l

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32

Bielecki, Peter. "Advanced Mesoporous Silica Nanoparticles for the Treatment of Brain Tumors." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case159558503832021.

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33

Suwala, Abigail Kora [Verfasser]. "Targeted glioma stem cell depletion through pharmacological WNT inhibition as a novel therapy for malignant brain tumors / Abigail Kora Suwala." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2019. http://d-nb.info/1190884062/34.

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34

Knoop, Kerstin. "Molecular imaging and radionuclide therapy in non-thyroidal tumors after mesenchymal stem cell- mediated sodium/iodide symporter (NIS) gene transfer." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-178550.

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35

Engel, Høi-Hansen Christina. "Application of stem cell markers in search for neoplastic germ cells in dysgenetic gonads, extragonadal tumors, and in semen of infertile men /." Copenhagen : Univ. Copenhagen, Fac. of Health Sciences, 2008. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016356357&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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36

Zayed, Hebatalla [Verfasser], Iver [Gutachter] Petersen, Peter [Gutachter] Elsner, and Alexander [Gutachter] Marx. "Stem cell transcription factor SOX2 in synovial sarcoma and other soft tissue tumors / Hebatalla Zayed ; Gutachter: Iver Petersen, Peter Elsner, Alexander Marx." Jena : Friedrich-Schiller-Universität Jena, 2019. http://d-nb.info/120588419X/34.

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37

Anderson, Bethany. "'Home sick' : exploring the impact of receiving a volunteer unrelated donor haematopoietic stem cell transplant far from home on the perceived coping of patients residing in the NHS Highland region." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6689/.

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This project aims to gather the experiences of patients living within the NHS Highland region who have travelled to Glasgow to receive their allogeneic haematopoietic stem cell transplant. It examines the effects of travelling long distances and remaining away from home for treatment, on coping. The project used a qualitative design, looking retrospectively at participants’ experiences. Semi-structured interviews were audio-recorded and transcribed verbatim before being analysed using Interpretive Phenomenological Analysis. Results of the analysis indicated ten super-ordinate themes: Impact of

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38

Cagnet, Stéphanie. "Etude du rôle des intégrines liant la laminine dans le développement et la tumorigenèse mammaires." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T079/document.

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Le développement de traitements thérapeutiques du cancer du sein reste limité par le niveau de connaissance des mécanismes moléculaires et cellulaires impliqués lors du développement normal et tumoral de la glande mammaire. L’épithélium mammaire est entouré d’une matrice extracellulaire (MEC) organisée, la membrane basale, dont le constituant principal est la laminine. Des études ont montré que les interactions entre les cellules mammaires et la MEC, dépendantes des intégrines, jouent un rôle majeur dans le développement et la tumorigenèse mammaires. Ces études n’ont cependant pas permis de dé

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39

Schug, Christina [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Advanced mesenchymal stem cell-mediated gene delivery of the theranostic sodium iodide symporter (NIS) in non-thyroidal tumors / Christina Schug ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1188564315/34.

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Schug, Christina [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Advanced mesenchymal stem cell-mediated gene delivery of the theranostic sodium iodide symporter (NIS) in non-thyroidal tumors / Christina Schug ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1173616195/34.

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Knoop, Kerstin [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Molecular imaging and radionuclide therapy in non-thyroidal tumors after mesenchymal stem cell- mediated sodium/iodide symporter (NIS) gene transfer / Kerstin Knoop. Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1065180403/34.

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Zhu, Qionghua [Verfasser], Walter [Gutachter] Birchmeier, Ann [Gutachter] Ehrenhofer-Murray, and Achim [Gutachter] Leutz. "Wnt/beta-catenin signaling modulates salivary gland tumors and cancer stem cells by epigenetic mechanisms / Qionghua Zhu ; Gutachter: Walter Birchmeier, Ann Ehrenhofer-Murray, Achim Leutz." Berlin : Lebenswissenschaftliche Fakultät, 2016. http://d-nb.info/1115767569/34.

