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Journal articles on the topic 'StemCell'

Author: Grafiati

Published: 9 March 2023

Last updated: 19 July 2025

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1

Brower, Vicki. "CT turns focus to StemCell." Nature Biotechnology 17, no. 9 (1999): 838. http://dx.doi.org/10.1038/12794.

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2

Ciment, J. "US Congress debates stemcell research." BMJ 318, no. 7178 (1999): 215. http://dx.doi.org/10.1136/bmj.318.7178.215b.

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3

De Oliveira, Cristiana Dias, Sudivan Vieira, Flávia dos Santos Lugão De Souza, et al. "Stemcell therapy for cardiology: a new path to humanity and a new care for nurse - a case report." Online Brazilian Journal of Nursing 4, no. 1 (2005): 2–8. http://dx.doi.org/10.17665/1676-4285.20054783.

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During the process of care of patients who suffered acute myocardial infarction we observed how complex is this disease. Nowadays, stemcell therapy opens a new horizon and hope for these patients. We conducted this study to improve our knowledge as nurses in face of this new therapeutic model. This study is a case report of a patient who suffered an anterior acute myocardial infarction and was admitted in a coronary care unit and enrolled in stemcell transplantation study protocol. The nurse has a fundamental role in the process of care during the hospitalization period clarifying the patient’

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4

Mhashilkar, Abner, and Anthony Atala. "Editorial: Effective Bio-EconomicApproaches for StemCell Therapy and Regenerative Medicine." Current Stem Cell Research & Therapy 7, no. 1 (2012): 1. http://dx.doi.org/10.2174/157488812798483430.

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5

Stephens, M. "1146 Quality of life after stemcell transplantation — a qualitative study." European Journal of Cancer Supplements 1, no. 5 (2003): S348. http://dx.doi.org/10.1016/s1359-6349(03)91172-4.

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6

Sabo, Peter, Vahagn Makaryan, Tanoya Poulsen, et al. "CRISPR Mediated ELANE Single-Allele Knock-out Restores Proliferation and Myeloid Differentiation of Neutropenia Patient Derived BM HSCs." Blood 136, Supplement 1 (2020): 23. http://dx.doi.org/10.1182/blood-2020-137215.

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Background: Mutations in ELANE are a cause of cyclic and severe congenital neutropenia (SCN), predominantly autosomal dominant disorders. ELANE encodes neutrophil elastase (NE), a tissue specific serine protease. Neutropenia occurs because mutant NE impairs survival and maturation of myeloid cells. More than 130 disease causing mutations in ELANE have been identified and cell permeable inhibitors of NE can correct the defect in cell survival and maturation in cellular models. (Makaryan et al. J Leukoc Biol. 2017;102:1143). CRISPR/Cas9 knock-out (KO) of ELANE in patients' hematopoietic stem cel

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7

Saha, Partha, and Arunima Biswas. "Non-Canonical WNT Pathway in Breast Cancer and Breast Cancer StemCell Signalling." Journal of PharmaSciTech 9, no. 1 (2020): 22–27. http://dx.doi.org/10.33981/jpst.2020.v09i01.004.

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8

Duerken, Matthias, Henriette Schneider, Jan Soerensen, and Peter Bader. "Successful Haploidentical Stemcell Transplantation In a Patient with Fanconi Anemia and AML." Blood 116, no. 21 (2010): 4586. http://dx.doi.org/10.1182/blood.v116.21.4586.4586.

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Abstract Abstract 4586 Allogeneic hematopoetic transplantation is the only curative treatment in patients with fanconi anemia indicated as soon transfusion dependency occurs and a matched family or unrelated donor is available. Overall survival for matched or nearly (5/6) matched unrelated donor transplantation improved since the introduction of fludarabine-based conditioning regimens from 30% to 53%. Transplantation after malignant transformation, in heavily pretransfused patients or from alternative donors is associated with a dismal outcome. We report the case of a 7 year old girl with fanc

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9

Vrehen, H. M. "1145 A nurse led out patient clinic for patients after stemcell transplantation." European Journal of Cancer Supplements 1, no. 5 (2003): S348. http://dx.doi.org/10.1016/s1359-6349(03)91171-2.