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Alves, MarkÃnia KÃlia Santos. "Identifying of molecular alterations associated to expression of CD133, CXCR4, CD44 and OLIG2 and CDKN2A methylation in promoter in astrocytic tumors." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14421.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>Tumores sÃo populaÃÃes celulares heterogÃneas hierarquicamente organizadas, cujas cÃlulas-tronco possuem importÃncia relevante desde que sÃo cÃlulas com a capacidade de se renovarem e de gerarem linhagens em fases diferentes. Dada a sua importÃncia, a identificaÃÃo de componentes de cÃlulas-tronco Ã essencial para o entendimento da tumorigÃnese. Apesar de marcadores de linhagem neural terem sido identificados, a associaÃÃo destes marcadores com os tumores c

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Kraus, Christiane [Verfasser], and Peter [Akademischer Betreuer] Nelson. "Engineered mesenchymal stem cells as therapeutic vehicles for the treatment of solid tumors : Wnt and hedgehog biology-based targeting and transgene expression / Christiane Kraus ; Betreuer: Peter Nelson." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1164377086/34.

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45

Bernat, Peguera Adrià. "Mecanismos moleculares que regulan el crecimiento, la metástasis y la resistencia a terapias del carcinoma escamoso de piel." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667605.

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La mayoría de los carcinomas escamosos de piel (cSCCs) se tratan con éxito mediante escisión quirúrgica. Sin embargo, el 5-8% de los casos desarrollan recurrencias, las cuales están asociadas a un crecimiento agresivo, progresión de la enfermedad y una limitada supervivencia de los pacientes. Actualmente, los cSCCs avanzados, recurrentes y/o metastásicos son tratados con quimioterapia y radioterapia con escasos beneficios clínicos, y no se dispone de terapias dirigidas aprobadas para este tipo de tumores. El objetivo principal de esta tesis es identificar los mecanismos responsables del crecim

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46

Salb, Nicole [Verfasser], та Peter [Akademischer Betreuer] Nelson. "Application of engineered mesenchymal stem cells as therapeutic vehicles for the treatment of solid tumors : HIF1α-based targeting and the influence of thyroid hormones / Nicole Salb ; Betreuer: Peter Nelson". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1171131372/34.

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47

Grandi, Fabrizio. "Perfil fenotípico de potenciais células iniciadoras tumorais no tumor venéreo transmissível canino ex vivo." Botucatu, 2016. http://hdl.handle.net/11449/136206.

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Orientador: Noeme Sousa Rocha<br>Resumo: O tumor venéreo transmissível (TVT) canino é uma neoplasia transplantável, considerada um alo-enxerto. Entretanto, pouco se sabe a respeito da origem e processo de cacinogênese. Atualmente, postula-se que alguns tumores originem-se de células iniciadoras tumorais, classicamente descritas nas leucemias mielóide humanas. As características intrínsecas do TVT fornecem indícios de uma possível participação de células iniciadores tumorais no processo de carcinogênese nesse tumor. Foi realizado estudo de fenotipagem do TVT canino para avaliar a marcação das p

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Grandi, Fabrizio [UNESP]. "Perfil fenotípico de potenciais células iniciadoras tumorais no tumor venéreo transmissível canino ex vivo." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/136206.

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Hentschke, Patrik. "Anti-tumour effect in solid tumours, tolerance and immune reconstitution after allogeneic haematopoietic stem cell transplantation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-800-9/.

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Janich, Peggy 1981. "The role of circadian rhythms in epidermal homeostasis." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/84112.

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The natural daily cycles of light and dark have played a fundamental role in shaping the development of an adaptive intrinsic clock mechanism which allows organisms to coordinate the function of multiple organs by setting the correct circadian timing of cellular processes ensuring proper homeostasis. In mammalian skin, homeostasis is maintained by epidermal stem cells (epSCs). EpSCs localize to specialized niches where they undergo cycles of quiescence and proliferation. Several pathways are known to play essential rol

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