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10

Zheng, Hao, Sai Li, Ze-Yin Liang, et al. "M1 enrichment facilitates virus detection in patients with allogeneic hematopoietic stemcell transplantation." Medicine 104, no. 9 (2025): e41683. https://doi.org/10.1097/md.0000000000041683.

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Due to the severe consequences of viral infection in allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients, the routine use of polymerase chain reaction (PCR) screening of viruses is common in clinic, while the sensitivities of molecular methods are not always sufficient for blood samples. We aimed to increase the detection efficiency of viremia in allo-HSCT patients with M1 bead enrichment. Blood samples of allo-HSCT patients with fever were collected. Simultaneously with analyses of real-time PCR without enrichment, M1 bead enrichment followed by real-time PCR was applied t

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11

Walcher, Lia, Nadja Hilger, Anja K. Wege, et al. "Humanized mouse model: Hematopoietic stemcell transplantation and tracking using short tandem repeat technology." Immunity, Inflammation and Disease 8, no. 3 (2020): 363–70. http://dx.doi.org/10.1002/iid3.317.

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12

Massoud, Radwan, Evgeny Klyuchnikov, Ameya Shrinivas Kunte, et al. "Sequential Conditioning Does Not Improve Outcomes of Allogeneic Stemcell Transplantation in CMML Patients." Blood 142, Supplement 1 (2023): 2156. http://dx.doi.org/10.1182/blood-2023-188745.

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Background: Allogeneic stem cell transplantation (SCT) is potentially curative therapy for patients with CMML. Data on optimal allo-SCT conditioning in CMML Patients is scarce. Methods: This retrospective study from the Department of Stem Cell Transplantation at the University Medical Center Hamburg, Germany, compared allo-SCT outcomes in CMML patients across three conditioning regimes: Thiotepa-Busulfan (TB), Sequential FLAMSA-Busulfan Fludarabine (FLAMSA-FB), and Treosulfan-Fludarabine (Treo-Flu). TB consisted of Thiotapa ( 5mg/Kg; a total dose of 10mg/Kg) on day -6 and -5 and Busulfan (3.2m

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13

Ota, Akemi, Kazuaki Matsumura, Jun-Jae Lee, Shoichiro Sumi, and Soung-Hyu Hyon. "StemCell Keep™ is Effective for Cryopreservation of Human Embryonic Stem Cells by Vitrification." Cell Transplantation 26, no. 5 (2017): 773–87. http://dx.doi.org/10.3727/096368916x692654.

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Safe and stable cryopreservation is critical for research involving human embryonic stem cells (hESCs). Dimethyl sulfoxide (DMSO) is a popular cryoprotective agent; however, its cytotoxicity cannot be ignored. Thus, there is a need for an alternate cryoprotectant. We reported previously that a novel cryopreservation reagent, StemCell Keep™ (SCK), was effective for cryopreserving human induced pluripotent stem cells (hiPSCs) by vitrification. Because hESCs and hiPSCs are not identical, the current study examined the use of SCK on hESCs. hESCs cryopreserved with SCK were thawed and cultured on S

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14

Apewokin, Senu, Elizabeth Coleman, Carol Enderlin, et al. "438Genetic Variants Associated with the Development of Clostridium Difficile Infection during Autologous Stemcell Transplantation." Open Forum Infectious Diseases 1, suppl_1 (2014): S166—S167. http://dx.doi.org/10.1093/ofid/ofu052.304.

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15

Fliedner, M. "1147 Non-adherence in hematology and stemcell transplant patients — is it worth worrying about?" European Journal of Cancer Supplements 1, no. 5 (2003): S348. http://dx.doi.org/10.1016/s1359-6349(03)91173-6.

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16

Nooy, M. A., W. Fibbe, J. Ouwerkerk, D. van Benthem, and E. M. Noordijk. "1202 High-dose chemotherapy (HDC) with stemcell rescue for patients with metastatic Ewing's sarcoma." European Journal of Cancer 31 (November 1995): S251. http://dx.doi.org/10.1016/0959-8049(95)96448-m.

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17

Binh, Nguyen Thanh, and Pham Minh Anh. "Allele and haplotype frequencies in patients with Hematopoietic stemcell transplantation in National Children’s Hospital." Tạp chí Nghiên cứu Y học 166, no. 5E12 (2023): 155–62. http://dx.doi.org/10.52852/tcncyh.v166i5e12.1580.

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HLA (Human Leukocyte Antigen) gene is located on chromosome 6’s short arm, including several loci. HLA genotyping is necessary for transplantation, especially in hematopoietic stem cell transplantation. A cross-sectional study to determine the frequency of HLA-A, HLA-B, and HLA-DRB1 alleles of 122 patients admitted to the National Children’s Hospital for Hematopoietic stem cell transplantation from the year between 2010 and 2020. The patients’ HLA genotyping was performed by PCR-SSP method using Micro SSPTM Generic HLA Class I and II DNA Typing Tray (One Lambda). The results showed that the HL

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18

Ota, Akemi, Suong-Hyu Hyon, Shoichiro Sumi, and Kazuaki Matsumura. "Gene expression analysis of human induced pluripotent stem cells cryopreserved by vitrification using StemCell Keep." Biochemistry and Biophysics Reports 28 (December 2021): 101172. http://dx.doi.org/10.1016/j.bbrep.2021.101172.

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19

Versluys, Birgitta, M. Bierings, R. Schuurman, B. Ewijk, and J. J. Boelens. "Clinical Impact of Respiratory Viruses in Haematopoietic Stemcell Transplantation; a Firm Association with Bronchiolitis Obliterans." Blood 106, no. 11 (2005): 3230. http://dx.doi.org/10.1182/blood.v106.11.3230.3230.

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Abstract In lung transplants respiratory viruses (RV) are associated with bronchiolitis obliterans (BO). Also in HSCT patients RV may progress to pneumonia and may trigger immunological mediated effects on lungfunction.We prospectively studied the clinical impact of RV in pediatric HSCT patients. Between 1/2004 and 7/2005 46 patient underwent 51 allo-HSCTs in our center. In all patients with respiratory symptoms viral PCRs (adeno-, human metapneumo-, influenza-, corona-, parainfluenza-, rhino- and RS-virus) were done on a nasopharyngeal washing, in addition to standard diagnostics. The severit

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20

Suzliana, Rina Mutya, Tristiana Erawati, Cita Rosita Sigit Prakoeswa, Fedik Abdul Rantam, and Widji Soeratri. "Pengaruh Asam Hialuronat-Space Peptide terhadap Karakteristik, Stabilitas Fisik Gel Amniotic Membran-Stemcell Metabolite Product." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 7, no. 2 (2020): 66. http://dx.doi.org/10.20473/jfiki.v7i22020.66-73.

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Pendahuluan: Amniotic membran stem cell metabolite product (AMSC-MP) merupakan metabolit produk yang diperoleh dari Amniotic membrane yang diisolasi dan dikultur yang kemudian ditumbuhkan dalam medium terkondisi. AMSC-MP mengandung banyak growth factor dan sitokin yang sangat berguna sebagai antiaging. Growth factor dan sitokin yang pada umumnya berukuran besar lebih dari 20 KDa menyebabkan AMSC-MP membutuhkan formulasi khusus untuk penggunaannya secara topikal. Pada penelitian ini digunakan asam hialuronat dikombinasi dengan SPACE peptide yang memiliki fungsi sebagai enhancer makromolekul unt

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21

Naffaa, Moawiah M. "Neural circuit regulation of postnatal and adult subventricular zone neurogenesis: Mechanistic insights, functional models, and circuit-based neurological disorders." Archives of Stem Cell and Therapy 5, no. 1 (2024): 44–55. http://dx.doi.org/10.46439/stemcell.5.021.

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Neural circuits' role in regulating neurogenesis within the adult subventricular zone (SVZ) of the lateral ventricles (LV) has been extensively studied over the past two decades. The dynamic interplay between neurons, neurotransmitters, and LV neural stem cells (NSCs) highlights the critical influence of neural circuits on NSC renewal, proliferation, and differentiation. This article explores how neurotransmitters like dopamine, serotonin, GABA, acetylcholine, and glutamate regulate SVZ neurogenesis, revealing the cellular processes essential for NSC modulation and neuroblast generation. Recen

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22

Chatterjee, Aditi, Aerielle Matsangos, Olga S. Latinovic, Alonso Heredia, and Giovannino Silvestri. "Advancing towards HIV-1 remission: Insights and innovations in stem cell therapies." Archives of Stem Cell and Therapy 5, no. 1 (2024): 5–13. http://dx.doi.org/10.46439/stemcell.5.020.

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Human immunodeficiency virus type 1 (HIV-1) continues to pose a significant global health challenge despite advances in combined antiretroviral therapy (cART), which has transformed HIV-1 infection from a fatal disease to a manageable chronic condition. However, cART is not curative, and its long-term use is associated with challenges such as pill burden, drug toxicities, and the emergence of drug-resistant viral strains. The persistence of active viral reservoirs necessitates lifelong treatment, highlighting the need for alternative therapeutic strategies capable of achieving HIV-1 remission

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23

Addissouky, Tamer A. "From molecular mechanisms to precision medicine: Transformative approaches in cirrhosis management." Archives of Stem Cell and Therapy 5, no. 1 (2024): 22–31. https://doi.org/10.46439/stemcell.5.022.

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Background: Cirrhosis represents a major global health burden, driven by rising prevalence of risk factors like viral hepatitis, alcohol abuse, and obesity. Purpose: This paper reviews current understanding of cirrhosis pathogenesis, limitations of traditional therapies, and recent revolutionary innovations in disease management. Main Body: Chronic liver injury triggers inflammation and activation of hepatic stellate cells, key drivers of fibrosis. Resulting architectural distortions impair liver function. While conventional treatments like dietary modifications provide temporary relief, they

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24

Singh, Harsharan. "Bioengineering Providing Tailor-Made Products." Archives of Stem Cell and Therapy 5, no. 1 (2024): 32–43. https://doi.org/10.46439/stemcell.5.023.

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Bioengineering is a new discipline of science that apply engineering principles and techniques on the biological process for development of valuable bioactive molecule, designing metabolites and changing cells or cellular metabolites to combat the current as well as future challenges and problem of mankind. This is one of the most challenging fields testing the researcher’s intelligence, dedication, skill and creativity and courage needed to contradict convention and cut new pathways through unexplored scientific terrain. Bioengineering has the potential to provide economical processes and met

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25

Wilson, George D., and Di Yan. "The tumor dose sensitivity matrix and stem cells in head and neck cancer." Archives of Stem Cell and Therapy 4, no. 1 (2023): 1–4. http://dx.doi.org/10.46439/stemcell.4.018.

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26

Mahmood, Anjum, Naman Somani, Divyang Patel, Rangnath Mishra, and Anand Srivastsva. "Stem cell secretome-mediated alleviation of scalp psoriasis: A case report." Archives of Stem Cell and Therapy 5, no. 1 (2024): 1–4. http://dx.doi.org/10.46439/stemcell.5.019.

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Scalp psoriasis, a skin condition characterized by red, thickened (erythematous), well-demarcated patches or plaques with overlying silvery-white scales, affecting part or all of the scalp, is an autoimmune disease accompanied by itchy skin. The disease is associated with faulty functioning of adaptive and innate components of immune systems. The key proinflammatory cytokines mediating immunopathology of psoriasis are IL-17 and IL-23 which promote proliferation of Th 17 cells which in turn induce proliferation of keratinocytes leading to the disease. Standard management of psoriasis primarily

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27

Rohit, Raghavan, P.A Shajahan, and Praseera. "Stem Cell Based Tooth Regeneration- An Alternative Approach to Implant Dentistry?" International Journal of Innovative Science and Research Technology 8, no. 3 (2023): 696–701. https://doi.org/10.5281/zenodo.7765298.

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- Implant dentistry is the branch of dentistry that deals with replacing lost teeth and the structures that support them with artificial prostheses that are attached (osteointegrated) to the jaw bone. The regeneration of hard dental tissues has become a reality and a top goal in contemporary dentistry with the development of the current idea of tissue engineering approach and the discovery of the potential of stem cells in dentistry. The current review summarises recent developments in stemcell-based regeneration techniques for hard dental tissues and assesses the viability of using growth fac

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28

de Greef, Georgine E., Annemiek Broyl, and Jaco Kraan. "The Mobilisation of Peripheral Blood Stemcells in Patients with High Risk or Relapsed Non-Hodgkin Lymphoma Does Not Lead to the Presence of Detectable Tumour Cells in the Stem Cell Harvest." Blood 104, no. 11 (2004): 2873. http://dx.doi.org/10.1182/blood.v104.11.2873.2873.

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Abstract Consolidation treatment with high dose chemotherapy in combination with an autologous peripheral blood stem celll transplant. is widely used in patients with high risk non-Hodgkin lymphoma (NHL). Also this treatment has its place in patients with relapsed intermediate lymphoma. Earlier studies in patients with breast cancer or multiple myeloma showed evidence for (minimal) tumour contamination in the graft that might lead to the occurence of relapse. For patients with NHL this is less clear. For the present analysis 60 patients (pts) were included: 18 pts with primary high risk NHL, 6

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Douek, Daniel C., Robert A. Vescio, Michael R. Betts, et al. "Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution." Lancet 355, no. 9218 (2000): 1875–81. http://dx.doi.org/10.1016/s0140-6736(00)02293-5.

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Su, Z., J. Wu, N. Kirby, Z. Li, and I. Barani. "SU-E-T-568: Hippocampus and Neural Stemcell Sparing Using Proton Therapy in Whole Brain Irradiation." Medical Physics 39, no. 6Part19 (2012): 3836. http://dx.doi.org/10.1118/1.4735657.

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31

Massoud, Radwan, Ameya Shrinivas Kunte, Evgeny Klyuchnikov, et al. "The Impact of Anti-T-Lymphocyte-Globulin Dosing on Gvhd in Matched Sibling Allogeneic Stemcell Transplantation." Blood 142, Supplement 1 (2023): 7014. http://dx.doi.org/10.1182/blood-2023-188880.

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Introduction: Due to the graft versus tumor effect allogeneic stem cell transplantation (allo-SCT) is a curative strategy for hematological malignancies. However, its benefits are offset by non-related mortality (NRM) primarily from graft-versus-host-disease (GVHD). In vivo T-cell depletion (TCD) with Anti-T-Lymphocyte globulin (ATLG) can reduce GVHD. Although lower ATLG doses may compromise the immunosuppression effects, higher ATLG doses may offset its benefit by decreasing antiviral and graft-versus-malignancy effect by depletion of donor effector T cells. Even though the use of ATLG in all

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32

Jurczak, Wojciech, Marta Szostek, Zbigniew Rudzki, et al. "Impaired Clonogenic Capacity Contributes to Bone Marrow Hypoplasia and Late Hematological Recovery after Zevalin in the Low-Grade NHL Patients." Blood 104, no. 11 (2004): 4610. http://dx.doi.org/10.1182/blood.v104.11.4610.4610.

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Abstract Chemoimmunotherapy with Zevalin (anty CD20,90Y) is a new therapeutic approach in the resistant or relapsed low grade malignant lymphoma patients. The most important side effect observed in the up to date studies is related to transient peripheral blood cytopenias. In an attempt to evaluate the involved pathogenetic mechanisms of the above findings, the blood and bone marrow samples from 8 low grade NHL patients were prospectively tested for the peripheral blood count, the clonogenic capacity and the histopathology abnormalities (trephine biopsies) before and every 14 days after Zevali

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Bonfichi, Maurizio, Ercole Brusamolino, Carmela Marseglia, Chiara Rusconi, and Mario Lazzarino. "Evaluation of Progenitor Cells (CFU-GM, CFU-GEMM, BFU-E, CD34+ Cells) and White Blood Cells in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma Treated with Rituximab-CHOP-14 and Supported with Pegfilgrastim." Blood 106, no. 11 (2005): 4245. http://dx.doi.org/10.1182/blood.v106.11.4245.4245.

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Abstract Purpose: To investigate the behavior of CFU-GM, CFU-GEMM, BFU-E, CD34+ cells and white blood cells before and during six courses of dose-dense immune-chemotherapy (R-CHOP-14) supported by pegfilgrastim in eight patients affected with newly diagnosed diffuse large B cell lymphoma (3 men, 5 women, aged 18–51). Patients and Methods: The standard-dose CHOP chemotherapy was delivered every 14 days, preceded on day 1 by rituximab (375 mg/m2) and followed on day 3 by pegfilgrastim (6 mg per cycle). In each course of therapy, the evaluation was performed before treatment (day 1) and on days +

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Leitner, G. C., A. Bartuschka, and A. Schulenburg. "Measurement of Aldehyde Dehydrogenase Activity in Allogeneic or Autologous Peripheral Stemcell Grafts May Substitute Time Consuming Cells Cultures." Biology of Blood and Marrow Transplantation 17, no. 2 (2011): S206. http://dx.doi.org/10.1016/j.bbmt.2010.12.165.

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35

Shamim, Zaiba, Stephanie Thiant, Sylvie Faucher, et al. "Plasma Levels of Soluble Interleukin-7 Receptor Alpha (sIL-7Ra) and IL-7Ra Polymorphism After Allogeneic Stemcell Transplantation,." Blood 118, no. 21 (2011): 4012. http://dx.doi.org/10.1182/blood.v118.21.4012.4012.

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Abstract Abstract 4012 Background: Interleukin-7 (IL-7) is a cytokine essential for T cell development in the thymus and maintenance of peripheral T cells. IL-7 binds to cellular IL-7 receptors (IL-7Ra-common g chain heterodimer), in competition with a soluble form of the receptor, shed by the cells (sIL-7Ra). We have identified single nucleotide polymorphisms in the exons of the gene encoding IL-7Ra (+510T/C rs1494558, +1237 G/C rs1494555, 2087 C/T rs6897932), and previous results by us and by others indicate that IL-7R SNPs are associated with aGvHD and mortality after SCT. Moreover, the bio

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Hussain, Ali, Moazzam Shahzad, Sakina Abbas, et al. "Outcomes with Allogeneic Hematopoietic Stemcell Transplantation in NPM1-Mutated Acute Myeloid Leukemia: A Systematic Review And Meta-Analysis." Transplantation and Cellular Therapy 29, no. 2 (2023): S125—S126. http://dx.doi.org/10.1016/s2666-6367(23)00224-5.

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Figueroa, Byron, Martin Ferrando, Sebastian Galeano, et al. "Comparison of Cryopreserved Versus Non-Cryopreserved Strategies for Autologous Stemcell Transplantation in Multiple Myeloma in Two Centers in Uruguay." Blood 144, Supplement 1 (2024): 2093. https://doi.org/10.1182/blood-2024-205289.

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Introduction: Autologous hematopoietic stem cell transplantation (ASCT) is a standard treatment for many hematologic malignancies. Multiple Myeloma (MM) is the main indication for ASCT in adults in Latin America and worldwide. The classic methodology for performing ASCT includes cryopreservation of the stem cell product during the period from collection to infusion. Recent studies have demonstrated the feasibility of performing ASCT in MM by maintaining the stem cell product at 4°c while the patient receives the conditioning regimen. Objective: The primary objective was to compare time to neut

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Janicsák, Henrietta, Tamás Masszi, Péter Reményi, Gabor S. Ungvari, and Gábor Gazdag. "Impact of the type of hematopoietic stem-cell transplant on quality of life and psychopathology." Ideggyógyászati szemle 76, no. 1-2 (2023): 25–35. http://dx.doi.org/10.18071/isz.76.0025.

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Background and purpose – Despite the decrease in transplant-related mortality, patients who receive hematopoietic stemcell transplants often suffer from short-and long-term morbidities, poorer quality of life, and psychosocial functioning deficits. Several studies have compared the quality of life and affective symptoms of patients after undergoing autologous and allogeneic hematopoietic stem-cell transplants. Some studies have reported similar or greater quality of life impairments in allogeneic hematopoietic stemcell recipients, but the findings have been inconsistent. Our purpose was to exa

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Latham, Stephen R. "Between Public Opinion and Public Policy: Human Embryonic Stem-Cell Research and Path-Dependency." Journal of Law, Medicine & Ethics 37, no. 4 (2009): 800–806. http://dx.doi.org/10.1111/j.1748-720x.2009.00451.x.

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My aim in this paper is simply to show that, in bioethics no less than in other areas of health care, policy in democracies is shaped not only by principles and values, but also — and to some extent independently — by the shape and history of particular political institutions and past policies. “Path dependency,” or what one scholar has called the “accidental logics” of already-existing institutions, condition and guide national policy choices. These institutional and historical pressures can even create substantial policy divergences between quite likeminded nations. I shall illustrate the po

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40

Kröger, Nicolaus. "Prevention of Chronic Graft-versus-host Disease and the Unique Role of Anti-human T-lymphocyte Immune Globulin." European Oncology & Haematology 12, no. 02 (2016): 93. http://dx.doi.org/10.17925/eoh.2016.12.02.93.

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Chronic graft-versus-host disease (GVHD) is a major cause of late morbidity and mortality post-allogeneic haematopoietic stemcell transplantation. Compared with acute GVHD, for which progress in preventative measures have been made, chronic GVHD describes a more diverse syndrome, and may adversely affect almost all organs in the body. A new prospective, multicentre, open-label, randomised phase III study (n=168) showed that the use of anti-human T-lymphocyte immune globulin (ATLG) in a myeloablative conditioning regimen for patients with acute leukaemia led to a significantly lower rate of chr

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Wermke, M., J. Eckoldt, K. S. Götze, et al. "Labile Plasma Iron Predicts for Survival in Patients Undergoing Allogeneic Stemcell-Transplantation – Results from the Prospective Multicenter German-Austrian Allive Trial." Leukemia Research 55 (April 2017): S5—S6. http://dx.doi.org/10.1016/s0145-2126(17)30124-8.

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42

Inoue, Kana, Akiko Sumitomo, Natsumi Hasegawa, et al. "Involvement of Transcriptional Mediator Subunit TRAP220/MED1 in Action of Niche Cells to Support Hematopoietic Stem/Progenitor Cells." Blood 112, no. 11 (2008): 3581. http://dx.doi.org/10.1182/blood.v112.11.3581.3581.

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Abstract The mammalian TRAP/Mediator complex is a master transcriptional regulatory complex that integrates signals of diverse activators and recruits RNA polymerase II and other general factors to activate transcription. The TRAP220/MED1 subunit was originally identified as a ligand-dependent coactivator specific for nuclear receptors. We have previously shown through biochemical and mouse genetic studies that MED1 is essential for embryogenesis, cell growth/differentiation and homeostasis, and that it stimulates nuclear receptor-mediated myelomonopoiesis. MED1 also integrates other activator

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Ampudia, Jeanette, Dalena Chu, Jana Badrani, Taylor Doherty, Stephen Connelly, and Cherie Tracy Ng. "Impact of Itolizumab on the Expression of CD6 and the Function of Effector T Cells." Blood 136, Supplement 1 (2020): 25–26. http://dx.doi.org/10.1182/blood-2020-141638.

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Introduction: CD6 is a T-cell costimulatory receptor that has been implicated in the pathogenesis of multiple autoimmune and inflammatory (AI) diseases. In GVHD, CD6 is expressed on reconstituting T cells soon after transplant (Rambaldi et al., 2019), including Th1 and Th17 cells which are both implicated in the induction and pathogenesis of acute GVHD (aGVHD). CD6 is highly expressed on these cells and promotes immune synapse formation, T-cell activation, and T-cell migration via interaction with its ligand activated leukocyte cell adhesion molecule (ALCAM). Furthermore, studies have demonstr

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Yang, Tingting, Xueping Luo, Qing Yang, et al. "The Effect of Continuous Screening of Carbapenem-Resistant Enterobacteriaceae on Theprevention and Control of Bloodstream Infections in Patients with Hematopoietic Stemcell Transplantation." Blood 134, Supplement_1 (2019): 5606. http://dx.doi.org/10.1182/blood-2019-127599.

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Carbapenem-resistant Enterobacteriaceae (CRE) bloodstream infections (BSIs) have become emerging cause of death in patients with hematopoietic stem cell transplantation (HSCT). Patients underwent HSCT from September 2017 to June 2018, and from July 2018 to February 2019, were assigned as single screening group and continuous screening group; patients transplanted from January 2016 to August 2017 were assigned as control group. Continuous screening significantly improved the CRE gut detection rate compared with single screening (10% vs 1.5%, p=0.001). The CRE infection rate in the pre-intervent

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Simbulan-Rosenthal, Dougherty, Vakili, et al. "CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis." Cancers 11, no. 10 (2019): 1490. http://dx.doi.org/10.3390/cancers11101490.

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CD133, known as prominin1, is a penta-span transmembrane glycoprotein presumably acancer stem cell marker for carcinomas, glioblastomas, and melanomas. We showed that CD133(+)‘melanoma-initiating cells’ are associated with chemoresistance, contributing to poor patientoutcome. The current study investigates the role(s) of CD133 in invasion and metastasis. Magneticactivatedcell sorting of a melanoma cell line (BAKP) followed by transwell invasion assays revealedthat CD133(+) cells are significantly more invasive than CD133(−) cells. Conditional reprogrammingof BAKP CD133(+) cells maintained stab

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Li, Ming, and Susumu Ikehara. "Prospects for Cell Based Therapy for Type 1 Diabetes." Archives of Stem Cell Research 1, no. 1 (2014): 1–2. http://dx.doi.org/10.47739/2578-3580.stemcell.1001.

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Palumbo, Paola, Francesca Lombardi, Giuseppe Siragusa, et al. "Involvement of NOS2 Activity on Human Glioma Cell Growth, Clonogenic Potential, and Neurosphere Generation." International Journal of Molecular Sciences 19, no. 9 (2018): 2801. http://dx.doi.org/10.3390/ijms19092801.

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Aberrant nitric oxide synthase 2 (NOS2) expression has been suggested as an interesting therapeutic target that is being implicated as a component of the molecular profile of several human malignant tumors, including glioblastoma, which is the most aggressive brain tumor with limited therapeutic options and poor prognosis. The aim of the present work was to evaluate the effect of 1400W, a specific NOS2 inhibitor, on human glioma cells in terms of clonogenic potential, proliferation, migration rate, and neurosphere generation ability. NOS2 expression was determined by Western blotting. Nitric o

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Kokaji, Andy, Neil MacDonald, Maureen Fairhurst, and Terry Thomas. "A rapid and efficient method for the isolation of distinct human regulatory T cell populations using combinations of antibody mediated buoyant density centrifugation and/or column-free immunomagnetic cell separation (143.41)." Journal of Immunology 184, no. 1_Supplement (2010): 143.41. http://dx.doi.org/10.4049/jimmunol.184.supp.143.41.

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Abstract Regulatory T cells (Tregs) are a specialized subset of T cells that play a key role in immune regulation. Harnessing the suppressive function of Tregs is a major area of interest as they hold great potential for the treatment of autoimmune disorders. The first step towards quality Treg research is the isolation of highly purified, functional Tregs. With unique cell isolation platforms, STEMCELL has developed a full range of products for the rapid and efficient isolation of highly functional Tregs from virtually any peripheral blood sample. RosetteSep is an antibody mediated buoyant de

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Dean, Melinda M., Thu V. Tran, Yu Ji, et al. "Development of a Semi-automated Monocyte Monolayer Assay (MMA) to Determine the Clinical Significance of Red Cell Alloantibodies." Journal of Immunology 204, no. 1_Supplement (2020): 86.55. http://dx.doi.org/10.4049/jimmunol.204.supp.86.55.

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Abstract BACKGROUND One risk of allogeneic blood transfusion is the development of alloantibodies against red blood cell (RBC) antigens not found on the recipient’s RBC. The monocyte monolayer assay (MMA) is an in vitro model which has been used to determine the clinical significance of alloantibodies and predict post-transfusion RBC survival. We aimed to develop a semi-automated procedure to reduce assay time and facilitate improved patient management. METHODS PBMCs isolated using Sepmate tubes (STEMCELL Technologies) were added to Lab-Tek 8-well chamber slides (37°C, 1 hr, CO2). Antigen matc

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Kim, Ock-Joo. "The Role of Institutional Review Boards and Stem Cell Research." Korean Journal of Medical Ethics 6, no. 1 (2003): 21–33. http://dx.doi.org/10.35301/ksme.2003.6.1.21.

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This paper examines the role of the institutional review (IRB) board with special reference to stem cell research. The main question raised in this paper is whether ethics review by local IRBs is sufficient for human embryonic stem cell research. In spite of growing dissatisfaction with current IRB operation, most countries recognize the importance of function of IRBs for guarding social and ethical values in human embryonic research. While a few countries completely banned all kinds of research which derives stem cell from human embryo, other countries like Japan and UK allow human embryonic

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